Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer
HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we com...
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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Published 27 March 2013 Gesehen am 24.01.2022 |
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| Umfang: |
10 |
| Übergeordnetes Werk: |
Enthalten in: Nature Communications - [London] : Springer Nature, 2010, 4(2013), Artikel-ID 1628, Seite 1-10 |
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| Übergeordnetes Werk: |
volume:4 ; year:2013 ; elocationid:1628 ; pages:1-10 ; extent:10 |
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| DOI / URN: |
10.1038/ncomms2629 |
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1787027686 |
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| 100 | 1 | |a Shen, Hui |e verfasserin |0 (DE-588)1228750769 |0 (DE-627)1750721686 |4 aut | |
| 245 | 1 | 0 | |a Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer |c Hui Shen, Brooke L. Fridley, Honglin Song et al. |
| 264 | 1 | |c 2013 | |
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| 500 | |a Gesehen am 24.01.2022 | ||
| 520 | |a HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we comprehensively map variation in HNF1B with respect to epithelial ovarian cancer risk and analyse DNA methylation and expression profiles across histological subtypes. Different single-nucleotide polymorphisms associate with invasive serous (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10−10) and clear cell (rs11651755 OR=0.77, P=1.6 × 10−8) epithelial ovarian cancer. Risk alleles for the serous subtype associate with higher HNF1B-promoter methylation in these tumours. Unmethylated, expressed HNF1B, primarily present in clear cell tumours, coincides with a CpG island methylator phenotype affecting numerous other promoters throughout the genome. Different variants in HNF1B associate with risk of serous and clear cell epithelial ovarian cancer; DNA methylation and expression patterns are also notably distinct between these subtypes. These findings underscore distinct mechanisms driving different epithelial ovarian cancer histological subtypes. | ||
| 650 | 4 | |a Cancer genetics | |
| 650 | 4 | |a Epigenetics analysis | |
| 650 | 4 | |a Ovarian cancer | |
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10.1038/ncomms2629 doi (DE-627)1787027686 (DE-599)KXP1787027686 (OCoLC)1341438994 DE-627 ger DE-627 rda eng Shen, Hui verfasserin (DE-588)1228750769 (DE-627)1750721686 aut Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer Hui Shen, Brooke L. Fridley, Honglin Song et al. 2013 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Published 27 March 2013 Gesehen am 24.01.2022 HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we comprehensively map variation in HNF1B with respect to epithelial ovarian cancer risk and analyse DNA methylation and expression profiles across histological subtypes. Different single-nucleotide polymorphisms associate with invasive serous (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10−10) and clear cell (rs11651755 OR=0.77, P=1.6 × 10−8) epithelial ovarian cancer. Risk alleles for the serous subtype associate with higher HNF1B-promoter methylation in these tumours. Unmethylated, expressed HNF1B, primarily present in clear cell tumours, coincides with a CpG island methylator phenotype affecting numerous other promoters throughout the genome. Different variants in HNF1B associate with risk of serous and clear cell epithelial ovarian cancer; DNA methylation and expression patterns are also notably distinct between these subtypes. These findings underscore distinct mechanisms driving different epithelial ovarian cancer histological subtypes. Cancer genetics Epigenetics analysis Ovarian cancer Fridley, Brooke L. verfasserin aut Song, Honglin verfasserin aut Lawrenson, Kate verfasserin aut Cunningham, Julie M. verfasserin aut Ramus, Susan J. verfasserin aut Cicek, Mine S. verfasserin aut Tyrer, Jonathan verfasserin aut Stram, Douglas verfasserin aut Larson, Melissa C. verfasserin aut Köbel, Martin verfasserin aut Ziogas, Argyrios verfasserin aut Zheng, Wei verfasserin aut Yang, Hannah P. verfasserin aut Wu, Anna H. verfasserin aut Wozniak, Eva L. verfasserin aut Ling Woo, Yin verfasserin aut Winterhoff, Boris verfasserin aut Wik, Elisabeth verfasserin aut Whittemore, Alice S. verfasserin aut Wentzensen, Nicolas verfasserin aut Palmieri Weber, Rachel verfasserin aut Vitonis, Allison F. verfasserin aut Vincent, Daniel verfasserin aut Vierkant, Robert A. verfasserin aut Vergote, Ignace verfasserin aut Van Den Berg, David verfasserin aut Van Altena, Anne M. verfasserin aut Tworoger, Shelley S. verfasserin aut Thompson, Pamela J. verfasserin aut Tessier, Daniel C. verfasserin aut Terry, Kathryn L. verfasserin aut Teo, Soo-Hwang verfasserin aut Templeman, Claire verfasserin aut Stram, Daniel O. verfasserin aut Southey, Melissa C. verfasserin aut Sieh, Weiva verfasserin aut Siddiqui, Nadeem verfasserin aut Shvetsov, Yurii B. verfasserin aut Shu, Xiao-Ou verfasserin aut Shridhar, Viji verfasserin aut Wang-Gohrke, Shan verfasserin aut Severi, Gianluca verfasserin aut Schwaab, Ira verfasserin aut Salvesen, Helga B. verfasserin aut Rzepecka, Iwona K. verfasserin aut Runnebaum, Ingo B. verfasserin aut Anne Rossing, Mary verfasserin aut Rodriguez-Rodriguez, Lorna verfasserin aut Risch, Harvey A. verfasserin aut Renner, Stefan P. verfasserin aut Poole, Elizabeth M. verfasserin aut Pike, Malcolm C. verfasserin aut Phelan, Catherine M. verfasserin aut Pelttari, Liisa M. verfasserin aut Pejovic, Tanja verfasserin aut Paul, James verfasserin aut Orlow, Irene verfasserin aut Zawiah Omar, Siti verfasserin aut Olson, Sara H. verfasserin aut Odunsi, Kunle verfasserin aut Nickels, Stefan verfasserin aut Nevanlinna, Heli verfasserin aut Ness, Roberta B. verfasserin aut Narod, Steven A. verfasserin aut Nakanishi, Toru verfasserin aut Moysich, Kirsten B. verfasserin aut Monteiro, Alvaro N. A. verfasserin aut Moes-Sosnowska, Joanna verfasserin aut Modugno, Francesmary verfasserin aut Menon, Usha verfasserin aut McLaughlin, John R. verfasserin aut McGuire, Valerie verfasserin aut Matsuo, Keitaro verfasserin aut Mat Adenan, Noor Azmi verfasserin aut Massuger, Leon F. A. G. verfasserin aut Lurie, Galina verfasserin aut Lundvall, Lene verfasserin aut Lubiński, Jan verfasserin aut Lissowska, Jolanta verfasserin aut Levine, Douglas A. verfasserin aut Leminen, Arto verfasserin aut Lee, Alice W. verfasserin aut Le, Nhu D. verfasserin aut Lambrechts, Sandrina verfasserin aut Lambrechts, Diether verfasserin aut Kupryjanczyk, Jolanta verfasserin aut Krakstad, Camilla verfasserin aut Konecny, Gottfried E. verfasserin aut Krüger Kjaer, Susanne verfasserin aut Kiemeney, Lambertus A. verfasserin aut Kelemen, Linda E. verfasserin aut Keeney, Gary L. verfasserin aut Karlan, Beth Y. verfasserin aut Karevan, Rod verfasserin aut Kalli, Kimberly R. verfasserin aut Kajiyama, Hiroaki verfasserin aut Ji, Bu-Tian verfasserin aut Jensen, Allan verfasserin aut Jakubowska, Anna verfasserin aut Iversen, Edwin verfasserin aut Hosono, Satoyo verfasserin aut Høgdall, Claus K. verfasserin aut Høgdall, Estrid verfasserin aut Hoatlin, Maureen verfasserin aut Hillemanns, Peter verfasserin aut Heitz, Florian verfasserin aut Hein, Rebecca verfasserin aut Harter, Philipp verfasserin aut Halle, Mari K. verfasserin aut Hall, Per verfasserin aut Gronwald, Jacek verfasserin aut Gore, Martin verfasserin aut Goodman, Marc T. verfasserin aut Giles, Graham G. verfasserin aut Gentry-Maharaj, Aleksandra verfasserin aut Garcia-Closas, Montserrat verfasserin aut Flanagan, James M. verfasserin aut Fasching, Peter A. verfasserin aut Ekici, Arif B. verfasserin aut Edwards, Robert verfasserin aut Eccles, Diana verfasserin aut Easton, Douglas F. verfasserin aut Dürst, Matthias verfasserin aut du Bois, Andreas verfasserin aut Dörk, Thilo verfasserin aut Doherty, Jennifer A. verfasserin aut Despierre, Evelyn verfasserin aut Dansonka-Mieszkowska, Agnieszka verfasserin aut Cybulski, Cezary verfasserin aut Cramer, Daniel W. verfasserin aut Cook, Linda S. verfasserin aut Chen, Xiaoqing verfasserin aut Charbonneau, Bridget verfasserin aut Chang-Claude, Jenny verfasserin (DE-588)1049304993 (DE-627)781626188 (DE-576)168344475 aut Campbell, Ian verfasserin aut Butzow, Ralf verfasserin aut Bunker, Clareann H. verfasserin aut Brueggmann, Doerthe verfasserin aut Brown, Robert verfasserin aut Brooks-Wilson, Angela verfasserin aut Brinton, Louise A. verfasserin aut Bogdanova, Natalia verfasserin aut Block, Matthew S. verfasserin aut Benjamin, Elizabeth verfasserin aut Beesley, Jonathan verfasserin aut Beckmann, Matthias W. verfasserin aut Bandera, Elisa V. verfasserin aut Baglietto, Laura verfasserin aut Bacot, François verfasserin aut Armasu, Sebastian M. verfasserin aut Antonenkova, Natalia verfasserin aut Anton-Culver, Hoda verfasserin aut Aben, Katja K. verfasserin aut Liang, Dong verfasserin aut Wu, Xifeng verfasserin aut Lu, Karen verfasserin aut Hildebrandt, Michelle A. T. verfasserin aut Schildkraut, Joellen M. verfasserin aut Sellers, Thomas A. verfasserin aut Huntsman, David verfasserin aut Berchuck, Andrew verfasserin aut Chenevix-Trench, Georgia verfasserin aut Gayther, Simon A. verfasserin aut Pharoah, Paul D. P. verfasserin aut Laird, Peter W. verfasserin aut Goode, Ellen L. verfasserin aut Leigh Pearce, Celeste verfasserin aut Enthalten in Nature Communications [London] : Springer Nature, 2010 4(2013), Artikel-ID 1628, Seite 1-10 Online-Ressource (DE-627)626457688 (DE-600)2553671-0 (DE-576)331555905 2041-1723 nnns volume:4 year:2013 elocationid:1628 pages:1-10 extent:10 https://doi.org/10.1038/ncomms2629 Verlag Resolving-System lizenzpflichtig Volltext https://www.nature.com/articles/ncomms2629 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 1628 1-10 10 2013 01 DE-16-250 4042340857 00 --%%-- --%%-- --%%-- --%%-- l01 24-01-22 2013 01 DE-16-250 00 s hd2013 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_168 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1473283485 Chang-Claude, Jenny 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_135 |
| spelling |
10.1038/ncomms2629 doi (DE-627)1787027686 (DE-599)KXP1787027686 (OCoLC)1341438994 DE-627 ger DE-627 rda eng Shen, Hui verfasserin (DE-588)1228750769 (DE-627)1750721686 aut Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer Hui Shen, Brooke L. Fridley, Honglin Song et al. 2013 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Published 27 March 2013 Gesehen am 24.01.2022 HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we comprehensively map variation in HNF1B with respect to epithelial ovarian cancer risk and analyse DNA methylation and expression profiles across histological subtypes. Different single-nucleotide polymorphisms associate with invasive serous (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10−10) and clear cell (rs11651755 OR=0.77, P=1.6 × 10−8) epithelial ovarian cancer. Risk alleles for the serous subtype associate with higher HNF1B-promoter methylation in these tumours. Unmethylated, expressed HNF1B, primarily present in clear cell tumours, coincides with a CpG island methylator phenotype affecting numerous other promoters throughout the genome. Different variants in HNF1B associate with risk of serous and clear cell epithelial ovarian cancer; DNA methylation and expression patterns are also notably distinct between these subtypes. These findings underscore distinct mechanisms driving different epithelial ovarian cancer histological subtypes. Cancer genetics Epigenetics analysis Ovarian cancer Fridley, Brooke L. verfasserin aut Song, Honglin verfasserin aut Lawrenson, Kate verfasserin aut Cunningham, Julie M. verfasserin aut Ramus, Susan J. verfasserin aut Cicek, Mine S. verfasserin aut Tyrer, Jonathan verfasserin aut Stram, Douglas verfasserin aut Larson, Melissa C. verfasserin aut Köbel, Martin verfasserin aut Ziogas, Argyrios verfasserin aut Zheng, Wei verfasserin aut Yang, Hannah P. verfasserin aut Wu, Anna H. verfasserin aut Wozniak, Eva L. verfasserin aut Ling Woo, Yin verfasserin aut Winterhoff, Boris verfasserin aut Wik, Elisabeth verfasserin aut Whittemore, Alice S. verfasserin aut Wentzensen, Nicolas verfasserin aut Palmieri Weber, Rachel verfasserin aut Vitonis, Allison F. verfasserin aut Vincent, Daniel verfasserin aut Vierkant, Robert A. verfasserin aut Vergote, Ignace verfasserin aut Van Den Berg, David verfasserin aut Van Altena, Anne M. verfasserin aut Tworoger, Shelley S. verfasserin aut Thompson, Pamela J. verfasserin aut Tessier, Daniel C. verfasserin aut Terry, Kathryn L. verfasserin aut Teo, Soo-Hwang verfasserin aut Templeman, Claire verfasserin aut Stram, Daniel O. verfasserin aut Southey, Melissa C. verfasserin aut Sieh, Weiva verfasserin aut Siddiqui, Nadeem verfasserin aut Shvetsov, Yurii B. verfasserin aut Shu, Xiao-Ou verfasserin aut Shridhar, Viji verfasserin aut Wang-Gohrke, Shan verfasserin aut Severi, Gianluca verfasserin aut Schwaab, Ira verfasserin aut Salvesen, Helga B. verfasserin aut Rzepecka, Iwona K. verfasserin aut Runnebaum, Ingo B. verfasserin aut Anne Rossing, Mary verfasserin aut Rodriguez-Rodriguez, Lorna verfasserin aut Risch, Harvey A. verfasserin aut Renner, Stefan P. verfasserin aut Poole, Elizabeth M. verfasserin aut Pike, Malcolm C. verfasserin aut Phelan, Catherine M. verfasserin aut Pelttari, Liisa M. verfasserin aut Pejovic, Tanja verfasserin aut Paul, James verfasserin aut Orlow, Irene verfasserin aut Zawiah Omar, Siti verfasserin aut Olson, Sara H. verfasserin aut Odunsi, Kunle verfasserin aut Nickels, Stefan verfasserin aut Nevanlinna, Heli verfasserin aut Ness, Roberta B. verfasserin aut Narod, Steven A. verfasserin aut Nakanishi, Toru verfasserin aut Moysich, Kirsten B. verfasserin aut Monteiro, Alvaro N. A. verfasserin aut Moes-Sosnowska, Joanna verfasserin aut Modugno, Francesmary verfasserin aut Menon, Usha verfasserin aut McLaughlin, John R. verfasserin aut McGuire, Valerie verfasserin aut Matsuo, Keitaro verfasserin aut Mat Adenan, Noor Azmi verfasserin aut Massuger, Leon F. A. G. verfasserin aut Lurie, Galina verfasserin aut Lundvall, Lene verfasserin aut Lubiński, Jan verfasserin aut Lissowska, Jolanta verfasserin aut Levine, Douglas A. verfasserin aut Leminen, Arto verfasserin aut Lee, Alice W. verfasserin aut Le, Nhu D. verfasserin aut Lambrechts, Sandrina verfasserin aut Lambrechts, Diether verfasserin aut Kupryjanczyk, Jolanta verfasserin aut Krakstad, Camilla verfasserin aut Konecny, Gottfried E. verfasserin aut Krüger Kjaer, Susanne verfasserin aut Kiemeney, Lambertus A. verfasserin aut Kelemen, Linda E. verfasserin aut Keeney, Gary L. verfasserin aut Karlan, Beth Y. verfasserin aut Karevan, Rod verfasserin aut Kalli, Kimberly R. verfasserin aut Kajiyama, Hiroaki verfasserin aut Ji, Bu-Tian verfasserin aut Jensen, Allan verfasserin aut Jakubowska, Anna verfasserin aut Iversen, Edwin verfasserin aut Hosono, Satoyo verfasserin aut Høgdall, Claus K. verfasserin aut Høgdall, Estrid verfasserin aut Hoatlin, Maureen verfasserin aut Hillemanns, Peter verfasserin aut Heitz, Florian verfasserin aut Hein, Rebecca verfasserin aut Harter, Philipp verfasserin aut Halle, Mari K. verfasserin aut Hall, Per verfasserin aut Gronwald, Jacek verfasserin aut Gore, Martin verfasserin aut Goodman, Marc T. verfasserin aut Giles, Graham G. verfasserin aut Gentry-Maharaj, Aleksandra verfasserin aut Garcia-Closas, Montserrat verfasserin aut Flanagan, James M. verfasserin aut Fasching, Peter A. verfasserin aut Ekici, Arif B. verfasserin aut Edwards, Robert verfasserin aut Eccles, Diana verfasserin aut Easton, Douglas F. verfasserin aut Dürst, Matthias verfasserin aut du Bois, Andreas verfasserin aut Dörk, Thilo verfasserin aut Doherty, Jennifer A. verfasserin aut Despierre, Evelyn verfasserin aut Dansonka-Mieszkowska, Agnieszka verfasserin aut Cybulski, Cezary verfasserin aut Cramer, Daniel W. verfasserin aut Cook, Linda S. verfasserin aut Chen, Xiaoqing verfasserin aut Charbonneau, Bridget verfasserin aut Chang-Claude, Jenny verfasserin (DE-588)1049304993 (DE-627)781626188 (DE-576)168344475 aut Campbell, Ian verfasserin aut Butzow, Ralf verfasserin aut Bunker, Clareann H. verfasserin aut Brueggmann, Doerthe verfasserin aut Brown, Robert verfasserin aut Brooks-Wilson, Angela verfasserin aut Brinton, Louise A. verfasserin aut Bogdanova, Natalia verfasserin aut Block, Matthew S. verfasserin aut Benjamin, Elizabeth verfasserin aut Beesley, Jonathan verfasserin aut Beckmann, Matthias W. verfasserin aut Bandera, Elisa V. verfasserin aut Baglietto, Laura verfasserin aut Bacot, François verfasserin aut Armasu, Sebastian M. verfasserin aut Antonenkova, Natalia verfasserin aut Anton-Culver, Hoda verfasserin aut Aben, Katja K. verfasserin aut Liang, Dong verfasserin aut Wu, Xifeng verfasserin aut Lu, Karen verfasserin aut Hildebrandt, Michelle A. T. verfasserin aut Schildkraut, Joellen M. verfasserin aut Sellers, Thomas A. verfasserin aut Huntsman, David verfasserin aut Berchuck, Andrew verfasserin aut Chenevix-Trench, Georgia verfasserin aut Gayther, Simon A. verfasserin aut Pharoah, Paul D. P. verfasserin aut Laird, Peter W. verfasserin aut Goode, Ellen L. verfasserin aut Leigh Pearce, Celeste verfasserin aut Enthalten in Nature Communications [London] : Springer Nature, 2010 4(2013), Artikel-ID 1628, Seite 1-10 Online-Ressource (DE-627)626457688 (DE-600)2553671-0 (DE-576)331555905 2041-1723 nnns volume:4 year:2013 elocationid:1628 pages:1-10 extent:10 https://doi.org/10.1038/ncomms2629 Verlag Resolving-System lizenzpflichtig Volltext https://www.nature.com/articles/ncomms2629 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 1628 1-10 10 2013 01 DE-16-250 4042340857 00 --%%-- --%%-- --%%-- --%%-- l01 24-01-22 2013 01 DE-16-250 00 s hd2013 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_168 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1473283485 Chang-Claude, Jenny 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_135 |
| allfields_unstemmed |
10.1038/ncomms2629 doi (DE-627)1787027686 (DE-599)KXP1787027686 (OCoLC)1341438994 DE-627 ger DE-627 rda eng Shen, Hui verfasserin (DE-588)1228750769 (DE-627)1750721686 aut Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer Hui Shen, Brooke L. Fridley, Honglin Song et al. 2013 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Published 27 March 2013 Gesehen am 24.01.2022 HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we comprehensively map variation in HNF1B with respect to epithelial ovarian cancer risk and analyse DNA methylation and expression profiles across histological subtypes. Different single-nucleotide polymorphisms associate with invasive serous (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10−10) and clear cell (rs11651755 OR=0.77, P=1.6 × 10−8) epithelial ovarian cancer. Risk alleles for the serous subtype associate with higher HNF1B-promoter methylation in these tumours. Unmethylated, expressed HNF1B, primarily present in clear cell tumours, coincides with a CpG island methylator phenotype affecting numerous other promoters throughout the genome. Different variants in HNF1B associate with risk of serous and clear cell epithelial ovarian cancer; DNA methylation and expression patterns are also notably distinct between these subtypes. These findings underscore distinct mechanisms driving different epithelial ovarian cancer histological subtypes. Cancer genetics Epigenetics analysis Ovarian cancer Fridley, Brooke L. verfasserin aut Song, Honglin verfasserin aut Lawrenson, Kate verfasserin aut Cunningham, Julie M. verfasserin aut Ramus, Susan J. verfasserin aut Cicek, Mine S. verfasserin aut Tyrer, Jonathan verfasserin aut Stram, Douglas verfasserin aut Larson, Melissa C. verfasserin aut Köbel, Martin verfasserin aut Ziogas, Argyrios verfasserin aut Zheng, Wei verfasserin aut Yang, Hannah P. verfasserin aut Wu, Anna H. verfasserin aut Wozniak, Eva L. verfasserin aut Ling Woo, Yin verfasserin aut Winterhoff, Boris verfasserin aut Wik, Elisabeth verfasserin aut Whittemore, Alice S. verfasserin aut Wentzensen, Nicolas verfasserin aut Palmieri Weber, Rachel verfasserin aut Vitonis, Allison F. verfasserin aut Vincent, Daniel verfasserin aut Vierkant, Robert A. verfasserin aut Vergote, Ignace verfasserin aut Van Den Berg, David verfasserin aut Van Altena, Anne M. verfasserin aut Tworoger, Shelley S. verfasserin aut Thompson, Pamela J. verfasserin aut Tessier, Daniel C. verfasserin aut Terry, Kathryn L. verfasserin aut Teo, Soo-Hwang verfasserin aut Templeman, Claire verfasserin aut Stram, Daniel O. verfasserin aut Southey, Melissa C. verfasserin aut Sieh, Weiva verfasserin aut Siddiqui, Nadeem verfasserin aut Shvetsov, Yurii B. verfasserin aut Shu, Xiao-Ou verfasserin aut Shridhar, Viji verfasserin aut Wang-Gohrke, Shan verfasserin aut Severi, Gianluca verfasserin aut Schwaab, Ira verfasserin aut Salvesen, Helga B. verfasserin aut Rzepecka, Iwona K. verfasserin aut Runnebaum, Ingo B. verfasserin aut Anne Rossing, Mary verfasserin aut Rodriguez-Rodriguez, Lorna verfasserin aut Risch, Harvey A. verfasserin aut Renner, Stefan P. verfasserin aut Poole, Elizabeth M. verfasserin aut Pike, Malcolm C. verfasserin aut Phelan, Catherine M. verfasserin aut Pelttari, Liisa M. verfasserin aut Pejovic, Tanja verfasserin aut Paul, James verfasserin aut Orlow, Irene verfasserin aut Zawiah Omar, Siti verfasserin aut Olson, Sara H. verfasserin aut Odunsi, Kunle verfasserin aut Nickels, Stefan verfasserin aut Nevanlinna, Heli verfasserin aut Ness, Roberta B. verfasserin aut Narod, Steven A. verfasserin aut Nakanishi, Toru verfasserin aut Moysich, Kirsten B. verfasserin aut Monteiro, Alvaro N. A. verfasserin aut Moes-Sosnowska, Joanna verfasserin aut Modugno, Francesmary verfasserin aut Menon, Usha verfasserin aut McLaughlin, John R. verfasserin aut McGuire, Valerie verfasserin aut Matsuo, Keitaro verfasserin aut Mat Adenan, Noor Azmi verfasserin aut Massuger, Leon F. A. G. verfasserin aut Lurie, Galina verfasserin aut Lundvall, Lene verfasserin aut Lubiński, Jan verfasserin aut Lissowska, Jolanta verfasserin aut Levine, Douglas A. verfasserin aut Leminen, Arto verfasserin aut Lee, Alice W. verfasserin aut Le, Nhu D. verfasserin aut Lambrechts, Sandrina verfasserin aut Lambrechts, Diether verfasserin aut Kupryjanczyk, Jolanta verfasserin aut Krakstad, Camilla verfasserin aut Konecny, Gottfried E. verfasserin aut Krüger Kjaer, Susanne verfasserin aut Kiemeney, Lambertus A. verfasserin aut Kelemen, Linda E. verfasserin aut Keeney, Gary L. verfasserin aut Karlan, Beth Y. verfasserin aut Karevan, Rod verfasserin aut Kalli, Kimberly R. verfasserin aut Kajiyama, Hiroaki verfasserin aut Ji, Bu-Tian verfasserin aut Jensen, Allan verfasserin aut Jakubowska, Anna verfasserin aut Iversen, Edwin verfasserin aut Hosono, Satoyo verfasserin aut Høgdall, Claus K. verfasserin aut Høgdall, Estrid verfasserin aut Hoatlin, Maureen verfasserin aut Hillemanns, Peter verfasserin aut Heitz, Florian verfasserin aut Hein, Rebecca verfasserin aut Harter, Philipp verfasserin aut Halle, Mari K. verfasserin aut Hall, Per verfasserin aut Gronwald, Jacek verfasserin aut Gore, Martin verfasserin aut Goodman, Marc T. verfasserin aut Giles, Graham G. verfasserin aut Gentry-Maharaj, Aleksandra verfasserin aut Garcia-Closas, Montserrat verfasserin aut Flanagan, James M. verfasserin aut Fasching, Peter A. verfasserin aut Ekici, Arif B. verfasserin aut Edwards, Robert verfasserin aut Eccles, Diana verfasserin aut Easton, Douglas F. verfasserin aut Dürst, Matthias verfasserin aut du Bois, Andreas verfasserin aut Dörk, Thilo verfasserin aut Doherty, Jennifer A. verfasserin aut Despierre, Evelyn verfasserin aut Dansonka-Mieszkowska, Agnieszka verfasserin aut Cybulski, Cezary verfasserin aut Cramer, Daniel W. verfasserin aut Cook, Linda S. verfasserin aut Chen, Xiaoqing verfasserin aut Charbonneau, Bridget verfasserin aut Chang-Claude, Jenny verfasserin (DE-588)1049304993 (DE-627)781626188 (DE-576)168344475 aut Campbell, Ian verfasserin aut Butzow, Ralf verfasserin aut Bunker, Clareann H. verfasserin aut Brueggmann, Doerthe verfasserin aut Brown, Robert verfasserin aut Brooks-Wilson, Angela verfasserin aut Brinton, Louise A. verfasserin aut Bogdanova, Natalia verfasserin aut Block, Matthew S. verfasserin aut Benjamin, Elizabeth verfasserin aut Beesley, Jonathan verfasserin aut Beckmann, Matthias W. verfasserin aut Bandera, Elisa V. verfasserin aut Baglietto, Laura verfasserin aut Bacot, François verfasserin aut Armasu, Sebastian M. verfasserin aut Antonenkova, Natalia verfasserin aut Anton-Culver, Hoda verfasserin aut Aben, Katja K. verfasserin aut Liang, Dong verfasserin aut Wu, Xifeng verfasserin aut Lu, Karen verfasserin aut Hildebrandt, Michelle A. T. verfasserin aut Schildkraut, Joellen M. verfasserin aut Sellers, Thomas A. verfasserin aut Huntsman, David verfasserin aut Berchuck, Andrew verfasserin aut Chenevix-Trench, Georgia verfasserin aut Gayther, Simon A. verfasserin aut Pharoah, Paul D. P. verfasserin aut Laird, Peter W. verfasserin aut Goode, Ellen L. verfasserin aut Leigh Pearce, Celeste verfasserin aut Enthalten in Nature Communications [London] : Springer Nature, 2010 4(2013), Artikel-ID 1628, Seite 1-10 Online-Ressource (DE-627)626457688 (DE-600)2553671-0 (DE-576)331555905 2041-1723 nnns volume:4 year:2013 elocationid:1628 pages:1-10 extent:10 https://doi.org/10.1038/ncomms2629 Verlag Resolving-System lizenzpflichtig Volltext https://www.nature.com/articles/ncomms2629 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 1628 1-10 10 2013 01 DE-16-250 4042340857 00 --%%-- --%%-- --%%-- --%%-- l01 24-01-22 2013 01 DE-16-250 00 s hd2013 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_168 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1473283485 Chang-Claude, Jenny 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_135 |
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10.1038/ncomms2629 doi (DE-627)1787027686 (DE-599)KXP1787027686 (OCoLC)1341438994 DE-627 ger DE-627 rda eng Shen, Hui verfasserin (DE-588)1228750769 (DE-627)1750721686 aut Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer Hui Shen, Brooke L. Fridley, Honglin Song et al. 2013 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Published 27 March 2013 Gesehen am 24.01.2022 HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we comprehensively map variation in HNF1B with respect to epithelial ovarian cancer risk and analyse DNA methylation and expression profiles across histological subtypes. Different single-nucleotide polymorphisms associate with invasive serous (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10−10) and clear cell (rs11651755 OR=0.77, P=1.6 × 10−8) epithelial ovarian cancer. Risk alleles for the serous subtype associate with higher HNF1B-promoter methylation in these tumours. Unmethylated, expressed HNF1B, primarily present in clear cell tumours, coincides with a CpG island methylator phenotype affecting numerous other promoters throughout the genome. Different variants in HNF1B associate with risk of serous and clear cell epithelial ovarian cancer; DNA methylation and expression patterns are also notably distinct between these subtypes. These findings underscore distinct mechanisms driving different epithelial ovarian cancer histological subtypes. Cancer genetics Epigenetics analysis Ovarian cancer Fridley, Brooke L. verfasserin aut Song, Honglin verfasserin aut Lawrenson, Kate verfasserin aut Cunningham, Julie M. verfasserin aut Ramus, Susan J. verfasserin aut Cicek, Mine S. verfasserin aut Tyrer, Jonathan verfasserin aut Stram, Douglas verfasserin aut Larson, Melissa C. verfasserin aut Köbel, Martin verfasserin aut Ziogas, Argyrios verfasserin aut Zheng, Wei verfasserin aut Yang, Hannah P. verfasserin aut Wu, Anna H. verfasserin aut Wozniak, Eva L. verfasserin aut Ling Woo, Yin verfasserin aut Winterhoff, Boris verfasserin aut Wik, Elisabeth verfasserin aut Whittemore, Alice S. verfasserin aut Wentzensen, Nicolas verfasserin aut Palmieri Weber, Rachel verfasserin aut Vitonis, Allison F. verfasserin aut Vincent, Daniel verfasserin aut Vierkant, Robert A. verfasserin aut Vergote, Ignace verfasserin aut Van Den Berg, David verfasserin aut Van Altena, Anne M. verfasserin aut Tworoger, Shelley S. verfasserin aut Thompson, Pamela J. verfasserin aut Tessier, Daniel C. verfasserin aut Terry, Kathryn L. verfasserin aut Teo, Soo-Hwang verfasserin aut Templeman, Claire verfasserin aut Stram, Daniel O. verfasserin aut Southey, Melissa C. verfasserin aut Sieh, Weiva verfasserin aut Siddiqui, Nadeem verfasserin aut Shvetsov, Yurii B. verfasserin aut Shu, Xiao-Ou verfasserin aut Shridhar, Viji verfasserin aut Wang-Gohrke, Shan verfasserin aut Severi, Gianluca verfasserin aut Schwaab, Ira verfasserin aut Salvesen, Helga B. verfasserin aut Rzepecka, Iwona K. verfasserin aut Runnebaum, Ingo B. verfasserin aut Anne Rossing, Mary verfasserin aut Rodriguez-Rodriguez, Lorna verfasserin aut Risch, Harvey A. verfasserin aut Renner, Stefan P. verfasserin aut Poole, Elizabeth M. verfasserin aut Pike, Malcolm C. verfasserin aut Phelan, Catherine M. verfasserin aut Pelttari, Liisa M. verfasserin aut Pejovic, Tanja verfasserin aut Paul, James verfasserin aut Orlow, Irene verfasserin aut Zawiah Omar, Siti verfasserin aut Olson, Sara H. verfasserin aut Odunsi, Kunle verfasserin aut Nickels, Stefan verfasserin aut Nevanlinna, Heli verfasserin aut Ness, Roberta B. verfasserin aut Narod, Steven A. verfasserin aut Nakanishi, Toru verfasserin aut Moysich, Kirsten B. verfasserin aut Monteiro, Alvaro N. A. verfasserin aut Moes-Sosnowska, Joanna verfasserin aut Modugno, Francesmary verfasserin aut Menon, Usha verfasserin aut McLaughlin, John R. verfasserin aut McGuire, Valerie verfasserin aut Matsuo, Keitaro verfasserin aut Mat Adenan, Noor Azmi verfasserin aut Massuger, Leon F. A. G. verfasserin aut Lurie, Galina verfasserin aut Lundvall, Lene verfasserin aut Lubiński, Jan verfasserin aut Lissowska, Jolanta verfasserin aut Levine, Douglas A. verfasserin aut Leminen, Arto verfasserin aut Lee, Alice W. verfasserin aut Le, Nhu D. verfasserin aut Lambrechts, Sandrina verfasserin aut Lambrechts, Diether verfasserin aut Kupryjanczyk, Jolanta verfasserin aut Krakstad, Camilla verfasserin aut Konecny, Gottfried E. verfasserin aut Krüger Kjaer, Susanne verfasserin aut Kiemeney, Lambertus A. verfasserin aut Kelemen, Linda E. verfasserin aut Keeney, Gary L. verfasserin aut Karlan, Beth Y. verfasserin aut Karevan, Rod verfasserin aut Kalli, Kimberly R. verfasserin aut Kajiyama, Hiroaki verfasserin aut Ji, Bu-Tian verfasserin aut Jensen, Allan verfasserin aut Jakubowska, Anna verfasserin aut Iversen, Edwin verfasserin aut Hosono, Satoyo verfasserin aut Høgdall, Claus K. verfasserin aut Høgdall, Estrid verfasserin aut Hoatlin, Maureen verfasserin aut Hillemanns, Peter verfasserin aut Heitz, Florian verfasserin aut Hein, Rebecca verfasserin aut Harter, Philipp verfasserin aut Halle, Mari K. verfasserin aut Hall, Per verfasserin aut Gronwald, Jacek verfasserin aut Gore, Martin verfasserin aut Goodman, Marc T. verfasserin aut Giles, Graham G. verfasserin aut Gentry-Maharaj, Aleksandra verfasserin aut Garcia-Closas, Montserrat verfasserin aut Flanagan, James M. verfasserin aut Fasching, Peter A. verfasserin aut Ekici, Arif B. verfasserin aut Edwards, Robert verfasserin aut Eccles, Diana verfasserin aut Easton, Douglas F. verfasserin aut Dürst, Matthias verfasserin aut du Bois, Andreas verfasserin aut Dörk, Thilo verfasserin aut Doherty, Jennifer A. verfasserin aut Despierre, Evelyn verfasserin aut Dansonka-Mieszkowska, Agnieszka verfasserin aut Cybulski, Cezary verfasserin aut Cramer, Daniel W. verfasserin aut Cook, Linda S. verfasserin aut Chen, Xiaoqing verfasserin aut Charbonneau, Bridget verfasserin aut Chang-Claude, Jenny verfasserin (DE-588)1049304993 (DE-627)781626188 (DE-576)168344475 aut Campbell, Ian verfasserin aut Butzow, Ralf verfasserin aut Bunker, Clareann H. verfasserin aut Brueggmann, Doerthe verfasserin aut Brown, Robert verfasserin aut Brooks-Wilson, Angela verfasserin aut Brinton, Louise A. verfasserin aut Bogdanova, Natalia verfasserin aut Block, Matthew S. verfasserin aut Benjamin, Elizabeth verfasserin aut Beesley, Jonathan verfasserin aut Beckmann, Matthias W. verfasserin aut Bandera, Elisa V. verfasserin aut Baglietto, Laura verfasserin aut Bacot, François verfasserin aut Armasu, Sebastian M. verfasserin aut Antonenkova, Natalia verfasserin aut Anton-Culver, Hoda verfasserin aut Aben, Katja K. verfasserin aut Liang, Dong verfasserin aut Wu, Xifeng verfasserin aut Lu, Karen verfasserin aut Hildebrandt, Michelle A. T. verfasserin aut Schildkraut, Joellen M. verfasserin aut Sellers, Thomas A. verfasserin aut Huntsman, David verfasserin aut Berchuck, Andrew verfasserin aut Chenevix-Trench, Georgia verfasserin aut Gayther, Simon A. verfasserin aut Pharoah, Paul D. P. verfasserin aut Laird, Peter W. verfasserin aut Goode, Ellen L. verfasserin aut Leigh Pearce, Celeste verfasserin aut Enthalten in Nature Communications [London] : Springer Nature, 2010 4(2013), Artikel-ID 1628, Seite 1-10 Online-Ressource (DE-627)626457688 (DE-600)2553671-0 (DE-576)331555905 2041-1723 nnns volume:4 year:2013 elocationid:1628 pages:1-10 extent:10 https://doi.org/10.1038/ncomms2629 Verlag Resolving-System lizenzpflichtig Volltext https://www.nature.com/articles/ncomms2629 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 1628 1-10 10 2013 01 DE-16-250 4042340857 00 --%%-- --%%-- --%%-- --%%-- l01 24-01-22 2013 01 DE-16-250 00 s hd2013 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_168 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1473283485 Chang-Claude, Jenny 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_135 |
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10.1038/ncomms2629 doi (DE-627)1787027686 (DE-599)KXP1787027686 (OCoLC)1341438994 DE-627 ger DE-627 rda eng Shen, Hui verfasserin (DE-588)1228750769 (DE-627)1750721686 aut Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer Hui Shen, Brooke L. Fridley, Honglin Song et al. 2013 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Published 27 March 2013 Gesehen am 24.01.2022 HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we comprehensively map variation in HNF1B with respect to epithelial ovarian cancer risk and analyse DNA methylation and expression profiles across histological subtypes. Different single-nucleotide polymorphisms associate with invasive serous (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10−10) and clear cell (rs11651755 OR=0.77, P=1.6 × 10−8) epithelial ovarian cancer. Risk alleles for the serous subtype associate with higher HNF1B-promoter methylation in these tumours. Unmethylated, expressed HNF1B, primarily present in clear cell tumours, coincides with a CpG island methylator phenotype affecting numerous other promoters throughout the genome. Different variants in HNF1B associate with risk of serous and clear cell epithelial ovarian cancer; DNA methylation and expression patterns are also notably distinct between these subtypes. These findings underscore distinct mechanisms driving different epithelial ovarian cancer histological subtypes. Cancer genetics Epigenetics analysis Ovarian cancer Fridley, Brooke L. verfasserin aut Song, Honglin verfasserin aut Lawrenson, Kate verfasserin aut Cunningham, Julie M. verfasserin aut Ramus, Susan J. verfasserin aut Cicek, Mine S. verfasserin aut Tyrer, Jonathan verfasserin aut Stram, Douglas verfasserin aut Larson, Melissa C. verfasserin aut Köbel, Martin verfasserin aut Ziogas, Argyrios verfasserin aut Zheng, Wei verfasserin aut Yang, Hannah P. verfasserin aut Wu, Anna H. verfasserin aut Wozniak, Eva L. verfasserin aut Ling Woo, Yin verfasserin aut Winterhoff, Boris verfasserin aut Wik, Elisabeth verfasserin aut Whittemore, Alice S. verfasserin aut Wentzensen, Nicolas verfasserin aut Palmieri Weber, Rachel verfasserin aut Vitonis, Allison F. verfasserin aut Vincent, Daniel verfasserin aut Vierkant, Robert A. verfasserin aut Vergote, Ignace verfasserin aut Van Den Berg, David verfasserin aut Van Altena, Anne M. verfasserin aut Tworoger, Shelley S. verfasserin aut Thompson, Pamela J. verfasserin aut Tessier, Daniel C. verfasserin aut Terry, Kathryn L. verfasserin aut Teo, Soo-Hwang verfasserin aut Templeman, Claire verfasserin aut Stram, Daniel O. verfasserin aut Southey, Melissa C. verfasserin aut Sieh, Weiva verfasserin aut Siddiqui, Nadeem verfasserin aut Shvetsov, Yurii B. verfasserin aut Shu, Xiao-Ou verfasserin aut Shridhar, Viji verfasserin aut Wang-Gohrke, Shan verfasserin aut Severi, Gianluca verfasserin aut Schwaab, Ira verfasserin aut Salvesen, Helga B. verfasserin aut Rzepecka, Iwona K. verfasserin aut Runnebaum, Ingo B. verfasserin aut Anne Rossing, Mary verfasserin aut Rodriguez-Rodriguez, Lorna verfasserin aut Risch, Harvey A. verfasserin aut Renner, Stefan P. verfasserin aut Poole, Elizabeth M. verfasserin aut Pike, Malcolm C. verfasserin aut Phelan, Catherine M. verfasserin aut Pelttari, Liisa M. verfasserin aut Pejovic, Tanja verfasserin aut Paul, James verfasserin aut Orlow, Irene verfasserin aut Zawiah Omar, Siti verfasserin aut Olson, Sara H. verfasserin aut Odunsi, Kunle verfasserin aut Nickels, Stefan verfasserin aut Nevanlinna, Heli verfasserin aut Ness, Roberta B. verfasserin aut Narod, Steven A. verfasserin aut Nakanishi, Toru verfasserin aut Moysich, Kirsten B. verfasserin aut Monteiro, Alvaro N. A. verfasserin aut Moes-Sosnowska, Joanna verfasserin aut Modugno, Francesmary verfasserin aut Menon, Usha verfasserin aut McLaughlin, John R. verfasserin aut McGuire, Valerie verfasserin aut Matsuo, Keitaro verfasserin aut Mat Adenan, Noor Azmi verfasserin aut Massuger, Leon F. A. G. verfasserin aut Lurie, Galina verfasserin aut Lundvall, Lene verfasserin aut Lubiński, Jan verfasserin aut Lissowska, Jolanta verfasserin aut Levine, Douglas A. verfasserin aut Leminen, Arto verfasserin aut Lee, Alice W. verfasserin aut Le, Nhu D. verfasserin aut Lambrechts, Sandrina verfasserin aut Lambrechts, Diether verfasserin aut Kupryjanczyk, Jolanta verfasserin aut Krakstad, Camilla verfasserin aut Konecny, Gottfried E. verfasserin aut Krüger Kjaer, Susanne verfasserin aut Kiemeney, Lambertus A. verfasserin aut Kelemen, Linda E. verfasserin aut Keeney, Gary L. verfasserin aut Karlan, Beth Y. verfasserin aut Karevan, Rod verfasserin aut Kalli, Kimberly R. verfasserin aut Kajiyama, Hiroaki verfasserin aut Ji, Bu-Tian verfasserin aut Jensen, Allan verfasserin aut Jakubowska, Anna verfasserin aut Iversen, Edwin verfasserin aut Hosono, Satoyo verfasserin aut Høgdall, Claus K. verfasserin aut Høgdall, Estrid verfasserin aut Hoatlin, Maureen verfasserin aut Hillemanns, Peter verfasserin aut Heitz, Florian verfasserin aut Hein, Rebecca verfasserin aut Harter, Philipp verfasserin aut Halle, Mari K. verfasserin aut Hall, Per verfasserin aut Gronwald, Jacek verfasserin aut Gore, Martin verfasserin aut Goodman, Marc T. verfasserin aut Giles, Graham G. verfasserin aut Gentry-Maharaj, Aleksandra verfasserin aut Garcia-Closas, Montserrat verfasserin aut Flanagan, James M. verfasserin aut Fasching, Peter A. verfasserin aut Ekici, Arif B. verfasserin aut Edwards, Robert verfasserin aut Eccles, Diana verfasserin aut Easton, Douglas F. verfasserin aut Dürst, Matthias verfasserin aut du Bois, Andreas verfasserin aut Dörk, Thilo verfasserin aut Doherty, Jennifer A. verfasserin aut Despierre, Evelyn verfasserin aut Dansonka-Mieszkowska, Agnieszka verfasserin aut Cybulski, Cezary verfasserin aut Cramer, Daniel W. verfasserin aut Cook, Linda S. verfasserin aut Chen, Xiaoqing verfasserin aut Charbonneau, Bridget verfasserin aut Chang-Claude, Jenny verfasserin (DE-588)1049304993 (DE-627)781626188 (DE-576)168344475 aut Campbell, Ian verfasserin aut Butzow, Ralf verfasserin aut Bunker, Clareann H. verfasserin aut Brueggmann, Doerthe verfasserin aut Brown, Robert verfasserin aut Brooks-Wilson, Angela verfasserin aut Brinton, Louise A. verfasserin aut Bogdanova, Natalia verfasserin aut Block, Matthew S. verfasserin aut Benjamin, Elizabeth verfasserin aut Beesley, Jonathan verfasserin aut Beckmann, Matthias W. verfasserin aut Bandera, Elisa V. verfasserin aut Baglietto, Laura verfasserin aut Bacot, François verfasserin aut Armasu, Sebastian M. verfasserin aut Antonenkova, Natalia verfasserin aut Anton-Culver, Hoda verfasserin aut Aben, Katja K. verfasserin aut Liang, Dong verfasserin aut Wu, Xifeng verfasserin aut Lu, Karen verfasserin aut Hildebrandt, Michelle A. T. verfasserin aut Schildkraut, Joellen M. verfasserin aut Sellers, Thomas A. verfasserin aut Huntsman, David verfasserin aut Berchuck, Andrew verfasserin aut Chenevix-Trench, Georgia verfasserin aut Gayther, Simon A. verfasserin aut Pharoah, Paul D. P. verfasserin aut Laird, Peter W. verfasserin aut Goode, Ellen L. verfasserin aut Leigh Pearce, Celeste verfasserin aut Enthalten in Nature Communications [London] : Springer Nature, 2010 4(2013), Artikel-ID 1628, Seite 1-10 Online-Ressource (DE-627)626457688 (DE-600)2553671-0 (DE-576)331555905 2041-1723 nnns volume:4 year:2013 elocationid:1628 pages:1-10 extent:10 https://doi.org/10.1038/ncomms2629 Verlag Resolving-System lizenzpflichtig Volltext https://www.nature.com/articles/ncomms2629 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 1628 1-10 10 2013 01 DE-16-250 4042340857 00 --%%-- --%%-- --%%-- --%%-- l01 24-01-22 2013 01 DE-16-250 00 s hd2013 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_168 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1473283485 Chang-Claude, Jenny 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_135 |
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epigenetic analysis leads to identification of hnf1b as a subtype-specific susceptibility gene for ovarian cancer |
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Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer |
| abstract |
HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we comprehensively map variation in HNF1B with respect to epithelial ovarian cancer risk and analyse DNA methylation and expression profiles across histological subtypes. Different single-nucleotide polymorphisms associate with invasive serous (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10−10) and clear cell (rs11651755 OR=0.77, P=1.6 × 10−8) epithelial ovarian cancer. Risk alleles for the serous subtype associate with higher HNF1B-promoter methylation in these tumours. Unmethylated, expressed HNF1B, primarily present in clear cell tumours, coincides with a CpG island methylator phenotype affecting numerous other promoters throughout the genome. Different variants in HNF1B associate with risk of serous and clear cell epithelial ovarian cancer; DNA methylation and expression patterns are also notably distinct between these subtypes. These findings underscore distinct mechanisms driving different epithelial ovarian cancer histological subtypes. Published 27 March 2013 Gesehen am 24.01.2022 |
| abstractGer |
HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we comprehensively map variation in HNF1B with respect to epithelial ovarian cancer risk and analyse DNA methylation and expression profiles across histological subtypes. Different single-nucleotide polymorphisms associate with invasive serous (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10−10) and clear cell (rs11651755 OR=0.77, P=1.6 × 10−8) epithelial ovarian cancer. Risk alleles for the serous subtype associate with higher HNF1B-promoter methylation in these tumours. Unmethylated, expressed HNF1B, primarily present in clear cell tumours, coincides with a CpG island methylator phenotype affecting numerous other promoters throughout the genome. Different variants in HNF1B associate with risk of serous and clear cell epithelial ovarian cancer; DNA methylation and expression patterns are also notably distinct between these subtypes. These findings underscore distinct mechanisms driving different epithelial ovarian cancer histological subtypes. Published 27 March 2013 Gesehen am 24.01.2022 |
| abstract_unstemmed |
HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we comprehensively map variation in HNF1B with respect to epithelial ovarian cancer risk and analyse DNA methylation and expression profiles across histological subtypes. Different single-nucleotide polymorphisms associate with invasive serous (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10−10) and clear cell (rs11651755 OR=0.77, P=1.6 × 10−8) epithelial ovarian cancer. Risk alleles for the serous subtype associate with higher HNF1B-promoter methylation in these tumours. Unmethylated, expressed HNF1B, primarily present in clear cell tumours, coincides with a CpG island methylator phenotype affecting numerous other promoters throughout the genome. Different variants in HNF1B associate with risk of serous and clear cell epithelial ovarian cancer; DNA methylation and expression patterns are also notably distinct between these subtypes. These findings underscore distinct mechanisms driving different epithelial ovarian cancer histological subtypes. Published 27 March 2013 Gesehen am 24.01.2022 |
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Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer |
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https://doi.org/10.1038/ncomms2629 https://www.nature.com/articles/ncomms2629 |
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