Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma
Single-nucleotide polymorphisms in different DNA-repair genes are reported to modulate risk of various cancers including melanoma. We genotyped DNA from 1186 melanoma patients and 1280 healthy controls for 13 different polymorphisms in eight DNA-repair genes. Data analyses showed that none of the po...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Figl, Adina - 1975- [verfasserIn] Scherer, Dominique - 1978- [verfasserIn] Nagore, Eduardo [verfasserIn] Lorenzo Bermejo, Justo - 1972- [verfasserIn] Botella-Estrada, Rafael [verfasserIn] Gast, Andreas [verfasserIn] Thirumaran, Ranjit Kumar - 1978- [verfasserIn] Planelles, Dolores [verfasserIn] Hemminki, Kari - 1947- [verfasserIn] Schadendorf, Dirk - 1960- [verfasserIn] Kumar, Rajiv - 1955- [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
26 June 2010 |
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| Schlagwörter: |
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| Anmerkung: |
Gesehen am 04.12.2023 |
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| Umfang: |
9 |
| Übergeordnetes Werk: |
Enthalten in: Mutation research. Genetic toxicology and environmental mutagenesis - Amsterdam [u.a.] : Elsevier Science, 1997, 702(2010), 1 vom: Sept., Seite 8-16 |
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| Übergeordnetes Werk: |
volume:702 ; year:2010 ; number:1 ; month:09 ; pages:8-16 ; extent:9 |
| Links: |
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| DOI / URN: |
10.1016/j.mrgentox.2010.06.011 |
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| Katalog-ID: |
1871820847 |
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| 245 | 1 | 0 | |a Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma |c Adina Figl, Dominique Scherer, Eduardo Nagore, Justo Lorenzo Bermejo, Rafael Botella-Estrada, Andreas Gast, Ranjit K. Thirumaran, Dolores Planelles, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar |
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| 520 | |a Single-nucleotide polymorphisms in different DNA-repair genes are reported to modulate risk of various cancers including melanoma. We genotyped DNA from 1186 melanoma patients and 1280 healthy controls for 13 different polymorphisms in eight DNA-repair genes. Data analyses showed that none of the polymorphisms except T241M XRCC3 was associated with an increased risk for cutaneous melanoma. Carriers of the variant alleles were associated with a decreased risk (OR 0.83; 95% CI, 0.79-0.98). Three additional polymorphisms together with T241M XRCC3 that tagged the entire gene region and the neighbouring genes KLC1, ZFYVE21 and PPP1R13B were not associated with the disease risk; neither were the inferred haplotypes. Imputation showed association of comparable magnitude with 11 non-genotyped neighbouring polymorphisms. Finally, the combination of results for all polymorphisms genotyped in the present study with published data suggests that none of the investigated polymorphisms was associated with melanoma susceptibility. We conclude that 13 non-synonymous polymorphisms in eight DNA-repair genes that are frequently investigated with respect to modulation of cancer risk in populations are not associated with susceptibility to cutaneous melanoma. | ||
| 650 | 4 | |a DNA Repair | |
| 650 | 4 | |a DNA-Binding Proteins | |
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| 650 | 4 | |a Kinesins | |
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26 June 2010 |
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2010 |
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10.1016/j.mrgentox.2010.06.011 doi (DE-627)1871820847 (DE-599)KXP1871820847 (OCoLC)1425872960 DE-627 ger DE-627 rda eng Figl, Adina 1975- verfasserin (DE-588)1146398816 (DE-627)1005834245 (DE-576)186024819 aut Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma Adina Figl, Dominique Scherer, Eduardo Nagore, Justo Lorenzo Bermejo, Rafael Botella-Estrada, Andreas Gast, Ranjit K. Thirumaran, Dolores Planelles, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar 26 June 2010 9 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 04.12.2023 Single-nucleotide polymorphisms in different DNA-repair genes are reported to modulate risk of various cancers including melanoma. We genotyped DNA from 1186 melanoma patients and 1280 healthy controls for 13 different polymorphisms in eight DNA-repair genes. Data analyses showed that none of the polymorphisms except T241M XRCC3 was associated with an increased risk for cutaneous melanoma. Carriers of the variant alleles were associated with a decreased risk (OR 0.83; 95% CI, 0.79-0.98). Three additional polymorphisms together with T241M XRCC3 that tagged the entire gene region and the neighbouring genes KLC1, ZFYVE21 and PPP1R13B were not associated with the disease risk; neither were the inferred haplotypes. Imputation showed association of comparable magnitude with 11 non-genotyped neighbouring polymorphisms. Finally, the combination of results for all polymorphisms genotyped in the present study with published data suggests that none of the investigated polymorphisms was associated with melanoma susceptibility. We conclude that 13 non-synonymous polymorphisms in eight DNA-repair genes that are frequently investigated with respect to modulation of cancer risk in populations are not associated with susceptibility to cutaneous melanoma. DNA Repair DNA-Binding Proteins Female Humans Kinesins Male Melanoma Polymorphism, Single Nucleotide Skin Neoplasms Scherer, Dominique 1978- verfasserin (DE-588)140126090 (DE-627)616036647 (DE-576)314697233 aut Nagore, Eduardo verfasserin (DE-588)1256183237 (DE-627)1800355742 aut Lorenzo Bermejo, Justo 1972- verfasserin (DE-588)124754619 (DE-627)706705572 (DE-576)294483632 aut Botella-Estrada, Rafael verfasserin aut Gast, Andreas verfasserin (DE-588)1226448496 (DE-627)1747463841 aut Thirumaran, Ranjit Kumar 1978- verfasserin (DE-588)132214466 (DE-627)519239571 (DE-576)299010074 aut Planelles, Dolores verfasserin aut Hemminki, Kari 1947- verfasserin (DE-588)1150735872 (DE-627)1010964402 (DE-576)172043751 aut Schadendorf, Dirk 1960- verfasserin (DE-588)11142576X (DE-627)499566076 (DE-576)289702275 aut Kumar, Rajiv 1955- verfasserin (DE-588)1164253425 (DE-627)1028811942 (DE-576)508469805 aut Enthalten in Mutation research. Genetic toxicology and environmental mutagenesis Amsterdam [u.a.] : Elsevier Science, 1997 702(2010), 1 vom: Sept., Seite 8-16 Online-Ressource (DE-627)503327336 (DE-600)2210272-3 (DE-576)25588480X 1388-2120 nnns volume:702 year:2010 number:1 month:09 pages:8-16 extent:9 https://doi.org/10.1016/j.mrgentox.2010.06.011 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S1383571810002226?via%3Dihub Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 702 2010 1 9 8-16 9 2013 01 DE-16-250 4425003594 00 --%%-- --%%-- --%%-- --%%-- l01 04-12-23 2013 01 DE-16-250 00 s hd2010 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_11 2013 01 DE-16-250 03 s s_9 2013 01 DE-16-250 04 p (DE-627)1742696414 Figl, Adina 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1497906962 Scherer, Dominique 2013 01 DE-16-250 05 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1462354653 Lorenzo Bermejo, Justo 2013 01 DE-16-250 06 k (DE-627)1416741593 Institut für Medizinische Biometrie und Informatik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 2013 01 DE-16-250 07 p (DE-627)1747463884 Gast, Andreas 2013 01 DE-16-250 07 k (DE-627)1416535500 Fakultät für Biowissenschaften 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_6 2013 01 DE-16-250 08 p (DE-627)1578469856 Kumar, Rajiv 2013 01 DE-16-250 08 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_11 |
| spelling |
10.1016/j.mrgentox.2010.06.011 doi (DE-627)1871820847 (DE-599)KXP1871820847 (OCoLC)1425872960 DE-627 ger DE-627 rda eng Figl, Adina 1975- verfasserin (DE-588)1146398816 (DE-627)1005834245 (DE-576)186024819 aut Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma Adina Figl, Dominique Scherer, Eduardo Nagore, Justo Lorenzo Bermejo, Rafael Botella-Estrada, Andreas Gast, Ranjit K. Thirumaran, Dolores Planelles, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar 26 June 2010 9 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 04.12.2023 Single-nucleotide polymorphisms in different DNA-repair genes are reported to modulate risk of various cancers including melanoma. We genotyped DNA from 1186 melanoma patients and 1280 healthy controls for 13 different polymorphisms in eight DNA-repair genes. Data analyses showed that none of the polymorphisms except T241M XRCC3 was associated with an increased risk for cutaneous melanoma. Carriers of the variant alleles were associated with a decreased risk (OR 0.83; 95% CI, 0.79-0.98). Three additional polymorphisms together with T241M XRCC3 that tagged the entire gene region and the neighbouring genes KLC1, ZFYVE21 and PPP1R13B were not associated with the disease risk; neither were the inferred haplotypes. Imputation showed association of comparable magnitude with 11 non-genotyped neighbouring polymorphisms. Finally, the combination of results for all polymorphisms genotyped in the present study with published data suggests that none of the investigated polymorphisms was associated with melanoma susceptibility. We conclude that 13 non-synonymous polymorphisms in eight DNA-repair genes that are frequently investigated with respect to modulation of cancer risk in populations are not associated with susceptibility to cutaneous melanoma. DNA Repair DNA-Binding Proteins Female Humans Kinesins Male Melanoma Polymorphism, Single Nucleotide Skin Neoplasms Scherer, Dominique 1978- verfasserin (DE-588)140126090 (DE-627)616036647 (DE-576)314697233 aut Nagore, Eduardo verfasserin (DE-588)1256183237 (DE-627)1800355742 aut Lorenzo Bermejo, Justo 1972- verfasserin (DE-588)124754619 (DE-627)706705572 (DE-576)294483632 aut Botella-Estrada, Rafael verfasserin aut Gast, Andreas verfasserin (DE-588)1226448496 (DE-627)1747463841 aut Thirumaran, Ranjit Kumar 1978- verfasserin (DE-588)132214466 (DE-627)519239571 (DE-576)299010074 aut Planelles, Dolores verfasserin aut Hemminki, Kari 1947- verfasserin (DE-588)1150735872 (DE-627)1010964402 (DE-576)172043751 aut Schadendorf, Dirk 1960- verfasserin (DE-588)11142576X (DE-627)499566076 (DE-576)289702275 aut Kumar, Rajiv 1955- verfasserin (DE-588)1164253425 (DE-627)1028811942 (DE-576)508469805 aut Enthalten in Mutation research. Genetic toxicology and environmental mutagenesis Amsterdam [u.a.] : Elsevier Science, 1997 702(2010), 1 vom: Sept., Seite 8-16 Online-Ressource (DE-627)503327336 (DE-600)2210272-3 (DE-576)25588480X 1388-2120 nnns volume:702 year:2010 number:1 month:09 pages:8-16 extent:9 https://doi.org/10.1016/j.mrgentox.2010.06.011 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S1383571810002226?via%3Dihub Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 702 2010 1 9 8-16 9 2013 01 DE-16-250 4425003594 00 --%%-- --%%-- --%%-- --%%-- l01 04-12-23 2013 01 DE-16-250 00 s hd2010 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_11 2013 01 DE-16-250 03 s s_9 2013 01 DE-16-250 04 p (DE-627)1742696414 Figl, Adina 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1497906962 Scherer, Dominique 2013 01 DE-16-250 05 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1462354653 Lorenzo Bermejo, Justo 2013 01 DE-16-250 06 k (DE-627)1416741593 Institut für Medizinische Biometrie und Informatik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 2013 01 DE-16-250 07 p (DE-627)1747463884 Gast, Andreas 2013 01 DE-16-250 07 k (DE-627)1416535500 Fakultät für Biowissenschaften 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_6 2013 01 DE-16-250 08 p (DE-627)1578469856 Kumar, Rajiv 2013 01 DE-16-250 08 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_11 |
| allfields_unstemmed |
10.1016/j.mrgentox.2010.06.011 doi (DE-627)1871820847 (DE-599)KXP1871820847 (OCoLC)1425872960 DE-627 ger DE-627 rda eng Figl, Adina 1975- verfasserin (DE-588)1146398816 (DE-627)1005834245 (DE-576)186024819 aut Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma Adina Figl, Dominique Scherer, Eduardo Nagore, Justo Lorenzo Bermejo, Rafael Botella-Estrada, Andreas Gast, Ranjit K. Thirumaran, Dolores Planelles, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar 26 June 2010 9 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 04.12.2023 Single-nucleotide polymorphisms in different DNA-repair genes are reported to modulate risk of various cancers including melanoma. We genotyped DNA from 1186 melanoma patients and 1280 healthy controls for 13 different polymorphisms in eight DNA-repair genes. Data analyses showed that none of the polymorphisms except T241M XRCC3 was associated with an increased risk for cutaneous melanoma. Carriers of the variant alleles were associated with a decreased risk (OR 0.83; 95% CI, 0.79-0.98). Three additional polymorphisms together with T241M XRCC3 that tagged the entire gene region and the neighbouring genes KLC1, ZFYVE21 and PPP1R13B were not associated with the disease risk; neither were the inferred haplotypes. Imputation showed association of comparable magnitude with 11 non-genotyped neighbouring polymorphisms. Finally, the combination of results for all polymorphisms genotyped in the present study with published data suggests that none of the investigated polymorphisms was associated with melanoma susceptibility. We conclude that 13 non-synonymous polymorphisms in eight DNA-repair genes that are frequently investigated with respect to modulation of cancer risk in populations are not associated with susceptibility to cutaneous melanoma. DNA Repair DNA-Binding Proteins Female Humans Kinesins Male Melanoma Polymorphism, Single Nucleotide Skin Neoplasms Scherer, Dominique 1978- verfasserin (DE-588)140126090 (DE-627)616036647 (DE-576)314697233 aut Nagore, Eduardo verfasserin (DE-588)1256183237 (DE-627)1800355742 aut Lorenzo Bermejo, Justo 1972- verfasserin (DE-588)124754619 (DE-627)706705572 (DE-576)294483632 aut Botella-Estrada, Rafael verfasserin aut Gast, Andreas verfasserin (DE-588)1226448496 (DE-627)1747463841 aut Thirumaran, Ranjit Kumar 1978- verfasserin (DE-588)132214466 (DE-627)519239571 (DE-576)299010074 aut Planelles, Dolores verfasserin aut Hemminki, Kari 1947- verfasserin (DE-588)1150735872 (DE-627)1010964402 (DE-576)172043751 aut Schadendorf, Dirk 1960- verfasserin (DE-588)11142576X (DE-627)499566076 (DE-576)289702275 aut Kumar, Rajiv 1955- verfasserin (DE-588)1164253425 (DE-627)1028811942 (DE-576)508469805 aut Enthalten in Mutation research. Genetic toxicology and environmental mutagenesis Amsterdam [u.a.] : Elsevier Science, 1997 702(2010), 1 vom: Sept., Seite 8-16 Online-Ressource (DE-627)503327336 (DE-600)2210272-3 (DE-576)25588480X 1388-2120 nnns volume:702 year:2010 number:1 month:09 pages:8-16 extent:9 https://doi.org/10.1016/j.mrgentox.2010.06.011 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S1383571810002226?via%3Dihub Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 702 2010 1 9 8-16 9 2013 01 DE-16-250 4425003594 00 --%%-- --%%-- --%%-- --%%-- l01 04-12-23 2013 01 DE-16-250 00 s hd2010 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_11 2013 01 DE-16-250 03 s s_9 2013 01 DE-16-250 04 p (DE-627)1742696414 Figl, Adina 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1497906962 Scherer, Dominique 2013 01 DE-16-250 05 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1462354653 Lorenzo Bermejo, Justo 2013 01 DE-16-250 06 k (DE-627)1416741593 Institut für Medizinische Biometrie und Informatik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 2013 01 DE-16-250 07 p (DE-627)1747463884 Gast, Andreas 2013 01 DE-16-250 07 k (DE-627)1416535500 Fakultät für Biowissenschaften 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_6 2013 01 DE-16-250 08 p (DE-627)1578469856 Kumar, Rajiv 2013 01 DE-16-250 08 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_11 |
| allfieldsGer |
10.1016/j.mrgentox.2010.06.011 doi (DE-627)1871820847 (DE-599)KXP1871820847 (OCoLC)1425872960 DE-627 ger DE-627 rda eng Figl, Adina 1975- verfasserin (DE-588)1146398816 (DE-627)1005834245 (DE-576)186024819 aut Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma Adina Figl, Dominique Scherer, Eduardo Nagore, Justo Lorenzo Bermejo, Rafael Botella-Estrada, Andreas Gast, Ranjit K. Thirumaran, Dolores Planelles, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar 26 June 2010 9 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 04.12.2023 Single-nucleotide polymorphisms in different DNA-repair genes are reported to modulate risk of various cancers including melanoma. We genotyped DNA from 1186 melanoma patients and 1280 healthy controls for 13 different polymorphisms in eight DNA-repair genes. Data analyses showed that none of the polymorphisms except T241M XRCC3 was associated with an increased risk for cutaneous melanoma. Carriers of the variant alleles were associated with a decreased risk (OR 0.83; 95% CI, 0.79-0.98). Three additional polymorphisms together with T241M XRCC3 that tagged the entire gene region and the neighbouring genes KLC1, ZFYVE21 and PPP1R13B were not associated with the disease risk; neither were the inferred haplotypes. Imputation showed association of comparable magnitude with 11 non-genotyped neighbouring polymorphisms. Finally, the combination of results for all polymorphisms genotyped in the present study with published data suggests that none of the investigated polymorphisms was associated with melanoma susceptibility. We conclude that 13 non-synonymous polymorphisms in eight DNA-repair genes that are frequently investigated with respect to modulation of cancer risk in populations are not associated with susceptibility to cutaneous melanoma. DNA Repair DNA-Binding Proteins Female Humans Kinesins Male Melanoma Polymorphism, Single Nucleotide Skin Neoplasms Scherer, Dominique 1978- verfasserin (DE-588)140126090 (DE-627)616036647 (DE-576)314697233 aut Nagore, Eduardo verfasserin (DE-588)1256183237 (DE-627)1800355742 aut Lorenzo Bermejo, Justo 1972- verfasserin (DE-588)124754619 (DE-627)706705572 (DE-576)294483632 aut Botella-Estrada, Rafael verfasserin aut Gast, Andreas verfasserin (DE-588)1226448496 (DE-627)1747463841 aut Thirumaran, Ranjit Kumar 1978- verfasserin (DE-588)132214466 (DE-627)519239571 (DE-576)299010074 aut Planelles, Dolores verfasserin aut Hemminki, Kari 1947- verfasserin (DE-588)1150735872 (DE-627)1010964402 (DE-576)172043751 aut Schadendorf, Dirk 1960- verfasserin (DE-588)11142576X (DE-627)499566076 (DE-576)289702275 aut Kumar, Rajiv 1955- verfasserin (DE-588)1164253425 (DE-627)1028811942 (DE-576)508469805 aut Enthalten in Mutation research. Genetic toxicology and environmental mutagenesis Amsterdam [u.a.] : Elsevier Science, 1997 702(2010), 1 vom: Sept., Seite 8-16 Online-Ressource (DE-627)503327336 (DE-600)2210272-3 (DE-576)25588480X 1388-2120 nnns volume:702 year:2010 number:1 month:09 pages:8-16 extent:9 https://doi.org/10.1016/j.mrgentox.2010.06.011 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S1383571810002226?via%3Dihub Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 702 2010 1 9 8-16 9 2013 01 DE-16-250 4425003594 00 --%%-- --%%-- --%%-- --%%-- l01 04-12-23 2013 01 DE-16-250 00 s hd2010 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_11 2013 01 DE-16-250 03 s s_9 2013 01 DE-16-250 04 p (DE-627)1742696414 Figl, Adina 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1497906962 Scherer, Dominique 2013 01 DE-16-250 05 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1462354653 Lorenzo Bermejo, Justo 2013 01 DE-16-250 06 k (DE-627)1416741593 Institut für Medizinische Biometrie und Informatik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 2013 01 DE-16-250 07 p (DE-627)1747463884 Gast, Andreas 2013 01 DE-16-250 07 k (DE-627)1416535500 Fakultät für Biowissenschaften 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_6 2013 01 DE-16-250 08 p (DE-627)1578469856 Kumar, Rajiv 2013 01 DE-16-250 08 k (DE-627)1416466967 Medizinische Fakultät Heidelberg 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_11 |
| allfieldsSound |
10.1016/j.mrgentox.2010.06.011 doi (DE-627)1871820847 (DE-599)KXP1871820847 (OCoLC)1425872960 DE-627 ger DE-627 rda eng Figl, Adina 1975- verfasserin (DE-588)1146398816 (DE-627)1005834245 (DE-576)186024819 aut Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma Adina Figl, Dominique Scherer, Eduardo Nagore, Justo Lorenzo Bermejo, Rafael Botella-Estrada, Andreas Gast, Ranjit K. Thirumaran, Dolores Planelles, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar 26 June 2010 9 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 04.12.2023 Single-nucleotide polymorphisms in different DNA-repair genes are reported to modulate risk of various cancers including melanoma. We genotyped DNA from 1186 melanoma patients and 1280 healthy controls for 13 different polymorphisms in eight DNA-repair genes. Data analyses showed that none of the polymorphisms except T241M XRCC3 was associated with an increased risk for cutaneous melanoma. Carriers of the variant alleles were associated with a decreased risk (OR 0.83; 95% CI, 0.79-0.98). Three additional polymorphisms together with T241M XRCC3 that tagged the entire gene region and the neighbouring genes KLC1, ZFYVE21 and PPP1R13B were not associated with the disease risk; neither were the inferred haplotypes. Imputation showed association of comparable magnitude with 11 non-genotyped neighbouring polymorphisms. Finally, the combination of results for all polymorphisms genotyped in the present study with published data suggests that none of the investigated polymorphisms was associated with melanoma susceptibility. We conclude that 13 non-synonymous polymorphisms in eight DNA-repair genes that are frequently investigated with respect to modulation of cancer risk in populations are not associated with susceptibility to cutaneous melanoma. DNA Repair DNA-Binding Proteins Female Humans Kinesins Male Melanoma Polymorphism, Single Nucleotide Skin Neoplasms Scherer, Dominique 1978- verfasserin (DE-588)140126090 (DE-627)616036647 (DE-576)314697233 aut Nagore, Eduardo verfasserin (DE-588)1256183237 (DE-627)1800355742 aut Lorenzo Bermejo, Justo 1972- verfasserin (DE-588)124754619 (DE-627)706705572 (DE-576)294483632 aut Botella-Estrada, Rafael verfasserin aut Gast, Andreas verfasserin (DE-588)1226448496 (DE-627)1747463841 aut Thirumaran, Ranjit Kumar 1978- verfasserin (DE-588)132214466 (DE-627)519239571 (DE-576)299010074 aut Planelles, Dolores verfasserin aut Hemminki, Kari 1947- verfasserin (DE-588)1150735872 (DE-627)1010964402 (DE-576)172043751 aut Schadendorf, Dirk 1960- verfasserin (DE-588)11142576X (DE-627)499566076 (DE-576)289702275 aut Kumar, Rajiv 1955- verfasserin (DE-588)1164253425 (DE-627)1028811942 (DE-576)508469805 aut Enthalten in Mutation research. 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Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma Adina Figl, Dominique Scherer, Eduardo Nagore, Justo Lorenzo Bermejo, Rafael Botella-Estrada, Andreas Gast, Ranjit K. Thirumaran, Dolores Planelles, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar |
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Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma |
| abstract |
Single-nucleotide polymorphisms in different DNA-repair genes are reported to modulate risk of various cancers including melanoma. We genotyped DNA from 1186 melanoma patients and 1280 healthy controls for 13 different polymorphisms in eight DNA-repair genes. Data analyses showed that none of the polymorphisms except T241M XRCC3 was associated with an increased risk for cutaneous melanoma. Carriers of the variant alleles were associated with a decreased risk (OR 0.83; 95% CI, 0.79-0.98). Three additional polymorphisms together with T241M XRCC3 that tagged the entire gene region and the neighbouring genes KLC1, ZFYVE21 and PPP1R13B were not associated with the disease risk; neither were the inferred haplotypes. Imputation showed association of comparable magnitude with 11 non-genotyped neighbouring polymorphisms. Finally, the combination of results for all polymorphisms genotyped in the present study with published data suggests that none of the investigated polymorphisms was associated with melanoma susceptibility. We conclude that 13 non-synonymous polymorphisms in eight DNA-repair genes that are frequently investigated with respect to modulation of cancer risk in populations are not associated with susceptibility to cutaneous melanoma. Gesehen am 04.12.2023 |
| abstractGer |
Single-nucleotide polymorphisms in different DNA-repair genes are reported to modulate risk of various cancers including melanoma. We genotyped DNA from 1186 melanoma patients and 1280 healthy controls for 13 different polymorphisms in eight DNA-repair genes. Data analyses showed that none of the polymorphisms except T241M XRCC3 was associated with an increased risk for cutaneous melanoma. Carriers of the variant alleles were associated with a decreased risk (OR 0.83; 95% CI, 0.79-0.98). Three additional polymorphisms together with T241M XRCC3 that tagged the entire gene region and the neighbouring genes KLC1, ZFYVE21 and PPP1R13B were not associated with the disease risk; neither were the inferred haplotypes. Imputation showed association of comparable magnitude with 11 non-genotyped neighbouring polymorphisms. Finally, the combination of results for all polymorphisms genotyped in the present study with published data suggests that none of the investigated polymorphisms was associated with melanoma susceptibility. We conclude that 13 non-synonymous polymorphisms in eight DNA-repair genes that are frequently investigated with respect to modulation of cancer risk in populations are not associated with susceptibility to cutaneous melanoma. Gesehen am 04.12.2023 |
| abstract_unstemmed |
Single-nucleotide polymorphisms in different DNA-repair genes are reported to modulate risk of various cancers including melanoma. We genotyped DNA from 1186 melanoma patients and 1280 healthy controls for 13 different polymorphisms in eight DNA-repair genes. Data analyses showed that none of the polymorphisms except T241M XRCC3 was associated with an increased risk for cutaneous melanoma. Carriers of the variant alleles were associated with a decreased risk (OR 0.83; 95% CI, 0.79-0.98). Three additional polymorphisms together with T241M XRCC3 that tagged the entire gene region and the neighbouring genes KLC1, ZFYVE21 and PPP1R13B were not associated with the disease risk; neither were the inferred haplotypes. Imputation showed association of comparable magnitude with 11 non-genotyped neighbouring polymorphisms. Finally, the combination of results for all polymorphisms genotyped in the present study with published data suggests that none of the investigated polymorphisms was associated with melanoma susceptibility. We conclude that 13 non-synonymous polymorphisms in eight DNA-repair genes that are frequently investigated with respect to modulation of cancer risk in populations are not associated with susceptibility to cutaneous melanoma. Gesehen am 04.12.2023 |
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| title_short |
Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma |
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https://doi.org/10.1016/j.mrgentox.2010.06.011 https://www.sciencedirect.com/science/article/pii/S1383571810002226?via%3Dihub |
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