Mesial temporal tau in amyloid-β-negative cognitively normal older persons

Abstract Background Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ−) occurs with aging. The tau PET tracer 18F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the...
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Autor*in:	Natasha Krishnadas [verfasserIn] Vincent Doré [verfasserIn] Colin Groot [verfasserIn] Fiona Lamb [verfasserIn] Pierrick Bourgeat [verfasserIn] Samantha C. Burnham [verfasserIn] Kun Huang [verfasserIn] Anita M. Y. Goh [verfasserIn] Colin L. Masters [verfasserIn] Victor L. Villemagne [verfasserIn] Christopher C. Rowe [verfasserIn] for the AIBL research group [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Positron emission tomography (PET) Cognition Aging 18F-MK6240 Mesial temporal lobe Tau

Übergeordnetes Werk:	In: Alzheimer’s Research & Therapy - BMC, 2015, 14(2022), 1, Seite 10
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:1 ; pages:10

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s13195-022-00993-x

Katalog-ID:	DOAJ00091620X

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520			\|a Abstract Background Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ−) occurs with aging. The tau PET tracer 18F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ− cognitively unimpaired (CU) individuals. Methods One hundred and ninety-nine Aβ− participants (Centiloid < 25) who were CU underwent 18F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuous variables and compared between high and low MTL SUVR groups. Results In this cohort with a stable clinical classification of CU for a mean of 5.3 years prior to and at the time of tau PET, MTL tau was visually observed in 9% of the participants and was limited to Braak stages I–II. MTL tau was correlated with age (r = 0.24, p < 0.001). Age contributed to the variance in cognitive scores but MTL tau did not. MTL tau was not greater with subjective memory complaint, nor was there a correlation between MTL tau and Aβ Centiloid value, but high tau was associated with smaller HV. Participants with MTL tau had higher tau SUVR in the neocortex but this was driven by the cerebellar reference region and was not present when using white matter normalization. Conclusions In an Aβ− CU cohort, tau tracer binding in the mesial temporal lobe was age-related and associated with smaller hippocampi, but not with subjective or objective cognitive impairment.
650		4	\|a Positron emission tomography (PET)
650		4	\|a Cognition
650		4	\|a Aging
650		4	\|a 18F-MK6240
650		4	\|a Mesial temporal lobe
650		4	\|a Tau
653		0	\|a Neurosciences. Biological psychiatry. Neuropsychiatry
653		0	\|a Neurology. Diseases of the nervous system
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allfields	10.1186/s13195-022-00993-x doi (DE-627)DOAJ00091620X (DE-599)DOAJ29865099cabe401bb295621f4d6488e7 DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 Natasha Krishnadas verfasserin aut Mesial temporal tau in amyloid-β-negative cognitively normal older persons 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ−) occurs with aging. The tau PET tracer 18F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ− cognitively unimpaired (CU) individuals. Methods One hundred and ninety-nine Aβ− participants (Centiloid < 25) who were CU underwent 18F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuous variables and compared between high and low MTL SUVR groups. Results In this cohort with a stable clinical classification of CU for a mean of 5.3 years prior to and at the time of tau PET, MTL tau was visually observed in 9% of the participants and was limited to Braak stages I–II. MTL tau was correlated with age (r = 0.24, p < 0.001). Age contributed to the variance in cognitive scores but MTL tau did not. MTL tau was not greater with subjective memory complaint, nor was there a correlation between MTL tau and Aβ Centiloid value, but high tau was associated with smaller HV. Participants with MTL tau had higher tau SUVR in the neocortex but this was driven by the cerebellar reference region and was not present when using white matter normalization. Conclusions In an Aβ− CU cohort, tau tracer binding in the mesial temporal lobe was age-related and associated with smaller hippocampi, but not with subjective or objective cognitive impairment. Positron emission tomography (PET) Cognition Aging 18F-MK6240 Mesial temporal lobe Tau Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Vincent Doré verfasserin aut Colin Groot verfasserin aut Fiona Lamb verfasserin aut Pierrick Bourgeat verfasserin aut Samantha C. Burnham verfasserin aut Kun Huang verfasserin aut Anita M. Y. Goh verfasserin aut Colin L. Masters verfasserin aut Victor L. Villemagne verfasserin aut Christopher C. Rowe verfasserin aut for the AIBL research group verfasserin aut In Alzheimer’s Research & Therapy BMC, 2015 14(2022), 1, Seite 10 (DE-627)605683557 (DE-600)2506521-X 17589193 nnns volume:14 year:2022 number:1 pages:10 https://doi.org/10.1186/s13195-022-00993-x kostenfrei https://doaj.org/article/29865099cabe401bb295621f4d6488e7 kostenfrei https://doi.org/10.1186/s13195-022-00993-x kostenfrei https://doaj.org/toc/1758-9193 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1 10
spelling	10.1186/s13195-022-00993-x doi (DE-627)DOAJ00091620X (DE-599)DOAJ29865099cabe401bb295621f4d6488e7 DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 Natasha Krishnadas verfasserin aut Mesial temporal tau in amyloid-β-negative cognitively normal older persons 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ−) occurs with aging. The tau PET tracer 18F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ− cognitively unimpaired (CU) individuals. Methods One hundred and ninety-nine Aβ− participants (Centiloid < 25) who were CU underwent 18F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuous variables and compared between high and low MTL SUVR groups. Results In this cohort with a stable clinical classification of CU for a mean of 5.3 years prior to and at the time of tau PET, MTL tau was visually observed in 9% of the participants and was limited to Braak stages I–II. MTL tau was correlated with age (r = 0.24, p < 0.001). Age contributed to the variance in cognitive scores but MTL tau did not. MTL tau was not greater with subjective memory complaint, nor was there a correlation between MTL tau and Aβ Centiloid value, but high tau was associated with smaller HV. Participants with MTL tau had higher tau SUVR in the neocortex but this was driven by the cerebellar reference region and was not present when using white matter normalization. Conclusions In an Aβ− CU cohort, tau tracer binding in the mesial temporal lobe was age-related and associated with smaller hippocampi, but not with subjective or objective cognitive impairment. Positron emission tomography (PET) Cognition Aging 18F-MK6240 Mesial temporal lobe Tau Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Vincent Doré verfasserin aut Colin Groot verfasserin aut Fiona Lamb verfasserin aut Pierrick Bourgeat verfasserin aut Samantha C. Burnham verfasserin aut Kun Huang verfasserin aut Anita M. Y. Goh verfasserin aut Colin L. Masters verfasserin aut Victor L. Villemagne verfasserin aut Christopher C. Rowe verfasserin aut for the AIBL research group verfasserin aut In Alzheimer’s Research & Therapy BMC, 2015 14(2022), 1, Seite 10 (DE-627)605683557 (DE-600)2506521-X 17589193 nnns volume:14 year:2022 number:1 pages:10 https://doi.org/10.1186/s13195-022-00993-x kostenfrei https://doaj.org/article/29865099cabe401bb295621f4d6488e7 kostenfrei https://doi.org/10.1186/s13195-022-00993-x kostenfrei https://doaj.org/toc/1758-9193 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1 10
allfields_unstemmed	10.1186/s13195-022-00993-x doi (DE-627)DOAJ00091620X (DE-599)DOAJ29865099cabe401bb295621f4d6488e7 DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 Natasha Krishnadas verfasserin aut Mesial temporal tau in amyloid-β-negative cognitively normal older persons 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ−) occurs with aging. The tau PET tracer 18F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ− cognitively unimpaired (CU) individuals. Methods One hundred and ninety-nine Aβ− participants (Centiloid < 25) who were CU underwent 18F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuous variables and compared between high and low MTL SUVR groups. Results In this cohort with a stable clinical classification of CU for a mean of 5.3 years prior to and at the time of tau PET, MTL tau was visually observed in 9% of the participants and was limited to Braak stages I–II. MTL tau was correlated with age (r = 0.24, p < 0.001). Age contributed to the variance in cognitive scores but MTL tau did not. MTL tau was not greater with subjective memory complaint, nor was there a correlation between MTL tau and Aβ Centiloid value, but high tau was associated with smaller HV. Participants with MTL tau had higher tau SUVR in the neocortex but this was driven by the cerebellar reference region and was not present when using white matter normalization. Conclusions In an Aβ− CU cohort, tau tracer binding in the mesial temporal lobe was age-related and associated with smaller hippocampi, but not with subjective or objective cognitive impairment. Positron emission tomography (PET) Cognition Aging 18F-MK6240 Mesial temporal lobe Tau Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Vincent Doré verfasserin aut Colin Groot verfasserin aut Fiona Lamb verfasserin aut Pierrick Bourgeat verfasserin aut Samantha C. Burnham verfasserin aut Kun Huang verfasserin aut Anita M. Y. Goh verfasserin aut Colin L. Masters verfasserin aut Victor L. Villemagne verfasserin aut Christopher C. Rowe verfasserin aut for the AIBL research group verfasserin aut In Alzheimer’s Research & Therapy BMC, 2015 14(2022), 1, Seite 10 (DE-627)605683557 (DE-600)2506521-X 17589193 nnns volume:14 year:2022 number:1 pages:10 https://doi.org/10.1186/s13195-022-00993-x kostenfrei https://doaj.org/article/29865099cabe401bb295621f4d6488e7 kostenfrei https://doi.org/10.1186/s13195-022-00993-x kostenfrei https://doaj.org/toc/1758-9193 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1 10
allfieldsGer	10.1186/s13195-022-00993-x doi (DE-627)DOAJ00091620X (DE-599)DOAJ29865099cabe401bb295621f4d6488e7 DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 Natasha Krishnadas verfasserin aut Mesial temporal tau in amyloid-β-negative cognitively normal older persons 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ−) occurs with aging. The tau PET tracer 18F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ− cognitively unimpaired (CU) individuals. Methods One hundred and ninety-nine Aβ− participants (Centiloid < 25) who were CU underwent 18F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuous variables and compared between high and low MTL SUVR groups. Results In this cohort with a stable clinical classification of CU for a mean of 5.3 years prior to and at the time of tau PET, MTL tau was visually observed in 9% of the participants and was limited to Braak stages I–II. MTL tau was correlated with age (r = 0.24, p < 0.001). Age contributed to the variance in cognitive scores but MTL tau did not. MTL tau was not greater with subjective memory complaint, nor was there a correlation between MTL tau and Aβ Centiloid value, but high tau was associated with smaller HV. Participants with MTL tau had higher tau SUVR in the neocortex but this was driven by the cerebellar reference region and was not present when using white matter normalization. Conclusions In an Aβ− CU cohort, tau tracer binding in the mesial temporal lobe was age-related and associated with smaller hippocampi, but not with subjective or objective cognitive impairment. Positron emission tomography (PET) Cognition Aging 18F-MK6240 Mesial temporal lobe Tau Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Vincent Doré verfasserin aut Colin Groot verfasserin aut Fiona Lamb verfasserin aut Pierrick Bourgeat verfasserin aut Samantha C. Burnham verfasserin aut Kun Huang verfasserin aut Anita M. Y. Goh verfasserin aut Colin L. Masters verfasserin aut Victor L. Villemagne verfasserin aut Christopher C. Rowe verfasserin aut for the AIBL research group verfasserin aut In Alzheimer’s Research & Therapy BMC, 2015 14(2022), 1, Seite 10 (DE-627)605683557 (DE-600)2506521-X 17589193 nnns volume:14 year:2022 number:1 pages:10 https://doi.org/10.1186/s13195-022-00993-x kostenfrei https://doaj.org/article/29865099cabe401bb295621f4d6488e7 kostenfrei https://doi.org/10.1186/s13195-022-00993-x kostenfrei https://doaj.org/toc/1758-9193 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1 10
allfieldsSound	10.1186/s13195-022-00993-x doi (DE-627)DOAJ00091620X (DE-599)DOAJ29865099cabe401bb295621f4d6488e7 DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 Natasha Krishnadas verfasserin aut Mesial temporal tau in amyloid-β-negative cognitively normal older persons 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ−) occurs with aging. The tau PET tracer 18F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ− cognitively unimpaired (CU) individuals. Methods One hundred and ninety-nine Aβ− participants (Centiloid < 25) who were CU underwent 18F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuous variables and compared between high and low MTL SUVR groups. Results In this cohort with a stable clinical classification of CU for a mean of 5.3 years prior to and at the time of tau PET, MTL tau was visually observed in 9% of the participants and was limited to Braak stages I–II. MTL tau was correlated with age (r = 0.24, p < 0.001). Age contributed to the variance in cognitive scores but MTL tau did not. MTL tau was not greater with subjective memory complaint, nor was there a correlation between MTL tau and Aβ Centiloid value, but high tau was associated with smaller HV. Participants with MTL tau had higher tau SUVR in the neocortex but this was driven by the cerebellar reference region and was not present when using white matter normalization. Conclusions In an Aβ− CU cohort, tau tracer binding in the mesial temporal lobe was age-related and associated with smaller hippocampi, but not with subjective or objective cognitive impairment. Positron emission tomography (PET) Cognition Aging 18F-MK6240 Mesial temporal lobe Tau Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Vincent Doré verfasserin aut Colin Groot verfasserin aut Fiona Lamb verfasserin aut Pierrick Bourgeat verfasserin aut Samantha C. Burnham verfasserin aut Kun Huang verfasserin aut Anita M. Y. Goh verfasserin aut Colin L. Masters verfasserin aut Victor L. Villemagne verfasserin aut Christopher C. Rowe verfasserin aut for the AIBL research group verfasserin aut In Alzheimer’s Research & Therapy BMC, 2015 14(2022), 1, Seite 10 (DE-627)605683557 (DE-600)2506521-X 17589193 nnns volume:14 year:2022 number:1 pages:10 https://doi.org/10.1186/s13195-022-00993-x kostenfrei https://doaj.org/article/29865099cabe401bb295621f4d6488e7 kostenfrei https://doi.org/10.1186/s13195-022-00993-x kostenfrei https://doaj.org/toc/1758-9193 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1 10
language	English
source	In Alzheimer’s Research & Therapy 14(2022), 1, Seite 10 volume:14 year:2022 number:1 pages:10
sourceStr	In Alzheimer’s Research & Therapy 14(2022), 1, Seite 10 volume:14 year:2022 number:1 pages:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Positron emission tomography (PET) Cognition Aging 18F-MK6240 Mesial temporal lobe Tau Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system
isfreeaccess_bool	true
container_title	Alzheimer’s Research & Therapy
authorswithroles_txt_mv	Natasha Krishnadas @@aut@@ Vincent Doré @@aut@@ Colin Groot @@aut@@ Fiona Lamb @@aut@@ Pierrick Bourgeat @@aut@@ Samantha C. Burnham @@aut@@ Kun Huang @@aut@@ Anita M. Y. Goh @@aut@@ Colin L. Masters @@aut@@ Victor L. Villemagne @@aut@@ Christopher C. Rowe @@aut@@ for the AIBL research group @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	605683557
id	DOAJ00091620X
language_de	englisch
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The tau PET tracer 18F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ− cognitively unimpaired (CU) individuals. Methods One hundred and ninety-nine Aβ− participants (Centiloid < 25) who were CU underwent 18F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuous variables and compared between high and low MTL SUVR groups. Results In this cohort with a stable clinical classification of CU for a mean of 5.3 years prior to and at the time of tau PET, MTL tau was visually observed in 9% of the participants and was limited to Braak stages I–II. MTL tau was correlated with age (r = 0.24, p < 0.001). 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callnumber-first	R - Medicine
author	Natasha Krishnadas
spellingShingle	Natasha Krishnadas misc RC321-571 misc RC346-429 misc Positron emission tomography (PET) misc Cognition misc Aging misc 18F-MK6240 misc Mesial temporal lobe misc Tau misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Neurology. Diseases of the nervous system Mesial temporal tau in amyloid-β-negative cognitively normal older persons
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topic_title	RC321-571 RC346-429 Mesial temporal tau in amyloid-β-negative cognitively normal older persons Positron emission tomography (PET) Cognition Aging 18F-MK6240 Mesial temporal lobe Tau
topic	misc RC321-571 misc RC346-429 misc Positron emission tomography (PET) misc Cognition misc Aging misc 18F-MK6240 misc Mesial temporal lobe misc Tau misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RC321-571 misc RC346-429 misc Positron emission tomography (PET) misc Cognition misc Aging misc 18F-MK6240 misc Mesial temporal lobe misc Tau misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Neurology. Diseases of the nervous system
topic_browse	misc RC321-571 misc RC346-429 misc Positron emission tomography (PET) misc Cognition misc Aging misc 18F-MK6240 misc Mesial temporal lobe misc Tau misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Neurology. Diseases of the nervous system
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title	Mesial temporal tau in amyloid-β-negative cognitively normal older persons
ctrlnum	(DE-627)DOAJ00091620X (DE-599)DOAJ29865099cabe401bb295621f4d6488e7
title_full	Mesial temporal tau in amyloid-β-negative cognitively normal older persons
author_sort	Natasha Krishnadas
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author_browse	Natasha Krishnadas Vincent Doré Colin Groot Fiona Lamb Pierrick Bourgeat Samantha C. Burnham Kun Huang Anita M. Y. Goh Colin L. Masters Victor L. Villemagne Christopher C. Rowe for the AIBL research group
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title_sort	mesial temporal tau in amyloid-β-negative cognitively normal older persons
callnumber	RC321-571
title_auth	Mesial temporal tau in amyloid-β-negative cognitively normal older persons
abstract	Abstract Background Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ−) occurs with aging. The tau PET tracer 18F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ− cognitively unimpaired (CU) individuals. Methods One hundred and ninety-nine Aβ− participants (Centiloid < 25) who were CU underwent 18F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuous variables and compared between high and low MTL SUVR groups. Results In this cohort with a stable clinical classification of CU for a mean of 5.3 years prior to and at the time of tau PET, MTL tau was visually observed in 9% of the participants and was limited to Braak stages I–II. MTL tau was correlated with age (r = 0.24, p < 0.001). Age contributed to the variance in cognitive scores but MTL tau did not. MTL tau was not greater with subjective memory complaint, nor was there a correlation between MTL tau and Aβ Centiloid value, but high tau was associated with smaller HV. Participants with MTL tau had higher tau SUVR in the neocortex but this was driven by the cerebellar reference region and was not present when using white matter normalization. Conclusions In an Aβ− CU cohort, tau tracer binding in the mesial temporal lobe was age-related and associated with smaller hippocampi, but not with subjective or objective cognitive impairment.
abstractGer	Abstract Background Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ−) occurs with aging. The tau PET tracer 18F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ− cognitively unimpaired (CU) individuals. Methods One hundred and ninety-nine Aβ− participants (Centiloid < 25) who were CU underwent 18F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuous variables and compared between high and low MTL SUVR groups. Results In this cohort with a stable clinical classification of CU for a mean of 5.3 years prior to and at the time of tau PET, MTL tau was visually observed in 9% of the participants and was limited to Braak stages I–II. MTL tau was correlated with age (r = 0.24, p < 0.001). Age contributed to the variance in cognitive scores but MTL tau did not. MTL tau was not greater with subjective memory complaint, nor was there a correlation between MTL tau and Aβ Centiloid value, but high tau was associated with smaller HV. Participants with MTL tau had higher tau SUVR in the neocortex but this was driven by the cerebellar reference region and was not present when using white matter normalization. Conclusions In an Aβ− CU cohort, tau tracer binding in the mesial temporal lobe was age-related and associated with smaller hippocampi, but not with subjective or objective cognitive impairment.
abstract_unstemmed	Abstract Background Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ−) occurs with aging. The tau PET tracer 18F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ− cognitively unimpaired (CU) individuals. Methods One hundred and ninety-nine Aβ− participants (Centiloid < 25) who were CU underwent 18F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuous variables and compared between high and low MTL SUVR groups. Results In this cohort with a stable clinical classification of CU for a mean of 5.3 years prior to and at the time of tau PET, MTL tau was visually observed in 9% of the participants and was limited to Braak stages I–II. MTL tau was correlated with age (r = 0.24, p < 0.001). Age contributed to the variance in cognitive scores but MTL tau did not. MTL tau was not greater with subjective memory complaint, nor was there a correlation between MTL tau and Aβ Centiloid value, but high tau was associated with smaller HV. Participants with MTL tau had higher tau SUVR in the neocortex but this was driven by the cerebellar reference region and was not present when using white matter normalization. Conclusions In an Aβ− CU cohort, tau tracer binding in the mesial temporal lobe was age-related and associated with smaller hippocampi, but not with subjective or objective cognitive impairment.
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title_short	Mesial temporal tau in amyloid-β-negative cognitively normal older persons
url	https://doi.org/10.1186/s13195-022-00993-x https://doaj.org/article/29865099cabe401bb295621f4d6488e7 https://doaj.org/toc/1758-9193
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author2	Vincent Doré Colin Groot Fiona Lamb Pierrick Bourgeat Samantha C. Burnham Kun Huang Anita M. Y. Goh Colin L. Masters Victor L. Villemagne Christopher C. Rowe for the AIBL research group
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Mesial temporal tau in amyloid-β-negative cognitively normal older persons

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