Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer

Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains a serious concern due to the limitations associated with currently available cancer management strate...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sosmitha Girisa [verfasserIn] Dey Parama [verfasserIn] Choudhary Harsha [verfasserIn] Kishore Banik [verfasserIn] Ajaikumar B. Kunnumakkara [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	cancer commiphora wightii guggulsterone z and e isomers anticancer activities

Übergeordnetes Werk:	In: Exploration of Targeted Anti-tumor Therapy - Open Exploration Publishing Inc., 2021, 1(2020), 5, Seite 313-342
Übergeordnetes Werk:	volume:1 ; year:2020 ; number:5 ; pages:313-342

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.37349/etat.2020.00019

Katalog-ID:	DOAJ001809911

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callnumber-first	R - Medicine
author	Sosmitha Girisa
spellingShingle	Sosmitha Girisa misc RC31-1245 misc cancer misc commiphora wightii misc guggulsterone misc z and e isomers misc anticancer activities misc Internal medicine Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer
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topic_title	RC31-1245 Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer cancer commiphora wightii guggulsterone z and e isomers anticancer activities
topic	misc RC31-1245 misc cancer misc commiphora wightii misc guggulsterone misc z and e isomers misc anticancer activities misc Internal medicine
topic_unstemmed	misc RC31-1245 misc cancer misc commiphora wightii misc guggulsterone misc z and e isomers misc anticancer activities misc Internal medicine
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title	Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer
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title_full	Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer
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title_sort	potential of guggulsterone, a farnesoid x receptor antagonist, in the prevention and treatment of cancer
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title_auth	Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer
abstract	Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains a serious concern due to the limitations associated with currently available cancer management strategies. Therefore, alternative strategies are highly required to overcome these glitches. The importance of medicinal plants as primary healthcare has been well-known from time immemorial against various human diseases, including cancer. Commiphora wightii that belongs to Burseraceae family is one such plant which has been used to cure various ailments in traditional systems of medicine. This plant has diverse pharmacological properties such as antioxidant, antibacterial, antimutagenic, and antitumor which mostly owes to the presence of its active compound guggulsterone (GS) that exists in the form of Z- and E-isomers. Mounting evidence suggests that this compound has promising anticancer activities and was shown to suppress several cancer signaling pathways such as NF-κB/ERK/MAPK/AKT/STAT and modulate the expression of numerous signaling molecules such as the farnesoid X receptor, cyclin D1, survivin, caspases, HIF-1α, MMP-9, EMT proteins, tumor suppressor proteins, angiogenic proteins, and apoptotic proteins. The current review is an attempt to summarize the biological activities and diverse anticancer activities (both in vitro and in vivo) of the compound GS and its derivatives, along with its associated mechanism against various cancers.
abstractGer	Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains a serious concern due to the limitations associated with currently available cancer management strategies. Therefore, alternative strategies are highly required to overcome these glitches. The importance of medicinal plants as primary healthcare has been well-known from time immemorial against various human diseases, including cancer. Commiphora wightii that belongs to Burseraceae family is one such plant which has been used to cure various ailments in traditional systems of medicine. This plant has diverse pharmacological properties such as antioxidant, antibacterial, antimutagenic, and antitumor which mostly owes to the presence of its active compound guggulsterone (GS) that exists in the form of Z- and E-isomers. Mounting evidence suggests that this compound has promising anticancer activities and was shown to suppress several cancer signaling pathways such as NF-κB/ERK/MAPK/AKT/STAT and modulate the expression of numerous signaling molecules such as the farnesoid X receptor, cyclin D1, survivin, caspases, HIF-1α, MMP-9, EMT proteins, tumor suppressor proteins, angiogenic proteins, and apoptotic proteins. The current review is an attempt to summarize the biological activities and diverse anticancer activities (both in vitro and in vivo) of the compound GS and its derivatives, along with its associated mechanism against various cancers.
abstract_unstemmed	Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains a serious concern due to the limitations associated with currently available cancer management strategies. Therefore, alternative strategies are highly required to overcome these glitches. The importance of medicinal plants as primary healthcare has been well-known from time immemorial against various human diseases, including cancer. Commiphora wightii that belongs to Burseraceae family is one such plant which has been used to cure various ailments in traditional systems of medicine. This plant has diverse pharmacological properties such as antioxidant, antibacterial, antimutagenic, and antitumor which mostly owes to the presence of its active compound guggulsterone (GS) that exists in the form of Z- and E-isomers. Mounting evidence suggests that this compound has promising anticancer activities and was shown to suppress several cancer signaling pathways such as NF-κB/ERK/MAPK/AKT/STAT and modulate the expression of numerous signaling molecules such as the farnesoid X receptor, cyclin D1, survivin, caspases, HIF-1α, MMP-9, EMT proteins, tumor suppressor proteins, angiogenic proteins, and apoptotic proteins. The current review is an attempt to summarize the biological activities and diverse anticancer activities (both in vitro and in vivo) of the compound GS and its derivatives, along with its associated mechanism against various cancers.
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title_short	Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer
url	https://doi.org/10.37349/etat.2020.00019 https://doaj.org/article/f4acd93035384289aaa12ac9fa80ed90 https://www.explorationpub.com/Journals/etat/Article/100219 https://doaj.org/toc/2692-3114
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up_date	2024-07-03T22:30:47.994Z
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Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer

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