The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.

High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quanti...
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Autor*in:	Siguang Li [verfasserIn] Serena Sanna [verfasserIn] Andrea Maschio [verfasserIn] Fabio Busonero [verfasserIn] Gianluca Usala [verfasserIn] Antonella Mulas [verfasserIn] Sandra Lai [verfasserIn] Mariano Dei [verfasserIn] Marco Orrù [verfasserIn] Giuseppe Albai [verfasserIn] Stefania Bandinelli [verfasserIn] David Schlessinger [verfasserIn] Edward Lakatta [verfasserIn] Angelo Scuteri [verfasserIn] Samer S Najjar [verfasserIn] Jack Guralnik [verfasserIn] Silvia Naitza [verfasserIn] Laura Crisponi [verfasserIn] Antonio Cao [verfasserIn] Gonçalo Abecasis [verfasserIn] Luigi Ferrucci [verfasserIn] Manuela Uda [verfasserIn] Wei-Min Chen [verfasserIn] Ramaiah Nagaraja [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Übergeordnetes Werk:	In: PLoS Genetics - Public Library of Science (PLoS), 2005, 3(2007), 11, p e194
Übergeordnetes Werk:	volume:3 ; year:2007 ; number:11, p e194

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1371/journal.pgen.0030194

Katalog-ID:	DOAJ000942596

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520			\|a High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along with eight others (p = 7.75 x 10(-16) to 6.05 x 10(-11)). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values.
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allfields	10.1371/journal.pgen.0030194 doi (DE-627)DOAJ000942596 (DE-599)DOAJc60593e7ab224e6dadf50b9e691ab045 DE-627 ger DE-627 rakwb eng QH426-470 Siguang Li verfasserin aut The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along with eight others (p = 7.75 x 10(-16) to 6.05 x 10(-11)). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values. Genetics Serena Sanna verfasserin aut Andrea Maschio verfasserin aut Fabio Busonero verfasserin aut Gianluca Usala verfasserin aut Antonella Mulas verfasserin aut Sandra Lai verfasserin aut Mariano Dei verfasserin aut Marco Orrù verfasserin aut Giuseppe Albai verfasserin aut Stefania Bandinelli verfasserin aut David Schlessinger verfasserin aut Edward Lakatta verfasserin aut Angelo Scuteri verfasserin aut Samer S Najjar verfasserin aut Jack Guralnik verfasserin aut Silvia Naitza verfasserin aut Laura Crisponi verfasserin aut Antonio Cao verfasserin aut Gonçalo Abecasis verfasserin aut Luigi Ferrucci verfasserin aut Manuela Uda verfasserin aut Wei-Min Chen verfasserin aut Ramaiah Nagaraja verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 3(2007), 11, p e194 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:3 year:2007 number:11, p e194 https://doi.org/10.1371/journal.pgen.0030194 kostenfrei https://doaj.org/article/c60593e7ab224e6dadf50b9e691ab045 kostenfrei http://europepmc.org/articles/PMC2065883?pdf=render kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2007 11, p e194
spelling	10.1371/journal.pgen.0030194 doi (DE-627)DOAJ000942596 (DE-599)DOAJc60593e7ab224e6dadf50b9e691ab045 DE-627 ger DE-627 rakwb eng QH426-470 Siguang Li verfasserin aut The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along with eight others (p = 7.75 x 10(-16) to 6.05 x 10(-11)). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values. Genetics Serena Sanna verfasserin aut Andrea Maschio verfasserin aut Fabio Busonero verfasserin aut Gianluca Usala verfasserin aut Antonella Mulas verfasserin aut Sandra Lai verfasserin aut Mariano Dei verfasserin aut Marco Orrù verfasserin aut Giuseppe Albai verfasserin aut Stefania Bandinelli verfasserin aut David Schlessinger verfasserin aut Edward Lakatta verfasserin aut Angelo Scuteri verfasserin aut Samer S Najjar verfasserin aut Jack Guralnik verfasserin aut Silvia Naitza verfasserin aut Laura Crisponi verfasserin aut Antonio Cao verfasserin aut Gonçalo Abecasis verfasserin aut Luigi Ferrucci verfasserin aut Manuela Uda verfasserin aut Wei-Min Chen verfasserin aut Ramaiah Nagaraja verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 3(2007), 11, p e194 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:3 year:2007 number:11, p e194 https://doi.org/10.1371/journal.pgen.0030194 kostenfrei https://doaj.org/article/c60593e7ab224e6dadf50b9e691ab045 kostenfrei http://europepmc.org/articles/PMC2065883?pdf=render kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2007 11, p e194
allfields_unstemmed	10.1371/journal.pgen.0030194 doi (DE-627)DOAJ000942596 (DE-599)DOAJc60593e7ab224e6dadf50b9e691ab045 DE-627 ger DE-627 rakwb eng QH426-470 Siguang Li verfasserin aut The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along with eight others (p = 7.75 x 10(-16) to 6.05 x 10(-11)). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values. Genetics Serena Sanna verfasserin aut Andrea Maschio verfasserin aut Fabio Busonero verfasserin aut Gianluca Usala verfasserin aut Antonella Mulas verfasserin aut Sandra Lai verfasserin aut Mariano Dei verfasserin aut Marco Orrù verfasserin aut Giuseppe Albai verfasserin aut Stefania Bandinelli verfasserin aut David Schlessinger verfasserin aut Edward Lakatta verfasserin aut Angelo Scuteri verfasserin aut Samer S Najjar verfasserin aut Jack Guralnik verfasserin aut Silvia Naitza verfasserin aut Laura Crisponi verfasserin aut Antonio Cao verfasserin aut Gonçalo Abecasis verfasserin aut Luigi Ferrucci verfasserin aut Manuela Uda verfasserin aut Wei-Min Chen verfasserin aut Ramaiah Nagaraja verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 3(2007), 11, p e194 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:3 year:2007 number:11, p e194 https://doi.org/10.1371/journal.pgen.0030194 kostenfrei https://doaj.org/article/c60593e7ab224e6dadf50b9e691ab045 kostenfrei http://europepmc.org/articles/PMC2065883?pdf=render kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2007 11, p e194
allfieldsGer	10.1371/journal.pgen.0030194 doi (DE-627)DOAJ000942596 (DE-599)DOAJc60593e7ab224e6dadf50b9e691ab045 DE-627 ger DE-627 rakwb eng QH426-470 Siguang Li verfasserin aut The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along with eight others (p = 7.75 x 10(-16) to 6.05 x 10(-11)). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values. Genetics Serena Sanna verfasserin aut Andrea Maschio verfasserin aut Fabio Busonero verfasserin aut Gianluca Usala verfasserin aut Antonella Mulas verfasserin aut Sandra Lai verfasserin aut Mariano Dei verfasserin aut Marco Orrù verfasserin aut Giuseppe Albai verfasserin aut Stefania Bandinelli verfasserin aut David Schlessinger verfasserin aut Edward Lakatta verfasserin aut Angelo Scuteri verfasserin aut Samer S Najjar verfasserin aut Jack Guralnik verfasserin aut Silvia Naitza verfasserin aut Laura Crisponi verfasserin aut Antonio Cao verfasserin aut Gonçalo Abecasis verfasserin aut Luigi Ferrucci verfasserin aut Manuela Uda verfasserin aut Wei-Min Chen verfasserin aut Ramaiah Nagaraja verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 3(2007), 11, p e194 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:3 year:2007 number:11, p e194 https://doi.org/10.1371/journal.pgen.0030194 kostenfrei https://doaj.org/article/c60593e7ab224e6dadf50b9e691ab045 kostenfrei http://europepmc.org/articles/PMC2065883?pdf=render kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2007 11, p e194
allfieldsSound	10.1371/journal.pgen.0030194 doi (DE-627)DOAJ000942596 (DE-599)DOAJc60593e7ab224e6dadf50b9e691ab045 DE-627 ger DE-627 rakwb eng QH426-470 Siguang Li verfasserin aut The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along with eight others (p = 7.75 x 10(-16) to 6.05 x 10(-11)). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values. Genetics Serena Sanna verfasserin aut Andrea Maschio verfasserin aut Fabio Busonero verfasserin aut Gianluca Usala verfasserin aut Antonella Mulas verfasserin aut Sandra Lai verfasserin aut Mariano Dei verfasserin aut Marco Orrù verfasserin aut Giuseppe Albai verfasserin aut Stefania Bandinelli verfasserin aut David Schlessinger verfasserin aut Edward Lakatta verfasserin aut Angelo Scuteri verfasserin aut Samer S Najjar verfasserin aut Jack Guralnik verfasserin aut Silvia Naitza verfasserin aut Laura Crisponi verfasserin aut Antonio Cao verfasserin aut Gonçalo Abecasis verfasserin aut Luigi Ferrucci verfasserin aut Manuela Uda verfasserin aut Wei-Min Chen verfasserin aut Ramaiah Nagaraja verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 3(2007), 11, p e194 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:3 year:2007 number:11, p e194 https://doi.org/10.1371/journal.pgen.0030194 kostenfrei https://doaj.org/article/c60593e7ab224e6dadf50b9e691ab045 kostenfrei http://europepmc.org/articles/PMC2065883?pdf=render kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2007 11, p e194
language	English
source	In PLoS Genetics 3(2007), 11, p e194 volume:3 year:2007 number:11, p e194
sourceStr	In PLoS Genetics 3(2007), 11, p e194 volume:3 year:2007 number:11, p e194
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Genetics
isfreeaccess_bool	true
container_title	PLoS Genetics
authorswithroles_txt_mv	Siguang Li @@aut@@ Serena Sanna @@aut@@ Andrea Maschio @@aut@@ Fabio Busonero @@aut@@ Gianluca Usala @@aut@@ Antonella Mulas @@aut@@ Sandra Lai @@aut@@ Mariano Dei @@aut@@ Marco Orrù @@aut@@ Giuseppe Albai @@aut@@ Stefania Bandinelli @@aut@@ David Schlessinger @@aut@@ Edward Lakatta @@aut@@ Angelo Scuteri @@aut@@ Samer S Najjar @@aut@@ Jack Guralnik @@aut@@ Silvia Naitza @@aut@@ Laura Crisponi @@aut@@ Antonio Cao @@aut@@ Gonçalo Abecasis @@aut@@ Luigi Ferrucci @@aut@@ Manuela Uda @@aut@@ Wei-Min Chen @@aut@@ Ramaiah Nagaraja @@aut@@
publishDateDaySort_date	2007-01-01T00:00:00Z
hierarchy_top_id	485248026
id	DOAJ000942596
language_de	englisch
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author	Siguang Li
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topic_title	QH426-470 The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts
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title	The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.
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title_full	The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts
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author_browse	Siguang Li Serena Sanna Andrea Maschio Fabio Busonero Gianluca Usala Antonella Mulas Sandra Lai Mariano Dei Marco Orrù Giuseppe Albai Stefania Bandinelli David Schlessinger Edward Lakatta Angelo Scuteri Samer S Najjar Jack Guralnik Silvia Naitza Laura Crisponi Antonio Cao Gonçalo Abecasis Luigi Ferrucci Manuela Uda Wei-Min Chen Ramaiah Nagaraja
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title_sort	glut9 gene is associated with serum uric acid levels in sardinia and chianti cohorts
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title_auth	The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.
abstract	High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along with eight others (p = 7.75 x 10(-16) to 6.05 x 10(-11)). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values.
abstractGer	High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along with eight others (p = 7.75 x 10(-16) to 6.05 x 10(-11)). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values.
abstract_unstemmed	High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along with eight others (p = 7.75 x 10(-16) to 6.05 x 10(-11)). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values.
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title_short	The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.
url	https://doi.org/10.1371/journal.pgen.0030194 https://doaj.org/article/c60593e7ab224e6dadf50b9e691ab045 http://europepmc.org/articles/PMC2065883?pdf=render https://doaj.org/toc/1553-7390 https://doaj.org/toc/1553-7404
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The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.

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