Effects of Mandibular Extension on Pial Arteriolar Diameter Changes in Glucocorticoid-Induced Hypertensive Rats

Previously, in normotensive rats, it has been observed that a repetitive sub-maximal mouth opening (mandibular extension, ME) obtained by placing a home-made U-shaped dilator between the superior and inferior dental arches of the rat caused modulation of pial arteriolar tone. The present study was a...
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Gespeichert in:

Autor*in:	Dominga Lapi [verfasserIn] Maurizio Varanini [verfasserIn] Lucrezia Galasso [verfasserIn] Martina Di Maro [verfasserIn] Giuseppe Federighi [verfasserIn] Cristina Del Seppia [verfasserIn] Antonio Colantuoni [verfasserIn] Rossana Scuri [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	mandibular extension glucocorticoid-induced hypertension rat pial microcirculation Strahler’s ordering scheme arteriolar rhythmic diameter changes

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 10(2019)
Übergeordnetes Werk:	volume:10 ; year:2019

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2019.00003

Katalog-ID:	DOAJ001382136

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callnumber-first	Q - Science
author	Dominga Lapi
spellingShingle	Dominga Lapi misc QP1-981 misc mandibular extension misc glucocorticoid-induced hypertension misc rat pial microcirculation misc Strahler’s ordering scheme misc arteriolar rhythmic diameter changes misc Physiology Effects of Mandibular Extension on Pial Arteriolar Diameter Changes in Glucocorticoid-Induced Hypertensive Rats
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topic_title	QP1-981 Effects of Mandibular Extension on Pial Arteriolar Diameter Changes in Glucocorticoid-Induced Hypertensive Rats mandibular extension glucocorticoid-induced hypertension rat pial microcirculation Strahler’s ordering scheme arteriolar rhythmic diameter changes
topic	misc QP1-981 misc mandibular extension misc glucocorticoid-induced hypertension misc rat pial microcirculation misc Strahler’s ordering scheme misc arteriolar rhythmic diameter changes misc Physiology
topic_unstemmed	misc QP1-981 misc mandibular extension misc glucocorticoid-induced hypertension misc rat pial microcirculation misc Strahler’s ordering scheme misc arteriolar rhythmic diameter changes misc Physiology
topic_browse	misc QP1-981 misc mandibular extension misc glucocorticoid-induced hypertension misc rat pial microcirculation misc Strahler’s ordering scheme misc arteriolar rhythmic diameter changes misc Physiology
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title	Effects of Mandibular Extension on Pial Arteriolar Diameter Changes in Glucocorticoid-Induced Hypertensive Rats
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title_full	Effects of Mandibular Extension on Pial Arteriolar Diameter Changes in Glucocorticoid-Induced Hypertensive Rats
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author_browse	Dominga Lapi Maurizio Varanini Lucrezia Galasso Martina Di Maro Giuseppe Federighi Cristina Del Seppia Antonio Colantuoni Rossana Scuri
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title_sort	effects of mandibular extension on pial arteriolar diameter changes in glucocorticoid-induced hypertensive rats
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title_auth	Effects of Mandibular Extension on Pial Arteriolar Diameter Changes in Glucocorticoid-Induced Hypertensive Rats
abstract	Previously, in normotensive rats, it has been observed that a repetitive sub-maximal mouth opening (mandibular extension, ME) obtained by placing a home-made U-shaped dilator between the superior and inferior dental arches of the rat caused modulation of pial arteriolar tone. The present study was aimed to characterize pial microcirculation in two different cortical brain regions and to assess the hemodynamic effects of a single or double ME on pial arteriolar rhythmic diameter changes in rats rendered hypertensive by dexamethasone administrations. Cranial windows were prepared on parietal and frontal region. Pial arterioles were classified by Strahler method in five orders by in vivo fluorescence microscopy technique associated with a computerized system that permits off-line measurements of arteriolar diameter changes. Two 10 min ME at 10 min interval were applied; then the animals were monitored for further 240 min. Dexamethasone-treated rats exhibited a marked arterial rarefaction and asymmetry of bifurcation in the pial microvascular networks more evident in the frontal region. Starting from ME1, in both cortical areas, the arterioles dilated, and the vasodilation became significant compared to baseline after ME2 for the entire observation period. The spectral analysis carried out on order 2 arteriolar diameter change tracings, showed that double ME increased the spectral density of the frequency components related to endothelial, neuronal and myogenic activities in both the cortical regions studied. In conclusion, double ME has a generalized effect in the cortical areas by restoring the physiological vasomotion of the pial arterioles that was severely impaired by the experimentally hypertension.
abstractGer	Previously, in normotensive rats, it has been observed that a repetitive sub-maximal mouth opening (mandibular extension, ME) obtained by placing a home-made U-shaped dilator between the superior and inferior dental arches of the rat caused modulation of pial arteriolar tone. The present study was aimed to characterize pial microcirculation in two different cortical brain regions and to assess the hemodynamic effects of a single or double ME on pial arteriolar rhythmic diameter changes in rats rendered hypertensive by dexamethasone administrations. Cranial windows were prepared on parietal and frontal region. Pial arterioles were classified by Strahler method in five orders by in vivo fluorescence microscopy technique associated with a computerized system that permits off-line measurements of arteriolar diameter changes. Two 10 min ME at 10 min interval were applied; then the animals were monitored for further 240 min. Dexamethasone-treated rats exhibited a marked arterial rarefaction and asymmetry of bifurcation in the pial microvascular networks more evident in the frontal region. Starting from ME1, in both cortical areas, the arterioles dilated, and the vasodilation became significant compared to baseline after ME2 for the entire observation period. The spectral analysis carried out on order 2 arteriolar diameter change tracings, showed that double ME increased the spectral density of the frequency components related to endothelial, neuronal and myogenic activities in both the cortical regions studied. In conclusion, double ME has a generalized effect in the cortical areas by restoring the physiological vasomotion of the pial arterioles that was severely impaired by the experimentally hypertension.
abstract_unstemmed	Previously, in normotensive rats, it has been observed that a repetitive sub-maximal mouth opening (mandibular extension, ME) obtained by placing a home-made U-shaped dilator between the superior and inferior dental arches of the rat caused modulation of pial arteriolar tone. The present study was aimed to characterize pial microcirculation in two different cortical brain regions and to assess the hemodynamic effects of a single or double ME on pial arteriolar rhythmic diameter changes in rats rendered hypertensive by dexamethasone administrations. Cranial windows were prepared on parietal and frontal region. Pial arterioles were classified by Strahler method in five orders by in vivo fluorescence microscopy technique associated with a computerized system that permits off-line measurements of arteriolar diameter changes. Two 10 min ME at 10 min interval were applied; then the animals were monitored for further 240 min. Dexamethasone-treated rats exhibited a marked arterial rarefaction and asymmetry of bifurcation in the pial microvascular networks more evident in the frontal region. Starting from ME1, in both cortical areas, the arterioles dilated, and the vasodilation became significant compared to baseline after ME2 for the entire observation period. The spectral analysis carried out on order 2 arteriolar diameter change tracings, showed that double ME increased the spectral density of the frequency components related to endothelial, neuronal and myogenic activities in both the cortical regions studied. In conclusion, double ME has a generalized effect in the cortical areas by restoring the physiological vasomotion of the pial arterioles that was severely impaired by the experimentally hypertension.
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title_short	Effects of Mandibular Extension on Pial Arteriolar Diameter Changes in Glucocorticoid-Induced Hypertensive Rats
url	https://doi.org/10.3389/fphys.2019.00003 https://doaj.org/article/5f2173ae908d46d5b020c50aebb70c46 https://www.frontiersin.org/article/10.3389/fphys.2019.00003/full https://doaj.org/toc/1664-042X
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author2	Maurizio Varanini Lucrezia Galasso Martina Di Maro Giuseppe Federighi Cristina Del Seppia Antonio Colantuoni Rossana Scuri
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The spectral analysis carried out on order 2 arteriolar diameter change tracings, showed that double ME increased the spectral density of the frequency components related to endothelial, neuronal and myogenic activities in both the cortical regions studied. 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Effects of Mandibular Extension on Pial Arteriolar Diameter Changes in Glucocorticoid-Induced Hypertensive Rats

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