Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010 : a systematic analysis for the Global Burden of Disease Study 2010
<h2>Summary</h2><h3>Background</h3><p>Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the onl...
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| Autor*in: |
Vos, Theo [verfasserIn] Jonas, Jost B. - 1958- [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
14 December 2012 |
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| Anmerkung: |
"This online publication has been corrected The corrected version first appeared at thelancet.com on February 22, 2012, the second corrected version appeared on August 15, 2014" Gesehen am 20.07.2018 |
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| Umfang: |
Diagramme 34 |
| Weitere Ausgabe: |
Erscheint auch als Druck-Ausgabe: Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990 - 2010 - 2012 |
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| Übergeordnetes Werk: |
Enthalten in: The lancet - London [u.a.] : Elsevier, 1823, 380(2012), 9859, Seite 2163-2196 |
| Übergeordnetes Werk: |
volume:380 ; year:2012 ; number:9859 ; pages:2163-2196 ; extent:34 |
| Links: |
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| DOI / URN: |
10.1016/S0140-6736(12)61729-2 |
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| Katalog-ID: |
1577803825 |
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| 245 | 1 | 0 | |a Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010 |b a systematic analysis for the Global Burden of Disease Study 2010 |c Theo Vos, Abraham D. Flaxman, Mohsen Naghavi, Rafael Lozano, Catherine Michaud, Majid Ezzati, Kenji Shibuya, Joshua A. Salomon, Safa Abdalla, Victor Aboyans, Jerry Abraham, Ilana Ackerman, Rakesh Aggarwal, Stephanie Y. Ahn, Mohammed K. Ali, Mohammad A. AlMazroa, Miriam Alvarado, H. Ross Anderson, Laurie M. Anderson, Kathryn G. Andrews, Charles Atkinson, Larry M. Baddour, Adil N. Bahalim, Suzanne Barker-Collo, Lope H. Barrero, David H. Bartels, Maria-Gloria Basáñez, Amanda Baxter, Michelle L. Bell, Emelia J. Benjamin, Derrick Bennett, Eduardo Bernabé, Kavi Bhalla, Bishal Bhandari, Boris Bikbov, Aref Bin Abdulhak, Gretchen Birbeck, James A. Black, Hannah Blencowe, Jed D. Blore, Fiona Blyth, Ian Bolliger, Audrey Bonaventure, Soufiane Boufous, Rupert Bourne, Michel Boussinesq, Tasanee Braithwaite, Carol Brayne, Lisa Bridgett, Simon Brooker, Peter Brooks, Traolach S. Brugha, Claire Bryan-Hancock, Chiara Bucello, Rachelle Buchbinder, Geoffrey Buckle, Christine M. Budke, Michael Burch, Peter Burney, Roy Burstein, Bianca Calabria, Benjamin Campbell, Charles E. Canter, Hélène Carabin, Jonathan Carapetis, Loreto Carmona, Claudia Cella, Fiona Charlson, Honglei Chen, Andrew Tai-Ann Cheng, David Chou, Sumeet S. Chugh, Luc E. Coffeng, Steven D. Colan, Samantha Colquhoun, K. Ellicott Colson, John Condon, Myles D. Connor, Leslie T. Cooper, Matthew Corriere, Monica Cortinovis, Karen Courville de Vaccaro, William Couser, Benjamin C. Cowie, Michael H. Criqui, Marita Cross, Kaustubh C. Dabhadkar, Manu Dahiya, Nabila Dahodwala, James Damsere-Derry, Goodarz Danaei, Adrian Davis, Diego De Leo, Louisa Degenhardt, Robert Dellavalle, Allyne Delossantos, Julie Denenberg, Sarah Derrett, Don C. Des Jarlais, Samath D. Dharmaratne, Mukesh Dherani, Cesar Diaz-Torne, Helen Dolk, E. Ray Dorsey, Tim Driscoll, Herbert Duber, Beth Ebel, Karen Edmond, Alexis Elbaz, Suad Eltahir Ali, Holly Erskine, Patricia J. Erwin, Patricia Espindola, Stalin E. Ewoigbokhan, Farshad Farzadfar, Valery Feigin, David T. Felson, Alize Ferrari, Cleusa P. Ferri, Eric M. Fèvre, Mariel M. Finucane, Seth Flaxman, Louise Flood, Kyle Foreman, Mohammad H. Forouzanfar, Francis Gerry R. Fowkes, Richard Franklin, Marlene Fransen, Michael K. Freeman, Belinda J. Gabbe, Sherine E. Gabriel, Emmanuela Gakidou, Hammad A. Ganatra, Bianca Garcia, Flavio Gaspari, Richard F. Gillum, Gerhard Gmel, Richard Gosselin, Rebecca Grainger, Justina Groeger, Francis Guillemin, David Gunnell, Ramyani Gupta, Juanita Haagsma, Holly Hagan, Yara A. Halasa, Wayne Hall, Diana Haring, Josep Maria Haro, James E. Harrison, Rasmus Havmoeller, Roderick J. Hay, Hideki Higashi, Catherine Hill, Bruno Hoen, Howard Hoffman, Peter J. Hotez, Damian Hoy, John J. Huang, Sydney E. Ibeanusi, Kathryn H. Jacobsen, Spencer L. James, Deborah Jarvis, Rashmi Jasrasaria, Sudha Jayaraman, Nicole Johns, Jost B. Jonas, Ganesan Karthikeyan, Nicholas Kassebaum, Norito Kawakami, Andre Keren, Jon-Paul Khoo, Charles H. King, Lisa Marie Knowlton, Olive Kobusingye, Adofo Koranteng, Rita Krishnamurthi, Ratilal Lalloo, Laura L. Laslett, Tim Lathlean, Janet L. Leasher, Yong Yi Lee, James Leigh, Stephen S. Lim, Elizabeth Limb, John Kent Lin, Michael Lipnick, Steven E. Lipshultz, Wei Liu, Maria Loane, Summer Lockett Ohno, Ronan Lyons, Jixiang Ma, Jacqueline Mabweijano, Michael F. MacIntyre, Reza Malekzadeh, Leslie Mallinger, Sivabalan Manivannan, Wagner Marcenes, Lyn March, David J. Margolis, Guy B. Marks, Robin Marks, Akira Matsumori, Richard Matzopoulos, Bongani M. Mayosi, John H. McAnulty, Mary M. McDermott, Neil McGill, John McGrath, Maria Elena Medina-Mora, Michele Meltzer, Ziad A. Memish, George A. Mensah, Tony R. Merriman, Ana-Claire Meyer, Valeria Miglioli, Matthew Miller, Ted R. Miller, Philip B. Mitchell, Ana Olga Mocumbi, Terrie E. Moffitt, Ali A. Mokdad, Lorenzo Monasta, Marcella Montico, Maziar Moradi-Lakeh, Andrew Moran, Lidia Morawska, Rintaro Mori, Michele E. Murdoch, Michael K. Mwaniki, Kovin Naidoo, M. Nathan Nair, Luigi Naldi, KM Venkat Narayan, Paul K. Nelson, Robert G. Nelson, Michael C. Nevitt, Charles R. Newton, Sandra Nolte, Paul Norman, Rosana Norman, Martin O'Donnell, Simon O'Hanlon, Casey Olives, Saad B. Omer, Katrina Ortblad, Richard Osborne, Doruk Ozgediz, Andrew Page, Bishnu Pahari, Jeyaraj Durai Pandian, Andrea Panozo Rivero, Scott B. Patten, Neil Pearce, Rogelio Perez Padilla, Fernando Perez-Ruiz, Norberto Perico, Konrad Pesudovs, David Phillips, Michael R. Phillips, Kelsey Pierce, Sébastien Pion, Guilherme V. Polanczyk, Suzanne Polinder, C. Arden Pope, Svetlana Popova, Esteban Porrini, Farshad Pourmalek, Martin Prince, Rachel L. Pullan, Kapa D. Ramaiah, Dharani Ranganathan, Homie Razavi, Mathilda Regan, Jürgen T. Rehm, David B. Rein, Guiseppe Remuzzi, Kathryn Richardson, Frederick P. Rivara, Thomas Roberts, Carolyn Robinson, Felipe Rodriguez De Leòn, Luca Ronfani, Robin Room, Lisa C. Rosenfeld, Lesley Rushton, Ralph L. Sacco, Sukanta Saha, Uchechukwu Sampson, Lidia Sanchez-Riera, Ella Sanman, David C. Schwebel, James Graham Scott, Maria Segui-Gomez, Saeid Shahraz, Donald S. Shepard, Hwashin Shin, Rupak Shivakoti, Donald Silberberg, David Singh, Gitanjali M. Singh, Jasvinder A. Singh, Jessica Singleton, David A. Sleet, Karen Sliwa, Emma Smith, Jennifer L. Smith, Nicolas JC Stapelberg, Andrew Steer, Timothy Steiner, Wilma A. Stolk, Lars Jacob Stovner, Christopher Sudfeld, Sana Syed, Giorgio Tamburlini, Mohammad Tavakkoli, Hugh R. Taylor, Jennifer A. Taylor, William J. Taylor, Bernadette Thomas, W. Murray Thomson, George D. Thurston, Imad M. Tleyjeh, Marcello Tonelli, Jeffrey A. Towbin, Thomas Truelsen, Miltiadis K. Tsilimbaris, Clotilde Ubeda, Eduardo A. Undurraga, Marieke J. van der Werf, Jim van Os, Monica S. Vavilala, N. Venketasubramanian, Mengru Wang, Wenzhi Wang, Kerrianne Watt, David J. Weatherall, Martin A. Weinstock, Robert Weintraub, Marc G. Weisskopf, Myrna M. Weissman, Richard A. White, Harvey Whiteford, Steven T. Wiersma, James D. Wilkinson, Hywel C. Williams, Sean RM Williams, Emma Witt, Frederick Wolfe, Anthony D. Woolf, Sarah Wulf, Pon-Hsiu Yeh, Anita KM Zaidi, Zhi-Jie Zheng, David Zonies, Alan D. Lopez, Christopher JL Murray |
| 264 | 1 | |c 14 December 2012 | |
| 300 | |b Diagramme | ||
| 300 | |a 34 | ||
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| 500 | |a "This online publication has been corrected | ||
| 500 | |a The corrected version first appeared at thelancet.com on February 22, 2012, the second corrected version appeared on August 15, 2014" | ||
| 500 | |a Gesehen am 20.07.2018 | ||
| 520 | |a <h2>Summary</h2><h3>Background</h3><p>Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).</p><h3>Methods</h3><p>Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis.</p><h3>Findings</h3><p>Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient −0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa.</p><h3>Interpretation</h3><p>Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.</p><h3>Funding</h3><p>Bill & Melinda Gates Foundation.</p> | ||
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10.1016/S0140-6736(12)61729-2 doi (DE-627)1577803825 (DE-576)507803825 (DE-599)BSZ507803825 (OCoLC)1341014101 DE-627 ger DE-627 rda eng Vos, Theo verfasserin (DE-588)1123164436 (DE-627)880000031 (DE-576)48164685X aut Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010 a systematic analysis for the Global Burden of Disease Study 2010 Theo Vos, Abraham D. Flaxman, Mohsen Naghavi, Rafael Lozano, Catherine Michaud, Majid Ezzati, Kenji Shibuya, Joshua A. Salomon, Safa Abdalla, Victor Aboyans, Jerry Abraham, Ilana Ackerman, Rakesh Aggarwal, Stephanie Y. Ahn, Mohammed K. Ali, Mohammad A. AlMazroa, Miriam Alvarado, H. Ross Anderson, Laurie M. Anderson, Kathryn G. Andrews, Charles Atkinson, Larry M. Baddour, Adil N. Bahalim, Suzanne Barker-Collo, Lope H. Barrero, David H. Bartels, Maria-Gloria Basáñez, Amanda Baxter, Michelle L. Bell, Emelia J. Benjamin, Derrick Bennett, Eduardo Bernabé, Kavi Bhalla, Bishal Bhandari, Boris Bikbov, Aref Bin Abdulhak, Gretchen Birbeck, James A. Black, Hannah Blencowe, Jed D. Blore, Fiona Blyth, Ian Bolliger, Audrey Bonaventure, Soufiane Boufous, Rupert Bourne, Michel Boussinesq, Tasanee Braithwaite, Carol Brayne, Lisa Bridgett, Simon Brooker, Peter Brooks, Traolach S. Brugha, Claire Bryan-Hancock, Chiara Bucello, Rachelle Buchbinder, Geoffrey Buckle, Christine M. Budke, Michael Burch, Peter Burney, Roy Burstein, Bianca Calabria, Benjamin Campbell, Charles E. Canter, Hélène Carabin, Jonathan Carapetis, Loreto Carmona, Claudia Cella, Fiona Charlson, Honglei Chen, Andrew Tai-Ann Cheng, David Chou, Sumeet S. Chugh, Luc E. Coffeng, Steven D. Colan, Samantha Colquhoun, K. Ellicott Colson, John Condon, Myles D. Connor, Leslie T. Cooper, Matthew Corriere, Monica Cortinovis, Karen Courville de Vaccaro, William Couser, Benjamin C. Cowie, Michael H. Criqui, Marita Cross, Kaustubh C. Dabhadkar, Manu Dahiya, Nabila Dahodwala, James Damsere-Derry, Goodarz Danaei, Adrian Davis, Diego De Leo, Louisa Degenhardt, Robert Dellavalle, Allyne Delossantos, Julie Denenberg, Sarah Derrett, Don C. Des Jarlais, Samath D. Dharmaratne, Mukesh Dherani, Cesar Diaz-Torne, Helen Dolk, E. Ray Dorsey, Tim Driscoll, Herbert Duber, Beth Ebel, Karen Edmond, Alexis Elbaz, Suad Eltahir Ali, Holly Erskine, Patricia J. Erwin, Patricia Espindola, Stalin E. Ewoigbokhan, Farshad Farzadfar, Valery Feigin, David T. Felson, Alize Ferrari, Cleusa P. Ferri, Eric M. Fèvre, Mariel M. Finucane, Seth Flaxman, Louise Flood, Kyle Foreman, Mohammad H. Forouzanfar, Francis Gerry R. Fowkes, Richard Franklin, Marlene Fransen, Michael K. Freeman, Belinda J. Gabbe, Sherine E. Gabriel, Emmanuela Gakidou, Hammad A. Ganatra, Bianca Garcia, Flavio Gaspari, Richard F. Gillum, Gerhard Gmel, Richard Gosselin, Rebecca Grainger, Justina Groeger, Francis Guillemin, David Gunnell, Ramyani Gupta, Juanita Haagsma, Holly Hagan, Yara A. Halasa, Wayne Hall, Diana Haring, Josep Maria Haro, James E. Harrison, Rasmus Havmoeller, Roderick J. Hay, Hideki Higashi, Catherine Hill, Bruno Hoen, Howard Hoffman, Peter J. Hotez, Damian Hoy, John J. Huang, Sydney E. Ibeanusi, Kathryn H. Jacobsen, Spencer L. James, Deborah Jarvis, Rashmi Jasrasaria, Sudha Jayaraman, Nicole Johns, Jost B. Jonas, Ganesan Karthikeyan, Nicholas Kassebaum, Norito Kawakami, Andre Keren, Jon-Paul Khoo, Charles H. King, Lisa Marie Knowlton, Olive Kobusingye, Adofo Koranteng, Rita Krishnamurthi, Ratilal Lalloo, Laura L. Laslett, Tim Lathlean, Janet L. Leasher, Yong Yi Lee, James Leigh, Stephen S. Lim, Elizabeth Limb, John Kent Lin, Michael Lipnick, Steven E. Lipshultz, Wei Liu, Maria Loane, Summer Lockett Ohno, Ronan Lyons, Jixiang Ma, Jacqueline Mabweijano, Michael F. MacIntyre, Reza Malekzadeh, Leslie Mallinger, Sivabalan Manivannan, Wagner Marcenes, Lyn March, David J. Margolis, Guy B. Marks, Robin Marks, Akira Matsumori, Richard Matzopoulos, Bongani M. Mayosi, John H. McAnulty, Mary M. McDermott, Neil McGill, John McGrath, Maria Elena Medina-Mora, Michele Meltzer, Ziad A. Memish, George A. Mensah, Tony R. Merriman, Ana-Claire Meyer, Valeria Miglioli, Matthew Miller, Ted R. Miller, Philip B. Mitchell, Ana Olga Mocumbi, Terrie E. Moffitt, Ali A. Mokdad, Lorenzo Monasta, Marcella Montico, Maziar Moradi-Lakeh, Andrew Moran, Lidia Morawska, Rintaro Mori, Michele E. Murdoch, Michael K. Mwaniki, Kovin Naidoo, M. Nathan Nair, Luigi Naldi, KM Venkat Narayan, Paul K. Nelson, Robert G. Nelson, Michael C. Nevitt, Charles R. Newton, Sandra Nolte, Paul Norman, Rosana Norman, Martin O'Donnell, Simon O'Hanlon, Casey Olives, Saad B. Omer, Katrina Ortblad, Richard Osborne, Doruk Ozgediz, Andrew Page, Bishnu Pahari, Jeyaraj Durai Pandian, Andrea Panozo Rivero, Scott B. Patten, Neil Pearce, Rogelio Perez Padilla, Fernando Perez-Ruiz, Norberto Perico, Konrad Pesudovs, David Phillips, Michael R. Phillips, Kelsey Pierce, Sébastien Pion, Guilherme V. Polanczyk, Suzanne Polinder, C. Arden Pope, Svetlana Popova, Esteban Porrini, Farshad Pourmalek, Martin Prince, Rachel L. Pullan, Kapa D. Ramaiah, Dharani Ranganathan, Homie Razavi, Mathilda Regan, Jürgen T. Rehm, David B. Rein, Guiseppe Remuzzi, Kathryn Richardson, Frederick P. Rivara, Thomas Roberts, Carolyn Robinson, Felipe Rodriguez De Leòn, Luca Ronfani, Robin Room, Lisa C. Rosenfeld, Lesley Rushton, Ralph L. Sacco, Sukanta Saha, Uchechukwu Sampson, Lidia Sanchez-Riera, Ella Sanman, David C. Schwebel, James Graham Scott, Maria Segui-Gomez, Saeid Shahraz, Donald S. Shepard, Hwashin Shin, Rupak Shivakoti, Donald Silberberg, David Singh, Gitanjali M. Singh, Jasvinder A. Singh, Jessica Singleton, David A. Sleet, Karen Sliwa, Emma Smith, Jennifer L. Smith, Nicolas JC Stapelberg, Andrew Steer, Timothy Steiner, Wilma A. Stolk, Lars Jacob Stovner, Christopher Sudfeld, Sana Syed, Giorgio Tamburlini, Mohammad Tavakkoli, Hugh R. Taylor, Jennifer A. Taylor, William J. Taylor, Bernadette Thomas, W. Murray Thomson, George D. Thurston, Imad M. Tleyjeh, Marcello Tonelli, Jeffrey A. Towbin, Thomas Truelsen, Miltiadis K. Tsilimbaris, Clotilde Ubeda, Eduardo A. Undurraga, Marieke J. van der Werf, Jim van Os, Monica S. Vavilala, N. Venketasubramanian, Mengru Wang, Wenzhi Wang, Kerrianne Watt, David J. Weatherall, Martin A. Weinstock, Robert Weintraub, Marc G. Weisskopf, Myrna M. Weissman, Richard A. White, Harvey Whiteford, Steven T. Wiersma, James D. Wilkinson, Hywel C. Williams, Sean RM Williams, Emma Witt, Frederick Wolfe, Anthony D. Woolf, Sarah Wulf, Pon-Hsiu Yeh, Anita KM Zaidi, Zhi-Jie Zheng, David Zonies, Alan D. Lopez, Christopher JL Murray 14 December 2012 Diagramme 34 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier "This online publication has been corrected The corrected version first appeared at thelancet.com on February 22, 2012, the second corrected version appeared on August 15, 2014" Gesehen am 20.07.2018 <h2>Summary</h2><h3>Background</h3><p>Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).</p><h3>Methods</h3><p>Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis.</p><h3>Findings</h3><p>Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient −0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa.</p><h3>Interpretation</h3><p>Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.</p><h3>Funding</h3><p>Bill & Melinda Gates Foundation.</p> Jonas, Jost B. 1958- verfasserin (DE-588)1028286732 (DE-627)730536823 (DE-576)37578537X aut Enthalten in The lancet London [u.a.] : Elsevier, 1823 380(2012), 9859, Seite 2163-2196 Online-Ressource (DE-627)270128484 (DE-600)1476593-7 (DE-576)078590159 1474-547X nnns volume:380 year:2012 number:9859 pages:2163-2196 extent:34 Erscheint auch als Druck-Ausgabe Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990 - 2010 2012 (DE-627)1449891292 (DE-576)379891298 http://dx.doi.org/10.1016/S0140-6736(12)61729-2 Verlag Resolving-System Volltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61729-2/abstract Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 380 2012 9859 2163-2196 34 2013 01 DE-16-250 3019144531 00 --%%-- --%%-- --%%-- --%%-- l01 20-07-18 2013 01 DE-16-250 00 s hd2012 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_358 2013 01 DE-16-250 03 s s_34 2013 01 DE-16-250 04 p (DE-627)1445785498 Jonas, Jost B. 2013 01 DE-16-250 04 k (DE-627)1416741186 Universitäts-Augenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_167 |
| spelling |
10.1016/S0140-6736(12)61729-2 doi (DE-627)1577803825 (DE-576)507803825 (DE-599)BSZ507803825 (OCoLC)1341014101 DE-627 ger DE-627 rda eng Vos, Theo verfasserin (DE-588)1123164436 (DE-627)880000031 (DE-576)48164685X aut Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010 a systematic analysis for the Global Burden of Disease Study 2010 Theo Vos, Abraham D. Flaxman, Mohsen Naghavi, Rafael Lozano, Catherine Michaud, Majid Ezzati, Kenji Shibuya, Joshua A. Salomon, Safa Abdalla, Victor Aboyans, Jerry Abraham, Ilana Ackerman, Rakesh Aggarwal, Stephanie Y. Ahn, Mohammed K. Ali, Mohammad A. AlMazroa, Miriam Alvarado, H. Ross Anderson, Laurie M. Anderson, Kathryn G. Andrews, Charles Atkinson, Larry M. Baddour, Adil N. Bahalim, Suzanne Barker-Collo, Lope H. Barrero, David H. Bartels, Maria-Gloria Basáñez, Amanda Baxter, Michelle L. Bell, Emelia J. Benjamin, Derrick Bennett, Eduardo Bernabé, Kavi Bhalla, Bishal Bhandari, Boris Bikbov, Aref Bin Abdulhak, Gretchen Birbeck, James A. Black, Hannah Blencowe, Jed D. Blore, Fiona Blyth, Ian Bolliger, Audrey Bonaventure, Soufiane Boufous, Rupert Bourne, Michel Boussinesq, Tasanee Braithwaite, Carol Brayne, Lisa Bridgett, Simon Brooker, Peter Brooks, Traolach S. Brugha, Claire Bryan-Hancock, Chiara Bucello, Rachelle Buchbinder, Geoffrey Buckle, Christine M. Budke, Michael Burch, Peter Burney, Roy Burstein, Bianca Calabria, Benjamin Campbell, Charles E. Canter, Hélène Carabin, Jonathan Carapetis, Loreto Carmona, Claudia Cella, Fiona Charlson, Honglei Chen, Andrew Tai-Ann Cheng, David Chou, Sumeet S. Chugh, Luc E. Coffeng, Steven D. Colan, Samantha Colquhoun, K. Ellicott Colson, John Condon, Myles D. Connor, Leslie T. Cooper, Matthew Corriere, Monica Cortinovis, Karen Courville de Vaccaro, William Couser, Benjamin C. Cowie, Michael H. Criqui, Marita Cross, Kaustubh C. Dabhadkar, Manu Dahiya, Nabila Dahodwala, James Damsere-Derry, Goodarz Danaei, Adrian Davis, Diego De Leo, Louisa Degenhardt, Robert Dellavalle, Allyne Delossantos, Julie Denenberg, Sarah Derrett, Don C. Des Jarlais, Samath D. Dharmaratne, Mukesh Dherani, Cesar Diaz-Torne, Helen Dolk, E. Ray Dorsey, Tim Driscoll, Herbert Duber, Beth Ebel, Karen Edmond, Alexis Elbaz, Suad Eltahir Ali, Holly Erskine, Patricia J. Erwin, Patricia Espindola, Stalin E. Ewoigbokhan, Farshad Farzadfar, Valery Feigin, David T. Felson, Alize Ferrari, Cleusa P. Ferri, Eric M. Fèvre, Mariel M. Finucane, Seth Flaxman, Louise Flood, Kyle Foreman, Mohammad H. Forouzanfar, Francis Gerry R. Fowkes, Richard Franklin, Marlene Fransen, Michael K. Freeman, Belinda J. Gabbe, Sherine E. Gabriel, Emmanuela Gakidou, Hammad A. Ganatra, Bianca Garcia, Flavio Gaspari, Richard F. Gillum, Gerhard Gmel, Richard Gosselin, Rebecca Grainger, Justina Groeger, Francis Guillemin, David Gunnell, Ramyani Gupta, Juanita Haagsma, Holly Hagan, Yara A. Halasa, Wayne Hall, Diana Haring, Josep Maria Haro, James E. Harrison, Rasmus Havmoeller, Roderick J. Hay, Hideki Higashi, Catherine Hill, Bruno Hoen, Howard Hoffman, Peter J. Hotez, Damian Hoy, John J. Huang, Sydney E. Ibeanusi, Kathryn H. Jacobsen, Spencer L. James, Deborah Jarvis, Rashmi Jasrasaria, Sudha Jayaraman, Nicole Johns, Jost B. Jonas, Ganesan Karthikeyan, Nicholas Kassebaum, Norito Kawakami, Andre Keren, Jon-Paul Khoo, Charles H. King, Lisa Marie Knowlton, Olive Kobusingye, Adofo Koranteng, Rita Krishnamurthi, Ratilal Lalloo, Laura L. Laslett, Tim Lathlean, Janet L. Leasher, Yong Yi Lee, James Leigh, Stephen S. Lim, Elizabeth Limb, John Kent Lin, Michael Lipnick, Steven E. Lipshultz, Wei Liu, Maria Loane, Summer Lockett Ohno, Ronan Lyons, Jixiang Ma, Jacqueline Mabweijano, Michael F. MacIntyre, Reza Malekzadeh, Leslie Mallinger, Sivabalan Manivannan, Wagner Marcenes, Lyn March, David J. Margolis, Guy B. Marks, Robin Marks, Akira Matsumori, Richard Matzopoulos, Bongani M. Mayosi, John H. McAnulty, Mary M. McDermott, Neil McGill, John McGrath, Maria Elena Medina-Mora, Michele Meltzer, Ziad A. Memish, George A. Mensah, Tony R. Merriman, Ana-Claire Meyer, Valeria Miglioli, Matthew Miller, Ted R. Miller, Philip B. Mitchell, Ana Olga Mocumbi, Terrie E. Moffitt, Ali A. Mokdad, Lorenzo Monasta, Marcella Montico, Maziar Moradi-Lakeh, Andrew Moran, Lidia Morawska, Rintaro Mori, Michele E. Murdoch, Michael K. Mwaniki, Kovin Naidoo, M. Nathan Nair, Luigi Naldi, KM Venkat Narayan, Paul K. Nelson, Robert G. Nelson, Michael C. Nevitt, Charles R. Newton, Sandra Nolte, Paul Norman, Rosana Norman, Martin O'Donnell, Simon O'Hanlon, Casey Olives, Saad B. Omer, Katrina Ortblad, Richard Osborne, Doruk Ozgediz, Andrew Page, Bishnu Pahari, Jeyaraj Durai Pandian, Andrea Panozo Rivero, Scott B. Patten, Neil Pearce, Rogelio Perez Padilla, Fernando Perez-Ruiz, Norberto Perico, Konrad Pesudovs, David Phillips, Michael R. Phillips, Kelsey Pierce, Sébastien Pion, Guilherme V. Polanczyk, Suzanne Polinder, C. Arden Pope, Svetlana Popova, Esteban Porrini, Farshad Pourmalek, Martin Prince, Rachel L. Pullan, Kapa D. Ramaiah, Dharani Ranganathan, Homie Razavi, Mathilda Regan, Jürgen T. Rehm, David B. Rein, Guiseppe Remuzzi, Kathryn Richardson, Frederick P. Rivara, Thomas Roberts, Carolyn Robinson, Felipe Rodriguez De Leòn, Luca Ronfani, Robin Room, Lisa C. Rosenfeld, Lesley Rushton, Ralph L. Sacco, Sukanta Saha, Uchechukwu Sampson, Lidia Sanchez-Riera, Ella Sanman, David C. Schwebel, James Graham Scott, Maria Segui-Gomez, Saeid Shahraz, Donald S. Shepard, Hwashin Shin, Rupak Shivakoti, Donald Silberberg, David Singh, Gitanjali M. Singh, Jasvinder A. Singh, Jessica Singleton, David A. Sleet, Karen Sliwa, Emma Smith, Jennifer L. Smith, Nicolas JC Stapelberg, Andrew Steer, Timothy Steiner, Wilma A. Stolk, Lars Jacob Stovner, Christopher Sudfeld, Sana Syed, Giorgio Tamburlini, Mohammad Tavakkoli, Hugh R. Taylor, Jennifer A. Taylor, William J. Taylor, Bernadette Thomas, W. Murray Thomson, George D. Thurston, Imad M. Tleyjeh, Marcello Tonelli, Jeffrey A. Towbin, Thomas Truelsen, Miltiadis K. Tsilimbaris, Clotilde Ubeda, Eduardo A. Undurraga, Marieke J. van der Werf, Jim van Os, Monica S. Vavilala, N. Venketasubramanian, Mengru Wang, Wenzhi Wang, Kerrianne Watt, David J. Weatherall, Martin A. Weinstock, Robert Weintraub, Marc G. Weisskopf, Myrna M. Weissman, Richard A. White, Harvey Whiteford, Steven T. Wiersma, James D. Wilkinson, Hywel C. Williams, Sean RM Williams, Emma Witt, Frederick Wolfe, Anthony D. Woolf, Sarah Wulf, Pon-Hsiu Yeh, Anita KM Zaidi, Zhi-Jie Zheng, David Zonies, Alan D. Lopez, Christopher JL Murray 14 December 2012 Diagramme 34 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier "This online publication has been corrected The corrected version first appeared at thelancet.com on February 22, 2012, the second corrected version appeared on August 15, 2014" Gesehen am 20.07.2018 <h2>Summary</h2><h3>Background</h3><p>Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).</p><h3>Methods</h3><p>Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis.</p><h3>Findings</h3><p>Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient −0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa.</p><h3>Interpretation</h3><p>Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.</p><h3>Funding</h3><p>Bill & Melinda Gates Foundation.</p> Jonas, Jost B. 1958- verfasserin (DE-588)1028286732 (DE-627)730536823 (DE-576)37578537X aut Enthalten in The lancet London [u.a.] : Elsevier, 1823 380(2012), 9859, Seite 2163-2196 Online-Ressource (DE-627)270128484 (DE-600)1476593-7 (DE-576)078590159 1474-547X nnns volume:380 year:2012 number:9859 pages:2163-2196 extent:34 Erscheint auch als Druck-Ausgabe Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990 - 2010 2012 (DE-627)1449891292 (DE-576)379891298 http://dx.doi.org/10.1016/S0140-6736(12)61729-2 Verlag Resolving-System Volltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61729-2/abstract Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 380 2012 9859 2163-2196 34 2013 01 DE-16-250 3019144531 00 --%%-- --%%-- --%%-- --%%-- l01 20-07-18 2013 01 DE-16-250 00 s hd2012 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_358 2013 01 DE-16-250 03 s s_34 2013 01 DE-16-250 04 p (DE-627)1445785498 Jonas, Jost B. 2013 01 DE-16-250 04 k (DE-627)1416741186 Universitäts-Augenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_167 |
| allfields_unstemmed |
10.1016/S0140-6736(12)61729-2 doi (DE-627)1577803825 (DE-576)507803825 (DE-599)BSZ507803825 (OCoLC)1341014101 DE-627 ger DE-627 rda eng Vos, Theo verfasserin (DE-588)1123164436 (DE-627)880000031 (DE-576)48164685X aut Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010 a systematic analysis for the Global Burden of Disease Study 2010 Theo Vos, Abraham D. Flaxman, Mohsen Naghavi, Rafael Lozano, Catherine Michaud, Majid Ezzati, Kenji Shibuya, Joshua A. Salomon, Safa Abdalla, Victor Aboyans, Jerry Abraham, Ilana Ackerman, Rakesh Aggarwal, Stephanie Y. Ahn, Mohammed K. Ali, Mohammad A. AlMazroa, Miriam Alvarado, H. Ross Anderson, Laurie M. Anderson, Kathryn G. Andrews, Charles Atkinson, Larry M. Baddour, Adil N. Bahalim, Suzanne Barker-Collo, Lope H. Barrero, David H. Bartels, Maria-Gloria Basáñez, Amanda Baxter, Michelle L. Bell, Emelia J. Benjamin, Derrick Bennett, Eduardo Bernabé, Kavi Bhalla, Bishal Bhandari, Boris Bikbov, Aref Bin Abdulhak, Gretchen Birbeck, James A. Black, Hannah Blencowe, Jed D. Blore, Fiona Blyth, Ian Bolliger, Audrey Bonaventure, Soufiane Boufous, Rupert Bourne, Michel Boussinesq, Tasanee Braithwaite, Carol Brayne, Lisa Bridgett, Simon Brooker, Peter Brooks, Traolach S. Brugha, Claire Bryan-Hancock, Chiara Bucello, Rachelle Buchbinder, Geoffrey Buckle, Christine M. Budke, Michael Burch, Peter Burney, Roy Burstein, Bianca Calabria, Benjamin Campbell, Charles E. Canter, Hélène Carabin, Jonathan Carapetis, Loreto Carmona, Claudia Cella, Fiona Charlson, Honglei Chen, Andrew Tai-Ann Cheng, David Chou, Sumeet S. Chugh, Luc E. Coffeng, Steven D. Colan, Samantha Colquhoun, K. Ellicott Colson, John Condon, Myles D. Connor, Leslie T. Cooper, Matthew Corriere, Monica Cortinovis, Karen Courville de Vaccaro, William Couser, Benjamin C. Cowie, Michael H. Criqui, Marita Cross, Kaustubh C. Dabhadkar, Manu Dahiya, Nabila Dahodwala, James Damsere-Derry, Goodarz Danaei, Adrian Davis, Diego De Leo, Louisa Degenhardt, Robert Dellavalle, Allyne Delossantos, Julie Denenberg, Sarah Derrett, Don C. Des Jarlais, Samath D. Dharmaratne, Mukesh Dherani, Cesar Diaz-Torne, Helen Dolk, E. Ray Dorsey, Tim Driscoll, Herbert Duber, Beth Ebel, Karen Edmond, Alexis Elbaz, Suad Eltahir Ali, Holly Erskine, Patricia J. Erwin, Patricia Espindola, Stalin E. Ewoigbokhan, Farshad Farzadfar, Valery Feigin, David T. Felson, Alize Ferrari, Cleusa P. Ferri, Eric M. Fèvre, Mariel M. Finucane, Seth Flaxman, Louise Flood, Kyle Foreman, Mohammad H. Forouzanfar, Francis Gerry R. Fowkes, Richard Franklin, Marlene Fransen, Michael K. Freeman, Belinda J. Gabbe, Sherine E. Gabriel, Emmanuela Gakidou, Hammad A. Ganatra, Bianca Garcia, Flavio Gaspari, Richard F. Gillum, Gerhard Gmel, Richard Gosselin, Rebecca Grainger, Justina Groeger, Francis Guillemin, David Gunnell, Ramyani Gupta, Juanita Haagsma, Holly Hagan, Yara A. Halasa, Wayne Hall, Diana Haring, Josep Maria Haro, James E. Harrison, Rasmus Havmoeller, Roderick J. Hay, Hideki Higashi, Catherine Hill, Bruno Hoen, Howard Hoffman, Peter J. Hotez, Damian Hoy, John J. Huang, Sydney E. Ibeanusi, Kathryn H. Jacobsen, Spencer L. James, Deborah Jarvis, Rashmi Jasrasaria, Sudha Jayaraman, Nicole Johns, Jost B. Jonas, Ganesan Karthikeyan, Nicholas Kassebaum, Norito Kawakami, Andre Keren, Jon-Paul Khoo, Charles H. King, Lisa Marie Knowlton, Olive Kobusingye, Adofo Koranteng, Rita Krishnamurthi, Ratilal Lalloo, Laura L. Laslett, Tim Lathlean, Janet L. Leasher, Yong Yi Lee, James Leigh, Stephen S. Lim, Elizabeth Limb, John Kent Lin, Michael Lipnick, Steven E. Lipshultz, Wei Liu, Maria Loane, Summer Lockett Ohno, Ronan Lyons, Jixiang Ma, Jacqueline Mabweijano, Michael F. MacIntyre, Reza Malekzadeh, Leslie Mallinger, Sivabalan Manivannan, Wagner Marcenes, Lyn March, David J. Margolis, Guy B. Marks, Robin Marks, Akira Matsumori, Richard Matzopoulos, Bongani M. Mayosi, John H. McAnulty, Mary M. McDermott, Neil McGill, John McGrath, Maria Elena Medina-Mora, Michele Meltzer, Ziad A. Memish, George A. Mensah, Tony R. Merriman, Ana-Claire Meyer, Valeria Miglioli, Matthew Miller, Ted R. Miller, Philip B. Mitchell, Ana Olga Mocumbi, Terrie E. Moffitt, Ali A. Mokdad, Lorenzo Monasta, Marcella Montico, Maziar Moradi-Lakeh, Andrew Moran, Lidia Morawska, Rintaro Mori, Michele E. Murdoch, Michael K. Mwaniki, Kovin Naidoo, M. Nathan Nair, Luigi Naldi, KM Venkat Narayan, Paul K. Nelson, Robert G. Nelson, Michael C. Nevitt, Charles R. Newton, Sandra Nolte, Paul Norman, Rosana Norman, Martin O'Donnell, Simon O'Hanlon, Casey Olives, Saad B. Omer, Katrina Ortblad, Richard Osborne, Doruk Ozgediz, Andrew Page, Bishnu Pahari, Jeyaraj Durai Pandian, Andrea Panozo Rivero, Scott B. Patten, Neil Pearce, Rogelio Perez Padilla, Fernando Perez-Ruiz, Norberto Perico, Konrad Pesudovs, David Phillips, Michael R. Phillips, Kelsey Pierce, Sébastien Pion, Guilherme V. Polanczyk, Suzanne Polinder, C. Arden Pope, Svetlana Popova, Esteban Porrini, Farshad Pourmalek, Martin Prince, Rachel L. Pullan, Kapa D. Ramaiah, Dharani Ranganathan, Homie Razavi, Mathilda Regan, Jürgen T. Rehm, David B. Rein, Guiseppe Remuzzi, Kathryn Richardson, Frederick P. Rivara, Thomas Roberts, Carolyn Robinson, Felipe Rodriguez De Leòn, Luca Ronfani, Robin Room, Lisa C. Rosenfeld, Lesley Rushton, Ralph L. Sacco, Sukanta Saha, Uchechukwu Sampson, Lidia Sanchez-Riera, Ella Sanman, David C. Schwebel, James Graham Scott, Maria Segui-Gomez, Saeid Shahraz, Donald S. Shepard, Hwashin Shin, Rupak Shivakoti, Donald Silberberg, David Singh, Gitanjali M. Singh, Jasvinder A. Singh, Jessica Singleton, David A. Sleet, Karen Sliwa, Emma Smith, Jennifer L. Smith, Nicolas JC Stapelberg, Andrew Steer, Timothy Steiner, Wilma A. Stolk, Lars Jacob Stovner, Christopher Sudfeld, Sana Syed, Giorgio Tamburlini, Mohammad Tavakkoli, Hugh R. Taylor, Jennifer A. Taylor, William J. Taylor, Bernadette Thomas, W. Murray Thomson, George D. Thurston, Imad M. Tleyjeh, Marcello Tonelli, Jeffrey A. Towbin, Thomas Truelsen, Miltiadis K. Tsilimbaris, Clotilde Ubeda, Eduardo A. Undurraga, Marieke J. van der Werf, Jim van Os, Monica S. Vavilala, N. Venketasubramanian, Mengru Wang, Wenzhi Wang, Kerrianne Watt, David J. Weatherall, Martin A. Weinstock, Robert Weintraub, Marc G. Weisskopf, Myrna M. Weissman, Richard A. White, Harvey Whiteford, Steven T. Wiersma, James D. Wilkinson, Hywel C. Williams, Sean RM Williams, Emma Witt, Frederick Wolfe, Anthony D. Woolf, Sarah Wulf, Pon-Hsiu Yeh, Anita KM Zaidi, Zhi-Jie Zheng, David Zonies, Alan D. Lopez, Christopher JL Murray 14 December 2012 Diagramme 34 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier "This online publication has been corrected The corrected version first appeared at thelancet.com on February 22, 2012, the second corrected version appeared on August 15, 2014" Gesehen am 20.07.2018 <h2>Summary</h2><h3>Background</h3><p>Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).</p><h3>Methods</h3><p>Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis.</p><h3>Findings</h3><p>Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient −0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa.</p><h3>Interpretation</h3><p>Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.</p><h3>Funding</h3><p>Bill & Melinda Gates Foundation.</p> Jonas, Jost B. 1958- verfasserin (DE-588)1028286732 (DE-627)730536823 (DE-576)37578537X aut Enthalten in The lancet London [u.a.] : Elsevier, 1823 380(2012), 9859, Seite 2163-2196 Online-Ressource (DE-627)270128484 (DE-600)1476593-7 (DE-576)078590159 1474-547X nnns volume:380 year:2012 number:9859 pages:2163-2196 extent:34 Erscheint auch als Druck-Ausgabe Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990 - 2010 2012 (DE-627)1449891292 (DE-576)379891298 http://dx.doi.org/10.1016/S0140-6736(12)61729-2 Verlag Resolving-System Volltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61729-2/abstract Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 380 2012 9859 2163-2196 34 2013 01 DE-16-250 3019144531 00 --%%-- --%%-- --%%-- --%%-- l01 20-07-18 2013 01 DE-16-250 00 s hd2012 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_358 2013 01 DE-16-250 03 s s_34 2013 01 DE-16-250 04 p (DE-627)1445785498 Jonas, Jost B. 2013 01 DE-16-250 04 k (DE-627)1416741186 Universitäts-Augenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_167 |
| allfieldsGer |
10.1016/S0140-6736(12)61729-2 doi (DE-627)1577803825 (DE-576)507803825 (DE-599)BSZ507803825 (OCoLC)1341014101 DE-627 ger DE-627 rda eng Vos, Theo verfasserin (DE-588)1123164436 (DE-627)880000031 (DE-576)48164685X aut Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010 a systematic analysis for the Global Burden of Disease Study 2010 Theo Vos, Abraham D. Flaxman, Mohsen Naghavi, Rafael Lozano, Catherine Michaud, Majid Ezzati, Kenji Shibuya, Joshua A. Salomon, Safa Abdalla, Victor Aboyans, Jerry Abraham, Ilana Ackerman, Rakesh Aggarwal, Stephanie Y. Ahn, Mohammed K. Ali, Mohammad A. AlMazroa, Miriam Alvarado, H. Ross Anderson, Laurie M. Anderson, Kathryn G. Andrews, Charles Atkinson, Larry M. Baddour, Adil N. Bahalim, Suzanne Barker-Collo, Lope H. Barrero, David H. Bartels, Maria-Gloria Basáñez, Amanda Baxter, Michelle L. Bell, Emelia J. Benjamin, Derrick Bennett, Eduardo Bernabé, Kavi Bhalla, Bishal Bhandari, Boris Bikbov, Aref Bin Abdulhak, Gretchen Birbeck, James A. Black, Hannah Blencowe, Jed D. Blore, Fiona Blyth, Ian Bolliger, Audrey Bonaventure, Soufiane Boufous, Rupert Bourne, Michel Boussinesq, Tasanee Braithwaite, Carol Brayne, Lisa Bridgett, Simon Brooker, Peter Brooks, Traolach S. Brugha, Claire Bryan-Hancock, Chiara Bucello, Rachelle Buchbinder, Geoffrey Buckle, Christine M. Budke, Michael Burch, Peter Burney, Roy Burstein, Bianca Calabria, Benjamin Campbell, Charles E. Canter, Hélène Carabin, Jonathan Carapetis, Loreto Carmona, Claudia Cella, Fiona Charlson, Honglei Chen, Andrew Tai-Ann Cheng, David Chou, Sumeet S. Chugh, Luc E. Coffeng, Steven D. Colan, Samantha Colquhoun, K. Ellicott Colson, John Condon, Myles D. Connor, Leslie T. Cooper, Matthew Corriere, Monica Cortinovis, Karen Courville de Vaccaro, William Couser, Benjamin C. Cowie, Michael H. Criqui, Marita Cross, Kaustubh C. Dabhadkar, Manu Dahiya, Nabila Dahodwala, James Damsere-Derry, Goodarz Danaei, Adrian Davis, Diego De Leo, Louisa Degenhardt, Robert Dellavalle, Allyne Delossantos, Julie Denenberg, Sarah Derrett, Don C. Des Jarlais, Samath D. Dharmaratne, Mukesh Dherani, Cesar Diaz-Torne, Helen Dolk, E. Ray Dorsey, Tim Driscoll, Herbert Duber, Beth Ebel, Karen Edmond, Alexis Elbaz, Suad Eltahir Ali, Holly Erskine, Patricia J. Erwin, Patricia Espindola, Stalin E. Ewoigbokhan, Farshad Farzadfar, Valery Feigin, David T. Felson, Alize Ferrari, Cleusa P. Ferri, Eric M. Fèvre, Mariel M. Finucane, Seth Flaxman, Louise Flood, Kyle Foreman, Mohammad H. Forouzanfar, Francis Gerry R. Fowkes, Richard Franklin, Marlene Fransen, Michael K. Freeman, Belinda J. Gabbe, Sherine E. Gabriel, Emmanuela Gakidou, Hammad A. Ganatra, Bianca Garcia, Flavio Gaspari, Richard F. Gillum, Gerhard Gmel, Richard Gosselin, Rebecca Grainger, Justina Groeger, Francis Guillemin, David Gunnell, Ramyani Gupta, Juanita Haagsma, Holly Hagan, Yara A. Halasa, Wayne Hall, Diana Haring, Josep Maria Haro, James E. Harrison, Rasmus Havmoeller, Roderick J. Hay, Hideki Higashi, Catherine Hill, Bruno Hoen, Howard Hoffman, Peter J. Hotez, Damian Hoy, John J. Huang, Sydney E. Ibeanusi, Kathryn H. Jacobsen, Spencer L. James, Deborah Jarvis, Rashmi Jasrasaria, Sudha Jayaraman, Nicole Johns, Jost B. Jonas, Ganesan Karthikeyan, Nicholas Kassebaum, Norito Kawakami, Andre Keren, Jon-Paul Khoo, Charles H. King, Lisa Marie Knowlton, Olive Kobusingye, Adofo Koranteng, Rita Krishnamurthi, Ratilal Lalloo, Laura L. Laslett, Tim Lathlean, Janet L. Leasher, Yong Yi Lee, James Leigh, Stephen S. Lim, Elizabeth Limb, John Kent Lin, Michael Lipnick, Steven E. Lipshultz, Wei Liu, Maria Loane, Summer Lockett Ohno, Ronan Lyons, Jixiang Ma, Jacqueline Mabweijano, Michael F. MacIntyre, Reza Malekzadeh, Leslie Mallinger, Sivabalan Manivannan, Wagner Marcenes, Lyn March, David J. Margolis, Guy B. Marks, Robin Marks, Akira Matsumori, Richard Matzopoulos, Bongani M. Mayosi, John H. McAnulty, Mary M. McDermott, Neil McGill, John McGrath, Maria Elena Medina-Mora, Michele Meltzer, Ziad A. Memish, George A. Mensah, Tony R. Merriman, Ana-Claire Meyer, Valeria Miglioli, Matthew Miller, Ted R. Miller, Philip B. Mitchell, Ana Olga Mocumbi, Terrie E. Moffitt, Ali A. Mokdad, Lorenzo Monasta, Marcella Montico, Maziar Moradi-Lakeh, Andrew Moran, Lidia Morawska, Rintaro Mori, Michele E. Murdoch, Michael K. Mwaniki, Kovin Naidoo, M. Nathan Nair, Luigi Naldi, KM Venkat Narayan, Paul K. Nelson, Robert G. Nelson, Michael C. Nevitt, Charles R. Newton, Sandra Nolte, Paul Norman, Rosana Norman, Martin O'Donnell, Simon O'Hanlon, Casey Olives, Saad B. Omer, Katrina Ortblad, Richard Osborne, Doruk Ozgediz, Andrew Page, Bishnu Pahari, Jeyaraj Durai Pandian, Andrea Panozo Rivero, Scott B. Patten, Neil Pearce, Rogelio Perez Padilla, Fernando Perez-Ruiz, Norberto Perico, Konrad Pesudovs, David Phillips, Michael R. Phillips, Kelsey Pierce, Sébastien Pion, Guilherme V. Polanczyk, Suzanne Polinder, C. Arden Pope, Svetlana Popova, Esteban Porrini, Farshad Pourmalek, Martin Prince, Rachel L. Pullan, Kapa D. Ramaiah, Dharani Ranganathan, Homie Razavi, Mathilda Regan, Jürgen T. Rehm, David B. Rein, Guiseppe Remuzzi, Kathryn Richardson, Frederick P. Rivara, Thomas Roberts, Carolyn Robinson, Felipe Rodriguez De Leòn, Luca Ronfani, Robin Room, Lisa C. Rosenfeld, Lesley Rushton, Ralph L. Sacco, Sukanta Saha, Uchechukwu Sampson, Lidia Sanchez-Riera, Ella Sanman, David C. Schwebel, James Graham Scott, Maria Segui-Gomez, Saeid Shahraz, Donald S. Shepard, Hwashin Shin, Rupak Shivakoti, Donald Silberberg, David Singh, Gitanjali M. Singh, Jasvinder A. Singh, Jessica Singleton, David A. Sleet, Karen Sliwa, Emma Smith, Jennifer L. Smith, Nicolas JC Stapelberg, Andrew Steer, Timothy Steiner, Wilma A. Stolk, Lars Jacob Stovner, Christopher Sudfeld, Sana Syed, Giorgio Tamburlini, Mohammad Tavakkoli, Hugh R. Taylor, Jennifer A. Taylor, William J. Taylor, Bernadette Thomas, W. Murray Thomson, George D. Thurston, Imad M. Tleyjeh, Marcello Tonelli, Jeffrey A. Towbin, Thomas Truelsen, Miltiadis K. Tsilimbaris, Clotilde Ubeda, Eduardo A. Undurraga, Marieke J. van der Werf, Jim van Os, Monica S. Vavilala, N. Venketasubramanian, Mengru Wang, Wenzhi Wang, Kerrianne Watt, David J. Weatherall, Martin A. Weinstock, Robert Weintraub, Marc G. Weisskopf, Myrna M. Weissman, Richard A. White, Harvey Whiteford, Steven T. Wiersma, James D. Wilkinson, Hywel C. Williams, Sean RM Williams, Emma Witt, Frederick Wolfe, Anthony D. Woolf, Sarah Wulf, Pon-Hsiu Yeh, Anita KM Zaidi, Zhi-Jie Zheng, David Zonies, Alan D. Lopez, Christopher JL Murray 14 December 2012 Diagramme 34 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier "This online publication has been corrected The corrected version first appeared at thelancet.com on February 22, 2012, the second corrected version appeared on August 15, 2014" Gesehen am 20.07.2018 <h2>Summary</h2><h3>Background</h3><p>Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).</p><h3>Methods</h3><p>Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis.</p><h3>Findings</h3><p>Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient −0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa.</p><h3>Interpretation</h3><p>Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.</p><h3>Funding</h3><p>Bill & Melinda Gates Foundation.</p> Jonas, Jost B. 1958- verfasserin (DE-588)1028286732 (DE-627)730536823 (DE-576)37578537X aut Enthalten in The lancet London [u.a.] : Elsevier, 1823 380(2012), 9859, Seite 2163-2196 Online-Ressource (DE-627)270128484 (DE-600)1476593-7 (DE-576)078590159 1474-547X nnns volume:380 year:2012 number:9859 pages:2163-2196 extent:34 Erscheint auch als Druck-Ausgabe Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990 - 2010 2012 (DE-627)1449891292 (DE-576)379891298 http://dx.doi.org/10.1016/S0140-6736(12)61729-2 Verlag Resolving-System Volltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61729-2/abstract Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 380 2012 9859 2163-2196 34 2013 01 DE-16-250 3019144531 00 --%%-- --%%-- --%%-- --%%-- l01 20-07-18 2013 01 DE-16-250 00 s hd2012 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_358 2013 01 DE-16-250 03 s s_34 2013 01 DE-16-250 04 p (DE-627)1445785498 Jonas, Jost B. 2013 01 DE-16-250 04 k (DE-627)1416741186 Universitäts-Augenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_167 |
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10.1016/S0140-6736(12)61729-2 doi (DE-627)1577803825 (DE-576)507803825 (DE-599)BSZ507803825 (OCoLC)1341014101 DE-627 ger DE-627 rda eng Vos, Theo verfasserin (DE-588)1123164436 (DE-627)880000031 (DE-576)48164685X aut Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010 a systematic analysis for the Global Burden of Disease Study 2010 Theo Vos, Abraham D. Flaxman, Mohsen Naghavi, Rafael Lozano, Catherine Michaud, Majid Ezzati, Kenji Shibuya, Joshua A. Salomon, Safa Abdalla, Victor Aboyans, Jerry Abraham, Ilana Ackerman, Rakesh Aggarwal, Stephanie Y. Ahn, Mohammed K. Ali, Mohammad A. AlMazroa, Miriam Alvarado, H. Ross Anderson, Laurie M. Anderson, Kathryn G. Andrews, Charles Atkinson, Larry M. Baddour, Adil N. Bahalim, Suzanne Barker-Collo, Lope H. Barrero, David H. Bartels, Maria-Gloria Basáñez, Amanda Baxter, Michelle L. Bell, Emelia J. Benjamin, Derrick Bennett, Eduardo Bernabé, Kavi Bhalla, Bishal Bhandari, Boris Bikbov, Aref Bin Abdulhak, Gretchen Birbeck, James A. Black, Hannah Blencowe, Jed D. Blore, Fiona Blyth, Ian Bolliger, Audrey Bonaventure, Soufiane Boufous, Rupert Bourne, Michel Boussinesq, Tasanee Braithwaite, Carol Brayne, Lisa Bridgett, Simon Brooker, Peter Brooks, Traolach S. Brugha, Claire Bryan-Hancock, Chiara Bucello, Rachelle Buchbinder, Geoffrey Buckle, Christine M. Budke, Michael Burch, Peter Burney, Roy Burstein, Bianca Calabria, Benjamin Campbell, Charles E. Canter, Hélène Carabin, Jonathan Carapetis, Loreto Carmona, Claudia Cella, Fiona Charlson, Honglei Chen, Andrew Tai-Ann Cheng, David Chou, Sumeet S. Chugh, Luc E. Coffeng, Steven D. Colan, Samantha Colquhoun, K. Ellicott Colson, John Condon, Myles D. Connor, Leslie T. Cooper, Matthew Corriere, Monica Cortinovis, Karen Courville de Vaccaro, William Couser, Benjamin C. Cowie, Michael H. Criqui, Marita Cross, Kaustubh C. Dabhadkar, Manu Dahiya, Nabila Dahodwala, James Damsere-Derry, Goodarz Danaei, Adrian Davis, Diego De Leo, Louisa Degenhardt, Robert Dellavalle, Allyne Delossantos, Julie Denenberg, Sarah Derrett, Don C. Des Jarlais, Samath D. Dharmaratne, Mukesh Dherani, Cesar Diaz-Torne, Helen Dolk, E. Ray Dorsey, Tim Driscoll, Herbert Duber, Beth Ebel, Karen Edmond, Alexis Elbaz, Suad Eltahir Ali, Holly Erskine, Patricia J. Erwin, Patricia Espindola, Stalin E. Ewoigbokhan, Farshad Farzadfar, Valery Feigin, David T. Felson, Alize Ferrari, Cleusa P. Ferri, Eric M. Fèvre, Mariel M. Finucane, Seth Flaxman, Louise Flood, Kyle Foreman, Mohammad H. Forouzanfar, Francis Gerry R. Fowkes, Richard Franklin, Marlene Fransen, Michael K. Freeman, Belinda J. Gabbe, Sherine E. Gabriel, Emmanuela Gakidou, Hammad A. Ganatra, Bianca Garcia, Flavio Gaspari, Richard F. Gillum, Gerhard Gmel, Richard Gosselin, Rebecca Grainger, Justina Groeger, Francis Guillemin, David Gunnell, Ramyani Gupta, Juanita Haagsma, Holly Hagan, Yara A. Halasa, Wayne Hall, Diana Haring, Josep Maria Haro, James E. Harrison, Rasmus Havmoeller, Roderick J. Hay, Hideki Higashi, Catherine Hill, Bruno Hoen, Howard Hoffman, Peter J. Hotez, Damian Hoy, John J. Huang, Sydney E. Ibeanusi, Kathryn H. Jacobsen, Spencer L. James, Deborah Jarvis, Rashmi Jasrasaria, Sudha Jayaraman, Nicole Johns, Jost B. Jonas, Ganesan Karthikeyan, Nicholas Kassebaum, Norito Kawakami, Andre Keren, Jon-Paul Khoo, Charles H. King, Lisa Marie Knowlton, Olive Kobusingye, Adofo Koranteng, Rita Krishnamurthi, Ratilal Lalloo, Laura L. Laslett, Tim Lathlean, Janet L. Leasher, Yong Yi Lee, James Leigh, Stephen S. Lim, Elizabeth Limb, John Kent Lin, Michael Lipnick, Steven E. Lipshultz, Wei Liu, Maria Loane, Summer Lockett Ohno, Ronan Lyons, Jixiang Ma, Jacqueline Mabweijano, Michael F. MacIntyre, Reza Malekzadeh, Leslie Mallinger, Sivabalan Manivannan, Wagner Marcenes, Lyn March, David J. Margolis, Guy B. Marks, Robin Marks, Akira Matsumori, Richard Matzopoulos, Bongani M. Mayosi, John H. McAnulty, Mary M. McDermott, Neil McGill, John McGrath, Maria Elena Medina-Mora, Michele Meltzer, Ziad A. Memish, George A. Mensah, Tony R. Merriman, Ana-Claire Meyer, Valeria Miglioli, Matthew Miller, Ted R. Miller, Philip B. Mitchell, Ana Olga Mocumbi, Terrie E. Moffitt, Ali A. Mokdad, Lorenzo Monasta, Marcella Montico, Maziar Moradi-Lakeh, Andrew Moran, Lidia Morawska, Rintaro Mori, Michele E. Murdoch, Michael K. Mwaniki, Kovin Naidoo, M. Nathan Nair, Luigi Naldi, KM Venkat Narayan, Paul K. Nelson, Robert G. Nelson, Michael C. Nevitt, Charles R. Newton, Sandra Nolte, Paul Norman, Rosana Norman, Martin O'Donnell, Simon O'Hanlon, Casey Olives, Saad B. Omer, Katrina Ortblad, Richard Osborne, Doruk Ozgediz, Andrew Page, Bishnu Pahari, Jeyaraj Durai Pandian, Andrea Panozo Rivero, Scott B. Patten, Neil Pearce, Rogelio Perez Padilla, Fernando Perez-Ruiz, Norberto Perico, Konrad Pesudovs, David Phillips, Michael R. Phillips, Kelsey Pierce, Sébastien Pion, Guilherme V. Polanczyk, Suzanne Polinder, C. Arden Pope, Svetlana Popova, Esteban Porrini, Farshad Pourmalek, Martin Prince, Rachel L. Pullan, Kapa D. Ramaiah, Dharani Ranganathan, Homie Razavi, Mathilda Regan, Jürgen T. Rehm, David B. Rein, Guiseppe Remuzzi, Kathryn Richardson, Frederick P. Rivara, Thomas Roberts, Carolyn Robinson, Felipe Rodriguez De Leòn, Luca Ronfani, Robin Room, Lisa C. Rosenfeld, Lesley Rushton, Ralph L. Sacco, Sukanta Saha, Uchechukwu Sampson, Lidia Sanchez-Riera, Ella Sanman, David C. Schwebel, James Graham Scott, Maria Segui-Gomez, Saeid Shahraz, Donald S. Shepard, Hwashin Shin, Rupak Shivakoti, Donald Silberberg, David Singh, Gitanjali M. Singh, Jasvinder A. Singh, Jessica Singleton, David A. Sleet, Karen Sliwa, Emma Smith, Jennifer L. Smith, Nicolas JC Stapelberg, Andrew Steer, Timothy Steiner, Wilma A. Stolk, Lars Jacob Stovner, Christopher Sudfeld, Sana Syed, Giorgio Tamburlini, Mohammad Tavakkoli, Hugh R. Taylor, Jennifer A. Taylor, William J. Taylor, Bernadette Thomas, W. Murray Thomson, George D. Thurston, Imad M. Tleyjeh, Marcello Tonelli, Jeffrey A. Towbin, Thomas Truelsen, Miltiadis K. Tsilimbaris, Clotilde Ubeda, Eduardo A. Undurraga, Marieke J. van der Werf, Jim van Os, Monica S. Vavilala, N. Venketasubramanian, Mengru Wang, Wenzhi Wang, Kerrianne Watt, David J. Weatherall, Martin A. Weinstock, Robert Weintraub, Marc G. Weisskopf, Myrna M. Weissman, Richard A. White, Harvey Whiteford, Steven T. Wiersma, James D. Wilkinson, Hywel C. Williams, Sean RM Williams, Emma Witt, Frederick Wolfe, Anthony D. Woolf, Sarah Wulf, Pon-Hsiu Yeh, Anita KM Zaidi, Zhi-Jie Zheng, David Zonies, Alan D. Lopez, Christopher JL Murray 14 December 2012 Diagramme 34 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier "This online publication has been corrected The corrected version first appeared at thelancet.com on February 22, 2012, the second corrected version appeared on August 15, 2014" Gesehen am 20.07.2018 <h2>Summary</h2><h3>Background</h3><p>Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).</p><h3>Methods</h3><p>Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis.</p><h3>Findings</h3><p>Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient −0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa.</p><h3>Interpretation</h3><p>Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.</p><h3>Funding</h3><p>Bill & Melinda Gates Foundation.</p> Jonas, Jost B. 1958- verfasserin (DE-588)1028286732 (DE-627)730536823 (DE-576)37578537X aut Enthalten in The lancet London [u.a.] : Elsevier, 1823 380(2012), 9859, Seite 2163-2196 Online-Ressource (DE-627)270128484 (DE-600)1476593-7 (DE-576)078590159 1474-547X nnns volume:380 year:2012 number:9859 pages:2163-2196 extent:34 Erscheint auch als Druck-Ausgabe Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990 - 2010 2012 (DE-627)1449891292 (DE-576)379891298 http://dx.doi.org/10.1016/S0140-6736(12)61729-2 Verlag Resolving-System Volltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61729-2/abstract Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 380 2012 9859 2163-2196 34 2013 01 DE-16-250 3019144531 00 --%%-- --%%-- --%%-- --%%-- l01 20-07-18 2013 01 DE-16-250 00 s hd2012 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_358 2013 01 DE-16-250 03 s s_34 2013 01 DE-16-250 04 p (DE-627)1445785498 Jonas, Jost B. 2013 01 DE-16-250 04 k (DE-627)1416741186 Universitäts-Augenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_167 |
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Flaxman, Mohsen Naghavi, Rafael Lozano, Catherine Michaud, Majid Ezzati, Kenji Shibuya, Joshua A. Salomon, Safa Abdalla, Victor Aboyans, Jerry Abraham, Ilana Ackerman, Rakesh Aggarwal, Stephanie Y. Ahn, Mohammed K. Ali, Mohammad A. AlMazroa, Miriam Alvarado, H. Ross Anderson, Laurie M. Anderson, Kathryn G. Andrews, Charles Atkinson, Larry M. Baddour, Adil N. Bahalim, Suzanne Barker-Collo, Lope H. Barrero, David H. Bartels, Maria-Gloria Basáñez, Amanda Baxter, Michelle L. Bell, Emelia J. Benjamin, Derrick Bennett, Eduardo Bernabé, Kavi Bhalla, Bishal Bhandari, Boris Bikbov, Aref Bin Abdulhak, Gretchen Birbeck, James A. Black, Hannah Blencowe, Jed D. Blore, Fiona Blyth, Ian Bolliger, Audrey Bonaventure, Soufiane Boufous, Rupert Bourne, Michel Boussinesq, Tasanee Braithwaite, Carol Brayne, Lisa Bridgett, Simon Brooker, Peter Brooks, Traolach S. Brugha, Claire Bryan-Hancock, Chiara Bucello, Rachelle Buchbinder, Geoffrey Buckle, Christine M. Budke, Michael Burch, Peter Burney, Roy Burstein, Bianca Calabria, Benjamin Campbell, Charles E. Canter, Hélène Carabin, Jonathan Carapetis, Loreto Carmona, Claudia Cella, Fiona Charlson, Honglei Chen, Andrew Tai-Ann Cheng, David Chou, Sumeet S. Chugh, Luc E. Coffeng, Steven D. Colan, Samantha Colquhoun, K. Ellicott Colson, John Condon, Myles D. Connor, Leslie T. Cooper, Matthew Corriere, Monica Cortinovis, Karen Courville de Vaccaro, William Couser, Benjamin C. Cowie, Michael H. Criqui, Marita Cross, Kaustubh C. Dabhadkar, Manu Dahiya, Nabila Dahodwala, James Damsere-Derry, Goodarz Danaei, Adrian Davis, Diego De Leo, Louisa Degenhardt, Robert Dellavalle, Allyne Delossantos, Julie Denenberg, Sarah Derrett, Don C. Des Jarlais, Samath D. Dharmaratne, Mukesh Dherani, Cesar Diaz-Torne, Helen Dolk, E. Ray Dorsey, Tim Driscoll, Herbert Duber, Beth Ebel, Karen Edmond, Alexis Elbaz, Suad Eltahir Ali, Holly Erskine, Patricia J. Erwin, Patricia Espindola, Stalin E. Ewoigbokhan, Farshad Farzadfar, Valery Feigin, David T. Felson, Alize Ferrari, Cleusa P. Ferri, Eric M. Fèvre, Mariel M. Finucane, Seth Flaxman, Louise Flood, Kyle Foreman, Mohammad H. Forouzanfar, Francis Gerry R. Fowkes, Richard Franklin, Marlene Fransen, Michael K. Freeman, Belinda J. Gabbe, Sherine E. Gabriel, Emmanuela Gakidou, Hammad A. Ganatra, Bianca Garcia, Flavio Gaspari, Richard F. Gillum, Gerhard Gmel, Richard Gosselin, Rebecca Grainger, Justina Groeger, Francis Guillemin, David Gunnell, Ramyani Gupta, Juanita Haagsma, Holly Hagan, Yara A. Halasa, Wayne Hall, Diana Haring, Josep Maria Haro, James E. Harrison, Rasmus Havmoeller, Roderick J. Hay, Hideki Higashi, Catherine Hill, Bruno Hoen, Howard Hoffman, Peter J. Hotez, Damian Hoy, John J. Huang, Sydney E. Ibeanusi, Kathryn H. Jacobsen, Spencer L. James, Deborah Jarvis, Rashmi Jasrasaria, Sudha Jayaraman, Nicole Johns, Jost B. Jonas, Ganesan Karthikeyan, Nicholas Kassebaum, Norito Kawakami, Andre Keren, Jon-Paul Khoo, Charles H. King, Lisa Marie Knowlton, Olive Kobusingye, Adofo Koranteng, Rita Krishnamurthi, Ratilal Lalloo, Laura L. Laslett, Tim Lathlean, Janet L. Leasher, Yong Yi Lee, James Leigh, Stephen S. Lim, Elizabeth Limb, John Kent Lin, Michael Lipnick, Steven E. Lipshultz, Wei Liu, Maria Loane, Summer Lockett Ohno, Ronan Lyons, Jixiang Ma, Jacqueline Mabweijano, Michael F. MacIntyre, Reza Malekzadeh, Leslie Mallinger, Sivabalan Manivannan, Wagner Marcenes, Lyn March, David J. Margolis, Guy B. Marks, Robin Marks, Akira Matsumori, Richard Matzopoulos, Bongani M. Mayosi, John H. McAnulty, Mary M. McDermott, Neil McGill, John McGrath, Maria Elena Medina-Mora, Michele Meltzer, Ziad A. Memish, George A. Mensah, Tony R. Merriman, Ana-Claire Meyer, Valeria Miglioli, Matthew Miller, Ted R. Miller, Philip B. Mitchell, Ana Olga Mocumbi, Terrie E. Moffitt, Ali A. Mokdad, Lorenzo Monasta, Marcella Montico, Maziar Moradi-Lakeh, Andrew Moran, Lidia Morawska, Rintaro Mori, Michele E. Murdoch, Michael K. Mwaniki, Kovin Naidoo, M. Nathan Nair, Luigi Naldi, KM Venkat Narayan, Paul K. Nelson, Robert G. Nelson, Michael C. Nevitt, Charles R. Newton, Sandra Nolte, Paul Norman, Rosana Norman, Martin O'Donnell, Simon O'Hanlon, Casey Olives, Saad B. Omer, Katrina Ortblad, Richard Osborne, Doruk Ozgediz, Andrew Page, Bishnu Pahari, Jeyaraj Durai Pandian, Andrea Panozo Rivero, Scott B. Patten, Neil Pearce, Rogelio Perez Padilla, Fernando Perez-Ruiz, Norberto Perico, Konrad Pesudovs, David Phillips, Michael R. Phillips, Kelsey Pierce, Sébastien Pion, Guilherme V. Polanczyk, Suzanne Polinder, C. Arden Pope, Svetlana Popova, Esteban Porrini, Farshad Pourmalek, Martin Prince, Rachel L. Pullan, Kapa D. Ramaiah, Dharani Ranganathan, Homie Razavi, Mathilda Regan, Jürgen T. Rehm, David B. Rein, Guiseppe Remuzzi, Kathryn Richardson, Frederick P. Rivara, Thomas Roberts, Carolyn Robinson, Felipe Rodriguez De Leòn, Luca Ronfani, Robin Room, Lisa C. Rosenfeld, Lesley Rushton, Ralph L. Sacco, Sukanta Saha, Uchechukwu Sampson, Lidia Sanchez-Riera, Ella Sanman, David C. Schwebel, James Graham Scott, Maria Segui-Gomez, Saeid Shahraz, Donald S. Shepard, Hwashin Shin, Rupak Shivakoti, Donald Silberberg, David Singh, Gitanjali M. Singh, Jasvinder A. Singh, Jessica Singleton, David A. Sleet, Karen Sliwa, Emma Smith, Jennifer L. Smith, Nicolas JC Stapelberg, Andrew Steer, Timothy Steiner, Wilma A. Stolk, Lars Jacob Stovner, Christopher Sudfeld, Sana Syed, Giorgio Tamburlini, Mohammad Tavakkoli, Hugh R. Taylor, Jennifer A. Taylor, William J. Taylor, Bernadette Thomas, W. Murray Thomson, George D. Thurston, Imad M. Tleyjeh, Marcello Tonelli, Jeffrey A. Towbin, Thomas Truelsen, Miltiadis K. Tsilimbaris, Clotilde Ubeda, Eduardo A. Undurraga, Marieke J. van der Werf, Jim van Os, Monica S. Vavilala, N. Venketasubramanian, Mengru Wang, Wenzhi Wang, Kerrianne Watt, David J. Weatherall, Martin A. Weinstock, Robert Weintraub, Marc G. Weisskopf, Myrna M. Weissman, Richard A. White, Harvey Whiteford, Steven T. Wiersma, James D. Wilkinson, Hywel C. Williams, Sean RM Williams, Emma Witt, Frederick Wolfe, Anthony D. Woolf, Sarah Wulf, Pon-Hsiu Yeh, Anita KM Zaidi, Zhi-Jie Zheng, David Zonies, Alan D. Lopez, Christopher JL Murray</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">14 December 2012</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="b">Diagramme</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">34</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">"This online publication has been corrected</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">The corrected version first appeared at thelancet.com on February 22, 2012, the second corrected version appeared on August 15, 2014"</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Gesehen am 20.07.2018</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a"><h2>Summary</h2><h3>Background</h3><p>Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).</p><h3>Methods</h3><p>Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis.</p><h3>Findings</h3><p>Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient −0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa.</p><h3>Interpretation</h3><p>Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.</p><h3>Funding</h3><p>Bill & Melinda Gates Foundation.</p></subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jonas, Jost B.</subfield><subfield code="d">1958-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)1028286732</subfield><subfield code="0">(DE-627)730536823</subfield><subfield code="0">(DE-576)37578537X</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">The lancet</subfield><subfield code="d">London [u.a.] : Elsevier, 1823</subfield><subfield code="g">380(2012), 9859, Seite 2163-2196</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)270128484</subfield><subfield code="w">(DE-600)1476593-7</subfield><subfield code="w">(DE-576)078590159</subfield><subfield code="x">1474-547X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:380</subfield><subfield code="g">year:2012</subfield><subfield code="g">number:9859</subfield><subfield code="g">pages:2163-2196</subfield><subfield code="g">extent:34</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="t">Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990 - 2010</subfield><subfield code="d">2012</subfield><subfield code="w">(DE-627)1449891292</subfield><subfield code="w">(DE-576)379891298</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1016/S0140-6736(12)61729-2</subfield><subfield code="x">Verlag</subfield><subfield code="x">Resolving-System</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61729-2/abstract</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2013</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ISIL_DE-16-250</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_1</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_KXP</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield 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Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010 a systematic analysis for the Global Burden of Disease Study 2010 Theo Vos, Abraham D. Flaxman, Mohsen Naghavi, Rafael Lozano, Catherine Michaud, Majid Ezzati, Kenji Shibuya, Joshua A. Salomon, Safa Abdalla, Victor Aboyans, Jerry Abraham, Ilana Ackerman, Rakesh Aggarwal, Stephanie Y. Ahn, Mohammed K. Ali, Mohammad A. AlMazroa, Miriam Alvarado, H. Ross Anderson, Laurie M. Anderson, Kathryn G. Andrews, Charles Atkinson, Larry M. Baddour, Adil N. Bahalim, Suzanne Barker-Collo, Lope H. Barrero, David H. Bartels, Maria-Gloria Basáñez, Amanda Baxter, Michelle L. Bell, Emelia J. Benjamin, Derrick Bennett, Eduardo Bernabé, Kavi Bhalla, Bishal Bhandari, Boris Bikbov, Aref Bin Abdulhak, Gretchen Birbeck, James A. Black, Hannah Blencowe, Jed D. Blore, Fiona Blyth, Ian Bolliger, Audrey Bonaventure, Soufiane Boufous, Rupert Bourne, Michel Boussinesq, Tasanee Braithwaite, Carol Brayne, Lisa Bridgett, Simon Brooker, Peter Brooks, Traolach S. Brugha, Claire Bryan-Hancock, Chiara Bucello, Rachelle Buchbinder, Geoffrey Buckle, Christine M. Budke, Michael Burch, Peter Burney, Roy Burstein, Bianca Calabria, Benjamin Campbell, Charles E. Canter, Hélène Carabin, Jonathan Carapetis, Loreto Carmona, Claudia Cella, Fiona Charlson, Honglei Chen, Andrew Tai-Ann Cheng, David Chou, Sumeet S. Chugh, Luc E. Coffeng, Steven D. Colan, Samantha Colquhoun, K. Ellicott Colson, John Condon, Myles D. Connor, Leslie T. Cooper, Matthew Corriere, Monica Cortinovis, Karen Courville de Vaccaro, William Couser, Benjamin C. Cowie, Michael H. Criqui, Marita Cross, Kaustubh C. Dabhadkar, Manu Dahiya, Nabila Dahodwala, James Damsere-Derry, Goodarz Danaei, Adrian Davis, Diego De Leo, Louisa Degenhardt, Robert Dellavalle, Allyne Delossantos, Julie Denenberg, Sarah Derrett, Don C. Des Jarlais, Samath D. Dharmaratne, Mukesh Dherani, Cesar Diaz-Torne, Helen Dolk, E. Ray Dorsey, Tim Driscoll, Herbert Duber, Beth Ebel, Karen Edmond, Alexis Elbaz, Suad Eltahir Ali, Holly Erskine, Patricia J. Erwin, Patricia Espindola, Stalin E. Ewoigbokhan, Farshad Farzadfar, Valery Feigin, David T. Felson, Alize Ferrari, Cleusa P. Ferri, Eric M. Fèvre, Mariel M. Finucane, Seth Flaxman, Louise Flood, Kyle Foreman, Mohammad H. Forouzanfar, Francis Gerry R. Fowkes, Richard Franklin, Marlene Fransen, Michael K. Freeman, Belinda J. Gabbe, Sherine E. Gabriel, Emmanuela Gakidou, Hammad A. Ganatra, Bianca Garcia, Flavio Gaspari, Richard F. Gillum, Gerhard Gmel, Richard Gosselin, Rebecca Grainger, Justina Groeger, Francis Guillemin, David Gunnell, Ramyani Gupta, Juanita Haagsma, Holly Hagan, Yara A. Halasa, Wayne Hall, Diana Haring, Josep Maria Haro, James E. Harrison, Rasmus Havmoeller, Roderick J. Hay, Hideki Higashi, Catherine Hill, Bruno Hoen, Howard Hoffman, Peter J. Hotez, Damian Hoy, John J. Huang, Sydney E. Ibeanusi, Kathryn H. Jacobsen, Spencer L. James, Deborah Jarvis, Rashmi Jasrasaria, Sudha Jayaraman, Nicole Johns, Jost B. Jonas, Ganesan Karthikeyan, Nicholas Kassebaum, Norito Kawakami, Andre Keren, Jon-Paul Khoo, Charles H. King, Lisa Marie Knowlton, Olive Kobusingye, Adofo Koranteng, Rita Krishnamurthi, Ratilal Lalloo, Laura L. Laslett, Tim Lathlean, Janet L. Leasher, Yong Yi Lee, James Leigh, Stephen S. Lim, Elizabeth Limb, John Kent Lin, Michael Lipnick, Steven E. Lipshultz, Wei Liu, Maria Loane, Summer Lockett Ohno, Ronan Lyons, Jixiang Ma, Jacqueline Mabweijano, Michael F. MacIntyre, Reza Malekzadeh, Leslie Mallinger, Sivabalan Manivannan, Wagner Marcenes, Lyn March, David J. Margolis, Guy B. Marks, Robin Marks, Akira Matsumori, Richard Matzopoulos, Bongani M. Mayosi, John H. McAnulty, Mary M. McDermott, Neil McGill, John McGrath, Maria Elena Medina-Mora, Michele Meltzer, Ziad A. Memish, George A. Mensah, Tony R. Merriman, Ana-Claire Meyer, Valeria Miglioli, Matthew Miller, Ted R. Miller, Philip B. Mitchell, Ana Olga Mocumbi, Terrie E. Moffitt, Ali A. Mokdad, Lorenzo Monasta, Marcella Montico, Maziar Moradi-Lakeh, Andrew Moran, Lidia Morawska, Rintaro Mori, Michele E. Murdoch, Michael K. Mwaniki, Kovin Naidoo, M. Nathan Nair, Luigi Naldi, KM Venkat Narayan, Paul K. Nelson, Robert G. Nelson, Michael C. Nevitt, Charles R. Newton, Sandra Nolte, Paul Norman, Rosana Norman, Martin O'Donnell, Simon O'Hanlon, Casey Olives, Saad B. 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a systematic analysis for the Global Burden of Disease Study 2010 |
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years lived with disability (ylds) for 1160 sequelae of 289 diseases and injuries 1990-2010a systematic analysis for the global burden of disease study 2010 |
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Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010 a systematic analysis for the Global Burden of Disease Study 2010 |
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<h2>Summary</h2><h3>Background</h3><p>Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).</p><h3>Methods</h3><p>Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis.</p><h3>Findings</h3><p>Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient −0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa.</p><h3>Interpretation</h3><p>Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.</p><h3>Funding</h3><p>Bill & Melinda Gates Foundation.</p> "This online publication has been corrected The corrected version first appeared at thelancet.com on February 22, 2012, the second corrected version appeared on August 15, 2014" Gesehen am 20.07.2018 |
| abstractGer |
<h2>Summary</h2><h3>Background</h3><p>Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).</p><h3>Methods</h3><p>Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis.</p><h3>Findings</h3><p>Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient −0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa.</p><h3>Interpretation</h3><p>Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.</p><h3>Funding</h3><p>Bill & Melinda Gates Foundation.</p> "This online publication has been corrected The corrected version first appeared at thelancet.com on February 22, 2012, the second corrected version appeared on August 15, 2014" Gesehen am 20.07.2018 |
| abstract_unstemmed |
<h2>Summary</h2><h3>Background</h3><p>Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).</p><h3>Methods</h3><p>Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis.</p><h3>Findings</h3><p>Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient −0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa.</p><h3>Interpretation</h3><p>Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.</p><h3>Funding</h3><p>Bill & Melinda Gates Foundation.</p> "This online publication has been corrected The corrected version first appeared at thelancet.com on February 22, 2012, the second corrected version appeared on August 15, 2014" Gesehen am 20.07.2018 |
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| title_short |
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010 |
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http://dx.doi.org/10.1016/S0140-6736(12)61729-2 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61729-2/abstract |
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Flaxman, Mohsen Naghavi, Rafael Lozano, Catherine Michaud, Majid Ezzati, Kenji Shibuya, Joshua A. Salomon, Safa Abdalla, Victor Aboyans, Jerry Abraham, Ilana Ackerman, Rakesh Aggarwal, Stephanie Y. Ahn, Mohammed K. Ali, Mohammad A. AlMazroa, Miriam Alvarado, H. Ross Anderson, Laurie M. Anderson, Kathryn G. Andrews, Charles Atkinson, Larry M. Baddour, Adil N. Bahalim, Suzanne Barker-Collo, Lope H. Barrero, David H. Bartels, Maria-Gloria Basáñez, Amanda Baxter, Michelle L. Bell, Emelia J. Benjamin, Derrick Bennett, Eduardo Bernabé, Kavi Bhalla, Bishal Bhandari, Boris Bikbov, Aref Bin Abdulhak, Gretchen Birbeck, James A. Black, Hannah Blencowe, Jed D. Blore, Fiona Blyth, Ian Bolliger, Audrey Bonaventure, Soufiane Boufous, Rupert Bourne, Michel Boussinesq, Tasanee Braithwaite, Carol Brayne, Lisa Bridgett, Simon Brooker, Peter Brooks, Traolach S. Brugha, Claire Bryan-Hancock, Chiara Bucello, Rachelle Buchbinder, Geoffrey Buckle, Christine M. Budke, Michael Burch, Peter Burney, Roy Burstein, Bianca Calabria, Benjamin Campbell, Charles E. Canter, Hélène Carabin, Jonathan Carapetis, Loreto Carmona, Claudia Cella, Fiona Charlson, Honglei Chen, Andrew Tai-Ann Cheng, David Chou, Sumeet S. Chugh, Luc E. Coffeng, Steven D. Colan, Samantha Colquhoun, K. Ellicott Colson, John Condon, Myles D. Connor, Leslie T. Cooper, Matthew Corriere, Monica Cortinovis, Karen Courville de Vaccaro, William Couser, Benjamin C. Cowie, Michael H. Criqui, Marita Cross, Kaustubh C. Dabhadkar, Manu Dahiya, Nabila Dahodwala, James Damsere-Derry, Goodarz Danaei, Adrian Davis, Diego De Leo, Louisa Degenhardt, Robert Dellavalle, Allyne Delossantos, Julie Denenberg, Sarah Derrett, Don C. Des Jarlais, Samath D. Dharmaratne, Mukesh Dherani, Cesar Diaz-Torne, Helen Dolk, E. Ray Dorsey, Tim Driscoll, Herbert Duber, Beth Ebel, Karen Edmond, Alexis Elbaz, Suad Eltahir Ali, Holly Erskine, Patricia J. Erwin, Patricia Espindola, Stalin E. Ewoigbokhan, Farshad Farzadfar, Valery Feigin, David T. Felson, Alize Ferrari, Cleusa P. Ferri, Eric M. Fèvre, Mariel M. Finucane, Seth Flaxman, Louise Flood, Kyle Foreman, Mohammad H. Forouzanfar, Francis Gerry R. Fowkes, Richard Franklin, Marlene Fransen, Michael K. Freeman, Belinda J. Gabbe, Sherine E. Gabriel, Emmanuela Gakidou, Hammad A. Ganatra, Bianca Garcia, Flavio Gaspari, Richard F. Gillum, Gerhard Gmel, Richard Gosselin, Rebecca Grainger, Justina Groeger, Francis Guillemin, David Gunnell, Ramyani Gupta, Juanita Haagsma, Holly Hagan, Yara A. Halasa, Wayne Hall, Diana Haring, Josep Maria Haro, James E. Harrison, Rasmus Havmoeller, Roderick J. Hay, Hideki Higashi, Catherine Hill, Bruno Hoen, Howard Hoffman, Peter J. Hotez, Damian Hoy, John J. Huang, Sydney E. Ibeanusi, Kathryn H. Jacobsen, Spencer L. James, Deborah Jarvis, Rashmi Jasrasaria, Sudha Jayaraman, Nicole Johns, Jost B. 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Lopez, Christopher JL Murray</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">14 December 2012</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="b">Diagramme</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">34</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">"This online publication has been corrected</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">The corrected version first appeared at thelancet.com on February 22, 2012, the second corrected version appeared on August 15, 2014"</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Gesehen am 20.07.2018</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a"><h2>Summary</h2><h3>Background</h3><p>Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).</p><h3>Methods</h3><p>Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis.</p><h3>Findings</h3><p>Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient −0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa.</p><h3>Interpretation</h3><p>Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.</p><h3>Funding</h3><p>Bill & Melinda Gates Foundation.</p></subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jonas, Jost B.</subfield><subfield code="d">1958-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)1028286732</subfield><subfield code="0">(DE-627)730536823</subfield><subfield code="0">(DE-576)37578537X</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">The lancet</subfield><subfield code="d">London [u.a.] : Elsevier, 1823</subfield><subfield code="g">380(2012), 9859, Seite 2163-2196</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)270128484</subfield><subfield code="w">(DE-600)1476593-7</subfield><subfield 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