Prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction
Background - The aging population has led to a significant increase in heart failure (HF) patients. Related to demographic changes, the burden with comorbidities was shown to increase in patients with HF. Whereas chronic obstructive pulmonary disease (COPD) was yet demonstrated to be associated with...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lau, Felix - 1991- [verfasserIn] Schupp, Tobias - 1995- [verfasserIn] Schmitt, Alexander [verfasserIn] Reinhardt, Marielen [verfasserIn] Abel, Noah [verfasserIn] Abumayyaleh, Mohammad S. A. - 1990- [verfasserIn] Weidner, Kathrin - 1985- [verfasserIn] Dürschmied, Daniel - 1976- [verfasserIn] Ayoub, Mohamed [verfasserIn] Mashayekhi, Kambis [verfasserIn] Akin, Muharrem [verfasserIn] Ayasse, Niklas [verfasserIn] Akın, Ibrahim - 1978- [verfasserIn] Behnes, Michael - 1982- [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
March 2024 |
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| Schlagwörter: |
Chronic obstructive pulmonary disease |
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| Anmerkung: |
Online verfügbar: 23. Januar 2024, Artikelversion: 1. Februar 2024 Gesehen am 25.07.2024 |
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| Umfang: |
Illustrationen 10 |
| Übergeordnetes Werk: |
Enthalten in: Respiratory medicine - Burlington, Mass. : Harcourt, 1999, 223(2024) vom: Apr., Artikel-ID 107536, Seite 1-10 |
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| Übergeordnetes Werk: |
volume:223 ; year:2024 ; month:04 ; elocationid:107536 ; pages:1-10 ; extent:10 |
| Links: |
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| DOI / URN: |
10.1016/j.rmed.2024.107536 |
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| Katalog-ID: |
1896405924 |
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| 245 | 1 | 0 | |a Prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction |c Felix Lau, Tobias Schupp, Alexander Schmitt, Marielen Reinhardt, Noah Abel, Mohammad Abumayyaleh, Kathrin Weidner, Daniel Duerschmied, Mohamed Ayoub, Kambis Mashayekhi, Muharrem Akin, Niklas Ayasse, Ibrahim Akin, Michael Behnes |
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| 520 | |a Background - The aging population has led to a significant increase in heart failure (HF) patients. Related to demographic changes, the burden with comorbidities was shown to increase in patients with HF. Whereas chronic obstructive pulmonary disease (COPD) was yet demonstrated to be associated with adverse outcomes in patients with HF, the prognostic impact of COPD in HF with mildly reduced ejection fraction (HFmrEF) has not yet been clarified. - Objective - The study investigates the prognostic impact of COPD in patients hospitalized with HFmrEF. - Methods - Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022. Patients with COPD were compared to patients without with regard to the primary endpoint all-cause mortality at 30 months (median follow-up). Secondary endpoints comprised in-hospital mortality, HF-related re-hospitalization, cardiac re-hospitalization and major adverse cardiac and cerebrovascular events (MACCE) at 30 months. - Results - A total of 2184 patients with HFmrEF were included with a prevalence of COPD of 12.0 %. Patients with COPD were older (median 77 vs. 75 years; p = 0.025), had increased burden of cardiovascular comorbidities and more advanced HF symptoms. At 30 months, patients with COPD had an increased risk of all-cause mortality compared to patients without (45 % vs. 30 %; HR = 1.667; 95 % CI 1.366-2.034; p = 0.001), alongside with a higher risk of re-hospitalization for worsening HF (20 % vs. 12 %; HR = 1.658; 95 % CI 1.218-2.257; p = 0.001). - Conclusion - COPD is independently associated with adverse outcomes in patients hospitalized with HFmrEF. | ||
| 650 | 4 | |a Chronic obstructive pulmonary disease | |
| 650 | 4 | |a COPD | |
| 650 | 4 | |a Heart failure with mildly reduced ejection fraction | |
| 650 | 4 | |a HFmrEF | |
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10.1016/j.rmed.2024.107536 doi (DE-627)1896405924 (DE-599)KXP1896405924 DE-627 ger DE-627 rda eng Lau, Felix 1991- verfasserin (DE-588)132267129X (DE-627)1882666445 aut Prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction Felix Lau, Tobias Schupp, Alexander Schmitt, Marielen Reinhardt, Noah Abel, Mohammad Abumayyaleh, Kathrin Weidner, Daniel Duerschmied, Mohamed Ayoub, Kambis Mashayekhi, Muharrem Akin, Niklas Ayasse, Ibrahim Akin, Michael Behnes March 2024 Illustrationen 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Online verfügbar: 23. Januar 2024, Artikelversion: 1. Februar 2024 Gesehen am 25.07.2024 Background - The aging population has led to a significant increase in heart failure (HF) patients. Related to demographic changes, the burden with comorbidities was shown to increase in patients with HF. Whereas chronic obstructive pulmonary disease (COPD) was yet demonstrated to be associated with adverse outcomes in patients with HF, the prognostic impact of COPD in HF with mildly reduced ejection fraction (HFmrEF) has not yet been clarified. - Objective - The study investigates the prognostic impact of COPD in patients hospitalized with HFmrEF. - Methods - Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022. Patients with COPD were compared to patients without with regard to the primary endpoint all-cause mortality at 30 months (median follow-up). Secondary endpoints comprised in-hospital mortality, HF-related re-hospitalization, cardiac re-hospitalization and major adverse cardiac and cerebrovascular events (MACCE) at 30 months. - Results - A total of 2184 patients with HFmrEF were included with a prevalence of COPD of 12.0 %. Patients with COPD were older (median 77 vs. 75 years; p = 0.025), had increased burden of cardiovascular comorbidities and more advanced HF symptoms. At 30 months, patients with COPD had an increased risk of all-cause mortality compared to patients without (45 % vs. 30 %; HR = 1.667; 95 % CI 1.366-2.034; p = 0.001), alongside with a higher risk of re-hospitalization for worsening HF (20 % vs. 12 %; HR = 1.658; 95 % CI 1.218-2.257; p = 0.001). - Conclusion - COPD is independently associated with adverse outcomes in patients hospitalized with HFmrEF. Chronic obstructive pulmonary disease COPD Heart failure with mildly reduced ejection fraction HFmrEF Schupp, Tobias 1995- verfasserin (DE-588)1168611091 (DE-627)103237862X (DE-576)51163840X aut Schmitt, Alexander verfasserin aut Reinhardt, Marielen verfasserin aut Abel, Noah verfasserin aut Abumayyaleh, Mohammad S. A. 1990- verfasserin (DE-588)1215107617 (DE-627)172611743X aut Weidner, Kathrin 1985- verfasserin (DE-588)1156687470 (DE-627)1019523891 (DE-576)502375027 aut Dürschmied, Daniel 1976- verfasserin (DE-588)129152196 (DE-627)390022462 (DE-576)187844623 aut Ayoub, Mohamed verfasserin aut Mashayekhi, Kambis verfasserin aut Akin, Muharrem verfasserin aut Ayasse, Niklas verfasserin (DE-588)1204392692 (DE-627)1689715464 aut Akın, Ibrahim 1978- verfasserin (DE-588)132322293 (DE-627)521039010 (DE-576)299074366 aut Behnes, Michael 1982- verfasserin (DE-588)138373361 (DE-627)696560518 (DE-576)307333949 aut Enthalten in Respiratory medicine Burlington, Mass. : Harcourt, 1999 223(2024) vom: Apr., Artikel-ID 107536, Seite 1-10 Online-Ressource (DE-627)320420973 (DE-600)2002557-9 (DE-576)103746870 1532-3064 nnns volume:223 year:2024 month:04 elocationid:107536 pages:1-10 extent:10 https://doi.org/10.1016/j.rmed.2024.107536 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0954611124000106 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 223 2024 4 107536 1-10 10 2013 01 DE-16-250 4556994438 00 --%%-- --%%-- --%%-- --%%-- l01 25-07-24 2013 01 DE-16-250 00 s hd2024 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_14 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1882666518 Lau, Felix 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1587770318 Schupp, Tobias 2013 01 DE-16-250 05 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1765319951 Abumayyaleh, Mohammad S. A. 2013 01 DE-16-250 06 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_6 2013 01 DE-16-250 07 p (DE-627)1572375531 Weidner, Kathrin 2013 01 DE-16-250 07 k (DE-627)1416822720 Extern 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_7 2013 01 DE-16-250 08 p (DE-627)1830842358 Dürschmied, Daniel 2013 01 DE-16-250 08 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_8 2013 01 DE-16-250 09 p (DE-627)1689855002 Ayasse, Niklas 2013 01 DE-16-250 09 k (DE-627)1416822720 Extern 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_12 2013 01 DE-16-250 10 p (DE-627)1504248562 Akın, Ibrahim 2013 01 DE-16-250 10 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 10 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 10 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 10 s pos_13 2013 01 DE-16-250 11 p (DE-627)1441366393 Behnes, Michael 2013 01 DE-16-250 11 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 11 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 11 s pos_14 |
| spelling |
10.1016/j.rmed.2024.107536 doi (DE-627)1896405924 (DE-599)KXP1896405924 DE-627 ger DE-627 rda eng Lau, Felix 1991- verfasserin (DE-588)132267129X (DE-627)1882666445 aut Prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction Felix Lau, Tobias Schupp, Alexander Schmitt, Marielen Reinhardt, Noah Abel, Mohammad Abumayyaleh, Kathrin Weidner, Daniel Duerschmied, Mohamed Ayoub, Kambis Mashayekhi, Muharrem Akin, Niklas Ayasse, Ibrahim Akin, Michael Behnes March 2024 Illustrationen 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Online verfügbar: 23. Januar 2024, Artikelversion: 1. Februar 2024 Gesehen am 25.07.2024 Background - The aging population has led to a significant increase in heart failure (HF) patients. Related to demographic changes, the burden with comorbidities was shown to increase in patients with HF. Whereas chronic obstructive pulmonary disease (COPD) was yet demonstrated to be associated with adverse outcomes in patients with HF, the prognostic impact of COPD in HF with mildly reduced ejection fraction (HFmrEF) has not yet been clarified. - Objective - The study investigates the prognostic impact of COPD in patients hospitalized with HFmrEF. - Methods - Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022. Patients with COPD were compared to patients without with regard to the primary endpoint all-cause mortality at 30 months (median follow-up). Secondary endpoints comprised in-hospital mortality, HF-related re-hospitalization, cardiac re-hospitalization and major adverse cardiac and cerebrovascular events (MACCE) at 30 months. - Results - A total of 2184 patients with HFmrEF were included with a prevalence of COPD of 12.0 %. Patients with COPD were older (median 77 vs. 75 years; p = 0.025), had increased burden of cardiovascular comorbidities and more advanced HF symptoms. At 30 months, patients with COPD had an increased risk of all-cause mortality compared to patients without (45 % vs. 30 %; HR = 1.667; 95 % CI 1.366-2.034; p = 0.001), alongside with a higher risk of re-hospitalization for worsening HF (20 % vs. 12 %; HR = 1.658; 95 % CI 1.218-2.257; p = 0.001). - Conclusion - COPD is independently associated with adverse outcomes in patients hospitalized with HFmrEF. Chronic obstructive pulmonary disease COPD Heart failure with mildly reduced ejection fraction HFmrEF Schupp, Tobias 1995- verfasserin (DE-588)1168611091 (DE-627)103237862X (DE-576)51163840X aut Schmitt, Alexander verfasserin aut Reinhardt, Marielen verfasserin aut Abel, Noah verfasserin aut Abumayyaleh, Mohammad S. A. 1990- verfasserin (DE-588)1215107617 (DE-627)172611743X aut Weidner, Kathrin 1985- verfasserin (DE-588)1156687470 (DE-627)1019523891 (DE-576)502375027 aut Dürschmied, Daniel 1976- verfasserin (DE-588)129152196 (DE-627)390022462 (DE-576)187844623 aut Ayoub, Mohamed verfasserin aut Mashayekhi, Kambis verfasserin aut Akin, Muharrem verfasserin aut Ayasse, Niklas verfasserin (DE-588)1204392692 (DE-627)1689715464 aut Akın, Ibrahim 1978- verfasserin (DE-588)132322293 (DE-627)521039010 (DE-576)299074366 aut Behnes, Michael 1982- verfasserin (DE-588)138373361 (DE-627)696560518 (DE-576)307333949 aut Enthalten in Respiratory medicine Burlington, Mass. : Harcourt, 1999 223(2024) vom: Apr., Artikel-ID 107536, Seite 1-10 Online-Ressource (DE-627)320420973 (DE-600)2002557-9 (DE-576)103746870 1532-3064 nnns volume:223 year:2024 month:04 elocationid:107536 pages:1-10 extent:10 https://doi.org/10.1016/j.rmed.2024.107536 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0954611124000106 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 223 2024 4 107536 1-10 10 2013 01 DE-16-250 4556994438 00 --%%-- --%%-- --%%-- --%%-- l01 25-07-24 2013 01 DE-16-250 00 s hd2024 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_14 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1882666518 Lau, Felix 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1587770318 Schupp, Tobias 2013 01 DE-16-250 05 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1765319951 Abumayyaleh, Mohammad S. A. 2013 01 DE-16-250 06 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_6 2013 01 DE-16-250 07 p (DE-627)1572375531 Weidner, Kathrin 2013 01 DE-16-250 07 k (DE-627)1416822720 Extern 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_7 2013 01 DE-16-250 08 p (DE-627)1830842358 Dürschmied, Daniel 2013 01 DE-16-250 08 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_8 2013 01 DE-16-250 09 p (DE-627)1689855002 Ayasse, Niklas 2013 01 DE-16-250 09 k (DE-627)1416822720 Extern 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_12 2013 01 DE-16-250 10 p (DE-627)1504248562 Akın, Ibrahim 2013 01 DE-16-250 10 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 10 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 10 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 10 s pos_13 2013 01 DE-16-250 11 p (DE-627)1441366393 Behnes, Michael 2013 01 DE-16-250 11 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 11 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 11 s pos_14 |
| allfields_unstemmed |
10.1016/j.rmed.2024.107536 doi (DE-627)1896405924 (DE-599)KXP1896405924 DE-627 ger DE-627 rda eng Lau, Felix 1991- verfasserin (DE-588)132267129X (DE-627)1882666445 aut Prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction Felix Lau, Tobias Schupp, Alexander Schmitt, Marielen Reinhardt, Noah Abel, Mohammad Abumayyaleh, Kathrin Weidner, Daniel Duerschmied, Mohamed Ayoub, Kambis Mashayekhi, Muharrem Akin, Niklas Ayasse, Ibrahim Akin, Michael Behnes March 2024 Illustrationen 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Online verfügbar: 23. Januar 2024, Artikelversion: 1. Februar 2024 Gesehen am 25.07.2024 Background - The aging population has led to a significant increase in heart failure (HF) patients. Related to demographic changes, the burden with comorbidities was shown to increase in patients with HF. Whereas chronic obstructive pulmonary disease (COPD) was yet demonstrated to be associated with adverse outcomes in patients with HF, the prognostic impact of COPD in HF with mildly reduced ejection fraction (HFmrEF) has not yet been clarified. - Objective - The study investigates the prognostic impact of COPD in patients hospitalized with HFmrEF. - Methods - Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022. Patients with COPD were compared to patients without with regard to the primary endpoint all-cause mortality at 30 months (median follow-up). Secondary endpoints comprised in-hospital mortality, HF-related re-hospitalization, cardiac re-hospitalization and major adverse cardiac and cerebrovascular events (MACCE) at 30 months. - Results - A total of 2184 patients with HFmrEF were included with a prevalence of COPD of 12.0 %. Patients with COPD were older (median 77 vs. 75 years; p = 0.025), had increased burden of cardiovascular comorbidities and more advanced HF symptoms. At 30 months, patients with COPD had an increased risk of all-cause mortality compared to patients without (45 % vs. 30 %; HR = 1.667; 95 % CI 1.366-2.034; p = 0.001), alongside with a higher risk of re-hospitalization for worsening HF (20 % vs. 12 %; HR = 1.658; 95 % CI 1.218-2.257; p = 0.001). - Conclusion - COPD is independently associated with adverse outcomes in patients hospitalized with HFmrEF. Chronic obstructive pulmonary disease COPD Heart failure with mildly reduced ejection fraction HFmrEF Schupp, Tobias 1995- verfasserin (DE-588)1168611091 (DE-627)103237862X (DE-576)51163840X aut Schmitt, Alexander verfasserin aut Reinhardt, Marielen verfasserin aut Abel, Noah verfasserin aut Abumayyaleh, Mohammad S. A. 1990- verfasserin (DE-588)1215107617 (DE-627)172611743X aut Weidner, Kathrin 1985- verfasserin (DE-588)1156687470 (DE-627)1019523891 (DE-576)502375027 aut Dürschmied, Daniel 1976- verfasserin (DE-588)129152196 (DE-627)390022462 (DE-576)187844623 aut Ayoub, Mohamed verfasserin aut Mashayekhi, Kambis verfasserin aut Akin, Muharrem verfasserin aut Ayasse, Niklas verfasserin (DE-588)1204392692 (DE-627)1689715464 aut Akın, Ibrahim 1978- verfasserin (DE-588)132322293 (DE-627)521039010 (DE-576)299074366 aut Behnes, Michael 1982- verfasserin (DE-588)138373361 (DE-627)696560518 (DE-576)307333949 aut Enthalten in Respiratory medicine Burlington, Mass. : Harcourt, 1999 223(2024) vom: Apr., Artikel-ID 107536, Seite 1-10 Online-Ressource (DE-627)320420973 (DE-600)2002557-9 (DE-576)103746870 1532-3064 nnns volume:223 year:2024 month:04 elocationid:107536 pages:1-10 extent:10 https://doi.org/10.1016/j.rmed.2024.107536 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0954611124000106 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 223 2024 4 107536 1-10 10 2013 01 DE-16-250 4556994438 00 --%%-- --%%-- --%%-- --%%-- l01 25-07-24 2013 01 DE-16-250 00 s hd2024 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_14 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1882666518 Lau, Felix 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1587770318 Schupp, Tobias 2013 01 DE-16-250 05 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1765319951 Abumayyaleh, Mohammad S. A. 2013 01 DE-16-250 06 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_6 2013 01 DE-16-250 07 p (DE-627)1572375531 Weidner, Kathrin 2013 01 DE-16-250 07 k (DE-627)1416822720 Extern 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_7 2013 01 DE-16-250 08 p (DE-627)1830842358 Dürschmied, Daniel 2013 01 DE-16-250 08 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_8 2013 01 DE-16-250 09 p (DE-627)1689855002 Ayasse, Niklas 2013 01 DE-16-250 09 k (DE-627)1416822720 Extern 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_12 2013 01 DE-16-250 10 p (DE-627)1504248562 Akın, Ibrahim 2013 01 DE-16-250 10 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 10 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 10 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 10 s pos_13 2013 01 DE-16-250 11 p (DE-627)1441366393 Behnes, Michael 2013 01 DE-16-250 11 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 11 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 11 s pos_14 |
| allfieldsGer |
10.1016/j.rmed.2024.107536 doi (DE-627)1896405924 (DE-599)KXP1896405924 DE-627 ger DE-627 rda eng Lau, Felix 1991- verfasserin (DE-588)132267129X (DE-627)1882666445 aut Prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction Felix Lau, Tobias Schupp, Alexander Schmitt, Marielen Reinhardt, Noah Abel, Mohammad Abumayyaleh, Kathrin Weidner, Daniel Duerschmied, Mohamed Ayoub, Kambis Mashayekhi, Muharrem Akin, Niklas Ayasse, Ibrahim Akin, Michael Behnes March 2024 Illustrationen 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Online verfügbar: 23. Januar 2024, Artikelversion: 1. Februar 2024 Gesehen am 25.07.2024 Background - The aging population has led to a significant increase in heart failure (HF) patients. Related to demographic changes, the burden with comorbidities was shown to increase in patients with HF. Whereas chronic obstructive pulmonary disease (COPD) was yet demonstrated to be associated with adverse outcomes in patients with HF, the prognostic impact of COPD in HF with mildly reduced ejection fraction (HFmrEF) has not yet been clarified. - Objective - The study investigates the prognostic impact of COPD in patients hospitalized with HFmrEF. - Methods - Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022. Patients with COPD were compared to patients without with regard to the primary endpoint all-cause mortality at 30 months (median follow-up). Secondary endpoints comprised in-hospital mortality, HF-related re-hospitalization, cardiac re-hospitalization and major adverse cardiac and cerebrovascular events (MACCE) at 30 months. - Results - A total of 2184 patients with HFmrEF were included with a prevalence of COPD of 12.0 %. Patients with COPD were older (median 77 vs. 75 years; p = 0.025), had increased burden of cardiovascular comorbidities and more advanced HF symptoms. At 30 months, patients with COPD had an increased risk of all-cause mortality compared to patients without (45 % vs. 30 %; HR = 1.667; 95 % CI 1.366-2.034; p = 0.001), alongside with a higher risk of re-hospitalization for worsening HF (20 % vs. 12 %; HR = 1.658; 95 % CI 1.218-2.257; p = 0.001). - Conclusion - COPD is independently associated with adverse outcomes in patients hospitalized with HFmrEF. Chronic obstructive pulmonary disease COPD Heart failure with mildly reduced ejection fraction HFmrEF Schupp, Tobias 1995- verfasserin (DE-588)1168611091 (DE-627)103237862X (DE-576)51163840X aut Schmitt, Alexander verfasserin aut Reinhardt, Marielen verfasserin aut Abel, Noah verfasserin aut Abumayyaleh, Mohammad S. A. 1990- verfasserin (DE-588)1215107617 (DE-627)172611743X aut Weidner, Kathrin 1985- verfasserin (DE-588)1156687470 (DE-627)1019523891 (DE-576)502375027 aut Dürschmied, Daniel 1976- verfasserin (DE-588)129152196 (DE-627)390022462 (DE-576)187844623 aut Ayoub, Mohamed verfasserin aut Mashayekhi, Kambis verfasserin aut Akin, Muharrem verfasserin aut Ayasse, Niklas verfasserin (DE-588)1204392692 (DE-627)1689715464 aut Akın, Ibrahim 1978- verfasserin (DE-588)132322293 (DE-627)521039010 (DE-576)299074366 aut Behnes, Michael 1982- verfasserin (DE-588)138373361 (DE-627)696560518 (DE-576)307333949 aut Enthalten in Respiratory medicine Burlington, Mass. : Harcourt, 1999 223(2024) vom: Apr., Artikel-ID 107536, Seite 1-10 Online-Ressource (DE-627)320420973 (DE-600)2002557-9 (DE-576)103746870 1532-3064 nnns volume:223 year:2024 month:04 elocationid:107536 pages:1-10 extent:10 https://doi.org/10.1016/j.rmed.2024.107536 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0954611124000106 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 223 2024 4 107536 1-10 10 2013 01 DE-16-250 4556994438 00 --%%-- --%%-- --%%-- --%%-- l01 25-07-24 2013 01 DE-16-250 00 s hd2024 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_14 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1882666518 Lau, Felix 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1587770318 Schupp, Tobias 2013 01 DE-16-250 05 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1765319951 Abumayyaleh, Mohammad S. A. 2013 01 DE-16-250 06 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_6 2013 01 DE-16-250 07 p (DE-627)1572375531 Weidner, Kathrin 2013 01 DE-16-250 07 k (DE-627)1416822720 Extern 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_7 2013 01 DE-16-250 08 p (DE-627)1830842358 Dürschmied, Daniel 2013 01 DE-16-250 08 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_8 2013 01 DE-16-250 09 p (DE-627)1689855002 Ayasse, Niklas 2013 01 DE-16-250 09 k (DE-627)1416822720 Extern 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_12 2013 01 DE-16-250 10 p (DE-627)1504248562 Akın, Ibrahim 2013 01 DE-16-250 10 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 10 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 10 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 10 s pos_13 2013 01 DE-16-250 11 p (DE-627)1441366393 Behnes, Michael 2013 01 DE-16-250 11 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 11 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 11 s pos_14 |
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10.1016/j.rmed.2024.107536 doi (DE-627)1896405924 (DE-599)KXP1896405924 DE-627 ger DE-627 rda eng Lau, Felix 1991- verfasserin (DE-588)132267129X (DE-627)1882666445 aut Prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction Felix Lau, Tobias Schupp, Alexander Schmitt, Marielen Reinhardt, Noah Abel, Mohammad Abumayyaleh, Kathrin Weidner, Daniel Duerschmied, Mohamed Ayoub, Kambis Mashayekhi, Muharrem Akin, Niklas Ayasse, Ibrahim Akin, Michael Behnes March 2024 Illustrationen 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Online verfügbar: 23. Januar 2024, Artikelversion: 1. Februar 2024 Gesehen am 25.07.2024 Background - The aging population has led to a significant increase in heart failure (HF) patients. Related to demographic changes, the burden with comorbidities was shown to increase in patients with HF. Whereas chronic obstructive pulmonary disease (COPD) was yet demonstrated to be associated with adverse outcomes in patients with HF, the prognostic impact of COPD in HF with mildly reduced ejection fraction (HFmrEF) has not yet been clarified. - Objective - The study investigates the prognostic impact of COPD in patients hospitalized with HFmrEF. - Methods - Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022. Patients with COPD were compared to patients without with regard to the primary endpoint all-cause mortality at 30 months (median follow-up). Secondary endpoints comprised in-hospital mortality, HF-related re-hospitalization, cardiac re-hospitalization and major adverse cardiac and cerebrovascular events (MACCE) at 30 months. - Results - A total of 2184 patients with HFmrEF were included with a prevalence of COPD of 12.0 %. Patients with COPD were older (median 77 vs. 75 years; p = 0.025), had increased burden of cardiovascular comorbidities and more advanced HF symptoms. At 30 months, patients with COPD had an increased risk of all-cause mortality compared to patients without (45 % vs. 30 %; HR = 1.667; 95 % CI 1.366-2.034; p = 0.001), alongside with a higher risk of re-hospitalization for worsening HF (20 % vs. 12 %; HR = 1.658; 95 % CI 1.218-2.257; p = 0.001). - Conclusion - COPD is independently associated with adverse outcomes in patients hospitalized with HFmrEF. Chronic obstructive pulmonary disease COPD Heart failure with mildly reduced ejection fraction HFmrEF Schupp, Tobias 1995- verfasserin (DE-588)1168611091 (DE-627)103237862X (DE-576)51163840X aut Schmitt, Alexander verfasserin aut Reinhardt, Marielen verfasserin aut Abel, Noah verfasserin aut Abumayyaleh, Mohammad S. A. 1990- verfasserin (DE-588)1215107617 (DE-627)172611743X aut Weidner, Kathrin 1985- verfasserin (DE-588)1156687470 (DE-627)1019523891 (DE-576)502375027 aut Dürschmied, Daniel 1976- verfasserin (DE-588)129152196 (DE-627)390022462 (DE-576)187844623 aut Ayoub, Mohamed verfasserin aut Mashayekhi, Kambis verfasserin aut Akin, Muharrem verfasserin aut Ayasse, Niklas verfasserin (DE-588)1204392692 (DE-627)1689715464 aut Akın, Ibrahim 1978- verfasserin (DE-588)132322293 (DE-627)521039010 (DE-576)299074366 aut Behnes, Michael 1982- verfasserin (DE-588)138373361 (DE-627)696560518 (DE-576)307333949 aut Enthalten in Respiratory medicine Burlington, Mass. : Harcourt, 1999 223(2024) vom: Apr., Artikel-ID 107536, Seite 1-10 Online-Ressource (DE-627)320420973 (DE-600)2002557-9 (DE-576)103746870 1532-3064 nnns volume:223 year:2024 month:04 elocationid:107536 pages:1-10 extent:10 https://doi.org/10.1016/j.rmed.2024.107536 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0954611124000106 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 223 2024 4 107536 1-10 10 2013 01 DE-16-250 4556994438 00 --%%-- --%%-- --%%-- --%%-- l01 25-07-24 2013 01 DE-16-250 00 s hd2024 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_14 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1882666518 Lau, Felix 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1587770318 Schupp, Tobias 2013 01 DE-16-250 05 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1765319951 Abumayyaleh, Mohammad S. A. 2013 01 DE-16-250 06 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_6 2013 01 DE-16-250 07 p (DE-627)1572375531 Weidner, Kathrin 2013 01 DE-16-250 07 k (DE-627)1416822720 Extern 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_7 2013 01 DE-16-250 08 p (DE-627)1830842358 Dürschmied, Daniel 2013 01 DE-16-250 08 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_8 2013 01 DE-16-250 09 p (DE-627)1689855002 Ayasse, Niklas 2013 01 DE-16-250 09 k (DE-627)1416822720 Extern 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_12 2013 01 DE-16-250 10 p (DE-627)1504248562 Akın, Ibrahim 2013 01 DE-16-250 10 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 10 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 10 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 10 s pos_13 2013 01 DE-16-250 11 p (DE-627)1441366393 Behnes, Michael 2013 01 DE-16-250 11 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 11 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 11 s pos_14 |
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Januar 2024, Artikelversion: 1. Februar 2024</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Gesehen am 25.07.2024</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background - The aging population has led to a significant increase in heart failure (HF) patients. Related to demographic changes, the burden with comorbidities was shown to increase in patients with HF. Whereas chronic obstructive pulmonary disease (COPD) was yet demonstrated to be associated with adverse outcomes in patients with HF, the prognostic impact of COPD in HF with mildly reduced ejection fraction (HFmrEF) has not yet been clarified. - Objective - The study investigates the prognostic impact of COPD in patients hospitalized with HFmrEF. - Methods - Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022. Patients with COPD were compared to patients without with regard to the primary endpoint all-cause mortality at 30 months (median follow-up). Secondary endpoints comprised in-hospital mortality, HF-related re-hospitalization, cardiac re-hospitalization and major adverse cardiac and cerebrovascular events (MACCE) at 30 months. - Results - A total of 2184 patients with HFmrEF were included with a prevalence of COPD of 12.0 %. Patients with COPD were older (median 77 vs. 75 years; p = 0.025), had increased burden of cardiovascular comorbidities and more advanced HF symptoms. At 30 months, patients with COPD had an increased risk of all-cause mortality compared to patients without (45 % vs. 30 %; HR = 1.667; 95 % CI 1.366-2.034; p = 0.001), alongside with a higher risk of re-hospitalization for worsening HF (20 % vs. 12 %; HR = 1.658; 95 % CI 1.218-2.257; p = 0.001). - Conclusion - COPD is independently associated with adverse outcomes in patients hospitalized with HFmrEF.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chronic obstructive pulmonary disease</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">COPD</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Heart failure with mildly reduced ejection fraction</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">HFmrEF</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schupp, Tobias</subfield><subfield code="d">1995-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)1168611091</subfield><subfield code="0">(DE-627)103237862X</subfield><subfield code="0">(DE-576)51163840X</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schmitt, Alexander</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Reinhardt, Marielen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Abel, Noah</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Abumayyaleh, Mohammad S. A.</subfield><subfield code="d">1990-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)1215107617</subfield><subfield code="0">(DE-627)172611743X</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Weidner, Kathrin</subfield><subfield code="d">1985-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)1156687470</subfield><subfield code="0">(DE-627)1019523891</subfield><subfield code="0">(DE-576)502375027</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dürschmied, Daniel</subfield><subfield code="d">1976-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)129152196</subfield><subfield code="0">(DE-627)390022462</subfield><subfield code="0">(DE-576)187844623</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ayoub, Mohamed</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mashayekhi, Kambis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Akin, Muharrem</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ayasse, Niklas</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)1204392692</subfield><subfield code="0">(DE-627)1689715464</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Akın, Ibrahim</subfield><subfield code="d">1978-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)132322293</subfield><subfield code="0">(DE-627)521039010</subfield><subfield code="0">(DE-576)299074366</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Behnes, Michael</subfield><subfield code="d">1982-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)138373361</subfield><subfield code="0">(DE-627)696560518</subfield><subfield code="0">(DE-576)307333949</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Respiratory medicine</subfield><subfield code="d">Burlington, Mass. : Harcourt, 1999</subfield><subfield code="g">223(2024) vom: Apr., Artikel-ID 107536, Seite 1-10</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)320420973</subfield><subfield code="w">(DE-600)2002557-9</subfield><subfield code="w">(DE-576)103746870</subfield><subfield code="x">1532-3064</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" 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2013 01 DE-16-250 00 s hd2024 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_14 2013 01 DE-16-250 03 s s_10 2013 01 DE-16-250 04 p (DE-627)1882666518 Lau, Felix 2013 01 DE-16-250 04 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1587770318 Schupp, Tobias 2013 01 DE-16-250 05 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1765319951 Abumayyaleh, Mohammad S. A. 2013 01 DE-16-250 06 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_6 2013 01 DE-16-250 07 p (DE-627)1572375531 Weidner, Kathrin 2013 01 DE-16-250 07 k (DE-627)1416822720 Extern 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_7 2013 01 DE-16-250 08 p (DE-627)1830842358 Dürschmied, Daniel 2013 01 DE-16-250 08 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_8 2013 01 DE-16-250 09 p (DE-627)1689855002 Ayasse, Niklas 2013 01 DE-16-250 09 k (DE-627)1416822720 Extern 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_12 2013 01 DE-16-250 10 p (DE-627)1504248562 Akın, Ibrahim 2013 01 DE-16-250 10 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 10 k (DE-627)1416467254 Medizinische Fakultät Mannheim 2013 01 DE-16-250 10 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 10 s pos_13 2013 01 DE-16-250 11 p (DE-627)1441366393 Behnes, Michael 2013 01 DE-16-250 11 k (DE-627)1416468366 I. Medizinische Klinik 2013 01 DE-16-250 11 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 11 s pos_14 Prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction Felix Lau, Tobias Schupp, Alexander Schmitt, Marielen Reinhardt, Noah Abel, Mohammad Abumayyaleh, Kathrin Weidner, Daniel Duerschmied, Mohamed Ayoub, Kambis Mashayekhi, Muharrem Akin, Niklas Ayasse, Ibrahim Akin, Michael Behnes Chronic obstructive pulmonary disease COPD Heart failure with mildly reduced ejection fraction HFmrEF |
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Prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction Felix Lau, Tobias Schupp, Alexander Schmitt, Marielen Reinhardt, Noah Abel, Mohammad Abumayyaleh, Kathrin Weidner, Daniel Duerschmied, Mohamed Ayoub, Kambis Mashayekhi, Muharrem Akin, Niklas Ayasse, Ibrahim Akin, Michael Behnes |
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prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction |
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Prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction |
| abstract |
Background - The aging population has led to a significant increase in heart failure (HF) patients. Related to demographic changes, the burden with comorbidities was shown to increase in patients with HF. Whereas chronic obstructive pulmonary disease (COPD) was yet demonstrated to be associated with adverse outcomes in patients with HF, the prognostic impact of COPD in HF with mildly reduced ejection fraction (HFmrEF) has not yet been clarified. - Objective - The study investigates the prognostic impact of COPD in patients hospitalized with HFmrEF. - Methods - Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022. Patients with COPD were compared to patients without with regard to the primary endpoint all-cause mortality at 30 months (median follow-up). Secondary endpoints comprised in-hospital mortality, HF-related re-hospitalization, cardiac re-hospitalization and major adverse cardiac and cerebrovascular events (MACCE) at 30 months. - Results - A total of 2184 patients with HFmrEF were included with a prevalence of COPD of 12.0 %. Patients with COPD were older (median 77 vs. 75 years; p = 0.025), had increased burden of cardiovascular comorbidities and more advanced HF symptoms. At 30 months, patients with COPD had an increased risk of all-cause mortality compared to patients without (45 % vs. 30 %; HR = 1.667; 95 % CI 1.366-2.034; p = 0.001), alongside with a higher risk of re-hospitalization for worsening HF (20 % vs. 12 %; HR = 1.658; 95 % CI 1.218-2.257; p = 0.001). - Conclusion - COPD is independently associated with adverse outcomes in patients hospitalized with HFmrEF. Online verfügbar: 23. Januar 2024, Artikelversion: 1. Februar 2024 Gesehen am 25.07.2024 |
| abstractGer |
Background - The aging population has led to a significant increase in heart failure (HF) patients. Related to demographic changes, the burden with comorbidities was shown to increase in patients with HF. Whereas chronic obstructive pulmonary disease (COPD) was yet demonstrated to be associated with adverse outcomes in patients with HF, the prognostic impact of COPD in HF with mildly reduced ejection fraction (HFmrEF) has not yet been clarified. - Objective - The study investigates the prognostic impact of COPD in patients hospitalized with HFmrEF. - Methods - Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022. Patients with COPD were compared to patients without with regard to the primary endpoint all-cause mortality at 30 months (median follow-up). Secondary endpoints comprised in-hospital mortality, HF-related re-hospitalization, cardiac re-hospitalization and major adverse cardiac and cerebrovascular events (MACCE) at 30 months. - Results - A total of 2184 patients with HFmrEF were included with a prevalence of COPD of 12.0 %. Patients with COPD were older (median 77 vs. 75 years; p = 0.025), had increased burden of cardiovascular comorbidities and more advanced HF symptoms. At 30 months, patients with COPD had an increased risk of all-cause mortality compared to patients without (45 % vs. 30 %; HR = 1.667; 95 % CI 1.366-2.034; p = 0.001), alongside with a higher risk of re-hospitalization for worsening HF (20 % vs. 12 %; HR = 1.658; 95 % CI 1.218-2.257; p = 0.001). - Conclusion - COPD is independently associated with adverse outcomes in patients hospitalized with HFmrEF. Online verfügbar: 23. Januar 2024, Artikelversion: 1. Februar 2024 Gesehen am 25.07.2024 |
| abstract_unstemmed |
Background - The aging population has led to a significant increase in heart failure (HF) patients. Related to demographic changes, the burden with comorbidities was shown to increase in patients with HF. Whereas chronic obstructive pulmonary disease (COPD) was yet demonstrated to be associated with adverse outcomes in patients with HF, the prognostic impact of COPD in HF with mildly reduced ejection fraction (HFmrEF) has not yet been clarified. - Objective - The study investigates the prognostic impact of COPD in patients hospitalized with HFmrEF. - Methods - Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022. Patients with COPD were compared to patients without with regard to the primary endpoint all-cause mortality at 30 months (median follow-up). Secondary endpoints comprised in-hospital mortality, HF-related re-hospitalization, cardiac re-hospitalization and major adverse cardiac and cerebrovascular events (MACCE) at 30 months. - Results - A total of 2184 patients with HFmrEF were included with a prevalence of COPD of 12.0 %. Patients with COPD were older (median 77 vs. 75 years; p = 0.025), had increased burden of cardiovascular comorbidities and more advanced HF symptoms. At 30 months, patients with COPD had an increased risk of all-cause mortality compared to patients without (45 % vs. 30 %; HR = 1.667; 95 % CI 1.366-2.034; p = 0.001), alongside with a higher risk of re-hospitalization for worsening HF (20 % vs. 12 %; HR = 1.658; 95 % CI 1.218-2.257; p = 0.001). - Conclusion - COPD is independently associated with adverse outcomes in patients hospitalized with HFmrEF. Online verfügbar: 23. Januar 2024, Artikelversion: 1. Februar 2024 Gesehen am 25.07.2024 |
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Prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction |
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https://doi.org/10.1016/j.rmed.2024.107536 https://www.sciencedirect.com/science/article/pii/S0954611124000106 |
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Januar 2024, Artikelversion: 1. Februar 2024</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Gesehen am 25.07.2024</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background - The aging population has led to a significant increase in heart failure (HF) patients. Related to demographic changes, the burden with comorbidities was shown to increase in patients with HF. Whereas chronic obstructive pulmonary disease (COPD) was yet demonstrated to be associated with adverse outcomes in patients with HF, the prognostic impact of COPD in HF with mildly reduced ejection fraction (HFmrEF) has not yet been clarified. - Objective - The study investigates the prognostic impact of COPD in patients hospitalized with HFmrEF. - Methods - Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022. Patients with COPD were compared to patients without with regard to the primary endpoint all-cause mortality at 30 months (median follow-up). Secondary endpoints comprised in-hospital mortality, HF-related re-hospitalization, cardiac re-hospitalization and major adverse cardiac and cerebrovascular events (MACCE) at 30 months. - Results - A total of 2184 patients with HFmrEF were included with a prevalence of COPD of 12.0 %. Patients with COPD were older (median 77 vs. 75 years; p = 0.025), had increased burden of cardiovascular comorbidities and more advanced HF symptoms. At 30 months, patients with COPD had an increased risk of all-cause mortality compared to patients without (45 % vs. 30 %; HR = 1.667; 95 % CI 1.366-2.034; p = 0.001), alongside with a higher risk of re-hospitalization for worsening HF (20 % vs. 12 %; HR = 1.658; 95 % CI 1.218-2.257; p = 0.001). - Conclusion - COPD is independently associated with adverse outcomes in patients hospitalized with HFmrEF.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chronic obstructive pulmonary disease</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">COPD</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Heart failure with mildly reduced ejection fraction</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">HFmrEF</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schupp, Tobias</subfield><subfield code="d">1995-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)1168611091</subfield><subfield code="0">(DE-627)103237862X</subfield><subfield code="0">(DE-576)51163840X</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schmitt, Alexander</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Reinhardt, Marielen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Abel, Noah</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Abumayyaleh, Mohammad S. 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