Adult Mild Encephalitis With Reversible Splenial Lesion Associated With Delirious Mania: A Case Report

Mild encephalitis with reversible splenial lesion is a rare clinic-radiological entity presenting with neurological and neuropsychiatric symptoms associated with cerebral lesion/s. Delirious mania is a severe psychiatric syndrome characterized by acute onset of delirium, excitement, and psychosis wi...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Marcella Bellani [verfasserIn] Giovanni Zanette [verfasserIn] Niccolò Zovetti [verfasserIn] Marco Barillari [verfasserIn] Lidia Del Piccolo [verfasserIn] Paolo Brambilla [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	encephalitis manic state neuroimaging deep sedation propofol

Übergeordnetes Werk:	In: Frontiers in Psychiatry - Frontiers Media S.A., 2010, 11(2020)
Übergeordnetes Werk:	volume:11 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fpsyt.2020.00079

Katalog-ID:	DOAJ001807560

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authorswithroles_txt_mv	Marcella Bellani @@aut@@ Giovanni Zanette @@aut@@ Niccolò Zovetti @@aut@@ Marco Barillari @@aut@@ Lidia Del Piccolo @@aut@@ Paolo Brambilla @@aut@@
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author	Marcella Bellani
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topic_title	RC435-571 Adult Mild Encephalitis With Reversible Splenial Lesion Associated With Delirious Mania: A Case Report encephalitis manic state neuroimaging deep sedation propofol
topic	misc RC435-571 misc encephalitis misc manic state misc neuroimaging misc deep sedation misc propofol misc Psychiatry
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title	Adult Mild Encephalitis With Reversible Splenial Lesion Associated With Delirious Mania: A Case Report
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title_full	Adult Mild Encephalitis With Reversible Splenial Lesion Associated With Delirious Mania: A Case Report
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title_sort	adult mild encephalitis with reversible splenial lesion associated with delirious mania: a case report
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title_auth	Adult Mild Encephalitis With Reversible Splenial Lesion Associated With Delirious Mania: A Case Report
abstract	Mild encephalitis with reversible splenial lesion is a rare clinic-radiological entity presenting with neurological and neuropsychiatric symptoms associated with cerebral lesion/s. Delirious mania is a severe psychiatric syndrome characterized by acute onset of delirium, excitement, and psychosis with a high mortality rate. In this paper, we present a case report of mild encephalitis with reversible splenial lesion clinically presenting as delirious mania and evolving into life-threatening multi-organ failure. The patient was treated with aripiprazole and benzodiazepine with poor effect and, after 4 days, the patient's condition significantly worsened requiring transfer to the intensive care unit where deep sedation with propofol was started. Our findings are in contrast with the traditional literature description of self-resolving and harmless mild encephalitis with reversible splenial lesion. Moreover, rapid clinical recovery and the progressive improvement of psychiatric symptoms after deep sedation with propofol in this case—considering propofol's neuroprotective and anti-inflammatory effects—supports the notion of propofol-mediated deep sedation for the treatment of severe manic symptoms associated with life-threatening conditions. Little is known about neural markers of the manic state, and the corpus callosum has been described to be involved in bipolar disorder. Abnormalities in this structure may represent a marker of vulnerability for this disorder.
abstractGer	Mild encephalitis with reversible splenial lesion is a rare clinic-radiological entity presenting with neurological and neuropsychiatric symptoms associated with cerebral lesion/s. Delirious mania is a severe psychiatric syndrome characterized by acute onset of delirium, excitement, and psychosis with a high mortality rate. In this paper, we present a case report of mild encephalitis with reversible splenial lesion clinically presenting as delirious mania and evolving into life-threatening multi-organ failure. The patient was treated with aripiprazole and benzodiazepine with poor effect and, after 4 days, the patient's condition significantly worsened requiring transfer to the intensive care unit where deep sedation with propofol was started. Our findings are in contrast with the traditional literature description of self-resolving and harmless mild encephalitis with reversible splenial lesion. Moreover, rapid clinical recovery and the progressive improvement of psychiatric symptoms after deep sedation with propofol in this case—considering propofol's neuroprotective and anti-inflammatory effects—supports the notion of propofol-mediated deep sedation for the treatment of severe manic symptoms associated with life-threatening conditions. Little is known about neural markers of the manic state, and the corpus callosum has been described to be involved in bipolar disorder. Abnormalities in this structure may represent a marker of vulnerability for this disorder.
abstract_unstemmed	Mild encephalitis with reversible splenial lesion is a rare clinic-radiological entity presenting with neurological and neuropsychiatric symptoms associated with cerebral lesion/s. Delirious mania is a severe psychiatric syndrome characterized by acute onset of delirium, excitement, and psychosis with a high mortality rate. In this paper, we present a case report of mild encephalitis with reversible splenial lesion clinically presenting as delirious mania and evolving into life-threatening multi-organ failure. The patient was treated with aripiprazole and benzodiazepine with poor effect and, after 4 days, the patient's condition significantly worsened requiring transfer to the intensive care unit where deep sedation with propofol was started. Our findings are in contrast with the traditional literature description of self-resolving and harmless mild encephalitis with reversible splenial lesion. Moreover, rapid clinical recovery and the progressive improvement of psychiatric symptoms after deep sedation with propofol in this case—considering propofol's neuroprotective and anti-inflammatory effects—supports the notion of propofol-mediated deep sedation for the treatment of severe manic symptoms associated with life-threatening conditions. Little is known about neural markers of the manic state, and the corpus callosum has been described to be involved in bipolar disorder. Abnormalities in this structure may represent a marker of vulnerability for this disorder.
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title_short	Adult Mild Encephalitis With Reversible Splenial Lesion Associated With Delirious Mania: A Case Report
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Adult Mild Encephalitis With Reversible Splenial Lesion Associated With Delirious Mania: A Case Report

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