Nanosoldiers: A promising strategy to combat triple negative breast cancer

Abstracts: The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of...
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Gespeichert in:

Autor*in:	Akshayya Pawar [verfasserIn] Priyanka Prabhu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Nanoparticles Theranostic Targeted Photothermal therapy Metastasis Triple negative breast cancer

Übergeordnetes Werk:	In: Biomedicine & Pharmacotherapy - Elsevier, 2021, 110(2019), Seite 319-341
Übergeordnetes Werk:	volume:110 ; year:2019 ; pages:319-341

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.biopha.2018.11.122

Katalog-ID:	DOAJ001387197

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allfields	10.1016/j.biopha.2018.11.122 doi (DE-627)DOAJ001387197 (DE-599)DOAJ08630237528d44fcb3613bf3a6bd36d5 DE-627 ger DE-627 rakwb eng RM1-950 Akshayya Pawar verfasserin aut Nanosoldiers: A promising strategy to combat triple negative breast cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstracts: The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents. Nanoparticles Theranostic Targeted Photothermal therapy Metastasis Triple negative breast cancer Therapeutics. Pharmacology Priyanka Prabhu verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 110(2019), Seite 319-341 (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:110 year:2019 pages:319-341 https://doi.org/10.1016/j.biopha.2018.11.122 kostenfrei https://doaj.org/article/08630237528d44fcb3613bf3a6bd36d5 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332218369178 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 110 2019 319-341
spelling	10.1016/j.biopha.2018.11.122 doi (DE-627)DOAJ001387197 (DE-599)DOAJ08630237528d44fcb3613bf3a6bd36d5 DE-627 ger DE-627 rakwb eng RM1-950 Akshayya Pawar verfasserin aut Nanosoldiers: A promising strategy to combat triple negative breast cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstracts: The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents. Nanoparticles Theranostic Targeted Photothermal therapy Metastasis Triple negative breast cancer Therapeutics. Pharmacology Priyanka Prabhu verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 110(2019), Seite 319-341 (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:110 year:2019 pages:319-341 https://doi.org/10.1016/j.biopha.2018.11.122 kostenfrei https://doaj.org/article/08630237528d44fcb3613bf3a6bd36d5 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332218369178 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 110 2019 319-341
allfields_unstemmed	10.1016/j.biopha.2018.11.122 doi (DE-627)DOAJ001387197 (DE-599)DOAJ08630237528d44fcb3613bf3a6bd36d5 DE-627 ger DE-627 rakwb eng RM1-950 Akshayya Pawar verfasserin aut Nanosoldiers: A promising strategy to combat triple negative breast cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstracts: The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents. Nanoparticles Theranostic Targeted Photothermal therapy Metastasis Triple negative breast cancer Therapeutics. Pharmacology Priyanka Prabhu verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 110(2019), Seite 319-341 (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:110 year:2019 pages:319-341 https://doi.org/10.1016/j.biopha.2018.11.122 kostenfrei https://doaj.org/article/08630237528d44fcb3613bf3a6bd36d5 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332218369178 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 110 2019 319-341
allfieldsGer	10.1016/j.biopha.2018.11.122 doi (DE-627)DOAJ001387197 (DE-599)DOAJ08630237528d44fcb3613bf3a6bd36d5 DE-627 ger DE-627 rakwb eng RM1-950 Akshayya Pawar verfasserin aut Nanosoldiers: A promising strategy to combat triple negative breast cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstracts: The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents. Nanoparticles Theranostic Targeted Photothermal therapy Metastasis Triple negative breast cancer Therapeutics. Pharmacology Priyanka Prabhu verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 110(2019), Seite 319-341 (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:110 year:2019 pages:319-341 https://doi.org/10.1016/j.biopha.2018.11.122 kostenfrei https://doaj.org/article/08630237528d44fcb3613bf3a6bd36d5 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332218369178 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 110 2019 319-341
allfieldsSound	10.1016/j.biopha.2018.11.122 doi (DE-627)DOAJ001387197 (DE-599)DOAJ08630237528d44fcb3613bf3a6bd36d5 DE-627 ger DE-627 rakwb eng RM1-950 Akshayya Pawar verfasserin aut Nanosoldiers: A promising strategy to combat triple negative breast cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstracts: The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents. Nanoparticles Theranostic Targeted Photothermal therapy Metastasis Triple negative breast cancer Therapeutics. Pharmacology Priyanka Prabhu verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 110(2019), Seite 319-341 (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:110 year:2019 pages:319-341 https://doi.org/10.1016/j.biopha.2018.11.122 kostenfrei https://doaj.org/article/08630237528d44fcb3613bf3a6bd36d5 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332218369178 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 110 2019 319-341
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title	Nanosoldiers: A promising strategy to combat triple negative breast cancer
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title_full	Nanosoldiers: A promising strategy to combat triple negative breast cancer
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title_sort	nanosoldiers: a promising strategy to combat triple negative breast cancer
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title_auth	Nanosoldiers: A promising strategy to combat triple negative breast cancer
abstract	Abstracts: The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents.
abstractGer	Abstracts: The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents.
abstract_unstemmed	Abstracts: The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents.
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title_short	Nanosoldiers: A promising strategy to combat triple negative breast cancer
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author2Str	Priyanka Prabhu
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callnumber-subject	RM - Therapeutics and Pharmacology
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doi_str	10.1016/j.biopha.2018.11.122
callnumber-a	RM1-950
up_date	2024-07-03T20:07:49.842Z
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