Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review

Liver cancer remains a global challenge of healthcare, with the incidence growing worldwide. According to various authors, over 1 million patients will be diagnosed with liver cancer each year by 2025. The molecular pathogenesis of HCC varies with respect to genotoxic lesions and aetiologies. Althou...
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Autor*in:	K. V. Menshikov [verfasserIn] A. V. Sultanbaev [verfasserIn] Sh. I. Musin [verfasserIn] I. R. Rakhmatullina [verfasserIn] I. A. Menshikova [verfasserIn] R. R. Abdeev [verfasserIn] N. I. Sultanbaeva [verfasserIn] E. V. Popova [verfasserIn] G. A. Serebrennikov [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Russisch

Erschienen:	2022

Schlagwörter:	гепатоцеллюлярная карцинома рак печени молекулярный патогенез драйверные мутации опухолевое микроокружение неалкогольный стеатогепатит вирусный гепатит

Übergeordnetes Werk:	In: Креативная хирургия и онкология - Bashkir State Medical University, 2019, 12(2022), 2, Seite 139-150
Übergeordnetes Werk:	volume:12 ; year:2022 ; number:2 ; pages:139-150

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.24060/2076-3093-2022-12-2-139-150

Katalog-ID:	DOAJ000284491

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allfields	10.24060/2076-3093-2022-12-2-139-150 doi (DE-627)DOAJ000284491 (DE-599)DOAJc14b45b6db8241569154b21ca73ae506 DE-627 ger DE-627 rakwb eng rus RD1-811 RC254-282 K. V. Menshikov verfasserin aut Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Liver cancer remains a global challenge of healthcare, with the incidence growing worldwide. According to various authors, over 1 million patients will be diagnosed with liver cancer each year by 2025. The molecular pathogenesis of HCC varies with respect to genotoxic lesions and aetiologies. Although our understanding of the HCC pathophysiology and drivers tends to improve, it is still distant from translation into clinical practice. About 25 % of HCC cases are associated with variant mutations. HCC pathophysiology is a complex multi-step process. The interaction of various factors underlies the early stages of malignant hepatocyte transformation towards the development of HCC. Overall, about 20–25 % of HCC patients have at least one potential driver mutation. Obesity should also be noted as being associated with a higher risk of HCC and various other cancers. Despite many issues in the HCC pathogenesis being already known, the unresolved questions remain. Modern molecular genetic diagnostics and animal modelling of malignant tumours are expanding our horizons of knowledge in this field. гепатоцеллюлярная карцинома рак печени молекулярный патогенез драйверные мутации опухолевое микроокружение неалкогольный стеатогепатит вирусный гепатит Surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens A. V. Sultanbaev verfasserin aut Sh. I. Musin verfasserin aut I. R. Rakhmatullina verfasserin aut I. A. Menshikova verfasserin aut R. R. Abdeev verfasserin aut N. I. Sultanbaeva verfasserin aut E. V. Popova verfasserin aut G. A. Serebrennikov verfasserin aut In Креативная хирургия и онкология Bashkir State Medical University, 2019 12(2022), 2, Seite 139-150 (DE-627)1760593990 23070501 nnns volume:12 year:2022 number:2 pages:139-150 https://doi.org/10.24060/2076-3093-2022-12-2-139-150 kostenfrei https://doaj.org/article/c14b45b6db8241569154b21ca73ae506 kostenfrei https://www.surgonco.ru/jour/article/view/695 kostenfrei https://doaj.org/toc/2307-0501 Journal toc kostenfrei https://doaj.org/toc/2076-3093 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 12 2022 2 139-150
spelling	10.24060/2076-3093-2022-12-2-139-150 doi (DE-627)DOAJ000284491 (DE-599)DOAJc14b45b6db8241569154b21ca73ae506 DE-627 ger DE-627 rakwb eng rus RD1-811 RC254-282 K. V. Menshikov verfasserin aut Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Liver cancer remains a global challenge of healthcare, with the incidence growing worldwide. According to various authors, over 1 million patients will be diagnosed with liver cancer each year by 2025. The molecular pathogenesis of HCC varies with respect to genotoxic lesions and aetiologies. Although our understanding of the HCC pathophysiology and drivers tends to improve, it is still distant from translation into clinical practice. About 25 % of HCC cases are associated with variant mutations. HCC pathophysiology is a complex multi-step process. The interaction of various factors underlies the early stages of malignant hepatocyte transformation towards the development of HCC. Overall, about 20–25 % of HCC patients have at least one potential driver mutation. Obesity should also be noted as being associated with a higher risk of HCC and various other cancers. Despite many issues in the HCC pathogenesis being already known, the unresolved questions remain. Modern molecular genetic diagnostics and animal modelling of malignant tumours are expanding our horizons of knowledge in this field. гепатоцеллюлярная карцинома рак печени молекулярный патогенез драйверные мутации опухолевое микроокружение неалкогольный стеатогепатит вирусный гепатит Surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens A. V. Sultanbaev verfasserin aut Sh. I. Musin verfasserin aut I. R. Rakhmatullina verfasserin aut I. A. Menshikova verfasserin aut R. R. Abdeev verfasserin aut N. I. Sultanbaeva verfasserin aut E. V. Popova verfasserin aut G. A. Serebrennikov verfasserin aut In Креативная хирургия и онкология Bashkir State Medical University, 2019 12(2022), 2, Seite 139-150 (DE-627)1760593990 23070501 nnns volume:12 year:2022 number:2 pages:139-150 https://doi.org/10.24060/2076-3093-2022-12-2-139-150 kostenfrei https://doaj.org/article/c14b45b6db8241569154b21ca73ae506 kostenfrei https://www.surgonco.ru/jour/article/view/695 kostenfrei https://doaj.org/toc/2307-0501 Journal toc kostenfrei https://doaj.org/toc/2076-3093 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 12 2022 2 139-150
allfields_unstemmed	10.24060/2076-3093-2022-12-2-139-150 doi (DE-627)DOAJ000284491 (DE-599)DOAJc14b45b6db8241569154b21ca73ae506 DE-627 ger DE-627 rakwb eng rus RD1-811 RC254-282 K. V. Menshikov verfasserin aut Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Liver cancer remains a global challenge of healthcare, with the incidence growing worldwide. According to various authors, over 1 million patients will be diagnosed with liver cancer each year by 2025. The molecular pathogenesis of HCC varies with respect to genotoxic lesions and aetiologies. Although our understanding of the HCC pathophysiology and drivers tends to improve, it is still distant from translation into clinical practice. About 25 % of HCC cases are associated with variant mutations. HCC pathophysiology is a complex multi-step process. The interaction of various factors underlies the early stages of malignant hepatocyte transformation towards the development of HCC. Overall, about 20–25 % of HCC patients have at least one potential driver mutation. Obesity should also be noted as being associated with a higher risk of HCC and various other cancers. Despite many issues in the HCC pathogenesis being already known, the unresolved questions remain. Modern molecular genetic diagnostics and animal modelling of malignant tumours are expanding our horizons of knowledge in this field. гепатоцеллюлярная карцинома рак печени молекулярный патогенез драйверные мутации опухолевое микроокружение неалкогольный стеатогепатит вирусный гепатит Surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens A. V. Sultanbaev verfasserin aut Sh. I. Musin verfasserin aut I. R. Rakhmatullina verfasserin aut I. A. Menshikova verfasserin aut R. R. Abdeev verfasserin aut N. I. Sultanbaeva verfasserin aut E. V. Popova verfasserin aut G. A. Serebrennikov verfasserin aut In Креативная хирургия и онкология Bashkir State Medical University, 2019 12(2022), 2, Seite 139-150 (DE-627)1760593990 23070501 nnns volume:12 year:2022 number:2 pages:139-150 https://doi.org/10.24060/2076-3093-2022-12-2-139-150 kostenfrei https://doaj.org/article/c14b45b6db8241569154b21ca73ae506 kostenfrei https://www.surgonco.ru/jour/article/view/695 kostenfrei https://doaj.org/toc/2307-0501 Journal toc kostenfrei https://doaj.org/toc/2076-3093 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 12 2022 2 139-150
allfieldsGer	10.24060/2076-3093-2022-12-2-139-150 doi (DE-627)DOAJ000284491 (DE-599)DOAJc14b45b6db8241569154b21ca73ae506 DE-627 ger DE-627 rakwb eng rus RD1-811 RC254-282 K. V. Menshikov verfasserin aut Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Liver cancer remains a global challenge of healthcare, with the incidence growing worldwide. According to various authors, over 1 million patients will be diagnosed with liver cancer each year by 2025. The molecular pathogenesis of HCC varies with respect to genotoxic lesions and aetiologies. Although our understanding of the HCC pathophysiology and drivers tends to improve, it is still distant from translation into clinical practice. About 25 % of HCC cases are associated with variant mutations. HCC pathophysiology is a complex multi-step process. The interaction of various factors underlies the early stages of malignant hepatocyte transformation towards the development of HCC. Overall, about 20–25 % of HCC patients have at least one potential driver mutation. Obesity should also be noted as being associated with a higher risk of HCC and various other cancers. Despite many issues in the HCC pathogenesis being already known, the unresolved questions remain. Modern molecular genetic diagnostics and animal modelling of malignant tumours are expanding our horizons of knowledge in this field. гепатоцеллюлярная карцинома рак печени молекулярный патогенез драйверные мутации опухолевое микроокружение неалкогольный стеатогепатит вирусный гепатит Surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens A. V. Sultanbaev verfasserin aut Sh. I. Musin verfasserin aut I. R. Rakhmatullina verfasserin aut I. A. Menshikova verfasserin aut R. R. Abdeev verfasserin aut N. I. Sultanbaeva verfasserin aut E. V. Popova verfasserin aut G. A. Serebrennikov verfasserin aut In Креативная хирургия и онкология Bashkir State Medical University, 2019 12(2022), 2, Seite 139-150 (DE-627)1760593990 23070501 nnns volume:12 year:2022 number:2 pages:139-150 https://doi.org/10.24060/2076-3093-2022-12-2-139-150 kostenfrei https://doaj.org/article/c14b45b6db8241569154b21ca73ae506 kostenfrei https://www.surgonco.ru/jour/article/view/695 kostenfrei https://doaj.org/toc/2307-0501 Journal toc kostenfrei https://doaj.org/toc/2076-3093 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 12 2022 2 139-150
allfieldsSound	10.24060/2076-3093-2022-12-2-139-150 doi (DE-627)DOAJ000284491 (DE-599)DOAJc14b45b6db8241569154b21ca73ae506 DE-627 ger DE-627 rakwb eng rus RD1-811 RC254-282 K. V. Menshikov verfasserin aut Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Liver cancer remains a global challenge of healthcare, with the incidence growing worldwide. According to various authors, over 1 million patients will be diagnosed with liver cancer each year by 2025. The molecular pathogenesis of HCC varies with respect to genotoxic lesions and aetiologies. Although our understanding of the HCC pathophysiology and drivers tends to improve, it is still distant from translation into clinical practice. About 25 % of HCC cases are associated with variant mutations. HCC pathophysiology is a complex multi-step process. The interaction of various factors underlies the early stages of malignant hepatocyte transformation towards the development of HCC. Overall, about 20–25 % of HCC patients have at least one potential driver mutation. Obesity should also be noted as being associated with a higher risk of HCC and various other cancers. Despite many issues in the HCC pathogenesis being already known, the unresolved questions remain. Modern molecular genetic diagnostics and animal modelling of malignant tumours are expanding our horizons of knowledge in this field. гепатоцеллюлярная карцинома рак печени молекулярный патогенез драйверные мутации опухолевое микроокружение неалкогольный стеатогепатит вирусный гепатит Surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens A. V. Sultanbaev verfasserin aut Sh. I. Musin verfasserin aut I. R. Rakhmatullina verfasserin aut I. A. Menshikova verfasserin aut R. R. Abdeev verfasserin aut N. I. Sultanbaeva verfasserin aut E. V. Popova verfasserin aut G. A. Serebrennikov verfasserin aut In Креативная хирургия и онкология Bashkir State Medical University, 2019 12(2022), 2, Seite 139-150 (DE-627)1760593990 23070501 nnns volume:12 year:2022 number:2 pages:139-150 https://doi.org/10.24060/2076-3093-2022-12-2-139-150 kostenfrei https://doaj.org/article/c14b45b6db8241569154b21ca73ae506 kostenfrei https://www.surgonco.ru/jour/article/view/695 kostenfrei https://doaj.org/toc/2307-0501 Journal toc kostenfrei https://doaj.org/toc/2076-3093 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 12 2022 2 139-150
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topic_facet	гепатоцеллюлярная карцинома рак печени молекулярный патогенез драйверные мутации опухолевое микроокружение неалкогольный стеатогепатит вирусный гепатит Surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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author	K. V. Menshikov
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topic_title	RD1-811 RC254-282 Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review гепатоцеллюлярная карцинома рак печени молекулярный патогенез драйверные мутации опухолевое микроокружение неалкогольный стеатогепатит вирусный гепатит
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title	Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review
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title_full	Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review
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author_browse	K. V. Menshikov A. V. Sultanbaev Sh. I. Musin I. R. Rakhmatullina I. A. Menshikova R. R. Abdeev N. I. Sultanbaeva E. V. Popova G. A. Serebrennikov
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title_sort	hepatocellular carcinoma: aetiology and mechanisms of development. a literature review
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title_auth	Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review
abstract	Liver cancer remains a global challenge of healthcare, with the incidence growing worldwide. According to various authors, over 1 million patients will be diagnosed with liver cancer each year by 2025. The molecular pathogenesis of HCC varies with respect to genotoxic lesions and aetiologies. Although our understanding of the HCC pathophysiology and drivers tends to improve, it is still distant from translation into clinical practice. About 25 % of HCC cases are associated with variant mutations. HCC pathophysiology is a complex multi-step process. The interaction of various factors underlies the early stages of malignant hepatocyte transformation towards the development of HCC. Overall, about 20–25 % of HCC patients have at least one potential driver mutation. Obesity should also be noted as being associated with a higher risk of HCC and various other cancers. Despite many issues in the HCC pathogenesis being already known, the unresolved questions remain. Modern molecular genetic diagnostics and animal modelling of malignant tumours are expanding our horizons of knowledge in this field.
abstractGer	Liver cancer remains a global challenge of healthcare, with the incidence growing worldwide. According to various authors, over 1 million patients will be diagnosed with liver cancer each year by 2025. The molecular pathogenesis of HCC varies with respect to genotoxic lesions and aetiologies. Although our understanding of the HCC pathophysiology and drivers tends to improve, it is still distant from translation into clinical practice. About 25 % of HCC cases are associated with variant mutations. HCC pathophysiology is a complex multi-step process. The interaction of various factors underlies the early stages of malignant hepatocyte transformation towards the development of HCC. Overall, about 20–25 % of HCC patients have at least one potential driver mutation. Obesity should also be noted as being associated with a higher risk of HCC and various other cancers. Despite many issues in the HCC pathogenesis being already known, the unresolved questions remain. Modern molecular genetic diagnostics and animal modelling of malignant tumours are expanding our horizons of knowledge in this field.
abstract_unstemmed	Liver cancer remains a global challenge of healthcare, with the incidence growing worldwide. According to various authors, over 1 million patients will be diagnosed with liver cancer each year by 2025. The molecular pathogenesis of HCC varies with respect to genotoxic lesions and aetiologies. Although our understanding of the HCC pathophysiology and drivers tends to improve, it is still distant from translation into clinical practice. About 25 % of HCC cases are associated with variant mutations. HCC pathophysiology is a complex multi-step process. The interaction of various factors underlies the early stages of malignant hepatocyte transformation towards the development of HCC. Overall, about 20–25 % of HCC patients have at least one potential driver mutation. Obesity should also be noted as being associated with a higher risk of HCC and various other cancers. Despite many issues in the HCC pathogenesis being already known, the unresolved questions remain. Modern molecular genetic diagnostics and animal modelling of malignant tumours are expanding our horizons of knowledge in this field.
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title_short	Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review
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