rRNA and tRNA bridges to neuronal homeostasis in health and disease

Dysregulation of protein translation is emerging as a unifying mechanism in the pathogenesis of many neuronal disorders. Ribosomal RNA (rRNA) and transfer RNA (tRNA) are structural molecules that have complementary and coordinated functions in protein synthesis. Defects in both rRNAs and tRNAs have...
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Autor*in:	Tuorto, Francesca [verfasserIn] Parlato, Rosanna - 1973- [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	12 March 2019

Schlagwörter:	cellular stress neurological disorders protein synthesis rRNA tRNA

Anmerkung:	Gesehen am 27.03.2020
Umfang:	17

Übergeordnetes Werk:	Enthalten in: Journal of molecular biology - Amsterdam [u.a.] : Elsevier, 1959, 431(2019), 9, Seite 1763-1779
Übergeordnetes Werk:	volume:431 ; year:2019 ; number:9 ; pages:1763-1779 ; extent:17

Links:	Volltext Volltext

DOI / URN:	10.1016/j.jmb.2019.03.004

Katalog-ID:	1693130920

Internformat


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912			\|a GBV_ILN_32
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
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912			\|a GBV_ILN_702
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
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912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
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912			\|a GBV_ILN_4305
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912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
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oclc_num	1341310883
hierarchy_sort_str	12 March 2019
publishDate	2019
allfields	10.1016/j.jmb.2019.03.004 doi (DE-627)1693130920 (DE-599)KXP1693130920 (OCoLC)1341310883 DE-627 ger DE-627 rda eng Tuorto, Francesca verfasserin (DE-588)1122208154 (DE-627)875231187 (DE-576)481189092 aut rRNA and tRNA bridges to neuronal homeostasis in health and disease Francesca Tuorto and Rosanna Parlato 12 March 2019 17 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 27.03.2020 Dysregulation of protein translation is emerging as a unifying mechanism in the pathogenesis of many neuronal disorders. Ribosomal RNA (rRNA) and transfer RNA (tRNA) are structural molecules that have complementary and coordinated functions in protein synthesis. Defects in both rRNAs and tRNAs have been described in mammalian brain development, neurological syndromes, and neurodegeneration. In this review, we present the molecular mechanisms that link aberrant rRNA and tRNA transcription, processing and modifications to translation deficits, and neuropathogenesis. We also discuss the interdependence of rRNA and tRNA biosynthesis and how their metabolism brings together proteotoxic stress and impaired neuronal homeostasis. cellular stress neurological disorders protein synthesis rRNA tRNA Parlato, Rosanna 1973- verfasserin (DE-588)1064026451 (DE-627)812875338 (DE-576)415235642 aut Enthalten in Journal of molecular biology Amsterdam [u.a.] : Elsevier, 1959 431(2019), 9, Seite 1763-1779 Online-Ressource (DE-627)222605472 (DE-600)1355192-9 (DE-576)094059837 1089-8638 nnns volume:431 year:2019 number:9 pages:1763-1779 extent:17 https://doi.org/10.1016/j.jmb.2019.03.004 Verlag Resolving-System lizenzpflichtig Volltext http://www.sciencedirect.com/science/article/pii/S0022283619301226 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 431 2019 9 1763-1779 17 2013 01 DE-16-250 3611954160 00 --%%-- --%%-- --%%-- --%%-- l01 23-03-20 2013 01 DE-16-250 00 s hd2019 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_2 2013 01 DE-16-250 03 s s_17 2013 01 DE-16-250 04 p (DE-627)1551209373 Tuorto, Francesca 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1493569007 Parlato, Rosanna 2013 01 DE-16-250 05 k (DE-627)1416822720 Extern 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2
spelling	10.1016/j.jmb.2019.03.004 doi (DE-627)1693130920 (DE-599)KXP1693130920 (OCoLC)1341310883 DE-627 ger DE-627 rda eng Tuorto, Francesca verfasserin (DE-588)1122208154 (DE-627)875231187 (DE-576)481189092 aut rRNA and tRNA bridges to neuronal homeostasis in health and disease Francesca Tuorto and Rosanna Parlato 12 March 2019 17 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 27.03.2020 Dysregulation of protein translation is emerging as a unifying mechanism in the pathogenesis of many neuronal disorders. Ribosomal RNA (rRNA) and transfer RNA (tRNA) are structural molecules that have complementary and coordinated functions in protein synthesis. Defects in both rRNAs and tRNAs have been described in mammalian brain development, neurological syndromes, and neurodegeneration. In this review, we present the molecular mechanisms that link aberrant rRNA and tRNA transcription, processing and modifications to translation deficits, and neuropathogenesis. We also discuss the interdependence of rRNA and tRNA biosynthesis and how their metabolism brings together proteotoxic stress and impaired neuronal homeostasis. cellular stress neurological disorders protein synthesis rRNA tRNA Parlato, Rosanna 1973- verfasserin (DE-588)1064026451 (DE-627)812875338 (DE-576)415235642 aut Enthalten in Journal of molecular biology Amsterdam [u.a.] : Elsevier, 1959 431(2019), 9, Seite 1763-1779 Online-Ressource (DE-627)222605472 (DE-600)1355192-9 (DE-576)094059837 1089-8638 nnns volume:431 year:2019 number:9 pages:1763-1779 extent:17 https://doi.org/10.1016/j.jmb.2019.03.004 Verlag Resolving-System lizenzpflichtig Volltext http://www.sciencedirect.com/science/article/pii/S0022283619301226 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 431 2019 9 1763-1779 17 2013 01 DE-16-250 3611954160 00 --%%-- --%%-- --%%-- --%%-- l01 23-03-20 2013 01 DE-16-250 00 s hd2019 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_2 2013 01 DE-16-250 03 s s_17 2013 01 DE-16-250 04 p (DE-627)1551209373 Tuorto, Francesca 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1493569007 Parlato, Rosanna 2013 01 DE-16-250 05 k (DE-627)1416822720 Extern 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2
allfields_unstemmed	10.1016/j.jmb.2019.03.004 doi (DE-627)1693130920 (DE-599)KXP1693130920 (OCoLC)1341310883 DE-627 ger DE-627 rda eng Tuorto, Francesca verfasserin (DE-588)1122208154 (DE-627)875231187 (DE-576)481189092 aut rRNA and tRNA bridges to neuronal homeostasis in health and disease Francesca Tuorto and Rosanna Parlato 12 March 2019 17 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 27.03.2020 Dysregulation of protein translation is emerging as a unifying mechanism in the pathogenesis of many neuronal disorders. Ribosomal RNA (rRNA) and transfer RNA (tRNA) are structural molecules that have complementary and coordinated functions in protein synthesis. Defects in both rRNAs and tRNAs have been described in mammalian brain development, neurological syndromes, and neurodegeneration. In this review, we present the molecular mechanisms that link aberrant rRNA and tRNA transcription, processing and modifications to translation deficits, and neuropathogenesis. We also discuss the interdependence of rRNA and tRNA biosynthesis and how their metabolism brings together proteotoxic stress and impaired neuronal homeostasis. cellular stress neurological disorders protein synthesis rRNA tRNA Parlato, Rosanna 1973- verfasserin (DE-588)1064026451 (DE-627)812875338 (DE-576)415235642 aut Enthalten in Journal of molecular biology Amsterdam [u.a.] : Elsevier, 1959 431(2019), 9, Seite 1763-1779 Online-Ressource (DE-627)222605472 (DE-600)1355192-9 (DE-576)094059837 1089-8638 nnns volume:431 year:2019 number:9 pages:1763-1779 extent:17 https://doi.org/10.1016/j.jmb.2019.03.004 Verlag Resolving-System lizenzpflichtig Volltext http://www.sciencedirect.com/science/article/pii/S0022283619301226 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 431 2019 9 1763-1779 17 2013 01 DE-16-250 3611954160 00 --%%-- --%%-- --%%-- --%%-- l01 23-03-20 2013 01 DE-16-250 00 s hd2019 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_2 2013 01 DE-16-250 03 s s_17 2013 01 DE-16-250 04 p (DE-627)1551209373 Tuorto, Francesca 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1493569007 Parlato, Rosanna 2013 01 DE-16-250 05 k (DE-627)1416822720 Extern 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2
allfieldsGer	10.1016/j.jmb.2019.03.004 doi (DE-627)1693130920 (DE-599)KXP1693130920 (OCoLC)1341310883 DE-627 ger DE-627 rda eng Tuorto, Francesca verfasserin (DE-588)1122208154 (DE-627)875231187 (DE-576)481189092 aut rRNA and tRNA bridges to neuronal homeostasis in health and disease Francesca Tuorto and Rosanna Parlato 12 March 2019 17 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 27.03.2020 Dysregulation of protein translation is emerging as a unifying mechanism in the pathogenesis of many neuronal disorders. Ribosomal RNA (rRNA) and transfer RNA (tRNA) are structural molecules that have complementary and coordinated functions in protein synthesis. Defects in both rRNAs and tRNAs have been described in mammalian brain development, neurological syndromes, and neurodegeneration. In this review, we present the molecular mechanisms that link aberrant rRNA and tRNA transcription, processing and modifications to translation deficits, and neuropathogenesis. We also discuss the interdependence of rRNA and tRNA biosynthesis and how their metabolism brings together proteotoxic stress and impaired neuronal homeostasis. cellular stress neurological disorders protein synthesis rRNA tRNA Parlato, Rosanna 1973- verfasserin (DE-588)1064026451 (DE-627)812875338 (DE-576)415235642 aut Enthalten in Journal of molecular biology Amsterdam [u.a.] : Elsevier, 1959 431(2019), 9, Seite 1763-1779 Online-Ressource (DE-627)222605472 (DE-600)1355192-9 (DE-576)094059837 1089-8638 nnns volume:431 year:2019 number:9 pages:1763-1779 extent:17 https://doi.org/10.1016/j.jmb.2019.03.004 Verlag Resolving-System lizenzpflichtig Volltext http://www.sciencedirect.com/science/article/pii/S0022283619301226 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 431 2019 9 1763-1779 17 2013 01 DE-16-250 3611954160 00 --%%-- --%%-- --%%-- --%%-- l01 23-03-20 2013 01 DE-16-250 00 s hd2019 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_2 2013 01 DE-16-250 03 s s_17 2013 01 DE-16-250 04 p (DE-627)1551209373 Tuorto, Francesca 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1493569007 Parlato, Rosanna 2013 01 DE-16-250 05 k (DE-627)1416822720 Extern 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2
allfieldsSound	10.1016/j.jmb.2019.03.004 doi (DE-627)1693130920 (DE-599)KXP1693130920 (OCoLC)1341310883 DE-627 ger DE-627 rda eng Tuorto, Francesca verfasserin (DE-588)1122208154 (DE-627)875231187 (DE-576)481189092 aut rRNA and tRNA bridges to neuronal homeostasis in health and disease Francesca Tuorto and Rosanna Parlato 12 March 2019 17 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 27.03.2020 Dysregulation of protein translation is emerging as a unifying mechanism in the pathogenesis of many neuronal disorders. Ribosomal RNA (rRNA) and transfer RNA (tRNA) are structural molecules that have complementary and coordinated functions in protein synthesis. Defects in both rRNAs and tRNAs have been described in mammalian brain development, neurological syndromes, and neurodegeneration. In this review, we present the molecular mechanisms that link aberrant rRNA and tRNA transcription, processing and modifications to translation deficits, and neuropathogenesis. We also discuss the interdependence of rRNA and tRNA biosynthesis and how their metabolism brings together proteotoxic stress and impaired neuronal homeostasis. cellular stress neurological disorders protein synthesis rRNA tRNA Parlato, Rosanna 1973- verfasserin (DE-588)1064026451 (DE-627)812875338 (DE-576)415235642 aut Enthalten in Journal of molecular biology Amsterdam [u.a.] : Elsevier, 1959 431(2019), 9, Seite 1763-1779 Online-Ressource (DE-627)222605472 (DE-600)1355192-9 (DE-576)094059837 1089-8638 nnns volume:431 year:2019 number:9 pages:1763-1779 extent:17 https://doi.org/10.1016/j.jmb.2019.03.004 Verlag Resolving-System lizenzpflichtig Volltext http://www.sciencedirect.com/science/article/pii/S0022283619301226 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 431 2019 9 1763-1779 17 2013 01 DE-16-250 3611954160 00 --%%-- --%%-- --%%-- --%%-- l01 23-03-20 2013 01 DE-16-250 00 s hd2019 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_2 2013 01 DE-16-250 03 s s_17 2013 01 DE-16-250 04 p (DE-627)1551209373 Tuorto, Francesca 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1493569007 Parlato, Rosanna 2013 01 DE-16-250 05 k (DE-627)1416822720 Extern 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2
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source	Enthalten in Journal of molecular biology 431(2019), 9, Seite 1763-1779 volume:431 year:2019 number:9 pages:1763-1779 extent:17
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topic_facet	cellular stress neurological disorders protein synthesis rRNA tRNA
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title	rRNA and tRNA bridges to neuronal homeostasis in health and disease
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title_full	rRNA and tRNA bridges to neuronal homeostasis in health and disease Francesca Tuorto and Rosanna Parlato
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title_sort	rrna and trna bridges to neuronal homeostasis in health and disease
title_auth	rRNA and tRNA bridges to neuronal homeostasis in health and disease
abstract	Dysregulation of protein translation is emerging as a unifying mechanism in the pathogenesis of many neuronal disorders. Ribosomal RNA (rRNA) and transfer RNA (tRNA) are structural molecules that have complementary and coordinated functions in protein synthesis. Defects in both rRNAs and tRNAs have been described in mammalian brain development, neurological syndromes, and neurodegeneration. In this review, we present the molecular mechanisms that link aberrant rRNA and tRNA transcription, processing and modifications to translation deficits, and neuropathogenesis. We also discuss the interdependence of rRNA and tRNA biosynthesis and how their metabolism brings together proteotoxic stress and impaired neuronal homeostasis. Gesehen am 27.03.2020
abstractGer	Dysregulation of protein translation is emerging as a unifying mechanism in the pathogenesis of many neuronal disorders. Ribosomal RNA (rRNA) and transfer RNA (tRNA) are structural molecules that have complementary and coordinated functions in protein synthesis. Defects in both rRNAs and tRNAs have been described in mammalian brain development, neurological syndromes, and neurodegeneration. In this review, we present the molecular mechanisms that link aberrant rRNA and tRNA transcription, processing and modifications to translation deficits, and neuropathogenesis. We also discuss the interdependence of rRNA and tRNA biosynthesis and how their metabolism brings together proteotoxic stress and impaired neuronal homeostasis. Gesehen am 27.03.2020
abstract_unstemmed	Dysregulation of protein translation is emerging as a unifying mechanism in the pathogenesis of many neuronal disorders. Ribosomal RNA (rRNA) and transfer RNA (tRNA) are structural molecules that have complementary and coordinated functions in protein synthesis. Defects in both rRNAs and tRNAs have been described in mammalian brain development, neurological syndromes, and neurodegeneration. In this review, we present the molecular mechanisms that link aberrant rRNA and tRNA transcription, processing and modifications to translation deficits, and neuropathogenesis. We also discuss the interdependence of rRNA and tRNA biosynthesis and how their metabolism brings together proteotoxic stress and impaired neuronal homeostasis. Gesehen am 27.03.2020
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title_short	rRNA and tRNA bridges to neuronal homeostasis in health and disease
url	https://doi.org/10.1016/j.jmb.2019.03.004 http://www.sciencedirect.com/science/article/pii/S0022283619301226
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rRNA and tRNA bridges to neuronal homeostasis in health and disease

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