Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria.

Failure to establish an appropriate balance between pro- and anti-inflammatory immune responses is believed to contribute to pathogenesis of severe malaria. To determine whether this balance is maintained by classical regulatory T cells (CD4(+) FOXP3(+) CD127(-/low); Tregs) we compared cellular resp...
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Autor*in:	Michael Walther [verfasserIn] David Jeffries [verfasserIn] Olivia C Finney [verfasserIn] Madi Njie [verfasserIn] Augustine Ebonyi [verfasserIn] Susanne Deininger [verfasserIn] Emma Lawrence [verfasserIn] Alfred Ngwa-Amambua [verfasserIn] Shamanthi Jayasooriya [verfasserIn] Ian H Cheeseman [verfasserIn] Natalia Gomez-Escobar [verfasserIn] Joseph Okebe [verfasserIn] David J Conway [verfasserIn] Eleanor M Riley [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Übergeordnetes Werk:	In: PLoS Pathogens - Public Library of Science (PLoS), 2005, 5(2009), 4, p e1000364
Übergeordnetes Werk:	volume:5 ; year:2009 ; number:4, p e1000364

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1371/journal.ppat.1000364

Katalog-ID:	DOAJ001671685

Internformat


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Indexfelder

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publishDate	2009
allfields	10.1371/journal.ppat.1000364 doi (DE-627)DOAJ001671685 (DE-599)DOAJa777c8a9b1e64f4294fbd92e9cc339de DE-627 ger DE-627 rakwb eng RC581-607 QH301-705.5 Michael Walther verfasserin aut Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria. 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Failure to establish an appropriate balance between pro- and anti-inflammatory immune responses is believed to contribute to pathogenesis of severe malaria. To determine whether this balance is maintained by classical regulatory T cells (CD4(+) FOXP3(+) CD127(-/low); Tregs) we compared cellular responses between Gambian children (n = 124) with severe Plasmodium falciparum malaria or uncomplicated malaria infections. Although no significant differences in Treg numbers or function were observed between the groups, Treg activity during acute disease was inversely correlated with malaria-specific memory responses detectable 28 days later. Thus, while Tregs may not regulate acute malarial inflammation, they may limit memory responses to levels that subsequently facilitate parasite clearance without causing immunopathology. Importantly, we identified a population of FOXP3(-), CD45RO(+) CD4(+) T cells which coproduce IL-10 and IFN-gamma. These cells are more prevalent in children with uncomplicated malaria than in those with severe disease, suggesting that they may be the regulators of acute malarial inflammation. Immunologic diseases. Allergy Biology (General) David Jeffries verfasserin aut Olivia C Finney verfasserin aut Madi Njie verfasserin aut Augustine Ebonyi verfasserin aut Susanne Deininger verfasserin aut Emma Lawrence verfasserin aut Alfred Ngwa-Amambua verfasserin aut Shamanthi Jayasooriya verfasserin aut Ian H Cheeseman verfasserin aut Natalia Gomez-Escobar verfasserin aut Joseph Okebe verfasserin aut David J Conway verfasserin aut Eleanor M Riley verfasserin aut In PLoS Pathogens Public Library of Science (PLoS), 2005 5(2009), 4, p e1000364 (DE-627)501074422 (DE-600)2205412-1 15537374 nnns volume:5 year:2009 number:4, p e1000364 https://doi.org/10.1371/journal.ppat.1000364 kostenfrei https://doaj.org/article/a777c8a9b1e64f4294fbd92e9cc339de kostenfrei http://europepmc.org/articles/PMC2658808?pdf=render kostenfrei https://doaj.org/toc/1553-7366 Journal toc kostenfrei https://doaj.org/toc/1553-7374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 4, p e1000364
spelling	10.1371/journal.ppat.1000364 doi (DE-627)DOAJ001671685 (DE-599)DOAJa777c8a9b1e64f4294fbd92e9cc339de DE-627 ger DE-627 rakwb eng RC581-607 QH301-705.5 Michael Walther verfasserin aut Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria. 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Failure to establish an appropriate balance between pro- and anti-inflammatory immune responses is believed to contribute to pathogenesis of severe malaria. To determine whether this balance is maintained by classical regulatory T cells (CD4(+) FOXP3(+) CD127(-/low); Tregs) we compared cellular responses between Gambian children (n = 124) with severe Plasmodium falciparum malaria or uncomplicated malaria infections. Although no significant differences in Treg numbers or function were observed between the groups, Treg activity during acute disease was inversely correlated with malaria-specific memory responses detectable 28 days later. Thus, while Tregs may not regulate acute malarial inflammation, they may limit memory responses to levels that subsequently facilitate parasite clearance without causing immunopathology. Importantly, we identified a population of FOXP3(-), CD45RO(+) CD4(+) T cells which coproduce IL-10 and IFN-gamma. These cells are more prevalent in children with uncomplicated malaria than in those with severe disease, suggesting that they may be the regulators of acute malarial inflammation. Immunologic diseases. Allergy Biology (General) David Jeffries verfasserin aut Olivia C Finney verfasserin aut Madi Njie verfasserin aut Augustine Ebonyi verfasserin aut Susanne Deininger verfasserin aut Emma Lawrence verfasserin aut Alfred Ngwa-Amambua verfasserin aut Shamanthi Jayasooriya verfasserin aut Ian H Cheeseman verfasserin aut Natalia Gomez-Escobar verfasserin aut Joseph Okebe verfasserin aut David J Conway verfasserin aut Eleanor M Riley verfasserin aut In PLoS Pathogens Public Library of Science (PLoS), 2005 5(2009), 4, p e1000364 (DE-627)501074422 (DE-600)2205412-1 15537374 nnns volume:5 year:2009 number:4, p e1000364 https://doi.org/10.1371/journal.ppat.1000364 kostenfrei https://doaj.org/article/a777c8a9b1e64f4294fbd92e9cc339de kostenfrei http://europepmc.org/articles/PMC2658808?pdf=render kostenfrei https://doaj.org/toc/1553-7366 Journal toc kostenfrei https://doaj.org/toc/1553-7374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 4, p e1000364
allfields_unstemmed	10.1371/journal.ppat.1000364 doi (DE-627)DOAJ001671685 (DE-599)DOAJa777c8a9b1e64f4294fbd92e9cc339de DE-627 ger DE-627 rakwb eng RC581-607 QH301-705.5 Michael Walther verfasserin aut Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria. 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Failure to establish an appropriate balance between pro- and anti-inflammatory immune responses is believed to contribute to pathogenesis of severe malaria. To determine whether this balance is maintained by classical regulatory T cells (CD4(+) FOXP3(+) CD127(-/low); Tregs) we compared cellular responses between Gambian children (n = 124) with severe Plasmodium falciparum malaria or uncomplicated malaria infections. Although no significant differences in Treg numbers or function were observed between the groups, Treg activity during acute disease was inversely correlated with malaria-specific memory responses detectable 28 days later. Thus, while Tregs may not regulate acute malarial inflammation, they may limit memory responses to levels that subsequently facilitate parasite clearance without causing immunopathology. Importantly, we identified a population of FOXP3(-), CD45RO(+) CD4(+) T cells which coproduce IL-10 and IFN-gamma. These cells are more prevalent in children with uncomplicated malaria than in those with severe disease, suggesting that they may be the regulators of acute malarial inflammation. Immunologic diseases. Allergy Biology (General) David Jeffries verfasserin aut Olivia C Finney verfasserin aut Madi Njie verfasserin aut Augustine Ebonyi verfasserin aut Susanne Deininger verfasserin aut Emma Lawrence verfasserin aut Alfred Ngwa-Amambua verfasserin aut Shamanthi Jayasooriya verfasserin aut Ian H Cheeseman verfasserin aut Natalia Gomez-Escobar verfasserin aut Joseph Okebe verfasserin aut David J Conway verfasserin aut Eleanor M Riley verfasserin aut In PLoS Pathogens Public Library of Science (PLoS), 2005 5(2009), 4, p e1000364 (DE-627)501074422 (DE-600)2205412-1 15537374 nnns volume:5 year:2009 number:4, p e1000364 https://doi.org/10.1371/journal.ppat.1000364 kostenfrei https://doaj.org/article/a777c8a9b1e64f4294fbd92e9cc339de kostenfrei http://europepmc.org/articles/PMC2658808?pdf=render kostenfrei https://doaj.org/toc/1553-7366 Journal toc kostenfrei https://doaj.org/toc/1553-7374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 4, p e1000364
allfieldsGer	10.1371/journal.ppat.1000364 doi (DE-627)DOAJ001671685 (DE-599)DOAJa777c8a9b1e64f4294fbd92e9cc339de DE-627 ger DE-627 rakwb eng RC581-607 QH301-705.5 Michael Walther verfasserin aut Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria. 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Failure to establish an appropriate balance between pro- and anti-inflammatory immune responses is believed to contribute to pathogenesis of severe malaria. To determine whether this balance is maintained by classical regulatory T cells (CD4(+) FOXP3(+) CD127(-/low); Tregs) we compared cellular responses between Gambian children (n = 124) with severe Plasmodium falciparum malaria or uncomplicated malaria infections. Although no significant differences in Treg numbers or function were observed between the groups, Treg activity during acute disease was inversely correlated with malaria-specific memory responses detectable 28 days later. Thus, while Tregs may not regulate acute malarial inflammation, they may limit memory responses to levels that subsequently facilitate parasite clearance without causing immunopathology. Importantly, we identified a population of FOXP3(-), CD45RO(+) CD4(+) T cells which coproduce IL-10 and IFN-gamma. These cells are more prevalent in children with uncomplicated malaria than in those with severe disease, suggesting that they may be the regulators of acute malarial inflammation. Immunologic diseases. Allergy Biology (General) David Jeffries verfasserin aut Olivia C Finney verfasserin aut Madi Njie verfasserin aut Augustine Ebonyi verfasserin aut Susanne Deininger verfasserin aut Emma Lawrence verfasserin aut Alfred Ngwa-Amambua verfasserin aut Shamanthi Jayasooriya verfasserin aut Ian H Cheeseman verfasserin aut Natalia Gomez-Escobar verfasserin aut Joseph Okebe verfasserin aut David J Conway verfasserin aut Eleanor M Riley verfasserin aut In PLoS Pathogens Public Library of Science (PLoS), 2005 5(2009), 4, p e1000364 (DE-627)501074422 (DE-600)2205412-1 15537374 nnns volume:5 year:2009 number:4, p e1000364 https://doi.org/10.1371/journal.ppat.1000364 kostenfrei https://doaj.org/article/a777c8a9b1e64f4294fbd92e9cc339de kostenfrei http://europepmc.org/articles/PMC2658808?pdf=render kostenfrei https://doaj.org/toc/1553-7366 Journal toc kostenfrei https://doaj.org/toc/1553-7374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 4, p e1000364
allfieldsSound	10.1371/journal.ppat.1000364 doi (DE-627)DOAJ001671685 (DE-599)DOAJa777c8a9b1e64f4294fbd92e9cc339de DE-627 ger DE-627 rakwb eng RC581-607 QH301-705.5 Michael Walther verfasserin aut Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria. 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Failure to establish an appropriate balance between pro- and anti-inflammatory immune responses is believed to contribute to pathogenesis of severe malaria. To determine whether this balance is maintained by classical regulatory T cells (CD4(+) FOXP3(+) CD127(-/low); Tregs) we compared cellular responses between Gambian children (n = 124) with severe Plasmodium falciparum malaria or uncomplicated malaria infections. Although no significant differences in Treg numbers or function were observed between the groups, Treg activity during acute disease was inversely correlated with malaria-specific memory responses detectable 28 days later. Thus, while Tregs may not regulate acute malarial inflammation, they may limit memory responses to levels that subsequently facilitate parasite clearance without causing immunopathology. Importantly, we identified a population of FOXP3(-), CD45RO(+) CD4(+) T cells which coproduce IL-10 and IFN-gamma. These cells are more prevalent in children with uncomplicated malaria than in those with severe disease, suggesting that they may be the regulators of acute malarial inflammation. Immunologic diseases. Allergy Biology (General) David Jeffries verfasserin aut Olivia C Finney verfasserin aut Madi Njie verfasserin aut Augustine Ebonyi verfasserin aut Susanne Deininger verfasserin aut Emma Lawrence verfasserin aut Alfred Ngwa-Amambua verfasserin aut Shamanthi Jayasooriya verfasserin aut Ian H Cheeseman verfasserin aut Natalia Gomez-Escobar verfasserin aut Joseph Okebe verfasserin aut David J Conway verfasserin aut Eleanor M Riley verfasserin aut In PLoS Pathogens Public Library of Science (PLoS), 2005 5(2009), 4, p e1000364 (DE-627)501074422 (DE-600)2205412-1 15537374 nnns volume:5 year:2009 number:4, p e1000364 https://doi.org/10.1371/journal.ppat.1000364 kostenfrei https://doaj.org/article/a777c8a9b1e64f4294fbd92e9cc339de kostenfrei http://europepmc.org/articles/PMC2658808?pdf=render kostenfrei https://doaj.org/toc/1553-7366 Journal toc kostenfrei https://doaj.org/toc/1553-7374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 4, p e1000364
language	English
source	In PLoS Pathogens 5(2009), 4, p e1000364 volume:5 year:2009 number:4, p e1000364
sourceStr	In PLoS Pathogens 5(2009), 4, p e1000364 volume:5 year:2009 number:4, p e1000364
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Immunologic diseases. Allergy Biology (General)
isfreeaccess_bool	true
container_title	PLoS Pathogens
authorswithroles_txt_mv	Michael Walther @@aut@@ David Jeffries @@aut@@ Olivia C Finney @@aut@@ Madi Njie @@aut@@ Augustine Ebonyi @@aut@@ Susanne Deininger @@aut@@ Emma Lawrence @@aut@@ Alfred Ngwa-Amambua @@aut@@ Shamanthi Jayasooriya @@aut@@ Ian H Cheeseman @@aut@@ Natalia Gomez-Escobar @@aut@@ Joseph Okebe @@aut@@ David J Conway @@aut@@ Eleanor M Riley @@aut@@
publishDateDaySort_date	2009-01-01T00:00:00Z
hierarchy_top_id	501074422
id	DOAJ001671685
language_de	englisch
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callnumber-first	R - Medicine
author	Michael Walther
spellingShingle	Michael Walther misc RC581-607 misc QH301-705.5 misc Immunologic diseases. Allergy misc Biology (General) Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria.
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topic_title	RC581-607 QH301-705.5 Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria
topic	misc RC581-607 misc QH301-705.5 misc Immunologic diseases. Allergy misc Biology (General)
topic_unstemmed	misc RC581-607 misc QH301-705.5 misc Immunologic diseases. Allergy misc Biology (General)
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title	Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria.
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title_full	Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria
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author_browse	Michael Walther David Jeffries Olivia C Finney Madi Njie Augustine Ebonyi Susanne Deininger Emma Lawrence Alfred Ngwa-Amambua Shamanthi Jayasooriya Ian H Cheeseman Natalia Gomez-Escobar Joseph Okebe David J Conway Eleanor M Riley
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title_sort	distinct roles for foxp3 and foxp3 cd4 t cells in regulating cellular immunity to uncomplicated and severe plasmodium falciparum malaria
callnumber	RC581-607
title_auth	Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria.
abstract	Failure to establish an appropriate balance between pro- and anti-inflammatory immune responses is believed to contribute to pathogenesis of severe malaria. To determine whether this balance is maintained by classical regulatory T cells (CD4(+) FOXP3(+) CD127(-/low); Tregs) we compared cellular responses between Gambian children (n = 124) with severe Plasmodium falciparum malaria or uncomplicated malaria infections. Although no significant differences in Treg numbers or function were observed between the groups, Treg activity during acute disease was inversely correlated with malaria-specific memory responses detectable 28 days later. Thus, while Tregs may not regulate acute malarial inflammation, they may limit memory responses to levels that subsequently facilitate parasite clearance without causing immunopathology. Importantly, we identified a population of FOXP3(-), CD45RO(+) CD4(+) T cells which coproduce IL-10 and IFN-gamma. These cells are more prevalent in children with uncomplicated malaria than in those with severe disease, suggesting that they may be the regulators of acute malarial inflammation.
abstractGer	Failure to establish an appropriate balance between pro- and anti-inflammatory immune responses is believed to contribute to pathogenesis of severe malaria. To determine whether this balance is maintained by classical regulatory T cells (CD4(+) FOXP3(+) CD127(-/low); Tregs) we compared cellular responses between Gambian children (n = 124) with severe Plasmodium falciparum malaria or uncomplicated malaria infections. Although no significant differences in Treg numbers or function were observed between the groups, Treg activity during acute disease was inversely correlated with malaria-specific memory responses detectable 28 days later. Thus, while Tregs may not regulate acute malarial inflammation, they may limit memory responses to levels that subsequently facilitate parasite clearance without causing immunopathology. Importantly, we identified a population of FOXP3(-), CD45RO(+) CD4(+) T cells which coproduce IL-10 and IFN-gamma. These cells are more prevalent in children with uncomplicated malaria than in those with severe disease, suggesting that they may be the regulators of acute malarial inflammation.
abstract_unstemmed	Failure to establish an appropriate balance between pro- and anti-inflammatory immune responses is believed to contribute to pathogenesis of severe malaria. To determine whether this balance is maintained by classical regulatory T cells (CD4(+) FOXP3(+) CD127(-/low); Tregs) we compared cellular responses between Gambian children (n = 124) with severe Plasmodium falciparum malaria or uncomplicated malaria infections. Although no significant differences in Treg numbers or function were observed between the groups, Treg activity during acute disease was inversely correlated with malaria-specific memory responses detectable 28 days later. Thus, while Tregs may not regulate acute malarial inflammation, they may limit memory responses to levels that subsequently facilitate parasite clearance without causing immunopathology. Importantly, we identified a population of FOXP3(-), CD45RO(+) CD4(+) T cells which coproduce IL-10 and IFN-gamma. These cells are more prevalent in children with uncomplicated malaria than in those with severe disease, suggesting that they may be the regulators of acute malarial inflammation.
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title_short	Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria.
url	https://doi.org/10.1371/journal.ppat.1000364 https://doaj.org/article/a777c8a9b1e64f4294fbd92e9cc339de http://europepmc.org/articles/PMC2658808?pdf=render https://doaj.org/toc/1553-7366 https://doaj.org/toc/1553-7374
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up_date	2024-07-03T21:46:58.510Z
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Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria.

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