Time-resolved MR angiography of renal artery stenosis in a swine model at 3 Tesla using gadobutrol with digital subtraction angiography correlation
Purpose: To establish the minimum dose required for detection of renal artery stenosis using high temporal resolution, contrast enhanced MR angiography (MRA) in a porcine model. Materials and Methods: Surgically created renal artery stenoses were imaged with 3 Tesla MR and digital subtraction angiog...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Morelli, John N. [verfasserIn] Michaely, Henrik J. M. - 1976- [verfasserIn] Schönberg, Stefan - 1969- [verfasserIn] Attenberger, Ulrike - 1980- [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
29 May 2012 |
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| Schlagwörter: |
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| Anmerkung: |
Gesehen am 12.11.2018 |
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| Umfang: |
10 |
| Übergeordnetes Werk: |
Enthalten in: Journal of magnetic resonance imaging - New York, NY : Wiley-Liss, 1991, 36(2012), 3, Seite 704-713 |
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| Übergeordnetes Werk: |
volume:36 ; year:2012 ; number:3 ; pages:704-713 ; extent:10 |
| Links: |
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| DOI / URN: |
10.1002/jmri.23696 |
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| Katalog-ID: |
1583621180 |
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| 245 | 1 | 0 | |a Time-resolved MR angiography of renal artery stenosis in a swine model at 3 Tesla using gadobutrol with digital subtraction angiography correlation |c John N. Morelli, Fei Ai, MD, Val M. Runge, MD, Wei Zhang, MD, Xiaoming Li, MD, PhD, Peter Schmitt, PhD, Gary McNeal, MT, RT, Henrick J. Michaely, MD, Stefan O. Schoenberg, MD, Matthew Miller, DVM, Clint M. Gerdes, MD, Spencer T. Sincleair, MD, Heidi Spratt, PhD, and Ulrike I. Attenberger, MD |
| 246 | 3 | 3 | |a Time-resolved MR angiography of renal artery stenosis in a swine model at three Tesla using gadobutrol with digital subtraction angiography correlation |
| 264 | 1 | |c 29 May 2012 | |
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| 520 | |a Purpose: To establish the minimum dose required for detection of renal artery stenosis using high temporal resolution, contrast enhanced MR angiography (MRA) in a porcine model. Materials and Methods: Surgically created renal artery stenoses were imaged with 3 Tesla MR and digital subtraction angiography (DSA) in 12 swine in this IACUC approved protocol. Gadobutrol was injected intravenously at doses of 0.5, 1, 2, and 4 mL for time-resolved MRA (1.5 × 1.5 mm2 spatial resolution). Region of interest analysis was performed together with stenosis assessment and qualitative evaluation by two blinded readers. Results: Mean signal to noise ratio (SNR) and contrast to noise ratio (CNR) values were statistically significantly less with the 0.5-mL protocol (P < 0.001). There were no statistically significant differences among the other evaluated doses. Both readers found 10/12 cases with the 0.5-mL protocol to be of inadequate diagnostic quality (κ = 1.0). All other scans were found to be adequate for diagnosis. Accuracies in distinguishing between mild/insignificant (<50%) and higher grade stenoses (>50%) were comparable among the higher-dose protocols (sensitivities 73-93%, specificities 62-100%). Conclusion: Renal artery stenosis can be assessed with very low doses (∼0.025 mmol/kg bodyweight) of a high concentration, high relaxivity gadolinium chelate formulation in a swine model, results which are promising with respect to limiting exposure to gadolinium based contrast agents. J. Magn. Reson. Imaging 2012;36:704-713. © 2012 Wiley Periodicals, Inc. | ||
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29 May 2012 |
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10.1002/jmri.23696 doi (DE-627)1583621180 (DE-576)513621180 (DE-599)BSZ513621180 (OCoLC)1341022496 DE-627 ger DE-627 rda eng Morelli, John N. verfasserin (DE-588)143389491 (DE-627)704472864 (DE-576)337212228 aut Time-resolved MR angiography of renal artery stenosis in a swine model at 3 Tesla using gadobutrol with digital subtraction angiography correlation John N. Morelli, Fei Ai, MD, Val M. Runge, MD, Wei Zhang, MD, Xiaoming Li, MD, PhD, Peter Schmitt, PhD, Gary McNeal, MT, RT, Henrick J. Michaely, MD, Stefan O. Schoenberg, MD, Matthew Miller, DVM, Clint M. Gerdes, MD, Spencer T. Sincleair, MD, Heidi Spratt, PhD, and Ulrike I. Attenberger, MD Time-resolved MR angiography of renal artery stenosis in a swine model at three Tesla using gadobutrol with digital subtraction angiography correlation 29 May 2012 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 12.11.2018 Purpose: To establish the minimum dose required for detection of renal artery stenosis using high temporal resolution, contrast enhanced MR angiography (MRA) in a porcine model. Materials and Methods: Surgically created renal artery stenoses were imaged with 3 Tesla MR and digital subtraction angiography (DSA) in 12 swine in this IACUC approved protocol. Gadobutrol was injected intravenously at doses of 0.5, 1, 2, and 4 mL for time-resolved MRA (1.5 × 1.5 mm2 spatial resolution). Region of interest analysis was performed together with stenosis assessment and qualitative evaluation by two blinded readers. Results: Mean signal to noise ratio (SNR) and contrast to noise ratio (CNR) values were statistically significantly less with the 0.5-mL protocol (P < 0.001). There were no statistically significant differences among the other evaluated doses. Both readers found 10/12 cases with the 0.5-mL protocol to be of inadequate diagnostic quality (κ = 1.0). All other scans were found to be adequate for diagnosis. Accuracies in distinguishing between mild/insignificant (<50%) and higher grade stenoses (>50%) were comparable among the higher-dose protocols (sensitivities 73-93%, specificities 62-100%). Conclusion: Renal artery stenosis can be assessed with very low doses (∼0.025 mmol/kg bodyweight) of a high concentration, high relaxivity gadolinium chelate formulation in a swine model, results which are promising with respect to limiting exposure to gadolinium based contrast agents. J. Magn. Reson. Imaging 2012;36:704-713. © 2012 Wiley Periodicals, Inc. gadobutrol MRA time-resolved MRA Michaely, Henrik J. M. 1976- verfasserin (DE-588)128817283 (DE-627)381568407 (DE-576)297347624 aut Schönberg, Stefan 1969- verfasserin (DE-588)131557912 (DE-627)510700624 (DE-576)298584891 aut Attenberger, Ulrike 1980- verfasserin (DE-588)131554859 (DE-627)510698557 (DE-576)298582775 aut Enthalten in Journal of magnetic resonance imaging New York, NY : Wiley-Liss, 1991 36(2012), 3, Seite 704-713 Online-Ressource (DE-627)306360039 (DE-600)1497154-9 (DE-576)114617252 1522-2586 nnns volume:36 year:2012 number:3 pages:704-713 extent:10 http://dx.doi.org/10.1002/jmri.23696 Verlag Resolving-System Volltext http://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.23696 Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 36 2012 3 704-713 10 2013 01 DE-16-250 3032044790 00 --%%-- --%%-- --%%-- --%%-- l01 12-11-18 2013 01 DE-16-250 00 s hd2012 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_14 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1429556366 Michaely, Henrik J. M. 2013 01 DE-16-250 04 k (DE-627)1416468056 Institut für Klinische Radiologie und Nuklearmedizin 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_8 2013 01 DE-16-250 05 p (DE-627)1430613904 Schönberg, Stefan 2013 01 DE-16-250 05 k (DE-627)1416468056 Institut für Klinische Radiologie und Nuklearmedizin 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_9 2013 01 DE-16-250 06 p (DE-627)1430612703 Attenberger, Ulrike 2013 01 DE-16-250 06 k (DE-627)1416468056 Institut für Klinische Radiologie und Nuklearmedizin 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_14 |
| spelling |
10.1002/jmri.23696 doi (DE-627)1583621180 (DE-576)513621180 (DE-599)BSZ513621180 (OCoLC)1341022496 DE-627 ger DE-627 rda eng Morelli, John N. verfasserin (DE-588)143389491 (DE-627)704472864 (DE-576)337212228 aut Time-resolved MR angiography of renal artery stenosis in a swine model at 3 Tesla using gadobutrol with digital subtraction angiography correlation John N. Morelli, Fei Ai, MD, Val M. Runge, MD, Wei Zhang, MD, Xiaoming Li, MD, PhD, Peter Schmitt, PhD, Gary McNeal, MT, RT, Henrick J. Michaely, MD, Stefan O. Schoenberg, MD, Matthew Miller, DVM, Clint M. Gerdes, MD, Spencer T. Sincleair, MD, Heidi Spratt, PhD, and Ulrike I. Attenberger, MD Time-resolved MR angiography of renal artery stenosis in a swine model at three Tesla using gadobutrol with digital subtraction angiography correlation 29 May 2012 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 12.11.2018 Purpose: To establish the minimum dose required for detection of renal artery stenosis using high temporal resolution, contrast enhanced MR angiography (MRA) in a porcine model. Materials and Methods: Surgically created renal artery stenoses were imaged with 3 Tesla MR and digital subtraction angiography (DSA) in 12 swine in this IACUC approved protocol. Gadobutrol was injected intravenously at doses of 0.5, 1, 2, and 4 mL for time-resolved MRA (1.5 × 1.5 mm2 spatial resolution). Region of interest analysis was performed together with stenosis assessment and qualitative evaluation by two blinded readers. Results: Mean signal to noise ratio (SNR) and contrast to noise ratio (CNR) values were statistically significantly less with the 0.5-mL protocol (P < 0.001). There were no statistically significant differences among the other evaluated doses. Both readers found 10/12 cases with the 0.5-mL protocol to be of inadequate diagnostic quality (κ = 1.0). All other scans were found to be adequate for diagnosis. Accuracies in distinguishing between mild/insignificant (<50%) and higher grade stenoses (>50%) were comparable among the higher-dose protocols (sensitivities 73-93%, specificities 62-100%). Conclusion: Renal artery stenosis can be assessed with very low doses (∼0.025 mmol/kg bodyweight) of a high concentration, high relaxivity gadolinium chelate formulation in a swine model, results which are promising with respect to limiting exposure to gadolinium based contrast agents. J. Magn. Reson. Imaging 2012;36:704-713. © 2012 Wiley Periodicals, Inc. gadobutrol MRA time-resolved MRA Michaely, Henrik J. M. 1976- verfasserin (DE-588)128817283 (DE-627)381568407 (DE-576)297347624 aut Schönberg, Stefan 1969- verfasserin (DE-588)131557912 (DE-627)510700624 (DE-576)298584891 aut Attenberger, Ulrike 1980- verfasserin (DE-588)131554859 (DE-627)510698557 (DE-576)298582775 aut Enthalten in Journal of magnetic resonance imaging New York, NY : Wiley-Liss, 1991 36(2012), 3, Seite 704-713 Online-Ressource (DE-627)306360039 (DE-600)1497154-9 (DE-576)114617252 1522-2586 nnns volume:36 year:2012 number:3 pages:704-713 extent:10 http://dx.doi.org/10.1002/jmri.23696 Verlag Resolving-System Volltext http://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.23696 Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 36 2012 3 704-713 10 2013 01 DE-16-250 3032044790 00 --%%-- --%%-- --%%-- --%%-- l01 12-11-18 2013 01 DE-16-250 00 s hd2012 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_14 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1429556366 Michaely, Henrik J. M. 2013 01 DE-16-250 04 k (DE-627)1416468056 Institut für Klinische Radiologie und Nuklearmedizin 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_8 2013 01 DE-16-250 05 p (DE-627)1430613904 Schönberg, Stefan 2013 01 DE-16-250 05 k (DE-627)1416468056 Institut für Klinische Radiologie und Nuklearmedizin 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_9 2013 01 DE-16-250 06 p (DE-627)1430612703 Attenberger, Ulrike 2013 01 DE-16-250 06 k (DE-627)1416468056 Institut für Klinische Radiologie und Nuklearmedizin 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_14 |
| allfields_unstemmed |
10.1002/jmri.23696 doi (DE-627)1583621180 (DE-576)513621180 (DE-599)BSZ513621180 (OCoLC)1341022496 DE-627 ger DE-627 rda eng Morelli, John N. verfasserin (DE-588)143389491 (DE-627)704472864 (DE-576)337212228 aut Time-resolved MR angiography of renal artery stenosis in a swine model at 3 Tesla using gadobutrol with digital subtraction angiography correlation John N. Morelli, Fei Ai, MD, Val M. Runge, MD, Wei Zhang, MD, Xiaoming Li, MD, PhD, Peter Schmitt, PhD, Gary McNeal, MT, RT, Henrick J. Michaely, MD, Stefan O. Schoenberg, MD, Matthew Miller, DVM, Clint M. Gerdes, MD, Spencer T. Sincleair, MD, Heidi Spratt, PhD, and Ulrike I. Attenberger, MD Time-resolved MR angiography of renal artery stenosis in a swine model at three Tesla using gadobutrol with digital subtraction angiography correlation 29 May 2012 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 12.11.2018 Purpose: To establish the minimum dose required for detection of renal artery stenosis using high temporal resolution, contrast enhanced MR angiography (MRA) in a porcine model. Materials and Methods: Surgically created renal artery stenoses were imaged with 3 Tesla MR and digital subtraction angiography (DSA) in 12 swine in this IACUC approved protocol. Gadobutrol was injected intravenously at doses of 0.5, 1, 2, and 4 mL for time-resolved MRA (1.5 × 1.5 mm2 spatial resolution). Region of interest analysis was performed together with stenosis assessment and qualitative evaluation by two blinded readers. Results: Mean signal to noise ratio (SNR) and contrast to noise ratio (CNR) values were statistically significantly less with the 0.5-mL protocol (P < 0.001). There were no statistically significant differences among the other evaluated doses. Both readers found 10/12 cases with the 0.5-mL protocol to be of inadequate diagnostic quality (κ = 1.0). All other scans were found to be adequate for diagnosis. Accuracies in distinguishing between mild/insignificant (<50%) and higher grade stenoses (>50%) were comparable among the higher-dose protocols (sensitivities 73-93%, specificities 62-100%). Conclusion: Renal artery stenosis can be assessed with very low doses (∼0.025 mmol/kg bodyweight) of a high concentration, high relaxivity gadolinium chelate formulation in a swine model, results which are promising with respect to limiting exposure to gadolinium based contrast agents. J. Magn. Reson. Imaging 2012;36:704-713. © 2012 Wiley Periodicals, Inc. gadobutrol MRA time-resolved MRA Michaely, Henrik J. M. 1976- verfasserin (DE-588)128817283 (DE-627)381568407 (DE-576)297347624 aut Schönberg, Stefan 1969- verfasserin (DE-588)131557912 (DE-627)510700624 (DE-576)298584891 aut Attenberger, Ulrike 1980- verfasserin (DE-588)131554859 (DE-627)510698557 (DE-576)298582775 aut Enthalten in Journal of magnetic resonance imaging New York, NY : Wiley-Liss, 1991 36(2012), 3, Seite 704-713 Online-Ressource (DE-627)306360039 (DE-600)1497154-9 (DE-576)114617252 1522-2586 nnns volume:36 year:2012 number:3 pages:704-713 extent:10 http://dx.doi.org/10.1002/jmri.23696 Verlag Resolving-System Volltext http://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.23696 Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 36 2012 3 704-713 10 2013 01 DE-16-250 3032044790 00 --%%-- --%%-- --%%-- --%%-- l01 12-11-18 2013 01 DE-16-250 00 s hd2012 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_14 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1429556366 Michaely, Henrik J. M. 2013 01 DE-16-250 04 k (DE-627)1416468056 Institut für Klinische Radiologie und Nuklearmedizin 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_8 2013 01 DE-16-250 05 p (DE-627)1430613904 Schönberg, Stefan 2013 01 DE-16-250 05 k (DE-627)1416468056 Institut für Klinische Radiologie und Nuklearmedizin 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_9 2013 01 DE-16-250 06 p (DE-627)1430612703 Attenberger, Ulrike 2013 01 DE-16-250 06 k (DE-627)1416468056 Institut für Klinische Radiologie und Nuklearmedizin 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_14 |
| allfieldsGer |
10.1002/jmri.23696 doi (DE-627)1583621180 (DE-576)513621180 (DE-599)BSZ513621180 (OCoLC)1341022496 DE-627 ger DE-627 rda eng Morelli, John N. verfasserin (DE-588)143389491 (DE-627)704472864 (DE-576)337212228 aut Time-resolved MR angiography of renal artery stenosis in a swine model at 3 Tesla using gadobutrol with digital subtraction angiography correlation John N. Morelli, Fei Ai, MD, Val M. Runge, MD, Wei Zhang, MD, Xiaoming Li, MD, PhD, Peter Schmitt, PhD, Gary McNeal, MT, RT, Henrick J. Michaely, MD, Stefan O. Schoenberg, MD, Matthew Miller, DVM, Clint M. Gerdes, MD, Spencer T. Sincleair, MD, Heidi Spratt, PhD, and Ulrike I. Attenberger, MD Time-resolved MR angiography of renal artery stenosis in a swine model at three Tesla using gadobutrol with digital subtraction angiography correlation 29 May 2012 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 12.11.2018 Purpose: To establish the minimum dose required for detection of renal artery stenosis using high temporal resolution, contrast enhanced MR angiography (MRA) in a porcine model. Materials and Methods: Surgically created renal artery stenoses were imaged with 3 Tesla MR and digital subtraction angiography (DSA) in 12 swine in this IACUC approved protocol. Gadobutrol was injected intravenously at doses of 0.5, 1, 2, and 4 mL for time-resolved MRA (1.5 × 1.5 mm2 spatial resolution). Region of interest analysis was performed together with stenosis assessment and qualitative evaluation by two blinded readers. Results: Mean signal to noise ratio (SNR) and contrast to noise ratio (CNR) values were statistically significantly less with the 0.5-mL protocol (P < 0.001). There were no statistically significant differences among the other evaluated doses. Both readers found 10/12 cases with the 0.5-mL protocol to be of inadequate diagnostic quality (κ = 1.0). All other scans were found to be adequate for diagnosis. Accuracies in distinguishing between mild/insignificant (<50%) and higher grade stenoses (>50%) were comparable among the higher-dose protocols (sensitivities 73-93%, specificities 62-100%). Conclusion: Renal artery stenosis can be assessed with very low doses (∼0.025 mmol/kg bodyweight) of a high concentration, high relaxivity gadolinium chelate formulation in a swine model, results which are promising with respect to limiting exposure to gadolinium based contrast agents. J. Magn. Reson. Imaging 2012;36:704-713. © 2012 Wiley Periodicals, Inc. gadobutrol MRA time-resolved MRA Michaely, Henrik J. M. 1976- verfasserin (DE-588)128817283 (DE-627)381568407 (DE-576)297347624 aut Schönberg, Stefan 1969- verfasserin (DE-588)131557912 (DE-627)510700624 (DE-576)298584891 aut Attenberger, Ulrike 1980- verfasserin (DE-588)131554859 (DE-627)510698557 (DE-576)298582775 aut Enthalten in Journal of magnetic resonance imaging New York, NY : Wiley-Liss, 1991 36(2012), 3, Seite 704-713 Online-Ressource (DE-627)306360039 (DE-600)1497154-9 (DE-576)114617252 1522-2586 nnns volume:36 year:2012 number:3 pages:704-713 extent:10 http://dx.doi.org/10.1002/jmri.23696 Verlag Resolving-System Volltext http://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.23696 Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 36 2012 3 704-713 10 2013 01 DE-16-250 3032044790 00 --%%-- --%%-- --%%-- --%%-- l01 12-11-18 2013 01 DE-16-250 00 s hd2012 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_14 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1429556366 Michaely, Henrik J. M. 2013 01 DE-16-250 04 k (DE-627)1416468056 Institut für Klinische Radiologie und Nuklearmedizin 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_8 2013 01 DE-16-250 05 p (DE-627)1430613904 Schönberg, Stefan 2013 01 DE-16-250 05 k (DE-627)1416468056 Institut für Klinische Radiologie und Nuklearmedizin 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_9 2013 01 DE-16-250 06 p (DE-627)1430612703 Attenberger, Ulrike 2013 01 DE-16-250 06 k (DE-627)1416468056 Institut für Klinische Radiologie und Nuklearmedizin 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_14 |
| allfieldsSound |
10.1002/jmri.23696 doi (DE-627)1583621180 (DE-576)513621180 (DE-599)BSZ513621180 (OCoLC)1341022496 DE-627 ger DE-627 rda eng Morelli, John N. verfasserin (DE-588)143389491 (DE-627)704472864 (DE-576)337212228 aut Time-resolved MR angiography of renal artery stenosis in a swine model at 3 Tesla using gadobutrol with digital subtraction angiography correlation John N. Morelli, Fei Ai, MD, Val M. Runge, MD, Wei Zhang, MD, Xiaoming Li, MD, PhD, Peter Schmitt, PhD, Gary McNeal, MT, RT, Henrick J. Michaely, MD, Stefan O. Schoenberg, MD, Matthew Miller, DVM, Clint M. Gerdes, MD, Spencer T. Sincleair, MD, Heidi Spratt, PhD, and Ulrike I. Attenberger, MD Time-resolved MR angiography of renal artery stenosis in a swine model at three Tesla using gadobutrol with digital subtraction angiography correlation 29 May 2012 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 12.11.2018 Purpose: To establish the minimum dose required for detection of renal artery stenosis using high temporal resolution, contrast enhanced MR angiography (MRA) in a porcine model. Materials and Methods: Surgically created renal artery stenoses were imaged with 3 Tesla MR and digital subtraction angiography (DSA) in 12 swine in this IACUC approved protocol. Gadobutrol was injected intravenously at doses of 0.5, 1, 2, and 4 mL for time-resolved MRA (1.5 × 1.5 mm2 spatial resolution). Region of interest analysis was performed together with stenosis assessment and qualitative evaluation by two blinded readers. Results: Mean signal to noise ratio (SNR) and contrast to noise ratio (CNR) values were statistically significantly less with the 0.5-mL protocol (P < 0.001). There were no statistically significant differences among the other evaluated doses. Both readers found 10/12 cases with the 0.5-mL protocol to be of inadequate diagnostic quality (κ = 1.0). All other scans were found to be adequate for diagnosis. Accuracies in distinguishing between mild/insignificant (<50%) and higher grade stenoses (>50%) were comparable among the higher-dose protocols (sensitivities 73-93%, specificities 62-100%). Conclusion: Renal artery stenosis can be assessed with very low doses (∼0.025 mmol/kg bodyweight) of a high concentration, high relaxivity gadolinium chelate formulation in a swine model, results which are promising with respect to limiting exposure to gadolinium based contrast agents. J. Magn. Reson. Imaging 2012;36:704-713. © 2012 Wiley Periodicals, Inc. gadobutrol MRA time-resolved MRA Michaely, Henrik J. 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Morelli, Fei Ai, MD, Val M. Runge, MD, Wei Zhang, MD, Xiaoming Li, MD, PhD, Peter Schmitt, PhD, Gary McNeal, MT, RT, Henrick J. Michaely, MD, Stefan O. Schoenberg, MD, Matthew Miller, DVM, Clint M. Gerdes, MD, Spencer T. Sincleair, MD, Heidi Spratt, PhD, and Ulrike I. Attenberger, MD</subfield></datafield><datafield tag="246" ind1="3" ind2="3"><subfield code="a">Time-resolved MR angiography of renal artery stenosis in a swine model at three Tesla using gadobutrol with digital subtraction angiography correlation</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">29 May 2012</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">10</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Gesehen am 12.11.2018</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose: To establish the minimum dose required for detection of renal artery stenosis using high temporal resolution, contrast enhanced MR angiography (MRA) in a porcine model. 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Time-resolved MR angiography of renal artery stenosis in a swine model at 3 Tesla using gadobutrol with digital subtraction angiography correlation John N. Morelli, Fei Ai, MD, Val M. Runge, MD, Wei Zhang, MD, Xiaoming Li, MD, PhD, Peter Schmitt, PhD, Gary McNeal, MT, RT, Henrick J. Michaely, MD, Stefan O. Schoenberg, MD, Matthew Miller, DVM, Clint M. Gerdes, MD, Spencer T. Sincleair, MD, Heidi Spratt, PhD, and Ulrike I. Attenberger, MD |
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time-resolved mr angiography of renal artery stenosis in a swine model at 3 tesla using gadobutrol with digital subtraction angiography correlation |
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Time-resolved MR angiography of renal artery stenosis in a swine model at 3 Tesla using gadobutrol with digital subtraction angiography correlation |
| abstract |
Purpose: To establish the minimum dose required for detection of renal artery stenosis using high temporal resolution, contrast enhanced MR angiography (MRA) in a porcine model. Materials and Methods: Surgically created renal artery stenoses were imaged with 3 Tesla MR and digital subtraction angiography (DSA) in 12 swine in this IACUC approved protocol. Gadobutrol was injected intravenously at doses of 0.5, 1, 2, and 4 mL for time-resolved MRA (1.5 × 1.5 mm2 spatial resolution). Region of interest analysis was performed together with stenosis assessment and qualitative evaluation by two blinded readers. Results: Mean signal to noise ratio (SNR) and contrast to noise ratio (CNR) values were statistically significantly less with the 0.5-mL protocol (P < 0.001). There were no statistically significant differences among the other evaluated doses. Both readers found 10/12 cases with the 0.5-mL protocol to be of inadequate diagnostic quality (κ = 1.0). All other scans were found to be adequate for diagnosis. Accuracies in distinguishing between mild/insignificant (<50%) and higher grade stenoses (>50%) were comparable among the higher-dose protocols (sensitivities 73-93%, specificities 62-100%). Conclusion: Renal artery stenosis can be assessed with very low doses (∼0.025 mmol/kg bodyweight) of a high concentration, high relaxivity gadolinium chelate formulation in a swine model, results which are promising with respect to limiting exposure to gadolinium based contrast agents. J. Magn. Reson. Imaging 2012;36:704-713. © 2012 Wiley Periodicals, Inc. Gesehen am 12.11.2018 |
| abstractGer |
Purpose: To establish the minimum dose required for detection of renal artery stenosis using high temporal resolution, contrast enhanced MR angiography (MRA) in a porcine model. Materials and Methods: Surgically created renal artery stenoses were imaged with 3 Tesla MR and digital subtraction angiography (DSA) in 12 swine in this IACUC approved protocol. Gadobutrol was injected intravenously at doses of 0.5, 1, 2, and 4 mL for time-resolved MRA (1.5 × 1.5 mm2 spatial resolution). Region of interest analysis was performed together with stenosis assessment and qualitative evaluation by two blinded readers. Results: Mean signal to noise ratio (SNR) and contrast to noise ratio (CNR) values were statistically significantly less with the 0.5-mL protocol (P < 0.001). There were no statistically significant differences among the other evaluated doses. Both readers found 10/12 cases with the 0.5-mL protocol to be of inadequate diagnostic quality (κ = 1.0). All other scans were found to be adequate for diagnosis. Accuracies in distinguishing between mild/insignificant (<50%) and higher grade stenoses (>50%) were comparable among the higher-dose protocols (sensitivities 73-93%, specificities 62-100%). Conclusion: Renal artery stenosis can be assessed with very low doses (∼0.025 mmol/kg bodyweight) of a high concentration, high relaxivity gadolinium chelate formulation in a swine model, results which are promising with respect to limiting exposure to gadolinium based contrast agents. J. Magn. Reson. Imaging 2012;36:704-713. © 2012 Wiley Periodicals, Inc. Gesehen am 12.11.2018 |
| abstract_unstemmed |
Purpose: To establish the minimum dose required for detection of renal artery stenosis using high temporal resolution, contrast enhanced MR angiography (MRA) in a porcine model. Materials and Methods: Surgically created renal artery stenoses were imaged with 3 Tesla MR and digital subtraction angiography (DSA) in 12 swine in this IACUC approved protocol. Gadobutrol was injected intravenously at doses of 0.5, 1, 2, and 4 mL for time-resolved MRA (1.5 × 1.5 mm2 spatial resolution). Region of interest analysis was performed together with stenosis assessment and qualitative evaluation by two blinded readers. Results: Mean signal to noise ratio (SNR) and contrast to noise ratio (CNR) values were statistically significantly less with the 0.5-mL protocol (P < 0.001). There were no statistically significant differences among the other evaluated doses. Both readers found 10/12 cases with the 0.5-mL protocol to be of inadequate diagnostic quality (κ = 1.0). All other scans were found to be adequate for diagnosis. Accuracies in distinguishing between mild/insignificant (<50%) and higher grade stenoses (>50%) were comparable among the higher-dose protocols (sensitivities 73-93%, specificities 62-100%). Conclusion: Renal artery stenosis can be assessed with very low doses (∼0.025 mmol/kg bodyweight) of a high concentration, high relaxivity gadolinium chelate formulation in a swine model, results which are promising with respect to limiting exposure to gadolinium based contrast agents. J. Magn. Reson. Imaging 2012;36:704-713. © 2012 Wiley Periodicals, Inc. Gesehen am 12.11.2018 |
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Time-resolved MR angiography of renal artery stenosis in a swine model at 3 Tesla using gadobutrol with digital subtraction angiography correlation |
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http://dx.doi.org/10.1002/jmri.23696 http://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.23696 |
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Michaely, Henrik J. M. 1976- Schönberg, Stefan 1969- Attenberger, Ulrike 1980- |
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Morelli, John N. Michaely, H. J. Michaely, Henrik Jakob Matthias Michaely, Henrick Henrik, Michaely Michaely, Henrik Michaely, Henrik J. Michaely, Henrik J. M. Schoenberg, Stefan O. Schönberg, Stefan O. Schönberg, S. O. Schönberg, Stephan Oswald Schönberg, Stefan Gerd Oswald Schoenberg, Stephan Oswald Schönberg, Stefan Oswald Schonberg, Stefan Schönberg, Stefan Attenberger, U. I. Attenberger, Ulrike Irmgard Attenberger, Ulrike I. Attenberger, Ulrike |
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Morelli, John N. Michaely, H. J. Michaely, Henrik Jakob Matthias Michaely, Henrick Henrik, Michaely Michaely, Henrik Michaely, Henrik J. Michaely, Henrik J. M. Schoenberg, Stefan O. Schönberg, Stefan O. Schönberg, S. O. Schönberg, Stephan Oswald Schönberg, Stefan Gerd Oswald Schoenberg, Stephan Oswald Schönberg, Stefan Oswald Schonberg, Stefan Schönberg, Stefan Attenberger, U. I. Attenberger, Ulrike Irmgard Attenberger, Ulrike I. Attenberger, Ulrike |
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Morelli, John N. Michaely, H. J. Michaely, Henrik Jakob Matthias Michaely, Henrick Henrik, Michaely Michaely, Henrik Michaely, Henrik J. Michaely, Henrik J. M. Schoenberg, Stefan O. Schönberg, Stefan O. Schönberg, S. O. Schönberg, Stephan Oswald Schönberg, Stefan Gerd Oswald Schoenberg, Stephan Oswald Schönberg, Stefan Oswald Schonberg, Stefan Schönberg, Stefan Attenberger, U. I. Attenberger, Ulrike Irmgard Attenberger, Ulrike I. Attenberger, Ulrike |
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