High-risk additional chromosomal abnormalities at low blast counts herald death by CML
Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a timelier change of treatment is unknown. One thousand five hundred and ten imatinib-treated pat...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hehlmann, Rüdiger - 1941- [verfasserIn] Voskanyan, Astghik - 1973- [verfasserIn] Lauseker, Michael - 1981- [verfasserIn] Pfirrmann, Markus - 1967- [verfasserIn] Kalmanti, Lida [verfasserIn] Rinaldetti, Sébastien - 1988- [verfasserIn] Kohlbrenner, Katharina - 1970- [verfasserIn] Haferlach, Claudia [verfasserIn] Schlegelberger, Brigitte - 1956- [verfasserIn] Fabarius, Alice - 1965- [verfasserIn] Seifarth, Wolfgang - 1960- [verfasserIn] Spiess, Birgit - 1972- [verfasserIn] Wuchter, Patrick - 1975- [verfasserIn] Krause, Stefan [verfasserIn] Kolb, Hans-Jochem - 1944- [verfasserIn] Neubauer, Andreas - 1958- [verfasserIn] Hossfeld, Dieter K. - 1938- [verfasserIn] Nerl, Christoph [verfasserIn] Gratwohl, Alois - 1947- [verfasserIn] Baerlocher, Gabriela M. [verfasserIn] Burchert, Andreas - 1969- [verfasserIn] Brümmendorf, Tim Henrik - 1966- [verfasserIn] Hasford, Jörg [verfasserIn] Hochhaus, Andreas - 1959- [verfasserIn] Saußele, Susanne - 1968- [verfasserIn] Baccarani, Michele - 1942-2021 [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
07 May 2020 |
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| Schlagwörter: |
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| Anmerkung: |
Gesehen am 08.08.2023 |
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| Umfang: |
13 |
| Weitere Ausgabe: |
Ergänzung Hehlmann, Rüdiger, 1941 -: Impact of emerging ACA on survival in chronic myeloid leukemia (CML) - 2022 |
|---|---|
| Übergeordnetes Werk: |
Enthalten in: Leukemia - London : Springer Nature, 1997, 34(2020), 8, Seite 2074-2086 |
| Übergeordnetes Werk: |
volume:34 ; year:2020 ; number:8 ; pages:2074-2086 ; extent:13 |
| Links: |
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| DOI / URN: |
10.1038/s41375-020-0826-9 |
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| Katalog-ID: |
1854628607 |
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| 245 | 1 | 0 | |a High-risk additional chromosomal abnormalities at low blast counts herald death by CML |c Rüdiger Hehlmann, Astghik Voskanyan, Michael Lauseker, Markus Pfirrmann, Lida Kalmanti, Sebastien Rinaldetti, Katharina Kohlbrenner, Claudia Haferlach, Brigitte Schlegelberger, Alice Fabarius, Wolfgang Seifarth, Birgit Spieß, Patrick Wuchter, Stefan Krause, Hans-Jochem Kolb, Andreas Neubauer, Dieter K. Hossfeld, Christoph Nerl, Alois Gratwohl, Gabriela M. Baerlocher, Andreas Burchert, Tim H. Brümmendorf, Jörg Hasford, Andreas Hochhaus, Susanne Saußele, Michele Baccarani for the SAKK and the German CML Study Group |
| 264 | 1 | |c 07 May 2020 | |
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| 500 | |a Gesehen am 08.08.2023 | ||
| 520 | |a Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a timelier change of treatment is unknown. One thousand five hundred and ten imatinib-treated patients with Philadelphia-chromosome-positive (Ph+) CML randomized in CML-study IV were analyzed for ACA/Ph+ and blast increase. By impact on survival, ACAs were grouped into high risk (+8, +Ph, i(17q), +17, +19, +21, 3q26.2, 11q23, −7/7q abnormalities; complex) and low risk (all other). The presence of high- and low-risk ACAs was linked to six cohorts with different blast levels (1%, 5%, 10%, 15%, 20%, and 30%) in a Cox model. One hundred and twenty-three patients displayed ACA/Ph+ (8.1%), 91 were high risk. At low blast levels (1-15%), high-risk ACA showed an increased hazard to die compared to no ACA (ratios: 3.65 in blood; 6.12 in marrow) in contrast to low-risk ACA. No effect was observed at blast levels of 20-30%. Sixty-three patients with high-risk ACA (69%) died (n = 37) or were alive after progression or progression-related transplantation (n = 26). High-risk ACA at low blast counts identify end-phase CML earlier than current diagnostic systems. Mortality was lower with earlier treatment. Cytogenetic monitoring is indicated when signs of progression surface or response to therapy is unsatisfactory. | ||
| 650 | 4 | |a Genetics research | |
| 650 | 4 | |a Translational research | |
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2020 |
| allfields |
10.1038/s41375-020-0826-9 doi (DE-627)1854628607 (DE-599)KXP1854628607 (OCoLC)1425217961 DE-627 ger DE-627 rda eng Hehlmann, Rüdiger 1941- verfasserin (DE-588)1037003489 (DE-627)751737879 (DE-576)390939463 aut High-risk additional chromosomal abnormalities at low blast counts herald death by CML Rüdiger Hehlmann, Astghik Voskanyan, Michael Lauseker, Markus Pfirrmann, Lida Kalmanti, Sebastien Rinaldetti, Katharina Kohlbrenner, Claudia Haferlach, Brigitte Schlegelberger, Alice Fabarius, Wolfgang Seifarth, Birgit Spieß, Patrick Wuchter, Stefan Krause, Hans-Jochem Kolb, Andreas Neubauer, Dieter K. Hossfeld, Christoph Nerl, Alois Gratwohl, Gabriela M. Baerlocher, Andreas Burchert, Tim H. Brümmendorf, Jörg Hasford, Andreas Hochhaus, Susanne Saußele, Michele Baccarani for the SAKK and the German CML Study Group 07 May 2020 13 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 08.08.2023 Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a timelier change of treatment is unknown. One thousand five hundred and ten imatinib-treated patients with Philadelphia-chromosome-positive (Ph+) CML randomized in CML-study IV were analyzed for ACA/Ph+ and blast increase. By impact on survival, ACAs were grouped into high risk (+8, +Ph, i(17q), +17, +19, +21, 3q26.2, 11q23, −7/7q abnormalities; complex) and low risk (all other). The presence of high- and low-risk ACAs was linked to six cohorts with different blast levels (1%, 5%, 10%, 15%, 20%, and 30%) in a Cox model. One hundred and twenty-three patients displayed ACA/Ph+ (8.1%), 91 were high risk. At low blast levels (1-15%), high-risk ACA showed an increased hazard to die compared to no ACA (ratios: 3.65 in blood; 6.12 in marrow) in contrast to low-risk ACA. No effect was observed at blast levels of 20-30%. Sixty-three patients with high-risk ACA (69%) died (n = 37) or were alive after progression or progression-related transplantation (n = 26). High-risk ACA at low blast counts identify end-phase CML earlier than current diagnostic systems. Mortality was lower with earlier treatment. Cytogenetic monitoring is indicated when signs of progression surface or response to therapy is unsatisfactory. Genetics research Translational research Voskanyan, Astghik 1973- verfasserin (DE-588)1152344005 (DE-627)1013874706 (DE-576)499833732 aut Lauseker, Michael 1981- verfasserin (DE-588)1058710265 (DE-627)79743223X (DE-576)414848438 aut Pfirrmann, Markus 1967- verfasserin (DE-588)133124932 (DE-627)534963617 (DE-576)299639835 aut Kalmanti, Lida verfasserin (DE-588)1067216995 (DE-627)818440961 (DE-576)426472586 aut Rinaldetti, Sébastien 1988- verfasserin (DE-588)1073669157 (DE-627)829329730 (DE-576)435254952 aut Kohlbrenner, Katharina 1970- verfasserin (DE-588)128734647 (DE-627)378683772 (DE-576)297304968 aut Haferlach, Claudia verfasserin (DE-588)1206213272 (DE-627)1691999199 aut Schlegelberger, Brigitte 1956- verfasserin (DE-588)133666115 (DE-627)550183779 (DE-576)30001029X aut Fabarius, Alice 1965- verfasserin (DE-588)1037001281 (DE-627)751728314 (DE-576)390896667 aut Seifarth, Wolfgang 1960- verfasserin (DE-588)1042491887 (DE-627)769066453 (DE-576)393988899 aut Spiess, Birgit 1972- verfasserin (DE-588)1028287496 (DE-627)730538699 (DE-576)37578764X aut Wuchter, Patrick 1975- verfasserin (DE-588)123450284 (DE-627)082563624 (DE-576)184642574 aut Krause, Stefan verfasserin aut Kolb, Hans-Jochem 1944- verfasserin (DE-588)133476219 (DE-627)691487162 (DE-576)299873625 aut Neubauer, Andreas 1958- verfasserin (DE-588)136452981 (DE-627)583296807 (DE-576)301028303 aut Hossfeld, Dieter K. 1938- verfasserin (DE-588)1055746471 (DE-627)793793335 (DE-576)411243020 aut Nerl, Christoph verfasserin aut Gratwohl, Alois 1947- verfasserin (DE-588)1089795653 (DE-627)853608105 (DE-576)460543067 aut Baerlocher, Gabriela M. verfasserin (DE-588)1112050051 (DE-627)866036784 (DE-576)47634803X aut Burchert, Andreas 1969- verfasserin (DE-588)120512874 (DE-627)696741482 (DE-576)292257392 aut Brümmendorf, Tim Henrik 1966- verfasserin (DE-588)115060219 (DE-627)47758148X (DE-576)289817625 aut Hasford, Jörg verfasserin aut Hochhaus, Andreas 1959- verfasserin (DE-588)1107039339 (DE-627)863321976 (DE-576)474976130 aut Saußele, Susanne 1968- verfasserin (DE-588)115839860 (DE-627)69162786X (DE-576)29010694X aut Baccarani, Michele 1942-2021 verfasserin (DE-588)1160739870 (DE-627)1024168077 (DE-576)176845674 aut Enthalten in Leukemia London : Springer Nature, 1997 34(2020), 8, Seite 2074-2086 Online-Ressource (DE-627)32046699X (DE-600)2008023-2 (DE-576)094139733 1476-5551 nnns volume:34 year:2020 number:8 pages:2074-2086 extent:13 Ergänzung Hehlmann, Rüdiger, 1941 - Impact of emerging ACA on survival in chronic myeloid leukemia (CML) 2022 (DE-627)1854621807 https://doi.org/10.1038/s41375-020-0826-9 Resolving-System Verlag kostenfrei Volltext https://www.nature.com/articles/s41375-020-0826-9 Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 34 2020 8 2074-2086 13 2013 01 DE-16-250 4363660244 00 --%%-- --%%-- --%%-- --%%-- l01 08-08-23 2403 01 DE-LFER 4374539573 00 --%%-- --%%-- n --%%-- l01 12-09-23 2403 01 DE-LFER https://doi.org/10.1038/s41375-020-0826-9 2403 01 DE-LFER https://www.nature.com/articles/s41375-020-0826-9 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_26 2013 01 DE-16-250 03 s s_13 2013 01 DE-16-250 04 p (DE-627)1460943260 Hehlmann, Rüdiger 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)156983542X Voskanyan, Astghik 2013 01 DE-16-250 05 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1505256119 Rinaldetti, Sébastien 2013 01 DE-16-250 06 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_6 2013 01 DE-16-250 07 p (DE-627)1576728684 Kohlbrenner, Katharina 2013 01 DE-16-250 07 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_7 2013 01 DE-16-250 08 p (DE-627)1460939530 Fabarius, Alice 2013 01 DE-16-250 08 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_10 2013 01 DE-16-250 09 p (DE-627)1463989180 Seifarth, Wolfgang 2013 01 DE-16-250 09 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_11 2013 01 DE-16-250 10 p (DE-627)1445787911 Spiess, Birgit 2013 01 DE-16-250 10 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 10 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 10 s pos_12 2013 01 DE-16-250 11 p (DE-627)1447988639 Wuchter, Patrick 2013 01 DE-16-250 11 k (DE-627)1416469052 Institut für Transfusionsmedizin und Immunologie 2013 01 DE-16-250 11 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 11 s pos_13 2013 01 DE-16-250 12 p (DE-627)145195381X Saußele, Susanne 2013 01 DE-16-250 12 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 12 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 12 s pos_25 |
| spelling |
10.1038/s41375-020-0826-9 doi (DE-627)1854628607 (DE-599)KXP1854628607 (OCoLC)1425217961 DE-627 ger DE-627 rda eng Hehlmann, Rüdiger 1941- verfasserin (DE-588)1037003489 (DE-627)751737879 (DE-576)390939463 aut High-risk additional chromosomal abnormalities at low blast counts herald death by CML Rüdiger Hehlmann, Astghik Voskanyan, Michael Lauseker, Markus Pfirrmann, Lida Kalmanti, Sebastien Rinaldetti, Katharina Kohlbrenner, Claudia Haferlach, Brigitte Schlegelberger, Alice Fabarius, Wolfgang Seifarth, Birgit Spieß, Patrick Wuchter, Stefan Krause, Hans-Jochem Kolb, Andreas Neubauer, Dieter K. Hossfeld, Christoph Nerl, Alois Gratwohl, Gabriela M. Baerlocher, Andreas Burchert, Tim H. Brümmendorf, Jörg Hasford, Andreas Hochhaus, Susanne Saußele, Michele Baccarani for the SAKK and the German CML Study Group 07 May 2020 13 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 08.08.2023 Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a timelier change of treatment is unknown. One thousand five hundred and ten imatinib-treated patients with Philadelphia-chromosome-positive (Ph+) CML randomized in CML-study IV were analyzed for ACA/Ph+ and blast increase. By impact on survival, ACAs were grouped into high risk (+8, +Ph, i(17q), +17, +19, +21, 3q26.2, 11q23, −7/7q abnormalities; complex) and low risk (all other). The presence of high- and low-risk ACAs was linked to six cohorts with different blast levels (1%, 5%, 10%, 15%, 20%, and 30%) in a Cox model. One hundred and twenty-three patients displayed ACA/Ph+ (8.1%), 91 were high risk. At low blast levels (1-15%), high-risk ACA showed an increased hazard to die compared to no ACA (ratios: 3.65 in blood; 6.12 in marrow) in contrast to low-risk ACA. No effect was observed at blast levels of 20-30%. Sixty-three patients with high-risk ACA (69%) died (n = 37) or were alive after progression or progression-related transplantation (n = 26). High-risk ACA at low blast counts identify end-phase CML earlier than current diagnostic systems. Mortality was lower with earlier treatment. Cytogenetic monitoring is indicated when signs of progression surface or response to therapy is unsatisfactory. Genetics research Translational research Voskanyan, Astghik 1973- verfasserin (DE-588)1152344005 (DE-627)1013874706 (DE-576)499833732 aut Lauseker, Michael 1981- verfasserin (DE-588)1058710265 (DE-627)79743223X (DE-576)414848438 aut Pfirrmann, Markus 1967- verfasserin (DE-588)133124932 (DE-627)534963617 (DE-576)299639835 aut Kalmanti, Lida verfasserin (DE-588)1067216995 (DE-627)818440961 (DE-576)426472586 aut Rinaldetti, Sébastien 1988- verfasserin (DE-588)1073669157 (DE-627)829329730 (DE-576)435254952 aut Kohlbrenner, Katharina 1970- verfasserin (DE-588)128734647 (DE-627)378683772 (DE-576)297304968 aut Haferlach, Claudia verfasserin (DE-588)1206213272 (DE-627)1691999199 aut Schlegelberger, Brigitte 1956- verfasserin (DE-588)133666115 (DE-627)550183779 (DE-576)30001029X aut Fabarius, Alice 1965- verfasserin (DE-588)1037001281 (DE-627)751728314 (DE-576)390896667 aut Seifarth, Wolfgang 1960- verfasserin (DE-588)1042491887 (DE-627)769066453 (DE-576)393988899 aut Spiess, Birgit 1972- verfasserin (DE-588)1028287496 (DE-627)730538699 (DE-576)37578764X aut Wuchter, Patrick 1975- verfasserin (DE-588)123450284 (DE-627)082563624 (DE-576)184642574 aut Krause, Stefan verfasserin aut Kolb, Hans-Jochem 1944- verfasserin (DE-588)133476219 (DE-627)691487162 (DE-576)299873625 aut Neubauer, Andreas 1958- verfasserin (DE-588)136452981 (DE-627)583296807 (DE-576)301028303 aut Hossfeld, Dieter K. 1938- verfasserin (DE-588)1055746471 (DE-627)793793335 (DE-576)411243020 aut Nerl, Christoph verfasserin aut Gratwohl, Alois 1947- verfasserin (DE-588)1089795653 (DE-627)853608105 (DE-576)460543067 aut Baerlocher, Gabriela M. verfasserin (DE-588)1112050051 (DE-627)866036784 (DE-576)47634803X aut Burchert, Andreas 1969- verfasserin (DE-588)120512874 (DE-627)696741482 (DE-576)292257392 aut Brümmendorf, Tim Henrik 1966- verfasserin (DE-588)115060219 (DE-627)47758148X (DE-576)289817625 aut Hasford, Jörg verfasserin aut Hochhaus, Andreas 1959- verfasserin (DE-588)1107039339 (DE-627)863321976 (DE-576)474976130 aut Saußele, Susanne 1968- verfasserin (DE-588)115839860 (DE-627)69162786X (DE-576)29010694X aut Baccarani, Michele 1942-2021 verfasserin (DE-588)1160739870 (DE-627)1024168077 (DE-576)176845674 aut Enthalten in Leukemia London : Springer Nature, 1997 34(2020), 8, Seite 2074-2086 Online-Ressource (DE-627)32046699X (DE-600)2008023-2 (DE-576)094139733 1476-5551 nnns volume:34 year:2020 number:8 pages:2074-2086 extent:13 Ergänzung Hehlmann, Rüdiger, 1941 - Impact of emerging ACA on survival in chronic myeloid leukemia (CML) 2022 (DE-627)1854621807 https://doi.org/10.1038/s41375-020-0826-9 Resolving-System Verlag kostenfrei Volltext https://www.nature.com/articles/s41375-020-0826-9 Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 34 2020 8 2074-2086 13 2013 01 DE-16-250 4363660244 00 --%%-- --%%-- --%%-- --%%-- l01 08-08-23 2403 01 DE-LFER 4374539573 00 --%%-- --%%-- n --%%-- l01 12-09-23 2403 01 DE-LFER https://doi.org/10.1038/s41375-020-0826-9 2403 01 DE-LFER https://www.nature.com/articles/s41375-020-0826-9 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_26 2013 01 DE-16-250 03 s s_13 2013 01 DE-16-250 04 p (DE-627)1460943260 Hehlmann, Rüdiger 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)156983542X Voskanyan, Astghik 2013 01 DE-16-250 05 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1505256119 Rinaldetti, Sébastien 2013 01 DE-16-250 06 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_6 2013 01 DE-16-250 07 p (DE-627)1576728684 Kohlbrenner, Katharina 2013 01 DE-16-250 07 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_7 2013 01 DE-16-250 08 p (DE-627)1460939530 Fabarius, Alice 2013 01 DE-16-250 08 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_10 2013 01 DE-16-250 09 p (DE-627)1463989180 Seifarth, Wolfgang 2013 01 DE-16-250 09 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_11 2013 01 DE-16-250 10 p (DE-627)1445787911 Spiess, Birgit 2013 01 DE-16-250 10 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 10 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 10 s pos_12 2013 01 DE-16-250 11 p (DE-627)1447988639 Wuchter, Patrick 2013 01 DE-16-250 11 k (DE-627)1416469052 Institut für Transfusionsmedizin und Immunologie 2013 01 DE-16-250 11 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 11 s pos_13 2013 01 DE-16-250 12 p (DE-627)145195381X Saußele, Susanne 2013 01 DE-16-250 12 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 12 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 12 s pos_25 |
| allfields_unstemmed |
10.1038/s41375-020-0826-9 doi (DE-627)1854628607 (DE-599)KXP1854628607 (OCoLC)1425217961 DE-627 ger DE-627 rda eng Hehlmann, Rüdiger 1941- verfasserin (DE-588)1037003489 (DE-627)751737879 (DE-576)390939463 aut High-risk additional chromosomal abnormalities at low blast counts herald death by CML Rüdiger Hehlmann, Astghik Voskanyan, Michael Lauseker, Markus Pfirrmann, Lida Kalmanti, Sebastien Rinaldetti, Katharina Kohlbrenner, Claudia Haferlach, Brigitte Schlegelberger, Alice Fabarius, Wolfgang Seifarth, Birgit Spieß, Patrick Wuchter, Stefan Krause, Hans-Jochem Kolb, Andreas Neubauer, Dieter K. Hossfeld, Christoph Nerl, Alois Gratwohl, Gabriela M. Baerlocher, Andreas Burchert, Tim H. Brümmendorf, Jörg Hasford, Andreas Hochhaus, Susanne Saußele, Michele Baccarani for the SAKK and the German CML Study Group 07 May 2020 13 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 08.08.2023 Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a timelier change of treatment is unknown. One thousand five hundred and ten imatinib-treated patients with Philadelphia-chromosome-positive (Ph+) CML randomized in CML-study IV were analyzed for ACA/Ph+ and blast increase. By impact on survival, ACAs were grouped into high risk (+8, +Ph, i(17q), +17, +19, +21, 3q26.2, 11q23, −7/7q abnormalities; complex) and low risk (all other). The presence of high- and low-risk ACAs was linked to six cohorts with different blast levels (1%, 5%, 10%, 15%, 20%, and 30%) in a Cox model. One hundred and twenty-three patients displayed ACA/Ph+ (8.1%), 91 were high risk. At low blast levels (1-15%), high-risk ACA showed an increased hazard to die compared to no ACA (ratios: 3.65 in blood; 6.12 in marrow) in contrast to low-risk ACA. No effect was observed at blast levels of 20-30%. Sixty-three patients with high-risk ACA (69%) died (n = 37) or were alive after progression or progression-related transplantation (n = 26). High-risk ACA at low blast counts identify end-phase CML earlier than current diagnostic systems. Mortality was lower with earlier treatment. Cytogenetic monitoring is indicated when signs of progression surface or response to therapy is unsatisfactory. Genetics research Translational research Voskanyan, Astghik 1973- verfasserin (DE-588)1152344005 (DE-627)1013874706 (DE-576)499833732 aut Lauseker, Michael 1981- verfasserin (DE-588)1058710265 (DE-627)79743223X (DE-576)414848438 aut Pfirrmann, Markus 1967- verfasserin (DE-588)133124932 (DE-627)534963617 (DE-576)299639835 aut Kalmanti, Lida verfasserin (DE-588)1067216995 (DE-627)818440961 (DE-576)426472586 aut Rinaldetti, Sébastien 1988- verfasserin (DE-588)1073669157 (DE-627)829329730 (DE-576)435254952 aut Kohlbrenner, Katharina 1970- verfasserin (DE-588)128734647 (DE-627)378683772 (DE-576)297304968 aut Haferlach, Claudia verfasserin (DE-588)1206213272 (DE-627)1691999199 aut Schlegelberger, Brigitte 1956- verfasserin (DE-588)133666115 (DE-627)550183779 (DE-576)30001029X aut Fabarius, Alice 1965- verfasserin (DE-588)1037001281 (DE-627)751728314 (DE-576)390896667 aut Seifarth, Wolfgang 1960- verfasserin (DE-588)1042491887 (DE-627)769066453 (DE-576)393988899 aut Spiess, Birgit 1972- verfasserin (DE-588)1028287496 (DE-627)730538699 (DE-576)37578764X aut Wuchter, Patrick 1975- verfasserin (DE-588)123450284 (DE-627)082563624 (DE-576)184642574 aut Krause, Stefan verfasserin aut Kolb, Hans-Jochem 1944- verfasserin (DE-588)133476219 (DE-627)691487162 (DE-576)299873625 aut Neubauer, Andreas 1958- verfasserin (DE-588)136452981 (DE-627)583296807 (DE-576)301028303 aut Hossfeld, Dieter K. 1938- verfasserin (DE-588)1055746471 (DE-627)793793335 (DE-576)411243020 aut Nerl, Christoph verfasserin aut Gratwohl, Alois 1947- verfasserin (DE-588)1089795653 (DE-627)853608105 (DE-576)460543067 aut Baerlocher, Gabriela M. verfasserin (DE-588)1112050051 (DE-627)866036784 (DE-576)47634803X aut Burchert, Andreas 1969- verfasserin (DE-588)120512874 (DE-627)696741482 (DE-576)292257392 aut Brümmendorf, Tim Henrik 1966- verfasserin (DE-588)115060219 (DE-627)47758148X (DE-576)289817625 aut Hasford, Jörg verfasserin aut Hochhaus, Andreas 1959- verfasserin (DE-588)1107039339 (DE-627)863321976 (DE-576)474976130 aut Saußele, Susanne 1968- verfasserin (DE-588)115839860 (DE-627)69162786X (DE-576)29010694X aut Baccarani, Michele 1942-2021 verfasserin (DE-588)1160739870 (DE-627)1024168077 (DE-576)176845674 aut Enthalten in Leukemia London : Springer Nature, 1997 34(2020), 8, Seite 2074-2086 Online-Ressource (DE-627)32046699X (DE-600)2008023-2 (DE-576)094139733 1476-5551 nnns volume:34 year:2020 number:8 pages:2074-2086 extent:13 Ergänzung Hehlmann, Rüdiger, 1941 - Impact of emerging ACA on survival in chronic myeloid leukemia (CML) 2022 (DE-627)1854621807 https://doi.org/10.1038/s41375-020-0826-9 Resolving-System Verlag kostenfrei Volltext https://www.nature.com/articles/s41375-020-0826-9 Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 34 2020 8 2074-2086 13 2013 01 DE-16-250 4363660244 00 --%%-- --%%-- --%%-- --%%-- l01 08-08-23 2403 01 DE-LFER 4374539573 00 --%%-- --%%-- n --%%-- l01 12-09-23 2403 01 DE-LFER https://doi.org/10.1038/s41375-020-0826-9 2403 01 DE-LFER https://www.nature.com/articles/s41375-020-0826-9 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_26 2013 01 DE-16-250 03 s s_13 2013 01 DE-16-250 04 p (DE-627)1460943260 Hehlmann, Rüdiger 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)156983542X Voskanyan, Astghik 2013 01 DE-16-250 05 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1505256119 Rinaldetti, Sébastien 2013 01 DE-16-250 06 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_6 2013 01 DE-16-250 07 p (DE-627)1576728684 Kohlbrenner, Katharina 2013 01 DE-16-250 07 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_7 2013 01 DE-16-250 08 p (DE-627)1460939530 Fabarius, Alice 2013 01 DE-16-250 08 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_10 2013 01 DE-16-250 09 p (DE-627)1463989180 Seifarth, Wolfgang 2013 01 DE-16-250 09 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_11 2013 01 DE-16-250 10 p (DE-627)1445787911 Spiess, Birgit 2013 01 DE-16-250 10 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 10 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 10 s pos_12 2013 01 DE-16-250 11 p (DE-627)1447988639 Wuchter, Patrick 2013 01 DE-16-250 11 k (DE-627)1416469052 Institut für Transfusionsmedizin und Immunologie 2013 01 DE-16-250 11 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 11 s pos_13 2013 01 DE-16-250 12 p (DE-627)145195381X Saußele, Susanne 2013 01 DE-16-250 12 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 12 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 12 s pos_25 |
| allfieldsGer |
10.1038/s41375-020-0826-9 doi (DE-627)1854628607 (DE-599)KXP1854628607 (OCoLC)1425217961 DE-627 ger DE-627 rda eng Hehlmann, Rüdiger 1941- verfasserin (DE-588)1037003489 (DE-627)751737879 (DE-576)390939463 aut High-risk additional chromosomal abnormalities at low blast counts herald death by CML Rüdiger Hehlmann, Astghik Voskanyan, Michael Lauseker, Markus Pfirrmann, Lida Kalmanti, Sebastien Rinaldetti, Katharina Kohlbrenner, Claudia Haferlach, Brigitte Schlegelberger, Alice Fabarius, Wolfgang Seifarth, Birgit Spieß, Patrick Wuchter, Stefan Krause, Hans-Jochem Kolb, Andreas Neubauer, Dieter K. Hossfeld, Christoph Nerl, Alois Gratwohl, Gabriela M. Baerlocher, Andreas Burchert, Tim H. Brümmendorf, Jörg Hasford, Andreas Hochhaus, Susanne Saußele, Michele Baccarani for the SAKK and the German CML Study Group 07 May 2020 13 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 08.08.2023 Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a timelier change of treatment is unknown. One thousand five hundred and ten imatinib-treated patients with Philadelphia-chromosome-positive (Ph+) CML randomized in CML-study IV were analyzed for ACA/Ph+ and blast increase. By impact on survival, ACAs were grouped into high risk (+8, +Ph, i(17q), +17, +19, +21, 3q26.2, 11q23, −7/7q abnormalities; complex) and low risk (all other). The presence of high- and low-risk ACAs was linked to six cohorts with different blast levels (1%, 5%, 10%, 15%, 20%, and 30%) in a Cox model. One hundred and twenty-three patients displayed ACA/Ph+ (8.1%), 91 were high risk. At low blast levels (1-15%), high-risk ACA showed an increased hazard to die compared to no ACA (ratios: 3.65 in blood; 6.12 in marrow) in contrast to low-risk ACA. No effect was observed at blast levels of 20-30%. Sixty-three patients with high-risk ACA (69%) died (n = 37) or were alive after progression or progression-related transplantation (n = 26). High-risk ACA at low blast counts identify end-phase CML earlier than current diagnostic systems. Mortality was lower with earlier treatment. Cytogenetic monitoring is indicated when signs of progression surface or response to therapy is unsatisfactory. Genetics research Translational research Voskanyan, Astghik 1973- verfasserin (DE-588)1152344005 (DE-627)1013874706 (DE-576)499833732 aut Lauseker, Michael 1981- verfasserin (DE-588)1058710265 (DE-627)79743223X (DE-576)414848438 aut Pfirrmann, Markus 1967- verfasserin (DE-588)133124932 (DE-627)534963617 (DE-576)299639835 aut Kalmanti, Lida verfasserin (DE-588)1067216995 (DE-627)818440961 (DE-576)426472586 aut Rinaldetti, Sébastien 1988- verfasserin (DE-588)1073669157 (DE-627)829329730 (DE-576)435254952 aut Kohlbrenner, Katharina 1970- verfasserin (DE-588)128734647 (DE-627)378683772 (DE-576)297304968 aut Haferlach, Claudia verfasserin (DE-588)1206213272 (DE-627)1691999199 aut Schlegelberger, Brigitte 1956- verfasserin (DE-588)133666115 (DE-627)550183779 (DE-576)30001029X aut Fabarius, Alice 1965- verfasserin (DE-588)1037001281 (DE-627)751728314 (DE-576)390896667 aut Seifarth, Wolfgang 1960- verfasserin (DE-588)1042491887 (DE-627)769066453 (DE-576)393988899 aut Spiess, Birgit 1972- verfasserin (DE-588)1028287496 (DE-627)730538699 (DE-576)37578764X aut Wuchter, Patrick 1975- verfasserin (DE-588)123450284 (DE-627)082563624 (DE-576)184642574 aut Krause, Stefan verfasserin aut Kolb, Hans-Jochem 1944- verfasserin (DE-588)133476219 (DE-627)691487162 (DE-576)299873625 aut Neubauer, Andreas 1958- verfasserin (DE-588)136452981 (DE-627)583296807 (DE-576)301028303 aut Hossfeld, Dieter K. 1938- verfasserin (DE-588)1055746471 (DE-627)793793335 (DE-576)411243020 aut Nerl, Christoph verfasserin aut Gratwohl, Alois 1947- verfasserin (DE-588)1089795653 (DE-627)853608105 (DE-576)460543067 aut Baerlocher, Gabriela M. verfasserin (DE-588)1112050051 (DE-627)866036784 (DE-576)47634803X aut Burchert, Andreas 1969- verfasserin (DE-588)120512874 (DE-627)696741482 (DE-576)292257392 aut Brümmendorf, Tim Henrik 1966- verfasserin (DE-588)115060219 (DE-627)47758148X (DE-576)289817625 aut Hasford, Jörg verfasserin aut Hochhaus, Andreas 1959- verfasserin (DE-588)1107039339 (DE-627)863321976 (DE-576)474976130 aut Saußele, Susanne 1968- verfasserin (DE-588)115839860 (DE-627)69162786X (DE-576)29010694X aut Baccarani, Michele 1942-2021 verfasserin (DE-588)1160739870 (DE-627)1024168077 (DE-576)176845674 aut Enthalten in Leukemia London : Springer Nature, 1997 34(2020), 8, Seite 2074-2086 Online-Ressource (DE-627)32046699X (DE-600)2008023-2 (DE-576)094139733 1476-5551 nnns volume:34 year:2020 number:8 pages:2074-2086 extent:13 Ergänzung Hehlmann, Rüdiger, 1941 - Impact of emerging ACA on survival in chronic myeloid leukemia (CML) 2022 (DE-627)1854621807 https://doi.org/10.1038/s41375-020-0826-9 Resolving-System Verlag kostenfrei Volltext https://www.nature.com/articles/s41375-020-0826-9 Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 34 2020 8 2074-2086 13 2013 01 DE-16-250 4363660244 00 --%%-- --%%-- --%%-- --%%-- l01 08-08-23 2403 01 DE-LFER 4374539573 00 --%%-- --%%-- n --%%-- l01 12-09-23 2403 01 DE-LFER https://doi.org/10.1038/s41375-020-0826-9 2403 01 DE-LFER https://www.nature.com/articles/s41375-020-0826-9 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_26 2013 01 DE-16-250 03 s s_13 2013 01 DE-16-250 04 p (DE-627)1460943260 Hehlmann, Rüdiger 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)156983542X Voskanyan, Astghik 2013 01 DE-16-250 05 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1505256119 Rinaldetti, Sébastien 2013 01 DE-16-250 06 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_6 2013 01 DE-16-250 07 p (DE-627)1576728684 Kohlbrenner, Katharina 2013 01 DE-16-250 07 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_7 2013 01 DE-16-250 08 p (DE-627)1460939530 Fabarius, Alice 2013 01 DE-16-250 08 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_10 2013 01 DE-16-250 09 p (DE-627)1463989180 Seifarth, Wolfgang 2013 01 DE-16-250 09 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_11 2013 01 DE-16-250 10 p (DE-627)1445787911 Spiess, Birgit 2013 01 DE-16-250 10 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 10 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 10 s pos_12 2013 01 DE-16-250 11 p (DE-627)1447988639 Wuchter, Patrick 2013 01 DE-16-250 11 k (DE-627)1416469052 Institut für Transfusionsmedizin und Immunologie 2013 01 DE-16-250 11 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 11 s pos_13 2013 01 DE-16-250 12 p (DE-627)145195381X Saußele, Susanne 2013 01 DE-16-250 12 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 12 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 12 s pos_25 |
| allfieldsSound |
10.1038/s41375-020-0826-9 doi (DE-627)1854628607 (DE-599)KXP1854628607 (OCoLC)1425217961 DE-627 ger DE-627 rda eng Hehlmann, Rüdiger 1941- verfasserin (DE-588)1037003489 (DE-627)751737879 (DE-576)390939463 aut High-risk additional chromosomal abnormalities at low blast counts herald death by CML Rüdiger Hehlmann, Astghik Voskanyan, Michael Lauseker, Markus Pfirrmann, Lida Kalmanti, Sebastien Rinaldetti, Katharina Kohlbrenner, Claudia Haferlach, Brigitte Schlegelberger, Alice Fabarius, Wolfgang Seifarth, Birgit Spieß, Patrick Wuchter, Stefan Krause, Hans-Jochem Kolb, Andreas Neubauer, Dieter K. Hossfeld, Christoph Nerl, Alois Gratwohl, Gabriela M. Baerlocher, Andreas Burchert, Tim H. Brümmendorf, Jörg Hasford, Andreas Hochhaus, Susanne Saußele, Michele Baccarani for the SAKK and the German CML Study Group 07 May 2020 13 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 08.08.2023 Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a timelier change of treatment is unknown. One thousand five hundred and ten imatinib-treated patients with Philadelphia-chromosome-positive (Ph+) CML randomized in CML-study IV were analyzed for ACA/Ph+ and blast increase. By impact on survival, ACAs were grouped into high risk (+8, +Ph, i(17q), +17, +19, +21, 3q26.2, 11q23, −7/7q abnormalities; complex) and low risk (all other). The presence of high- and low-risk ACAs was linked to six cohorts with different blast levels (1%, 5%, 10%, 15%, 20%, and 30%) in a Cox model. One hundred and twenty-three patients displayed ACA/Ph+ (8.1%), 91 were high risk. At low blast levels (1-15%), high-risk ACA showed an increased hazard to die compared to no ACA (ratios: 3.65 in blood; 6.12 in marrow) in contrast to low-risk ACA. No effect was observed at blast levels of 20-30%. Sixty-three patients with high-risk ACA (69%) died (n = 37) or were alive after progression or progression-related transplantation (n = 26). High-risk ACA at low blast counts identify end-phase CML earlier than current diagnostic systems. Mortality was lower with earlier treatment. Cytogenetic monitoring is indicated when signs of progression surface or response to therapy is unsatisfactory. Genetics research Translational research Voskanyan, Astghik 1973- verfasserin (DE-588)1152344005 (DE-627)1013874706 (DE-576)499833732 aut Lauseker, Michael 1981- verfasserin (DE-588)1058710265 (DE-627)79743223X (DE-576)414848438 aut Pfirrmann, Markus 1967- verfasserin (DE-588)133124932 (DE-627)534963617 (DE-576)299639835 aut Kalmanti, Lida verfasserin (DE-588)1067216995 (DE-627)818440961 (DE-576)426472586 aut Rinaldetti, Sébastien 1988- verfasserin (DE-588)1073669157 (DE-627)829329730 (DE-576)435254952 aut Kohlbrenner, Katharina 1970- verfasserin (DE-588)128734647 (DE-627)378683772 (DE-576)297304968 aut Haferlach, Claudia verfasserin (DE-588)1206213272 (DE-627)1691999199 aut Schlegelberger, Brigitte 1956- verfasserin (DE-588)133666115 (DE-627)550183779 (DE-576)30001029X aut Fabarius, Alice 1965- verfasserin (DE-588)1037001281 (DE-627)751728314 (DE-576)390896667 aut Seifarth, Wolfgang 1960- verfasserin (DE-588)1042491887 (DE-627)769066453 (DE-576)393988899 aut Spiess, Birgit 1972- verfasserin (DE-588)1028287496 (DE-627)730538699 (DE-576)37578764X aut Wuchter, Patrick 1975- verfasserin (DE-588)123450284 (DE-627)082563624 (DE-576)184642574 aut Krause, Stefan verfasserin aut Kolb, Hans-Jochem 1944- verfasserin (DE-588)133476219 (DE-627)691487162 (DE-576)299873625 aut Neubauer, Andreas 1958- verfasserin (DE-588)136452981 (DE-627)583296807 (DE-576)301028303 aut Hossfeld, Dieter K. 1938- verfasserin (DE-588)1055746471 (DE-627)793793335 (DE-576)411243020 aut Nerl, Christoph verfasserin aut Gratwohl, Alois 1947- verfasserin (DE-588)1089795653 (DE-627)853608105 (DE-576)460543067 aut Baerlocher, Gabriela M. verfasserin (DE-588)1112050051 (DE-627)866036784 (DE-576)47634803X aut Burchert, Andreas 1969- verfasserin (DE-588)120512874 (DE-627)696741482 (DE-576)292257392 aut Brümmendorf, Tim Henrik 1966- verfasserin (DE-588)115060219 (DE-627)47758148X (DE-576)289817625 aut Hasford, Jörg verfasserin aut Hochhaus, Andreas 1959- verfasserin (DE-588)1107039339 (DE-627)863321976 (DE-576)474976130 aut Saußele, Susanne 1968- verfasserin (DE-588)115839860 (DE-627)69162786X (DE-576)29010694X aut Baccarani, Michele 1942-2021 verfasserin (DE-588)1160739870 (DE-627)1024168077 (DE-576)176845674 aut Enthalten in Leukemia London : Springer Nature, 1997 34(2020), 8, Seite 2074-2086 Online-Ressource (DE-627)32046699X (DE-600)2008023-2 (DE-576)094139733 1476-5551 nnns volume:34 year:2020 number:8 pages:2074-2086 extent:13 Ergänzung Hehlmann, Rüdiger, 1941 - Impact of emerging ACA on survival in chronic myeloid leukemia (CML) 2022 (DE-627)1854621807 https://doi.org/10.1038/s41375-020-0826-9 Resolving-System Verlag kostenfrei Volltext https://www.nature.com/articles/s41375-020-0826-9 Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 34 2020 8 2074-2086 13 2013 01 DE-16-250 4363660244 00 --%%-- --%%-- --%%-- --%%-- l01 08-08-23 2403 01 DE-LFER 4374539573 00 --%%-- --%%-- n --%%-- l01 12-09-23 2403 01 DE-LFER https://doi.org/10.1038/s41375-020-0826-9 2403 01 DE-LFER https://www.nature.com/articles/s41375-020-0826-9 2013 01 DE-16-250 00 s hd2020 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_26 2013 01 DE-16-250 03 s s_13 2013 01 DE-16-250 04 p (DE-627)1460943260 Hehlmann, Rüdiger 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)156983542X Voskanyan, Astghik 2013 01 DE-16-250 05 k (DE-627)1416468528 III. 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misc Genetics research misc Translational research 2013 hd2020 2013 wissenschaftlicher Artikel (Zeitschrift) 2013 per_26 2013 s_13 2013 Hehlmann, Rüdiger 2013 Medizinische Fakultät Mannheim 2013 Verfasser 2013 pos_1 2013 Voskanyan, Astghik 2013 III. Medizinische Klinik 2013 pos_2 2013 Rinaldetti, Sébastien 2013 pos_6 2013 Kohlbrenner, Katharina 2013 pos_7 2013 Fabarius, Alice 2013 pos_10 2013 Seifarth, Wolfgang 2013 pos_11 2013 Spiess, Birgit 2013 pos_12 2013 Wuchter, Patrick 2013 Institut für Transfusionsmedizin und Immunologie 2013 pos_13 2013 Saußele, Susanne 2013 pos_25 |
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High-risk additional chromosomal abnormalities at low blast counts herald death by CML Rüdiger Hehlmann, Astghik Voskanyan, Michael Lauseker, Markus Pfirrmann, Lida Kalmanti, Sebastien Rinaldetti, Katharina Kohlbrenner, Claudia Haferlach, Brigitte Schlegelberger, Alice Fabarius, Wolfgang Seifarth, Birgit Spieß, Patrick Wuchter, Stefan Krause, Hans-Jochem Kolb, Andreas Neubauer, Dieter K. Hossfeld, Christoph Nerl, Alois Gratwohl, Gabriela M. Baerlocher, Andreas Burchert, Tim H. Brümmendorf, Jörg Hasford, Andreas Hochhaus, Susanne Saußele, Michele Baccarani for the SAKK and the German CML Study Group |
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high-risk additional chromosomal abnormalities at low blast counts herald death by cml |
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High-risk additional chromosomal abnormalities at low blast counts herald death by CML |
| abstract |
Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a timelier change of treatment is unknown. One thousand five hundred and ten imatinib-treated patients with Philadelphia-chromosome-positive (Ph+) CML randomized in CML-study IV were analyzed for ACA/Ph+ and blast increase. By impact on survival, ACAs were grouped into high risk (+8, +Ph, i(17q), +17, +19, +21, 3q26.2, 11q23, −7/7q abnormalities; complex) and low risk (all other). The presence of high- and low-risk ACAs was linked to six cohorts with different blast levels (1%, 5%, 10%, 15%, 20%, and 30%) in a Cox model. One hundred and twenty-three patients displayed ACA/Ph+ (8.1%), 91 were high risk. At low blast levels (1-15%), high-risk ACA showed an increased hazard to die compared to no ACA (ratios: 3.65 in blood; 6.12 in marrow) in contrast to low-risk ACA. No effect was observed at blast levels of 20-30%. Sixty-three patients with high-risk ACA (69%) died (n = 37) or were alive after progression or progression-related transplantation (n = 26). High-risk ACA at low blast counts identify end-phase CML earlier than current diagnostic systems. Mortality was lower with earlier treatment. Cytogenetic monitoring is indicated when signs of progression surface or response to therapy is unsatisfactory. Gesehen am 08.08.2023 Impact of emerging ACA on survival in chronic myeloid leukemia (CML) |
| abstractGer |
Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a timelier change of treatment is unknown. One thousand five hundred and ten imatinib-treated patients with Philadelphia-chromosome-positive (Ph+) CML randomized in CML-study IV were analyzed for ACA/Ph+ and blast increase. By impact on survival, ACAs were grouped into high risk (+8, +Ph, i(17q), +17, +19, +21, 3q26.2, 11q23, −7/7q abnormalities; complex) and low risk (all other). The presence of high- and low-risk ACAs was linked to six cohorts with different blast levels (1%, 5%, 10%, 15%, 20%, and 30%) in a Cox model. One hundred and twenty-three patients displayed ACA/Ph+ (8.1%), 91 were high risk. At low blast levels (1-15%), high-risk ACA showed an increased hazard to die compared to no ACA (ratios: 3.65 in blood; 6.12 in marrow) in contrast to low-risk ACA. No effect was observed at blast levels of 20-30%. Sixty-three patients with high-risk ACA (69%) died (n = 37) or were alive after progression or progression-related transplantation (n = 26). High-risk ACA at low blast counts identify end-phase CML earlier than current diagnostic systems. Mortality was lower with earlier treatment. Cytogenetic monitoring is indicated when signs of progression surface or response to therapy is unsatisfactory. Gesehen am 08.08.2023 Impact of emerging ACA on survival in chronic myeloid leukemia (CML) |
| abstract_unstemmed |
Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a timelier change of treatment is unknown. One thousand five hundred and ten imatinib-treated patients with Philadelphia-chromosome-positive (Ph+) CML randomized in CML-study IV were analyzed for ACA/Ph+ and blast increase. By impact on survival, ACAs were grouped into high risk (+8, +Ph, i(17q), +17, +19, +21, 3q26.2, 11q23, −7/7q abnormalities; complex) and low risk (all other). The presence of high- and low-risk ACAs was linked to six cohorts with different blast levels (1%, 5%, 10%, 15%, 20%, and 30%) in a Cox model. One hundred and twenty-three patients displayed ACA/Ph+ (8.1%), 91 were high risk. At low blast levels (1-15%), high-risk ACA showed an increased hazard to die compared to no ACA (ratios: 3.65 in blood; 6.12 in marrow) in contrast to low-risk ACA. No effect was observed at blast levels of 20-30%. Sixty-three patients with high-risk ACA (69%) died (n = 37) or were alive after progression or progression-related transplantation (n = 26). High-risk ACA at low blast counts identify end-phase CML earlier than current diagnostic systems. Mortality was lower with earlier treatment. Cytogenetic monitoring is indicated when signs of progression surface or response to therapy is unsatisfactory. Gesehen am 08.08.2023 Impact of emerging ACA on survival in chronic myeloid leukemia (CML) |
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High-risk additional chromosomal abnormalities at low blast counts herald death by CML |
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https://doi.org/10.1038/s41375-020-0826-9 https://www.nature.com/articles/s41375-020-0826-9 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">1854628607</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240307094506.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230808s2020 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1038/s41375-020-0826-9</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)1854628607</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)KXP1854628607</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1425217961</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Hehlmann, Rüdiger</subfield><subfield code="d">1941-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)1037003489</subfield><subfield code="0">(DE-627)751737879</subfield><subfield code="0">(DE-576)390939463</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">High-risk additional chromosomal abnormalities at low blast counts herald death by CML</subfield><subfield code="c">Rüdiger Hehlmann, Astghik Voskanyan, Michael Lauseker, Markus Pfirrmann, Lida Kalmanti, Sebastien Rinaldetti, Katharina Kohlbrenner, Claudia Haferlach, Brigitte Schlegelberger, Alice Fabarius, Wolfgang Seifarth, Birgit Spieß, Patrick Wuchter, Stefan Krause, Hans-Jochem Kolb, Andreas Neubauer, Dieter K. Hossfeld, Christoph Nerl, Alois Gratwohl, Gabriela M. Baerlocher, Andreas Burchert, Tim H. Brümmendorf, Jörg Hasford, Andreas Hochhaus, Susanne Saußele, Michele Baccarani for the SAKK and the German CML Study Group</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">07 May 2020</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">13</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Gesehen am 08.08.2023</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a timelier change of treatment is unknown. One thousand five hundred and ten imatinib-treated patients with Philadelphia-chromosome-positive (Ph+) CML randomized in CML-study IV were analyzed for ACA/Ph+ and blast increase. By impact on survival, ACAs were grouped into high risk (+8, +Ph, i(17q), +17, +19, +21, 3q26.2, 11q23, −7/7q abnormalities; complex) and low risk (all other). The presence of high- and low-risk ACAs was linked to six cohorts with different blast levels (1%, 5%, 10%, 15%, 20%, and 30%) in a Cox model. One hundred and twenty-three patients displayed ACA/Ph+ (8.1%), 91 were high risk. At low blast levels (1-15%), high-risk ACA showed an increased hazard to die compared to no ACA (ratios: 3.65 in blood; 6.12 in marrow) in contrast to low-risk ACA. No effect was observed at blast levels of 20-30%. Sixty-three patients with high-risk ACA (69%) died (n = 37) or were alive after progression or progression-related transplantation (n = 26). High-risk ACA at low blast counts identify end-phase CML earlier than current diagnostic systems. Mortality was lower with earlier treatment. Cytogenetic monitoring is indicated when signs of progression surface or response to therapy is unsatisfactory.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Genetics research</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Translational research</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Voskanyan, Astghik</subfield><subfield code="d">1973-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)1152344005</subfield><subfield code="0">(DE-627)1013874706</subfield><subfield code="0">(DE-576)499833732</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lauseker, Michael</subfield><subfield code="d">1981-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)1058710265</subfield><subfield code="0">(DE-627)79743223X</subfield><subfield code="0">(DE-576)414848438</subfield><subfield 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code="y">l01</subfield><subfield code="z">08-08-23</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2403</subfield><subfield code="1">01</subfield><subfield code="x">DE-LFER</subfield><subfield code="b">4374539573</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">n</subfield><subfield code="j">--%%--</subfield><subfield code="y">l01</subfield><subfield code="z">12-09-23</subfield></datafield><datafield tag="981" ind1=" " ind2=" "><subfield code="2">2403</subfield><subfield code="1">01</subfield><subfield code="x">DE-LFER</subfield><subfield code="r">https://doi.org/10.1038/s41375-020-0826-9</subfield></datafield><datafield tag="981" ind1=" " ind2=" "><subfield code="2">2403</subfield><subfield code="1">01</subfield><subfield code="x">DE-LFER</subfield><subfield code="r">https://www.nature.com/articles/s41375-020-0826-9</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">00</subfield><subfield code="s">s</subfield><subfield code="a">hd2020</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">01</subfield><subfield code="s">s</subfield><subfield code="0">(DE-627)1410508463</subfield><subfield code="a">wissenschaftlicher Artikel (Zeitschrift)</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">02</subfield><subfield code="s">s</subfield><subfield code="a">per_26</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">03</subfield><subfield code="s">s</subfield><subfield code="a">s_13</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">04</subfield><subfield code="s">p</subfield><subfield code="0">(DE-627)1460943260</subfield><subfield code="a">Hehlmann, Rüdiger</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">04</subfield><subfield code="s">k</subfield><subfield code="0">(DE-627)1416467254</subfield><subfield code="a">Medizinische Fakultät Mannheim</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">04</subfield><subfield code="s">s</subfield><subfield code="0">(DE-627)1410501914</subfield><subfield code="a">Verfasser</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">04</subfield><subfield code="s">s</subfield><subfield code="a">pos_1</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">05</subfield><subfield code="s">p</subfield><subfield code="0">(DE-627)156983542X</subfield><subfield code="a">Voskanyan, Astghik</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">05</subfield><subfield code="s">k</subfield><subfield code="0">(DE-627)1416468528</subfield><subfield code="a">III. Medizinische Klinik</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">05</subfield><subfield code="s">s</subfield><subfield code="0">(DE-627)1410501914</subfield><subfield code="a">Verfasser</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">05</subfield><subfield code="s">s</subfield><subfield code="a">pos_2</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">06</subfield><subfield code="s">p</subfield><subfield code="0">(DE-627)1505256119</subfield><subfield code="a">Rinaldetti, Sébastien</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">06</subfield><subfield code="s">k</subfield><subfield code="0">(DE-627)1416468528</subfield><subfield code="a">III. Medizinische Klinik</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">06</subfield><subfield code="s">s</subfield><subfield code="0">(DE-627)1410501914</subfield><subfield code="a">Verfasser</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">06</subfield><subfield code="s">s</subfield><subfield code="a">pos_6</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">07</subfield><subfield code="s">p</subfield><subfield code="0">(DE-627)1576728684</subfield><subfield code="a">Kohlbrenner, Katharina</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">07</subfield><subfield code="s">k</subfield><subfield code="0">(DE-627)1416468528</subfield><subfield code="a">III. Medizinische Klinik</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">07</subfield><subfield code="s">s</subfield><subfield code="0">(DE-627)1410501914</subfield><subfield code="a">Verfasser</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">07</subfield><subfield code="s">s</subfield><subfield code="a">pos_7</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">08</subfield><subfield code="s">p</subfield><subfield code="0">(DE-627)1460939530</subfield><subfield code="a">Fabarius, Alice</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">08</subfield><subfield code="s">k</subfield><subfield code="0">(DE-627)1416468528</subfield><subfield code="a">III. Medizinische Klinik</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">08</subfield><subfield code="s">s</subfield><subfield code="0">(DE-627)1410501914</subfield><subfield code="a">Verfasser</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">08</subfield><subfield code="s">s</subfield><subfield code="a">pos_10</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">09</subfield><subfield code="s">p</subfield><subfield code="0">(DE-627)1463989180</subfield><subfield code="a">Seifarth, Wolfgang</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">09</subfield><subfield code="s">k</subfield><subfield code="0">(DE-627)1416468528</subfield><subfield code="a">III. Medizinische Klinik</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">09</subfield><subfield code="s">s</subfield><subfield code="0">(DE-627)1410501914</subfield><subfield code="a">Verfasser</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">09</subfield><subfield code="s">s</subfield><subfield code="a">pos_11</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">10</subfield><subfield code="s">p</subfield><subfield code="0">(DE-627)1445787911</subfield><subfield code="a">Spiess, Birgit</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">10</subfield><subfield code="s">k</subfield><subfield code="0">(DE-627)1416468528</subfield><subfield code="a">III. Medizinische Klinik</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">10</subfield><subfield code="s">s</subfield><subfield code="0">(DE-627)1410501914</subfield><subfield code="a">Verfasser</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">10</subfield><subfield code="s">s</subfield><subfield code="a">pos_12</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">11</subfield><subfield code="s">p</subfield><subfield code="0">(DE-627)1447988639</subfield><subfield code="a">Wuchter, Patrick</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">11</subfield><subfield code="s">k</subfield><subfield code="0">(DE-627)1416469052</subfield><subfield code="a">Institut für Transfusionsmedizin und Immunologie</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">11</subfield><subfield code="s">s</subfield><subfield code="0">(DE-627)1410501914</subfield><subfield code="a">Verfasser</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">11</subfield><subfield code="s">s</subfield><subfield code="a">pos_13</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">12</subfield><subfield code="s">p</subfield><subfield code="0">(DE-627)145195381X</subfield><subfield code="a">Saußele, Susanne</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">12</subfield><subfield code="s">k</subfield><subfield code="0">(DE-627)1416468528</subfield><subfield code="a">III. Medizinische Klinik</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">12</subfield><subfield code="s">s</subfield><subfield code="0">(DE-627)1410501914</subfield><subfield code="a">Verfasser</subfield></datafield><datafield tag="982" ind1=" " ind2=" "><subfield code="2">2013</subfield><subfield code="1">01</subfield><subfield code="x">DE-16-250</subfield><subfield code="8">12</subfield><subfield code="s">s</subfield><subfield code="a">pos_25</subfield></datafield></record></collection>
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