Entomological determinants of malaria transmission in Kayin state, Eastern Myanmar: A 24-month longitudinal study in four villages [version 3; peer review: 2 approved]

Background: The Thailand-Myanmar borderland is an area endemic for malaria where transmission is low, seasonal and unstable. The epidemiology has been described but there is relatively few data on the entomological determinants of malaria transmission. Methods: Entomological investigations were cond...
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Autor*in:	Victor Chaumeau [verfasserIn] Bénédicte Fustec [verfasserIn] Saw Nay Hsel [verfasserIn] Céline Montazeau [verfasserIn] Saw Naw Nyo [verfasserIn] Selma Metaane [verfasserIn] Sunisa Sawasdichai [verfasserIn] Prapan Kittiphanakun [verfasserIn] Phabele Phatharakokordbun [verfasserIn] Nittipha Kwansomboon [verfasserIn] Chiara Andolina [verfasserIn] Dominique Cerqueira [verfasserIn] Theeraphap Chareonviriyaphap [verfasserIn] François H. Nosten [verfasserIn] Vincent Corbel [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Übergeordnetes Werk:	In: Wellcome Open Research - Wellcome, 2017, 3(2019)
Übergeordnetes Werk:	volume:3 ; year:2019

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.12688/wellcomeopenres.14761.3

Katalog-ID:	DOAJ000888656

Internformat


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520			\|a Background: The Thailand-Myanmar borderland is an area endemic for malaria where transmission is low, seasonal and unstable. The epidemiology has been described but there is relatively few data on the entomological determinants of malaria transmission. Methods: Entomological investigations were conducted during 24 months in four villages located in Kayin state, on the Myanmar side of the Thailand-Myanmar border. Anopheles mosquitoes were identified by morphology, and molecular assays were used in order to discriminate between closely related sibling species of malaria vectors. Plasmodium infection rate was determined using quantitative real-time PCR. Results: The diversity of Anopheles mosquitoes was very high and multiple species were identified as malaria vectors. The intensity of human-vector contact (mean human-biting rate= 369 bites/person/month) compensates for the low infection rate in naturally infected populations of malaria vectors (mean sporozoite index= 0.04 and 0.17 % for P. falciparum and P. vivax respectively), yielding intermediary level of transmission intensity (mean entomological inoculation rate= 0.13 and 0.64 infective bites/person/month for P. falciparum and P. vivax, respectively). Only 36% of the infected mosquitoes were collected indoors between 09:00 pm and 05:00 am, suggesting that mosquito bed-nets would fail to prevent most of the infective bites in the study area. Conclusion: This study provided a unique opportunity to describe the entomology of malaria in low transmission settings of Southeast Asia. Our data are important in the context of malaria elimination in the Greater Mekong Subregion.
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Indexfelder

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allfields	10.12688/wellcomeopenres.14761.3 doi (DE-627)DOAJ000888656 (DE-599)DOAJ263882d67c074a78ac58531114f6d2d8 DE-627 ger DE-627 rakwb eng Victor Chaumeau verfasserin aut Entomological determinants of malaria transmission in Kayin state, Eastern Myanmar: A 24-month longitudinal study in four villages [version 3; peer review: 2 approved] 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The Thailand-Myanmar borderland is an area endemic for malaria where transmission is low, seasonal and unstable. The epidemiology has been described but there is relatively few data on the entomological determinants of malaria transmission. Methods: Entomological investigations were conducted during 24 months in four villages located in Kayin state, on the Myanmar side of the Thailand-Myanmar border. Anopheles mosquitoes were identified by morphology, and molecular assays were used in order to discriminate between closely related sibling species of malaria vectors. Plasmodium infection rate was determined using quantitative real-time PCR. Results: The diversity of Anopheles mosquitoes was very high and multiple species were identified as malaria vectors. The intensity of human-vector contact (mean human-biting rate= 369 bites/person/month) compensates for the low infection rate in naturally infected populations of malaria vectors (mean sporozoite index= 0.04 and 0.17 % for P. falciparum and P. vivax respectively), yielding intermediary level of transmission intensity (mean entomological inoculation rate= 0.13 and 0.64 infective bites/person/month for P. falciparum and P. vivax, respectively). Only 36% of the infected mosquitoes were collected indoors between 09:00 pm and 05:00 am, suggesting that mosquito bed-nets would fail to prevent most of the infective bites in the study area. Conclusion: This study provided a unique opportunity to describe the entomology of malaria in low transmission settings of Southeast Asia. Our data are important in the context of malaria elimination in the Greater Mekong Subregion. Medicine R Science Q Bénédicte Fustec verfasserin aut Saw Nay Hsel verfasserin aut Céline Montazeau verfasserin aut Saw Naw Nyo verfasserin aut Selma Metaane verfasserin aut Sunisa Sawasdichai verfasserin aut Prapan Kittiphanakun verfasserin aut Phabele Phatharakokordbun verfasserin aut Nittipha Kwansomboon verfasserin aut Chiara Andolina verfasserin aut Dominique Cerqueira verfasserin aut Theeraphap Chareonviriyaphap verfasserin aut François H. Nosten verfasserin aut Vincent Corbel verfasserin aut In Wellcome Open Research Wellcome, 2017 3(2019) (DE-627)872620239 (DE-600)2874778-1 2398502X nnns volume:3 year:2019 https://doi.org/10.12688/wellcomeopenres.14761.3 kostenfrei https://doaj.org/article/263882d67c074a78ac58531114f6d2d8 kostenfrei https://wellcomeopenresearch.org/articles/3-109/v3 kostenfrei https://doaj.org/toc/2398-502X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2019
spelling	10.12688/wellcomeopenres.14761.3 doi (DE-627)DOAJ000888656 (DE-599)DOAJ263882d67c074a78ac58531114f6d2d8 DE-627 ger DE-627 rakwb eng Victor Chaumeau verfasserin aut Entomological determinants of malaria transmission in Kayin state, Eastern Myanmar: A 24-month longitudinal study in four villages [version 3; peer review: 2 approved] 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The Thailand-Myanmar borderland is an area endemic for malaria where transmission is low, seasonal and unstable. The epidemiology has been described but there is relatively few data on the entomological determinants of malaria transmission. Methods: Entomological investigations were conducted during 24 months in four villages located in Kayin state, on the Myanmar side of the Thailand-Myanmar border. Anopheles mosquitoes were identified by morphology, and molecular assays were used in order to discriminate between closely related sibling species of malaria vectors. Plasmodium infection rate was determined using quantitative real-time PCR. Results: The diversity of Anopheles mosquitoes was very high and multiple species were identified as malaria vectors. The intensity of human-vector contact (mean human-biting rate= 369 bites/person/month) compensates for the low infection rate in naturally infected populations of malaria vectors (mean sporozoite index= 0.04 and 0.17 % for P. falciparum and P. vivax respectively), yielding intermediary level of transmission intensity (mean entomological inoculation rate= 0.13 and 0.64 infective bites/person/month for P. falciparum and P. vivax, respectively). Only 36% of the infected mosquitoes were collected indoors between 09:00 pm and 05:00 am, suggesting that mosquito bed-nets would fail to prevent most of the infective bites in the study area. Conclusion: This study provided a unique opportunity to describe the entomology of malaria in low transmission settings of Southeast Asia. Our data are important in the context of malaria elimination in the Greater Mekong Subregion. Medicine R Science Q Bénédicte Fustec verfasserin aut Saw Nay Hsel verfasserin aut Céline Montazeau verfasserin aut Saw Naw Nyo verfasserin aut Selma Metaane verfasserin aut Sunisa Sawasdichai verfasserin aut Prapan Kittiphanakun verfasserin aut Phabele Phatharakokordbun verfasserin aut Nittipha Kwansomboon verfasserin aut Chiara Andolina verfasserin aut Dominique Cerqueira verfasserin aut Theeraphap Chareonviriyaphap verfasserin aut François H. Nosten verfasserin aut Vincent Corbel verfasserin aut In Wellcome Open Research Wellcome, 2017 3(2019) (DE-627)872620239 (DE-600)2874778-1 2398502X nnns volume:3 year:2019 https://doi.org/10.12688/wellcomeopenres.14761.3 kostenfrei https://doaj.org/article/263882d67c074a78ac58531114f6d2d8 kostenfrei https://wellcomeopenresearch.org/articles/3-109/v3 kostenfrei https://doaj.org/toc/2398-502X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2019
allfields_unstemmed	10.12688/wellcomeopenres.14761.3 doi (DE-627)DOAJ000888656 (DE-599)DOAJ263882d67c074a78ac58531114f6d2d8 DE-627 ger DE-627 rakwb eng Victor Chaumeau verfasserin aut Entomological determinants of malaria transmission in Kayin state, Eastern Myanmar: A 24-month longitudinal study in four villages [version 3; peer review: 2 approved] 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The Thailand-Myanmar borderland is an area endemic for malaria where transmission is low, seasonal and unstable. The epidemiology has been described but there is relatively few data on the entomological determinants of malaria transmission. Methods: Entomological investigations were conducted during 24 months in four villages located in Kayin state, on the Myanmar side of the Thailand-Myanmar border. Anopheles mosquitoes were identified by morphology, and molecular assays were used in order to discriminate between closely related sibling species of malaria vectors. Plasmodium infection rate was determined using quantitative real-time PCR. Results: The diversity of Anopheles mosquitoes was very high and multiple species were identified as malaria vectors. The intensity of human-vector contact (mean human-biting rate= 369 bites/person/month) compensates for the low infection rate in naturally infected populations of malaria vectors (mean sporozoite index= 0.04 and 0.17 % for P. falciparum and P. vivax respectively), yielding intermediary level of transmission intensity (mean entomological inoculation rate= 0.13 and 0.64 infective bites/person/month for P. falciparum and P. vivax, respectively). Only 36% of the infected mosquitoes were collected indoors between 09:00 pm and 05:00 am, suggesting that mosquito bed-nets would fail to prevent most of the infective bites in the study area. Conclusion: This study provided a unique opportunity to describe the entomology of malaria in low transmission settings of Southeast Asia. Our data are important in the context of malaria elimination in the Greater Mekong Subregion. Medicine R Science Q Bénédicte Fustec verfasserin aut Saw Nay Hsel verfasserin aut Céline Montazeau verfasserin aut Saw Naw Nyo verfasserin aut Selma Metaane verfasserin aut Sunisa Sawasdichai verfasserin aut Prapan Kittiphanakun verfasserin aut Phabele Phatharakokordbun verfasserin aut Nittipha Kwansomboon verfasserin aut Chiara Andolina verfasserin aut Dominique Cerqueira verfasserin aut Theeraphap Chareonviriyaphap verfasserin aut François H. Nosten verfasserin aut Vincent Corbel verfasserin aut In Wellcome Open Research Wellcome, 2017 3(2019) (DE-627)872620239 (DE-600)2874778-1 2398502X nnns volume:3 year:2019 https://doi.org/10.12688/wellcomeopenres.14761.3 kostenfrei https://doaj.org/article/263882d67c074a78ac58531114f6d2d8 kostenfrei https://wellcomeopenresearch.org/articles/3-109/v3 kostenfrei https://doaj.org/toc/2398-502X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2019
allfieldsGer	10.12688/wellcomeopenres.14761.3 doi (DE-627)DOAJ000888656 (DE-599)DOAJ263882d67c074a78ac58531114f6d2d8 DE-627 ger DE-627 rakwb eng Victor Chaumeau verfasserin aut Entomological determinants of malaria transmission in Kayin state, Eastern Myanmar: A 24-month longitudinal study in four villages [version 3; peer review: 2 approved] 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The Thailand-Myanmar borderland is an area endemic for malaria where transmission is low, seasonal and unstable. The epidemiology has been described but there is relatively few data on the entomological determinants of malaria transmission. Methods: Entomological investigations were conducted during 24 months in four villages located in Kayin state, on the Myanmar side of the Thailand-Myanmar border. Anopheles mosquitoes were identified by morphology, and molecular assays were used in order to discriminate between closely related sibling species of malaria vectors. Plasmodium infection rate was determined using quantitative real-time PCR. Results: The diversity of Anopheles mosquitoes was very high and multiple species were identified as malaria vectors. The intensity of human-vector contact (mean human-biting rate= 369 bites/person/month) compensates for the low infection rate in naturally infected populations of malaria vectors (mean sporozoite index= 0.04 and 0.17 % for P. falciparum and P. vivax respectively), yielding intermediary level of transmission intensity (mean entomological inoculation rate= 0.13 and 0.64 infective bites/person/month for P. falciparum and P. vivax, respectively). Only 36% of the infected mosquitoes were collected indoors between 09:00 pm and 05:00 am, suggesting that mosquito bed-nets would fail to prevent most of the infective bites in the study area. Conclusion: This study provided a unique opportunity to describe the entomology of malaria in low transmission settings of Southeast Asia. Our data are important in the context of malaria elimination in the Greater Mekong Subregion. Medicine R Science Q Bénédicte Fustec verfasserin aut Saw Nay Hsel verfasserin aut Céline Montazeau verfasserin aut Saw Naw Nyo verfasserin aut Selma Metaane verfasserin aut Sunisa Sawasdichai verfasserin aut Prapan Kittiphanakun verfasserin aut Phabele Phatharakokordbun verfasserin aut Nittipha Kwansomboon verfasserin aut Chiara Andolina verfasserin aut Dominique Cerqueira verfasserin aut Theeraphap Chareonviriyaphap verfasserin aut François H. Nosten verfasserin aut Vincent Corbel verfasserin aut In Wellcome Open Research Wellcome, 2017 3(2019) (DE-627)872620239 (DE-600)2874778-1 2398502X nnns volume:3 year:2019 https://doi.org/10.12688/wellcomeopenres.14761.3 kostenfrei https://doaj.org/article/263882d67c074a78ac58531114f6d2d8 kostenfrei https://wellcomeopenresearch.org/articles/3-109/v3 kostenfrei https://doaj.org/toc/2398-502X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2019
allfieldsSound	10.12688/wellcomeopenres.14761.3 doi (DE-627)DOAJ000888656 (DE-599)DOAJ263882d67c074a78ac58531114f6d2d8 DE-627 ger DE-627 rakwb eng Victor Chaumeau verfasserin aut Entomological determinants of malaria transmission in Kayin state, Eastern Myanmar: A 24-month longitudinal study in four villages [version 3; peer review: 2 approved] 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The Thailand-Myanmar borderland is an area endemic for malaria where transmission is low, seasonal and unstable. The epidemiology has been described but there is relatively few data on the entomological determinants of malaria transmission. Methods: Entomological investigations were conducted during 24 months in four villages located in Kayin state, on the Myanmar side of the Thailand-Myanmar border. Anopheles mosquitoes were identified by morphology, and molecular assays were used in order to discriminate between closely related sibling species of malaria vectors. Plasmodium infection rate was determined using quantitative real-time PCR. Results: The diversity of Anopheles mosquitoes was very high and multiple species were identified as malaria vectors. The intensity of human-vector contact (mean human-biting rate= 369 bites/person/month) compensates for the low infection rate in naturally infected populations of malaria vectors (mean sporozoite index= 0.04 and 0.17 % for P. falciparum and P. vivax respectively), yielding intermediary level of transmission intensity (mean entomological inoculation rate= 0.13 and 0.64 infective bites/person/month for P. falciparum and P. vivax, respectively). Only 36% of the infected mosquitoes were collected indoors between 09:00 pm and 05:00 am, suggesting that mosquito bed-nets would fail to prevent most of the infective bites in the study area. Conclusion: This study provided a unique opportunity to describe the entomology of malaria in low transmission settings of Southeast Asia. Our data are important in the context of malaria elimination in the Greater Mekong Subregion. Medicine R Science Q Bénédicte Fustec verfasserin aut Saw Nay Hsel verfasserin aut Céline Montazeau verfasserin aut Saw Naw Nyo verfasserin aut Selma Metaane verfasserin aut Sunisa Sawasdichai verfasserin aut Prapan Kittiphanakun verfasserin aut Phabele Phatharakokordbun verfasserin aut Nittipha Kwansomboon verfasserin aut Chiara Andolina verfasserin aut Dominique Cerqueira verfasserin aut Theeraphap Chareonviriyaphap verfasserin aut François H. Nosten verfasserin aut Vincent Corbel verfasserin aut In Wellcome Open Research Wellcome, 2017 3(2019) (DE-627)872620239 (DE-600)2874778-1 2398502X nnns volume:3 year:2019 https://doi.org/10.12688/wellcomeopenres.14761.3 kostenfrei https://doaj.org/article/263882d67c074a78ac58531114f6d2d8 kostenfrei https://wellcomeopenresearch.org/articles/3-109/v3 kostenfrei https://doaj.org/toc/2398-502X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2019
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authorswithroles_txt_mv	Victor Chaumeau @@aut@@ Bénédicte Fustec @@aut@@ Saw Nay Hsel @@aut@@ Céline Montazeau @@aut@@ Saw Naw Nyo @@aut@@ Selma Metaane @@aut@@ Sunisa Sawasdichai @@aut@@ Prapan Kittiphanakun @@aut@@ Phabele Phatharakokordbun @@aut@@ Nittipha Kwansomboon @@aut@@ Chiara Andolina @@aut@@ Dominique Cerqueira @@aut@@ Theeraphap Chareonviriyaphap @@aut@@ François H. Nosten @@aut@@ Vincent Corbel @@aut@@
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author	Victor Chaumeau
spellingShingle	Victor Chaumeau misc Medicine misc R misc Science misc Q Entomological determinants of malaria transmission in Kayin state, Eastern Myanmar: A 24-month longitudinal study in four villages [version 3; peer review: 2 approved]
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topic_title	Entomological determinants of malaria transmission in Kayin state, Eastern Myanmar: A 24-month longitudinal study in four villages [version 3; peer review: 2 approved]
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title	Entomological determinants of malaria transmission in Kayin state, Eastern Myanmar: A 24-month longitudinal study in four villages [version 3; peer review: 2 approved]
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title_full	Entomological determinants of malaria transmission in Kayin state, Eastern Myanmar: A 24-month longitudinal study in four villages [version 3; peer review: 2 approved]
author_sort	Victor Chaumeau
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author_browse	Victor Chaumeau Bénédicte Fustec Saw Nay Hsel Céline Montazeau Saw Naw Nyo Selma Metaane Sunisa Sawasdichai Prapan Kittiphanakun Phabele Phatharakokordbun Nittipha Kwansomboon Chiara Andolina Dominique Cerqueira Theeraphap Chareonviriyaphap François H. Nosten Vincent Corbel
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title_sort	entomological determinants of malaria transmission in kayin state, eastern myanmar: a 24-month longitudinal study in four villages [version 3; peer review: 2 approved]
title_auth	Entomological determinants of malaria transmission in Kayin state, Eastern Myanmar: A 24-month longitudinal study in four villages [version 3; peer review: 2 approved]
abstract	Background: The Thailand-Myanmar borderland is an area endemic for malaria where transmission is low, seasonal and unstable. The epidemiology has been described but there is relatively few data on the entomological determinants of malaria transmission. Methods: Entomological investigations were conducted during 24 months in four villages located in Kayin state, on the Myanmar side of the Thailand-Myanmar border. Anopheles mosquitoes were identified by morphology, and molecular assays were used in order to discriminate between closely related sibling species of malaria vectors. Plasmodium infection rate was determined using quantitative real-time PCR. Results: The diversity of Anopheles mosquitoes was very high and multiple species were identified as malaria vectors. The intensity of human-vector contact (mean human-biting rate= 369 bites/person/month) compensates for the low infection rate in naturally infected populations of malaria vectors (mean sporozoite index= 0.04 and 0.17 % for P. falciparum and P. vivax respectively), yielding intermediary level of transmission intensity (mean entomological inoculation rate= 0.13 and 0.64 infective bites/person/month for P. falciparum and P. vivax, respectively). Only 36% of the infected mosquitoes were collected indoors between 09:00 pm and 05:00 am, suggesting that mosquito bed-nets would fail to prevent most of the infective bites in the study area. Conclusion: This study provided a unique opportunity to describe the entomology of malaria in low transmission settings of Southeast Asia. Our data are important in the context of malaria elimination in the Greater Mekong Subregion.
abstractGer	Background: The Thailand-Myanmar borderland is an area endemic for malaria where transmission is low, seasonal and unstable. The epidemiology has been described but there is relatively few data on the entomological determinants of malaria transmission. Methods: Entomological investigations were conducted during 24 months in four villages located in Kayin state, on the Myanmar side of the Thailand-Myanmar border. Anopheles mosquitoes were identified by morphology, and molecular assays were used in order to discriminate between closely related sibling species of malaria vectors. Plasmodium infection rate was determined using quantitative real-time PCR. Results: The diversity of Anopheles mosquitoes was very high and multiple species were identified as malaria vectors. The intensity of human-vector contact (mean human-biting rate= 369 bites/person/month) compensates for the low infection rate in naturally infected populations of malaria vectors (mean sporozoite index= 0.04 and 0.17 % for P. falciparum and P. vivax respectively), yielding intermediary level of transmission intensity (mean entomological inoculation rate= 0.13 and 0.64 infective bites/person/month for P. falciparum and P. vivax, respectively). Only 36% of the infected mosquitoes were collected indoors between 09:00 pm and 05:00 am, suggesting that mosquito bed-nets would fail to prevent most of the infective bites in the study area. Conclusion: This study provided a unique opportunity to describe the entomology of malaria in low transmission settings of Southeast Asia. Our data are important in the context of malaria elimination in the Greater Mekong Subregion.
abstract_unstemmed	Background: The Thailand-Myanmar borderland is an area endemic for malaria where transmission is low, seasonal and unstable. The epidemiology has been described but there is relatively few data on the entomological determinants of malaria transmission. Methods: Entomological investigations were conducted during 24 months in four villages located in Kayin state, on the Myanmar side of the Thailand-Myanmar border. Anopheles mosquitoes were identified by morphology, and molecular assays were used in order to discriminate between closely related sibling species of malaria vectors. Plasmodium infection rate was determined using quantitative real-time PCR. Results: The diversity of Anopheles mosquitoes was very high and multiple species were identified as malaria vectors. The intensity of human-vector contact (mean human-biting rate= 369 bites/person/month) compensates for the low infection rate in naturally infected populations of malaria vectors (mean sporozoite index= 0.04 and 0.17 % for P. falciparum and P. vivax respectively), yielding intermediary level of transmission intensity (mean entomological inoculation rate= 0.13 and 0.64 infective bites/person/month for P. falciparum and P. vivax, respectively). Only 36% of the infected mosquitoes were collected indoors between 09:00 pm and 05:00 am, suggesting that mosquito bed-nets would fail to prevent most of the infective bites in the study area. Conclusion: This study provided a unique opportunity to describe the entomology of malaria in low transmission settings of Southeast Asia. Our data are important in the context of malaria elimination in the Greater Mekong Subregion.
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title_short	Entomological determinants of malaria transmission in Kayin state, Eastern Myanmar: A 24-month longitudinal study in four villages [version 3; peer review: 2 approved]
url	https://doi.org/10.12688/wellcomeopenres.14761.3 https://doaj.org/article/263882d67c074a78ac58531114f6d2d8 https://wellcomeopenresearch.org/articles/3-109/v3 https://doaj.org/toc/2398-502X
remote_bool	true
author2	Bénédicte Fustec Saw Nay Hsel Céline Montazeau Saw Naw Nyo Selma Metaane Sunisa Sawasdichai Prapan Kittiphanakun Phabele Phatharakokordbun Nittipha Kwansomboon Chiara Andolina Dominique Cerqueira Theeraphap Chareonviriyaphap François H. Nosten Vincent Corbel
author2Str	Bénédicte Fustec Saw Nay Hsel Céline Montazeau Saw Naw Nyo Selma Metaane Sunisa Sawasdichai Prapan Kittiphanakun Phabele Phatharakokordbun Nittipha Kwansomboon Chiara Andolina Dominique Cerqueira Theeraphap Chareonviriyaphap François H. Nosten Vincent Corbel
ppnlink	872620239
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hochschulschrift_bool	false
doi_str	10.12688/wellcomeopenres.14761.3
up_date	2024-07-03T17:07:25.972Z
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Entomological determinants of malaria transmission in Kayin state, Eastern Myanmar: A 24-month longitudinal study in four villages [version 3; peer review: 2 approved]

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