A Study on Comparison of Two Benzodiazepines in Treatment of Alcohol Dependence Syndrome in Nepal
Background: Benzodiazepines are regularly prescribed to treat patients in alcoholic withdrawal. After analyzing pharmacology of benzodiazepines, diazepam is faster metabolized and concentrated in the liver, as an active metabolite whereas lorazepam is metabolized in liver by conjugation and excreted...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Vijay Kaul [verfasserIn] Prithi Bahadur Rai [verfasserIn] Sikha Upadhyaya [verfasserIn] Arpana Pokhrel [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Nobel Medical College - Nobel Medical College Teaching Hospital, 2019, 11(2022), 2, Seite 62-66 |
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| Übergeordnetes Werk: |
volume:11 ; year:2022 ; number:2 ; pages:62-66 |
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Link aufrufen |
|---|
| DOI / URN: |
10.3126/jonmc.v11i2.50464 |
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| Katalog-ID: |
DOAJ000726907 |
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| 520 | |a Background: Benzodiazepines are regularly prescribed to treat patients in alcoholic withdrawal. After analyzing pharmacology of benzodiazepines, diazepam is faster metabolized and concentrated in the liver, as an active metabolite whereas lorazepam is metabolized in liver by conjugation and excreted in urine. lorazepam being a drug of choice used in patients with deranged liver functions is needed to be compared with that of diazepam. The objective of the study is the comparasion of two benzodiazepines in treatment of alcohol dependence syndrome in Nepal. Material and Methods: This was a prospective, open label study carried out in Department of Psychiatry, Nobel Medical College and Teaching Hospital, Biratnagar. 50 patients (25 in each) aged between 25 to 65 years diagnosed as alcohol dependent admitted and grouped in either diazepam or lorazepam alternatively. The doses prescribed to the diazepam group and lorazepam group are 30 mg/day and 8 mg/day respectively in divided doses. For both the treatment groups, the dose was tapered every alternate day for 10 days. The Clinical Institute Withdrawal Assessment Alcohol Scale Revised (CIWA-Ar) scale was used for withdrawal symptoms scoring on the baseline and day 10. Lab Investigations were performed but were not a part of the study. Results: Out of the Fifty patients included in the study, at day 0, the mean CIWA-Ar scores were similar in both the treatment groups: 24.38±5.03 in the diazepam group and 24.79±6.42 in the lorazepam group. There was a significant intragroup decrease in the CIWA-Ar scores measured from Day 0 to the end of 10 days (p<0.0001) in both treatment groups; there was no significant difference between the two groups Conclusion: Diazepam and lorazepam are equally effective in alcohol withdrawal detoxification. | ||
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10.3126/jonmc.v11i2.50464 doi (DE-627)DOAJ000726907 (DE-599)DOAJced93bbdef434c1db20321cdaaca3294 DE-627 ger DE-627 rakwb eng Vijay Kaul verfasserin aut A Study on Comparison of Two Benzodiazepines in Treatment of Alcohol Dependence Syndrome in Nepal 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Benzodiazepines are regularly prescribed to treat patients in alcoholic withdrawal. After analyzing pharmacology of benzodiazepines, diazepam is faster metabolized and concentrated in the liver, as an active metabolite whereas lorazepam is metabolized in liver by conjugation and excreted in urine. lorazepam being a drug of choice used in patients with deranged liver functions is needed to be compared with that of diazepam. The objective of the study is the comparasion of two benzodiazepines in treatment of alcohol dependence syndrome in Nepal. Material and Methods: This was a prospective, open label study carried out in Department of Psychiatry, Nobel Medical College and Teaching Hospital, Biratnagar. 50 patients (25 in each) aged between 25 to 65 years diagnosed as alcohol dependent admitted and grouped in either diazepam or lorazepam alternatively. The doses prescribed to the diazepam group and lorazepam group are 30 mg/day and 8 mg/day respectively in divided doses. For both the treatment groups, the dose was tapered every alternate day for 10 days. The Clinical Institute Withdrawal Assessment Alcohol Scale Revised (CIWA-Ar) scale was used for withdrawal symptoms scoring on the baseline and day 10. Lab Investigations were performed but were not a part of the study. Results: Out of the Fifty patients included in the study, at day 0, the mean CIWA-Ar scores were similar in both the treatment groups: 24.38±5.03 in the diazepam group and 24.79±6.42 in the lorazepam group. There was a significant intragroup decrease in the CIWA-Ar scores measured from Day 0 to the end of 10 days (p<0.0001) in both treatment groups; there was no significant difference between the two groups Conclusion: Diazepam and lorazepam are equally effective in alcohol withdrawal detoxification. benzodiazepines lorazepam diazepam Medicine R Prithi Bahadur Rai verfasserin aut Sikha Upadhyaya verfasserin aut Arpana Pokhrel verfasserin aut In Journal of Nobel Medical College Nobel Medical College Teaching Hospital, 2019 11(2022), 2, Seite 62-66 (DE-627)1760650129 2091234X nnns volume:11 year:2022 number:2 pages:62-66 https://doi.org/10.3126/jonmc.v11i2.50464 kostenfrei https://doaj.org/article/ced93bbdef434c1db20321cdaaca3294 kostenfrei https://www.nepjol.info/index.php/JoNMC/article/view/50464 kostenfrei https://doaj.org/toc/2091-2331 Journal toc kostenfrei https://doaj.org/toc/2091-234X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 11 2022 2 62-66 |
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10.3126/jonmc.v11i2.50464 doi (DE-627)DOAJ000726907 (DE-599)DOAJced93bbdef434c1db20321cdaaca3294 DE-627 ger DE-627 rakwb eng Vijay Kaul verfasserin aut A Study on Comparison of Two Benzodiazepines in Treatment of Alcohol Dependence Syndrome in Nepal 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Benzodiazepines are regularly prescribed to treat patients in alcoholic withdrawal. After analyzing pharmacology of benzodiazepines, diazepam is faster metabolized and concentrated in the liver, as an active metabolite whereas lorazepam is metabolized in liver by conjugation and excreted in urine. lorazepam being a drug of choice used in patients with deranged liver functions is needed to be compared with that of diazepam. The objective of the study is the comparasion of two benzodiazepines in treatment of alcohol dependence syndrome in Nepal. Material and Methods: This was a prospective, open label study carried out in Department of Psychiatry, Nobel Medical College and Teaching Hospital, Biratnagar. 50 patients (25 in each) aged between 25 to 65 years diagnosed as alcohol dependent admitted and grouped in either diazepam or lorazepam alternatively. The doses prescribed to the diazepam group and lorazepam group are 30 mg/day and 8 mg/day respectively in divided doses. For both the treatment groups, the dose was tapered every alternate day for 10 days. The Clinical Institute Withdrawal Assessment Alcohol Scale Revised (CIWA-Ar) scale was used for withdrawal symptoms scoring on the baseline and day 10. Lab Investigations were performed but were not a part of the study. Results: Out of the Fifty patients included in the study, at day 0, the mean CIWA-Ar scores were similar in both the treatment groups: 24.38±5.03 in the diazepam group and 24.79±6.42 in the lorazepam group. There was a significant intragroup decrease in the CIWA-Ar scores measured from Day 0 to the end of 10 days (p<0.0001) in both treatment groups; there was no significant difference between the two groups Conclusion: Diazepam and lorazepam are equally effective in alcohol withdrawal detoxification. benzodiazepines lorazepam diazepam Medicine R Prithi Bahadur Rai verfasserin aut Sikha Upadhyaya verfasserin aut Arpana Pokhrel verfasserin aut In Journal of Nobel Medical College Nobel Medical College Teaching Hospital, 2019 11(2022), 2, Seite 62-66 (DE-627)1760650129 2091234X nnns volume:11 year:2022 number:2 pages:62-66 https://doi.org/10.3126/jonmc.v11i2.50464 kostenfrei https://doaj.org/article/ced93bbdef434c1db20321cdaaca3294 kostenfrei https://www.nepjol.info/index.php/JoNMC/article/view/50464 kostenfrei https://doaj.org/toc/2091-2331 Journal toc kostenfrei https://doaj.org/toc/2091-234X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 11 2022 2 62-66 |
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10.3126/jonmc.v11i2.50464 doi (DE-627)DOAJ000726907 (DE-599)DOAJced93bbdef434c1db20321cdaaca3294 DE-627 ger DE-627 rakwb eng Vijay Kaul verfasserin aut A Study on Comparison of Two Benzodiazepines in Treatment of Alcohol Dependence Syndrome in Nepal 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Benzodiazepines are regularly prescribed to treat patients in alcoholic withdrawal. After analyzing pharmacology of benzodiazepines, diazepam is faster metabolized and concentrated in the liver, as an active metabolite whereas lorazepam is metabolized in liver by conjugation and excreted in urine. lorazepam being a drug of choice used in patients with deranged liver functions is needed to be compared with that of diazepam. The objective of the study is the comparasion of two benzodiazepines in treatment of alcohol dependence syndrome in Nepal. Material and Methods: This was a prospective, open label study carried out in Department of Psychiatry, Nobel Medical College and Teaching Hospital, Biratnagar. 50 patients (25 in each) aged between 25 to 65 years diagnosed as alcohol dependent admitted and grouped in either diazepam or lorazepam alternatively. The doses prescribed to the diazepam group and lorazepam group are 30 mg/day and 8 mg/day respectively in divided doses. For both the treatment groups, the dose was tapered every alternate day for 10 days. The Clinical Institute Withdrawal Assessment Alcohol Scale Revised (CIWA-Ar) scale was used for withdrawal symptoms scoring on the baseline and day 10. Lab Investigations were performed but were not a part of the study. Results: Out of the Fifty patients included in the study, at day 0, the mean CIWA-Ar scores were similar in both the treatment groups: 24.38±5.03 in the diazepam group and 24.79±6.42 in the lorazepam group. There was a significant intragroup decrease in the CIWA-Ar scores measured from Day 0 to the end of 10 days (p<0.0001) in both treatment groups; there was no significant difference between the two groups Conclusion: Diazepam and lorazepam are equally effective in alcohol withdrawal detoxification. benzodiazepines lorazepam diazepam Medicine R Prithi Bahadur Rai verfasserin aut Sikha Upadhyaya verfasserin aut Arpana Pokhrel verfasserin aut In Journal of Nobel Medical College Nobel Medical College Teaching Hospital, 2019 11(2022), 2, Seite 62-66 (DE-627)1760650129 2091234X nnns volume:11 year:2022 number:2 pages:62-66 https://doi.org/10.3126/jonmc.v11i2.50464 kostenfrei https://doaj.org/article/ced93bbdef434c1db20321cdaaca3294 kostenfrei https://www.nepjol.info/index.php/JoNMC/article/view/50464 kostenfrei https://doaj.org/toc/2091-2331 Journal toc kostenfrei https://doaj.org/toc/2091-234X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 11 2022 2 62-66 |
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10.3126/jonmc.v11i2.50464 doi (DE-627)DOAJ000726907 (DE-599)DOAJced93bbdef434c1db20321cdaaca3294 DE-627 ger DE-627 rakwb eng Vijay Kaul verfasserin aut A Study on Comparison of Two Benzodiazepines in Treatment of Alcohol Dependence Syndrome in Nepal 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Benzodiazepines are regularly prescribed to treat patients in alcoholic withdrawal. After analyzing pharmacology of benzodiazepines, diazepam is faster metabolized and concentrated in the liver, as an active metabolite whereas lorazepam is metabolized in liver by conjugation and excreted in urine. lorazepam being a drug of choice used in patients with deranged liver functions is needed to be compared with that of diazepam. The objective of the study is the comparasion of two benzodiazepines in treatment of alcohol dependence syndrome in Nepal. Material and Methods: This was a prospective, open label study carried out in Department of Psychiatry, Nobel Medical College and Teaching Hospital, Biratnagar. 50 patients (25 in each) aged between 25 to 65 years diagnosed as alcohol dependent admitted and grouped in either diazepam or lorazepam alternatively. The doses prescribed to the diazepam group and lorazepam group are 30 mg/day and 8 mg/day respectively in divided doses. For both the treatment groups, the dose was tapered every alternate day for 10 days. The Clinical Institute Withdrawal Assessment Alcohol Scale Revised (CIWA-Ar) scale was used for withdrawal symptoms scoring on the baseline and day 10. Lab Investigations were performed but were not a part of the study. Results: Out of the Fifty patients included in the study, at day 0, the mean CIWA-Ar scores were similar in both the treatment groups: 24.38±5.03 in the diazepam group and 24.79±6.42 in the lorazepam group. There was a significant intragroup decrease in the CIWA-Ar scores measured from Day 0 to the end of 10 days (p<0.0001) in both treatment groups; there was no significant difference between the two groups Conclusion: Diazepam and lorazepam are equally effective in alcohol withdrawal detoxification. benzodiazepines lorazepam diazepam Medicine R Prithi Bahadur Rai verfasserin aut Sikha Upadhyaya verfasserin aut Arpana Pokhrel verfasserin aut In Journal of Nobel Medical College Nobel Medical College Teaching Hospital, 2019 11(2022), 2, Seite 62-66 (DE-627)1760650129 2091234X nnns volume:11 year:2022 number:2 pages:62-66 https://doi.org/10.3126/jonmc.v11i2.50464 kostenfrei https://doaj.org/article/ced93bbdef434c1db20321cdaaca3294 kostenfrei https://www.nepjol.info/index.php/JoNMC/article/view/50464 kostenfrei https://doaj.org/toc/2091-2331 Journal toc kostenfrei https://doaj.org/toc/2091-234X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 11 2022 2 62-66 |
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10.3126/jonmc.v11i2.50464 doi (DE-627)DOAJ000726907 (DE-599)DOAJced93bbdef434c1db20321cdaaca3294 DE-627 ger DE-627 rakwb eng Vijay Kaul verfasserin aut A Study on Comparison of Two Benzodiazepines in Treatment of Alcohol Dependence Syndrome in Nepal 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Benzodiazepines are regularly prescribed to treat patients in alcoholic withdrawal. After analyzing pharmacology of benzodiazepines, diazepam is faster metabolized and concentrated in the liver, as an active metabolite whereas lorazepam is metabolized in liver by conjugation and excreted in urine. lorazepam being a drug of choice used in patients with deranged liver functions is needed to be compared with that of diazepam. The objective of the study is the comparasion of two benzodiazepines in treatment of alcohol dependence syndrome in Nepal. Material and Methods: This was a prospective, open label study carried out in Department of Psychiatry, Nobel Medical College and Teaching Hospital, Biratnagar. 50 patients (25 in each) aged between 25 to 65 years diagnosed as alcohol dependent admitted and grouped in either diazepam or lorazepam alternatively. The doses prescribed to the diazepam group and lorazepam group are 30 mg/day and 8 mg/day respectively in divided doses. For both the treatment groups, the dose was tapered every alternate day for 10 days. The Clinical Institute Withdrawal Assessment Alcohol Scale Revised (CIWA-Ar) scale was used for withdrawal symptoms scoring on the baseline and day 10. Lab Investigations were performed but were not a part of the study. Results: Out of the Fifty patients included in the study, at day 0, the mean CIWA-Ar scores were similar in both the treatment groups: 24.38±5.03 in the diazepam group and 24.79±6.42 in the lorazepam group. There was a significant intragroup decrease in the CIWA-Ar scores measured from Day 0 to the end of 10 days (p<0.0001) in both treatment groups; there was no significant difference between the two groups Conclusion: Diazepam and lorazepam are equally effective in alcohol withdrawal detoxification. benzodiazepines lorazepam diazepam Medicine R Prithi Bahadur Rai verfasserin aut Sikha Upadhyaya verfasserin aut Arpana Pokhrel verfasserin aut In Journal of Nobel Medical College Nobel Medical College Teaching Hospital, 2019 11(2022), 2, Seite 62-66 (DE-627)1760650129 2091234X nnns volume:11 year:2022 number:2 pages:62-66 https://doi.org/10.3126/jonmc.v11i2.50464 kostenfrei https://doaj.org/article/ced93bbdef434c1db20321cdaaca3294 kostenfrei https://www.nepjol.info/index.php/JoNMC/article/view/50464 kostenfrei https://doaj.org/toc/2091-2331 Journal toc kostenfrei https://doaj.org/toc/2091-234X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 11 2022 2 62-66 |
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After analyzing pharmacology of benzodiazepines, diazepam is faster metabolized and concentrated in the liver, as an active metabolite whereas lorazepam is metabolized in liver by conjugation and excreted in urine. lorazepam being a drug of choice used in patients with deranged liver functions is needed to be compared with that of diazepam. The objective of the study is the comparasion of two benzodiazepines in treatment of alcohol dependence syndrome in Nepal. Material and Methods: This was a prospective, open label study carried out in Department of Psychiatry, Nobel Medical College and Teaching Hospital, Biratnagar. 50 patients (25 in each) aged between 25 to 65 years diagnosed as alcohol dependent admitted and grouped in either diazepam or lorazepam alternatively. The doses prescribed to the diazepam group and lorazepam group are 30 mg/day and 8 mg/day respectively in divided doses. For both the treatment groups, the dose was tapered every alternate day for 10 days. The Clinical Institute Withdrawal Assessment Alcohol Scale Revised (CIWA-Ar) scale was used for withdrawal symptoms scoring on the baseline and day 10. Lab Investigations were performed but were not a part of the study. Results: Out of the Fifty patients included in the study, at day 0, the mean CIWA-Ar scores were similar in both the treatment groups: 24.38±5.03 in the diazepam group and 24.79±6.42 in the lorazepam group. 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A Study on Comparison of Two Benzodiazepines in Treatment of Alcohol Dependence Syndrome in Nepal |
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Background: Benzodiazepines are regularly prescribed to treat patients in alcoholic withdrawal. After analyzing pharmacology of benzodiazepines, diazepam is faster metabolized and concentrated in the liver, as an active metabolite whereas lorazepam is metabolized in liver by conjugation and excreted in urine. lorazepam being a drug of choice used in patients with deranged liver functions is needed to be compared with that of diazepam. The objective of the study is the comparasion of two benzodiazepines in treatment of alcohol dependence syndrome in Nepal. Material and Methods: This was a prospective, open label study carried out in Department of Psychiatry, Nobel Medical College and Teaching Hospital, Biratnagar. 50 patients (25 in each) aged between 25 to 65 years diagnosed as alcohol dependent admitted and grouped in either diazepam or lorazepam alternatively. The doses prescribed to the diazepam group and lorazepam group are 30 mg/day and 8 mg/day respectively in divided doses. For both the treatment groups, the dose was tapered every alternate day for 10 days. The Clinical Institute Withdrawal Assessment Alcohol Scale Revised (CIWA-Ar) scale was used for withdrawal symptoms scoring on the baseline and day 10. Lab Investigations were performed but were not a part of the study. Results: Out of the Fifty patients included in the study, at day 0, the mean CIWA-Ar scores were similar in both the treatment groups: 24.38±5.03 in the diazepam group and 24.79±6.42 in the lorazepam group. There was a significant intragroup decrease in the CIWA-Ar scores measured from Day 0 to the end of 10 days (p<0.0001) in both treatment groups; there was no significant difference between the two groups Conclusion: Diazepam and lorazepam are equally effective in alcohol withdrawal detoxification. |
| abstractGer |
Background: Benzodiazepines are regularly prescribed to treat patients in alcoholic withdrawal. After analyzing pharmacology of benzodiazepines, diazepam is faster metabolized and concentrated in the liver, as an active metabolite whereas lorazepam is metabolized in liver by conjugation and excreted in urine. lorazepam being a drug of choice used in patients with deranged liver functions is needed to be compared with that of diazepam. The objective of the study is the comparasion of two benzodiazepines in treatment of alcohol dependence syndrome in Nepal. Material and Methods: This was a prospective, open label study carried out in Department of Psychiatry, Nobel Medical College and Teaching Hospital, Biratnagar. 50 patients (25 in each) aged between 25 to 65 years diagnosed as alcohol dependent admitted and grouped in either diazepam or lorazepam alternatively. The doses prescribed to the diazepam group and lorazepam group are 30 mg/day and 8 mg/day respectively in divided doses. For both the treatment groups, the dose was tapered every alternate day for 10 days. The Clinical Institute Withdrawal Assessment Alcohol Scale Revised (CIWA-Ar) scale was used for withdrawal symptoms scoring on the baseline and day 10. Lab Investigations were performed but were not a part of the study. Results: Out of the Fifty patients included in the study, at day 0, the mean CIWA-Ar scores were similar in both the treatment groups: 24.38±5.03 in the diazepam group and 24.79±6.42 in the lorazepam group. There was a significant intragroup decrease in the CIWA-Ar scores measured from Day 0 to the end of 10 days (p<0.0001) in both treatment groups; there was no significant difference between the two groups Conclusion: Diazepam and lorazepam are equally effective in alcohol withdrawal detoxification. |
| abstract_unstemmed |
Background: Benzodiazepines are regularly prescribed to treat patients in alcoholic withdrawal. After analyzing pharmacology of benzodiazepines, diazepam is faster metabolized and concentrated in the liver, as an active metabolite whereas lorazepam is metabolized in liver by conjugation and excreted in urine. lorazepam being a drug of choice used in patients with deranged liver functions is needed to be compared with that of diazepam. The objective of the study is the comparasion of two benzodiazepines in treatment of alcohol dependence syndrome in Nepal. Material and Methods: This was a prospective, open label study carried out in Department of Psychiatry, Nobel Medical College and Teaching Hospital, Biratnagar. 50 patients (25 in each) aged between 25 to 65 years diagnosed as alcohol dependent admitted and grouped in either diazepam or lorazepam alternatively. The doses prescribed to the diazepam group and lorazepam group are 30 mg/day and 8 mg/day respectively in divided doses. For both the treatment groups, the dose was tapered every alternate day for 10 days. The Clinical Institute Withdrawal Assessment Alcohol Scale Revised (CIWA-Ar) scale was used for withdrawal symptoms scoring on the baseline and day 10. Lab Investigations were performed but were not a part of the study. Results: Out of the Fifty patients included in the study, at day 0, the mean CIWA-Ar scores were similar in both the treatment groups: 24.38±5.03 in the diazepam group and 24.79±6.42 in the lorazepam group. There was a significant intragroup decrease in the CIWA-Ar scores measured from Day 0 to the end of 10 days (p<0.0001) in both treatment groups; there was no significant difference between the two groups Conclusion: Diazepam and lorazepam are equally effective in alcohol withdrawal detoxification. |
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