Anti-inflammatory effect of water extracts obtained from doenjang in LPS-stimulated RAW 264.7 cells
Abstract The effect of water extracts of doenjang (WED) on cyclooxygenase pathway and cytokine production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells was investigated. WED was fractionated by ultrafiltration into five individual groups of molecular weights. All of the WED fraction...
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Sang Hyun LEE [verfasserIn] Hyesook LEE [verfasserIn] Jae Cherl KIM [verfasserIn] |
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E-Artikel |
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Englisch |
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In: Food Science and Technology - Sociedade Brasileira de Ciência e Tecnologia de Alimentos, 2004 |
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| DOI / URN: |
10.1590/fst.15918 |
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DOAJ001578413 |
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| 520 | |a Abstract The effect of water extracts of doenjang (WED) on cyclooxygenase pathway and cytokine production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells was investigated. WED was fractionated by ultrafiltration into five individual groups of molecular weights. All of the WED fractions significantly inhibited the production of prostaglandin E2 (PGE2) and expression of cyclooxygenase-2 (COX-2) in LPS-stimulated RAW 264.7 macrophages. Furthermore, each of the WED fractions significantly decreased production of pro-inflammatory cytokine such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) (p<0.05). The fraction between 10 to 30 kDa of WED showed the highest inhibition of pro-inflammatory cytokine production, LPS-induced COX-2 expression and PEG2 production. These results suggest that WED fractions may have the anti-inflammatory effect via the stimulus of COX-2 and TNF-α in LPS-stimulated inflammation in RAW 264.7 cells. | ||
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10.1590/fst.15918 doi (DE-627)DOAJ001578413 (DE-599)DOAJe91bc9faed5847958f931c5fefd71088 DE-627 ger DE-627 rakwb eng TX341-641 T1-995 Sang Hyun LEE verfasserin aut Anti-inflammatory effect of water extracts obtained from doenjang in LPS-stimulated RAW 264.7 cells Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The effect of water extracts of doenjang (WED) on cyclooxygenase pathway and cytokine production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells was investigated. WED was fractionated by ultrafiltration into five individual groups of molecular weights. All of the WED fractions significantly inhibited the production of prostaglandin E2 (PGE2) and expression of cyclooxygenase-2 (COX-2) in LPS-stimulated RAW 264.7 macrophages. Furthermore, each of the WED fractions significantly decreased production of pro-inflammatory cytokine such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) (p<0.05). The fraction between 10 to 30 kDa of WED showed the highest inhibition of pro-inflammatory cytokine production, LPS-induced COX-2 expression and PEG2 production. These results suggest that WED fractions may have the anti-inflammatory effect via the stimulus of COX-2 and TNF-α in LPS-stimulated inflammation in RAW 264.7 cells. water extracts of doenjang (WED) fermented soybean paste oxidative stress inflammation Lipopolysaccharide Nutrition. Foods and food supply Technology (General) Hyesook LEE verfasserin aut Jae Cherl KIM verfasserin aut In Food Science and Technology Sociedade Brasileira de Ciência e Tecnologia de Alimentos, 2004 (DE-627)32056780X (DE-600)2016150-5 1678457X nnns https://doi.org/10.1590/fst.15918 kostenfrei https://doaj.org/article/e91bc9faed5847958f931c5fefd71088 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612019005014101&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-457X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/fst.15918 doi (DE-627)DOAJ001578413 (DE-599)DOAJe91bc9faed5847958f931c5fefd71088 DE-627 ger DE-627 rakwb eng TX341-641 T1-995 Sang Hyun LEE verfasserin aut Anti-inflammatory effect of water extracts obtained from doenjang in LPS-stimulated RAW 264.7 cells Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The effect of water extracts of doenjang (WED) on cyclooxygenase pathway and cytokine production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells was investigated. WED was fractionated by ultrafiltration into five individual groups of molecular weights. All of the WED fractions significantly inhibited the production of prostaglandin E2 (PGE2) and expression of cyclooxygenase-2 (COX-2) in LPS-stimulated RAW 264.7 macrophages. Furthermore, each of the WED fractions significantly decreased production of pro-inflammatory cytokine such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) (p<0.05). The fraction between 10 to 30 kDa of WED showed the highest inhibition of pro-inflammatory cytokine production, LPS-induced COX-2 expression and PEG2 production. These results suggest that WED fractions may have the anti-inflammatory effect via the stimulus of COX-2 and TNF-α in LPS-stimulated inflammation in RAW 264.7 cells. water extracts of doenjang (WED) fermented soybean paste oxidative stress inflammation Lipopolysaccharide Nutrition. Foods and food supply Technology (General) Hyesook LEE verfasserin aut Jae Cherl KIM verfasserin aut In Food Science and Technology Sociedade Brasileira de Ciência e Tecnologia de Alimentos, 2004 (DE-627)32056780X (DE-600)2016150-5 1678457X nnns https://doi.org/10.1590/fst.15918 kostenfrei https://doaj.org/article/e91bc9faed5847958f931c5fefd71088 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612019005014101&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-457X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/fst.15918 doi (DE-627)DOAJ001578413 (DE-599)DOAJe91bc9faed5847958f931c5fefd71088 DE-627 ger DE-627 rakwb eng TX341-641 T1-995 Sang Hyun LEE verfasserin aut Anti-inflammatory effect of water extracts obtained from doenjang in LPS-stimulated RAW 264.7 cells Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The effect of water extracts of doenjang (WED) on cyclooxygenase pathway and cytokine production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells was investigated. WED was fractionated by ultrafiltration into five individual groups of molecular weights. All of the WED fractions significantly inhibited the production of prostaglandin E2 (PGE2) and expression of cyclooxygenase-2 (COX-2) in LPS-stimulated RAW 264.7 macrophages. Furthermore, each of the WED fractions significantly decreased production of pro-inflammatory cytokine such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) (p<0.05). The fraction between 10 to 30 kDa of WED showed the highest inhibition of pro-inflammatory cytokine production, LPS-induced COX-2 expression and PEG2 production. These results suggest that WED fractions may have the anti-inflammatory effect via the stimulus of COX-2 and TNF-α in LPS-stimulated inflammation in RAW 264.7 cells. water extracts of doenjang (WED) fermented soybean paste oxidative stress inflammation Lipopolysaccharide Nutrition. Foods and food supply Technology (General) Hyesook LEE verfasserin aut Jae Cherl KIM verfasserin aut In Food Science and Technology Sociedade Brasileira de Ciência e Tecnologia de Alimentos, 2004 (DE-627)32056780X (DE-600)2016150-5 1678457X nnns https://doi.org/10.1590/fst.15918 kostenfrei https://doaj.org/article/e91bc9faed5847958f931c5fefd71088 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612019005014101&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-457X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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Anti-inflammatory effect of water extracts obtained from doenjang in LPS-stimulated RAW 264.7 cells |
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Abstract The effect of water extracts of doenjang (WED) on cyclooxygenase pathway and cytokine production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells was investigated. WED was fractionated by ultrafiltration into five individual groups of molecular weights. All of the WED fractions significantly inhibited the production of prostaglandin E2 (PGE2) and expression of cyclooxygenase-2 (COX-2) in LPS-stimulated RAW 264.7 macrophages. Furthermore, each of the WED fractions significantly decreased production of pro-inflammatory cytokine such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) (p<0.05). The fraction between 10 to 30 kDa of WED showed the highest inhibition of pro-inflammatory cytokine production, LPS-induced COX-2 expression and PEG2 production. These results suggest that WED fractions may have the anti-inflammatory effect via the stimulus of COX-2 and TNF-α in LPS-stimulated inflammation in RAW 264.7 cells. |
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Abstract The effect of water extracts of doenjang (WED) on cyclooxygenase pathway and cytokine production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells was investigated. WED was fractionated by ultrafiltration into five individual groups of molecular weights. All of the WED fractions significantly inhibited the production of prostaglandin E2 (PGE2) and expression of cyclooxygenase-2 (COX-2) in LPS-stimulated RAW 264.7 macrophages. Furthermore, each of the WED fractions significantly decreased production of pro-inflammatory cytokine such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) (p<0.05). The fraction between 10 to 30 kDa of WED showed the highest inhibition of pro-inflammatory cytokine production, LPS-induced COX-2 expression and PEG2 production. These results suggest that WED fractions may have the anti-inflammatory effect via the stimulus of COX-2 and TNF-α in LPS-stimulated inflammation in RAW 264.7 cells. |
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Abstract The effect of water extracts of doenjang (WED) on cyclooxygenase pathway and cytokine production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells was investigated. WED was fractionated by ultrafiltration into five individual groups of molecular weights. All of the WED fractions significantly inhibited the production of prostaglandin E2 (PGE2) and expression of cyclooxygenase-2 (COX-2) in LPS-stimulated RAW 264.7 macrophages. Furthermore, each of the WED fractions significantly decreased production of pro-inflammatory cytokine such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) (p<0.05). The fraction between 10 to 30 kDa of WED showed the highest inhibition of pro-inflammatory cytokine production, LPS-induced COX-2 expression and PEG2 production. These results suggest that WED fractions may have the anti-inflammatory effect via the stimulus of COX-2 and TNF-α in LPS-stimulated inflammation in RAW 264.7 cells. |
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Anti-inflammatory effect of water extracts obtained from doenjang in LPS-stimulated RAW 264.7 cells |
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https://doi.org/10.1590/fst.15918 https://doaj.org/article/e91bc9faed5847958f931c5fefd71088 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612019005014101&lng=en&tlng=en https://doaj.org/toc/1678-457X |
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10.1590/fst.15918 |
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2024-07-03T21:16:12.292Z |
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