Neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity
Alcohol consumption is a widespread phenomenon throughout the world. However, how recreational alcohol use evolves into alcohol use disorder (AUD) remains poorly understood. The Smpd3 gene and its coded protein neutral sphingomyelinase (NSM) are associated with alcohol consumption in humans and alco...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wank, Isabel - 1985- [verfasserIn] Mittmann, Claire [verfasserIn] Kreitz, Silke [verfasserIn] Chestnykh, Daria [verfasserIn] Mühle, Christiane [verfasserIn] Kornhuber, Johannes [verfasserIn] Ludwig, Andreas [verfasserIn] Kalinichenko, Liubov S. [verfasserIn] Müller, Christian P. [verfasserIn] Hess, Andreas [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
16 April 2024 |
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| Schlagwörter: |
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| Anmerkung: |
Gesehen am 10.09.2024 |
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| Umfang: |
13 |
| Übergeordnetes Werk: |
Enthalten in: Neuropharmacology - Amsterdam [u.a.] : Elsevier Science, 1970, 253(2024), Artikel-ID 109948, Seite 1-13 |
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| Übergeordnetes Werk: |
volume:253 ; year:2024 ; elocationid:109948 ; pages:1-13 ; extent:13 |
| Links: |
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| DOI / URN: |
10.1016/j.neuropharm.2024.109948 |
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190226553X |
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| 245 | 1 | 0 | |a Neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity |c Isabel Wank, Claire Mittmann, Silke Kreitz, Daria Chestnykh, Christiane Mühle, Johannes Kornhuber, Andreas Ludwig, Liubov S. Kalinichenko, Christian P. Müller, Andreas Hess |
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| 520 | |a Alcohol consumption is a widespread phenomenon throughout the world. However, how recreational alcohol use evolves into alcohol use disorder (AUD) remains poorly understood. The Smpd3 gene and its coded protein neutral sphingomyelinase (NSM) are associated with alcohol consumption in humans and alcohol-related behaviors in mice, suggesting a potential role in this transition. Using multiparametric magnetic resonance imaging, we characterized the role of NSM in acute and chronic effects of alcohol on brain anatomy and function in female mice. Chronic voluntary alcohol consumption (16 vol% for at least 6 days) affected brain anatomy in WT mice, reducing regional structure volume predominantly in cortical regions. Attenuated NSM activity prevented these anatomical changes. Functional MRI linked these anatomical adaptations to functional changes: Chronic alcohol consumption in mice significantly modulated resting state functional connectivity (RS FC) in response to an acute ethanol challenge (i.p. bolus of 2 g kg−1) in heterozygous NSM knockout (Fro), but not in WT mice. Acute ethanol administration in alcohol-naïve WT mice significantly decreased RS FC in cortical and brainstem regions, a key finding that was amplified in Fro mice. Regarding direct pharmacological effects, acute ethanol administration increased the regional cerebral blood volume (rCBV) in many brain areas. Here, chronic alcohol consumption otherwise attenuated the acute rCBV response in WT mice but enhanced it in Fro mice. Altogether, these findings suggest a differential role for NSM in acute and chronic functional brain responses to alcohol. Therefore, targeting NSM may be useful in the prevention or treatment of AUD. | ||
| 650 | 4 | |a Alcohol use disorder | |
| 650 | 4 | |a Anatomical MRI | |
| 650 | 4 | |a fMRI | |
| 650 | 4 | |a Neutral sphingomyelinase | |
| 650 | 4 | |a rCBV | |
| 650 | 4 | |a Resting state functional connectivity | |
| 700 | 1 | |a Mittmann, Claire |e verfasserin |4 aut | |
| 700 | 1 | |a Kreitz, Silke |e verfasserin |4 aut | |
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| 700 | 1 | |a Mühle, Christiane |e verfasserin |4 aut | |
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| 700 | 1 | |a Hess, Andreas |e verfasserin |4 aut | |
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10.1016/j.neuropharm.2024.109948 doi (DE-627)190226553X (DE-599)KXP190226553X DE-627 ger DE-627 rda eng Wank, Isabel 1985- verfasserin (DE-588)1078249296 (DE-627)838190413 (DE-576)449899136 aut Neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity Isabel Wank, Claire Mittmann, Silke Kreitz, Daria Chestnykh, Christiane Mühle, Johannes Kornhuber, Andreas Ludwig, Liubov S. Kalinichenko, Christian P. Müller, Andreas Hess 16 April 2024 13 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 10.09.2024 Alcohol consumption is a widespread phenomenon throughout the world. However, how recreational alcohol use evolves into alcohol use disorder (AUD) remains poorly understood. The Smpd3 gene and its coded protein neutral sphingomyelinase (NSM) are associated with alcohol consumption in humans and alcohol-related behaviors in mice, suggesting a potential role in this transition. Using multiparametric magnetic resonance imaging, we characterized the role of NSM in acute and chronic effects of alcohol on brain anatomy and function in female mice. Chronic voluntary alcohol consumption (16 vol% for at least 6 days) affected brain anatomy in WT mice, reducing regional structure volume predominantly in cortical regions. Attenuated NSM activity prevented these anatomical changes. Functional MRI linked these anatomical adaptations to functional changes: Chronic alcohol consumption in mice significantly modulated resting state functional connectivity (RS FC) in response to an acute ethanol challenge (i.p. bolus of 2 g kg−1) in heterozygous NSM knockout (Fro), but not in WT mice. Acute ethanol administration in alcohol-naïve WT mice significantly decreased RS FC in cortical and brainstem regions, a key finding that was amplified in Fro mice. Regarding direct pharmacological effects, acute ethanol administration increased the regional cerebral blood volume (rCBV) in many brain areas. Here, chronic alcohol consumption otherwise attenuated the acute rCBV response in WT mice but enhanced it in Fro mice. Altogether, these findings suggest a differential role for NSM in acute and chronic functional brain responses to alcohol. Therefore, targeting NSM may be useful in the prevention or treatment of AUD. Alcohol use disorder Anatomical MRI fMRI Neutral sphingomyelinase rCBV Resting state functional connectivity Mittmann, Claire verfasserin aut Kreitz, Silke verfasserin aut Chestnykh, Daria verfasserin aut Mühle, Christiane verfasserin aut Kornhuber, Johannes verfasserin aut Ludwig, Andreas verfasserin aut Kalinichenko, Liubov S. verfasserin aut Müller, Christian P. verfasserin (DE-588)128597127 (DE-627)527710369 (DE-576)297233890 aut Hess, Andreas verfasserin aut Enthalten in Neuropharmacology Amsterdam [u.a.] : Elsevier Science, 1970 253(2024), Artikel-ID 109948, Seite 1-13 Online-Ressource (DE-627)30666125X (DE-600)1500655-4 (DE-576)081986831 1873-7064 nnns volume:253 year:2024 elocationid:109948 pages:1-13 extent:13 https://doi.org/10.1016/j.neuropharm.2024.109948 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0028390824001175 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4315 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 253 2024 109948 1-13 13 2013 01 DE-16-250 4578533328 00 --%%-- --%%-- --%%-- --%%-- l01 10-09-24 2013 01 DE-16-250 00 s hd2024 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_10 2013 01 DE-16-250 03 s s_13 2013 01 DE-16-250 04 p (DE-627)1871553717 Müller, Christian P. 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_9 |
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10.1016/j.neuropharm.2024.109948 doi (DE-627)190226553X (DE-599)KXP190226553X DE-627 ger DE-627 rda eng Wank, Isabel 1985- verfasserin (DE-588)1078249296 (DE-627)838190413 (DE-576)449899136 aut Neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity Isabel Wank, Claire Mittmann, Silke Kreitz, Daria Chestnykh, Christiane Mühle, Johannes Kornhuber, Andreas Ludwig, Liubov S. Kalinichenko, Christian P. Müller, Andreas Hess 16 April 2024 13 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 10.09.2024 Alcohol consumption is a widespread phenomenon throughout the world. However, how recreational alcohol use evolves into alcohol use disorder (AUD) remains poorly understood. The Smpd3 gene and its coded protein neutral sphingomyelinase (NSM) are associated with alcohol consumption in humans and alcohol-related behaviors in mice, suggesting a potential role in this transition. Using multiparametric magnetic resonance imaging, we characterized the role of NSM in acute and chronic effects of alcohol on brain anatomy and function in female mice. Chronic voluntary alcohol consumption (16 vol% for at least 6 days) affected brain anatomy in WT mice, reducing regional structure volume predominantly in cortical regions. Attenuated NSM activity prevented these anatomical changes. Functional MRI linked these anatomical adaptations to functional changes: Chronic alcohol consumption in mice significantly modulated resting state functional connectivity (RS FC) in response to an acute ethanol challenge (i.p. bolus of 2 g kg−1) in heterozygous NSM knockout (Fro), but not in WT mice. Acute ethanol administration in alcohol-naïve WT mice significantly decreased RS FC in cortical and brainstem regions, a key finding that was amplified in Fro mice. Regarding direct pharmacological effects, acute ethanol administration increased the regional cerebral blood volume (rCBV) in many brain areas. Here, chronic alcohol consumption otherwise attenuated the acute rCBV response in WT mice but enhanced it in Fro mice. Altogether, these findings suggest a differential role for NSM in acute and chronic functional brain responses to alcohol. Therefore, targeting NSM may be useful in the prevention or treatment of AUD. Alcohol use disorder Anatomical MRI fMRI Neutral sphingomyelinase rCBV Resting state functional connectivity Mittmann, Claire verfasserin aut Kreitz, Silke verfasserin aut Chestnykh, Daria verfasserin aut Mühle, Christiane verfasserin aut Kornhuber, Johannes verfasserin aut Ludwig, Andreas verfasserin aut Kalinichenko, Liubov S. verfasserin aut Müller, Christian P. verfasserin (DE-588)128597127 (DE-627)527710369 (DE-576)297233890 aut Hess, Andreas verfasserin aut Enthalten in Neuropharmacology Amsterdam [u.a.] : Elsevier Science, 1970 253(2024), Artikel-ID 109948, Seite 1-13 Online-Ressource (DE-627)30666125X (DE-600)1500655-4 (DE-576)081986831 1873-7064 nnns volume:253 year:2024 elocationid:109948 pages:1-13 extent:13 https://doi.org/10.1016/j.neuropharm.2024.109948 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0028390824001175 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4315 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 253 2024 109948 1-13 13 2013 01 DE-16-250 4578533328 00 --%%-- --%%-- --%%-- --%%-- l01 10-09-24 2013 01 DE-16-250 00 s hd2024 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_10 2013 01 DE-16-250 03 s s_13 2013 01 DE-16-250 04 p (DE-627)1871553717 Müller, Christian P. 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_9 |
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10.1016/j.neuropharm.2024.109948 doi (DE-627)190226553X (DE-599)KXP190226553X DE-627 ger DE-627 rda eng Wank, Isabel 1985- verfasserin (DE-588)1078249296 (DE-627)838190413 (DE-576)449899136 aut Neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity Isabel Wank, Claire Mittmann, Silke Kreitz, Daria Chestnykh, Christiane Mühle, Johannes Kornhuber, Andreas Ludwig, Liubov S. Kalinichenko, Christian P. Müller, Andreas Hess 16 April 2024 13 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 10.09.2024 Alcohol consumption is a widespread phenomenon throughout the world. However, how recreational alcohol use evolves into alcohol use disorder (AUD) remains poorly understood. The Smpd3 gene and its coded protein neutral sphingomyelinase (NSM) are associated with alcohol consumption in humans and alcohol-related behaviors in mice, suggesting a potential role in this transition. Using multiparametric magnetic resonance imaging, we characterized the role of NSM in acute and chronic effects of alcohol on brain anatomy and function in female mice. Chronic voluntary alcohol consumption (16 vol% for at least 6 days) affected brain anatomy in WT mice, reducing regional structure volume predominantly in cortical regions. Attenuated NSM activity prevented these anatomical changes. Functional MRI linked these anatomical adaptations to functional changes: Chronic alcohol consumption in mice significantly modulated resting state functional connectivity (RS FC) in response to an acute ethanol challenge (i.p. bolus of 2 g kg−1) in heterozygous NSM knockout (Fro), but not in WT mice. Acute ethanol administration in alcohol-naïve WT mice significantly decreased RS FC in cortical and brainstem regions, a key finding that was amplified in Fro mice. Regarding direct pharmacological effects, acute ethanol administration increased the regional cerebral blood volume (rCBV) in many brain areas. Here, chronic alcohol consumption otherwise attenuated the acute rCBV response in WT mice but enhanced it in Fro mice. Altogether, these findings suggest a differential role for NSM in acute and chronic functional brain responses to alcohol. Therefore, targeting NSM may be useful in the prevention or treatment of AUD. Alcohol use disorder Anatomical MRI fMRI Neutral sphingomyelinase rCBV Resting state functional connectivity Mittmann, Claire verfasserin aut Kreitz, Silke verfasserin aut Chestnykh, Daria verfasserin aut Mühle, Christiane verfasserin aut Kornhuber, Johannes verfasserin aut Ludwig, Andreas verfasserin aut Kalinichenko, Liubov S. verfasserin aut Müller, Christian P. verfasserin (DE-588)128597127 (DE-627)527710369 (DE-576)297233890 aut Hess, Andreas verfasserin aut Enthalten in Neuropharmacology Amsterdam [u.a.] : Elsevier Science, 1970 253(2024), Artikel-ID 109948, Seite 1-13 Online-Ressource (DE-627)30666125X (DE-600)1500655-4 (DE-576)081986831 1873-7064 nnns volume:253 year:2024 elocationid:109948 pages:1-13 extent:13 https://doi.org/10.1016/j.neuropharm.2024.109948 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0028390824001175 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4315 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 253 2024 109948 1-13 13 2013 01 DE-16-250 4578533328 00 --%%-- --%%-- --%%-- --%%-- l01 10-09-24 2013 01 DE-16-250 00 s hd2024 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_10 2013 01 DE-16-250 03 s s_13 2013 01 DE-16-250 04 p (DE-627)1871553717 Müller, Christian P. 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_9 |
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10.1016/j.neuropharm.2024.109948 doi (DE-627)190226553X (DE-599)KXP190226553X DE-627 ger DE-627 rda eng Wank, Isabel 1985- verfasserin (DE-588)1078249296 (DE-627)838190413 (DE-576)449899136 aut Neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity Isabel Wank, Claire Mittmann, Silke Kreitz, Daria Chestnykh, Christiane Mühle, Johannes Kornhuber, Andreas Ludwig, Liubov S. Kalinichenko, Christian P. Müller, Andreas Hess 16 April 2024 13 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 10.09.2024 Alcohol consumption is a widespread phenomenon throughout the world. However, how recreational alcohol use evolves into alcohol use disorder (AUD) remains poorly understood. The Smpd3 gene and its coded protein neutral sphingomyelinase (NSM) are associated with alcohol consumption in humans and alcohol-related behaviors in mice, suggesting a potential role in this transition. Using multiparametric magnetic resonance imaging, we characterized the role of NSM in acute and chronic effects of alcohol on brain anatomy and function in female mice. Chronic voluntary alcohol consumption (16 vol% for at least 6 days) affected brain anatomy in WT mice, reducing regional structure volume predominantly in cortical regions. Attenuated NSM activity prevented these anatomical changes. Functional MRI linked these anatomical adaptations to functional changes: Chronic alcohol consumption in mice significantly modulated resting state functional connectivity (RS FC) in response to an acute ethanol challenge (i.p. bolus of 2 g kg−1) in heterozygous NSM knockout (Fro), but not in WT mice. Acute ethanol administration in alcohol-naïve WT mice significantly decreased RS FC in cortical and brainstem regions, a key finding that was amplified in Fro mice. Regarding direct pharmacological effects, acute ethanol administration increased the regional cerebral blood volume (rCBV) in many brain areas. Here, chronic alcohol consumption otherwise attenuated the acute rCBV response in WT mice but enhanced it in Fro mice. Altogether, these findings suggest a differential role for NSM in acute and chronic functional brain responses to alcohol. Therefore, targeting NSM may be useful in the prevention or treatment of AUD. Alcohol use disorder Anatomical MRI fMRI Neutral sphingomyelinase rCBV Resting state functional connectivity Mittmann, Claire verfasserin aut Kreitz, Silke verfasserin aut Chestnykh, Daria verfasserin aut Mühle, Christiane verfasserin aut Kornhuber, Johannes verfasserin aut Ludwig, Andreas verfasserin aut Kalinichenko, Liubov S. verfasserin aut Müller, Christian P. verfasserin (DE-588)128597127 (DE-627)527710369 (DE-576)297233890 aut Hess, Andreas verfasserin aut Enthalten in Neuropharmacology Amsterdam [u.a.] : Elsevier Science, 1970 253(2024), Artikel-ID 109948, Seite 1-13 Online-Ressource (DE-627)30666125X (DE-600)1500655-4 (DE-576)081986831 1873-7064 nnns volume:253 year:2024 elocationid:109948 pages:1-13 extent:13 https://doi.org/10.1016/j.neuropharm.2024.109948 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0028390824001175 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4315 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 253 2024 109948 1-13 13 2013 01 DE-16-250 4578533328 00 --%%-- --%%-- --%%-- --%%-- l01 10-09-24 2013 01 DE-16-250 00 s hd2024 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_10 2013 01 DE-16-250 03 s s_13 2013 01 DE-16-250 04 p (DE-627)1871553717 Müller, Christian P. 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_9 |
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10.1016/j.neuropharm.2024.109948 doi (DE-627)190226553X (DE-599)KXP190226553X DE-627 ger DE-627 rda eng Wank, Isabel 1985- verfasserin (DE-588)1078249296 (DE-627)838190413 (DE-576)449899136 aut Neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity Isabel Wank, Claire Mittmann, Silke Kreitz, Daria Chestnykh, Christiane Mühle, Johannes Kornhuber, Andreas Ludwig, Liubov S. Kalinichenko, Christian P. Müller, Andreas Hess 16 April 2024 13 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 10.09.2024 Alcohol consumption is a widespread phenomenon throughout the world. However, how recreational alcohol use evolves into alcohol use disorder (AUD) remains poorly understood. The Smpd3 gene and its coded protein neutral sphingomyelinase (NSM) are associated with alcohol consumption in humans and alcohol-related behaviors in mice, suggesting a potential role in this transition. Using multiparametric magnetic resonance imaging, we characterized the role of NSM in acute and chronic effects of alcohol on brain anatomy and function in female mice. Chronic voluntary alcohol consumption (16 vol% for at least 6 days) affected brain anatomy in WT mice, reducing regional structure volume predominantly in cortical regions. Attenuated NSM activity prevented these anatomical changes. Functional MRI linked these anatomical adaptations to functional changes: Chronic alcohol consumption in mice significantly modulated resting state functional connectivity (RS FC) in response to an acute ethanol challenge (i.p. bolus of 2 g kg−1) in heterozygous NSM knockout (Fro), but not in WT mice. Acute ethanol administration in alcohol-naïve WT mice significantly decreased RS FC in cortical and brainstem regions, a key finding that was amplified in Fro mice. Regarding direct pharmacological effects, acute ethanol administration increased the regional cerebral blood volume (rCBV) in many brain areas. Here, chronic alcohol consumption otherwise attenuated the acute rCBV response in WT mice but enhanced it in Fro mice. Altogether, these findings suggest a differential role for NSM in acute and chronic functional brain responses to alcohol. Therefore, targeting NSM may be useful in the prevention or treatment of AUD. Alcohol use disorder Anatomical MRI fMRI Neutral sphingomyelinase rCBV Resting state functional connectivity Mittmann, Claire verfasserin aut Kreitz, Silke verfasserin aut Chestnykh, Daria verfasserin aut Mühle, Christiane verfasserin aut Kornhuber, Johannes verfasserin aut Ludwig, Andreas verfasserin aut Kalinichenko, Liubov S. verfasserin aut Müller, Christian P. verfasserin (DE-588)128597127 (DE-627)527710369 (DE-576)297233890 aut Hess, Andreas verfasserin aut Enthalten in Neuropharmacology Amsterdam [u.a.] : Elsevier Science, 1970 253(2024), Artikel-ID 109948, Seite 1-13 Online-Ressource (DE-627)30666125X (DE-600)1500655-4 (DE-576)081986831 1873-7064 nnns volume:253 year:2024 elocationid:109948 pages:1-13 extent:13 https://doi.org/10.1016/j.neuropharm.2024.109948 Verlag Resolving-System lizenzpflichtig Volltext https://www.sciencedirect.com/science/article/pii/S0028390824001175 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4315 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 253 2024 109948 1-13 13 2013 01 DE-16-250 4578533328 00 --%%-- --%%-- --%%-- --%%-- l01 10-09-24 2013 01 DE-16-250 00 s hd2024 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_10 2013 01 DE-16-250 03 s s_13 2013 01 DE-16-250 04 p (DE-627)1871553717 Müller, Christian P. 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_9 |
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Kalinichenko, Christian P. Müller, Andreas Hess</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">16 April 2024</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">13</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Gesehen am 10.09.2024</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Alcohol consumption is a widespread phenomenon throughout the world. However, how recreational alcohol use evolves into alcohol use disorder (AUD) remains poorly understood. The Smpd3 gene and its coded protein neutral sphingomyelinase (NSM) are associated with alcohol consumption in humans and alcohol-related behaviors in mice, suggesting a potential role in this transition. Using multiparametric magnetic resonance imaging, we characterized the role of NSM in acute and chronic effects of alcohol on brain anatomy and function in female mice. Chronic voluntary alcohol consumption (16 vol% for at least 6 days) affected brain anatomy in WT mice, reducing regional structure volume predominantly in cortical regions. Attenuated NSM activity prevented these anatomical changes. Functional MRI linked these anatomical adaptations to functional changes: Chronic alcohol consumption in mice significantly modulated resting state functional connectivity (RS FC) in response to an acute ethanol challenge (i.p. bolus of 2 g kg−1) in heterozygous NSM knockout (Fro), but not in WT mice. Acute ethanol administration in alcohol-naïve WT mice significantly decreased RS FC in cortical and brainstem regions, a key finding that was amplified in Fro mice. Regarding direct pharmacological effects, acute ethanol administration increased the regional cerebral blood volume (rCBV) in many brain areas. Here, chronic alcohol consumption otherwise attenuated the acute rCBV response in WT mice but enhanced it in Fro mice. Altogether, these findings suggest a differential role for NSM in acute and chronic functional brain responses to alcohol. 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Wank, Isabel 1985- misc Alcohol use disorder misc Anatomical MRI misc fMRI misc Neutral sphingomyelinase misc rCBV misc Resting state functional connectivity 2013 hd2024 2013 wissenschaftlicher Artikel (Zeitschrift) 2013 per_10 2013 s_13 2013 Müller, Christian P. 2013 Extern 2013 Verfasser 2013 pos_9 Neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity |
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2013 01 DE-16-250 00 s hd2024 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_10 2013 01 DE-16-250 03 s s_13 2013 01 DE-16-250 04 p (DE-627)1871553717 Müller, Christian P. 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_9 Neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity Isabel Wank, Claire Mittmann, Silke Kreitz, Daria Chestnykh, Christiane Mühle, Johannes Kornhuber, Andreas Ludwig, Liubov S. Kalinichenko, Christian P. Müller, Andreas Hess Alcohol use disorder Anatomical MRI fMRI Neutral sphingomyelinase rCBV Resting state functional connectivity |
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Neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity |
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Neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity Isabel Wank, Claire Mittmann, Silke Kreitz, Daria Chestnykh, Christiane Mühle, Johannes Kornhuber, Andreas Ludwig, Liubov S. Kalinichenko, Christian P. Müller, Andreas Hess |
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neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity |
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Neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity |
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Alcohol consumption is a widespread phenomenon throughout the world. However, how recreational alcohol use evolves into alcohol use disorder (AUD) remains poorly understood. The Smpd3 gene and its coded protein neutral sphingomyelinase (NSM) are associated with alcohol consumption in humans and alcohol-related behaviors in mice, suggesting a potential role in this transition. Using multiparametric magnetic resonance imaging, we characterized the role of NSM in acute and chronic effects of alcohol on brain anatomy and function in female mice. Chronic voluntary alcohol consumption (16 vol% for at least 6 days) affected brain anatomy in WT mice, reducing regional structure volume predominantly in cortical regions. Attenuated NSM activity prevented these anatomical changes. Functional MRI linked these anatomical adaptations to functional changes: Chronic alcohol consumption in mice significantly modulated resting state functional connectivity (RS FC) in response to an acute ethanol challenge (i.p. bolus of 2 g kg−1) in heterozygous NSM knockout (Fro), but not in WT mice. Acute ethanol administration in alcohol-naïve WT mice significantly decreased RS FC in cortical and brainstem regions, a key finding that was amplified in Fro mice. Regarding direct pharmacological effects, acute ethanol administration increased the regional cerebral blood volume (rCBV) in many brain areas. Here, chronic alcohol consumption otherwise attenuated the acute rCBV response in WT mice but enhanced it in Fro mice. Altogether, these findings suggest a differential role for NSM in acute and chronic functional brain responses to alcohol. Therefore, targeting NSM may be useful in the prevention or treatment of AUD. Gesehen am 10.09.2024 |
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Alcohol consumption is a widespread phenomenon throughout the world. However, how recreational alcohol use evolves into alcohol use disorder (AUD) remains poorly understood. The Smpd3 gene and its coded protein neutral sphingomyelinase (NSM) are associated with alcohol consumption in humans and alcohol-related behaviors in mice, suggesting a potential role in this transition. Using multiparametric magnetic resonance imaging, we characterized the role of NSM in acute and chronic effects of alcohol on brain anatomy and function in female mice. Chronic voluntary alcohol consumption (16 vol% for at least 6 days) affected brain anatomy in WT mice, reducing regional structure volume predominantly in cortical regions. Attenuated NSM activity prevented these anatomical changes. Functional MRI linked these anatomical adaptations to functional changes: Chronic alcohol consumption in mice significantly modulated resting state functional connectivity (RS FC) in response to an acute ethanol challenge (i.p. bolus of 2 g kg−1) in heterozygous NSM knockout (Fro), but not in WT mice. Acute ethanol administration in alcohol-naïve WT mice significantly decreased RS FC in cortical and brainstem regions, a key finding that was amplified in Fro mice. Regarding direct pharmacological effects, acute ethanol administration increased the regional cerebral blood volume (rCBV) in many brain areas. Here, chronic alcohol consumption otherwise attenuated the acute rCBV response in WT mice but enhanced it in Fro mice. Altogether, these findings suggest a differential role for NSM in acute and chronic functional brain responses to alcohol. Therefore, targeting NSM may be useful in the prevention or treatment of AUD. Gesehen am 10.09.2024 |
| abstract_unstemmed |
Alcohol consumption is a widespread phenomenon throughout the world. However, how recreational alcohol use evolves into alcohol use disorder (AUD) remains poorly understood. The Smpd3 gene and its coded protein neutral sphingomyelinase (NSM) are associated with alcohol consumption in humans and alcohol-related behaviors in mice, suggesting a potential role in this transition. Using multiparametric magnetic resonance imaging, we characterized the role of NSM in acute and chronic effects of alcohol on brain anatomy and function in female mice. Chronic voluntary alcohol consumption (16 vol% for at least 6 days) affected brain anatomy in WT mice, reducing regional structure volume predominantly in cortical regions. Attenuated NSM activity prevented these anatomical changes. Functional MRI linked these anatomical adaptations to functional changes: Chronic alcohol consumption in mice significantly modulated resting state functional connectivity (RS FC) in response to an acute ethanol challenge (i.p. bolus of 2 g kg−1) in heterozygous NSM knockout (Fro), but not in WT mice. Acute ethanol administration in alcohol-naïve WT mice significantly decreased RS FC in cortical and brainstem regions, a key finding that was amplified in Fro mice. Regarding direct pharmacological effects, acute ethanol administration increased the regional cerebral blood volume (rCBV) in many brain areas. Here, chronic alcohol consumption otherwise attenuated the acute rCBV response in WT mice but enhanced it in Fro mice. Altogether, these findings suggest a differential role for NSM in acute and chronic functional brain responses to alcohol. Therefore, targeting NSM may be useful in the prevention or treatment of AUD. Gesehen am 10.09.2024 |
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