Insights Into Translatomics in the Nervous System

Most neurological disorders are caused by abnormal gene translation. Generally, dysregulation of elements involved in the translational process disrupts homeostasis in neurons and neuroglia. Better understanding of how the gene translation process occurs requires detailed analysis of transcriptomic...
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Gespeichert in:

Autor*in:	Shuxia Zhang [verfasserIn] Yeru Chen [verfasserIn] Yongjie Wang [verfasserIn] Piao Zhang [verfasserIn] Gang Chen [verfasserIn] Youfa Zhou [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	translatomics RNC-mRNA the nervous system polysome profiling ribosome profiling translating ribosome affinity purification

Übergeordnetes Werk:	In: Frontiers in Genetics - Frontiers Media S.A., 2011, 11(2020)
Übergeordnetes Werk:	volume:11 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fgene.2020.599548

Katalog-ID:	DOAJ000938998

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allfieldsSound	10.3389/fgene.2020.599548 doi (DE-627)DOAJ000938998 (DE-599)DOAJd41731179d274667954efc082c2e92e8 DE-627 ger DE-627 rakwb eng QH426-470 Shuxia Zhang verfasserin aut Insights Into Translatomics in the Nervous System 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Most neurological disorders are caused by abnormal gene translation. Generally, dysregulation of elements involved in the translational process disrupts homeostasis in neurons and neuroglia. Better understanding of how the gene translation process occurs requires detailed analysis of transcriptomic and proteomic profile data. However, a lack of strictly direct correlations between mRNA and protein levels limits translational investigation by combining transcriptomic and proteomic profiling. The much better correlation between proteins and translated mRNAs than total mRNAs in abundance and insufficiently sensitive proteomics approach promote the requirement of advances in translatomics technology. Translatomics which capture and sequence the mRNAs associated with ribosomes has been effective in identifying translational changes by genetics or projections, ribosome stalling, local translation, and transcript isoforms in the nervous system. Here, we place emphasis on the main three translatomics methods currently used to profile mRNAs attached to ribosome-nascent chain complex (RNC-mRNA). Their prominent applications in neurological diseases including glioma, neuropathic pain, depression, fragile X syndrome (FXS), neurodegenerative disorders are outlined. The content reviewed here expands our understanding on the contributions of aberrant translation to neurological disease development. translatomics RNC-mRNA the nervous system polysome profiling ribosome profiling translating ribosome affinity purification Genetics Yeru Chen verfasserin aut Yongjie Wang verfasserin aut Yongjie Wang verfasserin aut Piao Zhang verfasserin aut Gang Chen verfasserin aut Youfa Zhou verfasserin aut In Frontiers in Genetics Frontiers Media S.A., 2011 11(2020) (DE-627)65799829X (DE-600)2606823-0 16648021 nnns volume:11 year:2020 https://doi.org/10.3389/fgene.2020.599548 kostenfrei https://doaj.org/article/d41731179d274667954efc082c2e92e8 kostenfrei https://www.frontiersin.org/articles/10.3389/fgene.2020.599548/full kostenfrei https://doaj.org/toc/1664-8021 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
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topic_facet	translatomics RNC-mRNA the nervous system polysome profiling ribosome profiling translating ribosome affinity purification Genetics
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container_title	Frontiers in Genetics
authorswithroles_txt_mv	Shuxia Zhang @@aut@@ Yeru Chen @@aut@@ Yongjie Wang @@aut@@ Piao Zhang @@aut@@ Gang Chen @@aut@@ Youfa Zhou @@aut@@
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callnumber-first	Q - Science
author	Shuxia Zhang
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topic_title	QH426-470 Insights Into Translatomics in the Nervous System translatomics RNC-mRNA the nervous system polysome profiling ribosome profiling translating ribosome affinity purification
topic	misc QH426-470 misc translatomics misc RNC-mRNA misc the nervous system misc polysome profiling misc ribosome profiling misc translating ribosome affinity purification misc Genetics
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title	Insights Into Translatomics in the Nervous System
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title_full	Insights Into Translatomics in the Nervous System
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title_auth	Insights Into Translatomics in the Nervous System
abstract	Most neurological disorders are caused by abnormal gene translation. Generally, dysregulation of elements involved in the translational process disrupts homeostasis in neurons and neuroglia. Better understanding of how the gene translation process occurs requires detailed analysis of transcriptomic and proteomic profile data. However, a lack of strictly direct correlations between mRNA and protein levels limits translational investigation by combining transcriptomic and proteomic profiling. The much better correlation between proteins and translated mRNAs than total mRNAs in abundance and insufficiently sensitive proteomics approach promote the requirement of advances in translatomics technology. Translatomics which capture and sequence the mRNAs associated with ribosomes has been effective in identifying translational changes by genetics or projections, ribosome stalling, local translation, and transcript isoforms in the nervous system. Here, we place emphasis on the main three translatomics methods currently used to profile mRNAs attached to ribosome-nascent chain complex (RNC-mRNA). Their prominent applications in neurological diseases including glioma, neuropathic pain, depression, fragile X syndrome (FXS), neurodegenerative disorders are outlined. The content reviewed here expands our understanding on the contributions of aberrant translation to neurological disease development.
abstractGer	Most neurological disorders are caused by abnormal gene translation. Generally, dysregulation of elements involved in the translational process disrupts homeostasis in neurons and neuroglia. Better understanding of how the gene translation process occurs requires detailed analysis of transcriptomic and proteomic profile data. However, a lack of strictly direct correlations between mRNA and protein levels limits translational investigation by combining transcriptomic and proteomic profiling. The much better correlation between proteins and translated mRNAs than total mRNAs in abundance and insufficiently sensitive proteomics approach promote the requirement of advances in translatomics technology. Translatomics which capture and sequence the mRNAs associated with ribosomes has been effective in identifying translational changes by genetics or projections, ribosome stalling, local translation, and transcript isoforms in the nervous system. Here, we place emphasis on the main three translatomics methods currently used to profile mRNAs attached to ribosome-nascent chain complex (RNC-mRNA). Their prominent applications in neurological diseases including glioma, neuropathic pain, depression, fragile X syndrome (FXS), neurodegenerative disorders are outlined. The content reviewed here expands our understanding on the contributions of aberrant translation to neurological disease development.
abstract_unstemmed	Most neurological disorders are caused by abnormal gene translation. Generally, dysregulation of elements involved in the translational process disrupts homeostasis in neurons and neuroglia. Better understanding of how the gene translation process occurs requires detailed analysis of transcriptomic and proteomic profile data. However, a lack of strictly direct correlations between mRNA and protein levels limits translational investigation by combining transcriptomic and proteomic profiling. The much better correlation between proteins and translated mRNAs than total mRNAs in abundance and insufficiently sensitive proteomics approach promote the requirement of advances in translatomics technology. Translatomics which capture and sequence the mRNAs associated with ribosomes has been effective in identifying translational changes by genetics or projections, ribosome stalling, local translation, and transcript isoforms in the nervous system. Here, we place emphasis on the main three translatomics methods currently used to profile mRNAs attached to ribosome-nascent chain complex (RNC-mRNA). Their prominent applications in neurological diseases including glioma, neuropathic pain, depression, fragile X syndrome (FXS), neurodegenerative disorders are outlined. The content reviewed here expands our understanding on the contributions of aberrant translation to neurological disease development.
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title_short	Insights Into Translatomics in the Nervous System
url	https://doi.org/10.3389/fgene.2020.599548 https://doaj.org/article/d41731179d274667954efc082c2e92e8 https://www.frontiersin.org/articles/10.3389/fgene.2020.599548/full https://doaj.org/toc/1664-8021
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