Comparative Genomics of the Transport Proteins of Ten <i<Lactobacillus</i< Strains

The genus <i<Lactobacillus</i< includes species that may inhabit different anatomical locations in the human body, but the greatest percentage of its species are inhabitants of the gut. Lactobacilli are well known for their probiotic characteristics, although some species may become path...
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Autor*in:	Hassan Zafar [verfasserIn] Milton H. Saier [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	transport proteins probiotic pathogenic

Übergeordnetes Werk:	In: Genes - MDPI AG, 2010, 11(2020), 10, p 1234
Übergeordnetes Werk:	volume:11 ; year:2020 ; number:10, p 1234

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/genes11101234

Katalog-ID:	DOAJ001704354

Internformat


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520			\|a The genus <i<Lactobacillus</i< includes species that may inhabit different anatomical locations in the human body, but the greatest percentage of its species are inhabitants of the gut. Lactobacilli are well known for their probiotic characteristics, although some species may become pathogenic and exert negative effects on human health. The transportome of an organism consists of the sum of the transport proteins encoded within its genome, and studies on the transportome help in the understanding of the various physiological processes taking place in the cell. In this communication we analyze the transport proteins and predict probable substrate specificities of ten <i<Lactobacillus</i< strains. Six of these strains (<i<L. brevis</i<, <i<L. bulgaricus</i<, <i<L. crispatus</i<, <i<L. gasseri</i<, <i<L. reuteri</i<, <i<and L. ruminis</i<) are currently believed to be only probiotic (OP). The remaining four strains (<i<L. acidophilus</i<, <i<L. paracasei, L. planatarum, and L. rhamnosus)</i< can play dual roles, being both probiotic and pathogenic (PAP). The characteristics of the transport systems found in these bacteria were compared with strains (<i<E. coli</i<, <i<Salmonella</i<, and <i<Bacteroides</i<) from our previous studies. Overall, the ten lactobacilli contain high numbers of amino acid transporters, but the PAP strains contain higher number of sugar, amino acid and peptide transporters as well as drug exporters than their OP counterparts. Moreover, some of the OP strains contain pore-forming toxins and drug exporters similar to those of the PAP strains, thus indicative of yet unrecognized pathogenic potential. The transportomes of the lactobacilli seem to be finely tuned according to the extracellular and probiotic lifestyles of these organisms. Taken together, the results of this study help to reveal the physiological and pathogenic potential of common prokaryotic residents in the human body.
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allfields	10.3390/genes11101234 doi (DE-627)DOAJ001704354 (DE-599)DOAJ7e5fcd62337e4ae7bc4e469ef9d5a88f DE-627 ger DE-627 rakwb eng QH426-470 Hassan Zafar verfasserin aut Comparative Genomics of the Transport Proteins of Ten <i<Lactobacillus</i< Strains 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The genus <i<Lactobacillus</i< includes species that may inhabit different anatomical locations in the human body, but the greatest percentage of its species are inhabitants of the gut. Lactobacilli are well known for their probiotic characteristics, although some species may become pathogenic and exert negative effects on human health. The transportome of an organism consists of the sum of the transport proteins encoded within its genome, and studies on the transportome help in the understanding of the various physiological processes taking place in the cell. In this communication we analyze the transport proteins and predict probable substrate specificities of ten <i<Lactobacillus</i< strains. Six of these strains (<i<L. brevis</i<, <i<L. bulgaricus</i<, <i<L. crispatus</i<, <i<L. gasseri</i<, <i<L. reuteri</i<, <i<and L. ruminis</i<) are currently believed to be only probiotic (OP). The remaining four strains (<i<L. acidophilus</i<, <i<L. paracasei, L. planatarum, and L. rhamnosus)</i< can play dual roles, being both probiotic and pathogenic (PAP). The characteristics of the transport systems found in these bacteria were compared with strains (<i<E. coli</i<, <i<Salmonella</i<, and <i<Bacteroides</i<) from our previous studies. Overall, the ten lactobacilli contain high numbers of amino acid transporters, but the PAP strains contain higher number of sugar, amino acid and peptide transporters as well as drug exporters than their OP counterparts. Moreover, some of the OP strains contain pore-forming toxins and drug exporters similar to those of the PAP strains, thus indicative of yet unrecognized pathogenic potential. The transportomes of the lactobacilli seem to be finely tuned according to the extracellular and probiotic lifestyles of these organisms. Taken together, the results of this study help to reveal the physiological and pathogenic potential of common prokaryotic residents in the human body. <i<Lactobacillus</i< transport proteins probiotic pathogenic Genetics Milton H. Saier verfasserin aut In Genes MDPI AG, 2010 11(2020), 10, p 1234 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:11 year:2020 number:10, p 1234 https://doi.org/10.3390/genes11101234 kostenfrei https://doaj.org/article/7e5fcd62337e4ae7bc4e469ef9d5a88f kostenfrei https://www.mdpi.com/2073-4425/11/10/1234 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 10, p 1234
spelling	10.3390/genes11101234 doi (DE-627)DOAJ001704354 (DE-599)DOAJ7e5fcd62337e4ae7bc4e469ef9d5a88f DE-627 ger DE-627 rakwb eng QH426-470 Hassan Zafar verfasserin aut Comparative Genomics of the Transport Proteins of Ten <i<Lactobacillus</i< Strains 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The genus <i<Lactobacillus</i< includes species that may inhabit different anatomical locations in the human body, but the greatest percentage of its species are inhabitants of the gut. Lactobacilli are well known for their probiotic characteristics, although some species may become pathogenic and exert negative effects on human health. The transportome of an organism consists of the sum of the transport proteins encoded within its genome, and studies on the transportome help in the understanding of the various physiological processes taking place in the cell. In this communication we analyze the transport proteins and predict probable substrate specificities of ten <i<Lactobacillus</i< strains. Six of these strains (<i<L. brevis</i<, <i<L. bulgaricus</i<, <i<L. crispatus</i<, <i<L. gasseri</i<, <i<L. reuteri</i<, <i<and L. ruminis</i<) are currently believed to be only probiotic (OP). The remaining four strains (<i<L. acidophilus</i<, <i<L. paracasei, L. planatarum, and L. rhamnosus)</i< can play dual roles, being both probiotic and pathogenic (PAP). The characteristics of the transport systems found in these bacteria were compared with strains (<i<E. coli</i<, <i<Salmonella</i<, and <i<Bacteroides</i<) from our previous studies. Overall, the ten lactobacilli contain high numbers of amino acid transporters, but the PAP strains contain higher number of sugar, amino acid and peptide transporters as well as drug exporters than their OP counterparts. Moreover, some of the OP strains contain pore-forming toxins and drug exporters similar to those of the PAP strains, thus indicative of yet unrecognized pathogenic potential. The transportomes of the lactobacilli seem to be finely tuned according to the extracellular and probiotic lifestyles of these organisms. Taken together, the results of this study help to reveal the physiological and pathogenic potential of common prokaryotic residents in the human body. <i<Lactobacillus</i< transport proteins probiotic pathogenic Genetics Milton H. Saier verfasserin aut In Genes MDPI AG, 2010 11(2020), 10, p 1234 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:11 year:2020 number:10, p 1234 https://doi.org/10.3390/genes11101234 kostenfrei https://doaj.org/article/7e5fcd62337e4ae7bc4e469ef9d5a88f kostenfrei https://www.mdpi.com/2073-4425/11/10/1234 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 10, p 1234
allfields_unstemmed	10.3390/genes11101234 doi (DE-627)DOAJ001704354 (DE-599)DOAJ7e5fcd62337e4ae7bc4e469ef9d5a88f DE-627 ger DE-627 rakwb eng QH426-470 Hassan Zafar verfasserin aut Comparative Genomics of the Transport Proteins of Ten <i<Lactobacillus</i< Strains 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The genus <i<Lactobacillus</i< includes species that may inhabit different anatomical locations in the human body, but the greatest percentage of its species are inhabitants of the gut. Lactobacilli are well known for their probiotic characteristics, although some species may become pathogenic and exert negative effects on human health. The transportome of an organism consists of the sum of the transport proteins encoded within its genome, and studies on the transportome help in the understanding of the various physiological processes taking place in the cell. In this communication we analyze the transport proteins and predict probable substrate specificities of ten <i<Lactobacillus</i< strains. Six of these strains (<i<L. brevis</i<, <i<L. bulgaricus</i<, <i<L. crispatus</i<, <i<L. gasseri</i<, <i<L. reuteri</i<, <i<and L. ruminis</i<) are currently believed to be only probiotic (OP). The remaining four strains (<i<L. acidophilus</i<, <i<L. paracasei, L. planatarum, and L. rhamnosus)</i< can play dual roles, being both probiotic and pathogenic (PAP). The characteristics of the transport systems found in these bacteria were compared with strains (<i<E. coli</i<, <i<Salmonella</i<, and <i<Bacteroides</i<) from our previous studies. Overall, the ten lactobacilli contain high numbers of amino acid transporters, but the PAP strains contain higher number of sugar, amino acid and peptide transporters as well as drug exporters than their OP counterparts. Moreover, some of the OP strains contain pore-forming toxins and drug exporters similar to those of the PAP strains, thus indicative of yet unrecognized pathogenic potential. The transportomes of the lactobacilli seem to be finely tuned according to the extracellular and probiotic lifestyles of these organisms. Taken together, the results of this study help to reveal the physiological and pathogenic potential of common prokaryotic residents in the human body. <i<Lactobacillus</i< transport proteins probiotic pathogenic Genetics Milton H. Saier verfasserin aut In Genes MDPI AG, 2010 11(2020), 10, p 1234 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:11 year:2020 number:10, p 1234 https://doi.org/10.3390/genes11101234 kostenfrei https://doaj.org/article/7e5fcd62337e4ae7bc4e469ef9d5a88f kostenfrei https://www.mdpi.com/2073-4425/11/10/1234 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 10, p 1234
allfieldsGer	10.3390/genes11101234 doi (DE-627)DOAJ001704354 (DE-599)DOAJ7e5fcd62337e4ae7bc4e469ef9d5a88f DE-627 ger DE-627 rakwb eng QH426-470 Hassan Zafar verfasserin aut Comparative Genomics of the Transport Proteins of Ten <i<Lactobacillus</i< Strains 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The genus <i<Lactobacillus</i< includes species that may inhabit different anatomical locations in the human body, but the greatest percentage of its species are inhabitants of the gut. Lactobacilli are well known for their probiotic characteristics, although some species may become pathogenic and exert negative effects on human health. The transportome of an organism consists of the sum of the transport proteins encoded within its genome, and studies on the transportome help in the understanding of the various physiological processes taking place in the cell. In this communication we analyze the transport proteins and predict probable substrate specificities of ten <i<Lactobacillus</i< strains. Six of these strains (<i<L. brevis</i<, <i<L. bulgaricus</i<, <i<L. crispatus</i<, <i<L. gasseri</i<, <i<L. reuteri</i<, <i<and L. ruminis</i<) are currently believed to be only probiotic (OP). The remaining four strains (<i<L. acidophilus</i<, <i<L. paracasei, L. planatarum, and L. rhamnosus)</i< can play dual roles, being both probiotic and pathogenic (PAP). The characteristics of the transport systems found in these bacteria were compared with strains (<i<E. coli</i<, <i<Salmonella</i<, and <i<Bacteroides</i<) from our previous studies. Overall, the ten lactobacilli contain high numbers of amino acid transporters, but the PAP strains contain higher number of sugar, amino acid and peptide transporters as well as drug exporters than their OP counterparts. Moreover, some of the OP strains contain pore-forming toxins and drug exporters similar to those of the PAP strains, thus indicative of yet unrecognized pathogenic potential. The transportomes of the lactobacilli seem to be finely tuned according to the extracellular and probiotic lifestyles of these organisms. Taken together, the results of this study help to reveal the physiological and pathogenic potential of common prokaryotic residents in the human body. <i<Lactobacillus</i< transport proteins probiotic pathogenic Genetics Milton H. Saier verfasserin aut In Genes MDPI AG, 2010 11(2020), 10, p 1234 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:11 year:2020 number:10, p 1234 https://doi.org/10.3390/genes11101234 kostenfrei https://doaj.org/article/7e5fcd62337e4ae7bc4e469ef9d5a88f kostenfrei https://www.mdpi.com/2073-4425/11/10/1234 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 10, p 1234
allfieldsSound	10.3390/genes11101234 doi (DE-627)DOAJ001704354 (DE-599)DOAJ7e5fcd62337e4ae7bc4e469ef9d5a88f DE-627 ger DE-627 rakwb eng QH426-470 Hassan Zafar verfasserin aut Comparative Genomics of the Transport Proteins of Ten <i<Lactobacillus</i< Strains 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The genus <i<Lactobacillus</i< includes species that may inhabit different anatomical locations in the human body, but the greatest percentage of its species are inhabitants of the gut. Lactobacilli are well known for their probiotic characteristics, although some species may become pathogenic and exert negative effects on human health. The transportome of an organism consists of the sum of the transport proteins encoded within its genome, and studies on the transportome help in the understanding of the various physiological processes taking place in the cell. In this communication we analyze the transport proteins and predict probable substrate specificities of ten <i<Lactobacillus</i< strains. Six of these strains (<i<L. brevis</i<, <i<L. bulgaricus</i<, <i<L. crispatus</i<, <i<L. gasseri</i<, <i<L. reuteri</i<, <i<and L. ruminis</i<) are currently believed to be only probiotic (OP). The remaining four strains (<i<L. acidophilus</i<, <i<L. paracasei, L. planatarum, and L. rhamnosus)</i< can play dual roles, being both probiotic and pathogenic (PAP). The characteristics of the transport systems found in these bacteria were compared with strains (<i<E. coli</i<, <i<Salmonella</i<, and <i<Bacteroides</i<) from our previous studies. Overall, the ten lactobacilli contain high numbers of amino acid transporters, but the PAP strains contain higher number of sugar, amino acid and peptide transporters as well as drug exporters than their OP counterparts. Moreover, some of the OP strains contain pore-forming toxins and drug exporters similar to those of the PAP strains, thus indicative of yet unrecognized pathogenic potential. The transportomes of the lactobacilli seem to be finely tuned according to the extracellular and probiotic lifestyles of these organisms. Taken together, the results of this study help to reveal the physiological and pathogenic potential of common prokaryotic residents in the human body. <i<Lactobacillus</i< transport proteins probiotic pathogenic Genetics Milton H. Saier verfasserin aut In Genes MDPI AG, 2010 11(2020), 10, p 1234 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:11 year:2020 number:10, p 1234 https://doi.org/10.3390/genes11101234 kostenfrei https://doaj.org/article/7e5fcd62337e4ae7bc4e469ef9d5a88f kostenfrei https://www.mdpi.com/2073-4425/11/10/1234 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 10, p 1234
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callnumber-first	Q - Science
author	Hassan Zafar
spellingShingle	Hassan Zafar misc QH426-470 misc <i<Lactobacillus</i< misc transport proteins misc probiotic misc pathogenic misc Genetics Comparative Genomics of the Transport Proteins of Ten <i<Lactobacillus</i< Strains
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topic_title	QH426-470 Comparative Genomics of the Transport Proteins of Ten <i<Lactobacillus</i< Strains <i<Lactobacillus</i< transport proteins probiotic pathogenic
topic	misc QH426-470 misc <i<Lactobacillus</i< misc transport proteins misc probiotic misc pathogenic misc Genetics
topic_unstemmed	misc QH426-470 misc <i<Lactobacillus</i< misc transport proteins misc probiotic misc pathogenic misc Genetics
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title	Comparative Genomics of the Transport Proteins of Ten <i<Lactobacillus</i< Strains
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title_full	Comparative Genomics of the Transport Proteins of Ten <i<Lactobacillus</i< Strains
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title_sort	comparative genomics of the transport proteins of ten <i<lactobacillus</i< strains
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title_auth	Comparative Genomics of the Transport Proteins of Ten <i<Lactobacillus</i< Strains
abstract	The genus <i<Lactobacillus</i< includes species that may inhabit different anatomical locations in the human body, but the greatest percentage of its species are inhabitants of the gut. Lactobacilli are well known for their probiotic characteristics, although some species may become pathogenic and exert negative effects on human health. The transportome of an organism consists of the sum of the transport proteins encoded within its genome, and studies on the transportome help in the understanding of the various physiological processes taking place in the cell. In this communication we analyze the transport proteins and predict probable substrate specificities of ten <i<Lactobacillus</i< strains. Six of these strains (<i<L. brevis</i<, <i<L. bulgaricus</i<, <i<L. crispatus</i<, <i<L. gasseri</i<, <i<L. reuteri</i<, <i<and L. ruminis</i<) are currently believed to be only probiotic (OP). The remaining four strains (<i<L. acidophilus</i<, <i<L. paracasei, L. planatarum, and L. rhamnosus)</i< can play dual roles, being both probiotic and pathogenic (PAP). The characteristics of the transport systems found in these bacteria were compared with strains (<i<E. coli</i<, <i<Salmonella</i<, and <i<Bacteroides</i<) from our previous studies. Overall, the ten lactobacilli contain high numbers of amino acid transporters, but the PAP strains contain higher number of sugar, amino acid and peptide transporters as well as drug exporters than their OP counterparts. Moreover, some of the OP strains contain pore-forming toxins and drug exporters similar to those of the PAP strains, thus indicative of yet unrecognized pathogenic potential. The transportomes of the lactobacilli seem to be finely tuned according to the extracellular and probiotic lifestyles of these organisms. Taken together, the results of this study help to reveal the physiological and pathogenic potential of common prokaryotic residents in the human body.
abstractGer	The genus <i<Lactobacillus</i< includes species that may inhabit different anatomical locations in the human body, but the greatest percentage of its species are inhabitants of the gut. Lactobacilli are well known for their probiotic characteristics, although some species may become pathogenic and exert negative effects on human health. The transportome of an organism consists of the sum of the transport proteins encoded within its genome, and studies on the transportome help in the understanding of the various physiological processes taking place in the cell. In this communication we analyze the transport proteins and predict probable substrate specificities of ten <i<Lactobacillus</i< strains. Six of these strains (<i<L. brevis</i<, <i<L. bulgaricus</i<, <i<L. crispatus</i<, <i<L. gasseri</i<, <i<L. reuteri</i<, <i<and L. ruminis</i<) are currently believed to be only probiotic (OP). The remaining four strains (<i<L. acidophilus</i<, <i<L. paracasei, L. planatarum, and L. rhamnosus)</i< can play dual roles, being both probiotic and pathogenic (PAP). The characteristics of the transport systems found in these bacteria were compared with strains (<i<E. coli</i<, <i<Salmonella</i<, and <i<Bacteroides</i<) from our previous studies. Overall, the ten lactobacilli contain high numbers of amino acid transporters, but the PAP strains contain higher number of sugar, amino acid and peptide transporters as well as drug exporters than their OP counterparts. Moreover, some of the OP strains contain pore-forming toxins and drug exporters similar to those of the PAP strains, thus indicative of yet unrecognized pathogenic potential. The transportomes of the lactobacilli seem to be finely tuned according to the extracellular and probiotic lifestyles of these organisms. Taken together, the results of this study help to reveal the physiological and pathogenic potential of common prokaryotic residents in the human body.
abstract_unstemmed	The genus <i<Lactobacillus</i< includes species that may inhabit different anatomical locations in the human body, but the greatest percentage of its species are inhabitants of the gut. Lactobacilli are well known for their probiotic characteristics, although some species may become pathogenic and exert negative effects on human health. The transportome of an organism consists of the sum of the transport proteins encoded within its genome, and studies on the transportome help in the understanding of the various physiological processes taking place in the cell. In this communication we analyze the transport proteins and predict probable substrate specificities of ten <i<Lactobacillus</i< strains. Six of these strains (<i<L. brevis</i<, <i<L. bulgaricus</i<, <i<L. crispatus</i<, <i<L. gasseri</i<, <i<L. reuteri</i<, <i<and L. ruminis</i<) are currently believed to be only probiotic (OP). The remaining four strains (<i<L. acidophilus</i<, <i<L. paracasei, L. planatarum, and L. rhamnosus)</i< can play dual roles, being both probiotic and pathogenic (PAP). The characteristics of the transport systems found in these bacteria were compared with strains (<i<E. coli</i<, <i<Salmonella</i<, and <i<Bacteroides</i<) from our previous studies. Overall, the ten lactobacilli contain high numbers of amino acid transporters, but the PAP strains contain higher number of sugar, amino acid and peptide transporters as well as drug exporters than their OP counterparts. Moreover, some of the OP strains contain pore-forming toxins and drug exporters similar to those of the PAP strains, thus indicative of yet unrecognized pathogenic potential. The transportomes of the lactobacilli seem to be finely tuned according to the extracellular and probiotic lifestyles of these organisms. Taken together, the results of this study help to reveal the physiological and pathogenic potential of common prokaryotic residents in the human body.
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title_short	Comparative Genomics of the Transport Proteins of Ten <i<Lactobacillus</i< Strains
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Comparative Genomics of the Transport Proteins of Ten <i<Lactobacillus</i< Strains

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