Clinical practice recommendations for recurrence of focal and segmental glomerulosclerosis/steroid-resistant nephrotic syndrome
Recurrence of primary disease is one of the major risks for allograft loss after pediatric RTx. The risk of recurrence of FSGS/SRNS after pediatric RTx in particular can be up to 86% in idiopathic cases. There is a need for consensus recommendations on its prevention and treatment. The CERTAIN study...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Weber, Lutz T. - 1969- [verfasserIn] Tönshoff, Burkhard [verfasserIn] Grenda, Ryszard [verfasserIn] Bouts, Antonia [verfasserIn] Topaloglu, Rezan [verfasserIn] Gülhan, Bora [verfasserIn] Printza, Nikoleta [verfasserIn] Awan, Atif [verfasserIn] Battelino, Nina [verfasserIn] Ehren, Rasmus [verfasserIn] Hoyer, Peter F. [verfasserIn] Novljan, Gregor [verfasserIn] Marks, Stephen D. [verfasserIn] Oh, Jun [verfasserIn] Prytula, Agnieszka [verfasserIn] Seeman, Tomas [verfasserIn] Sweeney, Clodagh [verfasserIn] Dello Strologo, Luca [verfasserIn] Pape, Lars [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
Gesehen am 06.11.2023 |
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| Umfang: |
10 |
| Übergeordnetes Werk: |
Enthalten in: Pediatric transplantation - Oxford [u.a.] : Wiley-Blackwell, 1999, 25(2021), 3 vom: Mai, Artikel-ID e13955, Seite 1-10 |
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| Übergeordnetes Werk: |
volume:25 ; year:2021 ; number:3 ; month:05 ; elocationid:e13955 ; pages:1-10 ; extent:10 |
| Links: |
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| DOI / URN: |
10.1111/petr.13955 |
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| Katalog-ID: |
1869414691 |
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| 245 | 1 | 0 | |a Clinical practice recommendations for recurrence of focal and segmental glomerulosclerosis/steroid-resistant nephrotic syndrome |c Lutz T. Weber, Burkhard Tönshoff, Ryszard Grenda, Antonia Bouts, Rezan Topaloglu, Bora Gülhan, Nikoleta Printza, Atif Awan, Nina Battelino, Rasmus Ehren, Peter F. Hoyer, Gregor Novljan, Stephen D. Marks, Jun Oh, Agnieszka Prytula, Tomas Seeman, Clodagh Sweeney, Luca Dello Strologo, Lars Pape |
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| 520 | |a Recurrence of primary disease is one of the major risks for allograft loss after pediatric RTx. The risk of recurrence of FSGS/SRNS after pediatric RTx in particular can be up to 86% in idiopathic cases. There is a need for consensus recommendations on its prevention and treatment. The CERTAIN study group has therefore performed a thorough literature search based on the PICO model of clinical questions to formulate educated statements to guide the clinician in the process of decision-making. A set of educated statements on prevention and treatment of FSGS/SRNS after pediatric RTx has been generated after careful evaluation of available evidence and thorough panel discussion. We do not recommend routine nephrectomy prior to transplantation; neither do we recommend abstaining from living donation. Special attendance needs to be given to those patients who had already experienced graft loss due to FSGS/SRNS recurrence. Early PE or IA with or without high-dose CsA and/or rituximab seems to be most promising to induce remission. The educated statements presented here acknowledge that FSGS/SRNS recurrence after pediatric RTx remains a major concern and is associated with shorter graft survival or even graft loss. The value of any recommendation needs to take into account that evidence is based on cohorts that differ in ethnicity, pre-transplant history, immunosuppressive regimen, definition of recurrence (eg, clinical and/or histological diagnosis) and treatment modalities of recurrence. | ||
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10.1111/petr.13955 doi (DE-627)1869414691 (DE-599)KXP1869414691 (OCoLC)1425217386 DE-627 ger DE-627 rda eng Weber, Lutz T. 1969- verfasserin (DE-588)120903792 (DE-627)705077225 (DE-576)292439997 aut Clinical practice recommendations for recurrence of focal and segmental glomerulosclerosis/steroid-resistant nephrotic syndrome Lutz T. Weber, Burkhard Tönshoff, Ryszard Grenda, Antonia Bouts, Rezan Topaloglu, Bora Gülhan, Nikoleta Printza, Atif Awan, Nina Battelino, Rasmus Ehren, Peter F. Hoyer, Gregor Novljan, Stephen D. Marks, Jun Oh, Agnieszka Prytula, Tomas Seeman, Clodagh Sweeney, Luca Dello Strologo, Lars Pape 2021 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 06.11.2023 Recurrence of primary disease is one of the major risks for allograft loss after pediatric RTx. The risk of recurrence of FSGS/SRNS after pediatric RTx in particular can be up to 86% in idiopathic cases. There is a need for consensus recommendations on its prevention and treatment. The CERTAIN study group has therefore performed a thorough literature search based on the PICO model of clinical questions to formulate educated statements to guide the clinician in the process of decision-making. A set of educated statements on prevention and treatment of FSGS/SRNS after pediatric RTx has been generated after careful evaluation of available evidence and thorough panel discussion. We do not recommend routine nephrectomy prior to transplantation; neither do we recommend abstaining from living donation. Special attendance needs to be given to those patients who had already experienced graft loss due to FSGS/SRNS recurrence. Early PE or IA with or without high-dose CsA and/or rituximab seems to be most promising to induce remission. The educated statements presented here acknowledge that FSGS/SRNS recurrence after pediatric RTx remains a major concern and is associated with shorter graft survival or even graft loss. The value of any recommendation needs to take into account that evidence is based on cohorts that differ in ethnicity, pre-transplant history, immunosuppressive regimen, definition of recurrence (eg, clinical and/or histological diagnosis) and treatment modalities of recurrence. children focal-segmental glomerulosclerosis recurrence renal transplantation steroid-resistant nephrotic syndrome Tönshoff, Burkhard verfasserin (DE-588)1032445823 (DE-627)738463493 (DE-576)173494196 aut Grenda, Ryszard verfasserin aut Bouts, Antonia verfasserin aut Topaloglu, Rezan verfasserin aut Gülhan, Bora verfasserin aut Printza, Nikoleta verfasserin aut Awan, Atif verfasserin aut Battelino, Nina verfasserin aut Ehren, Rasmus verfasserin aut Hoyer, Peter F. verfasserin aut Novljan, Gregor verfasserin aut Marks, Stephen D. verfasserin aut Oh, Jun verfasserin aut Prytula, Agnieszka verfasserin aut Seeman, Tomas verfasserin aut Sweeney, Clodagh verfasserin aut Dello Strologo, Luca verfasserin aut Pape, Lars verfasserin aut Enthalten in Pediatric transplantation Oxford [u.a.] : Wiley-Blackwell, 1999 25(2021), 3 vom: Mai, Artikel-ID e13955, Seite 1-10 Online-Ressource (DE-627)320471683 (DE-600)2008614-3 (DE-576)09116964X 1399-3046 nnns volume:25 year:2021 number:3 month:05 elocationid:e13955 pages:1-10 extent:10 https://doi.org/10.1111/petr.13955 Verlag Resolving-System kostenfrei Volltext https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13955 Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 25 2021 3 5 e13955 1-10 10 2013 01 DE-16-250 4403031404 00 --%%-- --%%-- --%%-- --%%-- l01 06-11-23 2403 01 DE-LFER 4424994732 00 --%%-- --%%-- n --%%-- l01 04-12-23 2403 01 DE-LFER https://doi.org/10.1111/petr.13955 2403 01 DE-LFER https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13955 2013 01 DE-16-250 00 s hd2021 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_19 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1450051391 Tönshoff, Burkhard 2013 01 DE-16-250 04 k (DE-627)1416740988 Zentrum für Kinder- und Jugendmedizin 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_2 |
| spelling |
10.1111/petr.13955 doi (DE-627)1869414691 (DE-599)KXP1869414691 (OCoLC)1425217386 DE-627 ger DE-627 rda eng Weber, Lutz T. 1969- verfasserin (DE-588)120903792 (DE-627)705077225 (DE-576)292439997 aut Clinical practice recommendations for recurrence of focal and segmental glomerulosclerosis/steroid-resistant nephrotic syndrome Lutz T. Weber, Burkhard Tönshoff, Ryszard Grenda, Antonia Bouts, Rezan Topaloglu, Bora Gülhan, Nikoleta Printza, Atif Awan, Nina Battelino, Rasmus Ehren, Peter F. Hoyer, Gregor Novljan, Stephen D. Marks, Jun Oh, Agnieszka Prytula, Tomas Seeman, Clodagh Sweeney, Luca Dello Strologo, Lars Pape 2021 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 06.11.2023 Recurrence of primary disease is one of the major risks for allograft loss after pediatric RTx. The risk of recurrence of FSGS/SRNS after pediatric RTx in particular can be up to 86% in idiopathic cases. There is a need for consensus recommendations on its prevention and treatment. The CERTAIN study group has therefore performed a thorough literature search based on the PICO model of clinical questions to formulate educated statements to guide the clinician in the process of decision-making. A set of educated statements on prevention and treatment of FSGS/SRNS after pediatric RTx has been generated after careful evaluation of available evidence and thorough panel discussion. We do not recommend routine nephrectomy prior to transplantation; neither do we recommend abstaining from living donation. Special attendance needs to be given to those patients who had already experienced graft loss due to FSGS/SRNS recurrence. Early PE or IA with or without high-dose CsA and/or rituximab seems to be most promising to induce remission. The educated statements presented here acknowledge that FSGS/SRNS recurrence after pediatric RTx remains a major concern and is associated with shorter graft survival or even graft loss. The value of any recommendation needs to take into account that evidence is based on cohorts that differ in ethnicity, pre-transplant history, immunosuppressive regimen, definition of recurrence (eg, clinical and/or histological diagnosis) and treatment modalities of recurrence. children focal-segmental glomerulosclerosis recurrence renal transplantation steroid-resistant nephrotic syndrome Tönshoff, Burkhard verfasserin (DE-588)1032445823 (DE-627)738463493 (DE-576)173494196 aut Grenda, Ryszard verfasserin aut Bouts, Antonia verfasserin aut Topaloglu, Rezan verfasserin aut Gülhan, Bora verfasserin aut Printza, Nikoleta verfasserin aut Awan, Atif verfasserin aut Battelino, Nina verfasserin aut Ehren, Rasmus verfasserin aut Hoyer, Peter F. verfasserin aut Novljan, Gregor verfasserin aut Marks, Stephen D. verfasserin aut Oh, Jun verfasserin aut Prytula, Agnieszka verfasserin aut Seeman, Tomas verfasserin aut Sweeney, Clodagh verfasserin aut Dello Strologo, Luca verfasserin aut Pape, Lars verfasserin aut Enthalten in Pediatric transplantation Oxford [u.a.] : Wiley-Blackwell, 1999 25(2021), 3 vom: Mai, Artikel-ID e13955, Seite 1-10 Online-Ressource (DE-627)320471683 (DE-600)2008614-3 (DE-576)09116964X 1399-3046 nnns volume:25 year:2021 number:3 month:05 elocationid:e13955 pages:1-10 extent:10 https://doi.org/10.1111/petr.13955 Verlag Resolving-System kostenfrei Volltext https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13955 Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 25 2021 3 5 e13955 1-10 10 2013 01 DE-16-250 4403031404 00 --%%-- --%%-- --%%-- --%%-- l01 06-11-23 2403 01 DE-LFER 4424994732 00 --%%-- --%%-- n --%%-- l01 04-12-23 2403 01 DE-LFER https://doi.org/10.1111/petr.13955 2403 01 DE-LFER https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13955 2013 01 DE-16-250 00 s hd2021 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_19 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1450051391 Tönshoff, Burkhard 2013 01 DE-16-250 04 k (DE-627)1416740988 Zentrum für Kinder- und Jugendmedizin 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_2 |
| allfields_unstemmed |
10.1111/petr.13955 doi (DE-627)1869414691 (DE-599)KXP1869414691 (OCoLC)1425217386 DE-627 ger DE-627 rda eng Weber, Lutz T. 1969- verfasserin (DE-588)120903792 (DE-627)705077225 (DE-576)292439997 aut Clinical practice recommendations for recurrence of focal and segmental glomerulosclerosis/steroid-resistant nephrotic syndrome Lutz T. Weber, Burkhard Tönshoff, Ryszard Grenda, Antonia Bouts, Rezan Topaloglu, Bora Gülhan, Nikoleta Printza, Atif Awan, Nina Battelino, Rasmus Ehren, Peter F. Hoyer, Gregor Novljan, Stephen D. Marks, Jun Oh, Agnieszka Prytula, Tomas Seeman, Clodagh Sweeney, Luca Dello Strologo, Lars Pape 2021 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 06.11.2023 Recurrence of primary disease is one of the major risks for allograft loss after pediatric RTx. The risk of recurrence of FSGS/SRNS after pediatric RTx in particular can be up to 86% in idiopathic cases. There is a need for consensus recommendations on its prevention and treatment. The CERTAIN study group has therefore performed a thorough literature search based on the PICO model of clinical questions to formulate educated statements to guide the clinician in the process of decision-making. A set of educated statements on prevention and treatment of FSGS/SRNS after pediatric RTx has been generated after careful evaluation of available evidence and thorough panel discussion. We do not recommend routine nephrectomy prior to transplantation; neither do we recommend abstaining from living donation. Special attendance needs to be given to those patients who had already experienced graft loss due to FSGS/SRNS recurrence. Early PE or IA with or without high-dose CsA and/or rituximab seems to be most promising to induce remission. The educated statements presented here acknowledge that FSGS/SRNS recurrence after pediatric RTx remains a major concern and is associated with shorter graft survival or even graft loss. The value of any recommendation needs to take into account that evidence is based on cohorts that differ in ethnicity, pre-transplant history, immunosuppressive regimen, definition of recurrence (eg, clinical and/or histological diagnosis) and treatment modalities of recurrence. children focal-segmental glomerulosclerosis recurrence renal transplantation steroid-resistant nephrotic syndrome Tönshoff, Burkhard verfasserin (DE-588)1032445823 (DE-627)738463493 (DE-576)173494196 aut Grenda, Ryszard verfasserin aut Bouts, Antonia verfasserin aut Topaloglu, Rezan verfasserin aut Gülhan, Bora verfasserin aut Printza, Nikoleta verfasserin aut Awan, Atif verfasserin aut Battelino, Nina verfasserin aut Ehren, Rasmus verfasserin aut Hoyer, Peter F. verfasserin aut Novljan, Gregor verfasserin aut Marks, Stephen D. verfasserin aut Oh, Jun verfasserin aut Prytula, Agnieszka verfasserin aut Seeman, Tomas verfasserin aut Sweeney, Clodagh verfasserin aut Dello Strologo, Luca verfasserin aut Pape, Lars verfasserin aut Enthalten in Pediatric transplantation Oxford [u.a.] : Wiley-Blackwell, 1999 25(2021), 3 vom: Mai, Artikel-ID e13955, Seite 1-10 Online-Ressource (DE-627)320471683 (DE-600)2008614-3 (DE-576)09116964X 1399-3046 nnns volume:25 year:2021 number:3 month:05 elocationid:e13955 pages:1-10 extent:10 https://doi.org/10.1111/petr.13955 Verlag Resolving-System kostenfrei Volltext https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13955 Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 25 2021 3 5 e13955 1-10 10 2013 01 DE-16-250 4403031404 00 --%%-- --%%-- --%%-- --%%-- l01 06-11-23 2403 01 DE-LFER 4424994732 00 --%%-- --%%-- n --%%-- l01 04-12-23 2403 01 DE-LFER https://doi.org/10.1111/petr.13955 2403 01 DE-LFER https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13955 2013 01 DE-16-250 00 s hd2021 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_19 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1450051391 Tönshoff, Burkhard 2013 01 DE-16-250 04 k (DE-627)1416740988 Zentrum für Kinder- und Jugendmedizin 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_2 |
| allfieldsGer |
10.1111/petr.13955 doi (DE-627)1869414691 (DE-599)KXP1869414691 (OCoLC)1425217386 DE-627 ger DE-627 rda eng Weber, Lutz T. 1969- verfasserin (DE-588)120903792 (DE-627)705077225 (DE-576)292439997 aut Clinical practice recommendations for recurrence of focal and segmental glomerulosclerosis/steroid-resistant nephrotic syndrome Lutz T. Weber, Burkhard Tönshoff, Ryszard Grenda, Antonia Bouts, Rezan Topaloglu, Bora Gülhan, Nikoleta Printza, Atif Awan, Nina Battelino, Rasmus Ehren, Peter F. Hoyer, Gregor Novljan, Stephen D. Marks, Jun Oh, Agnieszka Prytula, Tomas Seeman, Clodagh Sweeney, Luca Dello Strologo, Lars Pape 2021 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 06.11.2023 Recurrence of primary disease is one of the major risks for allograft loss after pediatric RTx. The risk of recurrence of FSGS/SRNS after pediatric RTx in particular can be up to 86% in idiopathic cases. There is a need for consensus recommendations on its prevention and treatment. The CERTAIN study group has therefore performed a thorough literature search based on the PICO model of clinical questions to formulate educated statements to guide the clinician in the process of decision-making. A set of educated statements on prevention and treatment of FSGS/SRNS after pediatric RTx has been generated after careful evaluation of available evidence and thorough panel discussion. We do not recommend routine nephrectomy prior to transplantation; neither do we recommend abstaining from living donation. Special attendance needs to be given to those patients who had already experienced graft loss due to FSGS/SRNS recurrence. Early PE or IA with or without high-dose CsA and/or rituximab seems to be most promising to induce remission. The educated statements presented here acknowledge that FSGS/SRNS recurrence after pediatric RTx remains a major concern and is associated with shorter graft survival or even graft loss. The value of any recommendation needs to take into account that evidence is based on cohorts that differ in ethnicity, pre-transplant history, immunosuppressive regimen, definition of recurrence (eg, clinical and/or histological diagnosis) and treatment modalities of recurrence. children focal-segmental glomerulosclerosis recurrence renal transplantation steroid-resistant nephrotic syndrome Tönshoff, Burkhard verfasserin (DE-588)1032445823 (DE-627)738463493 (DE-576)173494196 aut Grenda, Ryszard verfasserin aut Bouts, Antonia verfasserin aut Topaloglu, Rezan verfasserin aut Gülhan, Bora verfasserin aut Printza, Nikoleta verfasserin aut Awan, Atif verfasserin aut Battelino, Nina verfasserin aut Ehren, Rasmus verfasserin aut Hoyer, Peter F. verfasserin aut Novljan, Gregor verfasserin aut Marks, Stephen D. verfasserin aut Oh, Jun verfasserin aut Prytula, Agnieszka verfasserin aut Seeman, Tomas verfasserin aut Sweeney, Clodagh verfasserin aut Dello Strologo, Luca verfasserin aut Pape, Lars verfasserin aut Enthalten in Pediatric transplantation Oxford [u.a.] : Wiley-Blackwell, 1999 25(2021), 3 vom: Mai, Artikel-ID e13955, Seite 1-10 Online-Ressource (DE-627)320471683 (DE-600)2008614-3 (DE-576)09116964X 1399-3046 nnns volume:25 year:2021 number:3 month:05 elocationid:e13955 pages:1-10 extent:10 https://doi.org/10.1111/petr.13955 Verlag Resolving-System kostenfrei Volltext https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13955 Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 25 2021 3 5 e13955 1-10 10 2013 01 DE-16-250 4403031404 00 --%%-- --%%-- --%%-- --%%-- l01 06-11-23 2403 01 DE-LFER 4424994732 00 --%%-- --%%-- n --%%-- l01 04-12-23 2403 01 DE-LFER https://doi.org/10.1111/petr.13955 2403 01 DE-LFER https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13955 2013 01 DE-16-250 00 s hd2021 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_19 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1450051391 Tönshoff, Burkhard 2013 01 DE-16-250 04 k (DE-627)1416740988 Zentrum für Kinder- und Jugendmedizin 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_2 |
| allfieldsSound |
10.1111/petr.13955 doi (DE-627)1869414691 (DE-599)KXP1869414691 (OCoLC)1425217386 DE-627 ger DE-627 rda eng Weber, Lutz T. 1969- verfasserin (DE-588)120903792 (DE-627)705077225 (DE-576)292439997 aut Clinical practice recommendations for recurrence of focal and segmental glomerulosclerosis/steroid-resistant nephrotic syndrome Lutz T. Weber, Burkhard Tönshoff, Ryszard Grenda, Antonia Bouts, Rezan Topaloglu, Bora Gülhan, Nikoleta Printza, Atif Awan, Nina Battelino, Rasmus Ehren, Peter F. Hoyer, Gregor Novljan, Stephen D. Marks, Jun Oh, Agnieszka Prytula, Tomas Seeman, Clodagh Sweeney, Luca Dello Strologo, Lars Pape 2021 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 06.11.2023 Recurrence of primary disease is one of the major risks for allograft loss after pediatric RTx. The risk of recurrence of FSGS/SRNS after pediatric RTx in particular can be up to 86% in idiopathic cases. There is a need for consensus recommendations on its prevention and treatment. The CERTAIN study group has therefore performed a thorough literature search based on the PICO model of clinical questions to formulate educated statements to guide the clinician in the process of decision-making. A set of educated statements on prevention and treatment of FSGS/SRNS after pediatric RTx has been generated after careful evaluation of available evidence and thorough panel discussion. We do not recommend routine nephrectomy prior to transplantation; neither do we recommend abstaining from living donation. Special attendance needs to be given to those patients who had already experienced graft loss due to FSGS/SRNS recurrence. Early PE or IA with or without high-dose CsA and/or rituximab seems to be most promising to induce remission. The educated statements presented here acknowledge that FSGS/SRNS recurrence after pediatric RTx remains a major concern and is associated with shorter graft survival or even graft loss. The value of any recommendation needs to take into account that evidence is based on cohorts that differ in ethnicity, pre-transplant history, immunosuppressive regimen, definition of recurrence (eg, clinical and/or histological diagnosis) and treatment modalities of recurrence. children focal-segmental glomerulosclerosis recurrence renal transplantation steroid-resistant nephrotic syndrome Tönshoff, Burkhard verfasserin (DE-588)1032445823 (DE-627)738463493 (DE-576)173494196 aut Grenda, Ryszard verfasserin aut Bouts, Antonia verfasserin aut Topaloglu, Rezan verfasserin aut Gülhan, Bora verfasserin aut Printza, Nikoleta verfasserin aut Awan, Atif verfasserin aut Battelino, Nina verfasserin aut Ehren, Rasmus verfasserin aut Hoyer, Peter F. verfasserin aut Novljan, Gregor verfasserin aut Marks, Stephen D. verfasserin aut Oh, Jun verfasserin aut Prytula, Agnieszka verfasserin aut Seeman, Tomas verfasserin aut Sweeney, Clodagh verfasserin aut Dello Strologo, Luca verfasserin aut Pape, Lars verfasserin aut Enthalten in Pediatric transplantation Oxford [u.a.] : Wiley-Blackwell, 1999 25(2021), 3 vom: Mai, Artikel-ID e13955, Seite 1-10 Online-Ressource (DE-627)320471683 (DE-600)2008614-3 (DE-576)09116964X 1399-3046 nnns volume:25 year:2021 number:3 month:05 elocationid:e13955 pages:1-10 extent:10 https://doi.org/10.1111/petr.13955 Verlag Resolving-System kostenfrei Volltext https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13955 Verlag kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 GBV_ILN_2403 GBV_ILN_2403 ISIL_DE-LFER AR 25 2021 3 5 e13955 1-10 10 2013 01 DE-16-250 4403031404 00 --%%-- --%%-- --%%-- --%%-- l01 06-11-23 2403 01 DE-LFER 4424994732 00 --%%-- --%%-- n --%%-- l01 04-12-23 2403 01 DE-LFER https://doi.org/10.1111/petr.13955 2403 01 DE-LFER https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13955 2013 01 DE-16-250 00 s hd2021 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_19 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1450051391 Tönshoff, Burkhard 2013 01 DE-16-250 04 k (DE-627)1416740988 Zentrum für Kinder- und Jugendmedizin 2013 01 DE-16-250 04 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_2 |
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Enthalten in Pediatric transplantation 25(2021), 3 vom: Mai, Artikel-ID e13955, Seite 1-10 volume:25 year:2021 number:3 month:05 elocationid:e13955 pages:1-10 extent:10 |
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Enthalten in Pediatric transplantation 25(2021), 3 vom: Mai, Artikel-ID e13955, Seite 1-10 volume:25 year:2021 number:3 month:05 elocationid:e13955 pages:1-10 extent:10 |
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children focal-segmental glomerulosclerosis recurrence renal transplantation steroid-resistant nephrotic syndrome |
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Weber, Lutz T. @@aut@@ Tönshoff, Burkhard @@aut@@ Grenda, Ryszard @@aut@@ Bouts, Antonia @@aut@@ Topaloglu, Rezan @@aut@@ Gülhan, Bora @@aut@@ Printza, Nikoleta @@aut@@ Awan, Atif @@aut@@ Battelino, Nina @@aut@@ Ehren, Rasmus @@aut@@ Hoyer, Peter F. @@aut@@ Novljan, Gregor @@aut@@ Marks, Stephen D. @@aut@@ Oh, Jun @@aut@@ Prytula, Agnieszka @@aut@@ Seeman, Tomas @@aut@@ Sweeney, Clodagh @@aut@@ Dello Strologo, Luca @@aut@@ Pape, Lars @@aut@@ |
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Clinical practice recommendations for recurrence of focal and segmental glomerulosclerosis/steroid-resistant nephrotic syndrome Lutz T. Weber, Burkhard Tönshoff, Ryszard Grenda, Antonia Bouts, Rezan Topaloglu, Bora Gülhan, Nikoleta Printza, Atif Awan, Nina Battelino, Rasmus Ehren, Peter F. Hoyer, Gregor Novljan, Stephen D. Marks, Jun Oh, Agnieszka Prytula, Tomas Seeman, Clodagh Sweeney, Luca Dello Strologo, Lars Pape |
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clinical practice recommendations for recurrence of focal and segmental glomerulosclerosis/steroid-resistant nephrotic syndrome |
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Clinical practice recommendations for recurrence of focal and segmental glomerulosclerosis/steroid-resistant nephrotic syndrome |
| abstract |
Recurrence of primary disease is one of the major risks for allograft loss after pediatric RTx. The risk of recurrence of FSGS/SRNS after pediatric RTx in particular can be up to 86% in idiopathic cases. There is a need for consensus recommendations on its prevention and treatment. The CERTAIN study group has therefore performed a thorough literature search based on the PICO model of clinical questions to formulate educated statements to guide the clinician in the process of decision-making. A set of educated statements on prevention and treatment of FSGS/SRNS after pediatric RTx has been generated after careful evaluation of available evidence and thorough panel discussion. We do not recommend routine nephrectomy prior to transplantation; neither do we recommend abstaining from living donation. Special attendance needs to be given to those patients who had already experienced graft loss due to FSGS/SRNS recurrence. Early PE or IA with or without high-dose CsA and/or rituximab seems to be most promising to induce remission. The educated statements presented here acknowledge that FSGS/SRNS recurrence after pediatric RTx remains a major concern and is associated with shorter graft survival or even graft loss. The value of any recommendation needs to take into account that evidence is based on cohorts that differ in ethnicity, pre-transplant history, immunosuppressive regimen, definition of recurrence (eg, clinical and/or histological diagnosis) and treatment modalities of recurrence. Gesehen am 06.11.2023 |
| abstractGer |
Recurrence of primary disease is one of the major risks for allograft loss after pediatric RTx. The risk of recurrence of FSGS/SRNS after pediatric RTx in particular can be up to 86% in idiopathic cases. There is a need for consensus recommendations on its prevention and treatment. The CERTAIN study group has therefore performed a thorough literature search based on the PICO model of clinical questions to formulate educated statements to guide the clinician in the process of decision-making. A set of educated statements on prevention and treatment of FSGS/SRNS after pediatric RTx has been generated after careful evaluation of available evidence and thorough panel discussion. We do not recommend routine nephrectomy prior to transplantation; neither do we recommend abstaining from living donation. Special attendance needs to be given to those patients who had already experienced graft loss due to FSGS/SRNS recurrence. Early PE or IA with or without high-dose CsA and/or rituximab seems to be most promising to induce remission. The educated statements presented here acknowledge that FSGS/SRNS recurrence after pediatric RTx remains a major concern and is associated with shorter graft survival or even graft loss. The value of any recommendation needs to take into account that evidence is based on cohorts that differ in ethnicity, pre-transplant history, immunosuppressive regimen, definition of recurrence (eg, clinical and/or histological diagnosis) and treatment modalities of recurrence. Gesehen am 06.11.2023 |
| abstract_unstemmed |
Recurrence of primary disease is one of the major risks for allograft loss after pediatric RTx. The risk of recurrence of FSGS/SRNS after pediatric RTx in particular can be up to 86% in idiopathic cases. There is a need for consensus recommendations on its prevention and treatment. The CERTAIN study group has therefore performed a thorough literature search based on the PICO model of clinical questions to formulate educated statements to guide the clinician in the process of decision-making. A set of educated statements on prevention and treatment of FSGS/SRNS after pediatric RTx has been generated after careful evaluation of available evidence and thorough panel discussion. We do not recommend routine nephrectomy prior to transplantation; neither do we recommend abstaining from living donation. Special attendance needs to be given to those patients who had already experienced graft loss due to FSGS/SRNS recurrence. Early PE or IA with or without high-dose CsA and/or rituximab seems to be most promising to induce remission. The educated statements presented here acknowledge that FSGS/SRNS recurrence after pediatric RTx remains a major concern and is associated with shorter graft survival or even graft loss. The value of any recommendation needs to take into account that evidence is based on cohorts that differ in ethnicity, pre-transplant history, immunosuppressive regimen, definition of recurrence (eg, clinical and/or histological diagnosis) and treatment modalities of recurrence. Gesehen am 06.11.2023 |
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Clinical practice recommendations for recurrence of focal and segmental glomerulosclerosis/steroid-resistant nephrotic syndrome |
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Tönshoff, Burkhard Grenda, Ryszard Bouts, Antonia Topaloglu, Rezan Gülhan, Bora Printza, Nikoleta Awan, Atif Battelino, Nina Ehren, Rasmus Hoyer, Peter F. Novljan, Gregor Marks, Stephen D. Oh, Jun Prytula, Agnieszka Seeman, Tomas Sweeney, Clodagh Dello Strologo, Luca Pape, Lars |
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