Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection

Abstract Background Approximately 85–90% of congenital cytomegalovirus infections (cCMV) are asymptomatic. Few studies have investigated early and long-term neurodevelopmental outcomes in children with asymptomatic cCMV (acCMV), and the data is contradictory. In the present study, we did investigate...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Maria Novelli [verfasserIn] Fabio Natale [verfasserIn] Anna Di Norcia [verfasserIn] Arianna Boiani [verfasserIn] Sara Temofonte [verfasserIn] Francesca Calandriello [verfasserIn] Cristina Zitarelli [verfasserIn] Barbara Caravale [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Congenital CMV Neurodevelopmental outcome Neurological outcome Bayley-III

Übergeordnetes Werk:	In: Italian Journal of Pediatrics - BMC, 2004, 48(2022), 1, Seite 7
Übergeordnetes Werk:	volume:48 ; year:2022 ; number:1 ; pages:7

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s13052-022-01387-3

Katalog-ID:	DOAJ00080522X

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520			\|a Abstract Background Approximately 85–90% of congenital cytomegalovirus infections (cCMV) are asymptomatic. Few studies have investigated early and long-term neurodevelopmental outcomes in children with asymptomatic cCMV (acCMV), and the data is contradictory. In the present study, we did investigate the effect of cCMV asymptomatic infection on neurological outcomes and in cognitive, language and motor development at 6 months of age. Methods Fifty-six children with cCMV asymptomatic infection were followed for 6 months, as part of a long-term surveillance program, examining their neurological and developmental outcomes. Neurological examination and Bayley-III Scales were performed. Results Clinical evaluation revealed that early neurological outcomes were essentially normal, with minor neurological deficits (i.e., tone abnormalities) in a subgroup of patients. Bayley-III scores were substantially in the normal range, with 14% showing a score less than 85 (-1SD) in the Motor Scale. Children's neurological and neurodevelopmental outcomes at 6 months of age did not differ according to the trimester of infection. Conclusions Some infants with cCMV asymptomatic infection may present minor neurological abnormalities in early stages of life. It seems useful to monitor this population for early and late neurodevelopmental sequelae.
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allfields	10.1186/s13052-022-01387-3 doi (DE-627)DOAJ00080522X (DE-599)DOAJeab5ee8da61449a598dbaa8613641730 DE-627 ger DE-627 rakwb eng RJ1-570 Maria Novelli verfasserin aut Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Approximately 85–90% of congenital cytomegalovirus infections (cCMV) are asymptomatic. Few studies have investigated early and long-term neurodevelopmental outcomes in children with asymptomatic cCMV (acCMV), and the data is contradictory. In the present study, we did investigate the effect of cCMV asymptomatic infection on neurological outcomes and in cognitive, language and motor development at 6 months of age. Methods Fifty-six children with cCMV asymptomatic infection were followed for 6 months, as part of a long-term surveillance program, examining their neurological and developmental outcomes. Neurological examination and Bayley-III Scales were performed. Results Clinical evaluation revealed that early neurological outcomes were essentially normal, with minor neurological deficits (i.e., tone abnormalities) in a subgroup of patients. Bayley-III scores were substantially in the normal range, with 14% showing a score less than 85 (-1SD) in the Motor Scale. Children's neurological and neurodevelopmental outcomes at 6 months of age did not differ according to the trimester of infection. Conclusions Some infants with cCMV asymptomatic infection may present minor neurological abnormalities in early stages of life. It seems useful to monitor this population for early and late neurodevelopmental sequelae. Congenital CMV Neurodevelopmental outcome Neurological outcome Bayley-III Pediatrics Fabio Natale verfasserin aut Anna Di Norcia verfasserin aut Arianna Boiani verfasserin aut Sara Temofonte verfasserin aut Francesca Calandriello verfasserin aut Cristina Zitarelli verfasserin aut Barbara Caravale verfasserin aut In Italian Journal of Pediatrics BMC, 2004 48(2022), 1, Seite 7 (DE-627)352108029 (DE-600)2084688-5 18247288 nnns volume:48 year:2022 number:1 pages:7 https://doi.org/10.1186/s13052-022-01387-3 kostenfrei https://doaj.org/article/eab5ee8da61449a598dbaa8613641730 kostenfrei https://doi.org/10.1186/s13052-022-01387-3 kostenfrei https://doaj.org/toc/1824-7288 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 48 2022 1 7
spelling	10.1186/s13052-022-01387-3 doi (DE-627)DOAJ00080522X (DE-599)DOAJeab5ee8da61449a598dbaa8613641730 DE-627 ger DE-627 rakwb eng RJ1-570 Maria Novelli verfasserin aut Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Approximately 85–90% of congenital cytomegalovirus infections (cCMV) are asymptomatic. Few studies have investigated early and long-term neurodevelopmental outcomes in children with asymptomatic cCMV (acCMV), and the data is contradictory. In the present study, we did investigate the effect of cCMV asymptomatic infection on neurological outcomes and in cognitive, language and motor development at 6 months of age. Methods Fifty-six children with cCMV asymptomatic infection were followed for 6 months, as part of a long-term surveillance program, examining their neurological and developmental outcomes. Neurological examination and Bayley-III Scales were performed. Results Clinical evaluation revealed that early neurological outcomes were essentially normal, with minor neurological deficits (i.e., tone abnormalities) in a subgroup of patients. Bayley-III scores were substantially in the normal range, with 14% showing a score less than 85 (-1SD) in the Motor Scale. Children's neurological and neurodevelopmental outcomes at 6 months of age did not differ according to the trimester of infection. Conclusions Some infants with cCMV asymptomatic infection may present minor neurological abnormalities in early stages of life. It seems useful to monitor this population for early and late neurodevelopmental sequelae. Congenital CMV Neurodevelopmental outcome Neurological outcome Bayley-III Pediatrics Fabio Natale verfasserin aut Anna Di Norcia verfasserin aut Arianna Boiani verfasserin aut Sara Temofonte verfasserin aut Francesca Calandriello verfasserin aut Cristina Zitarelli verfasserin aut Barbara Caravale verfasserin aut In Italian Journal of Pediatrics BMC, 2004 48(2022), 1, Seite 7 (DE-627)352108029 (DE-600)2084688-5 18247288 nnns volume:48 year:2022 number:1 pages:7 https://doi.org/10.1186/s13052-022-01387-3 kostenfrei https://doaj.org/article/eab5ee8da61449a598dbaa8613641730 kostenfrei https://doi.org/10.1186/s13052-022-01387-3 kostenfrei https://doaj.org/toc/1824-7288 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 48 2022 1 7
allfields_unstemmed	10.1186/s13052-022-01387-3 doi (DE-627)DOAJ00080522X (DE-599)DOAJeab5ee8da61449a598dbaa8613641730 DE-627 ger DE-627 rakwb eng RJ1-570 Maria Novelli verfasserin aut Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Approximately 85–90% of congenital cytomegalovirus infections (cCMV) are asymptomatic. Few studies have investigated early and long-term neurodevelopmental outcomes in children with asymptomatic cCMV (acCMV), and the data is contradictory. In the present study, we did investigate the effect of cCMV asymptomatic infection on neurological outcomes and in cognitive, language and motor development at 6 months of age. Methods Fifty-six children with cCMV asymptomatic infection were followed for 6 months, as part of a long-term surveillance program, examining their neurological and developmental outcomes. Neurological examination and Bayley-III Scales were performed. Results Clinical evaluation revealed that early neurological outcomes were essentially normal, with minor neurological deficits (i.e., tone abnormalities) in a subgroup of patients. Bayley-III scores were substantially in the normal range, with 14% showing a score less than 85 (-1SD) in the Motor Scale. Children's neurological and neurodevelopmental outcomes at 6 months of age did not differ according to the trimester of infection. Conclusions Some infants with cCMV asymptomatic infection may present minor neurological abnormalities in early stages of life. It seems useful to monitor this population for early and late neurodevelopmental sequelae. Congenital CMV Neurodevelopmental outcome Neurological outcome Bayley-III Pediatrics Fabio Natale verfasserin aut Anna Di Norcia verfasserin aut Arianna Boiani verfasserin aut Sara Temofonte verfasserin aut Francesca Calandriello verfasserin aut Cristina Zitarelli verfasserin aut Barbara Caravale verfasserin aut In Italian Journal of Pediatrics BMC, 2004 48(2022), 1, Seite 7 (DE-627)352108029 (DE-600)2084688-5 18247288 nnns volume:48 year:2022 number:1 pages:7 https://doi.org/10.1186/s13052-022-01387-3 kostenfrei https://doaj.org/article/eab5ee8da61449a598dbaa8613641730 kostenfrei https://doi.org/10.1186/s13052-022-01387-3 kostenfrei https://doaj.org/toc/1824-7288 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 48 2022 1 7
allfieldsGer	10.1186/s13052-022-01387-3 doi (DE-627)DOAJ00080522X (DE-599)DOAJeab5ee8da61449a598dbaa8613641730 DE-627 ger DE-627 rakwb eng RJ1-570 Maria Novelli verfasserin aut Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Approximately 85–90% of congenital cytomegalovirus infections (cCMV) are asymptomatic. Few studies have investigated early and long-term neurodevelopmental outcomes in children with asymptomatic cCMV (acCMV), and the data is contradictory. In the present study, we did investigate the effect of cCMV asymptomatic infection on neurological outcomes and in cognitive, language and motor development at 6 months of age. Methods Fifty-six children with cCMV asymptomatic infection were followed for 6 months, as part of a long-term surveillance program, examining their neurological and developmental outcomes. Neurological examination and Bayley-III Scales were performed. Results Clinical evaluation revealed that early neurological outcomes were essentially normal, with minor neurological deficits (i.e., tone abnormalities) in a subgroup of patients. Bayley-III scores were substantially in the normal range, with 14% showing a score less than 85 (-1SD) in the Motor Scale. Children's neurological and neurodevelopmental outcomes at 6 months of age did not differ according to the trimester of infection. Conclusions Some infants with cCMV asymptomatic infection may present minor neurological abnormalities in early stages of life. It seems useful to monitor this population for early and late neurodevelopmental sequelae. Congenital CMV Neurodevelopmental outcome Neurological outcome Bayley-III Pediatrics Fabio Natale verfasserin aut Anna Di Norcia verfasserin aut Arianna Boiani verfasserin aut Sara Temofonte verfasserin aut Francesca Calandriello verfasserin aut Cristina Zitarelli verfasserin aut Barbara Caravale verfasserin aut In Italian Journal of Pediatrics BMC, 2004 48(2022), 1, Seite 7 (DE-627)352108029 (DE-600)2084688-5 18247288 nnns volume:48 year:2022 number:1 pages:7 https://doi.org/10.1186/s13052-022-01387-3 kostenfrei https://doaj.org/article/eab5ee8da61449a598dbaa8613641730 kostenfrei https://doi.org/10.1186/s13052-022-01387-3 kostenfrei https://doaj.org/toc/1824-7288 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 48 2022 1 7
allfieldsSound	10.1186/s13052-022-01387-3 doi (DE-627)DOAJ00080522X (DE-599)DOAJeab5ee8da61449a598dbaa8613641730 DE-627 ger DE-627 rakwb eng RJ1-570 Maria Novelli verfasserin aut Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Approximately 85–90% of congenital cytomegalovirus infections (cCMV) are asymptomatic. Few studies have investigated early and long-term neurodevelopmental outcomes in children with asymptomatic cCMV (acCMV), and the data is contradictory. In the present study, we did investigate the effect of cCMV asymptomatic infection on neurological outcomes and in cognitive, language and motor development at 6 months of age. Methods Fifty-six children with cCMV asymptomatic infection were followed for 6 months, as part of a long-term surveillance program, examining their neurological and developmental outcomes. Neurological examination and Bayley-III Scales were performed. Results Clinical evaluation revealed that early neurological outcomes were essentially normal, with minor neurological deficits (i.e., tone abnormalities) in a subgroup of patients. Bayley-III scores were substantially in the normal range, with 14% showing a score less than 85 (-1SD) in the Motor Scale. Children's neurological and neurodevelopmental outcomes at 6 months of age did not differ according to the trimester of infection. Conclusions Some infants with cCMV asymptomatic infection may present minor neurological abnormalities in early stages of life. It seems useful to monitor this population for early and late neurodevelopmental sequelae. Congenital CMV Neurodevelopmental outcome Neurological outcome Bayley-III Pediatrics Fabio Natale verfasserin aut Anna Di Norcia verfasserin aut Arianna Boiani verfasserin aut Sara Temofonte verfasserin aut Francesca Calandriello verfasserin aut Cristina Zitarelli verfasserin aut Barbara Caravale verfasserin aut In Italian Journal of Pediatrics BMC, 2004 48(2022), 1, Seite 7 (DE-627)352108029 (DE-600)2084688-5 18247288 nnns volume:48 year:2022 number:1 pages:7 https://doi.org/10.1186/s13052-022-01387-3 kostenfrei https://doaj.org/article/eab5ee8da61449a598dbaa8613641730 kostenfrei https://doi.org/10.1186/s13052-022-01387-3 kostenfrei https://doaj.org/toc/1824-7288 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 48 2022 1 7
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Children's neurological and neurodevelopmental outcomes at 6 months of age did not differ according to the trimester of infection. Conclusions Some infants with cCMV asymptomatic infection may present minor neurological abnormalities in early stages of life. 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callnumber-first	R - Medicine
author	Maria Novelli
spellingShingle	Maria Novelli misc RJ1-570 misc Congenital CMV misc Neurodevelopmental outcome misc Neurological outcome misc Bayley-III misc Pediatrics Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection
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topic_title	RJ1-570 Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection Congenital CMV Neurodevelopmental outcome Neurological outcome Bayley-III
topic	misc RJ1-570 misc Congenital CMV misc Neurodevelopmental outcome misc Neurological outcome misc Bayley-III misc Pediatrics
topic_unstemmed	misc RJ1-570 misc Congenital CMV misc Neurodevelopmental outcome misc Neurological outcome misc Bayley-III misc Pediatrics
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title	Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection
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title_full	Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection
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author_browse	Maria Novelli Fabio Natale Anna Di Norcia Arianna Boiani Sara Temofonte Francesca Calandriello Cristina Zitarelli Barbara Caravale
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title_sort	early neurodevelopmental outcomes in children with asymptomatic congenital cmv infection
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title_auth	Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection
abstract	Abstract Background Approximately 85–90% of congenital cytomegalovirus infections (cCMV) are asymptomatic. Few studies have investigated early and long-term neurodevelopmental outcomes in children with asymptomatic cCMV (acCMV), and the data is contradictory. In the present study, we did investigate the effect of cCMV asymptomatic infection on neurological outcomes and in cognitive, language and motor development at 6 months of age. Methods Fifty-six children with cCMV asymptomatic infection were followed for 6 months, as part of a long-term surveillance program, examining their neurological and developmental outcomes. Neurological examination and Bayley-III Scales were performed. Results Clinical evaluation revealed that early neurological outcomes were essentially normal, with minor neurological deficits (i.e., tone abnormalities) in a subgroup of patients. Bayley-III scores were substantially in the normal range, with 14% showing a score less than 85 (-1SD) in the Motor Scale. Children's neurological and neurodevelopmental outcomes at 6 months of age did not differ according to the trimester of infection. Conclusions Some infants with cCMV asymptomatic infection may present minor neurological abnormalities in early stages of life. It seems useful to monitor this population for early and late neurodevelopmental sequelae.
abstractGer	Abstract Background Approximately 85–90% of congenital cytomegalovirus infections (cCMV) are asymptomatic. Few studies have investigated early and long-term neurodevelopmental outcomes in children with asymptomatic cCMV (acCMV), and the data is contradictory. In the present study, we did investigate the effect of cCMV asymptomatic infection on neurological outcomes and in cognitive, language and motor development at 6 months of age. Methods Fifty-six children with cCMV asymptomatic infection were followed for 6 months, as part of a long-term surveillance program, examining their neurological and developmental outcomes. Neurological examination and Bayley-III Scales were performed. Results Clinical evaluation revealed that early neurological outcomes were essentially normal, with minor neurological deficits (i.e., tone abnormalities) in a subgroup of patients. Bayley-III scores were substantially in the normal range, with 14% showing a score less than 85 (-1SD) in the Motor Scale. Children's neurological and neurodevelopmental outcomes at 6 months of age did not differ according to the trimester of infection. Conclusions Some infants with cCMV asymptomatic infection may present minor neurological abnormalities in early stages of life. It seems useful to monitor this population for early and late neurodevelopmental sequelae.
abstract_unstemmed	Abstract Background Approximately 85–90% of congenital cytomegalovirus infections (cCMV) are asymptomatic. Few studies have investigated early and long-term neurodevelopmental outcomes in children with asymptomatic cCMV (acCMV), and the data is contradictory. In the present study, we did investigate the effect of cCMV asymptomatic infection on neurological outcomes and in cognitive, language and motor development at 6 months of age. Methods Fifty-six children with cCMV asymptomatic infection were followed for 6 months, as part of a long-term surveillance program, examining their neurological and developmental outcomes. Neurological examination and Bayley-III Scales were performed. Results Clinical evaluation revealed that early neurological outcomes were essentially normal, with minor neurological deficits (i.e., tone abnormalities) in a subgroup of patients. Bayley-III scores were substantially in the normal range, with 14% showing a score less than 85 (-1SD) in the Motor Scale. Children's neurological and neurodevelopmental outcomes at 6 months of age did not differ according to the trimester of infection. Conclusions Some infants with cCMV asymptomatic infection may present minor neurological abnormalities in early stages of life. It seems useful to monitor this population for early and late neurodevelopmental sequelae.
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title_short	Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection
url	https://doi.org/10.1186/s13052-022-01387-3 https://doaj.org/article/eab5ee8da61449a598dbaa8613641730 https://doaj.org/toc/1824-7288
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author2	Fabio Natale Anna Di Norcia Arianna Boiani Sara Temofonte Francesca Calandriello Cristina Zitarelli Barbara Caravale
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Children's neurological and neurodevelopmental outcomes at 6 months of age did not differ according to the trimester of infection. Conclusions Some infants with cCMV asymptomatic infection may present minor neurological abnormalities in early stages of life. 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Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection

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