Safety of mechanical thrombectomy with combined intravenous thrombolysis in stroke treatment 4.5 to 9 hours from symptom onset
Background: An extended time window for intravenous thrombolysis (IVT) for acute stroke patients up to 9 hours from symptom onset has been established in recent trials, excluding patients who received mechanical thrombectomy (MT). We therefore investigated whether combined therapy with IVT and MT (I...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Reiff, Tilman [verfasserIn] Barthel, Oliver [verfasserIn] Ringleb, Peter A. [verfasserIn] Pfaff, Johannes - 1983- [verfasserIn] Mundiyanapurath, Sibu - 1981- [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
August 13, 2020 |
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| Anmerkung: |
Gesehen am 18.11.2020 |
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| Umfang: |
7 |
| Übergeordnetes Werk: |
Enthalten in: Journal of stroke and cerebrovascular diseases - New York, NY : Elsevier, 1991, 29(2020,11) Artikel-Nummer 105204, 7 Seiten |
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| Übergeordnetes Werk: |
volume:29 ; year:2020 ; number:11 ; extent:7 |
| Links: |
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| DOI / URN: |
10.1016/j.jstrokecerebrovasdis.2020.105204 |
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| Katalog-ID: |
1739001885 |
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| 245 | 1 | 0 | |a Safety of mechanical thrombectomy with combined intravenous thrombolysis in stroke treatment 4.5 to 9 hours from symptom onset |c Tilman Reiff, MD, MSc, Oliver Barthel, Peter Arthur Ringleb, MD, PhD, Johannes Pfaff, MD, PhD, and Sibu Mundiyanapurath, MD, PhD |
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| 520 | |a Background: An extended time window for intravenous thrombolysis (IVT) for acute stroke patients up to 9 hours from symptom onset has been established in recent trials, excluding patients who received mechanical thrombectomy (MT). We therefore investigated whether combined therapy with IVT and MT (IVT+MT) is safe in patients with ischemic stroke and large vessel occlusion (LVO) in an extended time window. Methods: We retrospectively analyzed patients with anterior circulation ischemic stroke and LVO who were treated within 4.5 to 9 hours after symptom onset using MT with or without IVT. Primary endpoint was the occurrence of any intracranial hemorrhage (ICH). Multivariable logistic regression was used to adjust for potential confounders. Results: In total, 168 patients were included in the study, 44 (26%) were treated with IVT+ MT. 133 (79%) patients had a M1-/distal carotid artery occlusion. Median ASPECT-Score was 8 (IQR 7-10) and complete reperfusion (mTICI 2b-3) was achieved in 132 (79%) patients. 18 (41%) of the patients in the IVT+MT group developed any ICH vs. 45 (36%) patients in the direct MT group (p=0.587). Symptomatic ICH occurred in 5 (11%) patients with IVT+MT vs. 8 (6%) patients receiving direct MT (p=0.295). In multivariable analysis, IVT+MT was not an independent predictor of ICH (adjusted for NIHSS, degree of reperfusion, symptom-onset-to-treatment time and therapy with tirofiban; OR 0.95 [95% CI 0.43-2.08], p=0.896). Conclusion Mechanical thrombectomy in stroke patients seems to be safe with combined intravenous thrombolysis within 4.5 to 9 hours after onset as it did not significantly increase the risk for intracranial hemorrhage. | ||
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10.1016/j.jstrokecerebrovasdis.2020.105204 doi (DE-627)1739001885 (DE-599)KXP1739001885 (OCoLC)1341377736 DE-627 ger DE-627 rda eng Reiff, Tilman verfasserin (DE-588)1062797728 (DE-627)806943742 (DE-576)420213643 aut Safety of mechanical thrombectomy with combined intravenous thrombolysis in stroke treatment 4.5 to 9 hours from symptom onset Tilman Reiff, MD, MSc, Oliver Barthel, Peter Arthur Ringleb, MD, PhD, Johannes Pfaff, MD, PhD, and Sibu Mundiyanapurath, MD, PhD August 13, 2020 7 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 18.11.2020 Background: An extended time window for intravenous thrombolysis (IVT) for acute stroke patients up to 9 hours from symptom onset has been established in recent trials, excluding patients who received mechanical thrombectomy (MT). We therefore investigated whether combined therapy with IVT and MT (IVT+MT) is safe in patients with ischemic stroke and large vessel occlusion (LVO) in an extended time window. Methods: We retrospectively analyzed patients with anterior circulation ischemic stroke and LVO who were treated within 4.5 to 9 hours after symptom onset using MT with or without IVT. Primary endpoint was the occurrence of any intracranial hemorrhage (ICH). Multivariable logistic regression was used to adjust for potential confounders. Results: In total, 168 patients were included in the study, 44 (26%) were treated with IVT+ MT. 133 (79%) patients had a M1-/distal carotid artery occlusion. Median ASPECT-Score was 8 (IQR 7-10) and complete reperfusion (mTICI 2b-3) was achieved in 132 (79%) patients. 18 (41%) of the patients in the IVT+MT group developed any ICH vs. 45 (36%) patients in the direct MT group (p=0.587). Symptomatic ICH occurred in 5 (11%) patients with IVT+MT vs. 8 (6%) patients receiving direct MT (p=0.295). In multivariable analysis, IVT+MT was not an independent predictor of ICH (adjusted for NIHSS, degree of reperfusion, symptom-onset-to-treatment time and therapy with tirofiban; OR 0.95 [95% CI 0.43-2.08], p=0.896). Conclusion Mechanical thrombectomy in stroke patients seems to be safe with combined intravenous thrombolysis within 4.5 to 9 hours after onset as it did not significantly increase the risk for intracranial hemorrhage. Barthel, Oliver verfasserin (DE-588)1206259582 (DE-627)1692248278 aut Ringleb, Peter A. verfasserin (DE-588)1032676175 (DE-627)73863364X (DE-576)172917743 aut Pfaff, Johannes 1983- verfasserin (DE-588)14226718X (DE-627)704185598 (DE-576)329375318 aut Mundiyanapurath, Sibu 1981- verfasserin (DE-588)141949023 (DE-627)704103419 (DE-576)325724741 aut Enthalten in Journal of stroke and cerebrovascular diseases New York, NY : Elsevier, 1991 29(2020,11) Artikel-Nummer 105204, 7 Seiten Online-Ressource (DE-627)332166503 (DE-600)2052957-0 (DE-576)271585501 1532-8511 nnns volume:29 year:2020 number:11 extent:7 https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105204 Verlag Resolving-System lizenzpflichtig Volltext https://www.strokejournal.org/article/S1052-3057(20)30622-4/abstract Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 29 2020 11 7 29(2020,11) Artikel-Nummer 105204, 7 Seiten 2013 01 DE-16-250 3806567182 00 --%%-- --%%-- --%%-- --%%-- l01 18-11-20 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_5 2013 01 DE-16-250 03 s s_7 2013 01 DE-16-250 04 p (DE-627)1485165415 Reiff, Tilman 2013 01 DE-16-250 04 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1692248359 Barthel, Oliver 2013 01 DE-16-250 05 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1450182887 Ringleb, Peter A. 2013 01 DE-16-250 06 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_3 2013 01 DE-16-250 07 p (DE-627)1498361358 Pfaff, Johannes 2013 01 DE-16-250 07 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_4 2013 01 DE-16-250 08 p (DE-627)1498298656 Mundiyanapurath, Sibu 2013 01 DE-16-250 08 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_5 |
| spelling |
10.1016/j.jstrokecerebrovasdis.2020.105204 doi (DE-627)1739001885 (DE-599)KXP1739001885 (OCoLC)1341377736 DE-627 ger DE-627 rda eng Reiff, Tilman verfasserin (DE-588)1062797728 (DE-627)806943742 (DE-576)420213643 aut Safety of mechanical thrombectomy with combined intravenous thrombolysis in stroke treatment 4.5 to 9 hours from symptom onset Tilman Reiff, MD, MSc, Oliver Barthel, Peter Arthur Ringleb, MD, PhD, Johannes Pfaff, MD, PhD, and Sibu Mundiyanapurath, MD, PhD August 13, 2020 7 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 18.11.2020 Background: An extended time window for intravenous thrombolysis (IVT) for acute stroke patients up to 9 hours from symptom onset has been established in recent trials, excluding patients who received mechanical thrombectomy (MT). We therefore investigated whether combined therapy with IVT and MT (IVT+MT) is safe in patients with ischemic stroke and large vessel occlusion (LVO) in an extended time window. Methods: We retrospectively analyzed patients with anterior circulation ischemic stroke and LVO who were treated within 4.5 to 9 hours after symptom onset using MT with or without IVT. Primary endpoint was the occurrence of any intracranial hemorrhage (ICH). Multivariable logistic regression was used to adjust for potential confounders. Results: In total, 168 patients were included in the study, 44 (26%) were treated with IVT+ MT. 133 (79%) patients had a M1-/distal carotid artery occlusion. Median ASPECT-Score was 8 (IQR 7-10) and complete reperfusion (mTICI 2b-3) was achieved in 132 (79%) patients. 18 (41%) of the patients in the IVT+MT group developed any ICH vs. 45 (36%) patients in the direct MT group (p=0.587). Symptomatic ICH occurred in 5 (11%) patients with IVT+MT vs. 8 (6%) patients receiving direct MT (p=0.295). In multivariable analysis, IVT+MT was not an independent predictor of ICH (adjusted for NIHSS, degree of reperfusion, symptom-onset-to-treatment time and therapy with tirofiban; OR 0.95 [95% CI 0.43-2.08], p=0.896). Conclusion Mechanical thrombectomy in stroke patients seems to be safe with combined intravenous thrombolysis within 4.5 to 9 hours after onset as it did not significantly increase the risk for intracranial hemorrhage. Barthel, Oliver verfasserin (DE-588)1206259582 (DE-627)1692248278 aut Ringleb, Peter A. verfasserin (DE-588)1032676175 (DE-627)73863364X (DE-576)172917743 aut Pfaff, Johannes 1983- verfasserin (DE-588)14226718X (DE-627)704185598 (DE-576)329375318 aut Mundiyanapurath, Sibu 1981- verfasserin (DE-588)141949023 (DE-627)704103419 (DE-576)325724741 aut Enthalten in Journal of stroke and cerebrovascular diseases New York, NY : Elsevier, 1991 29(2020,11) Artikel-Nummer 105204, 7 Seiten Online-Ressource (DE-627)332166503 (DE-600)2052957-0 (DE-576)271585501 1532-8511 nnns volume:29 year:2020 number:11 extent:7 https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105204 Verlag Resolving-System lizenzpflichtig Volltext https://www.strokejournal.org/article/S1052-3057(20)30622-4/abstract Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 29 2020 11 7 29(2020,11) Artikel-Nummer 105204, 7 Seiten 2013 01 DE-16-250 3806567182 00 --%%-- --%%-- --%%-- --%%-- l01 18-11-20 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_5 2013 01 DE-16-250 03 s s_7 2013 01 DE-16-250 04 p (DE-627)1485165415 Reiff, Tilman 2013 01 DE-16-250 04 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1692248359 Barthel, Oliver 2013 01 DE-16-250 05 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1450182887 Ringleb, Peter A. 2013 01 DE-16-250 06 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_3 2013 01 DE-16-250 07 p (DE-627)1498361358 Pfaff, Johannes 2013 01 DE-16-250 07 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_4 2013 01 DE-16-250 08 p (DE-627)1498298656 Mundiyanapurath, Sibu 2013 01 DE-16-250 08 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_5 |
| allfields_unstemmed |
10.1016/j.jstrokecerebrovasdis.2020.105204 doi (DE-627)1739001885 (DE-599)KXP1739001885 (OCoLC)1341377736 DE-627 ger DE-627 rda eng Reiff, Tilman verfasserin (DE-588)1062797728 (DE-627)806943742 (DE-576)420213643 aut Safety of mechanical thrombectomy with combined intravenous thrombolysis in stroke treatment 4.5 to 9 hours from symptom onset Tilman Reiff, MD, MSc, Oliver Barthel, Peter Arthur Ringleb, MD, PhD, Johannes Pfaff, MD, PhD, and Sibu Mundiyanapurath, MD, PhD August 13, 2020 7 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 18.11.2020 Background: An extended time window for intravenous thrombolysis (IVT) for acute stroke patients up to 9 hours from symptom onset has been established in recent trials, excluding patients who received mechanical thrombectomy (MT). We therefore investigated whether combined therapy with IVT and MT (IVT+MT) is safe in patients with ischemic stroke and large vessel occlusion (LVO) in an extended time window. Methods: We retrospectively analyzed patients with anterior circulation ischemic stroke and LVO who were treated within 4.5 to 9 hours after symptom onset using MT with or without IVT. Primary endpoint was the occurrence of any intracranial hemorrhage (ICH). Multivariable logistic regression was used to adjust for potential confounders. Results: In total, 168 patients were included in the study, 44 (26%) were treated with IVT+ MT. 133 (79%) patients had a M1-/distal carotid artery occlusion. Median ASPECT-Score was 8 (IQR 7-10) and complete reperfusion (mTICI 2b-3) was achieved in 132 (79%) patients. 18 (41%) of the patients in the IVT+MT group developed any ICH vs. 45 (36%) patients in the direct MT group (p=0.587). Symptomatic ICH occurred in 5 (11%) patients with IVT+MT vs. 8 (6%) patients receiving direct MT (p=0.295). In multivariable analysis, IVT+MT was not an independent predictor of ICH (adjusted for NIHSS, degree of reperfusion, symptom-onset-to-treatment time and therapy with tirofiban; OR 0.95 [95% CI 0.43-2.08], p=0.896). Conclusion Mechanical thrombectomy in stroke patients seems to be safe with combined intravenous thrombolysis within 4.5 to 9 hours after onset as it did not significantly increase the risk for intracranial hemorrhage. Barthel, Oliver verfasserin (DE-588)1206259582 (DE-627)1692248278 aut Ringleb, Peter A. verfasserin (DE-588)1032676175 (DE-627)73863364X (DE-576)172917743 aut Pfaff, Johannes 1983- verfasserin (DE-588)14226718X (DE-627)704185598 (DE-576)329375318 aut Mundiyanapurath, Sibu 1981- verfasserin (DE-588)141949023 (DE-627)704103419 (DE-576)325724741 aut Enthalten in Journal of stroke and cerebrovascular diseases New York, NY : Elsevier, 1991 29(2020,11) Artikel-Nummer 105204, 7 Seiten Online-Ressource (DE-627)332166503 (DE-600)2052957-0 (DE-576)271585501 1532-8511 nnns volume:29 year:2020 number:11 extent:7 https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105204 Verlag Resolving-System lizenzpflichtig Volltext https://www.strokejournal.org/article/S1052-3057(20)30622-4/abstract Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 29 2020 11 7 29(2020,11) Artikel-Nummer 105204, 7 Seiten 2013 01 DE-16-250 3806567182 00 --%%-- --%%-- --%%-- --%%-- l01 18-11-20 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_5 2013 01 DE-16-250 03 s s_7 2013 01 DE-16-250 04 p (DE-627)1485165415 Reiff, Tilman 2013 01 DE-16-250 04 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1692248359 Barthel, Oliver 2013 01 DE-16-250 05 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1450182887 Ringleb, Peter A. 2013 01 DE-16-250 06 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_3 2013 01 DE-16-250 07 p (DE-627)1498361358 Pfaff, Johannes 2013 01 DE-16-250 07 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_4 2013 01 DE-16-250 08 p (DE-627)1498298656 Mundiyanapurath, Sibu 2013 01 DE-16-250 08 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_5 |
| allfieldsGer |
10.1016/j.jstrokecerebrovasdis.2020.105204 doi (DE-627)1739001885 (DE-599)KXP1739001885 (OCoLC)1341377736 DE-627 ger DE-627 rda eng Reiff, Tilman verfasserin (DE-588)1062797728 (DE-627)806943742 (DE-576)420213643 aut Safety of mechanical thrombectomy with combined intravenous thrombolysis in stroke treatment 4.5 to 9 hours from symptom onset Tilman Reiff, MD, MSc, Oliver Barthel, Peter Arthur Ringleb, MD, PhD, Johannes Pfaff, MD, PhD, and Sibu Mundiyanapurath, MD, PhD August 13, 2020 7 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 18.11.2020 Background: An extended time window for intravenous thrombolysis (IVT) for acute stroke patients up to 9 hours from symptom onset has been established in recent trials, excluding patients who received mechanical thrombectomy (MT). We therefore investigated whether combined therapy with IVT and MT (IVT+MT) is safe in patients with ischemic stroke and large vessel occlusion (LVO) in an extended time window. Methods: We retrospectively analyzed patients with anterior circulation ischemic stroke and LVO who were treated within 4.5 to 9 hours after symptom onset using MT with or without IVT. Primary endpoint was the occurrence of any intracranial hemorrhage (ICH). Multivariable logistic regression was used to adjust for potential confounders. Results: In total, 168 patients were included in the study, 44 (26%) were treated with IVT+ MT. 133 (79%) patients had a M1-/distal carotid artery occlusion. Median ASPECT-Score was 8 (IQR 7-10) and complete reperfusion (mTICI 2b-3) was achieved in 132 (79%) patients. 18 (41%) of the patients in the IVT+MT group developed any ICH vs. 45 (36%) patients in the direct MT group (p=0.587). Symptomatic ICH occurred in 5 (11%) patients with IVT+MT vs. 8 (6%) patients receiving direct MT (p=0.295). In multivariable analysis, IVT+MT was not an independent predictor of ICH (adjusted for NIHSS, degree of reperfusion, symptom-onset-to-treatment time and therapy with tirofiban; OR 0.95 [95% CI 0.43-2.08], p=0.896). Conclusion Mechanical thrombectomy in stroke patients seems to be safe with combined intravenous thrombolysis within 4.5 to 9 hours after onset as it did not significantly increase the risk for intracranial hemorrhage. Barthel, Oliver verfasserin (DE-588)1206259582 (DE-627)1692248278 aut Ringleb, Peter A. verfasserin (DE-588)1032676175 (DE-627)73863364X (DE-576)172917743 aut Pfaff, Johannes 1983- verfasserin (DE-588)14226718X (DE-627)704185598 (DE-576)329375318 aut Mundiyanapurath, Sibu 1981- verfasserin (DE-588)141949023 (DE-627)704103419 (DE-576)325724741 aut Enthalten in Journal of stroke and cerebrovascular diseases New York, NY : Elsevier, 1991 29(2020,11) Artikel-Nummer 105204, 7 Seiten Online-Ressource (DE-627)332166503 (DE-600)2052957-0 (DE-576)271585501 1532-8511 nnns volume:29 year:2020 number:11 extent:7 https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105204 Verlag Resolving-System lizenzpflichtig Volltext https://www.strokejournal.org/article/S1052-3057(20)30622-4/abstract Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 29 2020 11 7 29(2020,11) Artikel-Nummer 105204, 7 Seiten 2013 01 DE-16-250 3806567182 00 --%%-- --%%-- --%%-- --%%-- l01 18-11-20 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_5 2013 01 DE-16-250 03 s s_7 2013 01 DE-16-250 04 p (DE-627)1485165415 Reiff, Tilman 2013 01 DE-16-250 04 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1692248359 Barthel, Oliver 2013 01 DE-16-250 05 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1450182887 Ringleb, Peter A. 2013 01 DE-16-250 06 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_3 2013 01 DE-16-250 07 p (DE-627)1498361358 Pfaff, Johannes 2013 01 DE-16-250 07 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_4 2013 01 DE-16-250 08 p (DE-627)1498298656 Mundiyanapurath, Sibu 2013 01 DE-16-250 08 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_5 |
| allfieldsSound |
10.1016/j.jstrokecerebrovasdis.2020.105204 doi (DE-627)1739001885 (DE-599)KXP1739001885 (OCoLC)1341377736 DE-627 ger DE-627 rda eng Reiff, Tilman verfasserin (DE-588)1062797728 (DE-627)806943742 (DE-576)420213643 aut Safety of mechanical thrombectomy with combined intravenous thrombolysis in stroke treatment 4.5 to 9 hours from symptom onset Tilman Reiff, MD, MSc, Oliver Barthel, Peter Arthur Ringleb, MD, PhD, Johannes Pfaff, MD, PhD, and Sibu Mundiyanapurath, MD, PhD August 13, 2020 7 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 18.11.2020 Background: An extended time window for intravenous thrombolysis (IVT) for acute stroke patients up to 9 hours from symptom onset has been established in recent trials, excluding patients who received mechanical thrombectomy (MT). We therefore investigated whether combined therapy with IVT and MT (IVT+MT) is safe in patients with ischemic stroke and large vessel occlusion (LVO) in an extended time window. Methods: We retrospectively analyzed patients with anterior circulation ischemic stroke and LVO who were treated within 4.5 to 9 hours after symptom onset using MT with or without IVT. Primary endpoint was the occurrence of any intracranial hemorrhage (ICH). Multivariable logistic regression was used to adjust for potential confounders. Results: In total, 168 patients were included in the study, 44 (26%) were treated with IVT+ MT. 133 (79%) patients had a M1-/distal carotid artery occlusion. Median ASPECT-Score was 8 (IQR 7-10) and complete reperfusion (mTICI 2b-3) was achieved in 132 (79%) patients. 18 (41%) of the patients in the IVT+MT group developed any ICH vs. 45 (36%) patients in the direct MT group (p=0.587). Symptomatic ICH occurred in 5 (11%) patients with IVT+MT vs. 8 (6%) patients receiving direct MT (p=0.295). In multivariable analysis, IVT+MT was not an independent predictor of ICH (adjusted for NIHSS, degree of reperfusion, symptom-onset-to-treatment time and therapy with tirofiban; OR 0.95 [95% CI 0.43-2.08], p=0.896). Conclusion Mechanical thrombectomy in stroke patients seems to be safe with combined intravenous thrombolysis within 4.5 to 9 hours after onset as it did not significantly increase the risk for intracranial hemorrhage. Barthel, Oliver verfasserin (DE-588)1206259582 (DE-627)1692248278 aut Ringleb, Peter A. verfasserin (DE-588)1032676175 (DE-627)73863364X (DE-576)172917743 aut Pfaff, Johannes 1983- verfasserin (DE-588)14226718X (DE-627)704185598 (DE-576)329375318 aut Mundiyanapurath, Sibu 1981- verfasserin (DE-588)141949023 (DE-627)704103419 (DE-576)325724741 aut Enthalten in Journal of stroke and cerebrovascular diseases New York, NY : Elsevier, 1991 29(2020,11) Artikel-Nummer 105204, 7 Seiten Online-Ressource (DE-627)332166503 (DE-600)2052957-0 (DE-576)271585501 1532-8511 nnns volume:29 year:2020 number:11 extent:7 https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105204 Verlag Resolving-System lizenzpflichtig Volltext https://www.strokejournal.org/article/S1052-3057(20)30622-4/abstract Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 29 2020 11 7 29(2020,11) Artikel-Nummer 105204, 7 Seiten 2013 01 DE-16-250 3806567182 00 --%%-- --%%-- --%%-- --%%-- l01 18-11-20 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_5 2013 01 DE-16-250 03 s s_7 2013 01 DE-16-250 04 p (DE-627)1485165415 Reiff, Tilman 2013 01 DE-16-250 04 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1692248359 Barthel, Oliver 2013 01 DE-16-250 05 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1450182887 Ringleb, Peter A. 2013 01 DE-16-250 06 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_3 2013 01 DE-16-250 07 p (DE-627)1498361358 Pfaff, Johannes 2013 01 DE-16-250 07 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_4 2013 01 DE-16-250 08 p (DE-627)1498298656 Mundiyanapurath, Sibu 2013 01 DE-16-250 08 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_5 |
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We therefore investigated whether combined therapy with IVT and MT (IVT+MT) is safe in patients with ischemic stroke and large vessel occlusion (LVO) in an extended time window. Methods: We retrospectively analyzed patients with anterior circulation ischemic stroke and LVO who were treated within 4.5 to 9 hours after symptom onset using MT with or without IVT. Primary endpoint was the occurrence of any intracranial hemorrhage (ICH). Multivariable logistic regression was used to adjust for potential confounders. Results: In total, 168 patients were included in the study, 44 (26%) were treated with IVT+ MT. 133 (79%) patients had a M1-/distal carotid artery occlusion. Median ASPECT-Score was 8 (IQR 7-10) and complete reperfusion (mTICI 2b-3) was achieved in 132 (79%) patients. 18 (41%) of the patients in the IVT+MT group developed any ICH vs. 45 (36%) patients in the direct MT group (p=0.587). Symptomatic ICH occurred in 5 (11%) patients with IVT+MT vs. 8 (6%) patients receiving direct MT (p=0.295). In multivariable analysis, IVT+MT was not an independent predictor of ICH (adjusted for NIHSS, degree of reperfusion, symptom-onset-to-treatment time and therapy with tirofiban; OR 0.95 [95% CI 0.43-2.08], p=0.896). 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Safety of mechanical thrombectomy with combined intravenous thrombolysis in stroke treatment 4.5 to 9 hours from symptom onset Tilman Reiff, MD, MSc, Oliver Barthel, Peter Arthur Ringleb, MD, PhD, Johannes Pfaff, MD, PhD, and Sibu Mundiyanapurath, MD, PhD |
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safety of mechanical thrombectomy with combined intravenous thrombolysis in stroke treatment 4.5 to 9 hours from symptom onset |
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Safety of mechanical thrombectomy with combined intravenous thrombolysis in stroke treatment 4.5 to 9 hours from symptom onset |
| abstract |
Background: An extended time window for intravenous thrombolysis (IVT) for acute stroke patients up to 9 hours from symptom onset has been established in recent trials, excluding patients who received mechanical thrombectomy (MT). We therefore investigated whether combined therapy with IVT and MT (IVT+MT) is safe in patients with ischemic stroke and large vessel occlusion (LVO) in an extended time window. Methods: We retrospectively analyzed patients with anterior circulation ischemic stroke and LVO who were treated within 4.5 to 9 hours after symptom onset using MT with or without IVT. Primary endpoint was the occurrence of any intracranial hemorrhage (ICH). Multivariable logistic regression was used to adjust for potential confounders. Results: In total, 168 patients were included in the study, 44 (26%) were treated with IVT+ MT. 133 (79%) patients had a M1-/distal carotid artery occlusion. Median ASPECT-Score was 8 (IQR 7-10) and complete reperfusion (mTICI 2b-3) was achieved in 132 (79%) patients. 18 (41%) of the patients in the IVT+MT group developed any ICH vs. 45 (36%) patients in the direct MT group (p=0.587). Symptomatic ICH occurred in 5 (11%) patients with IVT+MT vs. 8 (6%) patients receiving direct MT (p=0.295). In multivariable analysis, IVT+MT was not an independent predictor of ICH (adjusted for NIHSS, degree of reperfusion, symptom-onset-to-treatment time and therapy with tirofiban; OR 0.95 [95% CI 0.43-2.08], p=0.896). Conclusion Mechanical thrombectomy in stroke patients seems to be safe with combined intravenous thrombolysis within 4.5 to 9 hours after onset as it did not significantly increase the risk for intracranial hemorrhage. Gesehen am 18.11.2020 |
| abstractGer |
Background: An extended time window for intravenous thrombolysis (IVT) for acute stroke patients up to 9 hours from symptom onset has been established in recent trials, excluding patients who received mechanical thrombectomy (MT). We therefore investigated whether combined therapy with IVT and MT (IVT+MT) is safe in patients with ischemic stroke and large vessel occlusion (LVO) in an extended time window. Methods: We retrospectively analyzed patients with anterior circulation ischemic stroke and LVO who were treated within 4.5 to 9 hours after symptom onset using MT with or without IVT. Primary endpoint was the occurrence of any intracranial hemorrhage (ICH). Multivariable logistic regression was used to adjust for potential confounders. Results: In total, 168 patients were included in the study, 44 (26%) were treated with IVT+ MT. 133 (79%) patients had a M1-/distal carotid artery occlusion. Median ASPECT-Score was 8 (IQR 7-10) and complete reperfusion (mTICI 2b-3) was achieved in 132 (79%) patients. 18 (41%) of the patients in the IVT+MT group developed any ICH vs. 45 (36%) patients in the direct MT group (p=0.587). Symptomatic ICH occurred in 5 (11%) patients with IVT+MT vs. 8 (6%) patients receiving direct MT (p=0.295). In multivariable analysis, IVT+MT was not an independent predictor of ICH (adjusted for NIHSS, degree of reperfusion, symptom-onset-to-treatment time and therapy with tirofiban; OR 0.95 [95% CI 0.43-2.08], p=0.896). Conclusion Mechanical thrombectomy in stroke patients seems to be safe with combined intravenous thrombolysis within 4.5 to 9 hours after onset as it did not significantly increase the risk for intracranial hemorrhage. Gesehen am 18.11.2020 |
| abstract_unstemmed |
Background: An extended time window for intravenous thrombolysis (IVT) for acute stroke patients up to 9 hours from symptom onset has been established in recent trials, excluding patients who received mechanical thrombectomy (MT). We therefore investigated whether combined therapy with IVT and MT (IVT+MT) is safe in patients with ischemic stroke and large vessel occlusion (LVO) in an extended time window. Methods: We retrospectively analyzed patients with anterior circulation ischemic stroke and LVO who were treated within 4.5 to 9 hours after symptom onset using MT with or without IVT. Primary endpoint was the occurrence of any intracranial hemorrhage (ICH). Multivariable logistic regression was used to adjust for potential confounders. Results: In total, 168 patients were included in the study, 44 (26%) were treated with IVT+ MT. 133 (79%) patients had a M1-/distal carotid artery occlusion. Median ASPECT-Score was 8 (IQR 7-10) and complete reperfusion (mTICI 2b-3) was achieved in 132 (79%) patients. 18 (41%) of the patients in the IVT+MT group developed any ICH vs. 45 (36%) patients in the direct MT group (p=0.587). Symptomatic ICH occurred in 5 (11%) patients with IVT+MT vs. 8 (6%) patients receiving direct MT (p=0.295). In multivariable analysis, IVT+MT was not an independent predictor of ICH (adjusted for NIHSS, degree of reperfusion, symptom-onset-to-treatment time and therapy with tirofiban; OR 0.95 [95% CI 0.43-2.08], p=0.896). Conclusion Mechanical thrombectomy in stroke patients seems to be safe with combined intravenous thrombolysis within 4.5 to 9 hours after onset as it did not significantly increase the risk for intracranial hemorrhage. Gesehen am 18.11.2020 |
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Safety of mechanical thrombectomy with combined intravenous thrombolysis in stroke treatment 4.5 to 9 hours from symptom onset |
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https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105204 https://www.strokejournal.org/article/S1052-3057(20)30622-4/abstract |
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