Effects of nitric oxide on reproductive organs and related physiological processes
Nitric oxide (NO), a member of the reactive nitrogen species family, plays a role in several physiologic processes, including vasculogenesis and angiogenesis, growth and puberty, and senescence and apoptosis. NO plays an important role in the production of ovarian steroids, ovulation, and follicular...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ayoob Rostamzadeh [verfasserIn] Reza Ahmadi [verfasserIn] Mahdi Heydari [verfasserIn] Amir Raoofi [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2020 |
|---|
| Schlagwörter: |
reproduction; nitric oxide; nitric oxide synthase; cell signaling; oxidants |
|---|
| Übergeordnetes Werk: |
In: Asian Pacific Journal of Reproduction - Wolters Kluwer Medknow Publications, 2017, 9(2020), 4, Seite 159-165 |
|---|---|
| Übergeordnetes Werk: |
volume:9 ; year:2020 ; number:4 ; pages:159-165 |
| Links: |
Link aufrufen |
|---|
| DOI / URN: |
10.4103/2305-0500.288583 |
|---|
| Katalog-ID: |
DOAJ000967742 |
|---|
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| 520 | |a Nitric oxide (NO), a member of the reactive nitrogen species family, plays a role in several physiologic processes, including vasculogenesis and angiogenesis, growth and puberty, and senescence and apoptosis. NO plays an important role in the production of ovarian steroids, ovulation, and follicular apoptosis. In other words, increased activity of nitric oxide synthase (NOS) leads to an increased amount of NO, which triggers production of prostaglandins and inflammatory cascades which facilitate follicular rupture and atresia. NO concentration elevation inhibits steroid synthesis in luteal and granulosa cells. Since NO is a major paracrine mediator of various biological processes, as well as a key factor in both the reproductive cycle and embryo implantation, oversynthesis of NO in the uterus results in toxicity and inflammation in epithelial cells and immunorejection of implantation. In the male physiological system, NO synthesized by NOS plays a major role in erectile function and androgen secretion, as well as semen parameters, and oocyte junction to the sperm. Furthermore, this supposedly simple molecule is involved in a number of other functions, such as germ cell evolution, connections between sertoli cells and germ cells in the blood-testis barrier, homodynamic contraction, and germ cell apoptosis. Moreover, NO is considered a key factor in male fertility due to its widespread distribution in both normal and diseased testis tissue. The difference of expression level of NOS in normal and pathological states is a probable cause of fertility destructive processes. | ||
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10.4103/2305-0500.288583 doi (DE-627)DOAJ000967742 (DE-599)DOAJ298a13670d3a4d59909a6e723dcd81bf DE-627 ger DE-627 rakwb eng Ayoob Rostamzadeh verfasserin aut Effects of nitric oxide on reproductive organs and related physiological processes 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nitric oxide (NO), a member of the reactive nitrogen species family, plays a role in several physiologic processes, including vasculogenesis and angiogenesis, growth and puberty, and senescence and apoptosis. NO plays an important role in the production of ovarian steroids, ovulation, and follicular apoptosis. In other words, increased activity of nitric oxide synthase (NOS) leads to an increased amount of NO, which triggers production of prostaglandins and inflammatory cascades which facilitate follicular rupture and atresia. NO concentration elevation inhibits steroid synthesis in luteal and granulosa cells. Since NO is a major paracrine mediator of various biological processes, as well as a key factor in both the reproductive cycle and embryo implantation, oversynthesis of NO in the uterus results in toxicity and inflammation in epithelial cells and immunorejection of implantation. In the male physiological system, NO synthesized by NOS plays a major role in erectile function and androgen secretion, as well as semen parameters, and oocyte junction to the sperm. Furthermore, this supposedly simple molecule is involved in a number of other functions, such as germ cell evolution, connections between sertoli cells and germ cells in the blood-testis barrier, homodynamic contraction, and germ cell apoptosis. Moreover, NO is considered a key factor in male fertility due to its widespread distribution in both normal and diseased testis tissue. The difference of expression level of NOS in normal and pathological states is a probable cause of fertility destructive processes. reproduction; nitric oxide; nitric oxide synthase; cell signaling; oxidants Medicine R Reza Ahmadi verfasserin aut Mahdi Heydari verfasserin aut Amir Raoofi verfasserin aut In Asian Pacific Journal of Reproduction Wolters Kluwer Medknow Publications, 2017 9(2020), 4, Seite 159-165 (DE-627)775904678 (DE-600)2747542-6 23050519 nnns volume:9 year:2020 number:4 pages:159-165 https://doi.org/10.4103/2305-0500.288583 kostenfrei https://doaj.org/article/298a13670d3a4d59909a6e723dcd81bf kostenfrei http://www.apjr.net/article.asp?issn=2305-0500;year=2020;volume=9;issue=4;spage=159;epage=165;aulast=Rostamzadeh kostenfrei https://doaj.org/toc/2305-0500 Journal toc kostenfrei https://doaj.org/toc/2305-0519 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2004 GBV_ILN_2336 AR 9 2020 4 159-165 |
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10.4103/2305-0500.288583 doi (DE-627)DOAJ000967742 (DE-599)DOAJ298a13670d3a4d59909a6e723dcd81bf DE-627 ger DE-627 rakwb eng Ayoob Rostamzadeh verfasserin aut Effects of nitric oxide on reproductive organs and related physiological processes 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nitric oxide (NO), a member of the reactive nitrogen species family, plays a role in several physiologic processes, including vasculogenesis and angiogenesis, growth and puberty, and senescence and apoptosis. NO plays an important role in the production of ovarian steroids, ovulation, and follicular apoptosis. In other words, increased activity of nitric oxide synthase (NOS) leads to an increased amount of NO, which triggers production of prostaglandins and inflammatory cascades which facilitate follicular rupture and atresia. NO concentration elevation inhibits steroid synthesis in luteal and granulosa cells. Since NO is a major paracrine mediator of various biological processes, as well as a key factor in both the reproductive cycle and embryo implantation, oversynthesis of NO in the uterus results in toxicity and inflammation in epithelial cells and immunorejection of implantation. In the male physiological system, NO synthesized by NOS plays a major role in erectile function and androgen secretion, as well as semen parameters, and oocyte junction to the sperm. Furthermore, this supposedly simple molecule is involved in a number of other functions, such as germ cell evolution, connections between sertoli cells and germ cells in the blood-testis barrier, homodynamic contraction, and germ cell apoptosis. Moreover, NO is considered a key factor in male fertility due to its widespread distribution in both normal and diseased testis tissue. The difference of expression level of NOS in normal and pathological states is a probable cause of fertility destructive processes. reproduction; nitric oxide; nitric oxide synthase; cell signaling; oxidants Medicine R Reza Ahmadi verfasserin aut Mahdi Heydari verfasserin aut Amir Raoofi verfasserin aut In Asian Pacific Journal of Reproduction Wolters Kluwer Medknow Publications, 2017 9(2020), 4, Seite 159-165 (DE-627)775904678 (DE-600)2747542-6 23050519 nnns volume:9 year:2020 number:4 pages:159-165 https://doi.org/10.4103/2305-0500.288583 kostenfrei https://doaj.org/article/298a13670d3a4d59909a6e723dcd81bf kostenfrei http://www.apjr.net/article.asp?issn=2305-0500;year=2020;volume=9;issue=4;spage=159;epage=165;aulast=Rostamzadeh kostenfrei https://doaj.org/toc/2305-0500 Journal toc kostenfrei https://doaj.org/toc/2305-0519 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2004 GBV_ILN_2336 AR 9 2020 4 159-165 |
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Effects of nitric oxide on reproductive organs and related physiological processes |
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Effects of nitric oxide on reproductive organs and related physiological processes |
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Ayoob Rostamzadeh |
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Ayoob Rostamzadeh Reza Ahmadi Mahdi Heydari Amir Raoofi |
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effects of nitric oxide on reproductive organs and related physiological processes |
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Effects of nitric oxide on reproductive organs and related physiological processes |
| abstract |
Nitric oxide (NO), a member of the reactive nitrogen species family, plays a role in several physiologic processes, including vasculogenesis and angiogenesis, growth and puberty, and senescence and apoptosis. NO plays an important role in the production of ovarian steroids, ovulation, and follicular apoptosis. In other words, increased activity of nitric oxide synthase (NOS) leads to an increased amount of NO, which triggers production of prostaglandins and inflammatory cascades which facilitate follicular rupture and atresia. NO concentration elevation inhibits steroid synthesis in luteal and granulosa cells. Since NO is a major paracrine mediator of various biological processes, as well as a key factor in both the reproductive cycle and embryo implantation, oversynthesis of NO in the uterus results in toxicity and inflammation in epithelial cells and immunorejection of implantation. In the male physiological system, NO synthesized by NOS plays a major role in erectile function and androgen secretion, as well as semen parameters, and oocyte junction to the sperm. Furthermore, this supposedly simple molecule is involved in a number of other functions, such as germ cell evolution, connections between sertoli cells and germ cells in the blood-testis barrier, homodynamic contraction, and germ cell apoptosis. Moreover, NO is considered a key factor in male fertility due to its widespread distribution in both normal and diseased testis tissue. The difference of expression level of NOS in normal and pathological states is a probable cause of fertility destructive processes. |
| abstractGer |
Nitric oxide (NO), a member of the reactive nitrogen species family, plays a role in several physiologic processes, including vasculogenesis and angiogenesis, growth and puberty, and senescence and apoptosis. NO plays an important role in the production of ovarian steroids, ovulation, and follicular apoptosis. In other words, increased activity of nitric oxide synthase (NOS) leads to an increased amount of NO, which triggers production of prostaglandins and inflammatory cascades which facilitate follicular rupture and atresia. NO concentration elevation inhibits steroid synthesis in luteal and granulosa cells. Since NO is a major paracrine mediator of various biological processes, as well as a key factor in both the reproductive cycle and embryo implantation, oversynthesis of NO in the uterus results in toxicity and inflammation in epithelial cells and immunorejection of implantation. In the male physiological system, NO synthesized by NOS plays a major role in erectile function and androgen secretion, as well as semen parameters, and oocyte junction to the sperm. Furthermore, this supposedly simple molecule is involved in a number of other functions, such as germ cell evolution, connections between sertoli cells and germ cells in the blood-testis barrier, homodynamic contraction, and germ cell apoptosis. Moreover, NO is considered a key factor in male fertility due to its widespread distribution in both normal and diseased testis tissue. The difference of expression level of NOS in normal and pathological states is a probable cause of fertility destructive processes. |
| abstract_unstemmed |
Nitric oxide (NO), a member of the reactive nitrogen species family, plays a role in several physiologic processes, including vasculogenesis and angiogenesis, growth and puberty, and senescence and apoptosis. NO plays an important role in the production of ovarian steroids, ovulation, and follicular apoptosis. In other words, increased activity of nitric oxide synthase (NOS) leads to an increased amount of NO, which triggers production of prostaglandins and inflammatory cascades which facilitate follicular rupture and atresia. NO concentration elevation inhibits steroid synthesis in luteal and granulosa cells. Since NO is a major paracrine mediator of various biological processes, as well as a key factor in both the reproductive cycle and embryo implantation, oversynthesis of NO in the uterus results in toxicity and inflammation in epithelial cells and immunorejection of implantation. In the male physiological system, NO synthesized by NOS plays a major role in erectile function and androgen secretion, as well as semen parameters, and oocyte junction to the sperm. Furthermore, this supposedly simple molecule is involved in a number of other functions, such as germ cell evolution, connections between sertoli cells and germ cells in the blood-testis barrier, homodynamic contraction, and germ cell apoptosis. Moreover, NO is considered a key factor in male fertility due to its widespread distribution in both normal and diseased testis tissue. The difference of expression level of NOS in normal and pathological states is a probable cause of fertility destructive processes. |
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