Autologous hematopoietic stem cell transplantation for relapsed/refractory systemic anaplastic large cell lymphoma : a retrospective analysis of the lymphoma working party (LWP) of the EBMT
Systemic anaplastic large cell lymphoma (sALCL) is a rare histological entity expressing the CD30 antigen that comprises around 11% of peripheral T-cell lymphoma. We analysed the outcome of patients with relapsed/refractory sALCL treated with autologous stem cell transplantation (auto-HCT). We inclu...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Domingo-Domènech, Eva [verfasserIn] Boumendil, A. [verfasserIn] Climent, F. [verfasserIn] Sengeloev, H. [verfasserIn] Wahlin, B. [verfasserIn] Wattad, W. [verfasserIn] Arat, M. [verfasserIn] Finel, H. [verfasserIn] Schapp, N. [verfasserIn] Ganser, A. [verfasserIn] Yeshurun, M. [verfasserIn] Pavone, V. [verfasserIn] Snowden, J. [verfasserIn] Finke, J. [verfasserIn] Montoto, S. [verfasserIn] Sureda, A. [verfasserIn] Dreger, Peter [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Anmerkung: |
Published online: 6 November 2019 Gesehen am 21.04.2020 |
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| Umfang: |
8 |
| Übergeordnetes Werk: |
Enthalten in: Bone marrow transplantation - London : Springer Nature, 1997, 55(2020), 4, Seite 796-803 |
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| Übergeordnetes Werk: |
volume:55 ; year:2020 ; number:4 ; pages:796-803 ; extent:8 |
| Links: |
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| DOI / URN: |
10.1038/s41409-019-0734-7 |
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| Katalog-ID: |
169526925X |
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| 245 | 1 | 0 | |a Autologous hematopoietic stem cell transplantation for relapsed/refractory systemic anaplastic large cell lymphoma |b a retrospective analysis of the lymphoma working party (LWP) of the EBMT |c E. Domingo-Domènech, A. Boumendil, F. Climent, H. Sengeloev, B. Wahlin, W. Wattad, M. Arat, H. Finel, N. Schapp, A. Ganser, M. Yeshurun, V. Pavone, J. Snowden, J. Finke, S. Montoto, A. Sureda, P. Dreger |
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| 520 | |a Systemic anaplastic large cell lymphoma (sALCL) is a rare histological entity expressing the CD30 antigen that comprises around 11% of peripheral T-cell lymphoma. We analysed the outcome of patients with relapsed/refractory sALCL treated with autologous stem cell transplantation (auto-HCT). We included 65 adult patients (42 males; median age, 44 years); 24 patients had an ALK-ve sALCL. Fifty-one patients had chemosensitive disease at the time of transplant. Ten patients (15%) were treated with brentuximab vedotin (BV) before auto-HCT (median number of doses: 5). The median follow-up for surviving patients was 35 months (3-71). Three-year cumulative incidence of nonrelapse mortality and of relapse were 1.7% and 34%, respectively. Three-year progression-free survival and overall survival were 64% and 73%, respectively. No prognostic factors for any of the outcomes analysed were found in univariate analysis. There were no significant differences in any of the outcomes between patients who had received BV and the remainder. This is the largest analysis presented so far analysing the role of auto-HCT in patients with relapsed/refractory sALCL, showing a promising PFS and OS in this high-risk population. The potential impact of the administration of BV as salvage strategy before the procedure needs to be further elucidated. | ||
| 534 | |c 2019 | ||
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| 700 | 1 | |a Climent, F. |e verfasserin |4 aut | |
| 700 | 1 | |a Sengeloev, H. |e verfasserin |4 aut | |
| 700 | 1 | |a Wahlin, B. |e verfasserin |4 aut | |
| 700 | 1 | |a Wattad, W. |e verfasserin |4 aut | |
| 700 | 1 | |a Arat, M. |e verfasserin |4 aut | |
| 700 | 1 | |a Finel, H. |e verfasserin |4 aut | |
| 700 | 1 | |a Schapp, N. |e verfasserin |4 aut | |
| 700 | 1 | |a Ganser, A. |e verfasserin |4 aut | |
| 700 | 1 | |a Yeshurun, M. |e verfasserin |4 aut | |
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| 700 | 1 | |a Montoto, S. |e verfasserin |4 aut | |
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10.1038/s41409-019-0734-7 doi (DE-627)169526925X (DE-599)KXP169526925X (OCoLC)1341315980 DE-627 ger DE-627 rda eng Domingo-Domènech, Eva verfasserin (DE-588)1208420607 (DE-627)169467777X aut Autologous hematopoietic stem cell transplantation for relapsed/refractory systemic anaplastic large cell lymphoma a retrospective analysis of the lymphoma working party (LWP) of the EBMT E. Domingo-Domènech, A. Boumendil, F. Climent, H. Sengeloev, B. Wahlin, W. Wattad, M. Arat, H. Finel, N. Schapp, A. Ganser, M. Yeshurun, V. Pavone, J. Snowden, J. Finke, S. Montoto, A. Sureda, P. Dreger 2020 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Published online: 6 November 2019 Gesehen am 21.04.2020 Systemic anaplastic large cell lymphoma (sALCL) is a rare histological entity expressing the CD30 antigen that comprises around 11% of peripheral T-cell lymphoma. We analysed the outcome of patients with relapsed/refractory sALCL treated with autologous stem cell transplantation (auto-HCT). We included 65 adult patients (42 males; median age, 44 years); 24 patients had an ALK-ve sALCL. Fifty-one patients had chemosensitive disease at the time of transplant. Ten patients (15%) were treated with brentuximab vedotin (BV) before auto-HCT (median number of doses: 5). The median follow-up for surviving patients was 35 months (3-71). Three-year cumulative incidence of nonrelapse mortality and of relapse were 1.7% and 34%, respectively. Three-year progression-free survival and overall survival were 64% and 73%, respectively. No prognostic factors for any of the outcomes analysed were found in univariate analysis. There were no significant differences in any of the outcomes between patients who had received BV and the remainder. This is the largest analysis presented so far analysing the role of auto-HCT in patients with relapsed/refractory sALCL, showing a promising PFS and OS in this high-risk population. The potential impact of the administration of BV as salvage strategy before the procedure needs to be further elucidated. 2019 Boumendil, A. verfasserin aut Climent, F. verfasserin aut Sengeloev, H. verfasserin aut Wahlin, B. verfasserin aut Wattad, W. verfasserin aut Arat, M. verfasserin aut Finel, H. verfasserin aut Schapp, N. verfasserin aut Ganser, A. verfasserin aut Yeshurun, M. verfasserin aut Pavone, V. verfasserin aut Snowden, J. verfasserin aut Finke, J. verfasserin aut Montoto, S. verfasserin aut Sureda, A. verfasserin aut Dreger, Peter verfasserin (DE-588)1028891881 (DE-627)732699894 (DE-576)376320966 aut Enthalten in Bone marrow transplantation London : Springer Nature, 1997 55(2020), 4, Seite 796-803 Online-Ressource (DE-627)320433366 (DE-600)2004030-1 (DE-576)091012996 1476-5365 nnns volume:55 year:2020 number:4 pages:796-803 extent:8 https://doi.org/10.1038/s41409-019-0734-7 Verlag Resolving-System lizenzpflichtig Volltext https://www.nature.com/articles/s41409-019-0734-7 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 55 2020 4 796-803 8 2013 01 DE-16-250 3627649370 00 --%%-- --%%-- --%%-- --%%-- l01 21-04-20 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_17 2013 01 DE-16-250 03 s s_8 2013 01 DE-16-250 04 p (DE-627)1447864395 Dreger, Peter 2013 01 DE-16-250 04 k (DE-627)169133667X Zentrum für Innere Medizin (Krehl Klinik) 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_17 |
| spelling |
10.1038/s41409-019-0734-7 doi (DE-627)169526925X (DE-599)KXP169526925X (OCoLC)1341315980 DE-627 ger DE-627 rda eng Domingo-Domènech, Eva verfasserin (DE-588)1208420607 (DE-627)169467777X aut Autologous hematopoietic stem cell transplantation for relapsed/refractory systemic anaplastic large cell lymphoma a retrospective analysis of the lymphoma working party (LWP) of the EBMT E. Domingo-Domènech, A. Boumendil, F. Climent, H. Sengeloev, B. Wahlin, W. Wattad, M. Arat, H. Finel, N. Schapp, A. Ganser, M. Yeshurun, V. Pavone, J. Snowden, J. Finke, S. Montoto, A. Sureda, P. Dreger 2020 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Published online: 6 November 2019 Gesehen am 21.04.2020 Systemic anaplastic large cell lymphoma (sALCL) is a rare histological entity expressing the CD30 antigen that comprises around 11% of peripheral T-cell lymphoma. We analysed the outcome of patients with relapsed/refractory sALCL treated with autologous stem cell transplantation (auto-HCT). We included 65 adult patients (42 males; median age, 44 years); 24 patients had an ALK-ve sALCL. Fifty-one patients had chemosensitive disease at the time of transplant. Ten patients (15%) were treated with brentuximab vedotin (BV) before auto-HCT (median number of doses: 5). The median follow-up for surviving patients was 35 months (3-71). Three-year cumulative incidence of nonrelapse mortality and of relapse were 1.7% and 34%, respectively. Three-year progression-free survival and overall survival were 64% and 73%, respectively. No prognostic factors for any of the outcomes analysed were found in univariate analysis. There were no significant differences in any of the outcomes between patients who had received BV and the remainder. This is the largest analysis presented so far analysing the role of auto-HCT in patients with relapsed/refractory sALCL, showing a promising PFS and OS in this high-risk population. The potential impact of the administration of BV as salvage strategy before the procedure needs to be further elucidated. 2019 Boumendil, A. verfasserin aut Climent, F. verfasserin aut Sengeloev, H. verfasserin aut Wahlin, B. verfasserin aut Wattad, W. verfasserin aut Arat, M. verfasserin aut Finel, H. verfasserin aut Schapp, N. verfasserin aut Ganser, A. verfasserin aut Yeshurun, M. verfasserin aut Pavone, V. verfasserin aut Snowden, J. verfasserin aut Finke, J. verfasserin aut Montoto, S. verfasserin aut Sureda, A. verfasserin aut Dreger, Peter verfasserin (DE-588)1028891881 (DE-627)732699894 (DE-576)376320966 aut Enthalten in Bone marrow transplantation London : Springer Nature, 1997 55(2020), 4, Seite 796-803 Online-Ressource (DE-627)320433366 (DE-600)2004030-1 (DE-576)091012996 1476-5365 nnns volume:55 year:2020 number:4 pages:796-803 extent:8 https://doi.org/10.1038/s41409-019-0734-7 Verlag Resolving-System lizenzpflichtig Volltext https://www.nature.com/articles/s41409-019-0734-7 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 55 2020 4 796-803 8 2013 01 DE-16-250 3627649370 00 --%%-- --%%-- --%%-- --%%-- l01 21-04-20 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_17 2013 01 DE-16-250 03 s s_8 2013 01 DE-16-250 04 p (DE-627)1447864395 Dreger, Peter 2013 01 DE-16-250 04 k (DE-627)169133667X Zentrum für Innere Medizin (Krehl Klinik) 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_17 |
| allfields_unstemmed |
10.1038/s41409-019-0734-7 doi (DE-627)169526925X (DE-599)KXP169526925X (OCoLC)1341315980 DE-627 ger DE-627 rda eng Domingo-Domènech, Eva verfasserin (DE-588)1208420607 (DE-627)169467777X aut Autologous hematopoietic stem cell transplantation for relapsed/refractory systemic anaplastic large cell lymphoma a retrospective analysis of the lymphoma working party (LWP) of the EBMT E. Domingo-Domènech, A. Boumendil, F. Climent, H. Sengeloev, B. Wahlin, W. Wattad, M. Arat, H. Finel, N. Schapp, A. Ganser, M. Yeshurun, V. Pavone, J. Snowden, J. Finke, S. Montoto, A. Sureda, P. Dreger 2020 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Published online: 6 November 2019 Gesehen am 21.04.2020 Systemic anaplastic large cell lymphoma (sALCL) is a rare histological entity expressing the CD30 antigen that comprises around 11% of peripheral T-cell lymphoma. We analysed the outcome of patients with relapsed/refractory sALCL treated with autologous stem cell transplantation (auto-HCT). We included 65 adult patients (42 males; median age, 44 years); 24 patients had an ALK-ve sALCL. Fifty-one patients had chemosensitive disease at the time of transplant. Ten patients (15%) were treated with brentuximab vedotin (BV) before auto-HCT (median number of doses: 5). The median follow-up for surviving patients was 35 months (3-71). Three-year cumulative incidence of nonrelapse mortality and of relapse were 1.7% and 34%, respectively. Three-year progression-free survival and overall survival were 64% and 73%, respectively. No prognostic factors for any of the outcomes analysed were found in univariate analysis. There were no significant differences in any of the outcomes between patients who had received BV and the remainder. This is the largest analysis presented so far analysing the role of auto-HCT in patients with relapsed/refractory sALCL, showing a promising PFS and OS in this high-risk population. The potential impact of the administration of BV as salvage strategy before the procedure needs to be further elucidated. 2019 Boumendil, A. verfasserin aut Climent, F. verfasserin aut Sengeloev, H. verfasserin aut Wahlin, B. verfasserin aut Wattad, W. verfasserin aut Arat, M. verfasserin aut Finel, H. verfasserin aut Schapp, N. verfasserin aut Ganser, A. verfasserin aut Yeshurun, M. verfasserin aut Pavone, V. verfasserin aut Snowden, J. verfasserin aut Finke, J. verfasserin aut Montoto, S. verfasserin aut Sureda, A. verfasserin aut Dreger, Peter verfasserin (DE-588)1028891881 (DE-627)732699894 (DE-576)376320966 aut Enthalten in Bone marrow transplantation London : Springer Nature, 1997 55(2020), 4, Seite 796-803 Online-Ressource (DE-627)320433366 (DE-600)2004030-1 (DE-576)091012996 1476-5365 nnns volume:55 year:2020 number:4 pages:796-803 extent:8 https://doi.org/10.1038/s41409-019-0734-7 Verlag Resolving-System lizenzpflichtig Volltext https://www.nature.com/articles/s41409-019-0734-7 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 55 2020 4 796-803 8 2013 01 DE-16-250 3627649370 00 --%%-- --%%-- --%%-- --%%-- l01 21-04-20 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_17 2013 01 DE-16-250 03 s s_8 2013 01 DE-16-250 04 p (DE-627)1447864395 Dreger, Peter 2013 01 DE-16-250 04 k (DE-627)169133667X Zentrum für Innere Medizin (Krehl Klinik) 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_17 |
| allfieldsGer |
10.1038/s41409-019-0734-7 doi (DE-627)169526925X (DE-599)KXP169526925X (OCoLC)1341315980 DE-627 ger DE-627 rda eng Domingo-Domènech, Eva verfasserin (DE-588)1208420607 (DE-627)169467777X aut Autologous hematopoietic stem cell transplantation for relapsed/refractory systemic anaplastic large cell lymphoma a retrospective analysis of the lymphoma working party (LWP) of the EBMT E. Domingo-Domènech, A. Boumendil, F. Climent, H. Sengeloev, B. Wahlin, W. Wattad, M. Arat, H. Finel, N. Schapp, A. Ganser, M. Yeshurun, V. Pavone, J. Snowden, J. Finke, S. Montoto, A. Sureda, P. Dreger 2020 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Published online: 6 November 2019 Gesehen am 21.04.2020 Systemic anaplastic large cell lymphoma (sALCL) is a rare histological entity expressing the CD30 antigen that comprises around 11% of peripheral T-cell lymphoma. We analysed the outcome of patients with relapsed/refractory sALCL treated with autologous stem cell transplantation (auto-HCT). We included 65 adult patients (42 males; median age, 44 years); 24 patients had an ALK-ve sALCL. Fifty-one patients had chemosensitive disease at the time of transplant. Ten patients (15%) were treated with brentuximab vedotin (BV) before auto-HCT (median number of doses: 5). The median follow-up for surviving patients was 35 months (3-71). Three-year cumulative incidence of nonrelapse mortality and of relapse were 1.7% and 34%, respectively. Three-year progression-free survival and overall survival were 64% and 73%, respectively. No prognostic factors for any of the outcomes analysed were found in univariate analysis. There were no significant differences in any of the outcomes between patients who had received BV and the remainder. This is the largest analysis presented so far analysing the role of auto-HCT in patients with relapsed/refractory sALCL, showing a promising PFS and OS in this high-risk population. The potential impact of the administration of BV as salvage strategy before the procedure needs to be further elucidated. 2019 Boumendil, A. verfasserin aut Climent, F. verfasserin aut Sengeloev, H. verfasserin aut Wahlin, B. verfasserin aut Wattad, W. verfasserin aut Arat, M. verfasserin aut Finel, H. verfasserin aut Schapp, N. verfasserin aut Ganser, A. verfasserin aut Yeshurun, M. verfasserin aut Pavone, V. verfasserin aut Snowden, J. verfasserin aut Finke, J. verfasserin aut Montoto, S. verfasserin aut Sureda, A. verfasserin aut Dreger, Peter verfasserin (DE-588)1028891881 (DE-627)732699894 (DE-576)376320966 aut Enthalten in Bone marrow transplantation London : Springer Nature, 1997 55(2020), 4, Seite 796-803 Online-Ressource (DE-627)320433366 (DE-600)2004030-1 (DE-576)091012996 1476-5365 nnns volume:55 year:2020 number:4 pages:796-803 extent:8 https://doi.org/10.1038/s41409-019-0734-7 Verlag Resolving-System lizenzpflichtig Volltext https://www.nature.com/articles/s41409-019-0734-7 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 55 2020 4 796-803 8 2013 01 DE-16-250 3627649370 00 --%%-- --%%-- --%%-- --%%-- l01 21-04-20 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_17 2013 01 DE-16-250 03 s s_8 2013 01 DE-16-250 04 p (DE-627)1447864395 Dreger, Peter 2013 01 DE-16-250 04 k (DE-627)169133667X Zentrum für Innere Medizin (Krehl Klinik) 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_17 |
| allfieldsSound |
10.1038/s41409-019-0734-7 doi (DE-627)169526925X (DE-599)KXP169526925X (OCoLC)1341315980 DE-627 ger DE-627 rda eng Domingo-Domènech, Eva verfasserin (DE-588)1208420607 (DE-627)169467777X aut Autologous hematopoietic stem cell transplantation for relapsed/refractory systemic anaplastic large cell lymphoma a retrospective analysis of the lymphoma working party (LWP) of the EBMT E. Domingo-Domènech, A. Boumendil, F. Climent, H. Sengeloev, B. Wahlin, W. Wattad, M. Arat, H. Finel, N. Schapp, A. Ganser, M. Yeshurun, V. Pavone, J. Snowden, J. Finke, S. Montoto, A. Sureda, P. Dreger 2020 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Published online: 6 November 2019 Gesehen am 21.04.2020 Systemic anaplastic large cell lymphoma (sALCL) is a rare histological entity expressing the CD30 antigen that comprises around 11% of peripheral T-cell lymphoma. We analysed the outcome of patients with relapsed/refractory sALCL treated with autologous stem cell transplantation (auto-HCT). We included 65 adult patients (42 males; median age, 44 years); 24 patients had an ALK-ve sALCL. Fifty-one patients had chemosensitive disease at the time of transplant. Ten patients (15%) were treated with brentuximab vedotin (BV) before auto-HCT (median number of doses: 5). The median follow-up for surviving patients was 35 months (3-71). Three-year cumulative incidence of nonrelapse mortality and of relapse were 1.7% and 34%, respectively. Three-year progression-free survival and overall survival were 64% and 73%, respectively. No prognostic factors for any of the outcomes analysed were found in univariate analysis. There were no significant differences in any of the outcomes between patients who had received BV and the remainder. This is the largest analysis presented so far analysing the role of auto-HCT in patients with relapsed/refractory sALCL, showing a promising PFS and OS in this high-risk population. The potential impact of the administration of BV as salvage strategy before the procedure needs to be further elucidated. 2019 Boumendil, A. verfasserin aut Climent, F. verfasserin aut Sengeloev, H. verfasserin aut Wahlin, B. verfasserin aut Wattad, W. verfasserin aut Arat, M. verfasserin aut Finel, H. verfasserin aut Schapp, N. verfasserin aut Ganser, A. verfasserin aut Yeshurun, M. verfasserin aut Pavone, V. verfasserin aut Snowden, J. verfasserin aut Finke, J. verfasserin aut Montoto, S. verfasserin aut Sureda, A. verfasserin aut Dreger, Peter verfasserin (DE-588)1028891881 (DE-627)732699894 (DE-576)376320966 aut Enthalten in Bone marrow transplantation London : Springer Nature, 1997 55(2020), 4, Seite 796-803 Online-Ressource (DE-627)320433366 (DE-600)2004030-1 (DE-576)091012996 1476-5365 nnns volume:55 year:2020 number:4 pages:796-803 extent:8 https://doi.org/10.1038/s41409-019-0734-7 Verlag Resolving-System lizenzpflichtig Volltext https://www.nature.com/articles/s41409-019-0734-7 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 55 2020 4 796-803 8 2013 01 DE-16-250 3627649370 00 --%%-- --%%-- --%%-- --%%-- l01 21-04-20 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_17 2013 01 DE-16-250 03 s s_8 2013 01 DE-16-250 04 p (DE-627)1447864395 Dreger, Peter 2013 01 DE-16-250 04 k (DE-627)169133667X Zentrum für Innere Medizin (Krehl Klinik) 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_17 |
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Domingo-Domènech, Eva @@aut@@ Boumendil, A. @@aut@@ Climent, F. @@aut@@ Sengeloev, H. @@aut@@ Wahlin, B. @@aut@@ Wattad, W. @@aut@@ Arat, M. @@aut@@ Finel, H. @@aut@@ Schapp, N. @@aut@@ Ganser, A. @@aut@@ Yeshurun, M. @@aut@@ Pavone, V. @@aut@@ Snowden, J. @@aut@@ Finke, J. @@aut@@ Montoto, S. @@aut@@ Sureda, A. @@aut@@ Dreger, Peter @@aut@@ |
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Autologous hematopoietic stem cell transplantation for relapsed/refractory systemic anaplastic large cell lymphoma a retrospective analysis of the lymphoma working party (LWP) of the EBMT |
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Autologous hematopoietic stem cell transplantation for relapsed/refractory systemic anaplastic large cell lymphoma a retrospective analysis of the lymphoma working party (LWP) of the EBMT E. Domingo-Domènech, A. Boumendil, F. Climent, H. Sengeloev, B. Wahlin, W. Wattad, M. Arat, H. Finel, N. Schapp, A. Ganser, M. Yeshurun, V. Pavone, J. Snowden, J. Finke, S. Montoto, A. Sureda, P. Dreger |
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a retrospective analysis of the lymphoma working party (LWP) of the EBMT |
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autologous hematopoietic stem cell transplantation for relapsed/refractory systemic anaplastic large cell lymphomaa retrospective analysis of the lymphoma working party (lwp) of the ebmt |
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Autologous hematopoietic stem cell transplantation for relapsed/refractory systemic anaplastic large cell lymphoma a retrospective analysis of the lymphoma working party (LWP) of the EBMT |
| abstract |
Systemic anaplastic large cell lymphoma (sALCL) is a rare histological entity expressing the CD30 antigen that comprises around 11% of peripheral T-cell lymphoma. We analysed the outcome of patients with relapsed/refractory sALCL treated with autologous stem cell transplantation (auto-HCT). We included 65 adult patients (42 males; median age, 44 years); 24 patients had an ALK-ve sALCL. Fifty-one patients had chemosensitive disease at the time of transplant. Ten patients (15%) were treated with brentuximab vedotin (BV) before auto-HCT (median number of doses: 5). The median follow-up for surviving patients was 35 months (3-71). Three-year cumulative incidence of nonrelapse mortality and of relapse were 1.7% and 34%, respectively. Three-year progression-free survival and overall survival were 64% and 73%, respectively. No prognostic factors for any of the outcomes analysed were found in univariate analysis. There were no significant differences in any of the outcomes between patients who had received BV and the remainder. This is the largest analysis presented so far analysing the role of auto-HCT in patients with relapsed/refractory sALCL, showing a promising PFS and OS in this high-risk population. The potential impact of the administration of BV as salvage strategy before the procedure needs to be further elucidated. Published online: 6 November 2019 Gesehen am 21.04.2020 |
| abstractGer |
Systemic anaplastic large cell lymphoma (sALCL) is a rare histological entity expressing the CD30 antigen that comprises around 11% of peripheral T-cell lymphoma. We analysed the outcome of patients with relapsed/refractory sALCL treated with autologous stem cell transplantation (auto-HCT). We included 65 adult patients (42 males; median age, 44 years); 24 patients had an ALK-ve sALCL. Fifty-one patients had chemosensitive disease at the time of transplant. Ten patients (15%) were treated with brentuximab vedotin (BV) before auto-HCT (median number of doses: 5). The median follow-up for surviving patients was 35 months (3-71). Three-year cumulative incidence of nonrelapse mortality and of relapse were 1.7% and 34%, respectively. Three-year progression-free survival and overall survival were 64% and 73%, respectively. No prognostic factors for any of the outcomes analysed were found in univariate analysis. There were no significant differences in any of the outcomes between patients who had received BV and the remainder. This is the largest analysis presented so far analysing the role of auto-HCT in patients with relapsed/refractory sALCL, showing a promising PFS and OS in this high-risk population. The potential impact of the administration of BV as salvage strategy before the procedure needs to be further elucidated. Published online: 6 November 2019 Gesehen am 21.04.2020 |
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Systemic anaplastic large cell lymphoma (sALCL) is a rare histological entity expressing the CD30 antigen that comprises around 11% of peripheral T-cell lymphoma. We analysed the outcome of patients with relapsed/refractory sALCL treated with autologous stem cell transplantation (auto-HCT). We included 65 adult patients (42 males; median age, 44 years); 24 patients had an ALK-ve sALCL. Fifty-one patients had chemosensitive disease at the time of transplant. Ten patients (15%) were treated with brentuximab vedotin (BV) before auto-HCT (median number of doses: 5). The median follow-up for surviving patients was 35 months (3-71). Three-year cumulative incidence of nonrelapse mortality and of relapse were 1.7% and 34%, respectively. Three-year progression-free survival and overall survival were 64% and 73%, respectively. No prognostic factors for any of the outcomes analysed were found in univariate analysis. There were no significant differences in any of the outcomes between patients who had received BV and the remainder. This is the largest analysis presented so far analysing the role of auto-HCT in patients with relapsed/refractory sALCL, showing a promising PFS and OS in this high-risk population. The potential impact of the administration of BV as salvage strategy before the procedure needs to be further elucidated. Published online: 6 November 2019 Gesehen am 21.04.2020 |
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7.398512 |