Genome-wide analyses of smoking behaviors in schizophrenia : findings from the Psychiatric Genomics Consortium
While 17% of US adults use tobacco regularly, smoking rates among persons with schizophrenia are upwards of 60%. Research supports a shared etiological basis for smoking and schizophrenia, including findings from genome-wide association studies (GWAS). However, few studies have directly tested wheth...
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| Autor*in: |
Peterson, Roseann E. [verfasserIn] Bigdeli, Tim B. [verfasserIn] Ripke, Stephan [verfasserIn] Bacanu, Silviu-Alin [verfasserIn] Gejman, Pablo V. [verfasserIn] Levinson, Douglas F. [verfasserIn] Li, Qingqin S. [verfasserIn] Rujescu, Dan [verfasserIn] Rietschel, Marcella - 1957- [verfasserIn] Weinberger, Daniel R. [verfasserIn] Straub, Richard E. [verfasserIn] Walters, James T. R. [verfasserIn] Owen, Michael J. [verfasserIn] O'Donovan, Michael C. [verfasserIn] Mowry, Bryan J. [verfasserIn] Ophoff, Roel A. [verfasserIn] Andreassen, Ole A. [verfasserIn] Esko, Tõnu [verfasserIn] Petryshen, Tracey L. [verfasserIn] Kendler, Kenneth S. [verfasserIn] Fanous, Ayman H. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
May 2021 |
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| Rechteinformationen: |
Urheberrechtsschutz 1.0 |
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| Schlagwörter: |
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| Anmerkung: |
Gesehen am 22.09.2021 |
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| Umfang: |
10 |
| Übergeordnetes Werk: |
Enthalten in: Journal of psychiatric research - Amsterdam [u.a.] : Elsevier Science, 1961, 137(2021) vom: Mai, Seite 215-224 |
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| Übergeordnetes Werk: |
volume:137 ; year:2021 ; month:05 ; pages:215-224 ; extent:10 |
| Links: |
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| DOI / URN: |
10.1016/j.jpsychires.2021.02.027 |
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| 245 | 1 | 0 | |a Genome-wide analyses of smoking behaviors in schizophrenia |b findings from the Psychiatric Genomics Consortium |c Roseann E. Peterson, Tim B. Bigdeli, Stephan Ripke, Silviu-Alin Bacanu, Pablo V. Gejman, Douglas F. Levinson, Qingqin S. Li, Dan Rujescu, Marcella Rietschel, Daniel R. Weinberger, Richard E. Straub, James T.R. Walters, Michael J. Owen, Michael C. O'Donovan, Bryan J. Mowry, Roel A. Ophoff, Ole A. Andreassen, Tõnu Esko, Tracey L. Petryshen, Kenneth S. Kendler, Ayman H. Fanous |
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| 520 | |a While 17% of US adults use tobacco regularly, smoking rates among persons with schizophrenia are upwards of 60%. Research supports a shared etiological basis for smoking and schizophrenia, including findings from genome-wide association studies (GWAS). However, few studies have directly tested whether the same or distinct genetic variants also influence smoking behavior among schizophrenia cases. Using data from the Psychiatric Genomics Consortium (PGC) study of schizophrenia (35476 cases, 46839 controls), we estimated genetic correlations between these traits and tested whether polygenic risk scores (PRS) constructed from the results of smoking behaviors GWAS were associated with schizophrenia risk or smoking behaviors among schizophrenia cases. Results indicated significant genetic correlations of schizophrenia with smoking initiation (rg=0.159; P=5.05×10−10), cigarettes-smoked-per-day (rg=0.094; P=0.006), and age-of-onset of smoking (rg=0.10; P=0.009). Comparing smoking behaviors among schizophrenia cases to the general population, we observe positive genetic correlations for smoking initiation (rg=0.624, P=0.002) and cigarettes-smoked-per-day (rg=0.689, P=0.120). Similarly, TAG-based PRS for smoking initiation and cigarettes-smoked-per-day were significantly associated with smoking initiation (P=3.49×10−5) and cigarettes-smoked-per-day (P=0.007) among schizophrenia cases. We performed the first GWAS of smoking behavior among schizophrenia cases and identified a novel association with cigarettes-smoked-per-day upstream of the TMEM106B gene on chromosome 7p21.3 (rs148253479, P=3.18×10−8, n=3520). Results provide evidence of a partially shared genetic basis for schizophrenia and smoking behaviors. Additionally, genetic risk factors for smoking behaviors were largely shared across schizophrenia and non-schizophrenia populations. Future research should address mechanisms underlying these associations to aid both schizophrenia and smoking treatment and prevention efforts. | ||
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10.1016/j.jpsychires.2021.02.027 doi (DE-627)177163846X (DE-599)KXP177163846X (OCoLC)1341421388 DE-627 ger DE-627 rda eng Peterson, Roseann E. verfasserin (DE-588)1199364185 (DE-627)1681643510 aut Genome-wide analyses of smoking behaviors in schizophrenia findings from the Psychiatric Genomics Consortium Roseann E. Peterson, Tim B. Bigdeli, Stephan Ripke, Silviu-Alin Bacanu, Pablo V. Gejman, Douglas F. Levinson, Qingqin S. Li, Dan Rujescu, Marcella Rietschel, Daniel R. Weinberger, Richard E. Straub, James T.R. Walters, Michael J. Owen, Michael C. O'Donovan, Bryan J. Mowry, Roel A. Ophoff, Ole A. Andreassen, Tõnu Esko, Tracey L. Petryshen, Kenneth S. Kendler, Ayman H. Fanous May 2021 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 22.09.2021 While 17% of US adults use tobacco regularly, smoking rates among persons with schizophrenia are upwards of 60%. Research supports a shared etiological basis for smoking and schizophrenia, including findings from genome-wide association studies (GWAS). However, few studies have directly tested whether the same or distinct genetic variants also influence smoking behavior among schizophrenia cases. Using data from the Psychiatric Genomics Consortium (PGC) study of schizophrenia (35476 cases, 46839 controls), we estimated genetic correlations between these traits and tested whether polygenic risk scores (PRS) constructed from the results of smoking behaviors GWAS were associated with schizophrenia risk or smoking behaviors among schizophrenia cases. Results indicated significant genetic correlations of schizophrenia with smoking initiation (rg=0.159; P=5.05×10−10), cigarettes-smoked-per-day (rg=0.094; P=0.006), and age-of-onset of smoking (rg=0.10; P=0.009). Comparing smoking behaviors among schizophrenia cases to the general population, we observe positive genetic correlations for smoking initiation (rg=0.624, P=0.002) and cigarettes-smoked-per-day (rg=0.689, P=0.120). Similarly, TAG-based PRS for smoking initiation and cigarettes-smoked-per-day were significantly associated with smoking initiation (P=3.49×10−5) and cigarettes-smoked-per-day (P=0.007) among schizophrenia cases. We performed the first GWAS of smoking behavior among schizophrenia cases and identified a novel association with cigarettes-smoked-per-day upstream of the TMEM106B gene on chromosome 7p21.3 (rs148253479, P=3.18×10−8, n=3520). Results provide evidence of a partially shared genetic basis for schizophrenia and smoking behaviors. Additionally, genetic risk factors for smoking behaviors were largely shared across schizophrenia and non-schizophrenia populations. Future research should address mechanisms underlying these associations to aid both schizophrenia and smoking treatment and prevention efforts. DE-3 Urheberrechtsschutz 1.0 rs http://rightsstatements.org/vocab/InC/1.0/ Cigarettes per day Genetics GWAS Pleiotropy Schizophrenia Smoking initiation Bigdeli, Tim B. verfasserin aut Ripke, Stephan verfasserin aut Bacanu, Silviu-Alin verfasserin aut Gejman, Pablo V. verfasserin aut Levinson, Douglas F. verfasserin aut Li, Qingqin S. verfasserin aut Rujescu, Dan verfasserin (DE-588)110316516X (DE-627)860809110 (DE-576)470516747 aut Rietschel, Marcella 1957- verfasserin (DE-588)112785751 (DE-627)505574020 (DE-576)289742307 aut Weinberger, Daniel R. verfasserin aut Straub, Richard E. verfasserin aut Walters, James T. R. verfasserin aut Owen, Michael J. verfasserin aut O'Donovan, Michael C. verfasserin aut Mowry, Bryan J. verfasserin aut Ophoff, Roel A. verfasserin aut Andreassen, Ole A. verfasserin aut Esko, Tõnu verfasserin aut Petryshen, Tracey L. verfasserin aut Kendler, Kenneth S. verfasserin aut Fanous, Ayman H. verfasserin aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 137(2021) vom: Mai, Seite 215-224 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:137 year:2021 month:05 pages:215-224 extent:10 https://doi.org/10.1016/j.jpsychires.2021.02.027 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0022395621000947 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_64 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_2013 GBV_ILN_2013 ISIL_DE-16-250 AR 137 2021 5 215-224 10 64 01 3064 4104273511 x 28-03-22 2013 01 DE-16-250 3980328821 00 --%%-- --%%-- --%%-- --%%-- l01 22-09-21 64 00 3064 00 (DE-627)637334159 Universitätsklinik und Poliklinik für Psychiatrie, Psychotherapie und Psychosomatik <Halle, Saale> 64 00 3064 01 (DE-627)355383683 Zeitschrift 64 00 3064 02 (DE-627)355383330 Aufsatz 2013 01 DE-16-250 00 s hd2021 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_21 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1447886461 Rietschel, Marcella 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_9 64 01 3064 99 j2021 |
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10.1016/j.jpsychires.2021.02.027 doi (DE-627)177163846X (DE-599)KXP177163846X (OCoLC)1341421388 DE-627 ger DE-627 rda eng Peterson, Roseann E. verfasserin (DE-588)1199364185 (DE-627)1681643510 aut Genome-wide analyses of smoking behaviors in schizophrenia findings from the Psychiatric Genomics Consortium Roseann E. Peterson, Tim B. Bigdeli, Stephan Ripke, Silviu-Alin Bacanu, Pablo V. Gejman, Douglas F. Levinson, Qingqin S. Li, Dan Rujescu, Marcella Rietschel, Daniel R. Weinberger, Richard E. Straub, James T.R. Walters, Michael J. Owen, Michael C. O'Donovan, Bryan J. Mowry, Roel A. Ophoff, Ole A. Andreassen, Tõnu Esko, Tracey L. Petryshen, Kenneth S. Kendler, Ayman H. Fanous May 2021 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 22.09.2021 While 17% of US adults use tobacco regularly, smoking rates among persons with schizophrenia are upwards of 60%. Research supports a shared etiological basis for smoking and schizophrenia, including findings from genome-wide association studies (GWAS). However, few studies have directly tested whether the same or distinct genetic variants also influence smoking behavior among schizophrenia cases. Using data from the Psychiatric Genomics Consortium (PGC) study of schizophrenia (35476 cases, 46839 controls), we estimated genetic correlations between these traits and tested whether polygenic risk scores (PRS) constructed from the results of smoking behaviors GWAS were associated with schizophrenia risk or smoking behaviors among schizophrenia cases. Results indicated significant genetic correlations of schizophrenia with smoking initiation (rg=0.159; P=5.05×10−10), cigarettes-smoked-per-day (rg=0.094; P=0.006), and age-of-onset of smoking (rg=0.10; P=0.009). Comparing smoking behaviors among schizophrenia cases to the general population, we observe positive genetic correlations for smoking initiation (rg=0.624, P=0.002) and cigarettes-smoked-per-day (rg=0.689, P=0.120). Similarly, TAG-based PRS for smoking initiation and cigarettes-smoked-per-day were significantly associated with smoking initiation (P=3.49×10−5) and cigarettes-smoked-per-day (P=0.007) among schizophrenia cases. We performed the first GWAS of smoking behavior among schizophrenia cases and identified a novel association with cigarettes-smoked-per-day upstream of the TMEM106B gene on chromosome 7p21.3 (rs148253479, P=3.18×10−8, n=3520). Results provide evidence of a partially shared genetic basis for schizophrenia and smoking behaviors. Additionally, genetic risk factors for smoking behaviors were largely shared across schizophrenia and non-schizophrenia populations. Future research should address mechanisms underlying these associations to aid both schizophrenia and smoking treatment and prevention efforts. DE-3 Urheberrechtsschutz 1.0 rs http://rightsstatements.org/vocab/InC/1.0/ Cigarettes per day Genetics GWAS Pleiotropy Schizophrenia Smoking initiation Bigdeli, Tim B. verfasserin aut Ripke, Stephan verfasserin aut Bacanu, Silviu-Alin verfasserin aut Gejman, Pablo V. verfasserin aut Levinson, Douglas F. verfasserin aut Li, Qingqin S. verfasserin aut Rujescu, Dan verfasserin (DE-588)110316516X (DE-627)860809110 (DE-576)470516747 aut Rietschel, Marcella 1957- verfasserin (DE-588)112785751 (DE-627)505574020 (DE-576)289742307 aut Weinberger, Daniel R. verfasserin aut Straub, Richard E. verfasserin aut Walters, James T. R. verfasserin aut Owen, Michael J. verfasserin aut O'Donovan, Michael C. verfasserin aut Mowry, Bryan J. verfasserin aut Ophoff, Roel A. verfasserin aut Andreassen, Ole A. verfasserin aut Esko, Tõnu verfasserin aut Petryshen, Tracey L. verfasserin aut Kendler, Kenneth S. verfasserin aut Fanous, Ayman H. verfasserin aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 137(2021) vom: Mai, Seite 215-224 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:137 year:2021 month:05 pages:215-224 extent:10 https://doi.org/10.1016/j.jpsychires.2021.02.027 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0022395621000947 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_64 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_2013 GBV_ILN_2013 ISIL_DE-16-250 AR 137 2021 5 215-224 10 64 01 3064 4104273511 x 28-03-22 2013 01 DE-16-250 3980328821 00 --%%-- --%%-- --%%-- --%%-- l01 22-09-21 64 00 3064 00 (DE-627)637334159 Universitätsklinik und Poliklinik für Psychiatrie, Psychotherapie und Psychosomatik <Halle, Saale> 64 00 3064 01 (DE-627)355383683 Zeitschrift 64 00 3064 02 (DE-627)355383330 Aufsatz 2013 01 DE-16-250 00 s hd2021 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_21 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1447886461 Rietschel, Marcella 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_9 64 01 3064 99 j2021 |
| allfields_unstemmed |
10.1016/j.jpsychires.2021.02.027 doi (DE-627)177163846X (DE-599)KXP177163846X (OCoLC)1341421388 DE-627 ger DE-627 rda eng Peterson, Roseann E. verfasserin (DE-588)1199364185 (DE-627)1681643510 aut Genome-wide analyses of smoking behaviors in schizophrenia findings from the Psychiatric Genomics Consortium Roseann E. Peterson, Tim B. Bigdeli, Stephan Ripke, Silviu-Alin Bacanu, Pablo V. Gejman, Douglas F. Levinson, Qingqin S. Li, Dan Rujescu, Marcella Rietschel, Daniel R. Weinberger, Richard E. Straub, James T.R. Walters, Michael J. Owen, Michael C. O'Donovan, Bryan J. Mowry, Roel A. Ophoff, Ole A. Andreassen, Tõnu Esko, Tracey L. Petryshen, Kenneth S. Kendler, Ayman H. Fanous May 2021 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 22.09.2021 While 17% of US adults use tobacco regularly, smoking rates among persons with schizophrenia are upwards of 60%. Research supports a shared etiological basis for smoking and schizophrenia, including findings from genome-wide association studies (GWAS). However, few studies have directly tested whether the same or distinct genetic variants also influence smoking behavior among schizophrenia cases. Using data from the Psychiatric Genomics Consortium (PGC) study of schizophrenia (35476 cases, 46839 controls), we estimated genetic correlations between these traits and tested whether polygenic risk scores (PRS) constructed from the results of smoking behaviors GWAS were associated with schizophrenia risk or smoking behaviors among schizophrenia cases. Results indicated significant genetic correlations of schizophrenia with smoking initiation (rg=0.159; P=5.05×10−10), cigarettes-smoked-per-day (rg=0.094; P=0.006), and age-of-onset of smoking (rg=0.10; P=0.009). Comparing smoking behaviors among schizophrenia cases to the general population, we observe positive genetic correlations for smoking initiation (rg=0.624, P=0.002) and cigarettes-smoked-per-day (rg=0.689, P=0.120). Similarly, TAG-based PRS for smoking initiation and cigarettes-smoked-per-day were significantly associated with smoking initiation (P=3.49×10−5) and cigarettes-smoked-per-day (P=0.007) among schizophrenia cases. We performed the first GWAS of smoking behavior among schizophrenia cases and identified a novel association with cigarettes-smoked-per-day upstream of the TMEM106B gene on chromosome 7p21.3 (rs148253479, P=3.18×10−8, n=3520). Results provide evidence of a partially shared genetic basis for schizophrenia and smoking behaviors. Additionally, genetic risk factors for smoking behaviors were largely shared across schizophrenia and non-schizophrenia populations. Future research should address mechanisms underlying these associations to aid both schizophrenia and smoking treatment and prevention efforts. DE-3 Urheberrechtsschutz 1.0 rs http://rightsstatements.org/vocab/InC/1.0/ Cigarettes per day Genetics GWAS Pleiotropy Schizophrenia Smoking initiation Bigdeli, Tim B. verfasserin aut Ripke, Stephan verfasserin aut Bacanu, Silviu-Alin verfasserin aut Gejman, Pablo V. verfasserin aut Levinson, Douglas F. verfasserin aut Li, Qingqin S. verfasserin aut Rujescu, Dan verfasserin (DE-588)110316516X (DE-627)860809110 (DE-576)470516747 aut Rietschel, Marcella 1957- verfasserin (DE-588)112785751 (DE-627)505574020 (DE-576)289742307 aut Weinberger, Daniel R. verfasserin aut Straub, Richard E. verfasserin aut Walters, James T. R. verfasserin aut Owen, Michael J. verfasserin aut O'Donovan, Michael C. verfasserin aut Mowry, Bryan J. verfasserin aut Ophoff, Roel A. verfasserin aut Andreassen, Ole A. verfasserin aut Esko, Tõnu verfasserin aut Petryshen, Tracey L. verfasserin aut Kendler, Kenneth S. verfasserin aut Fanous, Ayman H. verfasserin aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 137(2021) vom: Mai, Seite 215-224 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:137 year:2021 month:05 pages:215-224 extent:10 https://doi.org/10.1016/j.jpsychires.2021.02.027 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0022395621000947 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_64 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_2013 GBV_ILN_2013 ISIL_DE-16-250 AR 137 2021 5 215-224 10 64 01 3064 4104273511 x 28-03-22 2013 01 DE-16-250 3980328821 00 --%%-- --%%-- --%%-- --%%-- l01 22-09-21 64 00 3064 00 (DE-627)637334159 Universitätsklinik und Poliklinik für Psychiatrie, Psychotherapie und Psychosomatik <Halle, Saale> 64 00 3064 01 (DE-627)355383683 Zeitschrift 64 00 3064 02 (DE-627)355383330 Aufsatz 2013 01 DE-16-250 00 s hd2021 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_21 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1447886461 Rietschel, Marcella 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_9 64 01 3064 99 j2021 |
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10.1016/j.jpsychires.2021.02.027 doi (DE-627)177163846X (DE-599)KXP177163846X (OCoLC)1341421388 DE-627 ger DE-627 rda eng Peterson, Roseann E. verfasserin (DE-588)1199364185 (DE-627)1681643510 aut Genome-wide analyses of smoking behaviors in schizophrenia findings from the Psychiatric Genomics Consortium Roseann E. Peterson, Tim B. Bigdeli, Stephan Ripke, Silviu-Alin Bacanu, Pablo V. Gejman, Douglas F. Levinson, Qingqin S. Li, Dan Rujescu, Marcella Rietschel, Daniel R. Weinberger, Richard E. Straub, James T.R. Walters, Michael J. Owen, Michael C. O'Donovan, Bryan J. Mowry, Roel A. Ophoff, Ole A. Andreassen, Tõnu Esko, Tracey L. Petryshen, Kenneth S. Kendler, Ayman H. Fanous May 2021 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 22.09.2021 While 17% of US adults use tobacco regularly, smoking rates among persons with schizophrenia are upwards of 60%. Research supports a shared etiological basis for smoking and schizophrenia, including findings from genome-wide association studies (GWAS). However, few studies have directly tested whether the same or distinct genetic variants also influence smoking behavior among schizophrenia cases. Using data from the Psychiatric Genomics Consortium (PGC) study of schizophrenia (35476 cases, 46839 controls), we estimated genetic correlations between these traits and tested whether polygenic risk scores (PRS) constructed from the results of smoking behaviors GWAS were associated with schizophrenia risk or smoking behaviors among schizophrenia cases. Results indicated significant genetic correlations of schizophrenia with smoking initiation (rg=0.159; P=5.05×10−10), cigarettes-smoked-per-day (rg=0.094; P=0.006), and age-of-onset of smoking (rg=0.10; P=0.009). Comparing smoking behaviors among schizophrenia cases to the general population, we observe positive genetic correlations for smoking initiation (rg=0.624, P=0.002) and cigarettes-smoked-per-day (rg=0.689, P=0.120). Similarly, TAG-based PRS for smoking initiation and cigarettes-smoked-per-day were significantly associated with smoking initiation (P=3.49×10−5) and cigarettes-smoked-per-day (P=0.007) among schizophrenia cases. We performed the first GWAS of smoking behavior among schizophrenia cases and identified a novel association with cigarettes-smoked-per-day upstream of the TMEM106B gene on chromosome 7p21.3 (rs148253479, P=3.18×10−8, n=3520). Results provide evidence of a partially shared genetic basis for schizophrenia and smoking behaviors. Additionally, genetic risk factors for smoking behaviors were largely shared across schizophrenia and non-schizophrenia populations. Future research should address mechanisms underlying these associations to aid both schizophrenia and smoking treatment and prevention efforts. DE-3 Urheberrechtsschutz 1.0 rs http://rightsstatements.org/vocab/InC/1.0/ Cigarettes per day Genetics GWAS Pleiotropy Schizophrenia Smoking initiation Bigdeli, Tim B. verfasserin aut Ripke, Stephan verfasserin aut Bacanu, Silviu-Alin verfasserin aut Gejman, Pablo V. verfasserin aut Levinson, Douglas F. verfasserin aut Li, Qingqin S. verfasserin aut Rujescu, Dan verfasserin (DE-588)110316516X (DE-627)860809110 (DE-576)470516747 aut Rietschel, Marcella 1957- verfasserin (DE-588)112785751 (DE-627)505574020 (DE-576)289742307 aut Weinberger, Daniel R. verfasserin aut Straub, Richard E. verfasserin aut Walters, James T. R. verfasserin aut Owen, Michael J. verfasserin aut O'Donovan, Michael C. verfasserin aut Mowry, Bryan J. verfasserin aut Ophoff, Roel A. verfasserin aut Andreassen, Ole A. verfasserin aut Esko, Tõnu verfasserin aut Petryshen, Tracey L. verfasserin aut Kendler, Kenneth S. verfasserin aut Fanous, Ayman H. verfasserin aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 137(2021) vom: Mai, Seite 215-224 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:137 year:2021 month:05 pages:215-224 extent:10 https://doi.org/10.1016/j.jpsychires.2021.02.027 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0022395621000947 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_64 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_2013 GBV_ILN_2013 ISIL_DE-16-250 AR 137 2021 5 215-224 10 64 01 3064 4104273511 x 28-03-22 2013 01 DE-16-250 3980328821 00 --%%-- --%%-- --%%-- --%%-- l01 22-09-21 64 00 3064 00 (DE-627)637334159 Universitätsklinik und Poliklinik für Psychiatrie, Psychotherapie und Psychosomatik <Halle, Saale> 64 00 3064 01 (DE-627)355383683 Zeitschrift 64 00 3064 02 (DE-627)355383330 Aufsatz 2013 01 DE-16-250 00 s hd2021 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_21 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1447886461 Rietschel, Marcella 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_9 64 01 3064 99 j2021 |
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10.1016/j.jpsychires.2021.02.027 doi (DE-627)177163846X (DE-599)KXP177163846X (OCoLC)1341421388 DE-627 ger DE-627 rda eng Peterson, Roseann E. verfasserin (DE-588)1199364185 (DE-627)1681643510 aut Genome-wide analyses of smoking behaviors in schizophrenia findings from the Psychiatric Genomics Consortium Roseann E. Peterson, Tim B. Bigdeli, Stephan Ripke, Silviu-Alin Bacanu, Pablo V. Gejman, Douglas F. Levinson, Qingqin S. Li, Dan Rujescu, Marcella Rietschel, Daniel R. Weinberger, Richard E. Straub, James T.R. Walters, Michael J. Owen, Michael C. O'Donovan, Bryan J. Mowry, Roel A. Ophoff, Ole A. Andreassen, Tõnu Esko, Tracey L. Petryshen, Kenneth S. Kendler, Ayman H. Fanous May 2021 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 22.09.2021 While 17% of US adults use tobacco regularly, smoking rates among persons with schizophrenia are upwards of 60%. Research supports a shared etiological basis for smoking and schizophrenia, including findings from genome-wide association studies (GWAS). However, few studies have directly tested whether the same or distinct genetic variants also influence smoking behavior among schizophrenia cases. Using data from the Psychiatric Genomics Consortium (PGC) study of schizophrenia (35476 cases, 46839 controls), we estimated genetic correlations between these traits and tested whether polygenic risk scores (PRS) constructed from the results of smoking behaviors GWAS were associated with schizophrenia risk or smoking behaviors among schizophrenia cases. Results indicated significant genetic correlations of schizophrenia with smoking initiation (rg=0.159; P=5.05×10−10), cigarettes-smoked-per-day (rg=0.094; P=0.006), and age-of-onset of smoking (rg=0.10; P=0.009). Comparing smoking behaviors among schizophrenia cases to the general population, we observe positive genetic correlations for smoking initiation (rg=0.624, P=0.002) and cigarettes-smoked-per-day (rg=0.689, P=0.120). Similarly, TAG-based PRS for smoking initiation and cigarettes-smoked-per-day were significantly associated with smoking initiation (P=3.49×10−5) and cigarettes-smoked-per-day (P=0.007) among schizophrenia cases. We performed the first GWAS of smoking behavior among schizophrenia cases and identified a novel association with cigarettes-smoked-per-day upstream of the TMEM106B gene on chromosome 7p21.3 (rs148253479, P=3.18×10−8, n=3520). Results provide evidence of a partially shared genetic basis for schizophrenia and smoking behaviors. Additionally, genetic risk factors for smoking behaviors were largely shared across schizophrenia and non-schizophrenia populations. Future research should address mechanisms underlying these associations to aid both schizophrenia and smoking treatment and prevention efforts. DE-3 Urheberrechtsschutz 1.0 rs http://rightsstatements.org/vocab/InC/1.0/ Cigarettes per day Genetics GWAS Pleiotropy Schizophrenia Smoking initiation Bigdeli, Tim B. verfasserin aut Ripke, Stephan verfasserin aut Bacanu, Silviu-Alin verfasserin aut Gejman, Pablo V. verfasserin aut Levinson, Douglas F. verfasserin aut Li, Qingqin S. verfasserin aut Rujescu, Dan verfasserin (DE-588)110316516X (DE-627)860809110 (DE-576)470516747 aut Rietschel, Marcella 1957- verfasserin (DE-588)112785751 (DE-627)505574020 (DE-576)289742307 aut Weinberger, Daniel R. verfasserin aut Straub, Richard E. verfasserin aut Walters, James T. R. verfasserin aut Owen, Michael J. verfasserin aut O'Donovan, Michael C. verfasserin aut Mowry, Bryan J. verfasserin aut Ophoff, Roel A. verfasserin aut Andreassen, Ole A. verfasserin aut Esko, Tõnu verfasserin aut Petryshen, Tracey L. verfasserin aut Kendler, Kenneth S. verfasserin aut Fanous, Ayman H. verfasserin aut Enthalten in Journal of psychiatric research Amsterdam [u.a.] : Elsevier Science, 1961 137(2021) vom: Mai, Seite 215-224 Online-Ressource (DE-627)30666111X (DE-600)1500641-4 (DE-576)081986718 1879-1379 nnns volume:137 year:2021 month:05 pages:215-224 extent:10 https://doi.org/10.1016/j.jpsychires.2021.02.027 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0022395621000947 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_64 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_2013 GBV_ILN_2013 ISIL_DE-16-250 AR 137 2021 5 215-224 10 64 01 3064 4104273511 x 28-03-22 2013 01 DE-16-250 3980328821 00 --%%-- --%%-- --%%-- --%%-- l01 22-09-21 64 00 3064 00 (DE-627)637334159 Universitätsklinik und Poliklinik für Psychiatrie, Psychotherapie und Psychosomatik <Halle, Saale> 64 00 3064 01 (DE-627)355383683 Zeitschrift 64 00 3064 02 (DE-627)355383330 Aufsatz 2013 01 DE-16-250 00 s hd2021 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_21 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1447886461 Rietschel, Marcella 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_9 64 01 3064 99 j2021 |
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Enthalten in Journal of psychiatric research 137(2021) vom: Mai, Seite 215-224 volume:137 year:2021 month:05 pages:215-224 extent:10 |
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Peterson, Roseann E. @@aut@@ Bigdeli, Tim B. @@aut@@ Ripke, Stephan @@aut@@ Bacanu, Silviu-Alin @@aut@@ Gejman, Pablo V. @@aut@@ Levinson, Douglas F. @@aut@@ Li, Qingqin S. @@aut@@ Rujescu, Dan @@aut@@ Rietschel, Marcella @@aut@@ Weinberger, Daniel R. @@aut@@ Straub, Richard E. @@aut@@ Walters, James T. R. @@aut@@ Owen, Michael J. @@aut@@ O'Donovan, Michael C. @@aut@@ Mowry, Bryan J. @@aut@@ Ophoff, Roel A. @@aut@@ Andreassen, Ole A. @@aut@@ Esko, Tõnu @@aut@@ Petryshen, Tracey L. @@aut@@ Kendler, Kenneth S. @@aut@@ Fanous, Ayman H. @@aut@@ |
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Peterson, Tim B. Bigdeli, Stephan Ripke, Silviu-Alin Bacanu, Pablo V. Gejman, Douglas F. Levinson, Qingqin S. Li, Dan Rujescu, Marcella Rietschel, Daniel R. Weinberger, Richard E. Straub, James T.R. Walters, Michael J. Owen, Michael C. O'Donovan, Bryan J. Mowry, Roel A. Ophoff, Ole A. Andreassen, Tõnu Esko, Tracey L. Petryshen, Kenneth S. Kendler, Ayman H. Fanous</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">May 2021</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">10</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Gesehen am 22.09.2021</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">While 17% of US adults use tobacco regularly, smoking rates among persons with schizophrenia are upwards of 60%. 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Genome-wide analyses of smoking behaviors in schizophrenia findings from the Psychiatric Genomics Consortium Roseann E. Peterson, Tim B. Bigdeli, Stephan Ripke, Silviu-Alin Bacanu, Pablo V. Gejman, Douglas F. Levinson, Qingqin S. Li, Dan Rujescu, Marcella Rietschel, Daniel R. Weinberger, Richard E. Straub, James T.R. Walters, Michael J. Owen, Michael C. O'Donovan, Bryan J. Mowry, Roel A. Ophoff, Ole A. Andreassen, Tõnu Esko, Tracey L. Petryshen, Kenneth S. Kendler, Ayman H. Fanous |
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genome-wide analyses of smoking behaviors in schizophreniafindings from the psychiatric genomics consortium |
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Genome-wide analyses of smoking behaviors in schizophrenia findings from the Psychiatric Genomics Consortium |
| abstract |
While 17% of US adults use tobacco regularly, smoking rates among persons with schizophrenia are upwards of 60%. Research supports a shared etiological basis for smoking and schizophrenia, including findings from genome-wide association studies (GWAS). However, few studies have directly tested whether the same or distinct genetic variants also influence smoking behavior among schizophrenia cases. Using data from the Psychiatric Genomics Consortium (PGC) study of schizophrenia (35476 cases, 46839 controls), we estimated genetic correlations between these traits and tested whether polygenic risk scores (PRS) constructed from the results of smoking behaviors GWAS were associated with schizophrenia risk or smoking behaviors among schizophrenia cases. Results indicated significant genetic correlations of schizophrenia with smoking initiation (rg=0.159; P=5.05×10−10), cigarettes-smoked-per-day (rg=0.094; P=0.006), and age-of-onset of smoking (rg=0.10; P=0.009). Comparing smoking behaviors among schizophrenia cases to the general population, we observe positive genetic correlations for smoking initiation (rg=0.624, P=0.002) and cigarettes-smoked-per-day (rg=0.689, P=0.120). Similarly, TAG-based PRS for smoking initiation and cigarettes-smoked-per-day were significantly associated with smoking initiation (P=3.49×10−5) and cigarettes-smoked-per-day (P=0.007) among schizophrenia cases. We performed the first GWAS of smoking behavior among schizophrenia cases and identified a novel association with cigarettes-smoked-per-day upstream of the TMEM106B gene on chromosome 7p21.3 (rs148253479, P=3.18×10−8, n=3520). Results provide evidence of a partially shared genetic basis for schizophrenia and smoking behaviors. Additionally, genetic risk factors for smoking behaviors were largely shared across schizophrenia and non-schizophrenia populations. Future research should address mechanisms underlying these associations to aid both schizophrenia and smoking treatment and prevention efforts. Gesehen am 22.09.2021 |
| abstractGer |
While 17% of US adults use tobacco regularly, smoking rates among persons with schizophrenia are upwards of 60%. Research supports a shared etiological basis for smoking and schizophrenia, including findings from genome-wide association studies (GWAS). However, few studies have directly tested whether the same or distinct genetic variants also influence smoking behavior among schizophrenia cases. Using data from the Psychiatric Genomics Consortium (PGC) study of schizophrenia (35476 cases, 46839 controls), we estimated genetic correlations between these traits and tested whether polygenic risk scores (PRS) constructed from the results of smoking behaviors GWAS were associated with schizophrenia risk or smoking behaviors among schizophrenia cases. Results indicated significant genetic correlations of schizophrenia with smoking initiation (rg=0.159; P=5.05×10−10), cigarettes-smoked-per-day (rg=0.094; P=0.006), and age-of-onset of smoking (rg=0.10; P=0.009). Comparing smoking behaviors among schizophrenia cases to the general population, we observe positive genetic correlations for smoking initiation (rg=0.624, P=0.002) and cigarettes-smoked-per-day (rg=0.689, P=0.120). Similarly, TAG-based PRS for smoking initiation and cigarettes-smoked-per-day were significantly associated with smoking initiation (P=3.49×10−5) and cigarettes-smoked-per-day (P=0.007) among schizophrenia cases. We performed the first GWAS of smoking behavior among schizophrenia cases and identified a novel association with cigarettes-smoked-per-day upstream of the TMEM106B gene on chromosome 7p21.3 (rs148253479, P=3.18×10−8, n=3520). Results provide evidence of a partially shared genetic basis for schizophrenia and smoking behaviors. Additionally, genetic risk factors for smoking behaviors were largely shared across schizophrenia and non-schizophrenia populations. Future research should address mechanisms underlying these associations to aid both schizophrenia and smoking treatment and prevention efforts. Gesehen am 22.09.2021 |
| abstract_unstemmed |
While 17% of US adults use tobacco regularly, smoking rates among persons with schizophrenia are upwards of 60%. Research supports a shared etiological basis for smoking and schizophrenia, including findings from genome-wide association studies (GWAS). However, few studies have directly tested whether the same or distinct genetic variants also influence smoking behavior among schizophrenia cases. Using data from the Psychiatric Genomics Consortium (PGC) study of schizophrenia (35476 cases, 46839 controls), we estimated genetic correlations between these traits and tested whether polygenic risk scores (PRS) constructed from the results of smoking behaviors GWAS were associated with schizophrenia risk or smoking behaviors among schizophrenia cases. Results indicated significant genetic correlations of schizophrenia with smoking initiation (rg=0.159; P=5.05×10−10), cigarettes-smoked-per-day (rg=0.094; P=0.006), and age-of-onset of smoking (rg=0.10; P=0.009). Comparing smoking behaviors among schizophrenia cases to the general population, we observe positive genetic correlations for smoking initiation (rg=0.624, P=0.002) and cigarettes-smoked-per-day (rg=0.689, P=0.120). Similarly, TAG-based PRS for smoking initiation and cigarettes-smoked-per-day were significantly associated with smoking initiation (P=3.49×10−5) and cigarettes-smoked-per-day (P=0.007) among schizophrenia cases. We performed the first GWAS of smoking behavior among schizophrenia cases and identified a novel association with cigarettes-smoked-per-day upstream of the TMEM106B gene on chromosome 7p21.3 (rs148253479, P=3.18×10−8, n=3520). Results provide evidence of a partially shared genetic basis for schizophrenia and smoking behaviors. Additionally, genetic risk factors for smoking behaviors were largely shared across schizophrenia and non-schizophrenia populations. Future research should address mechanisms underlying these associations to aid both schizophrenia and smoking treatment and prevention efforts. Gesehen am 22.09.2021 |
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Genome-wide analyses of smoking behaviors in schizophrenia |
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Bigdeli, Tim B. Ripke, Stephan Bacanu, Silviu-Alin Gejman, Pablo V. Levinson, Douglas F. Li, Qingqin S. Rujescu, Dan Rietschel, Marcella 1957- Weinberger, Daniel R. Straub, Richard E. Walters, James T. R. Owen, Michael J. O'Donovan, Michael C. Mowry, Bryan J. Ophoff, Roel A. Andreassen, Ole A. Esko, Tõnu Petryshen, Tracey L. Kendler, Kenneth S. Fanous, Ayman H. |
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