Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep
Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake and naturally sleeping mice while monitoring neuronal Ca2+ activity,...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bojarskaite, Laura [verfasserIn] Bjørnstad, Daniel M. [verfasserIn] Pettersen, Klas H. [verfasserIn] Cunen, Céline [verfasserIn] Hermansen, Gudmund Horn [verfasserIn] Åbjørsbråten, Knut Sindre [verfasserIn] Chambers, Anna R. [verfasserIn] Sprengel, Rolf - 1955- [verfasserIn] Vervaeke, Koen [verfasserIn] Tang, Wannan [verfasserIn] Enger, Rune [verfasserIn] Nagelhus, Erlend A. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
06 July 2020 |
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| Anmerkung: |
Im Titel ist "2+" hochgestellt Gesehen am 02.09.2020 |
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| Übergeordnetes Werk: |
Enthalten in: Nature Communications - [London] : Springer Nature, 2010, 11(2020) Artikel-Nummer 3240, 16 Seiten |
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| Übergeordnetes Werk: |
volume:11 ; year:2020 |
| Links: |
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| DOI / URN: |
10.1038/s41467-020-17062-2 |
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| Katalog-ID: |
1728629764 |
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| 520 | |a Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake and naturally sleeping mice while monitoring neuronal Ca2+ activity, brain rhythms and behavior. We show that astrocytic Ca2+ signals exhibit distinct features across the sleep-wake cycle and are reduced during sleep compared to wakefulness. Moreover, an increase in astrocytic Ca2+ signaling precedes transitions from slow wave sleep to wakefulness, with a peak upon awakening exceeding the levels during whisking and locomotion. Finally, genetic ablation of an important astrocytic Ca2+ signaling pathway impairs slow wave sleep and results in an increased number of microarousals, abnormal brain rhythms, and an increased frequency of slow wave sleep state transitions and sleep spindles. Our findings demonstrate an essential role for astrocytic Ca2+ signaling in regulating slow wave sleep. | ||
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| 700 | 1 | |a Pettersen, Klas H. |e verfasserin |4 aut | |
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10.1038/s41467-020-17062-2 doi (DE-627)1728629764 (DE-599)KXP1728629764 (OCoLC)1341358250 DE-627 ger DE-627 rda eng Bojarskaite, Laura verfasserin (DE-588)1216971757 (DE-627)1728630223 aut Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep Laura Bojarskaite, Daniel M. Bjørnstad, Klas H. Pettersen, Céline Cunen, Gudmund Horn Hermansen, Knut Sindre Åbjørsbråten, Anna R. Chambers, Rolf Sprengel, Koen Vervaeke, Wannan Tang, Rune Enger & Erlend A. Nagelhus Astrocytic Ca 2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep 06 July 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Im Titel ist "2+" hochgestellt Gesehen am 02.09.2020 Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake and naturally sleeping mice while monitoring neuronal Ca2+ activity, brain rhythms and behavior. We show that astrocytic Ca2+ signals exhibit distinct features across the sleep-wake cycle and are reduced during sleep compared to wakefulness. Moreover, an increase in astrocytic Ca2+ signaling precedes transitions from slow wave sleep to wakefulness, with a peak upon awakening exceeding the levels during whisking and locomotion. Finally, genetic ablation of an important astrocytic Ca2+ signaling pathway impairs slow wave sleep and results in an increased number of microarousals, abnormal brain rhythms, and an increased frequency of slow wave sleep state transitions and sleep spindles. Our findings demonstrate an essential role for astrocytic Ca2+ signaling in regulating slow wave sleep. Bjørnstad, Daniel M. verfasserin aut Pettersen, Klas H. verfasserin aut Cunen, Céline verfasserin aut Hermansen, Gudmund Horn verfasserin aut Åbjørsbråten, Knut Sindre verfasserin aut Chambers, Anna R. verfasserin aut Sprengel, Rolf 1955- verfasserin (DE-588)1060395665 (DE-627)799661228 (DE-576)163694230 aut Vervaeke, Koen verfasserin aut Tang, Wannan verfasserin aut Enger, Rune verfasserin aut Nagelhus, Erlend A. verfasserin aut Enthalten in Nature Communications [London] : Springer Nature, 2010 11(2020) Artikel-Nummer 3240, 16 Seiten Online-Ressource (DE-627)626457688 (DE-600)2553671-0 (DE-576)331555905 2041-1723 nnns volume:11 year:2020 https://doi.org/10.1038/s41467-020-17062-2 Verlag Resolving-System lizenzpflichtig Volltext https://www.nature.com/articles/s41467-020-17062-2 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 11(2020) Artikel-Nummer 3240, 16 Seiten 2013 01 DE-16-250 3746080908 00 --%%-- --%%-- --%%-- --%%-- l01 02-09-20 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_12 2013 01 DE-16-250 03 s s_16 2013 01 DE-16-250 04 p (DE-627)1486474055 Sprengel, Rolf 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_8 |
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10.1038/s41467-020-17062-2 doi (DE-627)1728629764 (DE-599)KXP1728629764 (OCoLC)1341358250 DE-627 ger DE-627 rda eng Bojarskaite, Laura verfasserin (DE-588)1216971757 (DE-627)1728630223 aut Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep Laura Bojarskaite, Daniel M. Bjørnstad, Klas H. Pettersen, Céline Cunen, Gudmund Horn Hermansen, Knut Sindre Åbjørsbråten, Anna R. Chambers, Rolf Sprengel, Koen Vervaeke, Wannan Tang, Rune Enger & Erlend A. Nagelhus Astrocytic Ca 2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep 06 July 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Im Titel ist "2+" hochgestellt Gesehen am 02.09.2020 Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake and naturally sleeping mice while monitoring neuronal Ca2+ activity, brain rhythms and behavior. We show that astrocytic Ca2+ signals exhibit distinct features across the sleep-wake cycle and are reduced during sleep compared to wakefulness. Moreover, an increase in astrocytic Ca2+ signaling precedes transitions from slow wave sleep to wakefulness, with a peak upon awakening exceeding the levels during whisking and locomotion. Finally, genetic ablation of an important astrocytic Ca2+ signaling pathway impairs slow wave sleep and results in an increased number of microarousals, abnormal brain rhythms, and an increased frequency of slow wave sleep state transitions and sleep spindles. Our findings demonstrate an essential role for astrocytic Ca2+ signaling in regulating slow wave sleep. Bjørnstad, Daniel M. verfasserin aut Pettersen, Klas H. verfasserin aut Cunen, Céline verfasserin aut Hermansen, Gudmund Horn verfasserin aut Åbjørsbråten, Knut Sindre verfasserin aut Chambers, Anna R. verfasserin aut Sprengel, Rolf 1955- verfasserin (DE-588)1060395665 (DE-627)799661228 (DE-576)163694230 aut Vervaeke, Koen verfasserin aut Tang, Wannan verfasserin aut Enger, Rune verfasserin aut Nagelhus, Erlend A. verfasserin aut Enthalten in Nature Communications [London] : Springer Nature, 2010 11(2020) Artikel-Nummer 3240, 16 Seiten Online-Ressource (DE-627)626457688 (DE-600)2553671-0 (DE-576)331555905 2041-1723 nnns volume:11 year:2020 https://doi.org/10.1038/s41467-020-17062-2 Verlag Resolving-System lizenzpflichtig Volltext https://www.nature.com/articles/s41467-020-17062-2 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 11(2020) Artikel-Nummer 3240, 16 Seiten 2013 01 DE-16-250 3746080908 00 --%%-- --%%-- --%%-- --%%-- l01 02-09-20 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_12 2013 01 DE-16-250 03 s s_16 2013 01 DE-16-250 04 p (DE-627)1486474055 Sprengel, Rolf 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_8 |
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10.1038/s41467-020-17062-2 doi (DE-627)1728629764 (DE-599)KXP1728629764 (OCoLC)1341358250 DE-627 ger DE-627 rda eng Bojarskaite, Laura verfasserin (DE-588)1216971757 (DE-627)1728630223 aut Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep Laura Bojarskaite, Daniel M. Bjørnstad, Klas H. Pettersen, Céline Cunen, Gudmund Horn Hermansen, Knut Sindre Åbjørsbråten, Anna R. Chambers, Rolf Sprengel, Koen Vervaeke, Wannan Tang, Rune Enger & Erlend A. Nagelhus Astrocytic Ca 2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep 06 July 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Im Titel ist "2+" hochgestellt Gesehen am 02.09.2020 Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake and naturally sleeping mice while monitoring neuronal Ca2+ activity, brain rhythms and behavior. We show that astrocytic Ca2+ signals exhibit distinct features across the sleep-wake cycle and are reduced during sleep compared to wakefulness. Moreover, an increase in astrocytic Ca2+ signaling precedes transitions from slow wave sleep to wakefulness, with a peak upon awakening exceeding the levels during whisking and locomotion. Finally, genetic ablation of an important astrocytic Ca2+ signaling pathway impairs slow wave sleep and results in an increased number of microarousals, abnormal brain rhythms, and an increased frequency of slow wave sleep state transitions and sleep spindles. Our findings demonstrate an essential role for astrocytic Ca2+ signaling in regulating slow wave sleep. Bjørnstad, Daniel M. verfasserin aut Pettersen, Klas H. verfasserin aut Cunen, Céline verfasserin aut Hermansen, Gudmund Horn verfasserin aut Åbjørsbråten, Knut Sindre verfasserin aut Chambers, Anna R. verfasserin aut Sprengel, Rolf 1955- verfasserin (DE-588)1060395665 (DE-627)799661228 (DE-576)163694230 aut Vervaeke, Koen verfasserin aut Tang, Wannan verfasserin aut Enger, Rune verfasserin aut Nagelhus, Erlend A. verfasserin aut Enthalten in Nature Communications [London] : Springer Nature, 2010 11(2020) Artikel-Nummer 3240, 16 Seiten Online-Ressource (DE-627)626457688 (DE-600)2553671-0 (DE-576)331555905 2041-1723 nnns volume:11 year:2020 https://doi.org/10.1038/s41467-020-17062-2 Verlag Resolving-System lizenzpflichtig Volltext https://www.nature.com/articles/s41467-020-17062-2 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 11(2020) Artikel-Nummer 3240, 16 Seiten 2013 01 DE-16-250 3746080908 00 --%%-- --%%-- --%%-- --%%-- l01 02-09-20 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_12 2013 01 DE-16-250 03 s s_16 2013 01 DE-16-250 04 p (DE-627)1486474055 Sprengel, Rolf 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_8 |
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10.1038/s41467-020-17062-2 doi (DE-627)1728629764 (DE-599)KXP1728629764 (OCoLC)1341358250 DE-627 ger DE-627 rda eng Bojarskaite, Laura verfasserin (DE-588)1216971757 (DE-627)1728630223 aut Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep Laura Bojarskaite, Daniel M. Bjørnstad, Klas H. Pettersen, Céline Cunen, Gudmund Horn Hermansen, Knut Sindre Åbjørsbråten, Anna R. Chambers, Rolf Sprengel, Koen Vervaeke, Wannan Tang, Rune Enger & Erlend A. Nagelhus Astrocytic Ca 2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep 06 July 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Im Titel ist "2+" hochgestellt Gesehen am 02.09.2020 Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake and naturally sleeping mice while monitoring neuronal Ca2+ activity, brain rhythms and behavior. We show that astrocytic Ca2+ signals exhibit distinct features across the sleep-wake cycle and are reduced during sleep compared to wakefulness. Moreover, an increase in astrocytic Ca2+ signaling precedes transitions from slow wave sleep to wakefulness, with a peak upon awakening exceeding the levels during whisking and locomotion. Finally, genetic ablation of an important astrocytic Ca2+ signaling pathway impairs slow wave sleep and results in an increased number of microarousals, abnormal brain rhythms, and an increased frequency of slow wave sleep state transitions and sleep spindles. Our findings demonstrate an essential role for astrocytic Ca2+ signaling in regulating slow wave sleep. Bjørnstad, Daniel M. verfasserin aut Pettersen, Klas H. verfasserin aut Cunen, Céline verfasserin aut Hermansen, Gudmund Horn verfasserin aut Åbjørsbråten, Knut Sindre verfasserin aut Chambers, Anna R. verfasserin aut Sprengel, Rolf 1955- verfasserin (DE-588)1060395665 (DE-627)799661228 (DE-576)163694230 aut Vervaeke, Koen verfasserin aut Tang, Wannan verfasserin aut Enger, Rune verfasserin aut Nagelhus, Erlend A. verfasserin aut Enthalten in Nature Communications [London] : Springer Nature, 2010 11(2020) Artikel-Nummer 3240, 16 Seiten Online-Ressource (DE-627)626457688 (DE-600)2553671-0 (DE-576)331555905 2041-1723 nnns volume:11 year:2020 https://doi.org/10.1038/s41467-020-17062-2 Verlag Resolving-System lizenzpflichtig Volltext https://www.nature.com/articles/s41467-020-17062-2 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 11(2020) Artikel-Nummer 3240, 16 Seiten 2013 01 DE-16-250 3746080908 00 --%%-- --%%-- --%%-- --%%-- l01 02-09-20 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_12 2013 01 DE-16-250 03 s s_16 2013 01 DE-16-250 04 p (DE-627)1486474055 Sprengel, Rolf 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_8 |
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10.1038/s41467-020-17062-2 doi (DE-627)1728629764 (DE-599)KXP1728629764 (OCoLC)1341358250 DE-627 ger DE-627 rda eng Bojarskaite, Laura verfasserin (DE-588)1216971757 (DE-627)1728630223 aut Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep Laura Bojarskaite, Daniel M. Bjørnstad, Klas H. Pettersen, Céline Cunen, Gudmund Horn Hermansen, Knut Sindre Åbjørsbråten, Anna R. Chambers, Rolf Sprengel, Koen Vervaeke, Wannan Tang, Rune Enger & Erlend A. Nagelhus Astrocytic Ca 2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep 06 July 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Im Titel ist "2+" hochgestellt Gesehen am 02.09.2020 Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake and naturally sleeping mice while monitoring neuronal Ca2+ activity, brain rhythms and behavior. We show that astrocytic Ca2+ signals exhibit distinct features across the sleep-wake cycle and are reduced during sleep compared to wakefulness. Moreover, an increase in astrocytic Ca2+ signaling precedes transitions from slow wave sleep to wakefulness, with a peak upon awakening exceeding the levels during whisking and locomotion. Finally, genetic ablation of an important astrocytic Ca2+ signaling pathway impairs slow wave sleep and results in an increased number of microarousals, abnormal brain rhythms, and an increased frequency of slow wave sleep state transitions and sleep spindles. Our findings demonstrate an essential role for astrocytic Ca2+ signaling in regulating slow wave sleep. Bjørnstad, Daniel M. verfasserin aut Pettersen, Klas H. verfasserin aut Cunen, Céline verfasserin aut Hermansen, Gudmund Horn verfasserin aut Åbjørsbråten, Knut Sindre verfasserin aut Chambers, Anna R. verfasserin aut Sprengel, Rolf 1955- verfasserin (DE-588)1060395665 (DE-627)799661228 (DE-576)163694230 aut Vervaeke, Koen verfasserin aut Tang, Wannan verfasserin aut Enger, Rune verfasserin aut Nagelhus, Erlend A. verfasserin aut Enthalten in Nature Communications [London] : Springer Nature, 2010 11(2020) Artikel-Nummer 3240, 16 Seiten Online-Ressource (DE-627)626457688 (DE-600)2553671-0 (DE-576)331555905 2041-1723 nnns volume:11 year:2020 https://doi.org/10.1038/s41467-020-17062-2 Verlag Resolving-System lizenzpflichtig Volltext https://www.nature.com/articles/s41467-020-17062-2 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 11(2020) Artikel-Nummer 3240, 16 Seiten 2013 01 DE-16-250 3746080908 00 --%%-- --%%-- --%%-- --%%-- l01 02-09-20 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_12 2013 01 DE-16-250 03 s s_16 2013 01 DE-16-250 04 p (DE-627)1486474055 Sprengel, Rolf 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_8 |
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Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep Laura Bojarskaite, Daniel M. Bjørnstad, Klas H. Pettersen, Céline Cunen, Gudmund Horn Hermansen, Knut Sindre Åbjørsbråten, Anna R. Chambers, Rolf Sprengel, Koen Vervaeke, Wannan Tang, Rune Enger & Erlend A. Nagelhus |
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Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep |
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Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake and naturally sleeping mice while monitoring neuronal Ca2+ activity, brain rhythms and behavior. We show that astrocytic Ca2+ signals exhibit distinct features across the sleep-wake cycle and are reduced during sleep compared to wakefulness. Moreover, an increase in astrocytic Ca2+ signaling precedes transitions from slow wave sleep to wakefulness, with a peak upon awakening exceeding the levels during whisking and locomotion. Finally, genetic ablation of an important astrocytic Ca2+ signaling pathway impairs slow wave sleep and results in an increased number of microarousals, abnormal brain rhythms, and an increased frequency of slow wave sleep state transitions and sleep spindles. Our findings demonstrate an essential role for astrocytic Ca2+ signaling in regulating slow wave sleep. Im Titel ist "2+" hochgestellt Gesehen am 02.09.2020 |
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Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake and naturally sleeping mice while monitoring neuronal Ca2+ activity, brain rhythms and behavior. We show that astrocytic Ca2+ signals exhibit distinct features across the sleep-wake cycle and are reduced during sleep compared to wakefulness. Moreover, an increase in astrocytic Ca2+ signaling precedes transitions from slow wave sleep to wakefulness, with a peak upon awakening exceeding the levels during whisking and locomotion. Finally, genetic ablation of an important astrocytic Ca2+ signaling pathway impairs slow wave sleep and results in an increased number of microarousals, abnormal brain rhythms, and an increased frequency of slow wave sleep state transitions and sleep spindles. Our findings demonstrate an essential role for astrocytic Ca2+ signaling in regulating slow wave sleep. Im Titel ist "2+" hochgestellt Gesehen am 02.09.2020 |
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Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake and naturally sleeping mice while monitoring neuronal Ca2+ activity, brain rhythms and behavior. We show that astrocytic Ca2+ signals exhibit distinct features across the sleep-wake cycle and are reduced during sleep compared to wakefulness. Moreover, an increase in astrocytic Ca2+ signaling precedes transitions from slow wave sleep to wakefulness, with a peak upon awakening exceeding the levels during whisking and locomotion. Finally, genetic ablation of an important astrocytic Ca2+ signaling pathway impairs slow wave sleep and results in an increased number of microarousals, abnormal brain rhythms, and an increased frequency of slow wave sleep state transitions and sleep spindles. Our findings demonstrate an essential role for astrocytic Ca2+ signaling in regulating slow wave sleep. Im Titel ist "2+" hochgestellt Gesehen am 02.09.2020 |
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Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake and naturally sleeping mice while monitoring neuronal Ca2+ activity, brain rhythms and behavior. We show that astrocytic Ca2+ signals exhibit distinct features across the sleep-wake cycle and are reduced during sleep compared to wakefulness. Moreover, an increase in astrocytic Ca2+ signaling precedes transitions from slow wave sleep to wakefulness, with a peak upon awakening exceeding the levels during whisking and locomotion. Finally, genetic ablation of an important astrocytic Ca2+ signaling pathway impairs slow wave sleep and results in an increased number of microarousals, abnormal brain rhythms, and an increased frequency of slow wave sleep state transitions and sleep spindles. 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