Structure and switch cycle of SRβ as ancestral eukaryotic GTPase associated with secretory membranes
G proteins of the Ras-family of small GTPases trace the evolution of eukaryotes. The earliest branching involves the closely related Arf, Sar1, and SRβ GTPases associated with secretory membranes. SRβ is an integral membrane component of the signal recognition particle (SRP) receptor that targets ri...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Jadhav, Bhalchandra [verfasserIn] Wild, Klemens [verfasserIn] Sinning, Irmgard - 1960- [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
August 20, 2015 |
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| Anmerkung: |
Im Titel wird beta als griechischer Buchstabe dargestellt Gesehen am 05.06.2020 |
|---|---|
| Umfang: |
11 |
| Übergeordnetes Werk: |
Enthalten in: Structure - London [u.a.] : Elsevier Science, 1993, 23(2015), 10, Seite 1838-1847 |
|---|---|
| Übergeordnetes Werk: |
volume:23 ; year:2015 ; number:10 ; pages:1838-1847 ; extent:11 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.str.2015.07.010 |
|---|
| Katalog-ID: |
1700094017 |
|---|
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| 245 | 1 | 0 | |a Structure and switch cycle of SRβ as ancestral eukaryotic GTPase associated with secretory membranes |c Bhalchandra Jadhav, Klemens Wild, Martin R. Pool, and Irmgard Sinning |
| 246 | 3 | 3 | |a Structure and switch cycle of SRbeta as ancestral eukaryotic GTPase associated with secretory membranes |
| 264 | 1 | |c August 20, 2015 | |
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| 520 | |a G proteins of the Ras-family of small GTPases trace the evolution of eukaryotes. The earliest branching involves the closely related Arf, Sar1, and SRβ GTPases associated with secretory membranes. SRβ is an integral membrane component of the signal recognition particle (SRP) receptor that targets ribosome-nascent chain complexes to the ER. How SRβ integrates into the regulation of SRP-dependent membrane protein biogenesis is not known. Here we show that SRβ-GTP interacts with ribosomes only in presence of SRα and present crystal structures of SRβ in complex with the SRX domain of SRα in the GTP-bound state at 3.2 Å, and of GDP- and GDP·Mg2+-bound SRβ at 1.9 Å and 2.4 Å, respectively. We define the GTPase switch cycle of SRβ and identify specific differences to the Arf and Sar1 families with implications for GTPase regulation. Our data allow a better integration of SRβ into the scheme of protein targeting. | ||
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| 912 | |a GBV_ILN_2048 | ||
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| 912 | |a GBV_ILN_2055 | ||
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| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
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| 912 | |a GBV_ILN_2152 | ||
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| 912 | |a GBV_ILN_2190 | ||
| 912 | |a GBV_ILN_2336 | ||
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| 912 | |a GBV_ILN_2507 | ||
| 912 | |a GBV_ILN_2522 | ||
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| 912 | |a GBV_ILN_4035 | ||
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| 912 | |a GBV_ILN_4125 | ||
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| 912 | |a GBV_ILN_4242 | ||
| 912 | |a GBV_ILN_4249 | ||
| 912 | |a GBV_ILN_4251 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4306 | ||
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| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
| 912 | |a GBV_ILN_4323 | ||
| 912 | |a GBV_ILN_4324 | ||
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August 20, 2015 |
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2015 |
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10.1016/j.str.2015.07.010 doi (DE-627)1700094017 (DE-599)KXP1700094017 (OCoLC)1341339130 DE-627 ger DE-627 rda eng Jadhav, Bhalchandra verfasserin (DE-588)1211582809 (DE-627)1700097784 aut Structure and switch cycle of SRβ as ancestral eukaryotic GTPase associated with secretory membranes Bhalchandra Jadhav, Klemens Wild, Martin R. Pool, and Irmgard Sinning Structure and switch cycle of SRbeta as ancestral eukaryotic GTPase associated with secretory membranes August 20, 2015 11 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Im Titel wird beta als griechischer Buchstabe dargestellt Gesehen am 05.06.2020 G proteins of the Ras-family of small GTPases trace the evolution of eukaryotes. The earliest branching involves the closely related Arf, Sar1, and SRβ GTPases associated with secretory membranes. SRβ is an integral membrane component of the signal recognition particle (SRP) receptor that targets ribosome-nascent chain complexes to the ER. How SRβ integrates into the regulation of SRP-dependent membrane protein biogenesis is not known. Here we show that SRβ-GTP interacts with ribosomes only in presence of SRα and present crystal structures of SRβ in complex with the SRX domain of SRα in the GTP-bound state at 3.2 Å, and of GDP- and GDP·Mg2+-bound SRβ at 1.9 Å and 2.4 Å, respectively. We define the GTPase switch cycle of SRβ and identify specific differences to the Arf and Sar1 families with implications for GTPase regulation. Our data allow a better integration of SRβ into the scheme of protein targeting. Wild, Klemens verfasserin (DE-588)1049291190 (DE-627)781602394 (DE-576)177410892 aut Sinning, Irmgard 1960- verfasserin (DE-588)1027598617 (DE-627)72945133X (DE-576)166290580 aut Enthalten in Structure London [u.a.] : Elsevier Science, 1993 23(2015), 10, Seite 1838-1847 Online-Ressource (DE-627)324826052 (DE-600)2031189-8 (DE-576)094108269 1878-4186 nnns volume:23 year:2015 number:10 pages:1838-1847 extent:11 https://doi.org/10.1016/j.str.2015.07.010 Verlag Resolving-System lizenzpflichtig Volltext http://www.sciencedirect.com/science/article/pii/S0969212615002920 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2015 10 1838-1847 11 2013 01 DE-16-250 3683769149 00 --%%-- --%%-- --%%-- --%%-- l01 05-06-20 2013 01 DE-16-250 00 s hd2015 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_4 2013 01 DE-16-250 03 s s_11 2013 01 DE-16-250 04 p (DE-627)1700098578 Jadhav, Bhalchandra 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1473261473 Wild, Klemens 2013 01 DE-16-250 05 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1443444928 Sinning, Irmgard 2013 01 DE-16-250 06 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 |
| spelling |
10.1016/j.str.2015.07.010 doi (DE-627)1700094017 (DE-599)KXP1700094017 (OCoLC)1341339130 DE-627 ger DE-627 rda eng Jadhav, Bhalchandra verfasserin (DE-588)1211582809 (DE-627)1700097784 aut Structure and switch cycle of SRβ as ancestral eukaryotic GTPase associated with secretory membranes Bhalchandra Jadhav, Klemens Wild, Martin R. Pool, and Irmgard Sinning Structure and switch cycle of SRbeta as ancestral eukaryotic GTPase associated with secretory membranes August 20, 2015 11 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Im Titel wird beta als griechischer Buchstabe dargestellt Gesehen am 05.06.2020 G proteins of the Ras-family of small GTPases trace the evolution of eukaryotes. The earliest branching involves the closely related Arf, Sar1, and SRβ GTPases associated with secretory membranes. SRβ is an integral membrane component of the signal recognition particle (SRP) receptor that targets ribosome-nascent chain complexes to the ER. How SRβ integrates into the regulation of SRP-dependent membrane protein biogenesis is not known. Here we show that SRβ-GTP interacts with ribosomes only in presence of SRα and present crystal structures of SRβ in complex with the SRX domain of SRα in the GTP-bound state at 3.2 Å, and of GDP- and GDP·Mg2+-bound SRβ at 1.9 Å and 2.4 Å, respectively. We define the GTPase switch cycle of SRβ and identify specific differences to the Arf and Sar1 families with implications for GTPase regulation. Our data allow a better integration of SRβ into the scheme of protein targeting. Wild, Klemens verfasserin (DE-588)1049291190 (DE-627)781602394 (DE-576)177410892 aut Sinning, Irmgard 1960- verfasserin (DE-588)1027598617 (DE-627)72945133X (DE-576)166290580 aut Enthalten in Structure London [u.a.] : Elsevier Science, 1993 23(2015), 10, Seite 1838-1847 Online-Ressource (DE-627)324826052 (DE-600)2031189-8 (DE-576)094108269 1878-4186 nnns volume:23 year:2015 number:10 pages:1838-1847 extent:11 https://doi.org/10.1016/j.str.2015.07.010 Verlag Resolving-System lizenzpflichtig Volltext http://www.sciencedirect.com/science/article/pii/S0969212615002920 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2015 10 1838-1847 11 2013 01 DE-16-250 3683769149 00 --%%-- --%%-- --%%-- --%%-- l01 05-06-20 2013 01 DE-16-250 00 s hd2015 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_4 2013 01 DE-16-250 03 s s_11 2013 01 DE-16-250 04 p (DE-627)1700098578 Jadhav, Bhalchandra 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1473261473 Wild, Klemens 2013 01 DE-16-250 05 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1443444928 Sinning, Irmgard 2013 01 DE-16-250 06 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 |
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10.1016/j.str.2015.07.010 doi (DE-627)1700094017 (DE-599)KXP1700094017 (OCoLC)1341339130 DE-627 ger DE-627 rda eng Jadhav, Bhalchandra verfasserin (DE-588)1211582809 (DE-627)1700097784 aut Structure and switch cycle of SRβ as ancestral eukaryotic GTPase associated with secretory membranes Bhalchandra Jadhav, Klemens Wild, Martin R. Pool, and Irmgard Sinning Structure and switch cycle of SRbeta as ancestral eukaryotic GTPase associated with secretory membranes August 20, 2015 11 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Im Titel wird beta als griechischer Buchstabe dargestellt Gesehen am 05.06.2020 G proteins of the Ras-family of small GTPases trace the evolution of eukaryotes. The earliest branching involves the closely related Arf, Sar1, and SRβ GTPases associated with secretory membranes. SRβ is an integral membrane component of the signal recognition particle (SRP) receptor that targets ribosome-nascent chain complexes to the ER. How SRβ integrates into the regulation of SRP-dependent membrane protein biogenesis is not known. Here we show that SRβ-GTP interacts with ribosomes only in presence of SRα and present crystal structures of SRβ in complex with the SRX domain of SRα in the GTP-bound state at 3.2 Å, and of GDP- and GDP·Mg2+-bound SRβ at 1.9 Å and 2.4 Å, respectively. We define the GTPase switch cycle of SRβ and identify specific differences to the Arf and Sar1 families with implications for GTPase regulation. Our data allow a better integration of SRβ into the scheme of protein targeting. Wild, Klemens verfasserin (DE-588)1049291190 (DE-627)781602394 (DE-576)177410892 aut Sinning, Irmgard 1960- verfasserin (DE-588)1027598617 (DE-627)72945133X (DE-576)166290580 aut Enthalten in Structure London [u.a.] : Elsevier Science, 1993 23(2015), 10, Seite 1838-1847 Online-Ressource (DE-627)324826052 (DE-600)2031189-8 (DE-576)094108269 1878-4186 nnns volume:23 year:2015 number:10 pages:1838-1847 extent:11 https://doi.org/10.1016/j.str.2015.07.010 Verlag Resolving-System lizenzpflichtig Volltext http://www.sciencedirect.com/science/article/pii/S0969212615002920 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2015 10 1838-1847 11 2013 01 DE-16-250 3683769149 00 --%%-- --%%-- --%%-- --%%-- l01 05-06-20 2013 01 DE-16-250 00 s hd2015 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_4 2013 01 DE-16-250 03 s s_11 2013 01 DE-16-250 04 p (DE-627)1700098578 Jadhav, Bhalchandra 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1473261473 Wild, Klemens 2013 01 DE-16-250 05 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1443444928 Sinning, Irmgard 2013 01 DE-16-250 06 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 |
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10.1016/j.str.2015.07.010 doi (DE-627)1700094017 (DE-599)KXP1700094017 (OCoLC)1341339130 DE-627 ger DE-627 rda eng Jadhav, Bhalchandra verfasserin (DE-588)1211582809 (DE-627)1700097784 aut Structure and switch cycle of SRβ as ancestral eukaryotic GTPase associated with secretory membranes Bhalchandra Jadhav, Klemens Wild, Martin R. Pool, and Irmgard Sinning Structure and switch cycle of SRbeta as ancestral eukaryotic GTPase associated with secretory membranes August 20, 2015 11 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Im Titel wird beta als griechischer Buchstabe dargestellt Gesehen am 05.06.2020 G proteins of the Ras-family of small GTPases trace the evolution of eukaryotes. The earliest branching involves the closely related Arf, Sar1, and SRβ GTPases associated with secretory membranes. SRβ is an integral membrane component of the signal recognition particle (SRP) receptor that targets ribosome-nascent chain complexes to the ER. How SRβ integrates into the regulation of SRP-dependent membrane protein biogenesis is not known. Here we show that SRβ-GTP interacts with ribosomes only in presence of SRα and present crystal structures of SRβ in complex with the SRX domain of SRα in the GTP-bound state at 3.2 Å, and of GDP- and GDP·Mg2+-bound SRβ at 1.9 Å and 2.4 Å, respectively. We define the GTPase switch cycle of SRβ and identify specific differences to the Arf and Sar1 families with implications for GTPase regulation. Our data allow a better integration of SRβ into the scheme of protein targeting. Wild, Klemens verfasserin (DE-588)1049291190 (DE-627)781602394 (DE-576)177410892 aut Sinning, Irmgard 1960- verfasserin (DE-588)1027598617 (DE-627)72945133X (DE-576)166290580 aut Enthalten in Structure London [u.a.] : Elsevier Science, 1993 23(2015), 10, Seite 1838-1847 Online-Ressource (DE-627)324826052 (DE-600)2031189-8 (DE-576)094108269 1878-4186 nnns volume:23 year:2015 number:10 pages:1838-1847 extent:11 https://doi.org/10.1016/j.str.2015.07.010 Verlag Resolving-System lizenzpflichtig Volltext http://www.sciencedirect.com/science/article/pii/S0969212615002920 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2015 10 1838-1847 11 2013 01 DE-16-250 3683769149 00 --%%-- --%%-- --%%-- --%%-- l01 05-06-20 2013 01 DE-16-250 00 s hd2015 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_4 2013 01 DE-16-250 03 s s_11 2013 01 DE-16-250 04 p (DE-627)1700098578 Jadhav, Bhalchandra 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1473261473 Wild, Klemens 2013 01 DE-16-250 05 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1443444928 Sinning, Irmgard 2013 01 DE-16-250 06 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 |
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10.1016/j.str.2015.07.010 doi (DE-627)1700094017 (DE-599)KXP1700094017 (OCoLC)1341339130 DE-627 ger DE-627 rda eng Jadhav, Bhalchandra verfasserin (DE-588)1211582809 (DE-627)1700097784 aut Structure and switch cycle of SRβ as ancestral eukaryotic GTPase associated with secretory membranes Bhalchandra Jadhav, Klemens Wild, Martin R. Pool, and Irmgard Sinning Structure and switch cycle of SRbeta as ancestral eukaryotic GTPase associated with secretory membranes August 20, 2015 11 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Im Titel wird beta als griechischer Buchstabe dargestellt Gesehen am 05.06.2020 G proteins of the Ras-family of small GTPases trace the evolution of eukaryotes. The earliest branching involves the closely related Arf, Sar1, and SRβ GTPases associated with secretory membranes. SRβ is an integral membrane component of the signal recognition particle (SRP) receptor that targets ribosome-nascent chain complexes to the ER. How SRβ integrates into the regulation of SRP-dependent membrane protein biogenesis is not known. Here we show that SRβ-GTP interacts with ribosomes only in presence of SRα and present crystal structures of SRβ in complex with the SRX domain of SRα in the GTP-bound state at 3.2 Å, and of GDP- and GDP·Mg2+-bound SRβ at 1.9 Å and 2.4 Å, respectively. We define the GTPase switch cycle of SRβ and identify specific differences to the Arf and Sar1 families with implications for GTPase regulation. Our data allow a better integration of SRβ into the scheme of protein targeting. Wild, Klemens verfasserin (DE-588)1049291190 (DE-627)781602394 (DE-576)177410892 aut Sinning, Irmgard 1960- verfasserin (DE-588)1027598617 (DE-627)72945133X (DE-576)166290580 aut Enthalten in Structure London [u.a.] : Elsevier Science, 1993 23(2015), 10, Seite 1838-1847 Online-Ressource (DE-627)324826052 (DE-600)2031189-8 (DE-576)094108269 1878-4186 nnns volume:23 year:2015 number:10 pages:1838-1847 extent:11 https://doi.org/10.1016/j.str.2015.07.010 Verlag Resolving-System lizenzpflichtig Volltext http://www.sciencedirect.com/science/article/pii/S0969212615002920 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2015 10 1838-1847 11 2013 01 DE-16-250 3683769149 00 --%%-- --%%-- --%%-- --%%-- l01 05-06-20 2013 01 DE-16-250 00 s hd2015 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_4 2013 01 DE-16-250 03 s s_11 2013 01 DE-16-250 04 p (DE-627)1700098578 Jadhav, Bhalchandra 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1473261473 Wild, Klemens 2013 01 DE-16-250 05 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1443444928 Sinning, Irmgard 2013 01 DE-16-250 06 k (DE-627)1416733434 Biochemiezentrum der Universität Heidelberg (BZH) 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 |
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Structure and switch cycle of SRβ as ancestral eukaryotic GTPase associated with secretory membranes |
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G proteins of the Ras-family of small GTPases trace the evolution of eukaryotes. The earliest branching involves the closely related Arf, Sar1, and SRβ GTPases associated with secretory membranes. SRβ is an integral membrane component of the signal recognition particle (SRP) receptor that targets ribosome-nascent chain complexes to the ER. How SRβ integrates into the regulation of SRP-dependent membrane protein biogenesis is not known. Here we show that SRβ-GTP interacts with ribosomes only in presence of SRα and present crystal structures of SRβ in complex with the SRX domain of SRα in the GTP-bound state at 3.2 Å, and of GDP- and GDP·Mg2+-bound SRβ at 1.9 Å and 2.4 Å, respectively. We define the GTPase switch cycle of SRβ and identify specific differences to the Arf and Sar1 families with implications for GTPase regulation. Our data allow a better integration of SRβ into the scheme of protein targeting. Im Titel wird beta als griechischer Buchstabe dargestellt Gesehen am 05.06.2020 |
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G proteins of the Ras-family of small GTPases trace the evolution of eukaryotes. The earliest branching involves the closely related Arf, Sar1, and SRβ GTPases associated with secretory membranes. SRβ is an integral membrane component of the signal recognition particle (SRP) receptor that targets ribosome-nascent chain complexes to the ER. How SRβ integrates into the regulation of SRP-dependent membrane protein biogenesis is not known. Here we show that SRβ-GTP interacts with ribosomes only in presence of SRα and present crystal structures of SRβ in complex with the SRX domain of SRα in the GTP-bound state at 3.2 Å, and of GDP- and GDP·Mg2+-bound SRβ at 1.9 Å and 2.4 Å, respectively. We define the GTPase switch cycle of SRβ and identify specific differences to the Arf and Sar1 families with implications for GTPase regulation. Our data allow a better integration of SRβ into the scheme of protein targeting. Im Titel wird beta als griechischer Buchstabe dargestellt Gesehen am 05.06.2020 |
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G proteins of the Ras-family of small GTPases trace the evolution of eukaryotes. The earliest branching involves the closely related Arf, Sar1, and SRβ GTPases associated with secretory membranes. SRβ is an integral membrane component of the signal recognition particle (SRP) receptor that targets ribosome-nascent chain complexes to the ER. How SRβ integrates into the regulation of SRP-dependent membrane protein biogenesis is not known. Here we show that SRβ-GTP interacts with ribosomes only in presence of SRα and present crystal structures of SRβ in complex with the SRX domain of SRα in the GTP-bound state at 3.2 Å, and of GDP- and GDP·Mg2+-bound SRβ at 1.9 Å and 2.4 Å, respectively. We define the GTPase switch cycle of SRβ and identify specific differences to the Arf and Sar1 families with implications for GTPase regulation. Our data allow a better integration of SRβ into the scheme of protein targeting. Im Titel wird beta als griechischer Buchstabe dargestellt Gesehen am 05.06.2020 |
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