Photon vs. proton radiochemotherapy : effects on brain tissue volume and perfusion

Background and purpose - To compare the structural and hemodynamic changes of healthy brain tissue in the cerebral hemisphere contralateral to the tumor following photon and proton radiochemotherapy. - Materials and methods - Sixty-seven patients (54.9±14.0years) diagnosed with glioblastoma undergoi...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Petr, Jan [verfasserIn] Beuthien-Baumann, Bettina - 1962- [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	19 January 2018

Schlagwörter:	Arterial spin labeling Brain atrophy Cerebral blood flow Proton beam therapy Radiochemotherapy

Anmerkung:	Gesehen am 21.04.2020
Umfang:	7

Übergeordnetes Werk:	Enthalten in: Radiotherapy and oncology - Amsterdam [u.a.] : Elsevier Science, 1983, 128(2018), 1, Seite 121-127
Übergeordnetes Werk:	volume:128 ; year:2018 ; number:1 ; pages:121-127 ; extent:7

Links:	Volltext Volltext

DOI / URN:	10.1016/j.radonc.2017.11.033

Katalog-ID:	1695329260

Internformat


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245	1	0	\|a Photon vs. proton radiochemotherapy \|b effects on brain tissue volume and perfusion \|c Jan Petr, Ivan Platzek, Frank Hofheinz, Henri J. M. M. Mutsaerts, Iris Asllani, Matthias J. P. van Osch, Annekatrin Seidlitz, Pawel Krukowski, Andreas Gommlich, Bettina Beuthien-Baumann, Christina Jentsch, Jens Maus, Esther G. C. Troost, Michael Baumann, Mechthild Krause, Jörg van den Hoff
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520			\|a Background and purpose - To compare the structural and hemodynamic changes of healthy brain tissue in the cerebral hemisphere contralateral to the tumor following photon and proton radiochemotherapy. - Materials and methods - Sixty-seven patients (54.9±14.0years) diagnosed with glioblastoma undergoing adjuvant photon (n=47) or proton (n=19) radiochemotherapy with temozolomide after tumor resection underwent T1-weighted and arterial spin labeling MRI. Changes in volume and perfusion before and 3 to 6months after were compared between therapies. - Results - A decrease in gray matter (GM) (−2.2%, P<0.001) and white matter (WM) (−1.2%, P<0.001) volume was observed in photon-therapy patients compared to the pre-radiotherapy baseline. In contrast, for the proton-therapy group, no significant differences in GM (0.3%, P=0.64) or WM (−0.4%, P=0.58) volume were observed. GM volume decreased with 0.9% per 10Gy dose increase (P<0.001) and differed between the radiation modalities (P<0.001). Perfusion decreased in photon-therapy patients (−10.1%, P=0.002), whereas the decrease in proton-therapy patients, while comparable in magnitude, did not reach statistical significance (−9.1%, P=0.12). There was no correlation between perfusion decrease and either dose (P=0.64) or radiation modality (P=0.94). - Conclusions - Our results show that the tissue volume decrease depends on radiation dose delivered to the healthy hemisphere and differs between treatment modalities. In contrast, the decrease in perfusion was comparable for both irradiation modalities. We conclude that proton therapy may reduce brain-volume loss when compared to photon therapy.
650		4	\|a Arterial spin labeling
650		4	\|a Brain atrophy
650		4	\|a Cerebral blood flow
650		4	\|a Proton beam therapy
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publishDate	2018
allfields	10.1016/j.radonc.2017.11.033 doi (DE-627)1695329260 (DE-599)KXP1695329260 (OCoLC)1341315956 DE-627 ger DE-627 rda eng Petr, Jan verfasserin (DE-588)1208728598 (DE-627)1695328760 aut Photon vs. proton radiochemotherapy effects on brain tissue volume and perfusion Jan Petr, Ivan Platzek, Frank Hofheinz, Henri J. M. M. Mutsaerts, Iris Asllani, Matthias J. P. van Osch, Annekatrin Seidlitz, Pawel Krukowski, Andreas Gommlich, Bettina Beuthien-Baumann, Christina Jentsch, Jens Maus, Esther G. C. Troost, Michael Baumann, Mechthild Krause, Jörg van den Hoff Photon versus proton radiochemotherapy 19 January 2018 7 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 21.04.2020 Background and purpose - To compare the structural and hemodynamic changes of healthy brain tissue in the cerebral hemisphere contralateral to the tumor following photon and proton radiochemotherapy. - Materials and methods - Sixty-seven patients (54.9±14.0years) diagnosed with glioblastoma undergoing adjuvant photon (n=47) or proton (n=19) radiochemotherapy with temozolomide after tumor resection underwent T1-weighted and arterial spin labeling MRI. Changes in volume and perfusion before and 3 to 6months after were compared between therapies. - Results - A decrease in gray matter (GM) (−2.2%, P<0.001) and white matter (WM) (−1.2%, P<0.001) volume was observed in photon-therapy patients compared to the pre-radiotherapy baseline. In contrast, for the proton-therapy group, no significant differences in GM (0.3%, P=0.64) or WM (−0.4%, P=0.58) volume were observed. GM volume decreased with 0.9% per 10Gy dose increase (P<0.001) and differed between the radiation modalities (P<0.001). Perfusion decreased in photon-therapy patients (−10.1%, P=0.002), whereas the decrease in proton-therapy patients, while comparable in magnitude, did not reach statistical significance (−9.1%, P=0.12). There was no correlation between perfusion decrease and either dose (P=0.64) or radiation modality (P=0.94). - Conclusions - Our results show that the tissue volume decrease depends on radiation dose delivered to the healthy hemisphere and differs between treatment modalities. In contrast, the decrease in perfusion was comparable for both irradiation modalities. We conclude that proton therapy may reduce brain-volume loss when compared to photon therapy. Arterial spin labeling Brain atrophy Cerebral blood flow Proton beam therapy Radiochemotherapy Beuthien-Baumann, Bettina 1962- verfasserin (DE-588)12003560X (DE-627)080400418 (DE-576)292006713 aut Enthalten in Radiotherapy and oncology Amsterdam [u.a.] : Elsevier Science, 1983 128(2018), 1, Seite 121-127 Online-Ressource (DE-627)306710110 (DE-600)1500707-8 (DE-576)082435731 1879-0887 nnns volume:128 year:2018 number:1 pages:121-127 extent:7 https://doi.org/10.1016/j.radonc.2017.11.033 Verlag Resolving-System lizenzpflichtig Volltext http://www.sciencedirect.com/science/article/pii/S0167814018300185 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 128 2018 1 121-127 7 2013 01 DE-16-250 3627856279 00 --%%-- --%%-- --%%-- --%%-- l01 21-04-20 2013 01 DE-16-250 00 s hd2018 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_16 2013 01 DE-16-250 03 s s_7 2013 01 DE-16-250 04 p (DE-627)169532921X Beuthien-Baumann, Bettina 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_10
spelling	10.1016/j.radonc.2017.11.033 doi (DE-627)1695329260 (DE-599)KXP1695329260 (OCoLC)1341315956 DE-627 ger DE-627 rda eng Petr, Jan verfasserin (DE-588)1208728598 (DE-627)1695328760 aut Photon vs. proton radiochemotherapy effects on brain tissue volume and perfusion Jan Petr, Ivan Platzek, Frank Hofheinz, Henri J. M. M. Mutsaerts, Iris Asllani, Matthias J. P. van Osch, Annekatrin Seidlitz, Pawel Krukowski, Andreas Gommlich, Bettina Beuthien-Baumann, Christina Jentsch, Jens Maus, Esther G. C. Troost, Michael Baumann, Mechthild Krause, Jörg van den Hoff Photon versus proton radiochemotherapy 19 January 2018 7 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 21.04.2020 Background and purpose - To compare the structural and hemodynamic changes of healthy brain tissue in the cerebral hemisphere contralateral to the tumor following photon and proton radiochemotherapy. - Materials and methods - Sixty-seven patients (54.9±14.0years) diagnosed with glioblastoma undergoing adjuvant photon (n=47) or proton (n=19) radiochemotherapy with temozolomide after tumor resection underwent T1-weighted and arterial spin labeling MRI. Changes in volume and perfusion before and 3 to 6months after were compared between therapies. - Results - A decrease in gray matter (GM) (−2.2%, P<0.001) and white matter (WM) (−1.2%, P<0.001) volume was observed in photon-therapy patients compared to the pre-radiotherapy baseline. In contrast, for the proton-therapy group, no significant differences in GM (0.3%, P=0.64) or WM (−0.4%, P=0.58) volume were observed. GM volume decreased with 0.9% per 10Gy dose increase (P<0.001) and differed between the radiation modalities (P<0.001). Perfusion decreased in photon-therapy patients (−10.1%, P=0.002), whereas the decrease in proton-therapy patients, while comparable in magnitude, did not reach statistical significance (−9.1%, P=0.12). There was no correlation between perfusion decrease and either dose (P=0.64) or radiation modality (P=0.94). - Conclusions - Our results show that the tissue volume decrease depends on radiation dose delivered to the healthy hemisphere and differs between treatment modalities. In contrast, the decrease in perfusion was comparable for both irradiation modalities. We conclude that proton therapy may reduce brain-volume loss when compared to photon therapy. Arterial spin labeling Brain atrophy Cerebral blood flow Proton beam therapy Radiochemotherapy Beuthien-Baumann, Bettina 1962- verfasserin (DE-588)12003560X (DE-627)080400418 (DE-576)292006713 aut Enthalten in Radiotherapy and oncology Amsterdam [u.a.] : Elsevier Science, 1983 128(2018), 1, Seite 121-127 Online-Ressource (DE-627)306710110 (DE-600)1500707-8 (DE-576)082435731 1879-0887 nnns volume:128 year:2018 number:1 pages:121-127 extent:7 https://doi.org/10.1016/j.radonc.2017.11.033 Verlag Resolving-System lizenzpflichtig Volltext http://www.sciencedirect.com/science/article/pii/S0167814018300185 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 128 2018 1 121-127 7 2013 01 DE-16-250 3627856279 00 --%%-- --%%-- --%%-- --%%-- l01 21-04-20 2013 01 DE-16-250 00 s hd2018 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_16 2013 01 DE-16-250 03 s s_7 2013 01 DE-16-250 04 p (DE-627)169532921X Beuthien-Baumann, Bettina 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_10
allfields_unstemmed	10.1016/j.radonc.2017.11.033 doi (DE-627)1695329260 (DE-599)KXP1695329260 (OCoLC)1341315956 DE-627 ger DE-627 rda eng Petr, Jan verfasserin (DE-588)1208728598 (DE-627)1695328760 aut Photon vs. proton radiochemotherapy effects on brain tissue volume and perfusion Jan Petr, Ivan Platzek, Frank Hofheinz, Henri J. M. M. Mutsaerts, Iris Asllani, Matthias J. P. van Osch, Annekatrin Seidlitz, Pawel Krukowski, Andreas Gommlich, Bettina Beuthien-Baumann, Christina Jentsch, Jens Maus, Esther G. C. Troost, Michael Baumann, Mechthild Krause, Jörg van den Hoff Photon versus proton radiochemotherapy 19 January 2018 7 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 21.04.2020 Background and purpose - To compare the structural and hemodynamic changes of healthy brain tissue in the cerebral hemisphere contralateral to the tumor following photon and proton radiochemotherapy. - Materials and methods - Sixty-seven patients (54.9±14.0years) diagnosed with glioblastoma undergoing adjuvant photon (n=47) or proton (n=19) radiochemotherapy with temozolomide after tumor resection underwent T1-weighted and arterial spin labeling MRI. Changes in volume and perfusion before and 3 to 6months after were compared between therapies. - Results - A decrease in gray matter (GM) (−2.2%, P<0.001) and white matter (WM) (−1.2%, P<0.001) volume was observed in photon-therapy patients compared to the pre-radiotherapy baseline. In contrast, for the proton-therapy group, no significant differences in GM (0.3%, P=0.64) or WM (−0.4%, P=0.58) volume were observed. GM volume decreased with 0.9% per 10Gy dose increase (P<0.001) and differed between the radiation modalities (P<0.001). Perfusion decreased in photon-therapy patients (−10.1%, P=0.002), whereas the decrease in proton-therapy patients, while comparable in magnitude, did not reach statistical significance (−9.1%, P=0.12). There was no correlation between perfusion decrease and either dose (P=0.64) or radiation modality (P=0.94). - Conclusions - Our results show that the tissue volume decrease depends on radiation dose delivered to the healthy hemisphere and differs between treatment modalities. In contrast, the decrease in perfusion was comparable for both irradiation modalities. We conclude that proton therapy may reduce brain-volume loss when compared to photon therapy. Arterial spin labeling Brain atrophy Cerebral blood flow Proton beam therapy Radiochemotherapy Beuthien-Baumann, Bettina 1962- verfasserin (DE-588)12003560X (DE-627)080400418 (DE-576)292006713 aut Enthalten in Radiotherapy and oncology Amsterdam [u.a.] : Elsevier Science, 1983 128(2018), 1, Seite 121-127 Online-Ressource (DE-627)306710110 (DE-600)1500707-8 (DE-576)082435731 1879-0887 nnns volume:128 year:2018 number:1 pages:121-127 extent:7 https://doi.org/10.1016/j.radonc.2017.11.033 Verlag Resolving-System lizenzpflichtig Volltext http://www.sciencedirect.com/science/article/pii/S0167814018300185 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 128 2018 1 121-127 7 2013 01 DE-16-250 3627856279 00 --%%-- --%%-- --%%-- --%%-- l01 21-04-20 2013 01 DE-16-250 00 s hd2018 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_16 2013 01 DE-16-250 03 s s_7 2013 01 DE-16-250 04 p (DE-627)169532921X Beuthien-Baumann, Bettina 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_10
allfieldsGer	10.1016/j.radonc.2017.11.033 doi (DE-627)1695329260 (DE-599)KXP1695329260 (OCoLC)1341315956 DE-627 ger DE-627 rda eng Petr, Jan verfasserin (DE-588)1208728598 (DE-627)1695328760 aut Photon vs. proton radiochemotherapy effects on brain tissue volume and perfusion Jan Petr, Ivan Platzek, Frank Hofheinz, Henri J. M. M. Mutsaerts, Iris Asllani, Matthias J. P. van Osch, Annekatrin Seidlitz, Pawel Krukowski, Andreas Gommlich, Bettina Beuthien-Baumann, Christina Jentsch, Jens Maus, Esther G. C. Troost, Michael Baumann, Mechthild Krause, Jörg van den Hoff Photon versus proton radiochemotherapy 19 January 2018 7 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 21.04.2020 Background and purpose - To compare the structural and hemodynamic changes of healthy brain tissue in the cerebral hemisphere contralateral to the tumor following photon and proton radiochemotherapy. - Materials and methods - Sixty-seven patients (54.9±14.0years) diagnosed with glioblastoma undergoing adjuvant photon (n=47) or proton (n=19) radiochemotherapy with temozolomide after tumor resection underwent T1-weighted and arterial spin labeling MRI. Changes in volume and perfusion before and 3 to 6months after were compared between therapies. - Results - A decrease in gray matter (GM) (−2.2%, P<0.001) and white matter (WM) (−1.2%, P<0.001) volume was observed in photon-therapy patients compared to the pre-radiotherapy baseline. In contrast, for the proton-therapy group, no significant differences in GM (0.3%, P=0.64) or WM (−0.4%, P=0.58) volume were observed. GM volume decreased with 0.9% per 10Gy dose increase (P<0.001) and differed between the radiation modalities (P<0.001). Perfusion decreased in photon-therapy patients (−10.1%, P=0.002), whereas the decrease in proton-therapy patients, while comparable in magnitude, did not reach statistical significance (−9.1%, P=0.12). There was no correlation between perfusion decrease and either dose (P=0.64) or radiation modality (P=0.94). - Conclusions - Our results show that the tissue volume decrease depends on radiation dose delivered to the healthy hemisphere and differs between treatment modalities. In contrast, the decrease in perfusion was comparable for both irradiation modalities. We conclude that proton therapy may reduce brain-volume loss when compared to photon therapy. Arterial spin labeling Brain atrophy Cerebral blood flow Proton beam therapy Radiochemotherapy Beuthien-Baumann, Bettina 1962- verfasserin (DE-588)12003560X (DE-627)080400418 (DE-576)292006713 aut Enthalten in Radiotherapy and oncology Amsterdam [u.a.] : Elsevier Science, 1983 128(2018), 1, Seite 121-127 Online-Ressource (DE-627)306710110 (DE-600)1500707-8 (DE-576)082435731 1879-0887 nnns volume:128 year:2018 number:1 pages:121-127 extent:7 https://doi.org/10.1016/j.radonc.2017.11.033 Verlag Resolving-System lizenzpflichtig Volltext http://www.sciencedirect.com/science/article/pii/S0167814018300185 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 128 2018 1 121-127 7 2013 01 DE-16-250 3627856279 00 --%%-- --%%-- --%%-- --%%-- l01 21-04-20 2013 01 DE-16-250 00 s hd2018 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_16 2013 01 DE-16-250 03 s s_7 2013 01 DE-16-250 04 p (DE-627)169532921X Beuthien-Baumann, Bettina 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_10
allfieldsSound	10.1016/j.radonc.2017.11.033 doi (DE-627)1695329260 (DE-599)KXP1695329260 (OCoLC)1341315956 DE-627 ger DE-627 rda eng Petr, Jan verfasserin (DE-588)1208728598 (DE-627)1695328760 aut Photon vs. proton radiochemotherapy effects on brain tissue volume and perfusion Jan Petr, Ivan Platzek, Frank Hofheinz, Henri J. M. M. Mutsaerts, Iris Asllani, Matthias J. P. van Osch, Annekatrin Seidlitz, Pawel Krukowski, Andreas Gommlich, Bettina Beuthien-Baumann, Christina Jentsch, Jens Maus, Esther G. C. Troost, Michael Baumann, Mechthild Krause, Jörg van den Hoff Photon versus proton radiochemotherapy 19 January 2018 7 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 21.04.2020 Background and purpose - To compare the structural and hemodynamic changes of healthy brain tissue in the cerebral hemisphere contralateral to the tumor following photon and proton radiochemotherapy. - Materials and methods - Sixty-seven patients (54.9±14.0years) diagnosed with glioblastoma undergoing adjuvant photon (n=47) or proton (n=19) radiochemotherapy with temozolomide after tumor resection underwent T1-weighted and arterial spin labeling MRI. Changes in volume and perfusion before and 3 to 6months after were compared between therapies. - Results - A decrease in gray matter (GM) (−2.2%, P<0.001) and white matter (WM) (−1.2%, P<0.001) volume was observed in photon-therapy patients compared to the pre-radiotherapy baseline. In contrast, for the proton-therapy group, no significant differences in GM (0.3%, P=0.64) or WM (−0.4%, P=0.58) volume were observed. GM volume decreased with 0.9% per 10Gy dose increase (P<0.001) and differed between the radiation modalities (P<0.001). Perfusion decreased in photon-therapy patients (−10.1%, P=0.002), whereas the decrease in proton-therapy patients, while comparable in magnitude, did not reach statistical significance (−9.1%, P=0.12). There was no correlation between perfusion decrease and either dose (P=0.64) or radiation modality (P=0.94). - Conclusions - Our results show that the tissue volume decrease depends on radiation dose delivered to the healthy hemisphere and differs between treatment modalities. In contrast, the decrease in perfusion was comparable for both irradiation modalities. We conclude that proton therapy may reduce brain-volume loss when compared to photon therapy. Arterial spin labeling Brain atrophy Cerebral blood flow Proton beam therapy Radiochemotherapy Beuthien-Baumann, Bettina 1962- verfasserin (DE-588)12003560X (DE-627)080400418 (DE-576)292006713 aut Enthalten in Radiotherapy and oncology Amsterdam [u.a.] : Elsevier Science, 1983 128(2018), 1, Seite 121-127 Online-Ressource (DE-627)306710110 (DE-600)1500707-8 (DE-576)082435731 1879-0887 nnns volume:128 year:2018 number:1 pages:121-127 extent:7 https://doi.org/10.1016/j.radonc.2017.11.033 Verlag Resolving-System lizenzpflichtig Volltext http://www.sciencedirect.com/science/article/pii/S0167814018300185 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 128 2018 1 121-127 7 2013 01 DE-16-250 3627856279 00 --%%-- --%%-- --%%-- --%%-- l01 21-04-20 2013 01 DE-16-250 00 s hd2018 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_16 2013 01 DE-16-250 03 s s_7 2013 01 DE-16-250 04 p (DE-627)169532921X Beuthien-Baumann, Bettina 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_10
language	English
source	Enthalten in Radiotherapy and oncology 128(2018), 1, Seite 121-127 volume:128 year:2018 number:1 pages:121-127 extent:7
sourceStr	Enthalten in Radiotherapy and oncology 128(2018), 1, Seite 121-127 volume:128 year:2018 number:1 pages:121-127 extent:7
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institution	findex.gbv.de
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topic_facet	Arterial spin labeling Brain atrophy Cerebral blood flow Proton beam therapy Radiochemotherapy
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container_title	Radiotherapy and oncology
authorswithroles_txt_mv	Petr, Jan @@aut@@ Beuthien-Baumann, Bettina @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
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M. M. Mutsaerts, Iris Asllani, Matthias J. P. van Osch, Annekatrin Seidlitz, Pawel Krukowski, Andreas Gommlich, Bettina Beuthien-Baumann, Christina Jentsch, Jens Maus, Esther G. C. 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title	Photon vs. proton radiochemotherapy effects on brain tissue volume and perfusion
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title_full	Photon vs. proton radiochemotherapy effects on brain tissue volume and perfusion Jan Petr, Ivan Platzek, Frank Hofheinz, Henri J. M. M. Mutsaerts, Iris Asllani, Matthias J. P. van Osch, Annekatrin Seidlitz, Pawel Krukowski, Andreas Gommlich, Bettina Beuthien-Baumann, Christina Jentsch, Jens Maus, Esther G. C. Troost, Michael Baumann, Mechthild Krause, Jörg van den Hoff
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title_sort	photon vs. proton radiochemotherapyeffects on brain tissue volume and perfusion
title_auth	Photon vs. proton radiochemotherapy effects on brain tissue volume and perfusion
abstract	Background and purpose - To compare the structural and hemodynamic changes of healthy brain tissue in the cerebral hemisphere contralateral to the tumor following photon and proton radiochemotherapy. - Materials and methods - Sixty-seven patients (54.9±14.0years) diagnosed with glioblastoma undergoing adjuvant photon (n=47) or proton (n=19) radiochemotherapy with temozolomide after tumor resection underwent T1-weighted and arterial spin labeling MRI. Changes in volume and perfusion before and 3 to 6months after were compared between therapies. - Results - A decrease in gray matter (GM) (−2.2%, P<0.001) and white matter (WM) (−1.2%, P<0.001) volume was observed in photon-therapy patients compared to the pre-radiotherapy baseline. In contrast, for the proton-therapy group, no significant differences in GM (0.3%, P=0.64) or WM (−0.4%, P=0.58) volume were observed. GM volume decreased with 0.9% per 10Gy dose increase (P<0.001) and differed between the radiation modalities (P<0.001). Perfusion decreased in photon-therapy patients (−10.1%, P=0.002), whereas the decrease in proton-therapy patients, while comparable in magnitude, did not reach statistical significance (−9.1%, P=0.12). There was no correlation between perfusion decrease and either dose (P=0.64) or radiation modality (P=0.94). - Conclusions - Our results show that the tissue volume decrease depends on radiation dose delivered to the healthy hemisphere and differs between treatment modalities. In contrast, the decrease in perfusion was comparable for both irradiation modalities. We conclude that proton therapy may reduce brain-volume loss when compared to photon therapy. Gesehen am 21.04.2020
abstractGer	Background and purpose - To compare the structural and hemodynamic changes of healthy brain tissue in the cerebral hemisphere contralateral to the tumor following photon and proton radiochemotherapy. - Materials and methods - Sixty-seven patients (54.9±14.0years) diagnosed with glioblastoma undergoing adjuvant photon (n=47) or proton (n=19) radiochemotherapy with temozolomide after tumor resection underwent T1-weighted and arterial spin labeling MRI. Changes in volume and perfusion before and 3 to 6months after were compared between therapies. - Results - A decrease in gray matter (GM) (−2.2%, P<0.001) and white matter (WM) (−1.2%, P<0.001) volume was observed in photon-therapy patients compared to the pre-radiotherapy baseline. In contrast, for the proton-therapy group, no significant differences in GM (0.3%, P=0.64) or WM (−0.4%, P=0.58) volume were observed. GM volume decreased with 0.9% per 10Gy dose increase (P<0.001) and differed between the radiation modalities (P<0.001). Perfusion decreased in photon-therapy patients (−10.1%, P=0.002), whereas the decrease in proton-therapy patients, while comparable in magnitude, did not reach statistical significance (−9.1%, P=0.12). There was no correlation between perfusion decrease and either dose (P=0.64) or radiation modality (P=0.94). - Conclusions - Our results show that the tissue volume decrease depends on radiation dose delivered to the healthy hemisphere and differs between treatment modalities. In contrast, the decrease in perfusion was comparable for both irradiation modalities. We conclude that proton therapy may reduce brain-volume loss when compared to photon therapy. Gesehen am 21.04.2020
abstract_unstemmed	Background and purpose - To compare the structural and hemodynamic changes of healthy brain tissue in the cerebral hemisphere contralateral to the tumor following photon and proton radiochemotherapy. - Materials and methods - Sixty-seven patients (54.9±14.0years) diagnosed with glioblastoma undergoing adjuvant photon (n=47) or proton (n=19) radiochemotherapy with temozolomide after tumor resection underwent T1-weighted and arterial spin labeling MRI. Changes in volume and perfusion before and 3 to 6months after were compared between therapies. - Results - A decrease in gray matter (GM) (−2.2%, P<0.001) and white matter (WM) (−1.2%, P<0.001) volume was observed in photon-therapy patients compared to the pre-radiotherapy baseline. In contrast, for the proton-therapy group, no significant differences in GM (0.3%, P=0.64) or WM (−0.4%, P=0.58) volume were observed. GM volume decreased with 0.9% per 10Gy dose increase (P<0.001) and differed between the radiation modalities (P<0.001). Perfusion decreased in photon-therapy patients (−10.1%, P=0.002), whereas the decrease in proton-therapy patients, while comparable in magnitude, did not reach statistical significance (−9.1%, P=0.12). There was no correlation between perfusion decrease and either dose (P=0.64) or radiation modality (P=0.94). - Conclusions - Our results show that the tissue volume decrease depends on radiation dose delivered to the healthy hemisphere and differs between treatment modalities. In contrast, the decrease in perfusion was comparable for both irradiation modalities. We conclude that proton therapy may reduce brain-volume loss when compared to photon therapy. Gesehen am 21.04.2020
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title_short	Photon vs. proton radiochemotherapy
url	https://doi.org/10.1016/j.radonc.2017.11.033 http://www.sciencedirect.com/science/article/pii/S0167814018300185
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author2	Beuthien-Baumann, Bettina 1962-
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GND_str_mv	Petr, Jan Beuthien, Bettina Baumann, Bettina Beuthien- Beuthien-Baumann, Bettina
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title_alt	Photon versus proton radiochemotherapy
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doi_str	10.1016/j.radonc.2017.11.033
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up_date	2024-07-05T01:21:48.060Z
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