Novel associations between inflammation-related proteins and adiposity : a targeted proteomics approach across four population-based studies
Chronic low-grade inflammation has been proposed as a linking mechanism between obesity and the development of inflammation-related conditions such as insulin resistance and cardiovascular disease. Despite major advances in the last 2 decades, the complex relationship between inflammation and obesit...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ponce-de-Leon, Mariana [verfasserIn] Linseisen, Jakob [verfasserIn] Peters, Annette [verfasserIn] Linkohr, Birgit [verfasserIn] Heier, Margit [verfasserIn] Grallert, Harald [verfasserIn] Schöttker, Ben [verfasserIn] Trares, Kira - 1994- [verfasserIn] Bhardwaj, Megha - 1985- [verfasserIn] Gao, Xin - 1989- [verfasserIn] Brenner, Hermann [verfasserIn] Kamiński, Karol Adam [verfasserIn] Paniczko, Marlena [verfasserIn] Kowalska, Irina [verfasserIn] Baumeister, Sebastian-Edgar [verfasserIn] Meisinger, Christa [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Anmerkung: |
Gesehen am 25.05.2022 First published online: 12 November 2021 |
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| Umfang: |
12 |
| Übergeordnetes Werk: |
Enthalten in: Translational research - New York, NY : Elsevier, 2006, 242(2022) vom: Apr., Seite 93-104 |
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| Übergeordnetes Werk: |
volume:242 ; year:2022 ; month:04 ; pages:93-104 ; extent:12 |
| Links: |
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| DOI / URN: |
10.1016/j.trsl.2021.11.004 |
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| Katalog-ID: |
180438710X |
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| 245 | 1 | 0 | |a Novel associations between inflammation-related proteins and adiposity |b a targeted proteomics approach across four population-based studies |c Mariana Ponce-de-Leon, Jakob Linseisen, Annette Peters, Birgit Linkohr, Margit Heier, Harald Grallert, Ben Schöttker, Kira Trares, Megha Bhardwaj, Xīn Gào, Herman Brenner, Karol Adam Kamiński, Marlena Paniczko, Irina Kowalska, Sebastian-Edgar Baumeister, and Christa Meisinger |
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| 520 | |a Chronic low-grade inflammation has been proposed as a linking mechanism between obesity and the development of inflammation-related conditions such as insulin resistance and cardiovascular disease. Despite major advances in the last 2 decades, the complex relationship between inflammation and obesity remains poorly understood. Therefore, we aimed to identify novel inflammation-related proteins associated with adiposity. We investigated the association between BMI and waist circumference and 72 circulating inflammation-related proteins, measured using the Proximity Extension Assay (Olink Proteomics), in 3,308 participants of four independent European population-based studies (KORA-Fit, BVSII, ESTHER, and Bialystok PLUS). In addition, we used body fat mass measurements obtained by Dual-energy X-ray absorptiometry (DXA) in the Bialystok PLUS study to further validate our results and to explore the relationship between inflammation-related proteins and body fat distribution. We found 14 proteins associated with at least one measure of adiposity across all four studies, including four proteins for which the association is novel: DNER, SLAMF1, RANKL, and CSF-1. We confirmed previously reported associations with CCL19, CCL28, FGF-21, HGF, IL-10RB, IL-18, IL-18R1, IL-6, SCF, and VEGF-A. The majority of the identified inflammation-related proteins were associated with visceral fat as well as with the accumulation of adipose tissue in the abdomen and the trunk. In conclusion, our study provides new insights into the immune dysregulation observed in obesity that might help uncover pathophysiological mechanisms of disease development. | ||
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10.1016/j.trsl.2021.11.004 doi (DE-627)180438710X (DE-599)KXP180438710X (OCoLC)1341460367 DE-627 ger DE-627 rda eng Ponce-de-Leon, Mariana verfasserin (DE-588)1258407434 (DE-627)1804388548 aut Novel associations between inflammation-related proteins and adiposity a targeted proteomics approach across four population-based studies Mariana Ponce-de-Leon, Jakob Linseisen, Annette Peters, Birgit Linkohr, Margit Heier, Harald Grallert, Ben Schöttker, Kira Trares, Megha Bhardwaj, Xīn Gào, Herman Brenner, Karol Adam Kamiński, Marlena Paniczko, Irina Kowalska, Sebastian-Edgar Baumeister, and Christa Meisinger 2022 12 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 25.05.2022 First published online: 12 November 2021 Chronic low-grade inflammation has been proposed as a linking mechanism between obesity and the development of inflammation-related conditions such as insulin resistance and cardiovascular disease. Despite major advances in the last 2 decades, the complex relationship between inflammation and obesity remains poorly understood. Therefore, we aimed to identify novel inflammation-related proteins associated with adiposity. We investigated the association between BMI and waist circumference and 72 circulating inflammation-related proteins, measured using the Proximity Extension Assay (Olink Proteomics), in 3,308 participants of four independent European population-based studies (KORA-Fit, BVSII, ESTHER, and Bialystok PLUS). In addition, we used body fat mass measurements obtained by Dual-energy X-ray absorptiometry (DXA) in the Bialystok PLUS study to further validate our results and to explore the relationship between inflammation-related proteins and body fat distribution. We found 14 proteins associated with at least one measure of adiposity across all four studies, including four proteins for which the association is novel: DNER, SLAMF1, RANKL, and CSF-1. We confirmed previously reported associations with CCL19, CCL28, FGF-21, HGF, IL-10RB, IL-18, IL-18R1, IL-6, SCF, and VEGF-A. The majority of the identified inflammation-related proteins were associated with visceral fat as well as with the accumulation of adipose tissue in the abdomen and the trunk. In conclusion, our study provides new insights into the immune dysregulation observed in obesity that might help uncover pathophysiological mechanisms of disease development. Linseisen, Jakob verfasserin aut Peters, Annette verfasserin aut Linkohr, Birgit verfasserin aut Heier, Margit verfasserin aut Grallert, Harald verfasserin aut Schöttker, Ben verfasserin (DE-588)138862443 (DE-627)703132423 (DE-576)309375657 aut Trares, Kira 1994- verfasserin (DE-588)1221159763 (DE-627)1738319326 aut Bhardwaj, Megha 1985- verfasserin (DE-588)1147332606 (DE-627)1006074554 (DE-576)495748021 aut Gao, Xin 1989- verfasserin (DE-588)1161229086 (DE-627)1024634108 (DE-576)506422666 aut Brenner, Hermann verfasserin (DE-588)1020516445 (DE-627)691247005 (DE-576)360642136 aut Kamiński, Karol Adam verfasserin aut Paniczko, Marlena verfasserin aut Kowalska, Irina verfasserin aut Baumeister, Sebastian-Edgar verfasserin aut Meisinger, Christa verfasserin aut Enthalten in Translational research New York, NY : Elsevier, 2006 242(2022) vom: Apr., Seite 93-104 Online-Ressource (DE-627)51810365X (DE-600)2252085-5 (DE-576)261041029 1878-1810 nnns volume:242 year:2022 month:04 pages:93-104 extent:12 https://doi.org/10.1016/j.trsl.2021.11.004 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S193152442100267X Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 242 2022 4 93-104 12 2013 01 DE-16-250 413960588X 00 --%%-- --%%-- --%%-- --%%-- l01 25-05-22 2013 01 DE-16-250 00 s hd2022 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_16 2013 01 DE-16-250 03 s s_12 2013 01 DE-16-250 04 p (DE-627)1524451177 Schöttker, Ben 2013 01 DE-16-250 04 k (DE-627)143134298X Netzwerk AlternsfoRschung (NAR) 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_7 2013 01 DE-16-250 05 p (DE-627)1738319687 Trares, Kira 2013 01 DE-16-250 05 k (DE-627)143134298X Netzwerk AlternsfoRschung (NAR) 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_8 2013 01 DE-16-250 06 p (DE-627)1694602990 Bhardwaj, Megha 2013 01 DE-16-250 06 k (DE-627)1416822720 Extern 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_9 2013 01 DE-16-250 07 p (DE-627)157650316X Gao, Xin 2013 01 DE-16-250 07 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_10 2013 01 DE-16-250 08 p (DE-627)1430642343 Brenner, Hermann 2013 01 DE-16-250 08 k (DE-627)143134298X Netzwerk AlternsfoRschung (NAR) 2013 01 DE-16-250 08 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_11 |
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10.1016/j.trsl.2021.11.004 doi (DE-627)180438710X (DE-599)KXP180438710X (OCoLC)1341460367 DE-627 ger DE-627 rda eng Ponce-de-Leon, Mariana verfasserin (DE-588)1258407434 (DE-627)1804388548 aut Novel associations between inflammation-related proteins and adiposity a targeted proteomics approach across four population-based studies Mariana Ponce-de-Leon, Jakob Linseisen, Annette Peters, Birgit Linkohr, Margit Heier, Harald Grallert, Ben Schöttker, Kira Trares, Megha Bhardwaj, Xīn Gào, Herman Brenner, Karol Adam Kamiński, Marlena Paniczko, Irina Kowalska, Sebastian-Edgar Baumeister, and Christa Meisinger 2022 12 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 25.05.2022 First published online: 12 November 2021 Chronic low-grade inflammation has been proposed as a linking mechanism between obesity and the development of inflammation-related conditions such as insulin resistance and cardiovascular disease. Despite major advances in the last 2 decades, the complex relationship between inflammation and obesity remains poorly understood. Therefore, we aimed to identify novel inflammation-related proteins associated with adiposity. We investigated the association between BMI and waist circumference and 72 circulating inflammation-related proteins, measured using the Proximity Extension Assay (Olink Proteomics), in 3,308 participants of four independent European population-based studies (KORA-Fit, BVSII, ESTHER, and Bialystok PLUS). In addition, we used body fat mass measurements obtained by Dual-energy X-ray absorptiometry (DXA) in the Bialystok PLUS study to further validate our results and to explore the relationship between inflammation-related proteins and body fat distribution. We found 14 proteins associated with at least one measure of adiposity across all four studies, including four proteins for which the association is novel: DNER, SLAMF1, RANKL, and CSF-1. We confirmed previously reported associations with CCL19, CCL28, FGF-21, HGF, IL-10RB, IL-18, IL-18R1, IL-6, SCF, and VEGF-A. The majority of the identified inflammation-related proteins were associated with visceral fat as well as with the accumulation of adipose tissue in the abdomen and the trunk. In conclusion, our study provides new insights into the immune dysregulation observed in obesity that might help uncover pathophysiological mechanisms of disease development. Linseisen, Jakob verfasserin aut Peters, Annette verfasserin aut Linkohr, Birgit verfasserin aut Heier, Margit verfasserin aut Grallert, Harald verfasserin aut Schöttker, Ben verfasserin (DE-588)138862443 (DE-627)703132423 (DE-576)309375657 aut Trares, Kira 1994- verfasserin (DE-588)1221159763 (DE-627)1738319326 aut Bhardwaj, Megha 1985- verfasserin (DE-588)1147332606 (DE-627)1006074554 (DE-576)495748021 aut Gao, Xin 1989- verfasserin (DE-588)1161229086 (DE-627)1024634108 (DE-576)506422666 aut Brenner, Hermann verfasserin (DE-588)1020516445 (DE-627)691247005 (DE-576)360642136 aut Kamiński, Karol Adam verfasserin aut Paniczko, Marlena verfasserin aut Kowalska, Irina verfasserin aut Baumeister, Sebastian-Edgar verfasserin aut Meisinger, Christa verfasserin aut Enthalten in Translational research New York, NY : Elsevier, 2006 242(2022) vom: Apr., Seite 93-104 Online-Ressource (DE-627)51810365X (DE-600)2252085-5 (DE-576)261041029 1878-1810 nnns volume:242 year:2022 month:04 pages:93-104 extent:12 https://doi.org/10.1016/j.trsl.2021.11.004 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S193152442100267X Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 242 2022 4 93-104 12 2013 01 DE-16-250 413960588X 00 --%%-- --%%-- --%%-- --%%-- l01 25-05-22 2013 01 DE-16-250 00 s hd2022 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_16 2013 01 DE-16-250 03 s s_12 2013 01 DE-16-250 04 p (DE-627)1524451177 Schöttker, Ben 2013 01 DE-16-250 04 k (DE-627)143134298X Netzwerk AlternsfoRschung (NAR) 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_7 2013 01 DE-16-250 05 p (DE-627)1738319687 Trares, Kira 2013 01 DE-16-250 05 k (DE-627)143134298X Netzwerk AlternsfoRschung (NAR) 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_8 2013 01 DE-16-250 06 p (DE-627)1694602990 Bhardwaj, Megha 2013 01 DE-16-250 06 k (DE-627)1416822720 Extern 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_9 2013 01 DE-16-250 07 p (DE-627)157650316X Gao, Xin 2013 01 DE-16-250 07 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_10 2013 01 DE-16-250 08 p (DE-627)1430642343 Brenner, Hermann 2013 01 DE-16-250 08 k (DE-627)143134298X Netzwerk AlternsfoRschung (NAR) 2013 01 DE-16-250 08 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_11 |
| allfields_unstemmed |
10.1016/j.trsl.2021.11.004 doi (DE-627)180438710X (DE-599)KXP180438710X (OCoLC)1341460367 DE-627 ger DE-627 rda eng Ponce-de-Leon, Mariana verfasserin (DE-588)1258407434 (DE-627)1804388548 aut Novel associations between inflammation-related proteins and adiposity a targeted proteomics approach across four population-based studies Mariana Ponce-de-Leon, Jakob Linseisen, Annette Peters, Birgit Linkohr, Margit Heier, Harald Grallert, Ben Schöttker, Kira Trares, Megha Bhardwaj, Xīn Gào, Herman Brenner, Karol Adam Kamiński, Marlena Paniczko, Irina Kowalska, Sebastian-Edgar Baumeister, and Christa Meisinger 2022 12 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 25.05.2022 First published online: 12 November 2021 Chronic low-grade inflammation has been proposed as a linking mechanism between obesity and the development of inflammation-related conditions such as insulin resistance and cardiovascular disease. Despite major advances in the last 2 decades, the complex relationship between inflammation and obesity remains poorly understood. Therefore, we aimed to identify novel inflammation-related proteins associated with adiposity. We investigated the association between BMI and waist circumference and 72 circulating inflammation-related proteins, measured using the Proximity Extension Assay (Olink Proteomics), in 3,308 participants of four independent European population-based studies (KORA-Fit, BVSII, ESTHER, and Bialystok PLUS). In addition, we used body fat mass measurements obtained by Dual-energy X-ray absorptiometry (DXA) in the Bialystok PLUS study to further validate our results and to explore the relationship between inflammation-related proteins and body fat distribution. We found 14 proteins associated with at least one measure of adiposity across all four studies, including four proteins for which the association is novel: DNER, SLAMF1, RANKL, and CSF-1. We confirmed previously reported associations with CCL19, CCL28, FGF-21, HGF, IL-10RB, IL-18, IL-18R1, IL-6, SCF, and VEGF-A. The majority of the identified inflammation-related proteins were associated with visceral fat as well as with the accumulation of adipose tissue in the abdomen and the trunk. In conclusion, our study provides new insights into the immune dysregulation observed in obesity that might help uncover pathophysiological mechanisms of disease development. Linseisen, Jakob verfasserin aut Peters, Annette verfasserin aut Linkohr, Birgit verfasserin aut Heier, Margit verfasserin aut Grallert, Harald verfasserin aut Schöttker, Ben verfasserin (DE-588)138862443 (DE-627)703132423 (DE-576)309375657 aut Trares, Kira 1994- verfasserin (DE-588)1221159763 (DE-627)1738319326 aut Bhardwaj, Megha 1985- verfasserin (DE-588)1147332606 (DE-627)1006074554 (DE-576)495748021 aut Gao, Xin 1989- verfasserin (DE-588)1161229086 (DE-627)1024634108 (DE-576)506422666 aut Brenner, Hermann verfasserin (DE-588)1020516445 (DE-627)691247005 (DE-576)360642136 aut Kamiński, Karol Adam verfasserin aut Paniczko, Marlena verfasserin aut Kowalska, Irina verfasserin aut Baumeister, Sebastian-Edgar verfasserin aut Meisinger, Christa verfasserin aut Enthalten in Translational research New York, NY : Elsevier, 2006 242(2022) vom: Apr., Seite 93-104 Online-Ressource (DE-627)51810365X (DE-600)2252085-5 (DE-576)261041029 1878-1810 nnns volume:242 year:2022 month:04 pages:93-104 extent:12 https://doi.org/10.1016/j.trsl.2021.11.004 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S193152442100267X Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 242 2022 4 93-104 12 2013 01 DE-16-250 413960588X 00 --%%-- --%%-- --%%-- --%%-- l01 25-05-22 2013 01 DE-16-250 00 s hd2022 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_16 2013 01 DE-16-250 03 s s_12 2013 01 DE-16-250 04 p (DE-627)1524451177 Schöttker, Ben 2013 01 DE-16-250 04 k (DE-627)143134298X Netzwerk AlternsfoRschung (NAR) 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_7 2013 01 DE-16-250 05 p (DE-627)1738319687 Trares, Kira 2013 01 DE-16-250 05 k (DE-627)143134298X Netzwerk AlternsfoRschung (NAR) 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_8 2013 01 DE-16-250 06 p (DE-627)1694602990 Bhardwaj, Megha 2013 01 DE-16-250 06 k (DE-627)1416822720 Extern 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_9 2013 01 DE-16-250 07 p (DE-627)157650316X Gao, Xin 2013 01 DE-16-250 07 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_10 2013 01 DE-16-250 08 p (DE-627)1430642343 Brenner, Hermann 2013 01 DE-16-250 08 k (DE-627)143134298X Netzwerk AlternsfoRschung (NAR) 2013 01 DE-16-250 08 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_11 |
| allfieldsGer |
10.1016/j.trsl.2021.11.004 doi (DE-627)180438710X (DE-599)KXP180438710X (OCoLC)1341460367 DE-627 ger DE-627 rda eng Ponce-de-Leon, Mariana verfasserin (DE-588)1258407434 (DE-627)1804388548 aut Novel associations between inflammation-related proteins and adiposity a targeted proteomics approach across four population-based studies Mariana Ponce-de-Leon, Jakob Linseisen, Annette Peters, Birgit Linkohr, Margit Heier, Harald Grallert, Ben Schöttker, Kira Trares, Megha Bhardwaj, Xīn Gào, Herman Brenner, Karol Adam Kamiński, Marlena Paniczko, Irina Kowalska, Sebastian-Edgar Baumeister, and Christa Meisinger 2022 12 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 25.05.2022 First published online: 12 November 2021 Chronic low-grade inflammation has been proposed as a linking mechanism between obesity and the development of inflammation-related conditions such as insulin resistance and cardiovascular disease. Despite major advances in the last 2 decades, the complex relationship between inflammation and obesity remains poorly understood. Therefore, we aimed to identify novel inflammation-related proteins associated with adiposity. We investigated the association between BMI and waist circumference and 72 circulating inflammation-related proteins, measured using the Proximity Extension Assay (Olink Proteomics), in 3,308 participants of four independent European population-based studies (KORA-Fit, BVSII, ESTHER, and Bialystok PLUS). In addition, we used body fat mass measurements obtained by Dual-energy X-ray absorptiometry (DXA) in the Bialystok PLUS study to further validate our results and to explore the relationship between inflammation-related proteins and body fat distribution. We found 14 proteins associated with at least one measure of adiposity across all four studies, including four proteins for which the association is novel: DNER, SLAMF1, RANKL, and CSF-1. We confirmed previously reported associations with CCL19, CCL28, FGF-21, HGF, IL-10RB, IL-18, IL-18R1, IL-6, SCF, and VEGF-A. The majority of the identified inflammation-related proteins were associated with visceral fat as well as with the accumulation of adipose tissue in the abdomen and the trunk. In conclusion, our study provides new insights into the immune dysregulation observed in obesity that might help uncover pathophysiological mechanisms of disease development. Linseisen, Jakob verfasserin aut Peters, Annette verfasserin aut Linkohr, Birgit verfasserin aut Heier, Margit verfasserin aut Grallert, Harald verfasserin aut Schöttker, Ben verfasserin (DE-588)138862443 (DE-627)703132423 (DE-576)309375657 aut Trares, Kira 1994- verfasserin (DE-588)1221159763 (DE-627)1738319326 aut Bhardwaj, Megha 1985- verfasserin (DE-588)1147332606 (DE-627)1006074554 (DE-576)495748021 aut Gao, Xin 1989- verfasserin (DE-588)1161229086 (DE-627)1024634108 (DE-576)506422666 aut Brenner, Hermann verfasserin (DE-588)1020516445 (DE-627)691247005 (DE-576)360642136 aut Kamiński, Karol Adam verfasserin aut Paniczko, Marlena verfasserin aut Kowalska, Irina verfasserin aut Baumeister, Sebastian-Edgar verfasserin aut Meisinger, Christa verfasserin aut Enthalten in Translational research New York, NY : Elsevier, 2006 242(2022) vom: Apr., Seite 93-104 Online-Ressource (DE-627)51810365X (DE-600)2252085-5 (DE-576)261041029 1878-1810 nnns volume:242 year:2022 month:04 pages:93-104 extent:12 https://doi.org/10.1016/j.trsl.2021.11.004 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S193152442100267X Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 242 2022 4 93-104 12 2013 01 DE-16-250 413960588X 00 --%%-- --%%-- --%%-- --%%-- l01 25-05-22 2013 01 DE-16-250 00 s hd2022 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_16 2013 01 DE-16-250 03 s s_12 2013 01 DE-16-250 04 p (DE-627)1524451177 Schöttker, Ben 2013 01 DE-16-250 04 k (DE-627)143134298X Netzwerk AlternsfoRschung (NAR) 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_7 2013 01 DE-16-250 05 p (DE-627)1738319687 Trares, Kira 2013 01 DE-16-250 05 k (DE-627)143134298X Netzwerk AlternsfoRschung (NAR) 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_8 2013 01 DE-16-250 06 p (DE-627)1694602990 Bhardwaj, Megha 2013 01 DE-16-250 06 k (DE-627)1416822720 Extern 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_9 2013 01 DE-16-250 07 p (DE-627)157650316X Gao, Xin 2013 01 DE-16-250 07 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_10 2013 01 DE-16-250 08 p (DE-627)1430642343 Brenner, Hermann 2013 01 DE-16-250 08 k (DE-627)143134298X Netzwerk AlternsfoRschung (NAR) 2013 01 DE-16-250 08 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_11 |
| allfieldsSound |
10.1016/j.trsl.2021.11.004 doi (DE-627)180438710X (DE-599)KXP180438710X (OCoLC)1341460367 DE-627 ger DE-627 rda eng Ponce-de-Leon, Mariana verfasserin (DE-588)1258407434 (DE-627)1804388548 aut Novel associations between inflammation-related proteins and adiposity a targeted proteomics approach across four population-based studies Mariana Ponce-de-Leon, Jakob Linseisen, Annette Peters, Birgit Linkohr, Margit Heier, Harald Grallert, Ben Schöttker, Kira Trares, Megha Bhardwaj, Xīn Gào, Herman Brenner, Karol Adam Kamiński, Marlena Paniczko, Irina Kowalska, Sebastian-Edgar Baumeister, and Christa Meisinger 2022 12 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 25.05.2022 First published online: 12 November 2021 Chronic low-grade inflammation has been proposed as a linking mechanism between obesity and the development of inflammation-related conditions such as insulin resistance and cardiovascular disease. Despite major advances in the last 2 decades, the complex relationship between inflammation and obesity remains poorly understood. Therefore, we aimed to identify novel inflammation-related proteins associated with adiposity. We investigated the association between BMI and waist circumference and 72 circulating inflammation-related proteins, measured using the Proximity Extension Assay (Olink Proteomics), in 3,308 participants of four independent European population-based studies (KORA-Fit, BVSII, ESTHER, and Bialystok PLUS). In addition, we used body fat mass measurements obtained by Dual-energy X-ray absorptiometry (DXA) in the Bialystok PLUS study to further validate our results and to explore the relationship between inflammation-related proteins and body fat distribution. We found 14 proteins associated with at least one measure of adiposity across all four studies, including four proteins for which the association is novel: DNER, SLAMF1, RANKL, and CSF-1. We confirmed previously reported associations with CCL19, CCL28, FGF-21, HGF, IL-10RB, IL-18, IL-18R1, IL-6, SCF, and VEGF-A. The majority of the identified inflammation-related proteins were associated with visceral fat as well as with the accumulation of adipose tissue in the abdomen and the trunk. In conclusion, our study provides new insights into the immune dysregulation observed in obesity that might help uncover pathophysiological mechanisms of disease development. Linseisen, Jakob verfasserin aut Peters, Annette verfasserin aut Linkohr, Birgit verfasserin aut Heier, Margit verfasserin aut Grallert, Harald verfasserin aut Schöttker, Ben verfasserin (DE-588)138862443 (DE-627)703132423 (DE-576)309375657 aut Trares, Kira 1994- verfasserin (DE-588)1221159763 (DE-627)1738319326 aut Bhardwaj, Megha 1985- verfasserin (DE-588)1147332606 (DE-627)1006074554 (DE-576)495748021 aut Gao, Xin 1989- verfasserin (DE-588)1161229086 (DE-627)1024634108 (DE-576)506422666 aut Brenner, Hermann verfasserin (DE-588)1020516445 (DE-627)691247005 (DE-576)360642136 aut Kamiński, Karol Adam verfasserin aut Paniczko, Marlena verfasserin aut Kowalska, Irina verfasserin aut Baumeister, Sebastian-Edgar verfasserin aut Meisinger, Christa verfasserin aut Enthalten in Translational research New York, NY : Elsevier, 2006 242(2022) vom: Apr., Seite 93-104 Online-Ressource (DE-627)51810365X (DE-600)2252085-5 (DE-576)261041029 1878-1810 nnns volume:242 year:2022 month:04 pages:93-104 extent:12 https://doi.org/10.1016/j.trsl.2021.11.004 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S193152442100267X Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 242 2022 4 93-104 12 2013 01 DE-16-250 413960588X 00 --%%-- --%%-- --%%-- --%%-- l01 25-05-22 2013 01 DE-16-250 00 s hd2022 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_16 2013 01 DE-16-250 03 s s_12 2013 01 DE-16-250 04 p (DE-627)1524451177 Schöttker, Ben 2013 01 DE-16-250 04 k (DE-627)143134298X Netzwerk AlternsfoRschung (NAR) 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_7 2013 01 DE-16-250 05 p (DE-627)1738319687 Trares, Kira 2013 01 DE-16-250 05 k (DE-627)143134298X Netzwerk AlternsfoRschung (NAR) 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_8 2013 01 DE-16-250 06 p (DE-627)1694602990 Bhardwaj, Megha 2013 01 DE-16-250 06 k (DE-627)1416822720 Extern 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_9 2013 01 DE-16-250 07 p (DE-627)157650316X Gao, Xin 2013 01 DE-16-250 07 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_10 2013 01 DE-16-250 08 p (DE-627)1430642343 Brenner, Hermann 2013 01 DE-16-250 08 k (DE-627)143134298X Netzwerk AlternsfoRschung (NAR) 2013 01 DE-16-250 08 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_11 |
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Novel associations between inflammation-related proteins and adiposity a targeted proteomics approach across four population-based studies Mariana Ponce-de-Leon, Jakob Linseisen, Annette Peters, Birgit Linkohr, Margit Heier, Harald Grallert, Ben Schöttker, Kira Trares, Megha Bhardwaj, Xīn Gào, Herman Brenner, Karol Adam Kamiński, Marlena Paniczko, Irina Kowalska, Sebastian-Edgar Baumeister, and Christa Meisinger |
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Novel associations between inflammation-related proteins and adiposity a targeted proteomics approach across four population-based studies |
| abstract |
Chronic low-grade inflammation has been proposed as a linking mechanism between obesity and the development of inflammation-related conditions such as insulin resistance and cardiovascular disease. Despite major advances in the last 2 decades, the complex relationship between inflammation and obesity remains poorly understood. Therefore, we aimed to identify novel inflammation-related proteins associated with adiposity. We investigated the association between BMI and waist circumference and 72 circulating inflammation-related proteins, measured using the Proximity Extension Assay (Olink Proteomics), in 3,308 participants of four independent European population-based studies (KORA-Fit, BVSII, ESTHER, and Bialystok PLUS). In addition, we used body fat mass measurements obtained by Dual-energy X-ray absorptiometry (DXA) in the Bialystok PLUS study to further validate our results and to explore the relationship between inflammation-related proteins and body fat distribution. We found 14 proteins associated with at least one measure of adiposity across all four studies, including four proteins for which the association is novel: DNER, SLAMF1, RANKL, and CSF-1. We confirmed previously reported associations with CCL19, CCL28, FGF-21, HGF, IL-10RB, IL-18, IL-18R1, IL-6, SCF, and VEGF-A. The majority of the identified inflammation-related proteins were associated with visceral fat as well as with the accumulation of adipose tissue in the abdomen and the trunk. In conclusion, our study provides new insights into the immune dysregulation observed in obesity that might help uncover pathophysiological mechanisms of disease development. Gesehen am 25.05.2022 First published online: 12 November 2021 |
| abstractGer |
Chronic low-grade inflammation has been proposed as a linking mechanism between obesity and the development of inflammation-related conditions such as insulin resistance and cardiovascular disease. Despite major advances in the last 2 decades, the complex relationship between inflammation and obesity remains poorly understood. Therefore, we aimed to identify novel inflammation-related proteins associated with adiposity. We investigated the association between BMI and waist circumference and 72 circulating inflammation-related proteins, measured using the Proximity Extension Assay (Olink Proteomics), in 3,308 participants of four independent European population-based studies (KORA-Fit, BVSII, ESTHER, and Bialystok PLUS). In addition, we used body fat mass measurements obtained by Dual-energy X-ray absorptiometry (DXA) in the Bialystok PLUS study to further validate our results and to explore the relationship between inflammation-related proteins and body fat distribution. We found 14 proteins associated with at least one measure of adiposity across all four studies, including four proteins for which the association is novel: DNER, SLAMF1, RANKL, and CSF-1. We confirmed previously reported associations with CCL19, CCL28, FGF-21, HGF, IL-10RB, IL-18, IL-18R1, IL-6, SCF, and VEGF-A. The majority of the identified inflammation-related proteins were associated with visceral fat as well as with the accumulation of adipose tissue in the abdomen and the trunk. In conclusion, our study provides new insights into the immune dysregulation observed in obesity that might help uncover pathophysiological mechanisms of disease development. Gesehen am 25.05.2022 First published online: 12 November 2021 |
| abstract_unstemmed |
Chronic low-grade inflammation has been proposed as a linking mechanism between obesity and the development of inflammation-related conditions such as insulin resistance and cardiovascular disease. Despite major advances in the last 2 decades, the complex relationship between inflammation and obesity remains poorly understood. Therefore, we aimed to identify novel inflammation-related proteins associated with adiposity. We investigated the association between BMI and waist circumference and 72 circulating inflammation-related proteins, measured using the Proximity Extension Assay (Olink Proteomics), in 3,308 participants of four independent European population-based studies (KORA-Fit, BVSII, ESTHER, and Bialystok PLUS). In addition, we used body fat mass measurements obtained by Dual-energy X-ray absorptiometry (DXA) in the Bialystok PLUS study to further validate our results and to explore the relationship between inflammation-related proteins and body fat distribution. We found 14 proteins associated with at least one measure of adiposity across all four studies, including four proteins for which the association is novel: DNER, SLAMF1, RANKL, and CSF-1. We confirmed previously reported associations with CCL19, CCL28, FGF-21, HGF, IL-10RB, IL-18, IL-18R1, IL-6, SCF, and VEGF-A. The majority of the identified inflammation-related proteins were associated with visceral fat as well as with the accumulation of adipose tissue in the abdomen and the trunk. In conclusion, our study provides new insights into the immune dysregulation observed in obesity that might help uncover pathophysiological mechanisms of disease development. Gesehen am 25.05.2022 First published online: 12 November 2021 |
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| title_short |
Novel associations between inflammation-related proteins and adiposity |
| url |
https://doi.org/10.1016/j.trsl.2021.11.004 https://www.sciencedirect.com/science/article/pii/S193152442100267X |
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| author2Str |
Linseisen, Jakob Peters, Annette Linkohr, Birgit Heier, Margit Grallert, Harald Schöttker, Ben Trares, Kira 1994- Bhardwaj, Megha 1985- Gao, Xin 1989- Brenner, Hermann Kamiński, Karol Adam Paniczko, Marlena Kowalska, Irina Baumeister, Sebastian-Edgar Meisinger, Christa |
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Ponce de Leon Rodriguez, Mariana Ponce-de-Leon, Mariana Schoettker, Ben Schöttker, Ben Trares, Kira M. Trares, Kira Martina Trares, Kira Bhardwaj, Megha Gào, Xīn Gao, Xin Brenner, H. Brenner, Herrmann Brenner, Hermann |
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