Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells

A definitive cure for chronic myeloid leukemia (CML) requires identifying novel therapeutic targets to eradicate leukemia stem cells (LSCs). However, the rarity of LSCs within the primitive hematopoietic cell compartment remains a major limiting factor for their study in humans. Here we show that pr...
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Autor*in:	Kran Suknuntha [verfasserIn] Yuki Ishii [verfasserIn] Lihong Tao [verfasserIn] Kejin Hu [verfasserIn] Brian E. McIntosh [verfasserIn] David Yang [verfasserIn] Scott Swanson [verfasserIn] Ron Stewart [verfasserIn] Jean Y.J. Wang [verfasserIn] James Thomson [verfasserIn] Igor Slukvin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Übergeordnetes Werk:	In: Stem Cell Research - Elsevier, 2015, 15(2015), 3, Seite 678-693
Übergeordnetes Werk:	volume:15 ; year:2015 ; number:3 ; pages:678-693

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1016/j.scr.2015.10.015

Katalog-ID:	DOAJ001508334

Internformat


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520			\|a A definitive cure for chronic myeloid leukemia (CML) requires identifying novel therapeutic targets to eradicate leukemia stem cells (LSCs). However, the rarity of LSCs within the primitive hematopoietic cell compartment remains a major limiting factor for their study in humans. Here we show that primitive hematopoietic cells with typical LSC features, including adhesion defect, increased long-term survival and proliferation, and innate resistance to tyrosine kinase inhibitor (TKI) imatinib, can be generated de novo from reprogrammed primary CML cells. Using CML iPSC-derived primitive leukemia cells, we discovered olfactomedin 4 (OLFM4) as a novel factor that contributes to survival and growth of somatic lin−CD34+ cells from bone marrow of patients with CML in chronic phase, but not primitive hematopoietic cells from normal bone marrow. Overall, this study shows the feasibility and advantages of using reprogramming technology to develop strategies for targeting primitive leukemia cells.
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700	0		\|a David Yang \|e verfasserin \|4 aut
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700	0		\|a Ron Stewart \|e verfasserin \|4 aut
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700	0		\|a James Thomson \|e verfasserin \|4 aut
700	0		\|a Igor Slukvin \|e verfasserin \|4 aut
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allfields	10.1016/j.scr.2015.10.015 doi (DE-627)DOAJ001508334 (DE-599)DOAJdb89078e73f04cb0afedee556e8fb2bd DE-627 ger DE-627 rakwb eng QH301-705.5 Kran Suknuntha verfasserin aut Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A definitive cure for chronic myeloid leukemia (CML) requires identifying novel therapeutic targets to eradicate leukemia stem cells (LSCs). However, the rarity of LSCs within the primitive hematopoietic cell compartment remains a major limiting factor for their study in humans. Here we show that primitive hematopoietic cells with typical LSC features, including adhesion defect, increased long-term survival and proliferation, and innate resistance to tyrosine kinase inhibitor (TKI) imatinib, can be generated de novo from reprogrammed primary CML cells. Using CML iPSC-derived primitive leukemia cells, we discovered olfactomedin 4 (OLFM4) as a novel factor that contributes to survival and growth of somatic lin−CD34+ cells from bone marrow of patients with CML in chronic phase, but not primitive hematopoietic cells from normal bone marrow. Overall, this study shows the feasibility and advantages of using reprogramming technology to develop strategies for targeting primitive leukemia cells. Biology (General) Yuki Ishii verfasserin aut Lihong Tao verfasserin aut Kejin Hu verfasserin aut Brian E. McIntosh verfasserin aut David Yang verfasserin aut Scott Swanson verfasserin aut Ron Stewart verfasserin aut Jean Y.J. Wang verfasserin aut James Thomson verfasserin aut Igor Slukvin verfasserin aut In Stem Cell Research Elsevier, 2015 15(2015), 3, Seite 678-693 (DE-627)548125856 (DE-600)2393143-7 18767753 nnns volume:15 year:2015 number:3 pages:678-693 https://doi.org/10.1016/j.scr.2015.10.015 kostenfrei https://doaj.org/article/db89078e73f04cb0afedee556e8fb2bd kostenfrei http://www.sciencedirect.com/science/article/pii/S1873506115001506 kostenfrei https://doaj.org/toc/1873-5061 Journal toc kostenfrei https://doaj.org/toc/1876-7753 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 15 2015 3 678-693
spelling	10.1016/j.scr.2015.10.015 doi (DE-627)DOAJ001508334 (DE-599)DOAJdb89078e73f04cb0afedee556e8fb2bd DE-627 ger DE-627 rakwb eng QH301-705.5 Kran Suknuntha verfasserin aut Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A definitive cure for chronic myeloid leukemia (CML) requires identifying novel therapeutic targets to eradicate leukemia stem cells (LSCs). However, the rarity of LSCs within the primitive hematopoietic cell compartment remains a major limiting factor for their study in humans. Here we show that primitive hematopoietic cells with typical LSC features, including adhesion defect, increased long-term survival and proliferation, and innate resistance to tyrosine kinase inhibitor (TKI) imatinib, can be generated de novo from reprogrammed primary CML cells. Using CML iPSC-derived primitive leukemia cells, we discovered olfactomedin 4 (OLFM4) as a novel factor that contributes to survival and growth of somatic lin−CD34+ cells from bone marrow of patients with CML in chronic phase, but not primitive hematopoietic cells from normal bone marrow. Overall, this study shows the feasibility and advantages of using reprogramming technology to develop strategies for targeting primitive leukemia cells. Biology (General) Yuki Ishii verfasserin aut Lihong Tao verfasserin aut Kejin Hu verfasserin aut Brian E. McIntosh verfasserin aut David Yang verfasserin aut Scott Swanson verfasserin aut Ron Stewart verfasserin aut Jean Y.J. Wang verfasserin aut James Thomson verfasserin aut Igor Slukvin verfasserin aut In Stem Cell Research Elsevier, 2015 15(2015), 3, Seite 678-693 (DE-627)548125856 (DE-600)2393143-7 18767753 nnns volume:15 year:2015 number:3 pages:678-693 https://doi.org/10.1016/j.scr.2015.10.015 kostenfrei https://doaj.org/article/db89078e73f04cb0afedee556e8fb2bd kostenfrei http://www.sciencedirect.com/science/article/pii/S1873506115001506 kostenfrei https://doaj.org/toc/1873-5061 Journal toc kostenfrei https://doaj.org/toc/1876-7753 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 15 2015 3 678-693
allfields_unstemmed	10.1016/j.scr.2015.10.015 doi (DE-627)DOAJ001508334 (DE-599)DOAJdb89078e73f04cb0afedee556e8fb2bd DE-627 ger DE-627 rakwb eng QH301-705.5 Kran Suknuntha verfasserin aut Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A definitive cure for chronic myeloid leukemia (CML) requires identifying novel therapeutic targets to eradicate leukemia stem cells (LSCs). However, the rarity of LSCs within the primitive hematopoietic cell compartment remains a major limiting factor for their study in humans. Here we show that primitive hematopoietic cells with typical LSC features, including adhesion defect, increased long-term survival and proliferation, and innate resistance to tyrosine kinase inhibitor (TKI) imatinib, can be generated de novo from reprogrammed primary CML cells. Using CML iPSC-derived primitive leukemia cells, we discovered olfactomedin 4 (OLFM4) as a novel factor that contributes to survival and growth of somatic lin−CD34+ cells from bone marrow of patients with CML in chronic phase, but not primitive hematopoietic cells from normal bone marrow. Overall, this study shows the feasibility and advantages of using reprogramming technology to develop strategies for targeting primitive leukemia cells. Biology (General) Yuki Ishii verfasserin aut Lihong Tao verfasserin aut Kejin Hu verfasserin aut Brian E. McIntosh verfasserin aut David Yang verfasserin aut Scott Swanson verfasserin aut Ron Stewart verfasserin aut Jean Y.J. Wang verfasserin aut James Thomson verfasserin aut Igor Slukvin verfasserin aut In Stem Cell Research Elsevier, 2015 15(2015), 3, Seite 678-693 (DE-627)548125856 (DE-600)2393143-7 18767753 nnns volume:15 year:2015 number:3 pages:678-693 https://doi.org/10.1016/j.scr.2015.10.015 kostenfrei https://doaj.org/article/db89078e73f04cb0afedee556e8fb2bd kostenfrei http://www.sciencedirect.com/science/article/pii/S1873506115001506 kostenfrei https://doaj.org/toc/1873-5061 Journal toc kostenfrei https://doaj.org/toc/1876-7753 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 15 2015 3 678-693
allfieldsGer	10.1016/j.scr.2015.10.015 doi (DE-627)DOAJ001508334 (DE-599)DOAJdb89078e73f04cb0afedee556e8fb2bd DE-627 ger DE-627 rakwb eng QH301-705.5 Kran Suknuntha verfasserin aut Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A definitive cure for chronic myeloid leukemia (CML) requires identifying novel therapeutic targets to eradicate leukemia stem cells (LSCs). However, the rarity of LSCs within the primitive hematopoietic cell compartment remains a major limiting factor for their study in humans. Here we show that primitive hematopoietic cells with typical LSC features, including adhesion defect, increased long-term survival and proliferation, and innate resistance to tyrosine kinase inhibitor (TKI) imatinib, can be generated de novo from reprogrammed primary CML cells. Using CML iPSC-derived primitive leukemia cells, we discovered olfactomedin 4 (OLFM4) as a novel factor that contributes to survival and growth of somatic lin−CD34+ cells from bone marrow of patients with CML in chronic phase, but not primitive hematopoietic cells from normal bone marrow. Overall, this study shows the feasibility and advantages of using reprogramming technology to develop strategies for targeting primitive leukemia cells. Biology (General) Yuki Ishii verfasserin aut Lihong Tao verfasserin aut Kejin Hu verfasserin aut Brian E. McIntosh verfasserin aut David Yang verfasserin aut Scott Swanson verfasserin aut Ron Stewart verfasserin aut Jean Y.J. Wang verfasserin aut James Thomson verfasserin aut Igor Slukvin verfasserin aut In Stem Cell Research Elsevier, 2015 15(2015), 3, Seite 678-693 (DE-627)548125856 (DE-600)2393143-7 18767753 nnns volume:15 year:2015 number:3 pages:678-693 https://doi.org/10.1016/j.scr.2015.10.015 kostenfrei https://doaj.org/article/db89078e73f04cb0afedee556e8fb2bd kostenfrei http://www.sciencedirect.com/science/article/pii/S1873506115001506 kostenfrei https://doaj.org/toc/1873-5061 Journal toc kostenfrei https://doaj.org/toc/1876-7753 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 15 2015 3 678-693
allfieldsSound	10.1016/j.scr.2015.10.015 doi (DE-627)DOAJ001508334 (DE-599)DOAJdb89078e73f04cb0afedee556e8fb2bd DE-627 ger DE-627 rakwb eng QH301-705.5 Kran Suknuntha verfasserin aut Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A definitive cure for chronic myeloid leukemia (CML) requires identifying novel therapeutic targets to eradicate leukemia stem cells (LSCs). However, the rarity of LSCs within the primitive hematopoietic cell compartment remains a major limiting factor for their study in humans. Here we show that primitive hematopoietic cells with typical LSC features, including adhesion defect, increased long-term survival and proliferation, and innate resistance to tyrosine kinase inhibitor (TKI) imatinib, can be generated de novo from reprogrammed primary CML cells. Using CML iPSC-derived primitive leukemia cells, we discovered olfactomedin 4 (OLFM4) as a novel factor that contributes to survival and growth of somatic lin−CD34+ cells from bone marrow of patients with CML in chronic phase, but not primitive hematopoietic cells from normal bone marrow. Overall, this study shows the feasibility and advantages of using reprogramming technology to develop strategies for targeting primitive leukemia cells. Biology (General) Yuki Ishii verfasserin aut Lihong Tao verfasserin aut Kejin Hu verfasserin aut Brian E. McIntosh verfasserin aut David Yang verfasserin aut Scott Swanson verfasserin aut Ron Stewart verfasserin aut Jean Y.J. Wang verfasserin aut James Thomson verfasserin aut Igor Slukvin verfasserin aut In Stem Cell Research Elsevier, 2015 15(2015), 3, Seite 678-693 (DE-627)548125856 (DE-600)2393143-7 18767753 nnns volume:15 year:2015 number:3 pages:678-693 https://doi.org/10.1016/j.scr.2015.10.015 kostenfrei https://doaj.org/article/db89078e73f04cb0afedee556e8fb2bd kostenfrei http://www.sciencedirect.com/science/article/pii/S1873506115001506 kostenfrei https://doaj.org/toc/1873-5061 Journal toc kostenfrei https://doaj.org/toc/1876-7753 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 15 2015 3 678-693
language	English
source	In Stem Cell Research 15(2015), 3, Seite 678-693 volume:15 year:2015 number:3 pages:678-693
sourceStr	In Stem Cell Research 15(2015), 3, Seite 678-693 volume:15 year:2015 number:3 pages:678-693
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Biology (General)
isfreeaccess_bool	true
container_title	Stem Cell Research
authorswithroles_txt_mv	Kran Suknuntha @@aut@@ Yuki Ishii @@aut@@ Lihong Tao @@aut@@ Kejin Hu @@aut@@ Brian E. McIntosh @@aut@@ David Yang @@aut@@ Scott Swanson @@aut@@ Ron Stewart @@aut@@ Jean Y.J. Wang @@aut@@ James Thomson @@aut@@ Igor Slukvin @@aut@@
publishDateDaySort_date	2015-01-01T00:00:00Z
hierarchy_top_id	548125856
id	DOAJ001508334
language_de	englisch
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callnumber-first	Q - Science
author	Kran Suknuntha
spellingShingle	Kran Suknuntha misc QH301-705.5 misc Biology (General) Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells
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topic_title	QH301-705.5 Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells
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title	Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells
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title_full	Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells
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author_browse	Kran Suknuntha Yuki Ishii Lihong Tao Kejin Hu Brian E. McIntosh David Yang Scott Swanson Ron Stewart Jean Y.J. Wang James Thomson Igor Slukvin
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title_sort	discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells
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title_auth	Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells
abstract	A definitive cure for chronic myeloid leukemia (CML) requires identifying novel therapeutic targets to eradicate leukemia stem cells (LSCs). However, the rarity of LSCs within the primitive hematopoietic cell compartment remains a major limiting factor for their study in humans. Here we show that primitive hematopoietic cells with typical LSC features, including adhesion defect, increased long-term survival and proliferation, and innate resistance to tyrosine kinase inhibitor (TKI) imatinib, can be generated de novo from reprogrammed primary CML cells. Using CML iPSC-derived primitive leukemia cells, we discovered olfactomedin 4 (OLFM4) as a novel factor that contributes to survival and growth of somatic lin−CD34+ cells from bone marrow of patients with CML in chronic phase, but not primitive hematopoietic cells from normal bone marrow. Overall, this study shows the feasibility and advantages of using reprogramming technology to develop strategies for targeting primitive leukemia cells.
abstractGer	A definitive cure for chronic myeloid leukemia (CML) requires identifying novel therapeutic targets to eradicate leukemia stem cells (LSCs). However, the rarity of LSCs within the primitive hematopoietic cell compartment remains a major limiting factor for their study in humans. Here we show that primitive hematopoietic cells with typical LSC features, including adhesion defect, increased long-term survival and proliferation, and innate resistance to tyrosine kinase inhibitor (TKI) imatinib, can be generated de novo from reprogrammed primary CML cells. Using CML iPSC-derived primitive leukemia cells, we discovered olfactomedin 4 (OLFM4) as a novel factor that contributes to survival and growth of somatic lin−CD34+ cells from bone marrow of patients with CML in chronic phase, but not primitive hematopoietic cells from normal bone marrow. Overall, this study shows the feasibility and advantages of using reprogramming technology to develop strategies for targeting primitive leukemia cells.
abstract_unstemmed	A definitive cure for chronic myeloid leukemia (CML) requires identifying novel therapeutic targets to eradicate leukemia stem cells (LSCs). However, the rarity of LSCs within the primitive hematopoietic cell compartment remains a major limiting factor for their study in humans. Here we show that primitive hematopoietic cells with typical LSC features, including adhesion defect, increased long-term survival and proliferation, and innate resistance to tyrosine kinase inhibitor (TKI) imatinib, can be generated de novo from reprogrammed primary CML cells. Using CML iPSC-derived primitive leukemia cells, we discovered olfactomedin 4 (OLFM4) as a novel factor that contributes to survival and growth of somatic lin−CD34+ cells from bone marrow of patients with CML in chronic phase, but not primitive hematopoietic cells from normal bone marrow. Overall, this study shows the feasibility and advantages of using reprogramming technology to develop strategies for targeting primitive leukemia cells.
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title_short	Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells
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up_date	2024-07-03T20:51:15.159Z
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Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells

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