Association of systemic medication use with Glaucoma and intraocular pressure : the European Eye Epidemiology Consortium

Purpose - To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population. - Design - Meta-analysis of 11 population-based cohort studies of the European Eye Epidemiology Consortium. - Participants - The glaucoma analyses included 143 240 participants and the IOP analyses included 47 177 participants. - Methods - We examined associations of 4 categories of systemic medications—antihypertensive medications (β-blockers, diuretics, calcium channel blockers [CCBs], α-agonists, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers), lipid-lowering medications, antidepressants, and antidiabetic medications—with glaucoma prevalence and IOP. Glaucoma ascertainment and IOP measurement method were according to individual study protocols. Results of multivariable regression analyses of each study were pooled using random effects meta-analyses. Associations with antidiabetic medications were examined in participants with diabetes only. - Main Outcome Measures - Glaucoma prevalence and IOP. - Results - In the meta-analyses of our maximally adjusted multivariable models, use of CCBs was associated with a higher prevalence of glaucoma (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.08 to 1.39). This association was stronger for monotherapy of CCBs with direct cardiac effects (OR, 1.96; 95% CI, 1.23 to 3.12). No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with glaucoma. Use of systemic β-blockers was associated with a lower IOP (β coefficient, −0.33 mmHg; 95% CI, −0.57 to −0.08 mmHg). Monotherapy of both selective systemic β-blockers (β coefficient, −0.45 mmHg; 95% CI −0.74 to −0.16 mmHg) and nonselective systemic β-blockers (β coefficient, −0.54 mmHg; 95% CI, −0.94 to −0.15 mmHg) was associated with lower IOP. A suggestive association was found between use of high-ceiling diuretics and lower IOP (β coefficient, −0.30 mmHg; 95% CI, −0.47 to −0.14 mmHg) but not when used as monotherapy. No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with IOP. - Conclusions - We identified a potentially harmful association between use of CCBs and glaucoma prevalence. Additionally, we observed and quantified the association of lower IOP with systemic β-blocker use. Both findings potentially are important, given that patients with glaucoma frequently use systemic antihypertensive medications. Determining causality of the CCB association should be a research priority. - Financial Disclosure(s) - Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Vergroesen, Joëlle [verfasserIn] Schuster, Alexander K. [verfasserIn] Stuart, Kelsey V. [verfasserIn] Asefa, Nigus G. [verfasserIn] Cougnard-Grégoire, Audrey [verfasserIn] Delcourt, Cécile [verfasserIn] Schweitzer, Cédric [verfasserIn] Barreto, Patrícia [verfasserIn] Coimbra, Rita [verfasserIn] Foster, Paul J. [verfasserIn] Luben, Robert N. [verfasserIn] Pfeiffer, Norbert [verfasserIn] Stingl, Julia V. [verfasserIn] Kirsten, Toralf [verfasserIn] Rauscher, Franziska G. [verfasserIn] Wirkner, Kerstin [verfasserIn] Jansonius, Nomdo M. [verfasserIn] Arnould, Louis [verfasserIn] Creuzot-Garcher, Catherine P. [verfasserIn] Stricker, Bruno H. [verfasserIn] Keskini, Christina [verfasserIn] Topouzis, Fotis [verfasserIn] Bertelsen, Geir [verfasserIn] Eggen, Anne E. [verfasserIn] Bikbov, Mukharram M. [verfasserIn] Jonas, Jost B. - 1958- [verfasserIn] Klaver, Caroline C. W. [verfasserIn] Ramdas, Wishal D. [verfasserIn] Khawaja, Anthony P. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	September 2023

Schlagwörter:	Epidemiology Glaucoma Intraocular pressure Systemic medication

Anmerkung:	Online verfügbar: 6. Mai 2023, Artikelversion: 18. August 2023 Gesehen am 15.11.2023
Umfang:	14

Übergeordnetes Werk:	Enthalten in: Ophthalmology - Amsterdam [u.a.] : Elsevier, 1978, 130(2023), 9 vom: Sept., Seite 893-906
Übergeordnetes Werk:	volume:130 ; year:2023 ; number:9 ; month:09 ; pages:893-906 ; extent:14

Links:	Volltext Volltext

DOI / URN:	10.1016/j.ophtha.2023.05.001

Katalog-ID:	1870336453

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520			\|a Purpose - To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population. - Design - Meta-analysis of 11 population-based cohort studies of the European Eye Epidemiology Consortium. - Participants - The glaucoma analyses included 143 240 participants and the IOP analyses included 47 177 participants. - Methods - We examined associations of 4 categories of systemic medications—antihypertensive medications (β-blockers, diuretics, calcium channel blockers [CCBs], α-agonists, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers), lipid-lowering medications, antidepressants, and antidiabetic medications—with glaucoma prevalence and IOP. Glaucoma ascertainment and IOP measurement method were according to individual study protocols. Results of multivariable regression analyses of each study were pooled using random effects meta-analyses. Associations with antidiabetic medications were examined in participants with diabetes only. - Main Outcome Measures - Glaucoma prevalence and IOP. - Results - In the meta-analyses of our maximally adjusted multivariable models, use of CCBs was associated with a higher prevalence of glaucoma (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.08 to 1.39). This association was stronger for monotherapy of CCBs with direct cardiac effects (OR, 1.96; 95% CI, 1.23 to 3.12). No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with glaucoma. Use of systemic β-blockers was associated with a lower IOP (β coefficient, −0.33 mmHg; 95% CI, −0.57 to −0.08 mmHg). Monotherapy of both selective systemic β-blockers (β coefficient, −0.45 mmHg; 95% CI −0.74 to −0.16 mmHg) and nonselective systemic β-blockers (β coefficient, −0.54 mmHg; 95% CI, −0.94 to −0.15 mmHg) was associated with lower IOP. A suggestive association was found between use of high-ceiling diuretics and lower IOP (β coefficient, −0.30 mmHg; 95% CI, −0.47 to −0.14 mmHg) but not when used as monotherapy. No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with IOP. - Conclusions - We identified a potentially harmful association between use of CCBs and glaucoma prevalence. Additionally, we observed and quantified the association of lower IOP with systemic β-blocker use. Both findings potentially are important, given that patients with glaucoma frequently use systemic antihypertensive medications. Determining causality of the CCB association should be a research priority. - Financial Disclosure(s) - Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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700	1		\|a Foster, Paul J. \|e verfasserin \|4 aut
700	1		\|a Luben, Robert N. \|e verfasserin \|4 aut
700	1		\|a Pfeiffer, Norbert \|e verfasserin \|4 aut
700	1		\|a Stingl, Julia V. \|e verfasserin \|4 aut
700	1		\|a Kirsten, Toralf \|e verfasserin \|4 aut
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700	1		\|a Jansonius, Nomdo M. \|e verfasserin \|4 aut
700	1		\|a Arnould, Louis \|e verfasserin \|4 aut
700	1		\|a Creuzot-Garcher, Catherine P. \|e verfasserin \|4 aut
700	1		\|a Stricker, Bruno H. \|e verfasserin \|4 aut
700	1		\|a Keskini, Christina \|e verfasserin \|4 aut
700	1		\|a Topouzis, Fotis \|e verfasserin \|4 aut
700	1		\|a Bertelsen, Geir \|e verfasserin \|4 aut
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700	1		\|a Ramdas, Wishal D. \|e verfasserin \|4 aut
700	1		\|a Khawaja, Anthony P. \|e verfasserin \|4 aut
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allfields	10.1016/j.ophtha.2023.05.001 doi (DE-627)1870336453 (DE-599)KXP1870336453 (OCoLC)1425209375 DE-627 ger DE-627 rda eng Vergroesen, Joëlle verfasserin (DE-588)1309912262 (DE-627)1870336844 aut Association of systemic medication use with Glaucoma and intraocular pressure the European Eye Epidemiology Consortium Joëlle E. Vergroesen, Alexander K. Schuster, Kelsey V. Stuart, Nigus G. Asefa, Audrey Cougnard-Grégoire, Cécile Delcourt, Cédric Schweitzer, Patrícia Barreto, Rita Coimbra, Paul J. Foster, Robert N. Luben, Norbert Pfeiffer, Julia V. Stingl, Toralf Kirsten, Franziska G. Rauscher, Kerstin Wirkner, Nomdo M. Jansonius, Louis Arnould, Catherine P. Creuzot-Garcher, Bruno H. Stricker, Christina Keskini, Fotis Topouzis, Geir Bertelsen, Anne E. Eggen, Mukharram M. Bikbov, Jost B. Jonas, Caroline C. W. Klaver, Wishal D. Ramdas, Anthony P. Khawaja, on behalf of the European Eye Epidemiology Consortium September 2023 14 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Online verfügbar: 6. Mai 2023, Artikelversion: 18. August 2023 Gesehen am 15.11.2023 Purpose - To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population. - Design - Meta-analysis of 11 population-based cohort studies of the European Eye Epidemiology Consortium. - Participants - The glaucoma analyses included 143 240 participants and the IOP analyses included 47 177 participants. - Methods - We examined associations of 4 categories of systemic medications—antihypertensive medications (β-blockers, diuretics, calcium channel blockers [CCBs], α-agonists, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers), lipid-lowering medications, antidepressants, and antidiabetic medications—with glaucoma prevalence and IOP. Glaucoma ascertainment and IOP measurement method were according to individual study protocols. Results of multivariable regression analyses of each study were pooled using random effects meta-analyses. Associations with antidiabetic medications were examined in participants with diabetes only. - Main Outcome Measures - Glaucoma prevalence and IOP. - Results - In the meta-analyses of our maximally adjusted multivariable models, use of CCBs was associated with a higher prevalence of glaucoma (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.08 to 1.39). This association was stronger for monotherapy of CCBs with direct cardiac effects (OR, 1.96; 95% CI, 1.23 to 3.12). No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with glaucoma. Use of systemic β-blockers was associated with a lower IOP (β coefficient, −0.33 mmHg; 95% CI, −0.57 to −0.08 mmHg). Monotherapy of both selective systemic β-blockers (β coefficient, −0.45 mmHg; 95% CI −0.74 to −0.16 mmHg) and nonselective systemic β-blockers (β coefficient, −0.54 mmHg; 95% CI, −0.94 to −0.15 mmHg) was associated with lower IOP. A suggestive association was found between use of high-ceiling diuretics and lower IOP (β coefficient, −0.30 mmHg; 95% CI, −0.47 to −0.14 mmHg) but not when used as monotherapy. No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with IOP. - Conclusions - We identified a potentially harmful association between use of CCBs and glaucoma prevalence. Additionally, we observed and quantified the association of lower IOP with systemic β-blocker use. Both findings potentially are important, given that patients with glaucoma frequently use systemic antihypertensive medications. Determining causality of the CCB association should be a research priority. - Financial Disclosure(s) - Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. Epidemiology Glaucoma Intraocular pressure Systemic medication Schuster, Alexander K. verfasserin aut Stuart, Kelsey V. verfasserin aut Asefa, Nigus G. verfasserin aut Cougnard-Grégoire, Audrey verfasserin aut Delcourt, Cécile verfasserin aut Schweitzer, Cédric verfasserin aut Barreto, Patrícia verfasserin aut Coimbra, Rita verfasserin aut Foster, Paul J. verfasserin aut Luben, Robert N. verfasserin aut Pfeiffer, Norbert verfasserin aut Stingl, Julia V. verfasserin aut Kirsten, Toralf verfasserin aut Rauscher, Franziska G. verfasserin aut Wirkner, Kerstin verfasserin aut Jansonius, Nomdo M. verfasserin aut Arnould, Louis verfasserin aut Creuzot-Garcher, Catherine P. verfasserin aut Stricker, Bruno H. verfasserin aut Keskini, Christina verfasserin aut Topouzis, Fotis verfasserin aut Bertelsen, Geir verfasserin aut Eggen, Anne E. verfasserin aut Bikbov, Mukharram M. verfasserin aut Jonas, Jost B. 1958- verfasserin (DE-588)1028286732 (DE-627)730536823 (DE-576)37578537X aut Klaver, Caroline C. W. verfasserin aut Ramdas, Wishal D. verfasserin aut Khawaja, Anthony P. verfasserin aut Enthalten in Ophthalmology Amsterdam [u.a.] : Elsevier, 1978 130(2023), 9 vom: Sept., Seite 893-906 Online-Ressource (DE-627)320526941 (DE-600)2015287-5 (DE-576)121465691 1549-4713 nnns volume:130 year:2023 number:9 month:09 pages:893-906 extent:14 https://doi.org/10.1016/j.ophtha.2023.05.001 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0161642023003068 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 130 2023 9 9 893-906 14 2013 01 DE-16-250 4407601639 00 --%%-- --%%-- --%%-- --%%-- l01 15-11-23 2013 01 DE-16-250 00 s hd2023 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_29 2013 01 DE-16-250 03 s s_14 2013 01 DE-16-250 04 p (DE-627)1445785498 Jonas, Jost B. 2013 01 DE-16-250 04 k (DE-627)1416467416 Augenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_26
spelling	10.1016/j.ophtha.2023.05.001 doi (DE-627)1870336453 (DE-599)KXP1870336453 (OCoLC)1425209375 DE-627 ger DE-627 rda eng Vergroesen, Joëlle verfasserin (DE-588)1309912262 (DE-627)1870336844 aut Association of systemic medication use with Glaucoma and intraocular pressure the European Eye Epidemiology Consortium Joëlle E. Vergroesen, Alexander K. Schuster, Kelsey V. Stuart, Nigus G. Asefa, Audrey Cougnard-Grégoire, Cécile Delcourt, Cédric Schweitzer, Patrícia Barreto, Rita Coimbra, Paul J. Foster, Robert N. Luben, Norbert Pfeiffer, Julia V. Stingl, Toralf Kirsten, Franziska G. Rauscher, Kerstin Wirkner, Nomdo M. Jansonius, Louis Arnould, Catherine P. Creuzot-Garcher, Bruno H. Stricker, Christina Keskini, Fotis Topouzis, Geir Bertelsen, Anne E. Eggen, Mukharram M. Bikbov, Jost B. Jonas, Caroline C. W. Klaver, Wishal D. Ramdas, Anthony P. Khawaja, on behalf of the European Eye Epidemiology Consortium September 2023 14 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Online verfügbar: 6. Mai 2023, Artikelversion: 18. August 2023 Gesehen am 15.11.2023 Purpose - To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population. - Design - Meta-analysis of 11 population-based cohort studies of the European Eye Epidemiology Consortium. - Participants - The glaucoma analyses included 143 240 participants and the IOP analyses included 47 177 participants. - Methods - We examined associations of 4 categories of systemic medications—antihypertensive medications (β-blockers, diuretics, calcium channel blockers [CCBs], α-agonists, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers), lipid-lowering medications, antidepressants, and antidiabetic medications—with glaucoma prevalence and IOP. Glaucoma ascertainment and IOP measurement method were according to individual study protocols. Results of multivariable regression analyses of each study were pooled using random effects meta-analyses. Associations with antidiabetic medications were examined in participants with diabetes only. - Main Outcome Measures - Glaucoma prevalence and IOP. - Results - In the meta-analyses of our maximally adjusted multivariable models, use of CCBs was associated with a higher prevalence of glaucoma (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.08 to 1.39). This association was stronger for monotherapy of CCBs with direct cardiac effects (OR, 1.96; 95% CI, 1.23 to 3.12). No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with glaucoma. Use of systemic β-blockers was associated with a lower IOP (β coefficient, −0.33 mmHg; 95% CI, −0.57 to −0.08 mmHg). Monotherapy of both selective systemic β-blockers (β coefficient, −0.45 mmHg; 95% CI −0.74 to −0.16 mmHg) and nonselective systemic β-blockers (β coefficient, −0.54 mmHg; 95% CI, −0.94 to −0.15 mmHg) was associated with lower IOP. A suggestive association was found between use of high-ceiling diuretics and lower IOP (β coefficient, −0.30 mmHg; 95% CI, −0.47 to −0.14 mmHg) but not when used as monotherapy. No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with IOP. - Conclusions - We identified a potentially harmful association between use of CCBs and glaucoma prevalence. Additionally, we observed and quantified the association of lower IOP with systemic β-blocker use. Both findings potentially are important, given that patients with glaucoma frequently use systemic antihypertensive medications. Determining causality of the CCB association should be a research priority. - Financial Disclosure(s) - Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. Epidemiology Glaucoma Intraocular pressure Systemic medication Schuster, Alexander K. verfasserin aut Stuart, Kelsey V. verfasserin aut Asefa, Nigus G. verfasserin aut Cougnard-Grégoire, Audrey verfasserin aut Delcourt, Cécile verfasserin aut Schweitzer, Cédric verfasserin aut Barreto, Patrícia verfasserin aut Coimbra, Rita verfasserin aut Foster, Paul J. verfasserin aut Luben, Robert N. verfasserin aut Pfeiffer, Norbert verfasserin aut Stingl, Julia V. verfasserin aut Kirsten, Toralf verfasserin aut Rauscher, Franziska G. verfasserin aut Wirkner, Kerstin verfasserin aut Jansonius, Nomdo M. verfasserin aut Arnould, Louis verfasserin aut Creuzot-Garcher, Catherine P. verfasserin aut Stricker, Bruno H. verfasserin aut Keskini, Christina verfasserin aut Topouzis, Fotis verfasserin aut Bertelsen, Geir verfasserin aut Eggen, Anne E. verfasserin aut Bikbov, Mukharram M. verfasserin aut Jonas, Jost B. 1958- verfasserin (DE-588)1028286732 (DE-627)730536823 (DE-576)37578537X aut Klaver, Caroline C. W. verfasserin aut Ramdas, Wishal D. verfasserin aut Khawaja, Anthony P. verfasserin aut Enthalten in Ophthalmology Amsterdam [u.a.] : Elsevier, 1978 130(2023), 9 vom: Sept., Seite 893-906 Online-Ressource (DE-627)320526941 (DE-600)2015287-5 (DE-576)121465691 1549-4713 nnns volume:130 year:2023 number:9 month:09 pages:893-906 extent:14 https://doi.org/10.1016/j.ophtha.2023.05.001 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0161642023003068 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 130 2023 9 9 893-906 14 2013 01 DE-16-250 4407601639 00 --%%-- --%%-- --%%-- --%%-- l01 15-11-23 2013 01 DE-16-250 00 s hd2023 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_29 2013 01 DE-16-250 03 s s_14 2013 01 DE-16-250 04 p (DE-627)1445785498 Jonas, Jost B. 2013 01 DE-16-250 04 k (DE-627)1416467416 Augenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_26
allfields_unstemmed	10.1016/j.ophtha.2023.05.001 doi (DE-627)1870336453 (DE-599)KXP1870336453 (OCoLC)1425209375 DE-627 ger DE-627 rda eng Vergroesen, Joëlle verfasserin (DE-588)1309912262 (DE-627)1870336844 aut Association of systemic medication use with Glaucoma and intraocular pressure the European Eye Epidemiology Consortium Joëlle E. Vergroesen, Alexander K. Schuster, Kelsey V. Stuart, Nigus G. Asefa, Audrey Cougnard-Grégoire, Cécile Delcourt, Cédric Schweitzer, Patrícia Barreto, Rita Coimbra, Paul J. Foster, Robert N. Luben, Norbert Pfeiffer, Julia V. Stingl, Toralf Kirsten, Franziska G. Rauscher, Kerstin Wirkner, Nomdo M. Jansonius, Louis Arnould, Catherine P. Creuzot-Garcher, Bruno H. Stricker, Christina Keskini, Fotis Topouzis, Geir Bertelsen, Anne E. Eggen, Mukharram M. Bikbov, Jost B. Jonas, Caroline C. W. Klaver, Wishal D. Ramdas, Anthony P. Khawaja, on behalf of the European Eye Epidemiology Consortium September 2023 14 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Online verfügbar: 6. Mai 2023, Artikelversion: 18. August 2023 Gesehen am 15.11.2023 Purpose - To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population. - Design - Meta-analysis of 11 population-based cohort studies of the European Eye Epidemiology Consortium. - Participants - The glaucoma analyses included 143 240 participants and the IOP analyses included 47 177 participants. - Methods - We examined associations of 4 categories of systemic medications—antihypertensive medications (β-blockers, diuretics, calcium channel blockers [CCBs], α-agonists, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers), lipid-lowering medications, antidepressants, and antidiabetic medications—with glaucoma prevalence and IOP. Glaucoma ascertainment and IOP measurement method were according to individual study protocols. Results of multivariable regression analyses of each study were pooled using random effects meta-analyses. Associations with antidiabetic medications were examined in participants with diabetes only. - Main Outcome Measures - Glaucoma prevalence and IOP. - Results - In the meta-analyses of our maximally adjusted multivariable models, use of CCBs was associated with a higher prevalence of glaucoma (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.08 to 1.39). This association was stronger for monotherapy of CCBs with direct cardiac effects (OR, 1.96; 95% CI, 1.23 to 3.12). No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with glaucoma. Use of systemic β-blockers was associated with a lower IOP (β coefficient, −0.33 mmHg; 95% CI, −0.57 to −0.08 mmHg). Monotherapy of both selective systemic β-blockers (β coefficient, −0.45 mmHg; 95% CI −0.74 to −0.16 mmHg) and nonselective systemic β-blockers (β coefficient, −0.54 mmHg; 95% CI, −0.94 to −0.15 mmHg) was associated with lower IOP. A suggestive association was found between use of high-ceiling diuretics and lower IOP (β coefficient, −0.30 mmHg; 95% CI, −0.47 to −0.14 mmHg) but not when used as monotherapy. No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with IOP. - Conclusions - We identified a potentially harmful association between use of CCBs and glaucoma prevalence. Additionally, we observed and quantified the association of lower IOP with systemic β-blocker use. Both findings potentially are important, given that patients with glaucoma frequently use systemic antihypertensive medications. Determining causality of the CCB association should be a research priority. - Financial Disclosure(s) - Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. Epidemiology Glaucoma Intraocular pressure Systemic medication Schuster, Alexander K. verfasserin aut Stuart, Kelsey V. verfasserin aut Asefa, Nigus G. verfasserin aut Cougnard-Grégoire, Audrey verfasserin aut Delcourt, Cécile verfasserin aut Schweitzer, Cédric verfasserin aut Barreto, Patrícia verfasserin aut Coimbra, Rita verfasserin aut Foster, Paul J. verfasserin aut Luben, Robert N. verfasserin aut Pfeiffer, Norbert verfasserin aut Stingl, Julia V. verfasserin aut Kirsten, Toralf verfasserin aut Rauscher, Franziska G. verfasserin aut Wirkner, Kerstin verfasserin aut Jansonius, Nomdo M. verfasserin aut Arnould, Louis verfasserin aut Creuzot-Garcher, Catherine P. verfasserin aut Stricker, Bruno H. verfasserin aut Keskini, Christina verfasserin aut Topouzis, Fotis verfasserin aut Bertelsen, Geir verfasserin aut Eggen, Anne E. verfasserin aut Bikbov, Mukharram M. verfasserin aut Jonas, Jost B. 1958- verfasserin (DE-588)1028286732 (DE-627)730536823 (DE-576)37578537X aut Klaver, Caroline C. W. verfasserin aut Ramdas, Wishal D. verfasserin aut Khawaja, Anthony P. verfasserin aut Enthalten in Ophthalmology Amsterdam [u.a.] : Elsevier, 1978 130(2023), 9 vom: Sept., Seite 893-906 Online-Ressource (DE-627)320526941 (DE-600)2015287-5 (DE-576)121465691 1549-4713 nnns volume:130 year:2023 number:9 month:09 pages:893-906 extent:14 https://doi.org/10.1016/j.ophtha.2023.05.001 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0161642023003068 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 130 2023 9 9 893-906 14 2013 01 DE-16-250 4407601639 00 --%%-- --%%-- --%%-- --%%-- l01 15-11-23 2013 01 DE-16-250 00 s hd2023 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_29 2013 01 DE-16-250 03 s s_14 2013 01 DE-16-250 04 p (DE-627)1445785498 Jonas, Jost B. 2013 01 DE-16-250 04 k (DE-627)1416467416 Augenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_26
allfieldsGer	10.1016/j.ophtha.2023.05.001 doi (DE-627)1870336453 (DE-599)KXP1870336453 (OCoLC)1425209375 DE-627 ger DE-627 rda eng Vergroesen, Joëlle verfasserin (DE-588)1309912262 (DE-627)1870336844 aut Association of systemic medication use with Glaucoma and intraocular pressure the European Eye Epidemiology Consortium Joëlle E. Vergroesen, Alexander K. Schuster, Kelsey V. Stuart, Nigus G. Asefa, Audrey Cougnard-Grégoire, Cécile Delcourt, Cédric Schweitzer, Patrícia Barreto, Rita Coimbra, Paul J. Foster, Robert N. Luben, Norbert Pfeiffer, Julia V. Stingl, Toralf Kirsten, Franziska G. Rauscher, Kerstin Wirkner, Nomdo M. Jansonius, Louis Arnould, Catherine P. Creuzot-Garcher, Bruno H. Stricker, Christina Keskini, Fotis Topouzis, Geir Bertelsen, Anne E. Eggen, Mukharram M. Bikbov, Jost B. Jonas, Caroline C. W. Klaver, Wishal D. Ramdas, Anthony P. Khawaja, on behalf of the European Eye Epidemiology Consortium September 2023 14 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Online verfügbar: 6. Mai 2023, Artikelversion: 18. August 2023 Gesehen am 15.11.2023 Purpose - To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population. - Design - Meta-analysis of 11 population-based cohort studies of the European Eye Epidemiology Consortium. - Participants - The glaucoma analyses included 143 240 participants and the IOP analyses included 47 177 participants. - Methods - We examined associations of 4 categories of systemic medications—antihypertensive medications (β-blockers, diuretics, calcium channel blockers [CCBs], α-agonists, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers), lipid-lowering medications, antidepressants, and antidiabetic medications—with glaucoma prevalence and IOP. Glaucoma ascertainment and IOP measurement method were according to individual study protocols. Results of multivariable regression analyses of each study were pooled using random effects meta-analyses. Associations with antidiabetic medications were examined in participants with diabetes only. - Main Outcome Measures - Glaucoma prevalence and IOP. - Results - In the meta-analyses of our maximally adjusted multivariable models, use of CCBs was associated with a higher prevalence of glaucoma (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.08 to 1.39). This association was stronger for monotherapy of CCBs with direct cardiac effects (OR, 1.96; 95% CI, 1.23 to 3.12). No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with glaucoma. Use of systemic β-blockers was associated with a lower IOP (β coefficient, −0.33 mmHg; 95% CI, −0.57 to −0.08 mmHg). Monotherapy of both selective systemic β-blockers (β coefficient, −0.45 mmHg; 95% CI −0.74 to −0.16 mmHg) and nonselective systemic β-blockers (β coefficient, −0.54 mmHg; 95% CI, −0.94 to −0.15 mmHg) was associated with lower IOP. A suggestive association was found between use of high-ceiling diuretics and lower IOP (β coefficient, −0.30 mmHg; 95% CI, −0.47 to −0.14 mmHg) but not when used as monotherapy. No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with IOP. - Conclusions - We identified a potentially harmful association between use of CCBs and glaucoma prevalence. Additionally, we observed and quantified the association of lower IOP with systemic β-blocker use. Both findings potentially are important, given that patients with glaucoma frequently use systemic antihypertensive medications. Determining causality of the CCB association should be a research priority. - Financial Disclosure(s) - Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. Epidemiology Glaucoma Intraocular pressure Systemic medication Schuster, Alexander K. verfasserin aut Stuart, Kelsey V. verfasserin aut Asefa, Nigus G. verfasserin aut Cougnard-Grégoire, Audrey verfasserin aut Delcourt, Cécile verfasserin aut Schweitzer, Cédric verfasserin aut Barreto, Patrícia verfasserin aut Coimbra, Rita verfasserin aut Foster, Paul J. verfasserin aut Luben, Robert N. verfasserin aut Pfeiffer, Norbert verfasserin aut Stingl, Julia V. verfasserin aut Kirsten, Toralf verfasserin aut Rauscher, Franziska G. verfasserin aut Wirkner, Kerstin verfasserin aut Jansonius, Nomdo M. verfasserin aut Arnould, Louis verfasserin aut Creuzot-Garcher, Catherine P. verfasserin aut Stricker, Bruno H. verfasserin aut Keskini, Christina verfasserin aut Topouzis, Fotis verfasserin aut Bertelsen, Geir verfasserin aut Eggen, Anne E. verfasserin aut Bikbov, Mukharram M. verfasserin aut Jonas, Jost B. 1958- verfasserin (DE-588)1028286732 (DE-627)730536823 (DE-576)37578537X aut Klaver, Caroline C. W. verfasserin aut Ramdas, Wishal D. verfasserin aut Khawaja, Anthony P. verfasserin aut Enthalten in Ophthalmology Amsterdam [u.a.] : Elsevier, 1978 130(2023), 9 vom: Sept., Seite 893-906 Online-Ressource (DE-627)320526941 (DE-600)2015287-5 (DE-576)121465691 1549-4713 nnns volume:130 year:2023 number:9 month:09 pages:893-906 extent:14 https://doi.org/10.1016/j.ophtha.2023.05.001 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0161642023003068 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 130 2023 9 9 893-906 14 2013 01 DE-16-250 4407601639 00 --%%-- --%%-- --%%-- --%%-- l01 15-11-23 2013 01 DE-16-250 00 s hd2023 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_29 2013 01 DE-16-250 03 s s_14 2013 01 DE-16-250 04 p (DE-627)1445785498 Jonas, Jost B. 2013 01 DE-16-250 04 k (DE-627)1416467416 Augenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_26
allfieldsSound	10.1016/j.ophtha.2023.05.001 doi (DE-627)1870336453 (DE-599)KXP1870336453 (OCoLC)1425209375 DE-627 ger DE-627 rda eng Vergroesen, Joëlle verfasserin (DE-588)1309912262 (DE-627)1870336844 aut Association of systemic medication use with Glaucoma and intraocular pressure the European Eye Epidemiology Consortium Joëlle E. Vergroesen, Alexander K. Schuster, Kelsey V. Stuart, Nigus G. Asefa, Audrey Cougnard-Grégoire, Cécile Delcourt, Cédric Schweitzer, Patrícia Barreto, Rita Coimbra, Paul J. Foster, Robert N. Luben, Norbert Pfeiffer, Julia V. Stingl, Toralf Kirsten, Franziska G. Rauscher, Kerstin Wirkner, Nomdo M. Jansonius, Louis Arnould, Catherine P. Creuzot-Garcher, Bruno H. Stricker, Christina Keskini, Fotis Topouzis, Geir Bertelsen, Anne E. Eggen, Mukharram M. Bikbov, Jost B. Jonas, Caroline C. W. Klaver, Wishal D. Ramdas, Anthony P. Khawaja, on behalf of the European Eye Epidemiology Consortium September 2023 14 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Online verfügbar: 6. Mai 2023, Artikelversion: 18. August 2023 Gesehen am 15.11.2023 Purpose - To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population. - Design - Meta-analysis of 11 population-based cohort studies of the European Eye Epidemiology Consortium. - Participants - The glaucoma analyses included 143 240 participants and the IOP analyses included 47 177 participants. - Methods - We examined associations of 4 categories of systemic medications—antihypertensive medications (β-blockers, diuretics, calcium channel blockers [CCBs], α-agonists, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers), lipid-lowering medications, antidepressants, and antidiabetic medications—with glaucoma prevalence and IOP. Glaucoma ascertainment and IOP measurement method were according to individual study protocols. Results of multivariable regression analyses of each study were pooled using random effects meta-analyses. Associations with antidiabetic medications were examined in participants with diabetes only. - Main Outcome Measures - Glaucoma prevalence and IOP. - Results - In the meta-analyses of our maximally adjusted multivariable models, use of CCBs was associated with a higher prevalence of glaucoma (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.08 to 1.39). This association was stronger for monotherapy of CCBs with direct cardiac effects (OR, 1.96; 95% CI, 1.23 to 3.12). No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with glaucoma. Use of systemic β-blockers was associated with a lower IOP (β coefficient, −0.33 mmHg; 95% CI, −0.57 to −0.08 mmHg). Monotherapy of both selective systemic β-blockers (β coefficient, −0.45 mmHg; 95% CI −0.74 to −0.16 mmHg) and nonselective systemic β-blockers (β coefficient, −0.54 mmHg; 95% CI, −0.94 to −0.15 mmHg) was associated with lower IOP. A suggestive association was found between use of high-ceiling diuretics and lower IOP (β coefficient, −0.30 mmHg; 95% CI, −0.47 to −0.14 mmHg) but not when used as monotherapy. No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with IOP. - Conclusions - We identified a potentially harmful association between use of CCBs and glaucoma prevalence. Additionally, we observed and quantified the association of lower IOP with systemic β-blocker use. Both findings potentially are important, given that patients with glaucoma frequently use systemic antihypertensive medications. Determining causality of the CCB association should be a research priority. - Financial Disclosure(s) - Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. Epidemiology Glaucoma Intraocular pressure Systemic medication Schuster, Alexander K. verfasserin aut Stuart, Kelsey V. verfasserin aut Asefa, Nigus G. verfasserin aut Cougnard-Grégoire, Audrey verfasserin aut Delcourt, Cécile verfasserin aut Schweitzer, Cédric verfasserin aut Barreto, Patrícia verfasserin aut Coimbra, Rita verfasserin aut Foster, Paul J. verfasserin aut Luben, Robert N. verfasserin aut Pfeiffer, Norbert verfasserin aut Stingl, Julia V. verfasserin aut Kirsten, Toralf verfasserin aut Rauscher, Franziska G. verfasserin aut Wirkner, Kerstin verfasserin aut Jansonius, Nomdo M. verfasserin aut Arnould, Louis verfasserin aut Creuzot-Garcher, Catherine P. verfasserin aut Stricker, Bruno H. verfasserin aut Keskini, Christina verfasserin aut Topouzis, Fotis verfasserin aut Bertelsen, Geir verfasserin aut Eggen, Anne E. verfasserin aut Bikbov, Mukharram M. verfasserin aut Jonas, Jost B. 1958- verfasserin (DE-588)1028286732 (DE-627)730536823 (DE-576)37578537X aut Klaver, Caroline C. W. verfasserin aut Ramdas, Wishal D. verfasserin aut Khawaja, Anthony P. verfasserin aut Enthalten in Ophthalmology Amsterdam [u.a.] : Elsevier, 1978 130(2023), 9 vom: Sept., Seite 893-906 Online-Ressource (DE-627)320526941 (DE-600)2015287-5 (DE-576)121465691 1549-4713 nnns volume:130 year:2023 number:9 month:09 pages:893-906 extent:14 https://doi.org/10.1016/j.ophtha.2023.05.001 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0161642023003068 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 130 2023 9 9 893-906 14 2013 01 DE-16-250 4407601639 00 --%%-- --%%-- --%%-- --%%-- l01 15-11-23 2013 01 DE-16-250 00 s hd2023 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_29 2013 01 DE-16-250 03 s s_14 2013 01 DE-16-250 04 p (DE-627)1445785498 Jonas, Jost B. 2013 01 DE-16-250 04 k (DE-627)1416467416 Augenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_26
language	English
source	Enthalten in Ophthalmology 130(2023), 9 vom: Sept., Seite 893-906 volume:130 year:2023 number:9 month:09 pages:893-906 extent:14
sourceStr	Enthalten in Ophthalmology 130(2023), 9 vom: Sept., Seite 893-906 volume:130 year:2023 number:9 month:09 pages:893-906 extent:14
format_phy_str_mv	Article
building	2013:0
institution	findex.gbv.de
selectbib_iln_str_mv	2013@01
topic_facet	Epidemiology Glaucoma Intraocular pressure Systemic medication
sw_local_iln_str_mv	2013:hd2023 DE-16-250:hd2023 2013:wissenschaftlicher Artikel (Zeitschrift) DE-16-250:wissenschaftlicher Artikel (Zeitschrift) 2013:per_29 DE-16-250:per_29 2013:s_14 DE-16-250:s_14 2013:Jonas, Jost B. DE-16-250:Jonas, Jost B. 2013:Augenklinik DE-16-250:Augenklinik 2013:Verfasser DE-16-250:Verfasser 2013:pos_26 DE-16-250:pos_26
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container_title	Ophthalmology
authorswithroles_txt_mv	Vergroesen, Joëlle @@aut@@ Schuster, Alexander K. @@aut@@ Stuart, Kelsey V. @@aut@@ Asefa, Nigus G. @@aut@@ Cougnard-Grégoire, Audrey @@aut@@ Delcourt, Cécile @@aut@@ Schweitzer, Cédric @@aut@@ Barreto, Patrícia @@aut@@ Coimbra, Rita @@aut@@ Foster, Paul J. @@aut@@ Luben, Robert N. @@aut@@ Pfeiffer, Norbert @@aut@@ Stingl, Julia V. @@aut@@ Kirsten, Toralf @@aut@@ Rauscher, Franziska G. @@aut@@ Wirkner, Kerstin @@aut@@ Jansonius, Nomdo M. @@aut@@ Arnould, Louis @@aut@@ Creuzot-Garcher, Catherine P. @@aut@@ Stricker, Bruno H. @@aut@@ Keskini, Christina @@aut@@ Topouzis, Fotis @@aut@@ Bertelsen, Geir @@aut@@ Eggen, Anne E. @@aut@@ Bikbov, Mukharram M. @@aut@@ Jonas, Jost B. @@aut@@ Klaver, Caroline C. W. @@aut@@ Ramdas, Wishal D. @@aut@@ Khawaja, Anthony P. @@aut@@
publishDateDaySort_date	2023-09-01T00:00:00Z
hierarchy_top_id	320526941
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language_de	englisch
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Glaucoma ascertainment and IOP measurement method were according to individual study protocols. Results of multivariable regression analyses of each study were pooled using random effects meta-analyses. Associations with antidiabetic medications were examined in participants with diabetes only. - Main Outcome Measures - Glaucoma prevalence and IOP. - Results - In the meta-analyses of our maximally adjusted multivariable models, use of CCBs was associated with a higher prevalence of glaucoma (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.08 to 1.39). This association was stronger for monotherapy of CCBs with direct cardiac effects (OR, 1.96; 95% CI, 1.23 to 3.12). No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with glaucoma. Use of systemic β-blockers was associated with a lower IOP (β coefficient, −0.33 mmHg; 95% CI, −0.57 to −0.08 mmHg). 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topic_title	2013 01 DE-16-250 00 s hd2023 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_29 2013 01 DE-16-250 03 s s_14 2013 01 DE-16-250 04 p (DE-627)1445785498 Jonas, Jost B. 2013 01 DE-16-250 04 k (DE-627)1416467416 Augenklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_26 Association of systemic medication use with Glaucoma and intraocular pressure the European Eye Epidemiology Consortium Joëlle E. Vergroesen, Alexander K. Schuster, Kelsey V. Stuart, Nigus G. Asefa, Audrey Cougnard-Grégoire, Cécile Delcourt, Cédric Schweitzer, Patrícia Barreto, Rita Coimbra, Paul J. Foster, Robert N. Luben, Norbert Pfeiffer, Julia V. Stingl, Toralf Kirsten, Franziska G. Rauscher, Kerstin Wirkner, Nomdo M. Jansonius, Louis Arnould, Catherine P. Creuzot-Garcher, Bruno H. Stricker, Christina Keskini, Fotis Topouzis, Geir Bertelsen, Anne E. Eggen, Mukharram M. Bikbov, Jost B. Jonas, Caroline C. W. Klaver, Wishal D. Ramdas, Anthony P. Khawaja, on behalf of the European Eye Epidemiology Consortium Epidemiology Glaucoma Intraocular pressure Systemic medication
topic	misc Epidemiology misc Glaucoma misc Intraocular pressure misc Systemic medication 2013 hd2023 2013 wissenschaftlicher Artikel (Zeitschrift) 2013 per_29 2013 s_14 2013 Jonas, Jost B. 2013 Augenklinik 2013 Verfasser 2013 pos_26
topic_unstemmed	misc Epidemiology misc Glaucoma misc Intraocular pressure misc Systemic medication 2013 hd2023 2013 wissenschaftlicher Artikel (Zeitschrift) 2013 per_29 2013 s_14 2013 Jonas, Jost B. 2013 Augenklinik 2013 Verfasser 2013 pos_26
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title	Association of systemic medication use with Glaucoma and intraocular pressure the European Eye Epidemiology Consortium
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title_full	Association of systemic medication use with Glaucoma and intraocular pressure the European Eye Epidemiology Consortium Joëlle E. Vergroesen, Alexander K. Schuster, Kelsey V. Stuart, Nigus G. Asefa, Audrey Cougnard-Grégoire, Cécile Delcourt, Cédric Schweitzer, Patrícia Barreto, Rita Coimbra, Paul J. Foster, Robert N. Luben, Norbert Pfeiffer, Julia V. Stingl, Toralf Kirsten, Franziska G. Rauscher, Kerstin Wirkner, Nomdo M. Jansonius, Louis Arnould, Catherine P. Creuzot-Garcher, Bruno H. Stricker, Christina Keskini, Fotis Topouzis, Geir Bertelsen, Anne E. Eggen, Mukharram M. Bikbov, Jost B. Jonas, Caroline C. W. Klaver, Wishal D. Ramdas, Anthony P. Khawaja, on behalf of the European Eye Epidemiology Consortium
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title_sort	association of systemic medication use with glaucoma and intraocular pressurethe european eye epidemiology consortium
title_auth	Association of systemic medication use with Glaucoma and intraocular pressure the European Eye Epidemiology Consortium
abstract	Purpose - To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population. - Design - Meta-analysis of 11 population-based cohort studies of the European Eye Epidemiology Consortium. - Participants - The glaucoma analyses included 143 240 participants and the IOP analyses included 47 177 participants. - Methods - We examined associations of 4 categories of systemic medications—antihypertensive medications (β-blockers, diuretics, calcium channel blockers [CCBs], α-agonists, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers), lipid-lowering medications, antidepressants, and antidiabetic medications—with glaucoma prevalence and IOP. Glaucoma ascertainment and IOP measurement method were according to individual study protocols. Results of multivariable regression analyses of each study were pooled using random effects meta-analyses. Associations with antidiabetic medications were examined in participants with diabetes only. - Main Outcome Measures - Glaucoma prevalence and IOP. - Results - In the meta-analyses of our maximally adjusted multivariable models, use of CCBs was associated with a higher prevalence of glaucoma (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.08 to 1.39). This association was stronger for monotherapy of CCBs with direct cardiac effects (OR, 1.96; 95% CI, 1.23 to 3.12). No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with glaucoma. Use of systemic β-blockers was associated with a lower IOP (β coefficient, −0.33 mmHg; 95% CI, −0.57 to −0.08 mmHg). Monotherapy of both selective systemic β-blockers (β coefficient, −0.45 mmHg; 95% CI −0.74 to −0.16 mmHg) and nonselective systemic β-blockers (β coefficient, −0.54 mmHg; 95% CI, −0.94 to −0.15 mmHg) was associated with lower IOP. A suggestive association was found between use of high-ceiling diuretics and lower IOP (β coefficient, −0.30 mmHg; 95% CI, −0.47 to −0.14 mmHg) but not when used as monotherapy. No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with IOP. - Conclusions - We identified a potentially harmful association between use of CCBs and glaucoma prevalence. Additionally, we observed and quantified the association of lower IOP with systemic β-blocker use. Both findings potentially are important, given that patients with glaucoma frequently use systemic antihypertensive medications. Determining causality of the CCB association should be a research priority. - Financial Disclosure(s) - Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. Online verfügbar: 6. Mai 2023, Artikelversion: 18. August 2023 Gesehen am 15.11.2023
abstractGer	Purpose - To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population. - Design - Meta-analysis of 11 population-based cohort studies of the European Eye Epidemiology Consortium. - Participants - The glaucoma analyses included 143 240 participants and the IOP analyses included 47 177 participants. - Methods - We examined associations of 4 categories of systemic medications—antihypertensive medications (β-blockers, diuretics, calcium channel blockers [CCBs], α-agonists, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers), lipid-lowering medications, antidepressants, and antidiabetic medications—with glaucoma prevalence and IOP. Glaucoma ascertainment and IOP measurement method were according to individual study protocols. Results of multivariable regression analyses of each study were pooled using random effects meta-analyses. Associations with antidiabetic medications were examined in participants with diabetes only. - Main Outcome Measures - Glaucoma prevalence and IOP. - Results - In the meta-analyses of our maximally adjusted multivariable models, use of CCBs was associated with a higher prevalence of glaucoma (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.08 to 1.39). This association was stronger for monotherapy of CCBs with direct cardiac effects (OR, 1.96; 95% CI, 1.23 to 3.12). No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with glaucoma. Use of systemic β-blockers was associated with a lower IOP (β coefficient, −0.33 mmHg; 95% CI, −0.57 to −0.08 mmHg). Monotherapy of both selective systemic β-blockers (β coefficient, −0.45 mmHg; 95% CI −0.74 to −0.16 mmHg) and nonselective systemic β-blockers (β coefficient, −0.54 mmHg; 95% CI, −0.94 to −0.15 mmHg) was associated with lower IOP. A suggestive association was found between use of high-ceiling diuretics and lower IOP (β coefficient, −0.30 mmHg; 95% CI, −0.47 to −0.14 mmHg) but not when used as monotherapy. No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with IOP. - Conclusions - We identified a potentially harmful association between use of CCBs and glaucoma prevalence. Additionally, we observed and quantified the association of lower IOP with systemic β-blocker use. Both findings potentially are important, given that patients with glaucoma frequently use systemic antihypertensive medications. Determining causality of the CCB association should be a research priority. - Financial Disclosure(s) - Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. Online verfügbar: 6. Mai 2023, Artikelversion: 18. August 2023 Gesehen am 15.11.2023
abstract_unstemmed	Purpose - To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population. - Design - Meta-analysis of 11 population-based cohort studies of the European Eye Epidemiology Consortium. - Participants - The glaucoma analyses included 143 240 participants and the IOP analyses included 47 177 participants. - Methods - We examined associations of 4 categories of systemic medications—antihypertensive medications (β-blockers, diuretics, calcium channel blockers [CCBs], α-agonists, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers), lipid-lowering medications, antidepressants, and antidiabetic medications—with glaucoma prevalence and IOP. Glaucoma ascertainment and IOP measurement method were according to individual study protocols. Results of multivariable regression analyses of each study were pooled using random effects meta-analyses. Associations with antidiabetic medications were examined in participants with diabetes only. - Main Outcome Measures - Glaucoma prevalence and IOP. - Results - In the meta-analyses of our maximally adjusted multivariable models, use of CCBs was associated with a higher prevalence of glaucoma (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.08 to 1.39). This association was stronger for monotherapy of CCBs with direct cardiac effects (OR, 1.96; 95% CI, 1.23 to 3.12). No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with glaucoma. Use of systemic β-blockers was associated with a lower IOP (β coefficient, −0.33 mmHg; 95% CI, −0.57 to −0.08 mmHg). Monotherapy of both selective systemic β-blockers (β coefficient, −0.45 mmHg; 95% CI −0.74 to −0.16 mmHg) and nonselective systemic β-blockers (β coefficient, −0.54 mmHg; 95% CI, −0.94 to −0.15 mmHg) was associated with lower IOP. A suggestive association was found between use of high-ceiling diuretics and lower IOP (β coefficient, −0.30 mmHg; 95% CI, −0.47 to −0.14 mmHg) but not when used as monotherapy. No other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were associated with IOP. - Conclusions - We identified a potentially harmful association between use of CCBs and glaucoma prevalence. Additionally, we observed and quantified the association of lower IOP with systemic β-blocker use. Both findings potentially are important, given that patients with glaucoma frequently use systemic antihypertensive medications. Determining causality of the CCB association should be a research priority. - Financial Disclosure(s) - Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. Online verfügbar: 6. Mai 2023, Artikelversion: 18. August 2023 Gesehen am 15.11.2023
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container_issue	9
title_short	Association of systemic medication use with Glaucoma and intraocular pressure
url	https://doi.org/10.1016/j.ophtha.2023.05.001 https://www.sciencedirect.com/science/article/pii/S0161642023003068
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author2	Schuster, Alexander K. Stuart, Kelsey V. Asefa, Nigus G. Cougnard-Grégoire, Audrey Delcourt, Cécile Schweitzer, Cédric Barreto, Patrícia Coimbra, Rita Foster, Paul J. Luben, Robert N. Pfeiffer, Norbert Stingl, Julia V. Kirsten, Toralf Rauscher, Franziska G. Wirkner, Kerstin Jansonius, Nomdo M. Arnould, Louis Creuzot-Garcher, Catherine P. Stricker, Bruno H. Keskini, Christina Topouzis, Fotis Bertelsen, Geir Eggen, Anne E. Bikbov, Mukharram M. Jonas, Jost B. 1958- Klaver, Caroline C. W. Ramdas, Wishal D. Khawaja, Anthony P.
author2Str	Schuster, Alexander K. Stuart, Kelsey V. Asefa, Nigus G. Cougnard-Grégoire, Audrey Delcourt, Cécile Schweitzer, Cédric Barreto, Patrícia Coimbra, Rita Foster, Paul J. Luben, Robert N. Pfeiffer, Norbert Stingl, Julia V. Kirsten, Toralf Rauscher, Franziska G. Wirkner, Kerstin Jansonius, Nomdo M. Arnould, Louis Creuzot-Garcher, Catherine P. Stricker, Bruno H. Keskini, Christina Topouzis, Fotis Bertelsen, Geir Eggen, Anne E. Bikbov, Mukharram M. Jonas, Jost B. 1958- Klaver, Caroline C. W. Ramdas, Wishal D. Khawaja, Anthony P.
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GND_str_mv	Vergroesen, J. E. Vergroesen, Joëlle E. Vergroesen, Joëlle Jonas, Jost Jonas, Jonas B. Jonas, Jost Bruno Jonas, JB Jonass, Jost B. Jonas, J. B. Jonas, JostB. Jonas, Jost B.
GND_txt_mv	Vergroesen, J. E. Vergroesen, Joëlle E. Vergroesen, Joëlle Jonas, Jost Jonas, Jonas B. Jonas, Jost Bruno Jonas, JB Jonass, Jost B. Jonas, J. B. Jonas, JostB. Jonas, Jost B.
GND_txtF_mv	Vergroesen, J. E. Vergroesen, Joëlle E. Vergroesen, Joëlle Jonas, Jost Jonas, Jonas B. Jonas, Jost Bruno Jonas, JB Jonass, Jost B. Jonas, J. B. Jonas, JostB. Jonas, Jost B.
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doi_str	10.1016/j.ophtha.2023.05.001
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up_date	2024-07-04T10:11:08.699Z
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Association of systemic medication use with Glaucoma and intraocular pressure : the European Eye Epidemiology Consortium

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