Systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapy : the Polish MOBIT project
Personalized and precision medicine is gaining recognition due to the limitations by standard diagnosis and treatment; many areas of medicine, from cancer to psychiatry, are moving towards tailored and individualized treatment for patients based on their clinical characteristics and genetic signatur...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Nikliński, Jacek - 1963- [verfasserIn] Manegold, Christian - 1946- [verfasserIn] Pilz, Lothar R. - 1954- [verfasserIn] Allgayer, Heike - 1969- [verfasserIn] Abba, Mohammed L. - 1974- [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
21 June 2017 |
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| Schlagwörter: |
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| Anmerkung: |
Gesehen am 27.08.2018 Available online 21 June 2017 |
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| Umfang: |
9 |
| Übergeordnetes Werk: |
Enthalten in: Advances in medical sciences - Amsterdam [u.a.] : Elsevier, 2006, 62(2017), 2, Seite 405-413 |
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| Übergeordnetes Werk: |
volume:62 ; year:2017 ; number:2 ; pages:405-413 ; extent:9 |
| Links: |
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| DOI / URN: |
10.1016/j.advms.2017.05.002 |
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| Katalog-ID: |
1580403034 |
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| 245 | 1 | 0 | |a Systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapy |b the Polish MOBIT project |c Jacek Niklinski, Adam Kretowski, Marcin Moniuszko, Joanna Reszec, Anna Michalska-Falkowska, Magdalena Niemira, Michal Ciborowski, Radoslaw Charkiewicz, Dorota Jurgilewicz, Miroslaw Kozlowski, Rodryg Ramlau, Cezary Piwkowski, Miroslaw Kwasniewski, Monika Kaczmarek, Andrzej Ciereszko, Tomasz Wasniewski, Robert Mroz, Wojciech Naumnik, Ewa Sierko, Magdalena Paczkowska, Joanna Kisluk, Anetta Sulewska, Adam Cybulski, Zenon Mariak, Boguslaw Kedra, Jacek Szamatowicz, Paweł Kurzawa, Lukasz Minarowski, Angelika Edyta Charkiewicz, Barbara Mroczko, Jolanta Malyszko, Christian Manegold, Lothar Pilz, Heike Allgayer, Mohammed L. Abba, Hartmut Juhl, Frauke Koch, the MOBIT Study Group |
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| 520 | |a Personalized and precision medicine is gaining recognition due to the limitations by standard diagnosis and treatment; many areas of medicine, from cancer to psychiatry, are moving towards tailored and individualized treatment for patients based on their clinical characteristics and genetic signatures as well as novel imaging techniques. Advances in whole genome sequencing have led to identification of genes involved in a variety of diseases. Moreover, biomarkers indicating severity of disease or susceptibility to treatment are increasingly being characterized. The continued identification of new genes and biomarkers specific to disease subtypes and individual patients is essential and inevitable for translation into personalized medicine, in estimating both, disease risk and response to therapy. Taking into consideration the mostly unsolved necessity of tailored therapy in oncology the innovative project MOBIT (molecular biomarkers for individualized therapy) was designed. The aims of the project are: (i) establishing integrative management of precise tumor diagnosis and therapy including systematic biobanking, novel imaging techniques, and advanced molecular analysis by collecting comprehensive tumor tissues, liquid biopsies (whole blood, serum, plasma), and urine specimens (supernatant; sediment) as well as (ii) developing personalized lung cancer diagnostics based on tumor heterogeneity and integrated genomics, transcriptomics, metabolomics, and radiomics PET/MRI analysis. It will consist of 5 work packages. In this paper the rationale of the Polish MOBIT project as well as its design is presented. (iii) The project is to draw interest in and to invite national and international, private and public, preclinical and clinical initiatives to establish individualized and precise procedures for integrating novel targeted therapies and advanced imaging techniques. | ||
| 650 | 4 | |a Biobanking | |
| 650 | 4 | |a Lung Cancer | |
| 650 | 4 | |a Omics | |
| 650 | 4 | |a Personalized medicine | |
| 650 | 4 | |a Radiomics | |
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21 June 2017 |
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2017 |
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10.1016/j.advms.2017.05.002 doi (DE-627)1580403034 (DE-576)510403034 (DE-599)BSZ510403034 (OCoLC)1341017519 DE-627 ger DE-627 rda eng Nikliński, Jacek 1963- verfasserin (DE-588)1165527685 (DE-627)1029461155 (DE-576)510405215 aut Systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapy the Polish MOBIT project Jacek Niklinski, Adam Kretowski, Marcin Moniuszko, Joanna Reszec, Anna Michalska-Falkowska, Magdalena Niemira, Michal Ciborowski, Radoslaw Charkiewicz, Dorota Jurgilewicz, Miroslaw Kozlowski, Rodryg Ramlau, Cezary Piwkowski, Miroslaw Kwasniewski, Monika Kaczmarek, Andrzej Ciereszko, Tomasz Wasniewski, Robert Mroz, Wojciech Naumnik, Ewa Sierko, Magdalena Paczkowska, Joanna Kisluk, Anetta Sulewska, Adam Cybulski, Zenon Mariak, Boguslaw Kedra, Jacek Szamatowicz, Paweł Kurzawa, Lukasz Minarowski, Angelika Edyta Charkiewicz, Barbara Mroczko, Jolanta Malyszko, Christian Manegold, Lothar Pilz, Heike Allgayer, Mohammed L. Abba, Hartmut Juhl, Frauke Koch, the MOBIT Study Group 21 June 2017 9 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 27.08.2018 Available online 21 June 2017 Personalized and precision medicine is gaining recognition due to the limitations by standard diagnosis and treatment; many areas of medicine, from cancer to psychiatry, are moving towards tailored and individualized treatment for patients based on their clinical characteristics and genetic signatures as well as novel imaging techniques. Advances in whole genome sequencing have led to identification of genes involved in a variety of diseases. Moreover, biomarkers indicating severity of disease or susceptibility to treatment are increasingly being characterized. The continued identification of new genes and biomarkers specific to disease subtypes and individual patients is essential and inevitable for translation into personalized medicine, in estimating both, disease risk and response to therapy. Taking into consideration the mostly unsolved necessity of tailored therapy in oncology the innovative project MOBIT (molecular biomarkers for individualized therapy) was designed. The aims of the project are: (i) establishing integrative management of precise tumor diagnosis and therapy including systematic biobanking, novel imaging techniques, and advanced molecular analysis by collecting comprehensive tumor tissues, liquid biopsies (whole blood, serum, plasma), and urine specimens (supernatant; sediment) as well as (ii) developing personalized lung cancer diagnostics based on tumor heterogeneity and integrated genomics, transcriptomics, metabolomics, and radiomics PET/MRI analysis. It will consist of 5 work packages. In this paper the rationale of the Polish MOBIT project as well as its design is presented. (iii) The project is to draw interest in and to invite national and international, private and public, preclinical and clinical initiatives to establish individualized and precise procedures for integrating novel targeted therapies and advanced imaging techniques. Biobanking Lung Cancer Omics Personalized medicine Radiomics Manegold, Christian 1946- verfasserin (DE-588)108614913 (DE-627)490287360 (DE-576)289617200 aut Pilz, Lothar R. 1954- verfasserin (DE-588)1036758621 (DE-627)751686107 (DE-576)38680799X aut Allgayer, Heike 1969- verfasserin (DE-588)1024987884 (DE-627)720854466 (DE-576)369805003 aut Abba, Mohammed L. 1974- verfasserin (DE-588)1024986101 (DE-627)720854369 (DE-576)369801407 aut Enthalten in Advances in medical sciences Amsterdam [u.a.] : Elsevier, 2006 62(2017), 2, Seite 405-413 Online-Ressource (DE-627)525874348 (DE-600)2273671-2 (DE-576)281335524 1898-4002 nnns volume:62 year:2017 number:2 pages:405-413 extent:9 http://dx.doi.org/10.1016/j.advms.2017.05.002 Verlag Resolving-System kostenfrei Volltext http://www.sciencedirect.com/science/article/pii/S189611261730041X Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 62 2017 2 405-413 9 2013 01 DE-16-250 302386568X 00 --%%-- --%%-- --%%-- --%%-- l01 27-08-18 2403 01 DE-LFER 3479612245 00 --%%-- --%%-- n --%%-- l01 25-05-19 2403 01 DE-LFER http://www.sciencedirect.com/science/article/pii/S189611261730041X 2013 01 DE-16-250 00 s hd2017 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_37 2013 01 DE-16-250 03 s s_9 2013 01 DE-16-250 04 p (DE-627)1448132754 Manegold, Christian 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_32 2013 01 DE-16-250 05 p (DE-627)1456808346 Pilz, Lothar R. 2013 01 DE-16-250 05 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_33 2013 01 DE-16-250 06 p (DE-627)1439807183 Allgayer, Heike 2013 01 DE-16-250 06 k (DE-627)1416467505 Chirurgische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_34 2013 01 DE-16-250 07 p (DE-627)1439807345 Abba, Mohammed L. 2013 01 DE-16-250 07 k (DE-627)1416467505 Chirurgische Klinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_35 |
| spelling |
10.1016/j.advms.2017.05.002 doi (DE-627)1580403034 (DE-576)510403034 (DE-599)BSZ510403034 (OCoLC)1341017519 DE-627 ger DE-627 rda eng Nikliński, Jacek 1963- verfasserin (DE-588)1165527685 (DE-627)1029461155 (DE-576)510405215 aut Systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapy the Polish MOBIT project Jacek Niklinski, Adam Kretowski, Marcin Moniuszko, Joanna Reszec, Anna Michalska-Falkowska, Magdalena Niemira, Michal Ciborowski, Radoslaw Charkiewicz, Dorota Jurgilewicz, Miroslaw Kozlowski, Rodryg Ramlau, Cezary Piwkowski, Miroslaw Kwasniewski, Monika Kaczmarek, Andrzej Ciereszko, Tomasz Wasniewski, Robert Mroz, Wojciech Naumnik, Ewa Sierko, Magdalena Paczkowska, Joanna Kisluk, Anetta Sulewska, Adam Cybulski, Zenon Mariak, Boguslaw Kedra, Jacek Szamatowicz, Paweł Kurzawa, Lukasz Minarowski, Angelika Edyta Charkiewicz, Barbara Mroczko, Jolanta Malyszko, Christian Manegold, Lothar Pilz, Heike Allgayer, Mohammed L. Abba, Hartmut Juhl, Frauke Koch, the MOBIT Study Group 21 June 2017 9 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 27.08.2018 Available online 21 June 2017 Personalized and precision medicine is gaining recognition due to the limitations by standard diagnosis and treatment; many areas of medicine, from cancer to psychiatry, are moving towards tailored and individualized treatment for patients based on their clinical characteristics and genetic signatures as well as novel imaging techniques. Advances in whole genome sequencing have led to identification of genes involved in a variety of diseases. Moreover, biomarkers indicating severity of disease or susceptibility to treatment are increasingly being characterized. The continued identification of new genes and biomarkers specific to disease subtypes and individual patients is essential and inevitable for translation into personalized medicine, in estimating both, disease risk and response to therapy. Taking into consideration the mostly unsolved necessity of tailored therapy in oncology the innovative project MOBIT (molecular biomarkers for individualized therapy) was designed. The aims of the project are: (i) establishing integrative management of precise tumor diagnosis and therapy including systematic biobanking, novel imaging techniques, and advanced molecular analysis by collecting comprehensive tumor tissues, liquid biopsies (whole blood, serum, plasma), and urine specimens (supernatant; sediment) as well as (ii) developing personalized lung cancer diagnostics based on tumor heterogeneity and integrated genomics, transcriptomics, metabolomics, and radiomics PET/MRI analysis. It will consist of 5 work packages. In this paper the rationale of the Polish MOBIT project as well as its design is presented. (iii) The project is to draw interest in and to invite national and international, private and public, preclinical and clinical initiatives to establish individualized and precise procedures for integrating novel targeted therapies and advanced imaging techniques. Biobanking Lung Cancer Omics Personalized medicine Radiomics Manegold, Christian 1946- verfasserin (DE-588)108614913 (DE-627)490287360 (DE-576)289617200 aut Pilz, Lothar R. 1954- verfasserin (DE-588)1036758621 (DE-627)751686107 (DE-576)38680799X aut Allgayer, Heike 1969- verfasserin (DE-588)1024987884 (DE-627)720854466 (DE-576)369805003 aut Abba, Mohammed L. 1974- verfasserin (DE-588)1024986101 (DE-627)720854369 (DE-576)369801407 aut Enthalten in Advances in medical sciences Amsterdam [u.a.] : Elsevier, 2006 62(2017), 2, Seite 405-413 Online-Ressource (DE-627)525874348 (DE-600)2273671-2 (DE-576)281335524 1898-4002 nnns volume:62 year:2017 number:2 pages:405-413 extent:9 http://dx.doi.org/10.1016/j.advms.2017.05.002 Verlag Resolving-System kostenfrei Volltext http://www.sciencedirect.com/science/article/pii/S189611261730041X Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 62 2017 2 405-413 9 2013 01 DE-16-250 302386568X 00 --%%-- --%%-- --%%-- --%%-- l01 27-08-18 2403 01 DE-LFER 3479612245 00 --%%-- --%%-- n --%%-- l01 25-05-19 2403 01 DE-LFER http://www.sciencedirect.com/science/article/pii/S189611261730041X 2013 01 DE-16-250 00 s hd2017 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_37 2013 01 DE-16-250 03 s s_9 2013 01 DE-16-250 04 p (DE-627)1448132754 Manegold, Christian 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_32 2013 01 DE-16-250 05 p (DE-627)1456808346 Pilz, Lothar R. 2013 01 DE-16-250 05 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_33 2013 01 DE-16-250 06 p (DE-627)1439807183 Allgayer, Heike 2013 01 DE-16-250 06 k (DE-627)1416467505 Chirurgische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_34 2013 01 DE-16-250 07 p (DE-627)1439807345 Abba, Mohammed L. 2013 01 DE-16-250 07 k (DE-627)1416467505 Chirurgische Klinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_35 |
| allfields_unstemmed |
10.1016/j.advms.2017.05.002 doi (DE-627)1580403034 (DE-576)510403034 (DE-599)BSZ510403034 (OCoLC)1341017519 DE-627 ger DE-627 rda eng Nikliński, Jacek 1963- verfasserin (DE-588)1165527685 (DE-627)1029461155 (DE-576)510405215 aut Systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapy the Polish MOBIT project Jacek Niklinski, Adam Kretowski, Marcin Moniuszko, Joanna Reszec, Anna Michalska-Falkowska, Magdalena Niemira, Michal Ciborowski, Radoslaw Charkiewicz, Dorota Jurgilewicz, Miroslaw Kozlowski, Rodryg Ramlau, Cezary Piwkowski, Miroslaw Kwasniewski, Monika Kaczmarek, Andrzej Ciereszko, Tomasz Wasniewski, Robert Mroz, Wojciech Naumnik, Ewa Sierko, Magdalena Paczkowska, Joanna Kisluk, Anetta Sulewska, Adam Cybulski, Zenon Mariak, Boguslaw Kedra, Jacek Szamatowicz, Paweł Kurzawa, Lukasz Minarowski, Angelika Edyta Charkiewicz, Barbara Mroczko, Jolanta Malyszko, Christian Manegold, Lothar Pilz, Heike Allgayer, Mohammed L. Abba, Hartmut Juhl, Frauke Koch, the MOBIT Study Group 21 June 2017 9 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 27.08.2018 Available online 21 June 2017 Personalized and precision medicine is gaining recognition due to the limitations by standard diagnosis and treatment; many areas of medicine, from cancer to psychiatry, are moving towards tailored and individualized treatment for patients based on their clinical characteristics and genetic signatures as well as novel imaging techniques. Advances in whole genome sequencing have led to identification of genes involved in a variety of diseases. Moreover, biomarkers indicating severity of disease or susceptibility to treatment are increasingly being characterized. The continued identification of new genes and biomarkers specific to disease subtypes and individual patients is essential and inevitable for translation into personalized medicine, in estimating both, disease risk and response to therapy. Taking into consideration the mostly unsolved necessity of tailored therapy in oncology the innovative project MOBIT (molecular biomarkers for individualized therapy) was designed. The aims of the project are: (i) establishing integrative management of precise tumor diagnosis and therapy including systematic biobanking, novel imaging techniques, and advanced molecular analysis by collecting comprehensive tumor tissues, liquid biopsies (whole blood, serum, plasma), and urine specimens (supernatant; sediment) as well as (ii) developing personalized lung cancer diagnostics based on tumor heterogeneity and integrated genomics, transcriptomics, metabolomics, and radiomics PET/MRI analysis. It will consist of 5 work packages. In this paper the rationale of the Polish MOBIT project as well as its design is presented. (iii) The project is to draw interest in and to invite national and international, private and public, preclinical and clinical initiatives to establish individualized and precise procedures for integrating novel targeted therapies and advanced imaging techniques. Biobanking Lung Cancer Omics Personalized medicine Radiomics Manegold, Christian 1946- verfasserin (DE-588)108614913 (DE-627)490287360 (DE-576)289617200 aut Pilz, Lothar R. 1954- verfasserin (DE-588)1036758621 (DE-627)751686107 (DE-576)38680799X aut Allgayer, Heike 1969- verfasserin (DE-588)1024987884 (DE-627)720854466 (DE-576)369805003 aut Abba, Mohammed L. 1974- verfasserin (DE-588)1024986101 (DE-627)720854369 (DE-576)369801407 aut Enthalten in Advances in medical sciences Amsterdam [u.a.] : Elsevier, 2006 62(2017), 2, Seite 405-413 Online-Ressource (DE-627)525874348 (DE-600)2273671-2 (DE-576)281335524 1898-4002 nnns volume:62 year:2017 number:2 pages:405-413 extent:9 http://dx.doi.org/10.1016/j.advms.2017.05.002 Verlag Resolving-System kostenfrei Volltext http://www.sciencedirect.com/science/article/pii/S189611261730041X Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 62 2017 2 405-413 9 2013 01 DE-16-250 302386568X 00 --%%-- --%%-- --%%-- --%%-- l01 27-08-18 2403 01 DE-LFER 3479612245 00 --%%-- --%%-- n --%%-- l01 25-05-19 2403 01 DE-LFER http://www.sciencedirect.com/science/article/pii/S189611261730041X 2013 01 DE-16-250 00 s hd2017 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_37 2013 01 DE-16-250 03 s s_9 2013 01 DE-16-250 04 p (DE-627)1448132754 Manegold, Christian 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_32 2013 01 DE-16-250 05 p (DE-627)1456808346 Pilz, Lothar R. 2013 01 DE-16-250 05 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_33 2013 01 DE-16-250 06 p (DE-627)1439807183 Allgayer, Heike 2013 01 DE-16-250 06 k (DE-627)1416467505 Chirurgische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_34 2013 01 DE-16-250 07 p (DE-627)1439807345 Abba, Mohammed L. 2013 01 DE-16-250 07 k (DE-627)1416467505 Chirurgische Klinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_35 |
| allfieldsGer |
10.1016/j.advms.2017.05.002 doi (DE-627)1580403034 (DE-576)510403034 (DE-599)BSZ510403034 (OCoLC)1341017519 DE-627 ger DE-627 rda eng Nikliński, Jacek 1963- verfasserin (DE-588)1165527685 (DE-627)1029461155 (DE-576)510405215 aut Systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapy the Polish MOBIT project Jacek Niklinski, Adam Kretowski, Marcin Moniuszko, Joanna Reszec, Anna Michalska-Falkowska, Magdalena Niemira, Michal Ciborowski, Radoslaw Charkiewicz, Dorota Jurgilewicz, Miroslaw Kozlowski, Rodryg Ramlau, Cezary Piwkowski, Miroslaw Kwasniewski, Monika Kaczmarek, Andrzej Ciereszko, Tomasz Wasniewski, Robert Mroz, Wojciech Naumnik, Ewa Sierko, Magdalena Paczkowska, Joanna Kisluk, Anetta Sulewska, Adam Cybulski, Zenon Mariak, Boguslaw Kedra, Jacek Szamatowicz, Paweł Kurzawa, Lukasz Minarowski, Angelika Edyta Charkiewicz, Barbara Mroczko, Jolanta Malyszko, Christian Manegold, Lothar Pilz, Heike Allgayer, Mohammed L. Abba, Hartmut Juhl, Frauke Koch, the MOBIT Study Group 21 June 2017 9 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 27.08.2018 Available online 21 June 2017 Personalized and precision medicine is gaining recognition due to the limitations by standard diagnosis and treatment; many areas of medicine, from cancer to psychiatry, are moving towards tailored and individualized treatment for patients based on their clinical characteristics and genetic signatures as well as novel imaging techniques. Advances in whole genome sequencing have led to identification of genes involved in a variety of diseases. Moreover, biomarkers indicating severity of disease or susceptibility to treatment are increasingly being characterized. The continued identification of new genes and biomarkers specific to disease subtypes and individual patients is essential and inevitable for translation into personalized medicine, in estimating both, disease risk and response to therapy. Taking into consideration the mostly unsolved necessity of tailored therapy in oncology the innovative project MOBIT (molecular biomarkers for individualized therapy) was designed. The aims of the project are: (i) establishing integrative management of precise tumor diagnosis and therapy including systematic biobanking, novel imaging techniques, and advanced molecular analysis by collecting comprehensive tumor tissues, liquid biopsies (whole blood, serum, plasma), and urine specimens (supernatant; sediment) as well as (ii) developing personalized lung cancer diagnostics based on tumor heterogeneity and integrated genomics, transcriptomics, metabolomics, and radiomics PET/MRI analysis. It will consist of 5 work packages. In this paper the rationale of the Polish MOBIT project as well as its design is presented. (iii) The project is to draw interest in and to invite national and international, private and public, preclinical and clinical initiatives to establish individualized and precise procedures for integrating novel targeted therapies and advanced imaging techniques. Biobanking Lung Cancer Omics Personalized medicine Radiomics Manegold, Christian 1946- verfasserin (DE-588)108614913 (DE-627)490287360 (DE-576)289617200 aut Pilz, Lothar R. 1954- verfasserin (DE-588)1036758621 (DE-627)751686107 (DE-576)38680799X aut Allgayer, Heike 1969- verfasserin (DE-588)1024987884 (DE-627)720854466 (DE-576)369805003 aut Abba, Mohammed L. 1974- verfasserin (DE-588)1024986101 (DE-627)720854369 (DE-576)369801407 aut Enthalten in Advances in medical sciences Amsterdam [u.a.] : Elsevier, 2006 62(2017), 2, Seite 405-413 Online-Ressource (DE-627)525874348 (DE-600)2273671-2 (DE-576)281335524 1898-4002 nnns volume:62 year:2017 number:2 pages:405-413 extent:9 http://dx.doi.org/10.1016/j.advms.2017.05.002 Verlag Resolving-System kostenfrei Volltext http://www.sciencedirect.com/science/article/pii/S189611261730041X Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 62 2017 2 405-413 9 2013 01 DE-16-250 302386568X 00 --%%-- --%%-- --%%-- --%%-- l01 27-08-18 2403 01 DE-LFER 3479612245 00 --%%-- --%%-- n --%%-- l01 25-05-19 2403 01 DE-LFER http://www.sciencedirect.com/science/article/pii/S189611261730041X 2013 01 DE-16-250 00 s hd2017 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_37 2013 01 DE-16-250 03 s s_9 2013 01 DE-16-250 04 p (DE-627)1448132754 Manegold, Christian 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_32 2013 01 DE-16-250 05 p (DE-627)1456808346 Pilz, Lothar R. 2013 01 DE-16-250 05 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_33 2013 01 DE-16-250 06 p (DE-627)1439807183 Allgayer, Heike 2013 01 DE-16-250 06 k (DE-627)1416467505 Chirurgische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_34 2013 01 DE-16-250 07 p (DE-627)1439807345 Abba, Mohammed L. 2013 01 DE-16-250 07 k (DE-627)1416467505 Chirurgische Klinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_35 |
| allfieldsSound |
10.1016/j.advms.2017.05.002 doi (DE-627)1580403034 (DE-576)510403034 (DE-599)BSZ510403034 (OCoLC)1341017519 DE-627 ger DE-627 rda eng Nikliński, Jacek 1963- verfasserin (DE-588)1165527685 (DE-627)1029461155 (DE-576)510405215 aut Systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapy the Polish MOBIT project Jacek Niklinski, Adam Kretowski, Marcin Moniuszko, Joanna Reszec, Anna Michalska-Falkowska, Magdalena Niemira, Michal Ciborowski, Radoslaw Charkiewicz, Dorota Jurgilewicz, Miroslaw Kozlowski, Rodryg Ramlau, Cezary Piwkowski, Miroslaw Kwasniewski, Monika Kaczmarek, Andrzej Ciereszko, Tomasz Wasniewski, Robert Mroz, Wojciech Naumnik, Ewa Sierko, Magdalena Paczkowska, Joanna Kisluk, Anetta Sulewska, Adam Cybulski, Zenon Mariak, Boguslaw Kedra, Jacek Szamatowicz, Paweł Kurzawa, Lukasz Minarowski, Angelika Edyta Charkiewicz, Barbara Mroczko, Jolanta Malyszko, Christian Manegold, Lothar Pilz, Heike Allgayer, Mohammed L. Abba, Hartmut Juhl, Frauke Koch, the MOBIT Study Group 21 June 2017 9 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 27.08.2018 Available online 21 June 2017 Personalized and precision medicine is gaining recognition due to the limitations by standard diagnosis and treatment; many areas of medicine, from cancer to psychiatry, are moving towards tailored and individualized treatment for patients based on their clinical characteristics and genetic signatures as well as novel imaging techniques. Advances in whole genome sequencing have led to identification of genes involved in a variety of diseases. Moreover, biomarkers indicating severity of disease or susceptibility to treatment are increasingly being characterized. The continued identification of new genes and biomarkers specific to disease subtypes and individual patients is essential and inevitable for translation into personalized medicine, in estimating both, disease risk and response to therapy. Taking into consideration the mostly unsolved necessity of tailored therapy in oncology the innovative project MOBIT (molecular biomarkers for individualized therapy) was designed. The aims of the project are: (i) establishing integrative management of precise tumor diagnosis and therapy including systematic biobanking, novel imaging techniques, and advanced molecular analysis by collecting comprehensive tumor tissues, liquid biopsies (whole blood, serum, plasma), and urine specimens (supernatant; sediment) as well as (ii) developing personalized lung cancer diagnostics based on tumor heterogeneity and integrated genomics, transcriptomics, metabolomics, and radiomics PET/MRI analysis. It will consist of 5 work packages. In this paper the rationale of the Polish MOBIT project as well as its design is presented. (iii) The project is to draw interest in and to invite national and international, private and public, preclinical and clinical initiatives to establish individualized and precise procedures for integrating novel targeted therapies and advanced imaging techniques. Biobanking Lung Cancer Omics Personalized medicine Radiomics Manegold, Christian 1946- verfasserin (DE-588)108614913 (DE-627)490287360 (DE-576)289617200 aut Pilz, Lothar R. 1954- verfasserin (DE-588)1036758621 (DE-627)751686107 (DE-576)38680799X aut Allgayer, Heike 1969- verfasserin (DE-588)1024987884 (DE-627)720854466 (DE-576)369805003 aut Abba, Mohammed L. 1974- verfasserin (DE-588)1024986101 (DE-627)720854369 (DE-576)369801407 aut Enthalten in Advances in medical sciences Amsterdam [u.a.] : Elsevier, 2006 62(2017), 2, Seite 405-413 Online-Ressource (DE-627)525874348 (DE-600)2273671-2 (DE-576)281335524 1898-4002 nnns volume:62 year:2017 number:2 pages:405-413 extent:9 http://dx.doi.org/10.1016/j.advms.2017.05.002 Verlag Resolving-System kostenfrei Volltext http://www.sciencedirect.com/science/article/pii/S189611261730041X Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 62 2017 2 405-413 9 2013 01 DE-16-250 302386568X 00 --%%-- --%%-- --%%-- --%%-- l01 27-08-18 2403 01 DE-LFER 3479612245 00 --%%-- --%%-- n --%%-- l01 25-05-19 2403 01 DE-LFER http://www.sciencedirect.com/science/article/pii/S189611261730041X 2013 01 DE-16-250 00 s hd2017 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_37 2013 01 DE-16-250 03 s s_9 2013 01 DE-16-250 04 p (DE-627)1448132754 Manegold, Christian 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_32 2013 01 DE-16-250 05 p (DE-627)1456808346 Pilz, Lothar R. 2013 01 DE-16-250 05 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_33 2013 01 DE-16-250 06 p (DE-627)1439807183 Allgayer, Heike 2013 01 DE-16-250 06 k (DE-627)1416467505 Chirurgische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_34 2013 01 DE-16-250 07 p (DE-627)1439807345 Abba, Mohammed L. 2013 01 DE-16-250 07 k (DE-627)1416467505 Chirurgische Klinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_35 |
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Nikliński, Jacek @@aut@@ Manegold, Christian @@aut@@ Pilz, Lothar R. @@aut@@ Allgayer, Heike @@aut@@ Abba, Mohammed L. @@aut@@ |
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Systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapy the Polish MOBIT project |
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Systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapy the Polish MOBIT project Jacek Niklinski, Adam Kretowski, Marcin Moniuszko, Joanna Reszec, Anna Michalska-Falkowska, Magdalena Niemira, Michal Ciborowski, Radoslaw Charkiewicz, Dorota Jurgilewicz, Miroslaw Kozlowski, Rodryg Ramlau, Cezary Piwkowski, Miroslaw Kwasniewski, Monika Kaczmarek, Andrzej Ciereszko, Tomasz Wasniewski, Robert Mroz, Wojciech Naumnik, Ewa Sierko, Magdalena Paczkowska, Joanna Kisluk, Anetta Sulewska, Adam Cybulski, Zenon Mariak, Boguslaw Kedra, Jacek Szamatowicz, Paweł Kurzawa, Lukasz Minarowski, Angelika Edyta Charkiewicz, Barbara Mroczko, Jolanta Malyszko, Christian Manegold, Lothar Pilz, Heike Allgayer, Mohammed L. Abba, Hartmut Juhl, Frauke Koch, the MOBIT Study Group |
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Nikliński, Jacek 1963- |
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the Polish MOBIT project |
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systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapythe polish mobit project |
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Systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapy the Polish MOBIT project |
| abstract |
Personalized and precision medicine is gaining recognition due to the limitations by standard diagnosis and treatment; many areas of medicine, from cancer to psychiatry, are moving towards tailored and individualized treatment for patients based on their clinical characteristics and genetic signatures as well as novel imaging techniques. Advances in whole genome sequencing have led to identification of genes involved in a variety of diseases. Moreover, biomarkers indicating severity of disease or susceptibility to treatment are increasingly being characterized. The continued identification of new genes and biomarkers specific to disease subtypes and individual patients is essential and inevitable for translation into personalized medicine, in estimating both, disease risk and response to therapy. Taking into consideration the mostly unsolved necessity of tailored therapy in oncology the innovative project MOBIT (molecular biomarkers for individualized therapy) was designed. The aims of the project are: (i) establishing integrative management of precise tumor diagnosis and therapy including systematic biobanking, novel imaging techniques, and advanced molecular analysis by collecting comprehensive tumor tissues, liquid biopsies (whole blood, serum, plasma), and urine specimens (supernatant; sediment) as well as (ii) developing personalized lung cancer diagnostics based on tumor heterogeneity and integrated genomics, transcriptomics, metabolomics, and radiomics PET/MRI analysis. It will consist of 5 work packages. In this paper the rationale of the Polish MOBIT project as well as its design is presented. (iii) The project is to draw interest in and to invite national and international, private and public, preclinical and clinical initiatives to establish individualized and precise procedures for integrating novel targeted therapies and advanced imaging techniques. Gesehen am 27.08.2018 Available online 21 June 2017 |
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Personalized and precision medicine is gaining recognition due to the limitations by standard diagnosis and treatment; many areas of medicine, from cancer to psychiatry, are moving towards tailored and individualized treatment for patients based on their clinical characteristics and genetic signatures as well as novel imaging techniques. Advances in whole genome sequencing have led to identification of genes involved in a variety of diseases. Moreover, biomarkers indicating severity of disease or susceptibility to treatment are increasingly being characterized. The continued identification of new genes and biomarkers specific to disease subtypes and individual patients is essential and inevitable for translation into personalized medicine, in estimating both, disease risk and response to therapy. Taking into consideration the mostly unsolved necessity of tailored therapy in oncology the innovative project MOBIT (molecular biomarkers for individualized therapy) was designed. The aims of the project are: (i) establishing integrative management of precise tumor diagnosis and therapy including systematic biobanking, novel imaging techniques, and advanced molecular analysis by collecting comprehensive tumor tissues, liquid biopsies (whole blood, serum, plasma), and urine specimens (supernatant; sediment) as well as (ii) developing personalized lung cancer diagnostics based on tumor heterogeneity and integrated genomics, transcriptomics, metabolomics, and radiomics PET/MRI analysis. It will consist of 5 work packages. In this paper the rationale of the Polish MOBIT project as well as its design is presented. (iii) The project is to draw interest in and to invite national and international, private and public, preclinical and clinical initiatives to establish individualized and precise procedures for integrating novel targeted therapies and advanced imaging techniques. Gesehen am 27.08.2018 Available online 21 June 2017 |
| abstract_unstemmed |
Personalized and precision medicine is gaining recognition due to the limitations by standard diagnosis and treatment; many areas of medicine, from cancer to psychiatry, are moving towards tailored and individualized treatment for patients based on their clinical characteristics and genetic signatures as well as novel imaging techniques. Advances in whole genome sequencing have led to identification of genes involved in a variety of diseases. Moreover, biomarkers indicating severity of disease or susceptibility to treatment are increasingly being characterized. The continued identification of new genes and biomarkers specific to disease subtypes and individual patients is essential and inevitable for translation into personalized medicine, in estimating both, disease risk and response to therapy. Taking into consideration the mostly unsolved necessity of tailored therapy in oncology the innovative project MOBIT (molecular biomarkers for individualized therapy) was designed. The aims of the project are: (i) establishing integrative management of precise tumor diagnosis and therapy including systematic biobanking, novel imaging techniques, and advanced molecular analysis by collecting comprehensive tumor tissues, liquid biopsies (whole blood, serum, plasma), and urine specimens (supernatant; sediment) as well as (ii) developing personalized lung cancer diagnostics based on tumor heterogeneity and integrated genomics, transcriptomics, metabolomics, and radiomics PET/MRI analysis. It will consist of 5 work packages. In this paper the rationale of the Polish MOBIT project as well as its design is presented. (iii) The project is to draw interest in and to invite national and international, private and public, preclinical and clinical initiatives to establish individualized and precise procedures for integrating novel targeted therapies and advanced imaging techniques. Gesehen am 27.08.2018 Available online 21 June 2017 |
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