Adverse childhood experiences and biomarkers of inflammation in a diverse cohort of early school-aged children
Objective: The objective of this study was to evaluate the relationship between ACEs and inflammatory profiles (i.e., pro- and anti-) in early childhood and to examine whether patterns differ for racial/ethnic subgroups. Study design: Using longitudinal data from the Multidimensional Assessment of P...
Ausführliche Beschreibung
Autor*in: |
Nia Heard-Garris [verfasserIn] Matthew M. Davis [verfasserIn] Ryne Estabrook [verfasserIn] James Burns [verfasserIn] Margaret Briggs-Gowan [verfasserIn] Norrina Allen [verfasserIn] Mercedes Carnethon [verfasserIn] Liliana Aguayo [verfasserIn] Lauren Wakschlag [verfasserIn] Frank Penedo [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Übergeordnetes Werk: |
In: Brain, Behavior, & Immunity - Health - Elsevier, 2021, 1(2020), Seite 100006- |
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Übergeordnetes Werk: |
volume:1 ; year:2020 ; pages:100006- |
Links: |
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DOI / URN: |
10.1016/j.bbih.2019.100006 |
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Katalog-ID: |
DOAJ001046977 |
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520 | |a Objective: The objective of this study was to evaluate the relationship between ACEs and inflammatory profiles (i.e., pro- and anti-) in early childhood and to examine whether patterns differ for racial/ethnic subgroups. Study design: Using longitudinal data from the Multidimensional Assessment of Preschoolers Study (MAPS) (N = 122), we examined the relationship between adverse childhood experiences (ACEs) beginning at birth, C -reactive protein (CRP), and both pro-inflammatory (i.e., IL-1 β, IL-6, TNF, and CRP) and anti-inflammatory (i.e. IL-4 and IL-10) biomarkers during early school age (ages 6–8 years). Results: No children in the sample were reported to have experienced 0 ACES, 7% had 1 ACE, 51% had 2-3 ACEs, and 42% had 4 or more ACEs accumulated by the early school-age wave (ESA). There were no significant associations between cumulative ACEs and inflammatory markers. However, parental substance abuse, a specific ACE, was positively correlated with a pro-inflammatory profile at early school age (r = 0.18, p<.05). Specifically, substance abuse as an ACE was associated with higher levels of pro-inflammatory markers such as IL-1 β and IL-6. Additionally, Hispanics with ACEs had higher levels of CRP than Black and white individuals. Conclusions: Children with histories of ACEs, especially those with parental substance abuse, may have higher levels of inflammation. Better understanding the role of inflammation in the development of chronic diseases for individuals with ACEs may allow earlier identification and prevention of disease during childhood for those at the highest risk. | ||
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700 | 0 | |a Matthew M. Davis |e verfasserin |4 aut | |
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700 | 0 | |a Liliana Aguayo |e verfasserin |4 aut | |
700 | 0 | |a Lauren Wakschlag |e verfasserin |4 aut | |
700 | 0 | |a Frank Penedo |e verfasserin |4 aut | |
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10.1016/j.bbih.2019.100006 doi (DE-627)DOAJ001046977 (DE-599)DOAJ6ee983e9c8834f18ab9b0768513413c8 DE-627 ger DE-627 rakwb eng RC321-571 Nia Heard-Garris verfasserin aut Adverse childhood experiences and biomarkers of inflammation in a diverse cohort of early school-aged children 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: The objective of this study was to evaluate the relationship between ACEs and inflammatory profiles (i.e., pro- and anti-) in early childhood and to examine whether patterns differ for racial/ethnic subgroups. Study design: Using longitudinal data from the Multidimensional Assessment of Preschoolers Study (MAPS) (N = 122), we examined the relationship between adverse childhood experiences (ACEs) beginning at birth, C -reactive protein (CRP), and both pro-inflammatory (i.e., IL-1 β, IL-6, TNF, and CRP) and anti-inflammatory (i.e. IL-4 and IL-10) biomarkers during early school age (ages 6–8 years). Results: No children in the sample were reported to have experienced 0 ACES, 7% had 1 ACE, 51% had 2-3 ACEs, and 42% had 4 or more ACEs accumulated by the early school-age wave (ESA). There were no significant associations between cumulative ACEs and inflammatory markers. However, parental substance abuse, a specific ACE, was positively correlated with a pro-inflammatory profile at early school age (r = 0.18, p<.05). Specifically, substance abuse as an ACE was associated with higher levels of pro-inflammatory markers such as IL-1 β and IL-6. Additionally, Hispanics with ACEs had higher levels of CRP than Black and white individuals. Conclusions: Children with histories of ACEs, especially those with parental substance abuse, may have higher levels of inflammation. Better understanding the role of inflammation in the development of chronic diseases for individuals with ACEs may allow earlier identification and prevention of disease during childhood for those at the highest risk. Inflammation Adverse childhood experiences Young children Neurosciences. Biological psychiatry. Neuropsychiatry Matthew M. Davis verfasserin aut Ryne Estabrook verfasserin aut James Burns verfasserin aut Margaret Briggs-Gowan verfasserin aut Norrina Allen verfasserin aut Mercedes Carnethon verfasserin aut Liliana Aguayo verfasserin aut Lauren Wakschlag verfasserin aut Frank Penedo verfasserin aut In Brain, Behavior, & Immunity - Health Elsevier, 2021 1(2020), Seite 100006- (DE-627)1756567832 26663546 nnns volume:1 year:2020 pages:100006- https://doi.org/10.1016/j.bbih.2019.100006 kostenfrei https://doaj.org/article/6ee983e9c8834f18ab9b0768513413c8 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666354619300067 kostenfrei https://doaj.org/toc/2666-3546 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2020 100006- |
spelling |
10.1016/j.bbih.2019.100006 doi (DE-627)DOAJ001046977 (DE-599)DOAJ6ee983e9c8834f18ab9b0768513413c8 DE-627 ger DE-627 rakwb eng RC321-571 Nia Heard-Garris verfasserin aut Adverse childhood experiences and biomarkers of inflammation in a diverse cohort of early school-aged children 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: The objective of this study was to evaluate the relationship between ACEs and inflammatory profiles (i.e., pro- and anti-) in early childhood and to examine whether patterns differ for racial/ethnic subgroups. Study design: Using longitudinal data from the Multidimensional Assessment of Preschoolers Study (MAPS) (N = 122), we examined the relationship between adverse childhood experiences (ACEs) beginning at birth, C -reactive protein (CRP), and both pro-inflammatory (i.e., IL-1 β, IL-6, TNF, and CRP) and anti-inflammatory (i.e. IL-4 and IL-10) biomarkers during early school age (ages 6–8 years). Results: No children in the sample were reported to have experienced 0 ACES, 7% had 1 ACE, 51% had 2-3 ACEs, and 42% had 4 or more ACEs accumulated by the early school-age wave (ESA). There were no significant associations between cumulative ACEs and inflammatory markers. However, parental substance abuse, a specific ACE, was positively correlated with a pro-inflammatory profile at early school age (r = 0.18, p<.05). Specifically, substance abuse as an ACE was associated with higher levels of pro-inflammatory markers such as IL-1 β and IL-6. Additionally, Hispanics with ACEs had higher levels of CRP than Black and white individuals. Conclusions: Children with histories of ACEs, especially those with parental substance abuse, may have higher levels of inflammation. Better understanding the role of inflammation in the development of chronic diseases for individuals with ACEs may allow earlier identification and prevention of disease during childhood for those at the highest risk. Inflammation Adverse childhood experiences Young children Neurosciences. Biological psychiatry. Neuropsychiatry Matthew M. Davis verfasserin aut Ryne Estabrook verfasserin aut James Burns verfasserin aut Margaret Briggs-Gowan verfasserin aut Norrina Allen verfasserin aut Mercedes Carnethon verfasserin aut Liliana Aguayo verfasserin aut Lauren Wakschlag verfasserin aut Frank Penedo verfasserin aut In Brain, Behavior, & Immunity - Health Elsevier, 2021 1(2020), Seite 100006- (DE-627)1756567832 26663546 nnns volume:1 year:2020 pages:100006- https://doi.org/10.1016/j.bbih.2019.100006 kostenfrei https://doaj.org/article/6ee983e9c8834f18ab9b0768513413c8 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666354619300067 kostenfrei https://doaj.org/toc/2666-3546 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2020 100006- |
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10.1016/j.bbih.2019.100006 doi (DE-627)DOAJ001046977 (DE-599)DOAJ6ee983e9c8834f18ab9b0768513413c8 DE-627 ger DE-627 rakwb eng RC321-571 Nia Heard-Garris verfasserin aut Adverse childhood experiences and biomarkers of inflammation in a diverse cohort of early school-aged children 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: The objective of this study was to evaluate the relationship between ACEs and inflammatory profiles (i.e., pro- and anti-) in early childhood and to examine whether patterns differ for racial/ethnic subgroups. Study design: Using longitudinal data from the Multidimensional Assessment of Preschoolers Study (MAPS) (N = 122), we examined the relationship between adverse childhood experiences (ACEs) beginning at birth, C -reactive protein (CRP), and both pro-inflammatory (i.e., IL-1 β, IL-6, TNF, and CRP) and anti-inflammatory (i.e. IL-4 and IL-10) biomarkers during early school age (ages 6–8 years). Results: No children in the sample were reported to have experienced 0 ACES, 7% had 1 ACE, 51% had 2-3 ACEs, and 42% had 4 or more ACEs accumulated by the early school-age wave (ESA). There were no significant associations between cumulative ACEs and inflammatory markers. However, parental substance abuse, a specific ACE, was positively correlated with a pro-inflammatory profile at early school age (r = 0.18, p<.05). Specifically, substance abuse as an ACE was associated with higher levels of pro-inflammatory markers such as IL-1 β and IL-6. Additionally, Hispanics with ACEs had higher levels of CRP than Black and white individuals. Conclusions: Children with histories of ACEs, especially those with parental substance abuse, may have higher levels of inflammation. Better understanding the role of inflammation in the development of chronic diseases for individuals with ACEs may allow earlier identification and prevention of disease during childhood for those at the highest risk. Inflammation Adverse childhood experiences Young children Neurosciences. Biological psychiatry. Neuropsychiatry Matthew M. Davis verfasserin aut Ryne Estabrook verfasserin aut James Burns verfasserin aut Margaret Briggs-Gowan verfasserin aut Norrina Allen verfasserin aut Mercedes Carnethon verfasserin aut Liliana Aguayo verfasserin aut Lauren Wakschlag verfasserin aut Frank Penedo verfasserin aut In Brain, Behavior, & Immunity - Health Elsevier, 2021 1(2020), Seite 100006- (DE-627)1756567832 26663546 nnns volume:1 year:2020 pages:100006- https://doi.org/10.1016/j.bbih.2019.100006 kostenfrei https://doaj.org/article/6ee983e9c8834f18ab9b0768513413c8 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666354619300067 kostenfrei https://doaj.org/toc/2666-3546 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2020 100006- |
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10.1016/j.bbih.2019.100006 doi (DE-627)DOAJ001046977 (DE-599)DOAJ6ee983e9c8834f18ab9b0768513413c8 DE-627 ger DE-627 rakwb eng RC321-571 Nia Heard-Garris verfasserin aut Adverse childhood experiences and biomarkers of inflammation in a diverse cohort of early school-aged children 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: The objective of this study was to evaluate the relationship between ACEs and inflammatory profiles (i.e., pro- and anti-) in early childhood and to examine whether patterns differ for racial/ethnic subgroups. Study design: Using longitudinal data from the Multidimensional Assessment of Preschoolers Study (MAPS) (N = 122), we examined the relationship between adverse childhood experiences (ACEs) beginning at birth, C -reactive protein (CRP), and both pro-inflammatory (i.e., IL-1 β, IL-6, TNF, and CRP) and anti-inflammatory (i.e. IL-4 and IL-10) biomarkers during early school age (ages 6–8 years). Results: No children in the sample were reported to have experienced 0 ACES, 7% had 1 ACE, 51% had 2-3 ACEs, and 42% had 4 or more ACEs accumulated by the early school-age wave (ESA). There were no significant associations between cumulative ACEs and inflammatory markers. However, parental substance abuse, a specific ACE, was positively correlated with a pro-inflammatory profile at early school age (r = 0.18, p<.05). Specifically, substance abuse as an ACE was associated with higher levels of pro-inflammatory markers such as IL-1 β and IL-6. Additionally, Hispanics with ACEs had higher levels of CRP than Black and white individuals. Conclusions: Children with histories of ACEs, especially those with parental substance abuse, may have higher levels of inflammation. Better understanding the role of inflammation in the development of chronic diseases for individuals with ACEs may allow earlier identification and prevention of disease during childhood for those at the highest risk. Inflammation Adverse childhood experiences Young children Neurosciences. Biological psychiatry. Neuropsychiatry Matthew M. Davis verfasserin aut Ryne Estabrook verfasserin aut James Burns verfasserin aut Margaret Briggs-Gowan verfasserin aut Norrina Allen verfasserin aut Mercedes Carnethon verfasserin aut Liliana Aguayo verfasserin aut Lauren Wakschlag verfasserin aut Frank Penedo verfasserin aut In Brain, Behavior, & Immunity - Health Elsevier, 2021 1(2020), Seite 100006- (DE-627)1756567832 26663546 nnns volume:1 year:2020 pages:100006- https://doi.org/10.1016/j.bbih.2019.100006 kostenfrei https://doaj.org/article/6ee983e9c8834f18ab9b0768513413c8 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666354619300067 kostenfrei https://doaj.org/toc/2666-3546 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2020 100006- |
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10.1016/j.bbih.2019.100006 doi (DE-627)DOAJ001046977 (DE-599)DOAJ6ee983e9c8834f18ab9b0768513413c8 DE-627 ger DE-627 rakwb eng RC321-571 Nia Heard-Garris verfasserin aut Adverse childhood experiences and biomarkers of inflammation in a diverse cohort of early school-aged children 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: The objective of this study was to evaluate the relationship between ACEs and inflammatory profiles (i.e., pro- and anti-) in early childhood and to examine whether patterns differ for racial/ethnic subgroups. Study design: Using longitudinal data from the Multidimensional Assessment of Preschoolers Study (MAPS) (N = 122), we examined the relationship between adverse childhood experiences (ACEs) beginning at birth, C -reactive protein (CRP), and both pro-inflammatory (i.e., IL-1 β, IL-6, TNF, and CRP) and anti-inflammatory (i.e. IL-4 and IL-10) biomarkers during early school age (ages 6–8 years). Results: No children in the sample were reported to have experienced 0 ACES, 7% had 1 ACE, 51% had 2-3 ACEs, and 42% had 4 or more ACEs accumulated by the early school-age wave (ESA). There were no significant associations between cumulative ACEs and inflammatory markers. However, parental substance abuse, a specific ACE, was positively correlated with a pro-inflammatory profile at early school age (r = 0.18, p<.05). Specifically, substance abuse as an ACE was associated with higher levels of pro-inflammatory markers such as IL-1 β and IL-6. Additionally, Hispanics with ACEs had higher levels of CRP than Black and white individuals. Conclusions: Children with histories of ACEs, especially those with parental substance abuse, may have higher levels of inflammation. Better understanding the role of inflammation in the development of chronic diseases for individuals with ACEs may allow earlier identification and prevention of disease during childhood for those at the highest risk. Inflammation Adverse childhood experiences Young children Neurosciences. Biological psychiatry. Neuropsychiatry Matthew M. Davis verfasserin aut Ryne Estabrook verfasserin aut James Burns verfasserin aut Margaret Briggs-Gowan verfasserin aut Norrina Allen verfasserin aut Mercedes Carnethon verfasserin aut Liliana Aguayo verfasserin aut Lauren Wakschlag verfasserin aut Frank Penedo verfasserin aut In Brain, Behavior, & Immunity - Health Elsevier, 2021 1(2020), Seite 100006- (DE-627)1756567832 26663546 nnns volume:1 year:2020 pages:100006- https://doi.org/10.1016/j.bbih.2019.100006 kostenfrei https://doaj.org/article/6ee983e9c8834f18ab9b0768513413c8 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666354619300067 kostenfrei https://doaj.org/toc/2666-3546 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2020 100006- |
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adverse childhood experiences and biomarkers of inflammation in a diverse cohort of early school-aged children |
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Adverse childhood experiences and biomarkers of inflammation in a diverse cohort of early school-aged children |
abstract |
Objective: The objective of this study was to evaluate the relationship between ACEs and inflammatory profiles (i.e., pro- and anti-) in early childhood and to examine whether patterns differ for racial/ethnic subgroups. Study design: Using longitudinal data from the Multidimensional Assessment of Preschoolers Study (MAPS) (N = 122), we examined the relationship between adverse childhood experiences (ACEs) beginning at birth, C -reactive protein (CRP), and both pro-inflammatory (i.e., IL-1 β, IL-6, TNF, and CRP) and anti-inflammatory (i.e. IL-4 and IL-10) biomarkers during early school age (ages 6–8 years). Results: No children in the sample were reported to have experienced 0 ACES, 7% had 1 ACE, 51% had 2-3 ACEs, and 42% had 4 or more ACEs accumulated by the early school-age wave (ESA). There were no significant associations between cumulative ACEs and inflammatory markers. However, parental substance abuse, a specific ACE, was positively correlated with a pro-inflammatory profile at early school age (r = 0.18, p<.05). Specifically, substance abuse as an ACE was associated with higher levels of pro-inflammatory markers such as IL-1 β and IL-6. Additionally, Hispanics with ACEs had higher levels of CRP than Black and white individuals. Conclusions: Children with histories of ACEs, especially those with parental substance abuse, may have higher levels of inflammation. Better understanding the role of inflammation in the development of chronic diseases for individuals with ACEs may allow earlier identification and prevention of disease during childhood for those at the highest risk. |
abstractGer |
Objective: The objective of this study was to evaluate the relationship between ACEs and inflammatory profiles (i.e., pro- and anti-) in early childhood and to examine whether patterns differ for racial/ethnic subgroups. Study design: Using longitudinal data from the Multidimensional Assessment of Preschoolers Study (MAPS) (N = 122), we examined the relationship between adverse childhood experiences (ACEs) beginning at birth, C -reactive protein (CRP), and both pro-inflammatory (i.e., IL-1 β, IL-6, TNF, and CRP) and anti-inflammatory (i.e. IL-4 and IL-10) biomarkers during early school age (ages 6–8 years). Results: No children in the sample were reported to have experienced 0 ACES, 7% had 1 ACE, 51% had 2-3 ACEs, and 42% had 4 or more ACEs accumulated by the early school-age wave (ESA). There were no significant associations between cumulative ACEs and inflammatory markers. However, parental substance abuse, a specific ACE, was positively correlated with a pro-inflammatory profile at early school age (r = 0.18, p<.05). Specifically, substance abuse as an ACE was associated with higher levels of pro-inflammatory markers such as IL-1 β and IL-6. Additionally, Hispanics with ACEs had higher levels of CRP than Black and white individuals. Conclusions: Children with histories of ACEs, especially those with parental substance abuse, may have higher levels of inflammation. Better understanding the role of inflammation in the development of chronic diseases for individuals with ACEs may allow earlier identification and prevention of disease during childhood for those at the highest risk. |
abstract_unstemmed |
Objective: The objective of this study was to evaluate the relationship between ACEs and inflammatory profiles (i.e., pro- and anti-) in early childhood and to examine whether patterns differ for racial/ethnic subgroups. Study design: Using longitudinal data from the Multidimensional Assessment of Preschoolers Study (MAPS) (N = 122), we examined the relationship between adverse childhood experiences (ACEs) beginning at birth, C -reactive protein (CRP), and both pro-inflammatory (i.e., IL-1 β, IL-6, TNF, and CRP) and anti-inflammatory (i.e. IL-4 and IL-10) biomarkers during early school age (ages 6–8 years). Results: No children in the sample were reported to have experienced 0 ACES, 7% had 1 ACE, 51% had 2-3 ACEs, and 42% had 4 or more ACEs accumulated by the early school-age wave (ESA). There were no significant associations between cumulative ACEs and inflammatory markers. However, parental substance abuse, a specific ACE, was positively correlated with a pro-inflammatory profile at early school age (r = 0.18, p<.05). Specifically, substance abuse as an ACE was associated with higher levels of pro-inflammatory markers such as IL-1 β and IL-6. Additionally, Hispanics with ACEs had higher levels of CRP than Black and white individuals. Conclusions: Children with histories of ACEs, especially those with parental substance abuse, may have higher levels of inflammation. Better understanding the role of inflammation in the development of chronic diseases for individuals with ACEs may allow earlier identification and prevention of disease during childhood for those at the highest risk. |
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Adverse childhood experiences and biomarkers of inflammation in a diverse cohort of early school-aged children |
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Study design: Using longitudinal data from the Multidimensional Assessment of Preschoolers Study (MAPS) (N = 122), we examined the relationship between adverse childhood experiences (ACEs) beginning at birth, C -reactive protein (CRP), and both pro-inflammatory (i.e., IL-1 β, IL-6, TNF, and CRP) and anti-inflammatory (i.e. IL-4 and IL-10) biomarkers during early school age (ages 6–8 years). Results: No children in the sample were reported to have experienced 0 ACES, 7% had 1 ACE, 51% had 2-3 ACEs, and 42% had 4 or more ACEs accumulated by the early school-age wave (ESA). There were no significant associations between cumulative ACEs and inflammatory markers. However, parental substance abuse, a specific ACE, was positively correlated with a pro-inflammatory profile at early school age (r = 0.18, p<.05). Specifically, substance abuse as an ACE was associated with higher levels of pro-inflammatory markers such as IL-1 β and IL-6. 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Davis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ryne Estabrook</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">James Burns</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Margaret Briggs-Gowan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Norrina Allen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mercedes Carnethon</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" 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