Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancer

RNA binding proteins (RBPs) can participate in regulatory networks to control alternative splicing. Here the authors show that DAP3 functions as an RBP splicing modulator via two mechanisms, and that its overexpression leads to mis-splicing events in cancers.

Gespeichert in:

Autor*in:	Jian Han [verfasserIn] Omer An [verfasserIn] Xi Ren [verfasserIn] Yangyang Song [verfasserIn] Sze Jing Tang [verfasserIn] Haoqing Shen [verfasserIn] Xinyu Ke [verfasserIn] Vanessa Hui En Ng [verfasserIn] Daryl Jin Tai Tay [verfasserIn] Hui Qing Tan [verfasserIn] Dennis Kappei [verfasserIn] Henry Yang [verfasserIn] Leilei Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 13(2022), 1, Seite 16
Übergeordnetes Werk:	volume:13 ; year:2022 ; number:1 ; pages:16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-022-29400-7

Katalog-ID:	DOAJ000915416

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author	Jian Han
spellingShingle	Jian Han misc Science misc Q Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancer
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topic_title	Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancer
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title	Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancer
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title_full	Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancer
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author_browse	Jian Han Omer An Xi Ren Yangyang Song Sze Jing Tang Haoqing Shen Xinyu Ke Vanessa Hui En Ng Daryl Jin Tai Tay Hui Qing Tan Dennis Kappei Henry Yang Leilei Chen
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title_sort	multilayered control of splicing regulatory networks by dap3 leads to widespread alternative splicing changes in cancer
title_auth	Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancer
abstract	RNA binding proteins (RBPs) can participate in regulatory networks to control alternative splicing. Here the authors show that DAP3 functions as an RBP splicing modulator via two mechanisms, and that its overexpression leads to mis-splicing events in cancers.
abstractGer	RNA binding proteins (RBPs) can participate in regulatory networks to control alternative splicing. Here the authors show that DAP3 functions as an RBP splicing modulator via two mechanisms, and that its overexpression leads to mis-splicing events in cancers.
abstract_unstemmed	RNA binding proteins (RBPs) can participate in regulatory networks to control alternative splicing. Here the authors show that DAP3 functions as an RBP splicing modulator via two mechanisms, and that its overexpression leads to mis-splicing events in cancers.
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title_short	Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancer
url	https://doi.org/10.1038/s41467-022-29400-7 https://doaj.org/article/6eb43cb851ca43dcb45c66112bff8c52 https://doaj.org/toc/2041-1723
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Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancer

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