Transcriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives

Heart failure with preserved ejection fraction (HFpEF) is increasing in incidence and has a higher prevalence compared with heart failure with reduced ejection fraction. So far, no effective treatment of HFpEF is available, due to its complex underlying pathophysiology and clinical heterogeneity. Th...
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Gespeichert in:

Autor*in:	Sebastian Rosch [verfasserIn] Karl-Philipp Rommel [verfasserIn] Markus Scholz [verfasserIn] Holger Thiele [verfasserIn] Philipp Lurz [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Übergeordnetes Werk:	In: Cardiac Failure Review - Radcliffe Medical Media, 2020, 6(2020), Seite -
Übergeordnetes Werk:	volume:6 ; year:2020 ; pages:-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.15420/cfr.2019.19

Katalog-ID:	DOAJ00084151X

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callnumber-first	R - Medicine
author	Sebastian Rosch
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topic_title	RC666-701 Transcriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives
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title	Transcriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives
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title_sort	transcriptomic research in heart failure with preserved ejection fraction: current state and future perspectives
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title_auth	Transcriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives
abstract	Heart failure with preserved ejection fraction (HFpEF) is increasing in incidence and has a higher prevalence compared with heart failure with reduced ejection fraction. So far, no effective treatment of HFpEF is available, due to its complex underlying pathophysiology and clinical heterogeneity. This article aims to provide an overview and a future perspective of transcriptomic biomarker research in HFpEF. Detailed characterisation of the HFpEF phenotype and its underlying molecular pathomechanisms may open new perspectives regarding early diagnosis, improved prognostication, new therapeutic targets and tailored therapies accounting for patient heterogeneity, which may improve quality of life. A combination of cross-sectional and longitudinal study designs with sufficiently large sample sizes are required to support this concept.
abstractGer	Heart failure with preserved ejection fraction (HFpEF) is increasing in incidence and has a higher prevalence compared with heart failure with reduced ejection fraction. So far, no effective treatment of HFpEF is available, due to its complex underlying pathophysiology and clinical heterogeneity. This article aims to provide an overview and a future perspective of transcriptomic biomarker research in HFpEF. Detailed characterisation of the HFpEF phenotype and its underlying molecular pathomechanisms may open new perspectives regarding early diagnosis, improved prognostication, new therapeutic targets and tailored therapies accounting for patient heterogeneity, which may improve quality of life. A combination of cross-sectional and longitudinal study designs with sufficiently large sample sizes are required to support this concept.
abstract_unstemmed	Heart failure with preserved ejection fraction (HFpEF) is increasing in incidence and has a higher prevalence compared with heart failure with reduced ejection fraction. So far, no effective treatment of HFpEF is available, due to its complex underlying pathophysiology and clinical heterogeneity. This article aims to provide an overview and a future perspective of transcriptomic biomarker research in HFpEF. Detailed characterisation of the HFpEF phenotype and its underlying molecular pathomechanisms may open new perspectives regarding early diagnosis, improved prognostication, new therapeutic targets and tailored therapies accounting for patient heterogeneity, which may improve quality of life. A combination of cross-sectional and longitudinal study designs with sufficiently large sample sizes are required to support this concept.
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title_short	Transcriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives
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