Preoperative systemic treatment in BRCA-positive breast cancer patients : case report and review of the literature

Background: In vitro and in vivo analyses have shown differences in chemosensitivity between breast cancers associated with BRCA1/2 mutations compared to sporadic variants. In the preoperative setting, the tumor response can be directly measured. Therefore, preoperative systemic treatment (PST) offe...
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Gespeichert in:

Autor*in:	Schott, Sarah - 1981- [verfasserIn] Sohn, Christof - 1961- [verfasserIn] Schneeweiss, Andreas - 1961- [verfasserIn] Heil, Jörg - 1978- [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	October 2011

Anmerkung:	Gesehen am 26.10.2022
Umfang:	4

Übergeordnetes Werk:	Enthalten in: Breast care - Basel : Karger, 2006, 6(2011), 5 vom: Okt., Seite 395-398
Übergeordnetes Werk:	volume:6 ; year:2011 ; number:5 ; month:10 ; pages:395-398 ; extent:4

Links:	Volltext Volltext

DOI / URN:	10.1159/000333129

Katalog-ID:	1820016781

Internformat


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245	1	0	\|a Preoperative systemic treatment in BRCA-positive breast cancer patients \|b case report and review of the literature \|c Sarah Schott, Christof Sohn, Andreas Schneeweiss, Joerg Heil (University Hospital Heidelberg, Women’s Hospital, National Center of Tumor Disease, Heidelberg, Germany)
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520			\|a Background: In vitro and in vivo analyses have shown differences in chemosensitivity between breast cancers associated with BRCA1/2 mutations compared to sporadic variants. In the preoperative setting, the tumor response can be directly measured. Therefore, preoperative systemic treatment (PST) offers the opportunity to assess the chemosensitivity in vivo. However, there have been neither clear guidelines for mutation carriers in terms of choice of chemotherapy regimen nor recommendations how to proceed in case of an inadequate response to PST. Case Report: Herein, we present the history of a 39-year-old woman with bilateral breast cancer who was tested positive for germ-line BRCA1 mutation while under PST. We performed a comprehensive literature review covering the MEDLINE database from 1992 to 2010 on published data regarding PST options for BRCA mutation carriers. Conclusions: If results of genetic testing are obtained during PST, individual therapy adaptations can be discussed with respect to mainly retrospective data of response to specific drugs. However, larger studies with longer follow-up are eagerly needed to draw firm conclusions before any specific treatment recommendations can be given for BRCA mutation carriers. PST is an ideal setting to evaluate such treatment options and to describe predictive markers that can help define subgroups that benefit most.
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author_variant	s s ss c s cs a s as j h jh
matchkey_str	article:16613805:2011----::roeaieytmcramnibcpstvb
oclc_num	1389759894
hierarchy_sort_str	[October 2011]
publishDate	2011
allfields	10.1159/000333129 doi (DE-627)1820016781 (DE-599)KXP1820016781 (OCoLC)1389759894 DE-627 ger DE-627 rda eng Schott, Sarah 1981- verfasserin (DE-588)133730816 (DE-627)552697281 (DE-576)27460678X aut Preoperative systemic treatment in BRCA-positive breast cancer patients case report and review of the literature Sarah Schott, Christof Sohn, Andreas Schneeweiss, Joerg Heil (University Hospital Heidelberg, Women’s Hospital, National Center of Tumor Disease, Heidelberg, Germany) [October 2011] 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 26.10.2022 Background: In vitro and in vivo analyses have shown differences in chemosensitivity between breast cancers associated with BRCA1/2 mutations compared to sporadic variants. In the preoperative setting, the tumor response can be directly measured. Therefore, preoperative systemic treatment (PST) offers the opportunity to assess the chemosensitivity in vivo. However, there have been neither clear guidelines for mutation carriers in terms of choice of chemotherapy regimen nor recommendations how to proceed in case of an inadequate response to PST. Case Report: Herein, we present the history of a 39-year-old woman with bilateral breast cancer who was tested positive for germ-line BRCA1 mutation while under PST. We performed a comprehensive literature review covering the MEDLINE database from 1992 to 2010 on published data regarding PST options for BRCA mutation carriers. Conclusions: If results of genetic testing are obtained during PST, individual therapy adaptations can be discussed with respect to mainly retrospective data of response to specific drugs. However, larger studies with longer follow-up are eagerly needed to draw firm conclusions before any specific treatment recommendations can be given for BRCA mutation carriers. PST is an ideal setting to evaluate such treatment options and to describe predictive markers that can help define subgroups that benefit most. Sohn, Christof 1961- verfasserin (DE-588)131349287 (DE-627)507642902 (DE-576)298422255 aut Schneeweiss, Andreas 1961- verfasserin (DE-588)109972554 (DE-627)632849630 (DE-576)327251859 aut Heil, Jörg 1978- verfasserin (DE-588)132580187 (DE-627)52396160X (DE-576)299238679 aut Enthalten in Breast care Basel : Karger, 2006 6(2011), 5 vom: Okt., Seite 395-398 Online-Ressource (DE-627)501078142 (DE-600)2205941-6 (DE-576)276272617 1661-3805 nnns volume:6 year:2011 number:5 month:10 pages:395-398 extent:4 https://doi.org/10.1159/000333129 Verlag Resolving-System lizenzpflichtig Volltext https://www.karger.com/Article/FullText/333129 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_4753 AR 6 2011 5 10 395-398 4 2013 01 DE-16-250 420206500X 00 --%%-- --%%-- --%%-- --%%-- l01 26-10-22 2013 01 DE-16-250 00 s hd2011 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_4 2013 01 DE-16-250 03 s s_4 2013 01 DE-16-250 04 p (DE-627)1448427479 Schott, Sarah 2013 01 DE-16-250 04 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1436088836 Sohn, Christof 2013 01 DE-16-250 05 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1436041317 Schneeweiss, Andreas 2013 01 DE-16-250 06 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_3 2013 01 DE-16-250 07 p (DE-627)1436088623 Heil, Jörg 2013 01 DE-16-250 07 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_4
spelling	10.1159/000333129 doi (DE-627)1820016781 (DE-599)KXP1820016781 (OCoLC)1389759894 DE-627 ger DE-627 rda eng Schott, Sarah 1981- verfasserin (DE-588)133730816 (DE-627)552697281 (DE-576)27460678X aut Preoperative systemic treatment in BRCA-positive breast cancer patients case report and review of the literature Sarah Schott, Christof Sohn, Andreas Schneeweiss, Joerg Heil (University Hospital Heidelberg, Women’s Hospital, National Center of Tumor Disease, Heidelberg, Germany) [October 2011] 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 26.10.2022 Background: In vitro and in vivo analyses have shown differences in chemosensitivity between breast cancers associated with BRCA1/2 mutations compared to sporadic variants. In the preoperative setting, the tumor response can be directly measured. Therefore, preoperative systemic treatment (PST) offers the opportunity to assess the chemosensitivity in vivo. However, there have been neither clear guidelines for mutation carriers in terms of choice of chemotherapy regimen nor recommendations how to proceed in case of an inadequate response to PST. Case Report: Herein, we present the history of a 39-year-old woman with bilateral breast cancer who was tested positive for germ-line BRCA1 mutation while under PST. We performed a comprehensive literature review covering the MEDLINE database from 1992 to 2010 on published data regarding PST options for BRCA mutation carriers. Conclusions: If results of genetic testing are obtained during PST, individual therapy adaptations can be discussed with respect to mainly retrospective data of response to specific drugs. However, larger studies with longer follow-up are eagerly needed to draw firm conclusions before any specific treatment recommendations can be given for BRCA mutation carriers. PST is an ideal setting to evaluate such treatment options and to describe predictive markers that can help define subgroups that benefit most. Sohn, Christof 1961- verfasserin (DE-588)131349287 (DE-627)507642902 (DE-576)298422255 aut Schneeweiss, Andreas 1961- verfasserin (DE-588)109972554 (DE-627)632849630 (DE-576)327251859 aut Heil, Jörg 1978- verfasserin (DE-588)132580187 (DE-627)52396160X (DE-576)299238679 aut Enthalten in Breast care Basel : Karger, 2006 6(2011), 5 vom: Okt., Seite 395-398 Online-Ressource (DE-627)501078142 (DE-600)2205941-6 (DE-576)276272617 1661-3805 nnns volume:6 year:2011 number:5 month:10 pages:395-398 extent:4 https://doi.org/10.1159/000333129 Verlag Resolving-System lizenzpflichtig Volltext https://www.karger.com/Article/FullText/333129 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_4753 AR 6 2011 5 10 395-398 4 2013 01 DE-16-250 420206500X 00 --%%-- --%%-- --%%-- --%%-- l01 26-10-22 2013 01 DE-16-250 00 s hd2011 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_4 2013 01 DE-16-250 03 s s_4 2013 01 DE-16-250 04 p (DE-627)1448427479 Schott, Sarah 2013 01 DE-16-250 04 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1436088836 Sohn, Christof 2013 01 DE-16-250 05 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1436041317 Schneeweiss, Andreas 2013 01 DE-16-250 06 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_3 2013 01 DE-16-250 07 p (DE-627)1436088623 Heil, Jörg 2013 01 DE-16-250 07 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_4
allfields_unstemmed	10.1159/000333129 doi (DE-627)1820016781 (DE-599)KXP1820016781 (OCoLC)1389759894 DE-627 ger DE-627 rda eng Schott, Sarah 1981- verfasserin (DE-588)133730816 (DE-627)552697281 (DE-576)27460678X aut Preoperative systemic treatment in BRCA-positive breast cancer patients case report and review of the literature Sarah Schott, Christof Sohn, Andreas Schneeweiss, Joerg Heil (University Hospital Heidelberg, Women’s Hospital, National Center of Tumor Disease, Heidelberg, Germany) [October 2011] 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 26.10.2022 Background: In vitro and in vivo analyses have shown differences in chemosensitivity between breast cancers associated with BRCA1/2 mutations compared to sporadic variants. In the preoperative setting, the tumor response can be directly measured. Therefore, preoperative systemic treatment (PST) offers the opportunity to assess the chemosensitivity in vivo. However, there have been neither clear guidelines for mutation carriers in terms of choice of chemotherapy regimen nor recommendations how to proceed in case of an inadequate response to PST. Case Report: Herein, we present the history of a 39-year-old woman with bilateral breast cancer who was tested positive for germ-line BRCA1 mutation while under PST. We performed a comprehensive literature review covering the MEDLINE database from 1992 to 2010 on published data regarding PST options for BRCA mutation carriers. Conclusions: If results of genetic testing are obtained during PST, individual therapy adaptations can be discussed with respect to mainly retrospective data of response to specific drugs. However, larger studies with longer follow-up are eagerly needed to draw firm conclusions before any specific treatment recommendations can be given for BRCA mutation carriers. PST is an ideal setting to evaluate such treatment options and to describe predictive markers that can help define subgroups that benefit most. Sohn, Christof 1961- verfasserin (DE-588)131349287 (DE-627)507642902 (DE-576)298422255 aut Schneeweiss, Andreas 1961- verfasserin (DE-588)109972554 (DE-627)632849630 (DE-576)327251859 aut Heil, Jörg 1978- verfasserin (DE-588)132580187 (DE-627)52396160X (DE-576)299238679 aut Enthalten in Breast care Basel : Karger, 2006 6(2011), 5 vom: Okt., Seite 395-398 Online-Ressource (DE-627)501078142 (DE-600)2205941-6 (DE-576)276272617 1661-3805 nnns volume:6 year:2011 number:5 month:10 pages:395-398 extent:4 https://doi.org/10.1159/000333129 Verlag Resolving-System lizenzpflichtig Volltext https://www.karger.com/Article/FullText/333129 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_4753 AR 6 2011 5 10 395-398 4 2013 01 DE-16-250 420206500X 00 --%%-- --%%-- --%%-- --%%-- l01 26-10-22 2013 01 DE-16-250 00 s hd2011 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_4 2013 01 DE-16-250 03 s s_4 2013 01 DE-16-250 04 p (DE-627)1448427479 Schott, Sarah 2013 01 DE-16-250 04 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1436088836 Sohn, Christof 2013 01 DE-16-250 05 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1436041317 Schneeweiss, Andreas 2013 01 DE-16-250 06 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_3 2013 01 DE-16-250 07 p (DE-627)1436088623 Heil, Jörg 2013 01 DE-16-250 07 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_4
allfieldsGer	10.1159/000333129 doi (DE-627)1820016781 (DE-599)KXP1820016781 (OCoLC)1389759894 DE-627 ger DE-627 rda eng Schott, Sarah 1981- verfasserin (DE-588)133730816 (DE-627)552697281 (DE-576)27460678X aut Preoperative systemic treatment in BRCA-positive breast cancer patients case report and review of the literature Sarah Schott, Christof Sohn, Andreas Schneeweiss, Joerg Heil (University Hospital Heidelberg, Women’s Hospital, National Center of Tumor Disease, Heidelberg, Germany) [October 2011] 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 26.10.2022 Background: In vitro and in vivo analyses have shown differences in chemosensitivity between breast cancers associated with BRCA1/2 mutations compared to sporadic variants. In the preoperative setting, the tumor response can be directly measured. Therefore, preoperative systemic treatment (PST) offers the opportunity to assess the chemosensitivity in vivo. However, there have been neither clear guidelines for mutation carriers in terms of choice of chemotherapy regimen nor recommendations how to proceed in case of an inadequate response to PST. Case Report: Herein, we present the history of a 39-year-old woman with bilateral breast cancer who was tested positive for germ-line BRCA1 mutation while under PST. We performed a comprehensive literature review covering the MEDLINE database from 1992 to 2010 on published data regarding PST options for BRCA mutation carriers. Conclusions: If results of genetic testing are obtained during PST, individual therapy adaptations can be discussed with respect to mainly retrospective data of response to specific drugs. However, larger studies with longer follow-up are eagerly needed to draw firm conclusions before any specific treatment recommendations can be given for BRCA mutation carriers. PST is an ideal setting to evaluate such treatment options and to describe predictive markers that can help define subgroups that benefit most. Sohn, Christof 1961- verfasserin (DE-588)131349287 (DE-627)507642902 (DE-576)298422255 aut Schneeweiss, Andreas 1961- verfasserin (DE-588)109972554 (DE-627)632849630 (DE-576)327251859 aut Heil, Jörg 1978- verfasserin (DE-588)132580187 (DE-627)52396160X (DE-576)299238679 aut Enthalten in Breast care Basel : Karger, 2006 6(2011), 5 vom: Okt., Seite 395-398 Online-Ressource (DE-627)501078142 (DE-600)2205941-6 (DE-576)276272617 1661-3805 nnns volume:6 year:2011 number:5 month:10 pages:395-398 extent:4 https://doi.org/10.1159/000333129 Verlag Resolving-System lizenzpflichtig Volltext https://www.karger.com/Article/FullText/333129 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_4753 AR 6 2011 5 10 395-398 4 2013 01 DE-16-250 420206500X 00 --%%-- --%%-- --%%-- --%%-- l01 26-10-22 2013 01 DE-16-250 00 s hd2011 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_4 2013 01 DE-16-250 03 s s_4 2013 01 DE-16-250 04 p (DE-627)1448427479 Schott, Sarah 2013 01 DE-16-250 04 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1436088836 Sohn, Christof 2013 01 DE-16-250 05 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1436041317 Schneeweiss, Andreas 2013 01 DE-16-250 06 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_3 2013 01 DE-16-250 07 p (DE-627)1436088623 Heil, Jörg 2013 01 DE-16-250 07 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_4
allfieldsSound	10.1159/000333129 doi (DE-627)1820016781 (DE-599)KXP1820016781 (OCoLC)1389759894 DE-627 ger DE-627 rda eng Schott, Sarah 1981- verfasserin (DE-588)133730816 (DE-627)552697281 (DE-576)27460678X aut Preoperative systemic treatment in BRCA-positive breast cancer patients case report and review of the literature Sarah Schott, Christof Sohn, Andreas Schneeweiss, Joerg Heil (University Hospital Heidelberg, Women’s Hospital, National Center of Tumor Disease, Heidelberg, Germany) [October 2011] 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 26.10.2022 Background: In vitro and in vivo analyses have shown differences in chemosensitivity between breast cancers associated with BRCA1/2 mutations compared to sporadic variants. In the preoperative setting, the tumor response can be directly measured. Therefore, preoperative systemic treatment (PST) offers the opportunity to assess the chemosensitivity in vivo. However, there have been neither clear guidelines for mutation carriers in terms of choice of chemotherapy regimen nor recommendations how to proceed in case of an inadequate response to PST. Case Report: Herein, we present the history of a 39-year-old woman with bilateral breast cancer who was tested positive for germ-line BRCA1 mutation while under PST. We performed a comprehensive literature review covering the MEDLINE database from 1992 to 2010 on published data regarding PST options for BRCA mutation carriers. Conclusions: If results of genetic testing are obtained during PST, individual therapy adaptations can be discussed with respect to mainly retrospective data of response to specific drugs. However, larger studies with longer follow-up are eagerly needed to draw firm conclusions before any specific treatment recommendations can be given for BRCA mutation carriers. PST is an ideal setting to evaluate such treatment options and to describe predictive markers that can help define subgroups that benefit most. Sohn, Christof 1961- verfasserin (DE-588)131349287 (DE-627)507642902 (DE-576)298422255 aut Schneeweiss, Andreas 1961- verfasserin (DE-588)109972554 (DE-627)632849630 (DE-576)327251859 aut Heil, Jörg 1978- verfasserin (DE-588)132580187 (DE-627)52396160X (DE-576)299238679 aut Enthalten in Breast care Basel : Karger, 2006 6(2011), 5 vom: Okt., Seite 395-398 Online-Ressource (DE-627)501078142 (DE-600)2205941-6 (DE-576)276272617 1661-3805 nnns volume:6 year:2011 number:5 month:10 pages:395-398 extent:4 https://doi.org/10.1159/000333129 Verlag Resolving-System lizenzpflichtig Volltext https://www.karger.com/Article/FullText/333129 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_4753 AR 6 2011 5 10 395-398 4 2013 01 DE-16-250 420206500X 00 --%%-- --%%-- --%%-- --%%-- l01 26-10-22 2013 01 DE-16-250 00 s hd2011 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_4 2013 01 DE-16-250 03 s s_4 2013 01 DE-16-250 04 p (DE-627)1448427479 Schott, Sarah 2013 01 DE-16-250 04 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1436088836 Sohn, Christof 2013 01 DE-16-250 05 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1436041317 Schneeweiss, Andreas 2013 01 DE-16-250 06 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_3 2013 01 DE-16-250 07 p (DE-627)1436088623 Heil, Jörg 2013 01 DE-16-250 07 k (DE-627)1416740961 Universitäts-Frauenklinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_4
language	English
source	Enthalten in Breast care 6(2011), 5 vom: Okt., Seite 395-398 volume:6 year:2011 number:5 month:10 pages:395-398 extent:4
sourceStr	Enthalten in Breast care 6(2011), 5 vom: Okt., Seite 395-398 volume:6 year:2011 number:5 month:10 pages:395-398 extent:4
format_phy_str_mv	Article
building	2013:0
institution	findex.gbv.de
selectbib_iln_str_mv	2013@01
sw_local_iln_str_mv	2013:hd2011 DE-16-250:hd2011 2013:wissenschaftlicher Artikel (Zeitschrift) DE-16-250:wissenschaftlicher Artikel (Zeitschrift) 2013:per_4 DE-16-250:per_4 2013:s_4 DE-16-250:s_4 2013:Schott, Sarah DE-16-250:Schott, Sarah 2013:Universitäts-Frauenklinik DE-16-250:Universitäts-Frauenklinik 2013:Verfasser DE-16-250:Verfasser 2013:pos_1 DE-16-250:pos_1 2013:Sohn, Christof DE-16-250:Sohn, Christof 2013:pos_2 DE-16-250:pos_2 2013:Schneeweiss, Andreas DE-16-250:Schneeweiss, Andreas 2013:pos_3 DE-16-250:pos_3 2013:Heil, Jörg DE-16-250:Heil, Jörg 2013:pos_4 DE-16-250:pos_4
isfreeaccess_bool	false
container_title	Breast care
authorswithroles_txt_mv	Schott, Sarah @@aut@@ Sohn, Christof @@aut@@ Schneeweiss, Andreas @@aut@@ Heil, Jörg @@aut@@
publishDateDaySort_date	2011-10-01T00:00:00Z
hierarchy_top_id	501078142
id	1820016781
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">1820016781</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230710105009.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">221026s2011 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1159/000333129</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)1820016781</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)KXP1820016781</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1389759894</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Schott, Sarah</subfield><subfield code="d">1981-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)133730816</subfield><subfield code="0">(DE-627)552697281</subfield><subfield code="0">(DE-576)27460678X</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Preoperative systemic treatment in BRCA-positive breast cancer patients</subfield><subfield code="b">case report and review of the literature</subfield><subfield code="c">Sarah Schott, Christof Sohn, Andreas Schneeweiss, Joerg Heil (University Hospital Heidelberg, Women’s Hospital, National Center of Tumor Disease, Heidelberg, Germany)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">[October 2011]</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">4</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Gesehen am 26.10.2022</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: In vitro and in vivo analyses have shown differences in chemosensitivity between breast cancers associated with BRCA1/2 mutations compared to sporadic variants. In the preoperative setting, the tumor response can be directly measured. Therefore, preoperative systemic treatment (PST) offers the opportunity to assess the chemosensitivity in vivo. However, there have been neither clear guidelines for mutation carriers in terms of choice of chemotherapy regimen nor recommendations how to proceed in case of an inadequate response to PST. Case Report: Herein, we present the history of a 39-year-old woman with bilateral breast cancer who was tested positive for germ-line BRCA1 mutation while under PST. We performed a comprehensive literature review covering the MEDLINE database from 1992 to 2010 on published data regarding PST options for BRCA mutation carriers. Conclusions: If results of genetic testing are obtained during PST, individual therapy adaptations can be discussed with respect to mainly retrospective data of response to specific drugs. However, larger studies with longer follow-up are eagerly needed to draw firm conclusions before any specific treatment recommendations can be given for BRCA mutation carriers. 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title_full	Preoperative systemic treatment in BRCA-positive breast cancer patients case report and review of the literature Sarah Schott, Christof Sohn, Andreas Schneeweiss, Joerg Heil (University Hospital Heidelberg, Women’s Hospital, National Center of Tumor Disease, Heidelberg, Germany)
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title_sort	preoperative systemic treatment in brca-positive breast cancer patientscase report and review of the literature
title_auth	Preoperative systemic treatment in BRCA-positive breast cancer patients case report and review of the literature
abstract	Background: In vitro and in vivo analyses have shown differences in chemosensitivity between breast cancers associated with BRCA1/2 mutations compared to sporadic variants. In the preoperative setting, the tumor response can be directly measured. Therefore, preoperative systemic treatment (PST) offers the opportunity to assess the chemosensitivity in vivo. However, there have been neither clear guidelines for mutation carriers in terms of choice of chemotherapy regimen nor recommendations how to proceed in case of an inadequate response to PST. Case Report: Herein, we present the history of a 39-year-old woman with bilateral breast cancer who was tested positive for germ-line BRCA1 mutation while under PST. We performed a comprehensive literature review covering the MEDLINE database from 1992 to 2010 on published data regarding PST options for BRCA mutation carriers. Conclusions: If results of genetic testing are obtained during PST, individual therapy adaptations can be discussed with respect to mainly retrospective data of response to specific drugs. However, larger studies with longer follow-up are eagerly needed to draw firm conclusions before any specific treatment recommendations can be given for BRCA mutation carriers. PST is an ideal setting to evaluate such treatment options and to describe predictive markers that can help define subgroups that benefit most. Gesehen am 26.10.2022
abstractGer	Background: In vitro and in vivo analyses have shown differences in chemosensitivity between breast cancers associated with BRCA1/2 mutations compared to sporadic variants. In the preoperative setting, the tumor response can be directly measured. Therefore, preoperative systemic treatment (PST) offers the opportunity to assess the chemosensitivity in vivo. However, there have been neither clear guidelines for mutation carriers in terms of choice of chemotherapy regimen nor recommendations how to proceed in case of an inadequate response to PST. Case Report: Herein, we present the history of a 39-year-old woman with bilateral breast cancer who was tested positive for germ-line BRCA1 mutation while under PST. We performed a comprehensive literature review covering the MEDLINE database from 1992 to 2010 on published data regarding PST options for BRCA mutation carriers. Conclusions: If results of genetic testing are obtained during PST, individual therapy adaptations can be discussed with respect to mainly retrospective data of response to specific drugs. However, larger studies with longer follow-up are eagerly needed to draw firm conclusions before any specific treatment recommendations can be given for BRCA mutation carriers. PST is an ideal setting to evaluate such treatment options and to describe predictive markers that can help define subgroups that benefit most. Gesehen am 26.10.2022
abstract_unstemmed	Background: In vitro and in vivo analyses have shown differences in chemosensitivity between breast cancers associated with BRCA1/2 mutations compared to sporadic variants. In the preoperative setting, the tumor response can be directly measured. Therefore, preoperative systemic treatment (PST) offers the opportunity to assess the chemosensitivity in vivo. However, there have been neither clear guidelines for mutation carriers in terms of choice of chemotherapy regimen nor recommendations how to proceed in case of an inadequate response to PST. Case Report: Herein, we present the history of a 39-year-old woman with bilateral breast cancer who was tested positive for germ-line BRCA1 mutation while under PST. We performed a comprehensive literature review covering the MEDLINE database from 1992 to 2010 on published data regarding PST options for BRCA mutation carriers. Conclusions: If results of genetic testing are obtained during PST, individual therapy adaptations can be discussed with respect to mainly retrospective data of response to specific drugs. However, larger studies with longer follow-up are eagerly needed to draw firm conclusions before any specific treatment recommendations can be given for BRCA mutation carriers. PST is an ideal setting to evaluate such treatment options and to describe predictive markers that can help define subgroups that benefit most. Gesehen am 26.10.2022
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title_short	Preoperative systemic treatment in BRCA-positive breast cancer patients
url	https://doi.org/10.1159/000333129 https://www.karger.com/Article/FullText/333129
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Preoperative systemic treatment in BRCA-positive breast cancer patients : case report and review of the literature

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