Right and left heart function in lowlanders with COPD at altitude : Data from a Randomized Study

Background: Changes in pulmonary hemodynamics and cardiac function in patients with chronic obstructive pulmonary disease (COPD) traveling to altitude have not been assessed despite an increasing prevalence of the disease. Objectives:...
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Autor*in:	Lichtblau, Mona - 1987- [verfasserIn] Latshang, Tsogyal D. [verfasserIn] Furian, Michael [verfasserIn] Müller-Mottet, Séverine [verfasserIn] Küest, Silke [verfasserIn] Tanner, Felix [verfasserIn] Grünig, Ekkehard [verfasserIn] Bloch, Konrad E. [verfasserIn] Ulrich, Silvia [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	February 2019

Anmerkung:	Gesehen am 27.06.2019
Umfang:	10

Übergeordnetes Werk:	Enthalten in: Respiration - Basel : Karger, 1944, 97(2019), 2, Seite 125-134
Übergeordnetes Werk:	volume:97 ; year:2019 ; number:2 ; pages:125-134 ; extent:10

Links:	Volltext Volltext

DOI / URN:	10.1159/000492898

Katalog-ID:	1668062364

Internformat


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245	1	0	\|a Right and left heart function in lowlanders with COPD at altitude \|b Data from a Randomized Study \|c Mona Lichtblau, Tsogyal D. Latshang, Michael Furian, Séverine Müller-Mottet, Silke Küest, Felix Tanner, Ekkehard Grünig, Konrad E. Bloch, Silvia Ulrich
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520			\|a <b><i>Background:</i></b> Changes in pulmonary hemodynamics and cardiac function in patients with chronic obstructive pulmonary disease (COPD) traveling to altitude have not been assessed despite an increasing prevalence of the disease. <b><i>Objectives:</i></b> We hypothesized that pulmonary artery pressure (PAP) significantly increases and cardiac function deteriorates during exposure to hypobaric hypoxia as encountered by traveling to moderate altitude or air flight. <b><i>Methods:</i></b> A total of 37 patients (17 female; median age [quartiles] 66 years [60; 69] with COPD GOLD grade 2-3 [FEV<sub>1</sub> 57% predicted (49; 71)]) living < 800 m underwent echocardiography in Zurich (490 m) and after 1 night at Davos Jakobshorn (2,590 m) in a randomized order of allocation. <b><i>Results:</i></b> The transtricuspid pressure gradient increased from 23 mm Hg (18; 29) to 32 mm Hg (25; 41) (<i>p</i> < 0.0001; Δmedian [95% CI] 7.5 [2.0; 13.0]), the right ventricular fractional area change decreased from 45% (39; 49) to 38% (33; 43) (<i>p</i> = 0.002), while the heart rate and systolic blood pressure increased from 70 bpm (64; 78) to 82 bpm (70; 86) (<i>p</i> < 0.0001) and from 133 mm Hg (123; 141) to 136 mm Hg (126; 148) (<i>p</i> = 0.002), respectively, and left ventricular diastolic dysfunction was more prevalent (24-54%, <i>p</i> = 0.02). <b><i>Conclusions:</i></b> This is a first study assessing changes in pulmonary hemodynamics and cardiac function in patients with COPD during a short altitude sojourn. Despite the increase in PAP and indications of change in cardiac function, the exposure was well tolerated. None of the patients had to descend to lower altitude for symptomatic altitude-related disease.
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Indexfelder

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matchkey_str	article:14230356:2019----::ihadeterfntoilwadrw
oclc_num	1341230170
hierarchy_sort_str	February 2019
publishDate	2019
allfields	10.1159/000492898 doi (DE-627)1668062364 (DE-599)KXP1668062364 (OCoLC)1341230170 DE-627 ger DE-627 rda eng Lichtblau, Mona 1987- verfasserin (DE-588)103170437X (DE-627)737155388 (DE-576)379407442 aut Right and left heart function in lowlanders with COPD at altitude Data from a Randomized Study Mona Lichtblau, Tsogyal D. Latshang, Michael Furian, Séverine Müller-Mottet, Silke Küest, Felix Tanner, Ekkehard Grünig, Konrad E. Bloch, Silvia Ulrich February 2019 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 27.06.2019 <b><i>Background:</i></b> Changes in pulmonary hemodynamics and cardiac function in patients with chronic obstructive pulmonary disease (COPD) traveling to altitude have not been assessed despite an increasing prevalence of the disease. <b><i>Objectives:</i></b> We hypothesized that pulmonary artery pressure (PAP) significantly increases and cardiac function deteriorates during exposure to hypobaric hypoxia as encountered by traveling to moderate altitude or air flight. <b><i>Methods:</i></b> A total of 37 patients (17 female; median age [quartiles] 66 years [60; 69] with COPD GOLD grade 2-3 [FEV<sub>1</sub> 57% predicted (49; 71)]) living < 800 m underwent echocardiography in Zurich (490 m) and after 1 night at Davos Jakobshorn (2,590 m) in a randomized order of allocation. <b><i>Results:</i></b> The transtricuspid pressure gradient increased from 23 mm Hg (18; 29) to 32 mm Hg (25; 41) (<i>p</i> < 0.0001; Δmedian [95% CI] 7.5 [2.0; 13.0]), the right ventricular fractional area change decreased from 45% (39; 49) to 38% (33; 43) (<i>p</i> = 0.002), while the heart rate and systolic blood pressure increased from 70 bpm (64; 78) to 82 bpm (70; 86) (<i>p</i> < 0.0001) and from 133 mm Hg (123; 141) to 136 mm Hg (126; 148) (<i>p</i> = 0.002), respectively, and left ventricular diastolic dysfunction was more prevalent (24-54%, <i>p</i> = 0.02). <b><i>Conclusions:</i></b> This is a first study assessing changes in pulmonary hemodynamics and cardiac function in patients with COPD during a short altitude sojourn. Despite the increase in PAP and indications of change in cardiac function, the exposure was well tolerated. None of the patients had to descend to lower altitude for symptomatic altitude-related disease. Latshang, Tsogyal D. verfasserin aut Furian, Michael verfasserin aut Müller-Mottet, Séverine verfasserin aut Küest, Silke verfasserin aut Tanner, Felix verfasserin aut Grünig, Ekkehard verfasserin (DE-588)112535801 (DE-627)618892605 (DE-576)31856694X aut Bloch, Konrad E. verfasserin aut Ulrich, Silvia verfasserin aut Enthalten in Respiration Basel : Karger, 1944 97(2019), 2, Seite 125-134 Online-Ressource (DE-627)26551035X (DE-600)1464419-8 (DE-576)112815111 1423-0356 nnns volume:97 year:2019 number:2 pages:125-134 extent:10 https://doi.org/10.1159/000492898 Verlag Resolving-System Volltext https://www.karger.com/Article/FullText/492898 Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2414 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4753 AR 97 2019 2 125-134 10 2013 01 DE-16-250 3490055713 00 --%%-- --%%-- --%%-- --%%-- l01 27-06-19 2013 01 DE-16-250 00 s hd2019 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_9 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1448671612 Grünig, Ekkehard 2013 01 DE-16-250 04 k (DE-627)1444845233 Thoraxklinik Heidelberg gGmbH 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_7
spelling	10.1159/000492898 doi (DE-627)1668062364 (DE-599)KXP1668062364 (OCoLC)1341230170 DE-627 ger DE-627 rda eng Lichtblau, Mona 1987- verfasserin (DE-588)103170437X (DE-627)737155388 (DE-576)379407442 aut Right and left heart function in lowlanders with COPD at altitude Data from a Randomized Study Mona Lichtblau, Tsogyal D. Latshang, Michael Furian, Séverine Müller-Mottet, Silke Küest, Felix Tanner, Ekkehard Grünig, Konrad E. Bloch, Silvia Ulrich February 2019 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 27.06.2019 <b><i>Background:</i></b> Changes in pulmonary hemodynamics and cardiac function in patients with chronic obstructive pulmonary disease (COPD) traveling to altitude have not been assessed despite an increasing prevalence of the disease. <b><i>Objectives:</i></b> We hypothesized that pulmonary artery pressure (PAP) significantly increases and cardiac function deteriorates during exposure to hypobaric hypoxia as encountered by traveling to moderate altitude or air flight. <b><i>Methods:</i></b> A total of 37 patients (17 female; median age [quartiles] 66 years [60; 69] with COPD GOLD grade 2-3 [FEV<sub>1</sub> 57% predicted (49; 71)]) living < 800 m underwent echocardiography in Zurich (490 m) and after 1 night at Davos Jakobshorn (2,590 m) in a randomized order of allocation. <b><i>Results:</i></b> The transtricuspid pressure gradient increased from 23 mm Hg (18; 29) to 32 mm Hg (25; 41) (<i>p</i> < 0.0001; Δmedian [95% CI] 7.5 [2.0; 13.0]), the right ventricular fractional area change decreased from 45% (39; 49) to 38% (33; 43) (<i>p</i> = 0.002), while the heart rate and systolic blood pressure increased from 70 bpm (64; 78) to 82 bpm (70; 86) (<i>p</i> < 0.0001) and from 133 mm Hg (123; 141) to 136 mm Hg (126; 148) (<i>p</i> = 0.002), respectively, and left ventricular diastolic dysfunction was more prevalent (24-54%, <i>p</i> = 0.02). <b><i>Conclusions:</i></b> This is a first study assessing changes in pulmonary hemodynamics and cardiac function in patients with COPD during a short altitude sojourn. Despite the increase in PAP and indications of change in cardiac function, the exposure was well tolerated. None of the patients had to descend to lower altitude for symptomatic altitude-related disease. Latshang, Tsogyal D. verfasserin aut Furian, Michael verfasserin aut Müller-Mottet, Séverine verfasserin aut Küest, Silke verfasserin aut Tanner, Felix verfasserin aut Grünig, Ekkehard verfasserin (DE-588)112535801 (DE-627)618892605 (DE-576)31856694X aut Bloch, Konrad E. verfasserin aut Ulrich, Silvia verfasserin aut Enthalten in Respiration Basel : Karger, 1944 97(2019), 2, Seite 125-134 Online-Ressource (DE-627)26551035X (DE-600)1464419-8 (DE-576)112815111 1423-0356 nnns volume:97 year:2019 number:2 pages:125-134 extent:10 https://doi.org/10.1159/000492898 Verlag Resolving-System Volltext https://www.karger.com/Article/FullText/492898 Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2414 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4753 AR 97 2019 2 125-134 10 2013 01 DE-16-250 3490055713 00 --%%-- --%%-- --%%-- --%%-- l01 27-06-19 2013 01 DE-16-250 00 s hd2019 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_9 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1448671612 Grünig, Ekkehard 2013 01 DE-16-250 04 k (DE-627)1444845233 Thoraxklinik Heidelberg gGmbH 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_7
allfields_unstemmed	10.1159/000492898 doi (DE-627)1668062364 (DE-599)KXP1668062364 (OCoLC)1341230170 DE-627 ger DE-627 rda eng Lichtblau, Mona 1987- verfasserin (DE-588)103170437X (DE-627)737155388 (DE-576)379407442 aut Right and left heart function in lowlanders with COPD at altitude Data from a Randomized Study Mona Lichtblau, Tsogyal D. Latshang, Michael Furian, Séverine Müller-Mottet, Silke Küest, Felix Tanner, Ekkehard Grünig, Konrad E. Bloch, Silvia Ulrich February 2019 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 27.06.2019 <b><i>Background:</i></b> Changes in pulmonary hemodynamics and cardiac function in patients with chronic obstructive pulmonary disease (COPD) traveling to altitude have not been assessed despite an increasing prevalence of the disease. <b><i>Objectives:</i></b> We hypothesized that pulmonary artery pressure (PAP) significantly increases and cardiac function deteriorates during exposure to hypobaric hypoxia as encountered by traveling to moderate altitude or air flight. <b><i>Methods:</i></b> A total of 37 patients (17 female; median age [quartiles] 66 years [60; 69] with COPD GOLD grade 2-3 [FEV<sub>1</sub> 57% predicted (49; 71)]) living < 800 m underwent echocardiography in Zurich (490 m) and after 1 night at Davos Jakobshorn (2,590 m) in a randomized order of allocation. <b><i>Results:</i></b> The transtricuspid pressure gradient increased from 23 mm Hg (18; 29) to 32 mm Hg (25; 41) (<i>p</i> < 0.0001; Δmedian [95% CI] 7.5 [2.0; 13.0]), the right ventricular fractional area change decreased from 45% (39; 49) to 38% (33; 43) (<i>p</i> = 0.002), while the heart rate and systolic blood pressure increased from 70 bpm (64; 78) to 82 bpm (70; 86) (<i>p</i> < 0.0001) and from 133 mm Hg (123; 141) to 136 mm Hg (126; 148) (<i>p</i> = 0.002), respectively, and left ventricular diastolic dysfunction was more prevalent (24-54%, <i>p</i> = 0.02). <b><i>Conclusions:</i></b> This is a first study assessing changes in pulmonary hemodynamics and cardiac function in patients with COPD during a short altitude sojourn. Despite the increase in PAP and indications of change in cardiac function, the exposure was well tolerated. None of the patients had to descend to lower altitude for symptomatic altitude-related disease. Latshang, Tsogyal D. verfasserin aut Furian, Michael verfasserin aut Müller-Mottet, Séverine verfasserin aut Küest, Silke verfasserin aut Tanner, Felix verfasserin aut Grünig, Ekkehard verfasserin (DE-588)112535801 (DE-627)618892605 (DE-576)31856694X aut Bloch, Konrad E. verfasserin aut Ulrich, Silvia verfasserin aut Enthalten in Respiration Basel : Karger, 1944 97(2019), 2, Seite 125-134 Online-Ressource (DE-627)26551035X (DE-600)1464419-8 (DE-576)112815111 1423-0356 nnns volume:97 year:2019 number:2 pages:125-134 extent:10 https://doi.org/10.1159/000492898 Verlag Resolving-System Volltext https://www.karger.com/Article/FullText/492898 Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2414 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4753 AR 97 2019 2 125-134 10 2013 01 DE-16-250 3490055713 00 --%%-- --%%-- --%%-- --%%-- l01 27-06-19 2013 01 DE-16-250 00 s hd2019 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_9 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1448671612 Grünig, Ekkehard 2013 01 DE-16-250 04 k (DE-627)1444845233 Thoraxklinik Heidelberg gGmbH 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_7
allfieldsGer	10.1159/000492898 doi (DE-627)1668062364 (DE-599)KXP1668062364 (OCoLC)1341230170 DE-627 ger DE-627 rda eng Lichtblau, Mona 1987- verfasserin (DE-588)103170437X (DE-627)737155388 (DE-576)379407442 aut Right and left heart function in lowlanders with COPD at altitude Data from a Randomized Study Mona Lichtblau, Tsogyal D. Latshang, Michael Furian, Séverine Müller-Mottet, Silke Küest, Felix Tanner, Ekkehard Grünig, Konrad E. Bloch, Silvia Ulrich February 2019 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 27.06.2019 <b><i>Background:</i></b> Changes in pulmonary hemodynamics and cardiac function in patients with chronic obstructive pulmonary disease (COPD) traveling to altitude have not been assessed despite an increasing prevalence of the disease. <b><i>Objectives:</i></b> We hypothesized that pulmonary artery pressure (PAP) significantly increases and cardiac function deteriorates during exposure to hypobaric hypoxia as encountered by traveling to moderate altitude or air flight. <b><i>Methods:</i></b> A total of 37 patients (17 female; median age [quartiles] 66 years [60; 69] with COPD GOLD grade 2-3 [FEV<sub>1</sub> 57% predicted (49; 71)]) living < 800 m underwent echocardiography in Zurich (490 m) and after 1 night at Davos Jakobshorn (2,590 m) in a randomized order of allocation. <b><i>Results:</i></b> The transtricuspid pressure gradient increased from 23 mm Hg (18; 29) to 32 mm Hg (25; 41) (<i>p</i> < 0.0001; Δmedian [95% CI] 7.5 [2.0; 13.0]), the right ventricular fractional area change decreased from 45% (39; 49) to 38% (33; 43) (<i>p</i> = 0.002), while the heart rate and systolic blood pressure increased from 70 bpm (64; 78) to 82 bpm (70; 86) (<i>p</i> < 0.0001) and from 133 mm Hg (123; 141) to 136 mm Hg (126; 148) (<i>p</i> = 0.002), respectively, and left ventricular diastolic dysfunction was more prevalent (24-54%, <i>p</i> = 0.02). <b><i>Conclusions:</i></b> This is a first study assessing changes in pulmonary hemodynamics and cardiac function in patients with COPD during a short altitude sojourn. Despite the increase in PAP and indications of change in cardiac function, the exposure was well tolerated. None of the patients had to descend to lower altitude for symptomatic altitude-related disease. Latshang, Tsogyal D. verfasserin aut Furian, Michael verfasserin aut Müller-Mottet, Séverine verfasserin aut Küest, Silke verfasserin aut Tanner, Felix verfasserin aut Grünig, Ekkehard verfasserin (DE-588)112535801 (DE-627)618892605 (DE-576)31856694X aut Bloch, Konrad E. verfasserin aut Ulrich, Silvia verfasserin aut Enthalten in Respiration Basel : Karger, 1944 97(2019), 2, Seite 125-134 Online-Ressource (DE-627)26551035X (DE-600)1464419-8 (DE-576)112815111 1423-0356 nnns volume:97 year:2019 number:2 pages:125-134 extent:10 https://doi.org/10.1159/000492898 Verlag Resolving-System Volltext https://www.karger.com/Article/FullText/492898 Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2414 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4753 AR 97 2019 2 125-134 10 2013 01 DE-16-250 3490055713 00 --%%-- --%%-- --%%-- --%%-- l01 27-06-19 2013 01 DE-16-250 00 s hd2019 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_9 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1448671612 Grünig, Ekkehard 2013 01 DE-16-250 04 k (DE-627)1444845233 Thoraxklinik Heidelberg gGmbH 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_7
allfieldsSound	10.1159/000492898 doi (DE-627)1668062364 (DE-599)KXP1668062364 (OCoLC)1341230170 DE-627 ger DE-627 rda eng Lichtblau, Mona 1987- verfasserin (DE-588)103170437X (DE-627)737155388 (DE-576)379407442 aut Right and left heart function in lowlanders with COPD at altitude Data from a Randomized Study Mona Lichtblau, Tsogyal D. Latshang, Michael Furian, Séverine Müller-Mottet, Silke Küest, Felix Tanner, Ekkehard Grünig, Konrad E. Bloch, Silvia Ulrich February 2019 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 27.06.2019 <b><i>Background:</i></b> Changes in pulmonary hemodynamics and cardiac function in patients with chronic obstructive pulmonary disease (COPD) traveling to altitude have not been assessed despite an increasing prevalence of the disease. <b><i>Objectives:</i></b> We hypothesized that pulmonary artery pressure (PAP) significantly increases and cardiac function deteriorates during exposure to hypobaric hypoxia as encountered by traveling to moderate altitude or air flight. <b><i>Methods:</i></b> A total of 37 patients (17 female; median age [quartiles] 66 years [60; 69] with COPD GOLD grade 2-3 [FEV<sub>1</sub> 57% predicted (49; 71)]) living < 800 m underwent echocardiography in Zurich (490 m) and after 1 night at Davos Jakobshorn (2,590 m) in a randomized order of allocation. <b><i>Results:</i></b> The transtricuspid pressure gradient increased from 23 mm Hg (18; 29) to 32 mm Hg (25; 41) (<i>p</i> < 0.0001; Δmedian [95% CI] 7.5 [2.0; 13.0]), the right ventricular fractional area change decreased from 45% (39; 49) to 38% (33; 43) (<i>p</i> = 0.002), while the heart rate and systolic blood pressure increased from 70 bpm (64; 78) to 82 bpm (70; 86) (<i>p</i> < 0.0001) and from 133 mm Hg (123; 141) to 136 mm Hg (126; 148) (<i>p</i> = 0.002), respectively, and left ventricular diastolic dysfunction was more prevalent (24-54%, <i>p</i> = 0.02). <b><i>Conclusions:</i></b> This is a first study assessing changes in pulmonary hemodynamics and cardiac function in patients with COPD during a short altitude sojourn. Despite the increase in PAP and indications of change in cardiac function, the exposure was well tolerated. None of the patients had to descend to lower altitude for symptomatic altitude-related disease. Latshang, Tsogyal D. verfasserin aut Furian, Michael verfasserin aut Müller-Mottet, Séverine verfasserin aut Küest, Silke verfasserin aut Tanner, Felix verfasserin aut Grünig, Ekkehard verfasserin (DE-588)112535801 (DE-627)618892605 (DE-576)31856694X aut Bloch, Konrad E. verfasserin aut Ulrich, Silvia verfasserin aut Enthalten in Respiration Basel : Karger, 1944 97(2019), 2, Seite 125-134 Online-Ressource (DE-627)26551035X (DE-600)1464419-8 (DE-576)112815111 1423-0356 nnns volume:97 year:2019 number:2 pages:125-134 extent:10 https://doi.org/10.1159/000492898 Verlag Resolving-System Volltext https://www.karger.com/Article/FullText/492898 Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2414 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4753 AR 97 2019 2 125-134 10 2013 01 DE-16-250 3490055713 00 --%%-- --%%-- --%%-- --%%-- l01 27-06-19 2013 01 DE-16-250 00 s hd2019 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_9 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1448671612 Grünig, Ekkehard 2013 01 DE-16-250 04 k (DE-627)1444845233 Thoraxklinik Heidelberg gGmbH 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_7
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source	Enthalten in Respiration 97(2019), 2, Seite 125-134 volume:97 year:2019 number:2 pages:125-134 extent:10
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container_title	Respiration
authorswithroles_txt_mv	Lichtblau, Mona @@aut@@ Latshang, Tsogyal D. @@aut@@ Furian, Michael @@aut@@ Müller-Mottet, Séverine @@aut@@ Küest, Silke @@aut@@ Tanner, Felix @@aut@@ Grünig, Ekkehard @@aut@@ Bloch, Konrad E. @@aut@@ Ulrich, Silvia @@aut@@
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Latshang, Michael Furian, Séverine Müller-Mottet, Silke Küest, Felix Tanner, Ekkehard Grünig, Konrad E. Bloch, Silvia Ulrich</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">February 2019</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">10</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Gesehen am 27.06.2019</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a"><b><i>Background:</i></b> Changes in pulmonary hemodynamics and cardiac function in patients with chronic obstructive pulmonary disease (COPD) traveling to altitude have not been assessed despite an increasing prevalence of the disease. <b><i>Objectives:</i></b> We hypothesized that pulmonary artery pressure (PAP) significantly increases and cardiac function deteriorates during exposure to hypobaric hypoxia as encountered by traveling to moderate altitude or air flight. <b><i>Methods:</i></b> A total of 37 patients (17 female; median age [quartiles] 66 years [60; 69] with COPD GOLD grade 2-3 [FEV<sub>1</sub> 57% predicted (49; 71)]) living &#x3c; 800 m underwent echocardiography in Zurich (490 m) and after 1 night at Davos Jakobshorn (2,590 m) in a randomized order of allocation. <b><i>Results:</i></b> The transtricuspid pressure gradient increased from 23 mm Hg (18; 29) to 32 mm Hg (25; 41) (<i>p</i> &#x3c; 0.0001; Δmedian [95% CI] 7.5 [2.0; 13.0]), the right ventricular fractional area change decreased from 45% (39; 49) to 38% (33; 43) (<i>p</i> = 0.002), while the heart rate and systolic blood pressure increased from 70 bpm (64; 78) to 82 bpm (70; 86) (<i>p</i> &#x3c; 0.0001) and from 133 mm Hg (123; 141) to 136 mm Hg (126; 148) (<i>p</i> = 0.002), respectively, and left ventricular diastolic dysfunction was more prevalent (24-54%, <i>p</i> = 0.02). <b><i>Conclusions:</i></b> This is a first study assessing changes in pulmonary hemodynamics and cardiac function in patients with COPD during a short altitude sojourn. 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title	Right and left heart function in lowlanders with COPD at altitude Data from a Randomized Study
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title_full	Right and left heart function in lowlanders with COPD at altitude Data from a Randomized Study Mona Lichtblau, Tsogyal D. Latshang, Michael Furian, Séverine Müller-Mottet, Silke Küest, Felix Tanner, Ekkehard Grünig, Konrad E. Bloch, Silvia Ulrich
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title_sub	Data from a Randomized Study
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title_sort	right and left heart function in lowlanders with copd at altitudedata from a randomized study
title_auth	Right and left heart function in lowlanders with COPD at altitude Data from a Randomized Study
abstract	<b><i>Background:</i></b> Changes in pulmonary hemodynamics and cardiac function in patients with chronic obstructive pulmonary disease (COPD) traveling to altitude have not been assessed despite an increasing prevalence of the disease. <b><i>Objectives:</i></b> We hypothesized that pulmonary artery pressure (PAP) significantly increases and cardiac function deteriorates during exposure to hypobaric hypoxia as encountered by traveling to moderate altitude or air flight. <b><i>Methods:</i></b> A total of 37 patients (17 female; median age [quartiles] 66 years [60; 69] with COPD GOLD grade 2-3 [FEV<sub>1</sub> 57% predicted (49; 71)]) living < 800 m underwent echocardiography in Zurich (490 m) and after 1 night at Davos Jakobshorn (2,590 m) in a randomized order of allocation. <b><i>Results:</i></b> The transtricuspid pressure gradient increased from 23 mm Hg (18; 29) to 32 mm Hg (25; 41) (<i>p</i> < 0.0001; Δmedian [95% CI] 7.5 [2.0; 13.0]), the right ventricular fractional area change decreased from 45% (39; 49) to 38% (33; 43) (<i>p</i> = 0.002), while the heart rate and systolic blood pressure increased from 70 bpm (64; 78) to 82 bpm (70; 86) (<i>p</i> < 0.0001) and from 133 mm Hg (123; 141) to 136 mm Hg (126; 148) (<i>p</i> = 0.002), respectively, and left ventricular diastolic dysfunction was more prevalent (24-54%, <i>p</i> = 0.02). <b><i>Conclusions:</i></b> This is a first study assessing changes in pulmonary hemodynamics and cardiac function in patients with COPD during a short altitude sojourn. Despite the increase in PAP and indications of change in cardiac function, the exposure was well tolerated. None of the patients had to descend to lower altitude for symptomatic altitude-related disease. Gesehen am 27.06.2019
abstractGer	<b><i>Background:</i></b> Changes in pulmonary hemodynamics and cardiac function in patients with chronic obstructive pulmonary disease (COPD) traveling to altitude have not been assessed despite an increasing prevalence of the disease. <b><i>Objectives:</i></b> We hypothesized that pulmonary artery pressure (PAP) significantly increases and cardiac function deteriorates during exposure to hypobaric hypoxia as encountered by traveling to moderate altitude or air flight. <b><i>Methods:</i></b> A total of 37 patients (17 female; median age [quartiles] 66 years [60; 69] with COPD GOLD grade 2-3 [FEV<sub>1</sub> 57% predicted (49; 71)]) living < 800 m underwent echocardiography in Zurich (490 m) and after 1 night at Davos Jakobshorn (2,590 m) in a randomized order of allocation. <b><i>Results:</i></b> The transtricuspid pressure gradient increased from 23 mm Hg (18; 29) to 32 mm Hg (25; 41) (<i>p</i> < 0.0001; Δmedian [95% CI] 7.5 [2.0; 13.0]), the right ventricular fractional area change decreased from 45% (39; 49) to 38% (33; 43) (<i>p</i> = 0.002), while the heart rate and systolic blood pressure increased from 70 bpm (64; 78) to 82 bpm (70; 86) (<i>p</i> < 0.0001) and from 133 mm Hg (123; 141) to 136 mm Hg (126; 148) (<i>p</i> = 0.002), respectively, and left ventricular diastolic dysfunction was more prevalent (24-54%, <i>p</i> = 0.02). <b><i>Conclusions:</i></b> This is a first study assessing changes in pulmonary hemodynamics and cardiac function in patients with COPD during a short altitude sojourn. Despite the increase in PAP and indications of change in cardiac function, the exposure was well tolerated. None of the patients had to descend to lower altitude for symptomatic altitude-related disease. Gesehen am 27.06.2019
abstract_unstemmed	<b><i>Background:</i></b> Changes in pulmonary hemodynamics and cardiac function in patients with chronic obstructive pulmonary disease (COPD) traveling to altitude have not been assessed despite an increasing prevalence of the disease. <b><i>Objectives:</i></b> We hypothesized that pulmonary artery pressure (PAP) significantly increases and cardiac function deteriorates during exposure to hypobaric hypoxia as encountered by traveling to moderate altitude or air flight. <b><i>Methods:</i></b> A total of 37 patients (17 female; median age [quartiles] 66 years [60; 69] with COPD GOLD grade 2-3 [FEV<sub>1</sub> 57% predicted (49; 71)]) living < 800 m underwent echocardiography in Zurich (490 m) and after 1 night at Davos Jakobshorn (2,590 m) in a randomized order of allocation. <b><i>Results:</i></b> The transtricuspid pressure gradient increased from 23 mm Hg (18; 29) to 32 mm Hg (25; 41) (<i>p</i> < 0.0001; Δmedian [95% CI] 7.5 [2.0; 13.0]), the right ventricular fractional area change decreased from 45% (39; 49) to 38% (33; 43) (<i>p</i> = 0.002), while the heart rate and systolic blood pressure increased from 70 bpm (64; 78) to 82 bpm (70; 86) (<i>p</i> < 0.0001) and from 133 mm Hg (123; 141) to 136 mm Hg (126; 148) (<i>p</i> = 0.002), respectively, and left ventricular diastolic dysfunction was more prevalent (24-54%, <i>p</i> = 0.02). <b><i>Conclusions:</i></b> This is a first study assessing changes in pulmonary hemodynamics and cardiac function in patients with COPD during a short altitude sojourn. Despite the increase in PAP and indications of change in cardiac function, the exposure was well tolerated. None of the patients had to descend to lower altitude for symptomatic altitude-related disease. Gesehen am 27.06.2019
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container_issue	2
title_short	Right and left heart function in lowlanders with COPD at altitude
url	https://doi.org/10.1159/000492898 https://www.karger.com/Article/FullText/492898
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author2	Latshang, Tsogyal D. Furian, Michael Müller-Mottet, Séverine Küest, Silke Tanner, Felix Grünig, Ekkehard Bloch, Konrad E. Ulrich, Silvia
author2Str	Latshang, Tsogyal D. Furian, Michael Müller-Mottet, Séverine Küest, Silke Tanner, Felix Grünig, Ekkehard Bloch, Konrad E. Ulrich, Silvia
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doi_str	10.1159/000492898
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up_date	2024-07-04T15:00:58.485Z
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