Visualizing the assembly pathway of nucleolar pre-60S ribosomes
Summary Eukaryotic 60S ribosomal subunits are comprised of three rRNAs and ∼50 ribosomal proteins. The initial steps of their formation take place in the nucleolus, but, owing to a lack of structural information, this process is poorly understood. Using cryo-EM, we solved structures of early 60S bio...
Ausführliche Beschreibung
Autor*in: |
Kater, Lukas - 1989- [verfasserIn] Thoms, Matthias [verfasserIn] Ismail, Sherif - 1991- [verfasserIn] Ahmed, Yasar Luqman [verfasserIn] Bange, Gert [verfasserIn] Sinning, Irmgard - 1960- [verfasserIn] Hurt, Ed - 1955- [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
December 14, 2017 |
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Schlagwörter: |
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Anmerkung: |
Gesehen am 16.07.2018 |
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Umfang: |
12 |
Übergeordnetes Werk: |
Enthalten in: Cell - [Cambridge, Mass.] : Cell Press, 1974, 171(2017), 7, Seite 1599-1610 |
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Übergeordnetes Werk: |
volume:171 ; year:2017 ; number:7 ; pages:1599-1610 ; extent:12 |
Links: |
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DOI / URN: |
10.1016/j.cell.2017.11.039 |
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Katalog-ID: |
1577627709 |
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520 | |a Summary Eukaryotic 60S ribosomal subunits are comprised of three rRNAs and ∼50 ribosomal proteins. The initial steps of their formation take place in the nucleolus, but, owing to a lack of structural information, this process is poorly understood. Using cryo-EM, we solved structures of early 60S biogenesis intermediates at 3.3 Å to 4.5 Å resolution, thereby providing insights into their sequential folding and assembly pathway. Besides revealing distinct immature rRNA conformations, we map 25 assembly factors in six different assembly states. Notably, the Nsa1-Rrp1-Rpf1-Mak16 module stabilizes the solvent side of the 60S subunit, and the Erb1-Ytm1-Nop7 complex organizes and connects through Erb1’s meandering N-terminal extension, eight assembly factors, three ribosomal proteins, and three 25S rRNA domains. Our structural snapshots reveal the order of integration and compaction of the six major 60S domains within early nucleolar 60S particles developing stepwise from the solvent side around the exit tunnel to the central protuberance. | ||
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December 14, 2017 |
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2017 |
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10.1016/j.cell.2017.11.039 doi (DE-627)1577627709 (DE-576)507627709 (DE-599)BSZ507627709 (OCoLC)1341013772 DE-627 ger DE-627 rda eng Kater, Lukas 1989- verfasserin (DE-588)1162857374 (DE-627)1026952204 (DE-576)507626559 aut Visualizing the assembly pathway of nucleolar pre-60S ribosomes Lukas Kater, Matthias Thoms, Clara Barrio-Garcia, Jingdong Cheng, Sherif Ismail, Yasar Luqman Ahmed, Gert Bange, Dieter Kressler, Otto Berninghausen, Irmgard Sinning, Ed Hurt, Roland Beckmann December 14, 2017 12 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 16.07.2018 Summary Eukaryotic 60S ribosomal subunits are comprised of three rRNAs and ∼50 ribosomal proteins. The initial steps of their formation take place in the nucleolus, but, owing to a lack of structural information, this process is poorly understood. Using cryo-EM, we solved structures of early 60S biogenesis intermediates at 3.3 Å to 4.5 Å resolution, thereby providing insights into their sequential folding and assembly pathway. Besides revealing distinct immature rRNA conformations, we map 25 assembly factors in six different assembly states. Notably, the Nsa1-Rrp1-Rpf1-Mak16 module stabilizes the solvent side of the 60S subunit, and the Erb1-Ytm1-Nop7 complex organizes and connects through Erb1’s meandering N-terminal extension, eight assembly factors, three ribosomal proteins, and three 25S rRNA domains. Our structural snapshots reveal the order of integration and compaction of the six major 60S domains within early nucleolar 60S particles developing stepwise from the solvent side around the exit tunnel to the central protuberance. cryo-electron microscopy assembly Erb1 large subunit assembly Nsa1 nucleolus pre-60S ribosome ribosome biogenesis Thoms, Matthias verfasserin (DE-588)1044453427 (DE-627)772066868 (DE-576)397675542 aut Ismail, Sherif 1991- verfasserin (DE-588)1162857668 (DE-627)1026952875 (DE-576)507626893 aut Ahmed, Yasar Luqman verfasserin (DE-588)1155841832 (DE-627)101832612X (DE-576)501896260 aut Bange, Gert verfasserin (DE-588)135801354 (DE-627)57166489X (DE-576)300653719 aut Sinning, Irmgard 1960- verfasserin (DE-588)1027598617 (DE-627)72945133X (DE-576)166290580 aut Hurt, Ed 1955- verfasserin (DE-588)11021952X (DE-627)729291863 (DE-576)373308574 aut Enthalten in Cell [Cambridge, Mass.] : Cell Press, 1974 171(2017), 7, Seite 1599-1610 Online-Ressource (DE-627)320416127 (DE-600)2001951-8 (DE-576)090881370 1097-4172 nnns volume:171 year:2017 number:7 pages:1599-1610 extent:12 http://dx.doi.org/10.1016/j.cell.2017.11.039 Verlag Resolving-System kostenfrei Volltext http://www.sciencedirect.com/science/article/pii/S0092867417314290 Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 171 2017 7 1599-1610 12 2013 01 DE-16-250 301760344X 00 --%%-- --%%-- --%%-- --%%-- l01 16-07-18 2403 01 DE-LFER 3020630282 00 --%%-- --%%-- n --%%-- l01 13-08-18 2403 01 DE-LFER http://dx.doi.org/10.1016/j.cell.2017.11.039 2013 01 DE-16-250 00 s hd2017 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_12 2013 01 DE-16-250 03 s s_12 2013 01 DE-16-250 04 p (DE-627)1467675695 Thoms, Matthias 2013 01 DE-16-250 04 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_2 2013 01 DE-16-250 05 p (DE-627)1577627490 Ismail, Sherif 2013 01 DE-16-250 05 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_5 2013 01 DE-16-250 06 p (DE-627)1571895914 Ahmed, Yasar Luqman 2013 01 DE-16-250 06 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_6 2013 01 DE-16-250 07 p (DE-627)1443439061 Bange, Gert 2013 01 DE-16-250 07 k (DE-627)1416822720 Extern 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_7 2013 01 DE-16-250 08 p (DE-627)1443444928 Sinning, Irmgard 2013 01 DE-16-250 08 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 08 k (DE-627)1416737693 Exzellenzcluster Zelluläre Netzwerke (EXCCN) 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_10 2013 01 DE-16-250 09 p (DE-627)1443445231 Hurt, Ed 2013 01 DE-16-250 09 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 09 k (DE-627)1416737693 Exzellenzcluster Zelluläre Netzwerke (EXCCN) 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_11 |
spelling |
10.1016/j.cell.2017.11.039 doi (DE-627)1577627709 (DE-576)507627709 (DE-599)BSZ507627709 (OCoLC)1341013772 DE-627 ger DE-627 rda eng Kater, Lukas 1989- verfasserin (DE-588)1162857374 (DE-627)1026952204 (DE-576)507626559 aut Visualizing the assembly pathway of nucleolar pre-60S ribosomes Lukas Kater, Matthias Thoms, Clara Barrio-Garcia, Jingdong Cheng, Sherif Ismail, Yasar Luqman Ahmed, Gert Bange, Dieter Kressler, Otto Berninghausen, Irmgard Sinning, Ed Hurt, Roland Beckmann December 14, 2017 12 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 16.07.2018 Summary Eukaryotic 60S ribosomal subunits are comprised of three rRNAs and ∼50 ribosomal proteins. The initial steps of their formation take place in the nucleolus, but, owing to a lack of structural information, this process is poorly understood. Using cryo-EM, we solved structures of early 60S biogenesis intermediates at 3.3 Å to 4.5 Å resolution, thereby providing insights into their sequential folding and assembly pathway. Besides revealing distinct immature rRNA conformations, we map 25 assembly factors in six different assembly states. Notably, the Nsa1-Rrp1-Rpf1-Mak16 module stabilizes the solvent side of the 60S subunit, and the Erb1-Ytm1-Nop7 complex organizes and connects through Erb1’s meandering N-terminal extension, eight assembly factors, three ribosomal proteins, and three 25S rRNA domains. Our structural snapshots reveal the order of integration and compaction of the six major 60S domains within early nucleolar 60S particles developing stepwise from the solvent side around the exit tunnel to the central protuberance. cryo-electron microscopy assembly Erb1 large subunit assembly Nsa1 nucleolus pre-60S ribosome ribosome biogenesis Thoms, Matthias verfasserin (DE-588)1044453427 (DE-627)772066868 (DE-576)397675542 aut Ismail, Sherif 1991- verfasserin (DE-588)1162857668 (DE-627)1026952875 (DE-576)507626893 aut Ahmed, Yasar Luqman verfasserin (DE-588)1155841832 (DE-627)101832612X (DE-576)501896260 aut Bange, Gert verfasserin (DE-588)135801354 (DE-627)57166489X (DE-576)300653719 aut Sinning, Irmgard 1960- verfasserin (DE-588)1027598617 (DE-627)72945133X (DE-576)166290580 aut Hurt, Ed 1955- verfasserin (DE-588)11021952X (DE-627)729291863 (DE-576)373308574 aut Enthalten in Cell [Cambridge, Mass.] : Cell Press, 1974 171(2017), 7, Seite 1599-1610 Online-Ressource (DE-627)320416127 (DE-600)2001951-8 (DE-576)090881370 1097-4172 nnns volume:171 year:2017 number:7 pages:1599-1610 extent:12 http://dx.doi.org/10.1016/j.cell.2017.11.039 Verlag Resolving-System kostenfrei Volltext http://www.sciencedirect.com/science/article/pii/S0092867417314290 Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 171 2017 7 1599-1610 12 2013 01 DE-16-250 301760344X 00 --%%-- --%%-- --%%-- --%%-- l01 16-07-18 2403 01 DE-LFER 3020630282 00 --%%-- --%%-- n --%%-- l01 13-08-18 2403 01 DE-LFER http://dx.doi.org/10.1016/j.cell.2017.11.039 2013 01 DE-16-250 00 s hd2017 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_12 2013 01 DE-16-250 03 s s_12 2013 01 DE-16-250 04 p (DE-627)1467675695 Thoms, Matthias 2013 01 DE-16-250 04 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_2 2013 01 DE-16-250 05 p (DE-627)1577627490 Ismail, Sherif 2013 01 DE-16-250 05 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_5 2013 01 DE-16-250 06 p (DE-627)1571895914 Ahmed, Yasar Luqman 2013 01 DE-16-250 06 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_6 2013 01 DE-16-250 07 p (DE-627)1443439061 Bange, Gert 2013 01 DE-16-250 07 k (DE-627)1416822720 Extern 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_7 2013 01 DE-16-250 08 p (DE-627)1443444928 Sinning, Irmgard 2013 01 DE-16-250 08 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 08 k (DE-627)1416737693 Exzellenzcluster Zelluläre Netzwerke (EXCCN) 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_10 2013 01 DE-16-250 09 p (DE-627)1443445231 Hurt, Ed 2013 01 DE-16-250 09 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 09 k (DE-627)1416737693 Exzellenzcluster Zelluläre Netzwerke (EXCCN) 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_11 |
allfields_unstemmed |
10.1016/j.cell.2017.11.039 doi (DE-627)1577627709 (DE-576)507627709 (DE-599)BSZ507627709 (OCoLC)1341013772 DE-627 ger DE-627 rda eng Kater, Lukas 1989- verfasserin (DE-588)1162857374 (DE-627)1026952204 (DE-576)507626559 aut Visualizing the assembly pathway of nucleolar pre-60S ribosomes Lukas Kater, Matthias Thoms, Clara Barrio-Garcia, Jingdong Cheng, Sherif Ismail, Yasar Luqman Ahmed, Gert Bange, Dieter Kressler, Otto Berninghausen, Irmgard Sinning, Ed Hurt, Roland Beckmann December 14, 2017 12 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 16.07.2018 Summary Eukaryotic 60S ribosomal subunits are comprised of three rRNAs and ∼50 ribosomal proteins. The initial steps of their formation take place in the nucleolus, but, owing to a lack of structural information, this process is poorly understood. Using cryo-EM, we solved structures of early 60S biogenesis intermediates at 3.3 Å to 4.5 Å resolution, thereby providing insights into their sequential folding and assembly pathway. Besides revealing distinct immature rRNA conformations, we map 25 assembly factors in six different assembly states. Notably, the Nsa1-Rrp1-Rpf1-Mak16 module stabilizes the solvent side of the 60S subunit, and the Erb1-Ytm1-Nop7 complex organizes and connects through Erb1’s meandering N-terminal extension, eight assembly factors, three ribosomal proteins, and three 25S rRNA domains. Our structural snapshots reveal the order of integration and compaction of the six major 60S domains within early nucleolar 60S particles developing stepwise from the solvent side around the exit tunnel to the central protuberance. cryo-electron microscopy assembly Erb1 large subunit assembly Nsa1 nucleolus pre-60S ribosome ribosome biogenesis Thoms, Matthias verfasserin (DE-588)1044453427 (DE-627)772066868 (DE-576)397675542 aut Ismail, Sherif 1991- verfasserin (DE-588)1162857668 (DE-627)1026952875 (DE-576)507626893 aut Ahmed, Yasar Luqman verfasserin (DE-588)1155841832 (DE-627)101832612X (DE-576)501896260 aut Bange, Gert verfasserin (DE-588)135801354 (DE-627)57166489X (DE-576)300653719 aut Sinning, Irmgard 1960- verfasserin (DE-588)1027598617 (DE-627)72945133X (DE-576)166290580 aut Hurt, Ed 1955- verfasserin (DE-588)11021952X (DE-627)729291863 (DE-576)373308574 aut Enthalten in Cell [Cambridge, Mass.] : Cell Press, 1974 171(2017), 7, Seite 1599-1610 Online-Ressource (DE-627)320416127 (DE-600)2001951-8 (DE-576)090881370 1097-4172 nnns volume:171 year:2017 number:7 pages:1599-1610 extent:12 http://dx.doi.org/10.1016/j.cell.2017.11.039 Verlag Resolving-System kostenfrei Volltext http://www.sciencedirect.com/science/article/pii/S0092867417314290 Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 171 2017 7 1599-1610 12 2013 01 DE-16-250 301760344X 00 --%%-- --%%-- --%%-- --%%-- l01 16-07-18 2403 01 DE-LFER 3020630282 00 --%%-- --%%-- n --%%-- l01 13-08-18 2403 01 DE-LFER http://dx.doi.org/10.1016/j.cell.2017.11.039 2013 01 DE-16-250 00 s hd2017 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_12 2013 01 DE-16-250 03 s s_12 2013 01 DE-16-250 04 p (DE-627)1467675695 Thoms, Matthias 2013 01 DE-16-250 04 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_2 2013 01 DE-16-250 05 p (DE-627)1577627490 Ismail, Sherif 2013 01 DE-16-250 05 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_5 2013 01 DE-16-250 06 p (DE-627)1571895914 Ahmed, Yasar Luqman 2013 01 DE-16-250 06 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_6 2013 01 DE-16-250 07 p (DE-627)1443439061 Bange, Gert 2013 01 DE-16-250 07 k (DE-627)1416822720 Extern 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_7 2013 01 DE-16-250 08 p (DE-627)1443444928 Sinning, Irmgard 2013 01 DE-16-250 08 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 08 k (DE-627)1416737693 Exzellenzcluster Zelluläre Netzwerke (EXCCN) 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_10 2013 01 DE-16-250 09 p (DE-627)1443445231 Hurt, Ed 2013 01 DE-16-250 09 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 09 k (DE-627)1416737693 Exzellenzcluster Zelluläre Netzwerke (EXCCN) 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_11 |
allfieldsGer |
10.1016/j.cell.2017.11.039 doi (DE-627)1577627709 (DE-576)507627709 (DE-599)BSZ507627709 (OCoLC)1341013772 DE-627 ger DE-627 rda eng Kater, Lukas 1989- verfasserin (DE-588)1162857374 (DE-627)1026952204 (DE-576)507626559 aut Visualizing the assembly pathway of nucleolar pre-60S ribosomes Lukas Kater, Matthias Thoms, Clara Barrio-Garcia, Jingdong Cheng, Sherif Ismail, Yasar Luqman Ahmed, Gert Bange, Dieter Kressler, Otto Berninghausen, Irmgard Sinning, Ed Hurt, Roland Beckmann December 14, 2017 12 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 16.07.2018 Summary Eukaryotic 60S ribosomal subunits are comprised of three rRNAs and ∼50 ribosomal proteins. The initial steps of their formation take place in the nucleolus, but, owing to a lack of structural information, this process is poorly understood. Using cryo-EM, we solved structures of early 60S biogenesis intermediates at 3.3 Å to 4.5 Å resolution, thereby providing insights into their sequential folding and assembly pathway. Besides revealing distinct immature rRNA conformations, we map 25 assembly factors in six different assembly states. Notably, the Nsa1-Rrp1-Rpf1-Mak16 module stabilizes the solvent side of the 60S subunit, and the Erb1-Ytm1-Nop7 complex organizes and connects through Erb1’s meandering N-terminal extension, eight assembly factors, three ribosomal proteins, and three 25S rRNA domains. Our structural snapshots reveal the order of integration and compaction of the six major 60S domains within early nucleolar 60S particles developing stepwise from the solvent side around the exit tunnel to the central protuberance. cryo-electron microscopy assembly Erb1 large subunit assembly Nsa1 nucleolus pre-60S ribosome ribosome biogenesis Thoms, Matthias verfasserin (DE-588)1044453427 (DE-627)772066868 (DE-576)397675542 aut Ismail, Sherif 1991- verfasserin (DE-588)1162857668 (DE-627)1026952875 (DE-576)507626893 aut Ahmed, Yasar Luqman verfasserin (DE-588)1155841832 (DE-627)101832612X (DE-576)501896260 aut Bange, Gert verfasserin (DE-588)135801354 (DE-627)57166489X (DE-576)300653719 aut Sinning, Irmgard 1960- verfasserin (DE-588)1027598617 (DE-627)72945133X (DE-576)166290580 aut Hurt, Ed 1955- verfasserin (DE-588)11021952X (DE-627)729291863 (DE-576)373308574 aut Enthalten in Cell [Cambridge, Mass.] : Cell Press, 1974 171(2017), 7, Seite 1599-1610 Online-Ressource (DE-627)320416127 (DE-600)2001951-8 (DE-576)090881370 1097-4172 nnns volume:171 year:2017 number:7 pages:1599-1610 extent:12 http://dx.doi.org/10.1016/j.cell.2017.11.039 Verlag Resolving-System kostenfrei Volltext http://www.sciencedirect.com/science/article/pii/S0092867417314290 Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 171 2017 7 1599-1610 12 2013 01 DE-16-250 301760344X 00 --%%-- --%%-- --%%-- --%%-- l01 16-07-18 2403 01 DE-LFER 3020630282 00 --%%-- --%%-- n --%%-- l01 13-08-18 2403 01 DE-LFER http://dx.doi.org/10.1016/j.cell.2017.11.039 2013 01 DE-16-250 00 s hd2017 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_12 2013 01 DE-16-250 03 s s_12 2013 01 DE-16-250 04 p (DE-627)1467675695 Thoms, Matthias 2013 01 DE-16-250 04 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_2 2013 01 DE-16-250 05 p (DE-627)1577627490 Ismail, Sherif 2013 01 DE-16-250 05 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_5 2013 01 DE-16-250 06 p (DE-627)1571895914 Ahmed, Yasar Luqman 2013 01 DE-16-250 06 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_6 2013 01 DE-16-250 07 p (DE-627)1443439061 Bange, Gert 2013 01 DE-16-250 07 k (DE-627)1416822720 Extern 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_7 2013 01 DE-16-250 08 p (DE-627)1443444928 Sinning, Irmgard 2013 01 DE-16-250 08 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 08 k (DE-627)1416737693 Exzellenzcluster Zelluläre Netzwerke (EXCCN) 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_10 2013 01 DE-16-250 09 p (DE-627)1443445231 Hurt, Ed 2013 01 DE-16-250 09 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 09 k (DE-627)1416737693 Exzellenzcluster Zelluläre Netzwerke (EXCCN) 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_11 |
allfieldsSound |
10.1016/j.cell.2017.11.039 doi (DE-627)1577627709 (DE-576)507627709 (DE-599)BSZ507627709 (OCoLC)1341013772 DE-627 ger DE-627 rda eng Kater, Lukas 1989- verfasserin (DE-588)1162857374 (DE-627)1026952204 (DE-576)507626559 aut Visualizing the assembly pathway of nucleolar pre-60S ribosomes Lukas Kater, Matthias Thoms, Clara Barrio-Garcia, Jingdong Cheng, Sherif Ismail, Yasar Luqman Ahmed, Gert Bange, Dieter Kressler, Otto Berninghausen, Irmgard Sinning, Ed Hurt, Roland Beckmann December 14, 2017 12 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 16.07.2018 Summary Eukaryotic 60S ribosomal subunits are comprised of three rRNAs and ∼50 ribosomal proteins. The initial steps of their formation take place in the nucleolus, but, owing to a lack of structural information, this process is poorly understood. Using cryo-EM, we solved structures of early 60S biogenesis intermediates at 3.3 Å to 4.5 Å resolution, thereby providing insights into their sequential folding and assembly pathway. Besides revealing distinct immature rRNA conformations, we map 25 assembly factors in six different assembly states. Notably, the Nsa1-Rrp1-Rpf1-Mak16 module stabilizes the solvent side of the 60S subunit, and the Erb1-Ytm1-Nop7 complex organizes and connects through Erb1’s meandering N-terminal extension, eight assembly factors, three ribosomal proteins, and three 25S rRNA domains. Our structural snapshots reveal the order of integration and compaction of the six major 60S domains within early nucleolar 60S particles developing stepwise from the solvent side around the exit tunnel to the central protuberance. cryo-electron microscopy assembly Erb1 large subunit assembly Nsa1 nucleolus pre-60S ribosome ribosome biogenesis Thoms, Matthias verfasserin (DE-588)1044453427 (DE-627)772066868 (DE-576)397675542 aut Ismail, Sherif 1991- verfasserin (DE-588)1162857668 (DE-627)1026952875 (DE-576)507626893 aut Ahmed, Yasar Luqman verfasserin (DE-588)1155841832 (DE-627)101832612X (DE-576)501896260 aut Bange, Gert verfasserin (DE-588)135801354 (DE-627)57166489X (DE-576)300653719 aut Sinning, Irmgard 1960- verfasserin (DE-588)1027598617 (DE-627)72945133X (DE-576)166290580 aut Hurt, Ed 1955- verfasserin (DE-588)11021952X (DE-627)729291863 (DE-576)373308574 aut Enthalten in Cell [Cambridge, Mass.] : Cell Press, 1974 171(2017), 7, Seite 1599-1610 Online-Ressource (DE-627)320416127 (DE-600)2001951-8 (DE-576)090881370 1097-4172 nnns volume:171 year:2017 number:7 pages:1599-1610 extent:12 http://dx.doi.org/10.1016/j.cell.2017.11.039 Verlag Resolving-System kostenfrei Volltext http://www.sciencedirect.com/science/article/pii/S0092867417314290 Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 171 2017 7 1599-1610 12 2013 01 DE-16-250 301760344X 00 --%%-- --%%-- --%%-- --%%-- l01 16-07-18 2403 01 DE-LFER 3020630282 00 --%%-- --%%-- n --%%-- l01 13-08-18 2403 01 DE-LFER http://dx.doi.org/10.1016/j.cell.2017.11.039 2013 01 DE-16-250 00 s hd2017 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_12 2013 01 DE-16-250 03 s s_12 2013 01 DE-16-250 04 p (DE-627)1467675695 Thoms, Matthias 2013 01 DE-16-250 04 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_2 2013 01 DE-16-250 05 p (DE-627)1577627490 Ismail, Sherif 2013 01 DE-16-250 05 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_5 2013 01 DE-16-250 06 p (DE-627)1571895914 Ahmed, Yasar Luqman 2013 01 DE-16-250 06 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_6 2013 01 DE-16-250 07 p (DE-627)1443439061 Bange, Gert 2013 01 DE-16-250 07 k (DE-627)1416822720 Extern 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_7 2013 01 DE-16-250 08 p (DE-627)1443444928 Sinning, Irmgard 2013 01 DE-16-250 08 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 08 k (DE-627)1416737693 Exzellenzcluster Zelluläre Netzwerke (EXCCN) 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_10 2013 01 DE-16-250 09 p (DE-627)1443445231 Hurt, Ed 2013 01 DE-16-250 09 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 09 k (DE-627)1416737693 Exzellenzcluster Zelluläre Netzwerke (EXCCN) 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_11 |
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Kater, Lukas @@aut@@ Thoms, Matthias @@aut@@ Ismail, Sherif @@aut@@ Ahmed, Yasar Luqman @@aut@@ Bange, Gert @@aut@@ Sinning, Irmgard @@aut@@ Hurt, Ed @@aut@@ |
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author |
Kater, Lukas 1989- |
spellingShingle |
Kater, Lukas 1989- misc cryo-electron microscopy misc assembly misc Erb1 misc large subunit assembly misc Nsa1 misc nucleolus misc pre-60S misc ribosome misc ribosome biogenesis 2013 hd2017 2013 wissenschaftlicher Artikel (Zeitschrift) 2013 per_12 2013 s_12 2013 Thoms, Matthias 2013 Biochemiezentrum der Universität Heidelberg (BZH) 2013 Verfasser 2013 pos_2 2013 Ismail, Sherif 2013 pos_5 2013 Ahmed, Yasar Luqman 2013 pos_6 2013 Bange, Gert 2013 Extern 2013 pos_7 2013 Sinning, Irmgard 2013 Exzellenzcluster Zelluläre Netzwerke (EXCCN) 2013 pos_10 2013 Hurt, Ed 2013 pos_11 Visualizing the assembly pathway of nucleolar pre-60S ribosomes |
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Kater, Lukas 1989- |
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2013@16-07-18 2403@13-08-18 |
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issn |
1097-4172 |
topic_title |
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topic |
misc cryo-electron microscopy misc assembly misc Erb1 misc large subunit assembly misc Nsa1 misc nucleolus misc pre-60S misc ribosome misc ribosome biogenesis 2013 hd2017 2013 wissenschaftlicher Artikel (Zeitschrift) 2013 per_12 2013 s_12 2013 Thoms, Matthias 2013 Biochemiezentrum der Universität Heidelberg (BZH) 2013 Verfasser 2013 pos_2 2013 Ismail, Sherif 2013 pos_5 2013 Ahmed, Yasar Luqman 2013 pos_6 2013 Bange, Gert 2013 Extern 2013 pos_7 2013 Sinning, Irmgard 2013 Exzellenzcluster Zelluläre Netzwerke (EXCCN) 2013 pos_10 2013 Hurt, Ed 2013 pos_11 |
topic_unstemmed |
misc cryo-electron microscopy misc assembly misc Erb1 misc large subunit assembly misc Nsa1 misc nucleolus misc pre-60S misc ribosome misc ribosome biogenesis 2013 hd2017 2013 wissenschaftlicher Artikel (Zeitschrift) 2013 per_12 2013 s_12 2013 Thoms, Matthias 2013 Biochemiezentrum der Universität Heidelberg (BZH) 2013 Verfasser 2013 pos_2 2013 Ismail, Sherif 2013 pos_5 2013 Ahmed, Yasar Luqman 2013 pos_6 2013 Bange, Gert 2013 Extern 2013 pos_7 2013 Sinning, Irmgard 2013 Exzellenzcluster Zelluläre Netzwerke (EXCCN) 2013 pos_10 2013 Hurt, Ed 2013 pos_11 |
topic_browse |
misc cryo-electron microscopy misc assembly misc Erb1 misc large subunit assembly misc Nsa1 misc nucleolus misc pre-60S misc ribosome misc ribosome biogenesis 2013 hd2017 2013 wissenschaftlicher Artikel (Zeitschrift) 2013 per_12 2013 s_12 2013 Thoms, Matthias 2013 Biochemiezentrum der Universität Heidelberg (BZH) 2013 Verfasser 2013 pos_2 2013 Ismail, Sherif 2013 pos_5 2013 Ahmed, Yasar Luqman 2013 pos_6 2013 Bange, Gert 2013 Extern 2013 pos_7 2013 Sinning, Irmgard 2013 Exzellenzcluster Zelluläre Netzwerke (EXCCN) 2013 pos_10 2013 Hurt, Ed 2013 pos_11 |
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Visualizing the assembly pathway of nucleolar pre-60S ribosomes |
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Visualizing the assembly pathway of nucleolar pre-60S ribosomes Lukas Kater, Matthias Thoms, Clara Barrio-Garcia, Jingdong Cheng, Sherif Ismail, Yasar Luqman Ahmed, Gert Bange, Dieter Kressler, Otto Berninghausen, Irmgard Sinning, Ed Hurt, Roland Beckmann |
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Visualizing the assembly pathway of nucleolar pre-60S ribosomes |
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Summary Eukaryotic 60S ribosomal subunits are comprised of three rRNAs and ∼50 ribosomal proteins. The initial steps of their formation take place in the nucleolus, but, owing to a lack of structural information, this process is poorly understood. Using cryo-EM, we solved structures of early 60S biogenesis intermediates at 3.3 Å to 4.5 Å resolution, thereby providing insights into their sequential folding and assembly pathway. Besides revealing distinct immature rRNA conformations, we map 25 assembly factors in six different assembly states. Notably, the Nsa1-Rrp1-Rpf1-Mak16 module stabilizes the solvent side of the 60S subunit, and the Erb1-Ytm1-Nop7 complex organizes and connects through Erb1’s meandering N-terminal extension, eight assembly factors, three ribosomal proteins, and three 25S rRNA domains. Our structural snapshots reveal the order of integration and compaction of the six major 60S domains within early nucleolar 60S particles developing stepwise from the solvent side around the exit tunnel to the central protuberance. Gesehen am 16.07.2018 |
abstractGer |
Summary Eukaryotic 60S ribosomal subunits are comprised of three rRNAs and ∼50 ribosomal proteins. The initial steps of their formation take place in the nucleolus, but, owing to a lack of structural information, this process is poorly understood. Using cryo-EM, we solved structures of early 60S biogenesis intermediates at 3.3 Å to 4.5 Å resolution, thereby providing insights into their sequential folding and assembly pathway. Besides revealing distinct immature rRNA conformations, we map 25 assembly factors in six different assembly states. Notably, the Nsa1-Rrp1-Rpf1-Mak16 module stabilizes the solvent side of the 60S subunit, and the Erb1-Ytm1-Nop7 complex organizes and connects through Erb1’s meandering N-terminal extension, eight assembly factors, three ribosomal proteins, and three 25S rRNA domains. Our structural snapshots reveal the order of integration and compaction of the six major 60S domains within early nucleolar 60S particles developing stepwise from the solvent side around the exit tunnel to the central protuberance. Gesehen am 16.07.2018 |
abstract_unstemmed |
Summary Eukaryotic 60S ribosomal subunits are comprised of three rRNAs and ∼50 ribosomal proteins. The initial steps of their formation take place in the nucleolus, but, owing to a lack of structural information, this process is poorly understood. Using cryo-EM, we solved structures of early 60S biogenesis intermediates at 3.3 Å to 4.5 Å resolution, thereby providing insights into their sequential folding and assembly pathway. Besides revealing distinct immature rRNA conformations, we map 25 assembly factors in six different assembly states. Notably, the Nsa1-Rrp1-Rpf1-Mak16 module stabilizes the solvent side of the 60S subunit, and the Erb1-Ytm1-Nop7 complex organizes and connects through Erb1’s meandering N-terminal extension, eight assembly factors, three ribosomal proteins, and three 25S rRNA domains. Our structural snapshots reveal the order of integration and compaction of the six major 60S domains within early nucleolar 60S particles developing stepwise from the solvent side around the exit tunnel to the central protuberance. Gesehen am 16.07.2018 |
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Visualizing the assembly pathway of nucleolar pre-60S ribosomes |
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