Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons.
The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinati...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Erling Mellerup [verfasserIn] Ole A Andreassen [verfasserIn] Bente Bennike [verfasserIn] Henrik Dam [verfasserIn] Srdjan Djurovic [verfasserIn] Thomas Hansen [verfasserIn] Martin Balslev Jorgensen [verfasserIn] Lars Vedel Kessing [verfasserIn] Pernille Koefoed [verfasserIn] Ingrid Melle [verfasserIn] Ole Mors [verfasserIn] Thomas Werge [verfasserIn] Gert Lykke Moeller [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Übergeordnetes Werk: |
In: PLoS ONE - Public Library of Science (PLoS), 2007, 10(2015), 11, p e0143432 |
|---|---|
| Übergeordnetes Werk: |
volume:10 ; year:2015 ; number:11, p e0143432 |
| Links: |
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| DOI / URN: |
10.1371/journal.pone.0143432 |
|---|
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DOAJ001798405 |
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10.1371/journal.pone.0143432 doi (DE-627)DOAJ001798405 (DE-599)DOAJ43b4c2130b5d4ab6ad17f5aff00bbafb DE-627 ger DE-627 rakwb eng Erling Mellerup verfasserin aut Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons. 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome. Medicine R Science Q Ole A Andreassen verfasserin aut Bente Bennike verfasserin aut Henrik Dam verfasserin aut Srdjan Djurovic verfasserin aut Thomas Hansen verfasserin aut Martin Balslev Jorgensen verfasserin aut Lars Vedel Kessing verfasserin aut Pernille Koefoed verfasserin aut Ingrid Melle verfasserin aut Ole Mors verfasserin aut Thomas Werge verfasserin aut Gert Lykke Moeller verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 10(2015), 11, p e0143432 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:10 year:2015 number:11, p e0143432 https://doi.org/10.1371/journal.pone.0143432 kostenfrei https://doaj.org/article/43b4c2130b5d4ab6ad17f5aff00bbafb kostenfrei http://europepmc.org/articles/PMC4654514?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2015 11, p e0143432 |
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10.1371/journal.pone.0143432 doi (DE-627)DOAJ001798405 (DE-599)DOAJ43b4c2130b5d4ab6ad17f5aff00bbafb DE-627 ger DE-627 rakwb eng Erling Mellerup verfasserin aut Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons. 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome. Medicine R Science Q Ole A Andreassen verfasserin aut Bente Bennike verfasserin aut Henrik Dam verfasserin aut Srdjan Djurovic verfasserin aut Thomas Hansen verfasserin aut Martin Balslev Jorgensen verfasserin aut Lars Vedel Kessing verfasserin aut Pernille Koefoed verfasserin aut Ingrid Melle verfasserin aut Ole Mors verfasserin aut Thomas Werge verfasserin aut Gert Lykke Moeller verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 10(2015), 11, p e0143432 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:10 year:2015 number:11, p e0143432 https://doi.org/10.1371/journal.pone.0143432 kostenfrei https://doaj.org/article/43b4c2130b5d4ab6ad17f5aff00bbafb kostenfrei http://europepmc.org/articles/PMC4654514?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2015 11, p e0143432 |
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10.1371/journal.pone.0143432 doi (DE-627)DOAJ001798405 (DE-599)DOAJ43b4c2130b5d4ab6ad17f5aff00bbafb DE-627 ger DE-627 rakwb eng Erling Mellerup verfasserin aut Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons. 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome. Medicine R Science Q Ole A Andreassen verfasserin aut Bente Bennike verfasserin aut Henrik Dam verfasserin aut Srdjan Djurovic verfasserin aut Thomas Hansen verfasserin aut Martin Balslev Jorgensen verfasserin aut Lars Vedel Kessing verfasserin aut Pernille Koefoed verfasserin aut Ingrid Melle verfasserin aut Ole Mors verfasserin aut Thomas Werge verfasserin aut Gert Lykke Moeller verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 10(2015), 11, p e0143432 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:10 year:2015 number:11, p e0143432 https://doi.org/10.1371/journal.pone.0143432 kostenfrei https://doaj.org/article/43b4c2130b5d4ab6ad17f5aff00bbafb kostenfrei http://europepmc.org/articles/PMC4654514?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2015 11, p e0143432 |
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10.1371/journal.pone.0143432 doi (DE-627)DOAJ001798405 (DE-599)DOAJ43b4c2130b5d4ab6ad17f5aff00bbafb DE-627 ger DE-627 rakwb eng Erling Mellerup verfasserin aut Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons. 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome. Medicine R Science Q Ole A Andreassen verfasserin aut Bente Bennike verfasserin aut Henrik Dam verfasserin aut Srdjan Djurovic verfasserin aut Thomas Hansen verfasserin aut Martin Balslev Jorgensen verfasserin aut Lars Vedel Kessing verfasserin aut Pernille Koefoed verfasserin aut Ingrid Melle verfasserin aut Ole Mors verfasserin aut Thomas Werge verfasserin aut Gert Lykke Moeller verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 10(2015), 11, p e0143432 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:10 year:2015 number:11, p e0143432 https://doi.org/10.1371/journal.pone.0143432 kostenfrei https://doaj.org/article/43b4c2130b5d4ab6ad17f5aff00bbafb kostenfrei http://europepmc.org/articles/PMC4654514?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2015 11, p e0143432 |
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Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons. |
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Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons |
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Erling Mellerup |
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Erling Mellerup Ole A Andreassen Bente Bennike Henrik Dam Srdjan Djurovic Thomas Hansen Martin Balslev Jorgensen Lars Vedel Kessing Pernille Koefoed Ingrid Melle Ole Mors Thomas Werge Gert Lykke Moeller |
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combinations of genetic data present in bipolar patients, but absent in control persons |
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Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons. |
| abstract |
The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome. |
| abstractGer |
The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome. |
| abstract_unstemmed |
The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome. |
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