Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants : a Prospective Lynch Syndrome Database report
Purpose - This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. - Methods - The Prospective Lynch Syndrome Database (PLSD) was used to inves...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
17 March 2021 |
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| Schlagwörter: |
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| Anmerkung: |
Gesehen am 23.08.2021 |
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| Umfang: |
10 |
| Übergeordnetes Werk: |
Enthalten in: European journal of cancer - Amsterdam [u.a.] : Elsevier, 1992, 148(2021), Seite 124-133 |
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| Übergeordnetes Werk: |
volume:148 ; year:2021 ; pages:124-133 ; extent:10 |
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| DOI / URN: |
10.1016/j.ejca.2021.02.022 |
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| Katalog-ID: |
1767685572 |
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| 245 | 1 | 0 | |a Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants |b a Prospective Lynch Syndrome Database report |c Toni T. Seppälä, Mev Dominguez-Valentin, Emma J. Crosbie, Christoph Engel, Stefan Aretz, Finlay Macrae, Ingrid Winship, Gabriel Capella, Huw Thomas, Eivind Hovig, Maartje Nielsen, Rolf H. Sijmons, Lucio Bertario, Bernardo Bonanni, Maria G. Tibiletti, Giulia M. Cavestro, Miriam Mints, Nathan Gluck, Lior Katz, Karl Heinimann, Carlos A. Vaccaro, Kate Green, Fiona Lalloo, James Hill, Wolff Schmiegel, Deepak Vangala, Claudia Perne, Hans-Georg Strauß, Johanna Tecklenburg, Elke Holinski-Feder, Verena Steinke-Lange, Jukka-Pekka Mecklin, John-Paul Plazzer, Marta Pineda, Matilde Navarro, Joan B. Vida, Revital Kariv, Guy Rosner, Tamara A. Piñero, Walter Pavicic, Pablo Kalfayan, Sanne W. ten Broeke, Mark A. Jenkins, Lone Sunde, Inge Bernstein, John Burn, Marc Greenblatt, Wouter H. de Vos tot Nederveen Cappel, Adriana Della Valle, Francisco Lopez-Koestner, Karin Alvarez, Reinhard Büttner, Heike Görgens, Monika Morak, Stefanie Holzapfel, Robert Hüneburg, Magnus von Knebel Doeberitz, Markus Loeffler, Silke Redler, Jürgen Weitz, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, John L. Hopper, Aung K. Win, Noralane M. Lindor, Steven Gallinger, Loïc Le Marchand, Polly A. Newcomb, Jane C. Figueiredo, Stephen N. Thibodeau, Christina Therkildsen, Karin A.W. Wadt, Marian J.E. Mourits, Zohreh Ketabi, Oliver G. Denton, Einar A. Rødland, Hans Vasen, Florencia Neffa, Patricia Esperon, Douglas Tjandra, Gabriela Möslein, Erik Rokkones, Julian R. Sampson, D.G. Evans, Pål Møller |
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| 520 | |a Purpose - This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. - Methods - The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. - Results - Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. - Conclusion - Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene- and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syndrome to improve outcomes. | ||
| 650 | 4 | |a Endometrial cancer | |
| 650 | 4 | |a Hysterectomy | |
| 650 | 4 | |a Lynch syndrome | |
| 650 | 4 | |a Oophorectomy | |
| 650 | 4 | |a Ovarian cancer | |
| 650 | 4 | |a Risk-reducing surgery | |
| 700 | 1 | |a Dominguez-Valentin, Mev |e verfasserin |4 aut | |
| 700 | 1 | |a Crosbie, Emma J. |e verfasserin |4 aut | |
| 700 | 1 | |a Engel, Christoph |e verfasserin |4 aut | |
| 700 | 1 | |a Aretz, Stefan |e verfasserin |4 aut | |
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| 700 | 1 | |a Winship, Ingrid |e verfasserin |4 aut | |
| 700 | 1 | |a Capella, Gabriel |e verfasserin |4 aut | |
| 700 | 1 | |a Thomas, Huw |e verfasserin |4 aut | |
| 700 | 1 | |a Hovig, Eivind |e verfasserin |4 aut | |
| 700 | 1 | |a Nielsen, Maartje |e verfasserin |4 aut | |
| 700 | 1 | |a Sijmons, Rolf H. |e verfasserin |4 aut | |
| 700 | 1 | |a Bertario, Lucio |e verfasserin |4 aut | |
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| 700 | 1 | |a Vida, Joan B. |e verfasserin |4 aut | |
| 700 | 1 | |a Kariv, Revital |e verfasserin |4 aut | |
| 700 | 1 | |a Rosner, Guy |e verfasserin |4 aut | |
| 700 | 1 | |a Piñero, Tamara A. |e verfasserin |4 aut | |
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| 700 | 1 | |a Lepistö, Anna |e verfasserin |4 aut | |
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| 700 | 1 | |a Win, Aung K. |e verfasserin |4 aut | |
| 700 | 1 | |a Lindor, Noralane M. |e verfasserin |4 aut | |
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10.1016/j.ejca.2021.02.022 doi (DE-627)1767685572 (DE-599)KXP1767685572 (OCoLC)1341420921 DE-627 ger DE-627 rda eng Seppälä, Toni T. verfasserin (DE-588)1182620558 (DE-627)1662853734 aut Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants a Prospective Lynch Syndrome Database report Toni T. Seppälä, Mev Dominguez-Valentin, Emma J. Crosbie, Christoph Engel, Stefan Aretz, Finlay Macrae, Ingrid Winship, Gabriel Capella, Huw Thomas, Eivind Hovig, Maartje Nielsen, Rolf H. Sijmons, Lucio Bertario, Bernardo Bonanni, Maria G. Tibiletti, Giulia M. Cavestro, Miriam Mints, Nathan Gluck, Lior Katz, Karl Heinimann, Carlos A. Vaccaro, Kate Green, Fiona Lalloo, James Hill, Wolff Schmiegel, Deepak Vangala, Claudia Perne, Hans-Georg Strauß, Johanna Tecklenburg, Elke Holinski-Feder, Verena Steinke-Lange, Jukka-Pekka Mecklin, John-Paul Plazzer, Marta Pineda, Matilde Navarro, Joan B. Vida, Revital Kariv, Guy Rosner, Tamara A. Piñero, Walter Pavicic, Pablo Kalfayan, Sanne W. ten Broeke, Mark A. Jenkins, Lone Sunde, Inge Bernstein, John Burn, Marc Greenblatt, Wouter H. de Vos tot Nederveen Cappel, Adriana Della Valle, Francisco Lopez-Koestner, Karin Alvarez, Reinhard Büttner, Heike Görgens, Monika Morak, Stefanie Holzapfel, Robert Hüneburg, Magnus von Knebel Doeberitz, Markus Loeffler, Silke Redler, Jürgen Weitz, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, John L. Hopper, Aung K. Win, Noralane M. Lindor, Steven Gallinger, Loïc Le Marchand, Polly A. Newcomb, Jane C. Figueiredo, Stephen N. Thibodeau, Christina Therkildsen, Karin A.W. Wadt, Marian J.E. Mourits, Zohreh Ketabi, Oliver G. Denton, Einar A. Rødland, Hans Vasen, Florencia Neffa, Patricia Esperon, Douglas Tjandra, Gabriela Möslein, Erik Rokkones, Julian R. Sampson, D.G. Evans, Pål Møller 17 March 2021 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 23.08.2021 Purpose - This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. - Methods - The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. - Results - Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. - Conclusion - Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene- and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syndrome to improve outcomes. Endometrial cancer Hysterectomy Lynch syndrome Oophorectomy Ovarian cancer Risk-reducing surgery Dominguez-Valentin, Mev verfasserin aut Crosbie, Emma J. verfasserin aut Engel, Christoph verfasserin aut Aretz, Stefan verfasserin aut Macrae, Finlay verfasserin aut Winship, Ingrid verfasserin aut Capella, Gabriel verfasserin aut Thomas, Huw verfasserin aut Hovig, Eivind verfasserin aut Nielsen, Maartje verfasserin aut Sijmons, Rolf H. verfasserin aut Bertario, Lucio verfasserin aut Bonanni, Bernardo verfasserin aut Tibiletti, Maria G. verfasserin aut Cavestro, Giulia M. verfasserin aut Mints, Miriam verfasserin aut Gluck, Nathan verfasserin aut Katz, Lior verfasserin aut Heinimann, Karl verfasserin aut Vaccaro, Carlos A. verfasserin aut Green, Kate verfasserin aut Lalloo, Fiona verfasserin aut Hill, James verfasserin aut Schmiegel, Wolff verfasserin aut Vangala, Deepak verfasserin aut Perne, Claudia verfasserin aut Strauß, Hans-Georg verfasserin aut Tecklenburg, Johanna verfasserin aut Holinski-Feder, Elke verfasserin aut Steinke-Lange, Verena verfasserin aut Mecklin, Jukka-Pekka verfasserin aut Plazzer, John-Paul verfasserin aut Pineda, Marta verfasserin aut Navarro, Matilde verfasserin aut Vida, Joan B. verfasserin aut Kariv, Revital verfasserin aut Rosner, Guy verfasserin aut Piñero, Tamara A. verfasserin aut Pavicic, Walter verfasserin aut Kalfayan, Pablo verfasserin aut Ten Broeke, Sanne W. verfasserin (DE-588)1185706615 (DE-627)1665059923 aut Jenkins, Mark A. verfasserin aut Sunde, Lone verfasserin aut Bernstein, Inge verfasserin aut Burn, John verfasserin aut Greenblatt, Marc verfasserin aut de Vos tot Nederveen Cappel, Wouter H. verfasserin aut Della Valle, Adriana verfasserin aut Lopez-Koestner, Francisco verfasserin aut Alvarez, Karin verfasserin aut Büttner, Reinhard verfasserin aut Görgens, Heike verfasserin aut Morak, Monika verfasserin aut Holzapfel, Stefanie verfasserin aut Hüneburg, Robert verfasserin aut Knebel Doeberitz, Magnus von verfasserin (DE-588)1022165291 (DE-627)71693289X (DE-576)364934239 aut Loeffler, Markus verfasserin aut Redler, Silke verfasserin aut Weitz, Jürgen verfasserin aut Pylvänäinen, Kirsi verfasserin aut Renkonen-Sinisalo, Laura verfasserin aut Lepistö, Anna verfasserin aut Hopper, John L. verfasserin aut Win, Aung K. verfasserin aut Lindor, Noralane M. verfasserin aut Gallinger, Steven verfasserin aut Le Marchand, Loïc verfasserin aut Newcomb, Polly A. verfasserin aut Figueiredo, Jane C. verfasserin aut Thibodeau, Stephen N. verfasserin aut Therkildsen, Christina verfasserin aut Wadt, Karin A. W. verfasserin aut Mourits, Marian J. E. verfasserin aut Ketabi, Zohreh verfasserin aut Denton, Oliver G. verfasserin aut Rødland, Einar A. verfasserin aut Vasen, Hans verfasserin aut Neffa, Florencia verfasserin aut Esperon, Patricia verfasserin aut Tjandra, Douglas verfasserin aut Möslein, Gabriela verfasserin aut Rokkones, Erik verfasserin aut Sampson, Julian R. verfasserin aut Evans, D. G. verfasserin aut Møller, Pål verfasserin aut Enthalten in European journal of cancer Amsterdam [u.a.] : Elsevier, 1992 148(2021), Seite 124-133 (DE-627)266883400 (DE-600)1468190-0 (DE-576)090954173 1879-0852 nnns volume:148 year:2021 pages:124-133 extent:10 https://doi.org/10.1016/j.ejca.2021.02.022 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0959804921001052 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 148 2021 124-133 10 2013 01 DE-16-250 3970785774 00 --%%-- --%%-- --%%-- --%%-- l01 23-08-21 2013 01 DE-16-250 00 s hd2021 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_87 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1435319745 Knebel Doeberitz, Magnus von 2013 01 DE-16-250 04 k (DE-627)1416741658 Pathologisches Institut 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_58 |
| spelling |
10.1016/j.ejca.2021.02.022 doi (DE-627)1767685572 (DE-599)KXP1767685572 (OCoLC)1341420921 DE-627 ger DE-627 rda eng Seppälä, Toni T. verfasserin (DE-588)1182620558 (DE-627)1662853734 aut Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants a Prospective Lynch Syndrome Database report Toni T. Seppälä, Mev Dominguez-Valentin, Emma J. Crosbie, Christoph Engel, Stefan Aretz, Finlay Macrae, Ingrid Winship, Gabriel Capella, Huw Thomas, Eivind Hovig, Maartje Nielsen, Rolf H. Sijmons, Lucio Bertario, Bernardo Bonanni, Maria G. Tibiletti, Giulia M. Cavestro, Miriam Mints, Nathan Gluck, Lior Katz, Karl Heinimann, Carlos A. Vaccaro, Kate Green, Fiona Lalloo, James Hill, Wolff Schmiegel, Deepak Vangala, Claudia Perne, Hans-Georg Strauß, Johanna Tecklenburg, Elke Holinski-Feder, Verena Steinke-Lange, Jukka-Pekka Mecklin, John-Paul Plazzer, Marta Pineda, Matilde Navarro, Joan B. Vida, Revital Kariv, Guy Rosner, Tamara A. Piñero, Walter Pavicic, Pablo Kalfayan, Sanne W. ten Broeke, Mark A. Jenkins, Lone Sunde, Inge Bernstein, John Burn, Marc Greenblatt, Wouter H. de Vos tot Nederveen Cappel, Adriana Della Valle, Francisco Lopez-Koestner, Karin Alvarez, Reinhard Büttner, Heike Görgens, Monika Morak, Stefanie Holzapfel, Robert Hüneburg, Magnus von Knebel Doeberitz, Markus Loeffler, Silke Redler, Jürgen Weitz, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, John L. Hopper, Aung K. Win, Noralane M. Lindor, Steven Gallinger, Loïc Le Marchand, Polly A. Newcomb, Jane C. Figueiredo, Stephen N. Thibodeau, Christina Therkildsen, Karin A.W. Wadt, Marian J.E. Mourits, Zohreh Ketabi, Oliver G. Denton, Einar A. Rødland, Hans Vasen, Florencia Neffa, Patricia Esperon, Douglas Tjandra, Gabriela Möslein, Erik Rokkones, Julian R. Sampson, D.G. Evans, Pål Møller 17 March 2021 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 23.08.2021 Purpose - This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. - Methods - The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. - Results - Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. - Conclusion - Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene- and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syndrome to improve outcomes. Endometrial cancer Hysterectomy Lynch syndrome Oophorectomy Ovarian cancer Risk-reducing surgery Dominguez-Valentin, Mev verfasserin aut Crosbie, Emma J. verfasserin aut Engel, Christoph verfasserin aut Aretz, Stefan verfasserin aut Macrae, Finlay verfasserin aut Winship, Ingrid verfasserin aut Capella, Gabriel verfasserin aut Thomas, Huw verfasserin aut Hovig, Eivind verfasserin aut Nielsen, Maartje verfasserin aut Sijmons, Rolf H. verfasserin aut Bertario, Lucio verfasserin aut Bonanni, Bernardo verfasserin aut Tibiletti, Maria G. verfasserin aut Cavestro, Giulia M. verfasserin aut Mints, Miriam verfasserin aut Gluck, Nathan verfasserin aut Katz, Lior verfasserin aut Heinimann, Karl verfasserin aut Vaccaro, Carlos A. verfasserin aut Green, Kate verfasserin aut Lalloo, Fiona verfasserin aut Hill, James verfasserin aut Schmiegel, Wolff verfasserin aut Vangala, Deepak verfasserin aut Perne, Claudia verfasserin aut Strauß, Hans-Georg verfasserin aut Tecklenburg, Johanna verfasserin aut Holinski-Feder, Elke verfasserin aut Steinke-Lange, Verena verfasserin aut Mecklin, Jukka-Pekka verfasserin aut Plazzer, John-Paul verfasserin aut Pineda, Marta verfasserin aut Navarro, Matilde verfasserin aut Vida, Joan B. verfasserin aut Kariv, Revital verfasserin aut Rosner, Guy verfasserin aut Piñero, Tamara A. verfasserin aut Pavicic, Walter verfasserin aut Kalfayan, Pablo verfasserin aut Ten Broeke, Sanne W. verfasserin (DE-588)1185706615 (DE-627)1665059923 aut Jenkins, Mark A. verfasserin aut Sunde, Lone verfasserin aut Bernstein, Inge verfasserin aut Burn, John verfasserin aut Greenblatt, Marc verfasserin aut de Vos tot Nederveen Cappel, Wouter H. verfasserin aut Della Valle, Adriana verfasserin aut Lopez-Koestner, Francisco verfasserin aut Alvarez, Karin verfasserin aut Büttner, Reinhard verfasserin aut Görgens, Heike verfasserin aut Morak, Monika verfasserin aut Holzapfel, Stefanie verfasserin aut Hüneburg, Robert verfasserin aut Knebel Doeberitz, Magnus von verfasserin (DE-588)1022165291 (DE-627)71693289X (DE-576)364934239 aut Loeffler, Markus verfasserin aut Redler, Silke verfasserin aut Weitz, Jürgen verfasserin aut Pylvänäinen, Kirsi verfasserin aut Renkonen-Sinisalo, Laura verfasserin aut Lepistö, Anna verfasserin aut Hopper, John L. verfasserin aut Win, Aung K. verfasserin aut Lindor, Noralane M. verfasserin aut Gallinger, Steven verfasserin aut Le Marchand, Loïc verfasserin aut Newcomb, Polly A. verfasserin aut Figueiredo, Jane C. verfasserin aut Thibodeau, Stephen N. verfasserin aut Therkildsen, Christina verfasserin aut Wadt, Karin A. W. verfasserin aut Mourits, Marian J. E. verfasserin aut Ketabi, Zohreh verfasserin aut Denton, Oliver G. verfasserin aut Rødland, Einar A. verfasserin aut Vasen, Hans verfasserin aut Neffa, Florencia verfasserin aut Esperon, Patricia verfasserin aut Tjandra, Douglas verfasserin aut Möslein, Gabriela verfasserin aut Rokkones, Erik verfasserin aut Sampson, Julian R. verfasserin aut Evans, D. G. verfasserin aut Møller, Pål verfasserin aut Enthalten in European journal of cancer Amsterdam [u.a.] : Elsevier, 1992 148(2021), Seite 124-133 (DE-627)266883400 (DE-600)1468190-0 (DE-576)090954173 1879-0852 nnns volume:148 year:2021 pages:124-133 extent:10 https://doi.org/10.1016/j.ejca.2021.02.022 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0959804921001052 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 148 2021 124-133 10 2013 01 DE-16-250 3970785774 00 --%%-- --%%-- --%%-- --%%-- l01 23-08-21 2013 01 DE-16-250 00 s hd2021 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_87 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1435319745 Knebel Doeberitz, Magnus von 2013 01 DE-16-250 04 k (DE-627)1416741658 Pathologisches Institut 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_58 |
| allfields_unstemmed |
10.1016/j.ejca.2021.02.022 doi (DE-627)1767685572 (DE-599)KXP1767685572 (OCoLC)1341420921 DE-627 ger DE-627 rda eng Seppälä, Toni T. verfasserin (DE-588)1182620558 (DE-627)1662853734 aut Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants a Prospective Lynch Syndrome Database report Toni T. Seppälä, Mev Dominguez-Valentin, Emma J. Crosbie, Christoph Engel, Stefan Aretz, Finlay Macrae, Ingrid Winship, Gabriel Capella, Huw Thomas, Eivind Hovig, Maartje Nielsen, Rolf H. Sijmons, Lucio Bertario, Bernardo Bonanni, Maria G. Tibiletti, Giulia M. Cavestro, Miriam Mints, Nathan Gluck, Lior Katz, Karl Heinimann, Carlos A. Vaccaro, Kate Green, Fiona Lalloo, James Hill, Wolff Schmiegel, Deepak Vangala, Claudia Perne, Hans-Georg Strauß, Johanna Tecklenburg, Elke Holinski-Feder, Verena Steinke-Lange, Jukka-Pekka Mecklin, John-Paul Plazzer, Marta Pineda, Matilde Navarro, Joan B. Vida, Revital Kariv, Guy Rosner, Tamara A. Piñero, Walter Pavicic, Pablo Kalfayan, Sanne W. ten Broeke, Mark A. Jenkins, Lone Sunde, Inge Bernstein, John Burn, Marc Greenblatt, Wouter H. de Vos tot Nederveen Cappel, Adriana Della Valle, Francisco Lopez-Koestner, Karin Alvarez, Reinhard Büttner, Heike Görgens, Monika Morak, Stefanie Holzapfel, Robert Hüneburg, Magnus von Knebel Doeberitz, Markus Loeffler, Silke Redler, Jürgen Weitz, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, John L. Hopper, Aung K. Win, Noralane M. Lindor, Steven Gallinger, Loïc Le Marchand, Polly A. Newcomb, Jane C. Figueiredo, Stephen N. Thibodeau, Christina Therkildsen, Karin A.W. Wadt, Marian J.E. Mourits, Zohreh Ketabi, Oliver G. Denton, Einar A. Rødland, Hans Vasen, Florencia Neffa, Patricia Esperon, Douglas Tjandra, Gabriela Möslein, Erik Rokkones, Julian R. Sampson, D.G. Evans, Pål Møller 17 March 2021 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 23.08.2021 Purpose - This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. - Methods - The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. - Results - Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. - Conclusion - Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene- and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syndrome to improve outcomes. Endometrial cancer Hysterectomy Lynch syndrome Oophorectomy Ovarian cancer Risk-reducing surgery Dominguez-Valentin, Mev verfasserin aut Crosbie, Emma J. verfasserin aut Engel, Christoph verfasserin aut Aretz, Stefan verfasserin aut Macrae, Finlay verfasserin aut Winship, Ingrid verfasserin aut Capella, Gabriel verfasserin aut Thomas, Huw verfasserin aut Hovig, Eivind verfasserin aut Nielsen, Maartje verfasserin aut Sijmons, Rolf H. verfasserin aut Bertario, Lucio verfasserin aut Bonanni, Bernardo verfasserin aut Tibiletti, Maria G. verfasserin aut Cavestro, Giulia M. verfasserin aut Mints, Miriam verfasserin aut Gluck, Nathan verfasserin aut Katz, Lior verfasserin aut Heinimann, Karl verfasserin aut Vaccaro, Carlos A. verfasserin aut Green, Kate verfasserin aut Lalloo, Fiona verfasserin aut Hill, James verfasserin aut Schmiegel, Wolff verfasserin aut Vangala, Deepak verfasserin aut Perne, Claudia verfasserin aut Strauß, Hans-Georg verfasserin aut Tecklenburg, Johanna verfasserin aut Holinski-Feder, Elke verfasserin aut Steinke-Lange, Verena verfasserin aut Mecklin, Jukka-Pekka verfasserin aut Plazzer, John-Paul verfasserin aut Pineda, Marta verfasserin aut Navarro, Matilde verfasserin aut Vida, Joan B. verfasserin aut Kariv, Revital verfasserin aut Rosner, Guy verfasserin aut Piñero, Tamara A. verfasserin aut Pavicic, Walter verfasserin aut Kalfayan, Pablo verfasserin aut Ten Broeke, Sanne W. verfasserin (DE-588)1185706615 (DE-627)1665059923 aut Jenkins, Mark A. verfasserin aut Sunde, Lone verfasserin aut Bernstein, Inge verfasserin aut Burn, John verfasserin aut Greenblatt, Marc verfasserin aut de Vos tot Nederveen Cappel, Wouter H. verfasserin aut Della Valle, Adriana verfasserin aut Lopez-Koestner, Francisco verfasserin aut Alvarez, Karin verfasserin aut Büttner, Reinhard verfasserin aut Görgens, Heike verfasserin aut Morak, Monika verfasserin aut Holzapfel, Stefanie verfasserin aut Hüneburg, Robert verfasserin aut Knebel Doeberitz, Magnus von verfasserin (DE-588)1022165291 (DE-627)71693289X (DE-576)364934239 aut Loeffler, Markus verfasserin aut Redler, Silke verfasserin aut Weitz, Jürgen verfasserin aut Pylvänäinen, Kirsi verfasserin aut Renkonen-Sinisalo, Laura verfasserin aut Lepistö, Anna verfasserin aut Hopper, John L. verfasserin aut Win, Aung K. verfasserin aut Lindor, Noralane M. verfasserin aut Gallinger, Steven verfasserin aut Le Marchand, Loïc verfasserin aut Newcomb, Polly A. verfasserin aut Figueiredo, Jane C. verfasserin aut Thibodeau, Stephen N. verfasserin aut Therkildsen, Christina verfasserin aut Wadt, Karin A. W. verfasserin aut Mourits, Marian J. E. verfasserin aut Ketabi, Zohreh verfasserin aut Denton, Oliver G. verfasserin aut Rødland, Einar A. verfasserin aut Vasen, Hans verfasserin aut Neffa, Florencia verfasserin aut Esperon, Patricia verfasserin aut Tjandra, Douglas verfasserin aut Möslein, Gabriela verfasserin aut Rokkones, Erik verfasserin aut Sampson, Julian R. verfasserin aut Evans, D. G. verfasserin aut Møller, Pål verfasserin aut Enthalten in European journal of cancer Amsterdam [u.a.] : Elsevier, 1992 148(2021), Seite 124-133 (DE-627)266883400 (DE-600)1468190-0 (DE-576)090954173 1879-0852 nnns volume:148 year:2021 pages:124-133 extent:10 https://doi.org/10.1016/j.ejca.2021.02.022 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0959804921001052 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 148 2021 124-133 10 2013 01 DE-16-250 3970785774 00 --%%-- --%%-- --%%-- --%%-- l01 23-08-21 2013 01 DE-16-250 00 s hd2021 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_87 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1435319745 Knebel Doeberitz, Magnus von 2013 01 DE-16-250 04 k (DE-627)1416741658 Pathologisches Institut 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_58 |
| allfieldsGer |
10.1016/j.ejca.2021.02.022 doi (DE-627)1767685572 (DE-599)KXP1767685572 (OCoLC)1341420921 DE-627 ger DE-627 rda eng Seppälä, Toni T. verfasserin (DE-588)1182620558 (DE-627)1662853734 aut Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants a Prospective Lynch Syndrome Database report Toni T. Seppälä, Mev Dominguez-Valentin, Emma J. Crosbie, Christoph Engel, Stefan Aretz, Finlay Macrae, Ingrid Winship, Gabriel Capella, Huw Thomas, Eivind Hovig, Maartje Nielsen, Rolf H. Sijmons, Lucio Bertario, Bernardo Bonanni, Maria G. Tibiletti, Giulia M. Cavestro, Miriam Mints, Nathan Gluck, Lior Katz, Karl Heinimann, Carlos A. Vaccaro, Kate Green, Fiona Lalloo, James Hill, Wolff Schmiegel, Deepak Vangala, Claudia Perne, Hans-Georg Strauß, Johanna Tecklenburg, Elke Holinski-Feder, Verena Steinke-Lange, Jukka-Pekka Mecklin, John-Paul Plazzer, Marta Pineda, Matilde Navarro, Joan B. Vida, Revital Kariv, Guy Rosner, Tamara A. Piñero, Walter Pavicic, Pablo Kalfayan, Sanne W. ten Broeke, Mark A. Jenkins, Lone Sunde, Inge Bernstein, John Burn, Marc Greenblatt, Wouter H. de Vos tot Nederveen Cappel, Adriana Della Valle, Francisco Lopez-Koestner, Karin Alvarez, Reinhard Büttner, Heike Görgens, Monika Morak, Stefanie Holzapfel, Robert Hüneburg, Magnus von Knebel Doeberitz, Markus Loeffler, Silke Redler, Jürgen Weitz, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, John L. Hopper, Aung K. Win, Noralane M. Lindor, Steven Gallinger, Loïc Le Marchand, Polly A. Newcomb, Jane C. Figueiredo, Stephen N. Thibodeau, Christina Therkildsen, Karin A.W. Wadt, Marian J.E. Mourits, Zohreh Ketabi, Oliver G. Denton, Einar A. Rødland, Hans Vasen, Florencia Neffa, Patricia Esperon, Douglas Tjandra, Gabriela Möslein, Erik Rokkones, Julian R. Sampson, D.G. Evans, Pål Møller 17 March 2021 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 23.08.2021 Purpose - This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. - Methods - The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. - Results - Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. - Conclusion - Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene- and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syndrome to improve outcomes. Endometrial cancer Hysterectomy Lynch syndrome Oophorectomy Ovarian cancer Risk-reducing surgery Dominguez-Valentin, Mev verfasserin aut Crosbie, Emma J. verfasserin aut Engel, Christoph verfasserin aut Aretz, Stefan verfasserin aut Macrae, Finlay verfasserin aut Winship, Ingrid verfasserin aut Capella, Gabriel verfasserin aut Thomas, Huw verfasserin aut Hovig, Eivind verfasserin aut Nielsen, Maartje verfasserin aut Sijmons, Rolf H. verfasserin aut Bertario, Lucio verfasserin aut Bonanni, Bernardo verfasserin aut Tibiletti, Maria G. verfasserin aut Cavestro, Giulia M. verfasserin aut Mints, Miriam verfasserin aut Gluck, Nathan verfasserin aut Katz, Lior verfasserin aut Heinimann, Karl verfasserin aut Vaccaro, Carlos A. verfasserin aut Green, Kate verfasserin aut Lalloo, Fiona verfasserin aut Hill, James verfasserin aut Schmiegel, Wolff verfasserin aut Vangala, Deepak verfasserin aut Perne, Claudia verfasserin aut Strauß, Hans-Georg verfasserin aut Tecklenburg, Johanna verfasserin aut Holinski-Feder, Elke verfasserin aut Steinke-Lange, Verena verfasserin aut Mecklin, Jukka-Pekka verfasserin aut Plazzer, John-Paul verfasserin aut Pineda, Marta verfasserin aut Navarro, Matilde verfasserin aut Vida, Joan B. verfasserin aut Kariv, Revital verfasserin aut Rosner, Guy verfasserin aut Piñero, Tamara A. verfasserin aut Pavicic, Walter verfasserin aut Kalfayan, Pablo verfasserin aut Ten Broeke, Sanne W. verfasserin (DE-588)1185706615 (DE-627)1665059923 aut Jenkins, Mark A. verfasserin aut Sunde, Lone verfasserin aut Bernstein, Inge verfasserin aut Burn, John verfasserin aut Greenblatt, Marc verfasserin aut de Vos tot Nederveen Cappel, Wouter H. verfasserin aut Della Valle, Adriana verfasserin aut Lopez-Koestner, Francisco verfasserin aut Alvarez, Karin verfasserin aut Büttner, Reinhard verfasserin aut Görgens, Heike verfasserin aut Morak, Monika verfasserin aut Holzapfel, Stefanie verfasserin aut Hüneburg, Robert verfasserin aut Knebel Doeberitz, Magnus von verfasserin (DE-588)1022165291 (DE-627)71693289X (DE-576)364934239 aut Loeffler, Markus verfasserin aut Redler, Silke verfasserin aut Weitz, Jürgen verfasserin aut Pylvänäinen, Kirsi verfasserin aut Renkonen-Sinisalo, Laura verfasserin aut Lepistö, Anna verfasserin aut Hopper, John L. verfasserin aut Win, Aung K. verfasserin aut Lindor, Noralane M. verfasserin aut Gallinger, Steven verfasserin aut Le Marchand, Loïc verfasserin aut Newcomb, Polly A. verfasserin aut Figueiredo, Jane C. verfasserin aut Thibodeau, Stephen N. verfasserin aut Therkildsen, Christina verfasserin aut Wadt, Karin A. W. verfasserin aut Mourits, Marian J. E. verfasserin aut Ketabi, Zohreh verfasserin aut Denton, Oliver G. verfasserin aut Rødland, Einar A. verfasserin aut Vasen, Hans verfasserin aut Neffa, Florencia verfasserin aut Esperon, Patricia verfasserin aut Tjandra, Douglas verfasserin aut Möslein, Gabriela verfasserin aut Rokkones, Erik verfasserin aut Sampson, Julian R. verfasserin aut Evans, D. G. verfasserin aut Møller, Pål verfasserin aut Enthalten in European journal of cancer Amsterdam [u.a.] : Elsevier, 1992 148(2021), Seite 124-133 (DE-627)266883400 (DE-600)1468190-0 (DE-576)090954173 1879-0852 nnns volume:148 year:2021 pages:124-133 extent:10 https://doi.org/10.1016/j.ejca.2021.02.022 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0959804921001052 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 148 2021 124-133 10 2013 01 DE-16-250 3970785774 00 --%%-- --%%-- --%%-- --%%-- l01 23-08-21 2013 01 DE-16-250 00 s hd2021 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_87 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1435319745 Knebel Doeberitz, Magnus von 2013 01 DE-16-250 04 k (DE-627)1416741658 Pathologisches Institut 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_58 |
| allfieldsSound |
10.1016/j.ejca.2021.02.022 doi (DE-627)1767685572 (DE-599)KXP1767685572 (OCoLC)1341420921 DE-627 ger DE-627 rda eng Seppälä, Toni T. verfasserin (DE-588)1182620558 (DE-627)1662853734 aut Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants a Prospective Lynch Syndrome Database report Toni T. Seppälä, Mev Dominguez-Valentin, Emma J. Crosbie, Christoph Engel, Stefan Aretz, Finlay Macrae, Ingrid Winship, Gabriel Capella, Huw Thomas, Eivind Hovig, Maartje Nielsen, Rolf H. Sijmons, Lucio Bertario, Bernardo Bonanni, Maria G. Tibiletti, Giulia M. Cavestro, Miriam Mints, Nathan Gluck, Lior Katz, Karl Heinimann, Carlos A. Vaccaro, Kate Green, Fiona Lalloo, James Hill, Wolff Schmiegel, Deepak Vangala, Claudia Perne, Hans-Georg Strauß, Johanna Tecklenburg, Elke Holinski-Feder, Verena Steinke-Lange, Jukka-Pekka Mecklin, John-Paul Plazzer, Marta Pineda, Matilde Navarro, Joan B. Vida, Revital Kariv, Guy Rosner, Tamara A. Piñero, Walter Pavicic, Pablo Kalfayan, Sanne W. ten Broeke, Mark A. Jenkins, Lone Sunde, Inge Bernstein, John Burn, Marc Greenblatt, Wouter H. de Vos tot Nederveen Cappel, Adriana Della Valle, Francisco Lopez-Koestner, Karin Alvarez, Reinhard Büttner, Heike Görgens, Monika Morak, Stefanie Holzapfel, Robert Hüneburg, Magnus von Knebel Doeberitz, Markus Loeffler, Silke Redler, Jürgen Weitz, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, John L. Hopper, Aung K. Win, Noralane M. Lindor, Steven Gallinger, Loïc Le Marchand, Polly A. Newcomb, Jane C. Figueiredo, Stephen N. Thibodeau, Christina Therkildsen, Karin A.W. Wadt, Marian J.E. Mourits, Zohreh Ketabi, Oliver G. Denton, Einar A. Rødland, Hans Vasen, Florencia Neffa, Patricia Esperon, Douglas Tjandra, Gabriela Möslein, Erik Rokkones, Julian R. Sampson, D.G. Evans, Pål Møller 17 March 2021 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 23.08.2021 Purpose - This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. - Methods - The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. - Results - Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. - Conclusion - Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene- and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syndrome to improve outcomes. Endometrial cancer Hysterectomy Lynch syndrome Oophorectomy Ovarian cancer Risk-reducing surgery Dominguez-Valentin, Mev verfasserin aut Crosbie, Emma J. verfasserin aut Engel, Christoph verfasserin aut Aretz, Stefan verfasserin aut Macrae, Finlay verfasserin aut Winship, Ingrid verfasserin aut Capella, Gabriel verfasserin aut Thomas, Huw verfasserin aut Hovig, Eivind verfasserin aut Nielsen, Maartje verfasserin aut Sijmons, Rolf H. verfasserin aut Bertario, Lucio verfasserin aut Bonanni, Bernardo verfasserin aut Tibiletti, Maria G. verfasserin aut Cavestro, Giulia M. verfasserin aut Mints, Miriam verfasserin aut Gluck, Nathan verfasserin aut Katz, Lior verfasserin aut Heinimann, Karl verfasserin aut Vaccaro, Carlos A. verfasserin aut Green, Kate verfasserin aut Lalloo, Fiona verfasserin aut Hill, James verfasserin aut Schmiegel, Wolff verfasserin aut Vangala, Deepak verfasserin aut Perne, Claudia verfasserin aut Strauß, Hans-Georg verfasserin aut Tecklenburg, Johanna verfasserin aut Holinski-Feder, Elke verfasserin aut Steinke-Lange, Verena verfasserin aut Mecklin, Jukka-Pekka verfasserin aut Plazzer, John-Paul verfasserin aut Pineda, Marta verfasserin aut Navarro, Matilde verfasserin aut Vida, Joan B. verfasserin aut Kariv, Revital verfasserin aut Rosner, Guy verfasserin aut Piñero, Tamara A. verfasserin aut Pavicic, Walter verfasserin aut Kalfayan, Pablo verfasserin aut Ten Broeke, Sanne W. verfasserin (DE-588)1185706615 (DE-627)1665059923 aut Jenkins, Mark A. verfasserin aut Sunde, Lone verfasserin aut Bernstein, Inge verfasserin aut Burn, John verfasserin aut Greenblatt, Marc verfasserin aut de Vos tot Nederveen Cappel, Wouter H. verfasserin aut Della Valle, Adriana verfasserin aut Lopez-Koestner, Francisco verfasserin aut Alvarez, Karin verfasserin aut Büttner, Reinhard verfasserin aut Görgens, Heike verfasserin aut Morak, Monika verfasserin aut Holzapfel, Stefanie verfasserin aut Hüneburg, Robert verfasserin aut Knebel Doeberitz, Magnus von verfasserin (DE-588)1022165291 (DE-627)71693289X (DE-576)364934239 aut Loeffler, Markus verfasserin aut Redler, Silke verfasserin aut Weitz, Jürgen verfasserin aut Pylvänäinen, Kirsi verfasserin aut Renkonen-Sinisalo, Laura verfasserin aut Lepistö, Anna verfasserin aut Hopper, John L. verfasserin aut Win, Aung K. verfasserin aut Lindor, Noralane M. verfasserin aut Gallinger, Steven verfasserin aut Le Marchand, Loïc verfasserin aut Newcomb, Polly A. verfasserin aut Figueiredo, Jane C. verfasserin aut Thibodeau, Stephen N. verfasserin aut Therkildsen, Christina verfasserin aut Wadt, Karin A. W. verfasserin aut Mourits, Marian J. E. verfasserin aut Ketabi, Zohreh verfasserin aut Denton, Oliver G. verfasserin aut Rødland, Einar A. verfasserin aut Vasen, Hans verfasserin aut Neffa, Florencia verfasserin aut Esperon, Patricia verfasserin aut Tjandra, Douglas verfasserin aut Möslein, Gabriela verfasserin aut Rokkones, Erik verfasserin aut Sampson, Julian R. verfasserin aut Evans, D. G. verfasserin aut Møller, Pål verfasserin aut Enthalten in European journal of cancer Amsterdam [u.a.] : Elsevier, 1992 148(2021), Seite 124-133 (DE-627)266883400 (DE-600)1468190-0 (DE-576)090954173 1879-0852 nnns volume:148 year:2021 pages:124-133 extent:10 https://doi.org/10.1016/j.ejca.2021.02.022 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0959804921001052 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 148 2021 124-133 10 2013 01 DE-16-250 3970785774 00 --%%-- --%%-- --%%-- --%%-- l01 23-08-21 2013 01 DE-16-250 00 s hd2021 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_87 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1435319745 Knebel Doeberitz, Magnus von 2013 01 DE-16-250 04 k (DE-627)1416741658 Pathologisches Institut 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_58 |
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Seppälä, Toni T. @@aut@@ Dominguez-Valentin, Mev @@aut@@ Crosbie, Emma J. @@aut@@ Engel, Christoph @@aut@@ Aretz, Stefan @@aut@@ Macrae, Finlay @@aut@@ Winship, Ingrid @@aut@@ Capella, Gabriel @@aut@@ Thomas, Huw @@aut@@ Hovig, Eivind @@aut@@ Nielsen, Maartje @@aut@@ Sijmons, Rolf H. @@aut@@ Bertario, Lucio @@aut@@ Bonanni, Bernardo @@aut@@ Tibiletti, Maria G. @@aut@@ Cavestro, Giulia M. @@aut@@ Mints, Miriam @@aut@@ Gluck, Nathan @@aut@@ Katz, Lior @@aut@@ Heinimann, Karl @@aut@@ Vaccaro, Carlos A. @@aut@@ Green, Kate @@aut@@ Lalloo, Fiona @@aut@@ Hill, James @@aut@@ Schmiegel, Wolff @@aut@@ Vangala, Deepak @@aut@@ Perne, Claudia @@aut@@ Strauß, Hans-Georg @@aut@@ Tecklenburg, Johanna @@aut@@ Holinski-Feder, Elke @@aut@@ Steinke-Lange, Verena @@aut@@ Mecklin, Jukka-Pekka @@aut@@ Plazzer, John-Paul @@aut@@ Pineda, Marta @@aut@@ Navarro, Matilde @@aut@@ Vida, Joan B. @@aut@@ Kariv, Revital @@aut@@ Rosner, Guy @@aut@@ Piñero, Tamara A. @@aut@@ Pavicic, Walter @@aut@@ Kalfayan, Pablo @@aut@@ Ten Broeke, Sanne W. @@aut@@ Jenkins, Mark A. @@aut@@ Sunde, Lone @@aut@@ Bernstein, Inge @@aut@@ Burn, John @@aut@@ Greenblatt, Marc @@aut@@ de Vos tot Nederveen Cappel, Wouter H. @@aut@@ Della Valle, Adriana @@aut@@ Lopez-Koestner, Francisco @@aut@@ Alvarez, Karin @@aut@@ Büttner, Reinhard @@aut@@ Görgens, Heike @@aut@@ Morak, Monika @@aut@@ Holzapfel, Stefanie @@aut@@ Hüneburg, Robert @@aut@@ Knebel Doeberitz, Magnus von @@aut@@ Loeffler, Markus @@aut@@ Redler, Silke @@aut@@ Weitz, Jürgen @@aut@@ Pylvänäinen, Kirsi @@aut@@ Renkonen-Sinisalo, Laura @@aut@@ Lepistö, Anna @@aut@@ Hopper, John L. @@aut@@ Win, Aung K. @@aut@@ Lindor, Noralane M. @@aut@@ Gallinger, Steven @@aut@@ Le Marchand, Loïc @@aut@@ Newcomb, Polly A. @@aut@@ Figueiredo, Jane C. @@aut@@ Thibodeau, Stephen N. @@aut@@ Therkildsen, Christina @@aut@@ Wadt, Karin A. W. @@aut@@ Mourits, Marian J. E. @@aut@@ Ketabi, Zohreh @@aut@@ Denton, Oliver G. @@aut@@ Rødland, Einar A. @@aut@@ Vasen, Hans @@aut@@ Neffa, Florencia @@aut@@ Esperon, Patricia @@aut@@ Tjandra, Douglas @@aut@@ Möslein, Gabriela @@aut@@ Rokkones, Erik @@aut@@ Sampson, Julian R. @@aut@@ Evans, D. G. @@aut@@ Møller, Pål @@aut@@ |
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Seppälä, Mev Dominguez-Valentin, Emma J. Crosbie, Christoph Engel, Stefan Aretz, Finlay Macrae, Ingrid Winship, Gabriel Capella, Huw Thomas, Eivind Hovig, Maartje Nielsen, Rolf H. Sijmons, Lucio Bertario, Bernardo Bonanni, Maria G. Tibiletti, Giulia M. Cavestro, Miriam Mints, Nathan Gluck, Lior Katz, Karl Heinimann, Carlos A. Vaccaro, Kate Green, Fiona Lalloo, James Hill, Wolff Schmiegel, Deepak Vangala, Claudia Perne, Hans-Georg Strauß, Johanna Tecklenburg, Elke Holinski-Feder, Verena Steinke-Lange, Jukka-Pekka Mecklin, John-Paul Plazzer, Marta Pineda, Matilde Navarro, Joan B. Vida, Revital Kariv, Guy Rosner, Tamara A. Piñero, Walter Pavicic, Pablo Kalfayan, Sanne W. ten Broeke, Mark A. Jenkins, Lone Sunde, Inge Bernstein, John Burn, Marc Greenblatt, Wouter H. de Vos tot Nederveen Cappel, Adriana Della Valle, Francisco Lopez-Koestner, Karin Alvarez, Reinhard Büttner, Heike Görgens, Monika Morak, Stefanie Holzapfel, Robert Hüneburg, Magnus von Knebel Doeberitz, Markus Loeffler, Silke Redler, Jürgen Weitz, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, John L. Hopper, Aung K. Win, Noralane M. Lindor, Steven Gallinger, Loïc Le Marchand, Polly A. Newcomb, Jane C. Figueiredo, Stephen N. Thibodeau, Christina Therkildsen, Karin A.W. Wadt, Marian J.E. Mourits, Zohreh Ketabi, Oliver G. Denton, Einar A. Rødland, Hans Vasen, Florencia Neffa, Patricia Esperon, Douglas Tjandra, Gabriela Möslein, Erik Rokkones, Julian R. Sampson, D.G. Evans, Pål Møller</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">17 March 2021</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">10</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Gesehen am 23.08.2021</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose - This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. - Methods - The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. - Results - Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. - Conclusion - Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene- and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syndrome to improve outcomes.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Endometrial cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hysterectomy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lynch syndrome</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oophorectomy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ovarian cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Risk-reducing surgery</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dominguez-Valentin, Mev</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" 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Seppälä, Toni T. |
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Seppälä, Toni T. misc Endometrial cancer misc Hysterectomy misc Lynch syndrome misc Oophorectomy misc Ovarian cancer misc Risk-reducing surgery 2013 hd2021 2013 wissenschaftlicher Artikel (Zeitschrift) 2013 per_87 2013 s_10 2013 Knebel Doeberitz, Magnus von 2013 Pathologisches Institut 2013 Verfasser 2013 pos_58 Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants a Prospective Lynch Syndrome Database report |
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Seppälä, Toni T. |
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Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants a Prospective Lynch Syndrome Database report Toni T. Seppälä, Mev Dominguez-Valentin, Emma J. Crosbie, Christoph Engel, Stefan Aretz, Finlay Macrae, Ingrid Winship, Gabriel Capella, Huw Thomas, Eivind Hovig, Maartje Nielsen, Rolf H. Sijmons, Lucio Bertario, Bernardo Bonanni, Maria G. Tibiletti, Giulia M. Cavestro, Miriam Mints, Nathan Gluck, Lior Katz, Karl Heinimann, Carlos A. Vaccaro, Kate Green, Fiona Lalloo, James Hill, Wolff Schmiegel, Deepak Vangala, Claudia Perne, Hans-Georg Strauß, Johanna Tecklenburg, Elke Holinski-Feder, Verena Steinke-Lange, Jukka-Pekka Mecklin, John-Paul Plazzer, Marta Pineda, Matilde Navarro, Joan B. Vida, Revital Kariv, Guy Rosner, Tamara A. Piñero, Walter Pavicic, Pablo Kalfayan, Sanne W. ten Broeke, Mark A. Jenkins, Lone Sunde, Inge Bernstein, John Burn, Marc Greenblatt, Wouter H. de Vos tot Nederveen Cappel, Adriana Della Valle, Francisco Lopez-Koestner, Karin Alvarez, Reinhard Büttner, Heike Görgens, Monika Morak, Stefanie Holzapfel, Robert Hüneburg, Magnus von Knebel Doeberitz, Markus Loeffler, Silke Redler, Jürgen Weitz, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, John L. Hopper, Aung K. Win, Noralane M. Lindor, Steven Gallinger, Loïc Le Marchand, Polly A. Newcomb, Jane C. Figueiredo, Stephen N. Thibodeau, Christina Therkildsen, Karin A.W. Wadt, Marian J.E. Mourits, Zohreh Ketabi, Oliver G. Denton, Einar A. Rødland, Hans Vasen, Florencia Neffa, Patricia Esperon, Douglas Tjandra, Gabriela Möslein, Erik Rokkones, Julian R. Sampson, D.G. Evans, Pål Møller |
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Seppälä, Toni T. Dominguez-Valentin, Mev Crosbie, Emma J. Engel, Christoph Aretz, Stefan Macrae, Finlay Winship, Ingrid Capella, Gabriel Thomas, Huw Hovig, Eivind Nielsen, Maartje Sijmons, Rolf H. Bertario, Lucio Bonanni, Bernardo Tibiletti, Maria G. Cavestro, Giulia M. Mints, Miriam Gluck, Nathan Katz, Lior Heinimann, Karl Vaccaro, Carlos A. Green, Kate Lalloo, Fiona Hill, James Schmiegel, Wolff Vangala, Deepak Perne, Claudia Strauß, Hans-Georg Tecklenburg, Johanna Holinski-Feder, Elke Steinke-Lange, Verena Mecklin, Jukka-Pekka Plazzer, John-Paul Pineda, Marta Navarro, Matilde Vida, Joan B. Kariv, Revital Rosner, Guy Piñero, Tamara A. Pavicic, Walter Kalfayan, Pablo Ten Broeke, Sanne W. Jenkins, Mark A. Sunde, Lone Bernstein, Inge Burn, John Greenblatt, Marc de Vos tot Nederveen Cappel, Wouter H. Della Valle, Adriana Lopez-Koestner, Francisco Alvarez, Karin Büttner, Reinhard Görgens, Heike Morak, Monika Holzapfel, Stefanie Hüneburg, Robert Knebel Doeberitz, Magnus von Loeffler, Markus Redler, Silke Weitz, Jürgen Pylvänäinen, Kirsi Renkonen-Sinisalo, Laura Lepistö, Anna Hopper, John L. Win, Aung K. Lindor, Noralane M. Gallinger, Steven Le Marchand, Loïc Newcomb, Polly A. Figueiredo, Jane C. Thibodeau, Stephen N. Therkildsen, Christina Wadt, Karin A. W. Mourits, Marian J. E. Ketabi, Zohreh Denton, Oliver G. Rødland, Einar A. Vasen, Hans Neffa, Florencia Esperon, Patricia Tjandra, Douglas Möslein, Gabriela Rokkones, Erik Sampson, Julian R. Evans, D. G. Møller, Pål |
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uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variantsa prospective lynch syndrome database report |
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Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants a Prospective Lynch Syndrome Database report |
| abstract |
Purpose - This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. - Methods - The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. - Results - Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. - Conclusion - Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene- and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syndrome to improve outcomes. Gesehen am 23.08.2021 |
| abstractGer |
Purpose - This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. - Methods - The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. - Results - Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. - Conclusion - Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene- and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syndrome to improve outcomes. Gesehen am 23.08.2021 |
| abstract_unstemmed |
Purpose - This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. - Methods - The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. - Results - Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. - Conclusion - Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene- and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syndrome to improve outcomes. Gesehen am 23.08.2021 |
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Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants |
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Seppälä, Mev Dominguez-Valentin, Emma J. Crosbie, Christoph Engel, Stefan Aretz, Finlay Macrae, Ingrid Winship, Gabriel Capella, Huw Thomas, Eivind Hovig, Maartje Nielsen, Rolf H. Sijmons, Lucio Bertario, Bernardo Bonanni, Maria G. Tibiletti, Giulia M. Cavestro, Miriam Mints, Nathan Gluck, Lior Katz, Karl Heinimann, Carlos A. Vaccaro, Kate Green, Fiona Lalloo, James Hill, Wolff Schmiegel, Deepak Vangala, Claudia Perne, Hans-Georg Strauß, Johanna Tecklenburg, Elke Holinski-Feder, Verena Steinke-Lange, Jukka-Pekka Mecklin, John-Paul Plazzer, Marta Pineda, Matilde Navarro, Joan B. Vida, Revital Kariv, Guy Rosner, Tamara A. Piñero, Walter Pavicic, Pablo Kalfayan, Sanne W. ten Broeke, Mark A. Jenkins, Lone Sunde, Inge Bernstein, John Burn, Marc Greenblatt, Wouter H. de Vos tot Nederveen Cappel, Adriana Della Valle, Francisco Lopez-Koestner, Karin Alvarez, Reinhard Büttner, Heike Görgens, Monika Morak, Stefanie Holzapfel, Robert Hüneburg, Magnus von Knebel Doeberitz, Markus Loeffler, Silke Redler, Jürgen Weitz, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, John L. Hopper, Aung K. Win, Noralane M. Lindor, Steven Gallinger, Loïc Le Marchand, Polly A. Newcomb, Jane C. Figueiredo, Stephen N. Thibodeau, Christina Therkildsen, Karin A.W. Wadt, Marian J.E. Mourits, Zohreh Ketabi, Oliver G. Denton, Einar A. Rødland, Hans Vasen, Florencia Neffa, Patricia Esperon, Douglas Tjandra, Gabriela Möslein, Erik Rokkones, Julian R. Sampson, D.G. Evans, Pål Møller</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">17 March 2021</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">10</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Gesehen am 23.08.2021</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose - This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. - Methods - The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. - Results - Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. - Conclusion - Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene- and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syndrome to improve outcomes.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Endometrial cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hysterectomy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lynch syndrome</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oophorectomy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ovarian cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Risk-reducing surgery</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dominguez-Valentin, Mev</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" 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