Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment?

Pancreatic Ductal Adenocarcinoma (PDAC) constitutes a leading cause of cancer death globally. Its mortality remains unaltered despite the considerable scientific progress made in the fields of diagnostics and treatment. Exosomes comprise of small extracellular vesicles secreted by nearly all cells;...
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Autor*in:	Stavros P. Papadakos [verfasserIn] Nikolaos Dedes [verfasserIn] Alexandros Pergaris [verfasserIn] Maria Gazouli [verfasserIn] Stamatios Theocharis [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	pancreatic cancer exosomes biomarkers diagnosis prognosis therapy

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 7, p 3620
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:7, p 3620

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms23073620

Katalog-ID:	DOAJ000936839

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language	English
source	In International Journal of Molecular Sciences 23(2022), 7, p 3620 volume:23 year:2022 number:7, p 3620
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callnumber-first	Q - Science
author	Stavros P. Papadakos
spellingShingle	Stavros P. Papadakos misc QH301-705.5 misc QD1-999 misc pancreatic cancer misc exosomes misc biomarkers misc diagnosis misc prognosis misc therapy misc Biology (General) misc Chemistry Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment?
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topic_title	QH301-705.5 QD1-999 Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment? pancreatic cancer exosomes biomarkers diagnosis prognosis therapy
topic	misc QH301-705.5 misc QD1-999 misc pancreatic cancer misc exosomes misc biomarkers misc diagnosis misc prognosis misc therapy misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc pancreatic cancer misc exosomes misc biomarkers misc diagnosis misc prognosis misc therapy misc Biology (General) misc Chemistry
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title	Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment?
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title_full	Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment?
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title_sort	exosomes in the treatment of pancreatic cancer: a moonshot to pdac treatment?
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title_auth	Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment?
abstract	Pancreatic Ductal Adenocarcinoma (PDAC) constitutes a leading cause of cancer death globally. Its mortality remains unaltered despite the considerable scientific progress made in the fields of diagnostics and treatment. Exosomes comprise of small extracellular vesicles secreted by nearly all cells; their cargo contains a vast array of biomolecules, such as proteins and microRNAs. It is currently established that their role as messengers is central to a plethora of both physiologic and pathologic processes. Accumulating data have shed light on their contributions to carcinogenesis, metastasis, and immunological response. Meanwhile, the advancement of personalized targeted therapies into everyday clinical practice necessitates the development of cost-efficient treatment approaches. The role of exosomes is currently being extensively investigated towards this direction. This review aims to summarize the current pre-clinical and clinical evidence regarding the effects of exosomal applications in the timely diagnosis, prognosis, and therapeutic management of pancreatic cancer.
abstractGer	Pancreatic Ductal Adenocarcinoma (PDAC) constitutes a leading cause of cancer death globally. Its mortality remains unaltered despite the considerable scientific progress made in the fields of diagnostics and treatment. Exosomes comprise of small extracellular vesicles secreted by nearly all cells; their cargo contains a vast array of biomolecules, such as proteins and microRNAs. It is currently established that their role as messengers is central to a plethora of both physiologic and pathologic processes. Accumulating data have shed light on their contributions to carcinogenesis, metastasis, and immunological response. Meanwhile, the advancement of personalized targeted therapies into everyday clinical practice necessitates the development of cost-efficient treatment approaches. The role of exosomes is currently being extensively investigated towards this direction. This review aims to summarize the current pre-clinical and clinical evidence regarding the effects of exosomal applications in the timely diagnosis, prognosis, and therapeutic management of pancreatic cancer.
abstract_unstemmed	Pancreatic Ductal Adenocarcinoma (PDAC) constitutes a leading cause of cancer death globally. Its mortality remains unaltered despite the considerable scientific progress made in the fields of diagnostics and treatment. Exosomes comprise of small extracellular vesicles secreted by nearly all cells; their cargo contains a vast array of biomolecules, such as proteins and microRNAs. It is currently established that their role as messengers is central to a plethora of both physiologic and pathologic processes. Accumulating data have shed light on their contributions to carcinogenesis, metastasis, and immunological response. Meanwhile, the advancement of personalized targeted therapies into everyday clinical practice necessitates the development of cost-efficient treatment approaches. The role of exosomes is currently being extensively investigated towards this direction. This review aims to summarize the current pre-clinical and clinical evidence regarding the effects of exosomal applications in the timely diagnosis, prognosis, and therapeutic management of pancreatic cancer.
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container_issue	7, p 3620
title_short	Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment?
url	https://doi.org/10.3390/ijms23073620 https://doaj.org/article/070a2be0578b48de825656f5840edfcc https://www.mdpi.com/1422-0067/23/7/3620 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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