A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study

Abstract Background Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. Results In our study, associations between 4956 GWAS catalog rep...
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Autor*in:	Xueyan Zhao [verfasserIn] Xin Geng [verfasserIn] Vinodh Srinivasasainagendra [verfasserIn] Ninad Chaudhary [verfasserIn] Suzanne Judd [verfasserIn] Virginia Wadley [verfasserIn] Orlando M. Gutiérrez [verfasserIn] Henry Wang [verfasserIn] Ethan M. Lange [verfasserIn] Leslie A. Lange [verfasserIn] Daniel Woo [verfasserIn] Frederick W. Unverzagt [verfasserIn] Monika Safford [verfasserIn] Mary Cushman [verfasserIn] Nita Limdi [verfasserIn] Rakale Quarells [verfasserIn] Donna K. Arnett [verfasserIn] Marguerite R. Irvin [verfasserIn] Degui Zhi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	PheWAS African Americans Genetics Cardiovascular disease

Übergeordnetes Werk:	In: BMC Medical Genomics - BMC, 2008, 12(2019), S1, Seite 167-177
Übergeordnetes Werk:	volume:12 ; year:2019 ; number:S1 ; pages:167-177

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12920-018-0462-7

Katalog-ID:	DOAJ001391941

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allfields	10.1186/s12920-018-0462-7 doi (DE-627)DOAJ001391941 (DE-599)DOAJc088302a394e465981cb5828109e5ca0 DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Xueyan Zhao verfasserin aut A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. Results In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. Conclusion Our cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation. PheWAS African Americans Genetics Cardiovascular disease Internal medicine Xin Geng verfasserin aut Vinodh Srinivasasainagendra verfasserin aut Ninad Chaudhary verfasserin aut Suzanne Judd verfasserin aut Virginia Wadley verfasserin aut Orlando M. Gutiérrez verfasserin aut Henry Wang verfasserin aut Ethan M. Lange verfasserin aut Leslie A. Lange verfasserin aut Daniel Woo verfasserin aut Frederick W. Unverzagt verfasserin aut Monika Safford verfasserin aut Mary Cushman verfasserin aut Nita Limdi verfasserin aut Rakale Quarells verfasserin aut Donna K. Arnett verfasserin aut Marguerite R. Irvin verfasserin aut Degui Zhi verfasserin aut In BMC Medical Genomics BMC, 2008 12(2019), S1, Seite 167-177 (DE-627)559080824 (DE-600)2411865-5 17558794 nnns volume:12 year:2019 number:S1 pages:167-177 https://doi.org/10.1186/s12920-018-0462-7 kostenfrei https://doaj.org/article/c088302a394e465981cb5828109e5ca0 kostenfrei http://link.springer.com/article/10.1186/s12920-018-0462-7 kostenfrei https://doaj.org/toc/1755-8794 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 S1 167-177
spelling	10.1186/s12920-018-0462-7 doi (DE-627)DOAJ001391941 (DE-599)DOAJc088302a394e465981cb5828109e5ca0 DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Xueyan Zhao verfasserin aut A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. Results In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. Conclusion Our cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation. PheWAS African Americans Genetics Cardiovascular disease Internal medicine Xin Geng verfasserin aut Vinodh Srinivasasainagendra verfasserin aut Ninad Chaudhary verfasserin aut Suzanne Judd verfasserin aut Virginia Wadley verfasserin aut Orlando M. Gutiérrez verfasserin aut Henry Wang verfasserin aut Ethan M. Lange verfasserin aut Leslie A. Lange verfasserin aut Daniel Woo verfasserin aut Frederick W. Unverzagt verfasserin aut Monika Safford verfasserin aut Mary Cushman verfasserin aut Nita Limdi verfasserin aut Rakale Quarells verfasserin aut Donna K. Arnett verfasserin aut Marguerite R. Irvin verfasserin aut Degui Zhi verfasserin aut In BMC Medical Genomics BMC, 2008 12(2019), S1, Seite 167-177 (DE-627)559080824 (DE-600)2411865-5 17558794 nnns volume:12 year:2019 number:S1 pages:167-177 https://doi.org/10.1186/s12920-018-0462-7 kostenfrei https://doaj.org/article/c088302a394e465981cb5828109e5ca0 kostenfrei http://link.springer.com/article/10.1186/s12920-018-0462-7 kostenfrei https://doaj.org/toc/1755-8794 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 S1 167-177
allfields_unstemmed	10.1186/s12920-018-0462-7 doi (DE-627)DOAJ001391941 (DE-599)DOAJc088302a394e465981cb5828109e5ca0 DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Xueyan Zhao verfasserin aut A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. Results In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. Conclusion Our cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation. PheWAS African Americans Genetics Cardiovascular disease Internal medicine Xin Geng verfasserin aut Vinodh Srinivasasainagendra verfasserin aut Ninad Chaudhary verfasserin aut Suzanne Judd verfasserin aut Virginia Wadley verfasserin aut Orlando M. Gutiérrez verfasserin aut Henry Wang verfasserin aut Ethan M. Lange verfasserin aut Leslie A. Lange verfasserin aut Daniel Woo verfasserin aut Frederick W. Unverzagt verfasserin aut Monika Safford verfasserin aut Mary Cushman verfasserin aut Nita Limdi verfasserin aut Rakale Quarells verfasserin aut Donna K. Arnett verfasserin aut Marguerite R. Irvin verfasserin aut Degui Zhi verfasserin aut In BMC Medical Genomics BMC, 2008 12(2019), S1, Seite 167-177 (DE-627)559080824 (DE-600)2411865-5 17558794 nnns volume:12 year:2019 number:S1 pages:167-177 https://doi.org/10.1186/s12920-018-0462-7 kostenfrei https://doaj.org/article/c088302a394e465981cb5828109e5ca0 kostenfrei http://link.springer.com/article/10.1186/s12920-018-0462-7 kostenfrei https://doaj.org/toc/1755-8794 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 S1 167-177
allfieldsGer	10.1186/s12920-018-0462-7 doi (DE-627)DOAJ001391941 (DE-599)DOAJc088302a394e465981cb5828109e5ca0 DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Xueyan Zhao verfasserin aut A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. Results In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. Conclusion Our cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation. PheWAS African Americans Genetics Cardiovascular disease Internal medicine Xin Geng verfasserin aut Vinodh Srinivasasainagendra verfasserin aut Ninad Chaudhary verfasserin aut Suzanne Judd verfasserin aut Virginia Wadley verfasserin aut Orlando M. Gutiérrez verfasserin aut Henry Wang verfasserin aut Ethan M. Lange verfasserin aut Leslie A. Lange verfasserin aut Daniel Woo verfasserin aut Frederick W. Unverzagt verfasserin aut Monika Safford verfasserin aut Mary Cushman verfasserin aut Nita Limdi verfasserin aut Rakale Quarells verfasserin aut Donna K. Arnett verfasserin aut Marguerite R. Irvin verfasserin aut Degui Zhi verfasserin aut In BMC Medical Genomics BMC, 2008 12(2019), S1, Seite 167-177 (DE-627)559080824 (DE-600)2411865-5 17558794 nnns volume:12 year:2019 number:S1 pages:167-177 https://doi.org/10.1186/s12920-018-0462-7 kostenfrei https://doaj.org/article/c088302a394e465981cb5828109e5ca0 kostenfrei http://link.springer.com/article/10.1186/s12920-018-0462-7 kostenfrei https://doaj.org/toc/1755-8794 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 S1 167-177
allfieldsSound	10.1186/s12920-018-0462-7 doi (DE-627)DOAJ001391941 (DE-599)DOAJc088302a394e465981cb5828109e5ca0 DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Xueyan Zhao verfasserin aut A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. Results In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. Conclusion Our cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation. PheWAS African Americans Genetics Cardiovascular disease Internal medicine Xin Geng verfasserin aut Vinodh Srinivasasainagendra verfasserin aut Ninad Chaudhary verfasserin aut Suzanne Judd verfasserin aut Virginia Wadley verfasserin aut Orlando M. Gutiérrez verfasserin aut Henry Wang verfasserin aut Ethan M. Lange verfasserin aut Leslie A. Lange verfasserin aut Daniel Woo verfasserin aut Frederick W. Unverzagt verfasserin aut Monika Safford verfasserin aut Mary Cushman verfasserin aut Nita Limdi verfasserin aut Rakale Quarells verfasserin aut Donna K. Arnett verfasserin aut Marguerite R. Irvin verfasserin aut Degui Zhi verfasserin aut In BMC Medical Genomics BMC, 2008 12(2019), S1, Seite 167-177 (DE-627)559080824 (DE-600)2411865-5 17558794 nnns volume:12 year:2019 number:S1 pages:167-177 https://doi.org/10.1186/s12920-018-0462-7 kostenfrei https://doaj.org/article/c088302a394e465981cb5828109e5ca0 kostenfrei http://link.springer.com/article/10.1186/s12920-018-0462-7 kostenfrei https://doaj.org/toc/1755-8794 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 S1 167-177
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callnumber-first	R - Medicine
author	Xueyan Zhao
spellingShingle	Xueyan Zhao misc RC31-1245 misc QH426-470 misc PheWAS misc African Americans misc Genetics misc Cardiovascular disease misc Internal medicine A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study
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topic_title	RC31-1245 QH426-470 A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study PheWAS African Americans Genetics Cardiovascular disease
topic	misc RC31-1245 misc QH426-470 misc PheWAS misc African Americans misc Genetics misc Cardiovascular disease misc Internal medicine
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title_full	A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study
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author_browse	Xueyan Zhao Xin Geng Vinodh Srinivasasainagendra Ninad Chaudhary Suzanne Judd Virginia Wadley Orlando M. Gutiérrez Henry Wang Ethan M. Lange Leslie A. Lange Daniel Woo Frederick W. Unverzagt Monika Safford Mary Cushman Nita Limdi Rakale Quarells Donna K. Arnett Marguerite R. Irvin Degui Zhi
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title_sort	phewas study of a large observational epidemiological cohort of african americans from the regards study
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title_auth	A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study
abstract	Abstract Background Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. Results In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. Conclusion Our cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation.
abstractGer	Abstract Background Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. Results In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. Conclusion Our cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation.
abstract_unstemmed	Abstract Background Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. Results In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. Conclusion Our cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation.
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title_short	A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study
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author2	Xin Geng Vinodh Srinivasasainagendra Ninad Chaudhary Suzanne Judd Virginia Wadley Orlando M. Gutiérrez Henry Wang Ethan M. Lange Leslie A. Lange Daniel Woo Frederick W. Unverzagt Monika Safford Mary Cushman Nita Limdi Rakale Quarells Donna K. Arnett Marguerite R. Irvin Degui Zhi
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However, knowledge of genetic determinants of those diseases in African Americans remains limited. Results In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. 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A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study

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