Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls
Introduction: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly dr...
Ausführliche Beschreibung
Autor*in: |
Johanna Gechter [verfasserIn] Carolin Liebscher [verfasserIn] Maximilian J. Geiger [verfasserIn] André Wittmann [verfasserIn] Florian Schlagenhauf [verfasserIn] Ulrike Lueken [verfasserIn] Hans-Ulrich Wittchen [verfasserIn] Bettina Pfleiderer [verfasserIn] Volker Arolt [verfasserIn] Tilo Kircher [verfasserIn] Benjamin Straube [verfasserIn] Jürgen Deckert [verfasserIn] Heike Weber [verfasserIn] Martin J. Herrmann [verfasserIn] Andreas Reif [verfasserIn] Katharina Domschke [verfasserIn] Andreas Ströhle [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2019 |
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Übergeordnetes Werk: |
In: NeuroImage: Clinical - Elsevier, 2015, 24(2019), Seite - |
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Übergeordnetes Werk: |
volume:24 ; year:2019 ; pages:- |
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DOI / URN: |
10.1016/j.nicl.2019.102029 |
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Katalog-ID: |
DOAJ000996637 |
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520 | |a Introduction: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural “fear network”. We aimed to investigate whether the NPSR1 T risk allele was associated with malfunctioning in a fronto-limbic network during the anticipation and perception of agoraphobia-specific stimuli. Method: 121 patients with PD/AG and 77 healthy controls (HC) underwent functional magnetic resonance imaging (fMRI) using the disorder specific “Westphal-Paradigm”. It consists of neutral and agoraphobia-specific pictures, half of the pictures were cued to induce anticipatory anxiety. Results: Risk allele carriers showed significantly higher amygdala activation during the perception of agoraphobia-specific stimuli than A/A homozygotes. A linear group x genotype interaction during the perception of agoraphobia-specific stimuli showed a strong trend towards significance. Patients with the one or two T alleles displayed the highest and HC with the A/A genotype the lowest activation in the inferior orbitofrontal cortex (iOFC). Discussion: The study demonstrates an association of the NPSR1rs324981 genotype and the perception of agoraphobia-specific stimuli. These results support the assumption of a fronto-limbic dysfunction as an intermediate phenotype of PD/AG. Keywords: Panic disorder, Agoraphobia, NPSR1, Imaging genetics, fMRI, Westphal-Paradigm | ||
653 | 0 | |a Computer applications to medicine. Medical informatics | |
653 | 0 | |a Neurology. Diseases of the nervous system | |
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700 | 0 | |a Maximilian J. Geiger |e verfasserin |4 aut | |
700 | 0 | |a André Wittmann |e verfasserin |4 aut | |
700 | 0 | |a Florian Schlagenhauf |e verfasserin |4 aut | |
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700 | 0 | |a Andreas Reif |e verfasserin |4 aut | |
700 | 0 | |a Katharina Domschke |e verfasserin |4 aut | |
700 | 0 | |a Andreas Ströhle |e verfasserin |4 aut | |
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10.1016/j.nicl.2019.102029 doi (DE-627)DOAJ000996637 (DE-599)DOAJef90c69144984fc28b3e9469a1141005 DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Johanna Gechter verfasserin aut Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural “fear network”. We aimed to investigate whether the NPSR1 T risk allele was associated with malfunctioning in a fronto-limbic network during the anticipation and perception of agoraphobia-specific stimuli. Method: 121 patients with PD/AG and 77 healthy controls (HC) underwent functional magnetic resonance imaging (fMRI) using the disorder specific “Westphal-Paradigm”. It consists of neutral and agoraphobia-specific pictures, half of the pictures were cued to induce anticipatory anxiety. Results: Risk allele carriers showed significantly higher amygdala activation during the perception of agoraphobia-specific stimuli than A/A homozygotes. A linear group x genotype interaction during the perception of agoraphobia-specific stimuli showed a strong trend towards significance. Patients with the one or two T alleles displayed the highest and HC with the A/A genotype the lowest activation in the inferior orbitofrontal cortex (iOFC). Discussion: The study demonstrates an association of the NPSR1rs324981 genotype and the perception of agoraphobia-specific stimuli. These results support the assumption of a fronto-limbic dysfunction as an intermediate phenotype of PD/AG. Keywords: Panic disorder, Agoraphobia, NPSR1, Imaging genetics, fMRI, Westphal-Paradigm Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Carolin Liebscher verfasserin aut Maximilian J. Geiger verfasserin aut André Wittmann verfasserin aut Florian Schlagenhauf verfasserin aut Ulrike Lueken verfasserin aut Hans-Ulrich Wittchen verfasserin aut Bettina Pfleiderer verfasserin aut Volker Arolt verfasserin aut Tilo Kircher verfasserin aut Benjamin Straube verfasserin aut Jürgen Deckert verfasserin aut Heike Weber verfasserin aut Martin J. Herrmann verfasserin aut Andreas Reif verfasserin aut Katharina Domschke verfasserin aut Andreas Ströhle verfasserin aut In NeuroImage: Clinical Elsevier, 2015 24(2019), Seite - (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:24 year:2019 pages:- https://doi.org/10.1016/j.nicl.2019.102029 kostenfrei https://doaj.org/article/ef90c69144984fc28b3e9469a1141005 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158219303791 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2019 - |
spelling |
10.1016/j.nicl.2019.102029 doi (DE-627)DOAJ000996637 (DE-599)DOAJef90c69144984fc28b3e9469a1141005 DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Johanna Gechter verfasserin aut Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural “fear network”. We aimed to investigate whether the NPSR1 T risk allele was associated with malfunctioning in a fronto-limbic network during the anticipation and perception of agoraphobia-specific stimuli. Method: 121 patients with PD/AG and 77 healthy controls (HC) underwent functional magnetic resonance imaging (fMRI) using the disorder specific “Westphal-Paradigm”. It consists of neutral and agoraphobia-specific pictures, half of the pictures were cued to induce anticipatory anxiety. Results: Risk allele carriers showed significantly higher amygdala activation during the perception of agoraphobia-specific stimuli than A/A homozygotes. A linear group x genotype interaction during the perception of agoraphobia-specific stimuli showed a strong trend towards significance. Patients with the one or two T alleles displayed the highest and HC with the A/A genotype the lowest activation in the inferior orbitofrontal cortex (iOFC). Discussion: The study demonstrates an association of the NPSR1rs324981 genotype and the perception of agoraphobia-specific stimuli. These results support the assumption of a fronto-limbic dysfunction as an intermediate phenotype of PD/AG. Keywords: Panic disorder, Agoraphobia, NPSR1, Imaging genetics, fMRI, Westphal-Paradigm Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Carolin Liebscher verfasserin aut Maximilian J. Geiger verfasserin aut André Wittmann verfasserin aut Florian Schlagenhauf verfasserin aut Ulrike Lueken verfasserin aut Hans-Ulrich Wittchen verfasserin aut Bettina Pfleiderer verfasserin aut Volker Arolt verfasserin aut Tilo Kircher verfasserin aut Benjamin Straube verfasserin aut Jürgen Deckert verfasserin aut Heike Weber verfasserin aut Martin J. Herrmann verfasserin aut Andreas Reif verfasserin aut Katharina Domschke verfasserin aut Andreas Ströhle verfasserin aut In NeuroImage: Clinical Elsevier, 2015 24(2019), Seite - (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:24 year:2019 pages:- https://doi.org/10.1016/j.nicl.2019.102029 kostenfrei https://doaj.org/article/ef90c69144984fc28b3e9469a1141005 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158219303791 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2019 - |
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10.1016/j.nicl.2019.102029 doi (DE-627)DOAJ000996637 (DE-599)DOAJef90c69144984fc28b3e9469a1141005 DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Johanna Gechter verfasserin aut Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural “fear network”. We aimed to investigate whether the NPSR1 T risk allele was associated with malfunctioning in a fronto-limbic network during the anticipation and perception of agoraphobia-specific stimuli. Method: 121 patients with PD/AG and 77 healthy controls (HC) underwent functional magnetic resonance imaging (fMRI) using the disorder specific “Westphal-Paradigm”. It consists of neutral and agoraphobia-specific pictures, half of the pictures were cued to induce anticipatory anxiety. Results: Risk allele carriers showed significantly higher amygdala activation during the perception of agoraphobia-specific stimuli than A/A homozygotes. A linear group x genotype interaction during the perception of agoraphobia-specific stimuli showed a strong trend towards significance. Patients with the one or two T alleles displayed the highest and HC with the A/A genotype the lowest activation in the inferior orbitofrontal cortex (iOFC). Discussion: The study demonstrates an association of the NPSR1rs324981 genotype and the perception of agoraphobia-specific stimuli. These results support the assumption of a fronto-limbic dysfunction as an intermediate phenotype of PD/AG. Keywords: Panic disorder, Agoraphobia, NPSR1, Imaging genetics, fMRI, Westphal-Paradigm Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Carolin Liebscher verfasserin aut Maximilian J. Geiger verfasserin aut André Wittmann verfasserin aut Florian Schlagenhauf verfasserin aut Ulrike Lueken verfasserin aut Hans-Ulrich Wittchen verfasserin aut Bettina Pfleiderer verfasserin aut Volker Arolt verfasserin aut Tilo Kircher verfasserin aut Benjamin Straube verfasserin aut Jürgen Deckert verfasserin aut Heike Weber verfasserin aut Martin J. Herrmann verfasserin aut Andreas Reif verfasserin aut Katharina Domschke verfasserin aut Andreas Ströhle verfasserin aut In NeuroImage: Clinical Elsevier, 2015 24(2019), Seite - (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:24 year:2019 pages:- https://doi.org/10.1016/j.nicl.2019.102029 kostenfrei https://doaj.org/article/ef90c69144984fc28b3e9469a1141005 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158219303791 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2019 - |
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10.1016/j.nicl.2019.102029 doi (DE-627)DOAJ000996637 (DE-599)DOAJef90c69144984fc28b3e9469a1141005 DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Johanna Gechter verfasserin aut Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural “fear network”. We aimed to investigate whether the NPSR1 T risk allele was associated with malfunctioning in a fronto-limbic network during the anticipation and perception of agoraphobia-specific stimuli. Method: 121 patients with PD/AG and 77 healthy controls (HC) underwent functional magnetic resonance imaging (fMRI) using the disorder specific “Westphal-Paradigm”. It consists of neutral and agoraphobia-specific pictures, half of the pictures were cued to induce anticipatory anxiety. Results: Risk allele carriers showed significantly higher amygdala activation during the perception of agoraphobia-specific stimuli than A/A homozygotes. A linear group x genotype interaction during the perception of agoraphobia-specific stimuli showed a strong trend towards significance. Patients with the one or two T alleles displayed the highest and HC with the A/A genotype the lowest activation in the inferior orbitofrontal cortex (iOFC). Discussion: The study demonstrates an association of the NPSR1rs324981 genotype and the perception of agoraphobia-specific stimuli. These results support the assumption of a fronto-limbic dysfunction as an intermediate phenotype of PD/AG. Keywords: Panic disorder, Agoraphobia, NPSR1, Imaging genetics, fMRI, Westphal-Paradigm Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Carolin Liebscher verfasserin aut Maximilian J. Geiger verfasserin aut André Wittmann verfasserin aut Florian Schlagenhauf verfasserin aut Ulrike Lueken verfasserin aut Hans-Ulrich Wittchen verfasserin aut Bettina Pfleiderer verfasserin aut Volker Arolt verfasserin aut Tilo Kircher verfasserin aut Benjamin Straube verfasserin aut Jürgen Deckert verfasserin aut Heike Weber verfasserin aut Martin J. Herrmann verfasserin aut Andreas Reif verfasserin aut Katharina Domschke verfasserin aut Andreas Ströhle verfasserin aut In NeuroImage: Clinical Elsevier, 2015 24(2019), Seite - (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:24 year:2019 pages:- https://doi.org/10.1016/j.nicl.2019.102029 kostenfrei https://doaj.org/article/ef90c69144984fc28b3e9469a1141005 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158219303791 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2019 - |
allfieldsSound |
10.1016/j.nicl.2019.102029 doi (DE-627)DOAJ000996637 (DE-599)DOAJef90c69144984fc28b3e9469a1141005 DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Johanna Gechter verfasserin aut Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural “fear network”. We aimed to investigate whether the NPSR1 T risk allele was associated with malfunctioning in a fronto-limbic network during the anticipation and perception of agoraphobia-specific stimuli. Method: 121 patients with PD/AG and 77 healthy controls (HC) underwent functional magnetic resonance imaging (fMRI) using the disorder specific “Westphal-Paradigm”. It consists of neutral and agoraphobia-specific pictures, half of the pictures were cued to induce anticipatory anxiety. Results: Risk allele carriers showed significantly higher amygdala activation during the perception of agoraphobia-specific stimuli than A/A homozygotes. A linear group x genotype interaction during the perception of agoraphobia-specific stimuli showed a strong trend towards significance. Patients with the one or two T alleles displayed the highest and HC with the A/A genotype the lowest activation in the inferior orbitofrontal cortex (iOFC). Discussion: The study demonstrates an association of the NPSR1rs324981 genotype and the perception of agoraphobia-specific stimuli. These results support the assumption of a fronto-limbic dysfunction as an intermediate phenotype of PD/AG. Keywords: Panic disorder, Agoraphobia, NPSR1, Imaging genetics, fMRI, Westphal-Paradigm Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Carolin Liebscher verfasserin aut Maximilian J. Geiger verfasserin aut André Wittmann verfasserin aut Florian Schlagenhauf verfasserin aut Ulrike Lueken verfasserin aut Hans-Ulrich Wittchen verfasserin aut Bettina Pfleiderer verfasserin aut Volker Arolt verfasserin aut Tilo Kircher verfasserin aut Benjamin Straube verfasserin aut Jürgen Deckert verfasserin aut Heike Weber verfasserin aut Martin J. Herrmann verfasserin aut Andreas Reif verfasserin aut Katharina Domschke verfasserin aut Andreas Ströhle verfasserin aut In NeuroImage: Clinical Elsevier, 2015 24(2019), Seite - (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:24 year:2019 pages:- https://doi.org/10.1016/j.nicl.2019.102029 kostenfrei https://doaj.org/article/ef90c69144984fc28b3e9469a1141005 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158219303791 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2019 - |
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Johanna Gechter @@aut@@ Carolin Liebscher @@aut@@ Maximilian J. Geiger @@aut@@ André Wittmann @@aut@@ Florian Schlagenhauf @@aut@@ Ulrike Lueken @@aut@@ Hans-Ulrich Wittchen @@aut@@ Bettina Pfleiderer @@aut@@ Volker Arolt @@aut@@ Tilo Kircher @@aut@@ Benjamin Straube @@aut@@ Jürgen Deckert @@aut@@ Heike Weber @@aut@@ Martin J. Herrmann @@aut@@ Andreas Reif @@aut@@ Katharina Domschke @@aut@@ Andreas Ströhle @@aut@@ |
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Johanna Gechter |
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Johanna Gechter misc R858-859.7 misc RC346-429 misc Computer applications to medicine. Medical informatics misc Neurology. Diseases of the nervous system Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls |
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R858-859.7 RC346-429 Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls |
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misc R858-859.7 misc RC346-429 misc Computer applications to medicine. Medical informatics misc Neurology. Diseases of the nervous system |
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Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls |
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Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls |
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Johanna Gechter Carolin Liebscher Maximilian J. Geiger André Wittmann Florian Schlagenhauf Ulrike Lueken Hans-Ulrich Wittchen Bettina Pfleiderer Volker Arolt Tilo Kircher Benjamin Straube Jürgen Deckert Heike Weber Martin J. Herrmann Andreas Reif Katharina Domschke Andreas Ströhle |
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10.1016/j.nicl.2019.102029 |
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association of npsr1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls |
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R858-859.7 |
title_auth |
Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls |
abstract |
Introduction: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural “fear network”. We aimed to investigate whether the NPSR1 T risk allele was associated with malfunctioning in a fronto-limbic network during the anticipation and perception of agoraphobia-specific stimuli. Method: 121 patients with PD/AG and 77 healthy controls (HC) underwent functional magnetic resonance imaging (fMRI) using the disorder specific “Westphal-Paradigm”. It consists of neutral and agoraphobia-specific pictures, half of the pictures were cued to induce anticipatory anxiety. Results: Risk allele carriers showed significantly higher amygdala activation during the perception of agoraphobia-specific stimuli than A/A homozygotes. A linear group x genotype interaction during the perception of agoraphobia-specific stimuli showed a strong trend towards significance. Patients with the one or two T alleles displayed the highest and HC with the A/A genotype the lowest activation in the inferior orbitofrontal cortex (iOFC). Discussion: The study demonstrates an association of the NPSR1rs324981 genotype and the perception of agoraphobia-specific stimuli. These results support the assumption of a fronto-limbic dysfunction as an intermediate phenotype of PD/AG. Keywords: Panic disorder, Agoraphobia, NPSR1, Imaging genetics, fMRI, Westphal-Paradigm |
abstractGer |
Introduction: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural “fear network”. We aimed to investigate whether the NPSR1 T risk allele was associated with malfunctioning in a fronto-limbic network during the anticipation and perception of agoraphobia-specific stimuli. Method: 121 patients with PD/AG and 77 healthy controls (HC) underwent functional magnetic resonance imaging (fMRI) using the disorder specific “Westphal-Paradigm”. It consists of neutral and agoraphobia-specific pictures, half of the pictures were cued to induce anticipatory anxiety. Results: Risk allele carriers showed significantly higher amygdala activation during the perception of agoraphobia-specific stimuli than A/A homozygotes. A linear group x genotype interaction during the perception of agoraphobia-specific stimuli showed a strong trend towards significance. Patients with the one or two T alleles displayed the highest and HC with the A/A genotype the lowest activation in the inferior orbitofrontal cortex (iOFC). Discussion: The study demonstrates an association of the NPSR1rs324981 genotype and the perception of agoraphobia-specific stimuli. These results support the assumption of a fronto-limbic dysfunction as an intermediate phenotype of PD/AG. Keywords: Panic disorder, Agoraphobia, NPSR1, Imaging genetics, fMRI, Westphal-Paradigm |
abstract_unstemmed |
Introduction: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural “fear network”. We aimed to investigate whether the NPSR1 T risk allele was associated with malfunctioning in a fronto-limbic network during the anticipation and perception of agoraphobia-specific stimuli. Method: 121 patients with PD/AG and 77 healthy controls (HC) underwent functional magnetic resonance imaging (fMRI) using the disorder specific “Westphal-Paradigm”. It consists of neutral and agoraphobia-specific pictures, half of the pictures were cued to induce anticipatory anxiety. Results: Risk allele carriers showed significantly higher amygdala activation during the perception of agoraphobia-specific stimuli than A/A homozygotes. A linear group x genotype interaction during the perception of agoraphobia-specific stimuli showed a strong trend towards significance. Patients with the one or two T alleles displayed the highest and HC with the A/A genotype the lowest activation in the inferior orbitofrontal cortex (iOFC). Discussion: The study demonstrates an association of the NPSR1rs324981 genotype and the perception of agoraphobia-specific stimuli. These results support the assumption of a fronto-limbic dysfunction as an intermediate phenotype of PD/AG. Keywords: Panic disorder, Agoraphobia, NPSR1, Imaging genetics, fMRI, Westphal-Paradigm |
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Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls |
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https://doi.org/10.1016/j.nicl.2019.102029 https://doaj.org/article/ef90c69144984fc28b3e9469a1141005 http://www.sciencedirect.com/science/article/pii/S2213158219303791 https://doaj.org/toc/2213-1582 |
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Carolin Liebscher Maximilian J. Geiger André Wittmann Florian Schlagenhauf Ulrike Lueken Hans-Ulrich Wittchen Bettina Pfleiderer Volker Arolt Tilo Kircher Benjamin Straube Jürgen Deckert Heike Weber Martin J. Herrmann Andreas Reif Katharina Domschke Andreas Ströhle |
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Carolin Liebscher Maximilian J. Geiger André Wittmann Florian Schlagenhauf Ulrike Lueken Hans-Ulrich Wittchen Bettina Pfleiderer Volker Arolt Tilo Kircher Benjamin Straube Jürgen Deckert Heike Weber Martin J. Herrmann Andreas Reif Katharina Domschke Andreas Ströhle |
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R - General Medicine |
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10.1016/j.nicl.2019.102029 |
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R858-859.7 |
up_date |
2024-07-03T17:46:49.638Z |
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The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural “fear network”. We aimed to investigate whether the NPSR1 T risk allele was associated with malfunctioning in a fronto-limbic network during the anticipation and perception of agoraphobia-specific stimuli. Method: 121 patients with PD/AG and 77 healthy controls (HC) underwent functional magnetic resonance imaging (fMRI) using the disorder specific “Westphal-Paradigm”. It consists of neutral and agoraphobia-specific pictures, half of the pictures were cued to induce anticipatory anxiety. Results: Risk allele carriers showed significantly higher amygdala activation during the perception of agoraphobia-specific stimuli than A/A homozygotes. A linear group x genotype interaction during the perception of agoraphobia-specific stimuli showed a strong trend towards significance. Patients with the one or two T alleles displayed the highest and HC with the A/A genotype the lowest activation in the inferior orbitofrontal cortex (iOFC). Discussion: The study demonstrates an association of the NPSR1rs324981 genotype and the perception of agoraphobia-specific stimuli. These results support the assumption of a fronto-limbic dysfunction as an intermediate phenotype of PD/AG. Keywords: Panic disorder, Agoraphobia, NPSR1, Imaging genetics, fMRI, Westphal-Paradigm</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Computer applications to medicine. Medical informatics</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neurology. 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