The effect of interleukin-10 and transforming growth factor β-1 on HLA-DR expression in colonic epithelial cells

The aim of this study was to assess whether interleukin-10 (IL-10) and/or transforming growth factor β-1 (TGF β1) downregulate HLA-DR expression using the HT29 cell line as a model of colonic epithelial cells. HLA-DR expression was induced in HT29 cells with γ-interferon. The effects of IL-10 alone,...
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Gespeichert in:

Autor*in:	M. J. Zimmerman [verfasserIn] G. R. Radford-Smith [verfasserIn] D. P. Jewell [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	1998

Schlagwörter:	InterLeukin-10 Transforming Growth Factor β1 γ-Interferon HLA-DR HT29 Cell Culture.

Übergeordnetes Werk:	In: Mediators of Inflammation - Hindawi Limited, 2002, 7(1998), 1, Seite 7-11
Übergeordnetes Werk:	volume:7 ; year:1998 ; number:1 ; pages:7-11

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/09629359891315

Katalog-ID:	DOAJ001883070

Internformat


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245	1	4	\|a The effect of interleukin-10 and transforming growth factor β-1 on HLA-DR expression in colonic epithelial cells
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520			\|a The aim of this study was to assess whether interleukin-10 (IL-10) and/or transforming growth factor β-1 (TGF β1) downregulate HLA-DR expression using the HT29 cell line as a model of colonic epithelial cells. HLA-DR expression was induced in HT29 cells with γ-interferon. The effects of IL-10 alone, TGF β1 alone, and IL-10 and TGF β1 in combination were studied. HLA-DR expression was assessed using flow cytometric analysis. γ-Interferon induced HLA-DR expression in a dose-dependent fashion. In the absence of γ-interferon, neither IL-10 nor TGF β1 induced HLA-DR expression. In isolation, neither IL10 nor TGF β1 downregulated HLA-DR expression. When IL-10 and TGF β1 were added in combination, small (6-30%) statistically significant reductions in HLA-DR expression were seen. The biological significance is unclear.
650		4	\|a InterLeukin-10
650		4	\|a Transforming Growth Factor β1
650		4	\|a γ-Interferon
650		4	\|a HLA-DR
650		4	\|a HT29 Cell Culture.
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912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4336
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 7 \|j 1998 \|e 1 \|h 7-11

Indexfelder

author_variant	m j z mjz g r r s grrs d p j dpj
matchkey_str	article:14661861:1998----::hefcoitrekn0ntasomngotfco1nldepeso
hierarchy_sort_str	1998
callnumber-subject-code	RB
publishDate	1998
allfields	10.1080/09629359891315 doi (DE-627)DOAJ001883070 (DE-599)DOAJdb7cd60af0c54c57a536f24a2d766b23 DE-627 ger DE-627 rakwb eng RB1-214 M. J. Zimmerman verfasserin aut The effect of interleukin-10 and transforming growth factor β-1 on HLA-DR expression in colonic epithelial cells 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to assess whether interleukin-10 (IL-10) and/or transforming growth factor β-1 (TGF β1) downregulate HLA-DR expression using the HT29 cell line as a model of colonic epithelial cells. HLA-DR expression was induced in HT29 cells with γ-interferon. The effects of IL-10 alone, TGF β1 alone, and IL-10 and TGF β1 in combination were studied. HLA-DR expression was assessed using flow cytometric analysis. γ-Interferon induced HLA-DR expression in a dose-dependent fashion. In the absence of γ-interferon, neither IL-10 nor TGF β1 induced HLA-DR expression. In isolation, neither IL10 nor TGF β1 downregulated HLA-DR expression. When IL-10 and TGF β1 were added in combination, small (6-30%) statistically significant reductions in HLA-DR expression were seen. The biological significance is unclear. InterLeukin-10 Transforming Growth Factor β1 γ-Interferon HLA-DR HT29 Cell Culture. Pathology G. R. Radford-Smith verfasserin aut D. P. Jewell verfasserin aut In Mediators of Inflammation Hindawi Limited, 2002 7(1998), 1, Seite 7-11 (DE-627)320467384 (DE-600)2008065-7 14661861 nnns volume:7 year:1998 number:1 pages:7-11 https://doi.org/10.1080/09629359891315 kostenfrei https://doaj.org/article/db7cd60af0c54c57a536f24a2d766b23 kostenfrei http://dx.doi.org/10.1080/09629359891315 kostenfrei https://doaj.org/toc/0962-9351 Journal toc kostenfrei https://doaj.org/toc/1466-1861 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 1998 1 7-11
spelling	10.1080/09629359891315 doi (DE-627)DOAJ001883070 (DE-599)DOAJdb7cd60af0c54c57a536f24a2d766b23 DE-627 ger DE-627 rakwb eng RB1-214 M. J. Zimmerman verfasserin aut The effect of interleukin-10 and transforming growth factor β-1 on HLA-DR expression in colonic epithelial cells 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to assess whether interleukin-10 (IL-10) and/or transforming growth factor β-1 (TGF β1) downregulate HLA-DR expression using the HT29 cell line as a model of colonic epithelial cells. HLA-DR expression was induced in HT29 cells with γ-interferon. The effects of IL-10 alone, TGF β1 alone, and IL-10 and TGF β1 in combination were studied. HLA-DR expression was assessed using flow cytometric analysis. γ-Interferon induced HLA-DR expression in a dose-dependent fashion. In the absence of γ-interferon, neither IL-10 nor TGF β1 induced HLA-DR expression. In isolation, neither IL10 nor TGF β1 downregulated HLA-DR expression. When IL-10 and TGF β1 were added in combination, small (6-30%) statistically significant reductions in HLA-DR expression were seen. The biological significance is unclear. InterLeukin-10 Transforming Growth Factor β1 γ-Interferon HLA-DR HT29 Cell Culture. Pathology G. R. Radford-Smith verfasserin aut D. P. Jewell verfasserin aut In Mediators of Inflammation Hindawi Limited, 2002 7(1998), 1, Seite 7-11 (DE-627)320467384 (DE-600)2008065-7 14661861 nnns volume:7 year:1998 number:1 pages:7-11 https://doi.org/10.1080/09629359891315 kostenfrei https://doaj.org/article/db7cd60af0c54c57a536f24a2d766b23 kostenfrei http://dx.doi.org/10.1080/09629359891315 kostenfrei https://doaj.org/toc/0962-9351 Journal toc kostenfrei https://doaj.org/toc/1466-1861 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 1998 1 7-11
allfields_unstemmed	10.1080/09629359891315 doi (DE-627)DOAJ001883070 (DE-599)DOAJdb7cd60af0c54c57a536f24a2d766b23 DE-627 ger DE-627 rakwb eng RB1-214 M. J. Zimmerman verfasserin aut The effect of interleukin-10 and transforming growth factor β-1 on HLA-DR expression in colonic epithelial cells 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to assess whether interleukin-10 (IL-10) and/or transforming growth factor β-1 (TGF β1) downregulate HLA-DR expression using the HT29 cell line as a model of colonic epithelial cells. HLA-DR expression was induced in HT29 cells with γ-interferon. The effects of IL-10 alone, TGF β1 alone, and IL-10 and TGF β1 in combination were studied. HLA-DR expression was assessed using flow cytometric analysis. γ-Interferon induced HLA-DR expression in a dose-dependent fashion. In the absence of γ-interferon, neither IL-10 nor TGF β1 induced HLA-DR expression. In isolation, neither IL10 nor TGF β1 downregulated HLA-DR expression. When IL-10 and TGF β1 were added in combination, small (6-30%) statistically significant reductions in HLA-DR expression were seen. The biological significance is unclear. InterLeukin-10 Transforming Growth Factor β1 γ-Interferon HLA-DR HT29 Cell Culture. Pathology G. R. Radford-Smith verfasserin aut D. P. Jewell verfasserin aut In Mediators of Inflammation Hindawi Limited, 2002 7(1998), 1, Seite 7-11 (DE-627)320467384 (DE-600)2008065-7 14661861 nnns volume:7 year:1998 number:1 pages:7-11 https://doi.org/10.1080/09629359891315 kostenfrei https://doaj.org/article/db7cd60af0c54c57a536f24a2d766b23 kostenfrei http://dx.doi.org/10.1080/09629359891315 kostenfrei https://doaj.org/toc/0962-9351 Journal toc kostenfrei https://doaj.org/toc/1466-1861 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 1998 1 7-11
allfieldsGer	10.1080/09629359891315 doi (DE-627)DOAJ001883070 (DE-599)DOAJdb7cd60af0c54c57a536f24a2d766b23 DE-627 ger DE-627 rakwb eng RB1-214 M. J. Zimmerman verfasserin aut The effect of interleukin-10 and transforming growth factor β-1 on HLA-DR expression in colonic epithelial cells 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to assess whether interleukin-10 (IL-10) and/or transforming growth factor β-1 (TGF β1) downregulate HLA-DR expression using the HT29 cell line as a model of colonic epithelial cells. HLA-DR expression was induced in HT29 cells with γ-interferon. The effects of IL-10 alone, TGF β1 alone, and IL-10 and TGF β1 in combination were studied. HLA-DR expression was assessed using flow cytometric analysis. γ-Interferon induced HLA-DR expression in a dose-dependent fashion. In the absence of γ-interferon, neither IL-10 nor TGF β1 induced HLA-DR expression. In isolation, neither IL10 nor TGF β1 downregulated HLA-DR expression. When IL-10 and TGF β1 were added in combination, small (6-30%) statistically significant reductions in HLA-DR expression were seen. The biological significance is unclear. InterLeukin-10 Transforming Growth Factor β1 γ-Interferon HLA-DR HT29 Cell Culture. Pathology G. R. Radford-Smith verfasserin aut D. P. Jewell verfasserin aut In Mediators of Inflammation Hindawi Limited, 2002 7(1998), 1, Seite 7-11 (DE-627)320467384 (DE-600)2008065-7 14661861 nnns volume:7 year:1998 number:1 pages:7-11 https://doi.org/10.1080/09629359891315 kostenfrei https://doaj.org/article/db7cd60af0c54c57a536f24a2d766b23 kostenfrei http://dx.doi.org/10.1080/09629359891315 kostenfrei https://doaj.org/toc/0962-9351 Journal toc kostenfrei https://doaj.org/toc/1466-1861 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 1998 1 7-11
allfieldsSound	10.1080/09629359891315 doi (DE-627)DOAJ001883070 (DE-599)DOAJdb7cd60af0c54c57a536f24a2d766b23 DE-627 ger DE-627 rakwb eng RB1-214 M. J. Zimmerman verfasserin aut The effect of interleukin-10 and transforming growth factor β-1 on HLA-DR expression in colonic epithelial cells 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to assess whether interleukin-10 (IL-10) and/or transforming growth factor β-1 (TGF β1) downregulate HLA-DR expression using the HT29 cell line as a model of colonic epithelial cells. HLA-DR expression was induced in HT29 cells with γ-interferon. The effects of IL-10 alone, TGF β1 alone, and IL-10 and TGF β1 in combination were studied. HLA-DR expression was assessed using flow cytometric analysis. γ-Interferon induced HLA-DR expression in a dose-dependent fashion. In the absence of γ-interferon, neither IL-10 nor TGF β1 induced HLA-DR expression. In isolation, neither IL10 nor TGF β1 downregulated HLA-DR expression. When IL-10 and TGF β1 were added in combination, small (6-30%) statistically significant reductions in HLA-DR expression were seen. The biological significance is unclear. InterLeukin-10 Transforming Growth Factor β1 γ-Interferon HLA-DR HT29 Cell Culture. Pathology G. R. Radford-Smith verfasserin aut D. P. Jewell verfasserin aut In Mediators of Inflammation Hindawi Limited, 2002 7(1998), 1, Seite 7-11 (DE-627)320467384 (DE-600)2008065-7 14661861 nnns volume:7 year:1998 number:1 pages:7-11 https://doi.org/10.1080/09629359891315 kostenfrei https://doaj.org/article/db7cd60af0c54c57a536f24a2d766b23 kostenfrei http://dx.doi.org/10.1080/09629359891315 kostenfrei https://doaj.org/toc/0962-9351 Journal toc kostenfrei https://doaj.org/toc/1466-1861 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 1998 1 7-11
language	English
source	In Mediators of Inflammation 7(1998), 1, Seite 7-11 volume:7 year:1998 number:1 pages:7-11
sourceStr	In Mediators of Inflammation 7(1998), 1, Seite 7-11 volume:7 year:1998 number:1 pages:7-11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	InterLeukin-10 Transforming Growth Factor β1 γ-Interferon HLA-DR HT29 Cell Culture. Pathology
isfreeaccess_bool	true
container_title	Mediators of Inflammation
authorswithroles_txt_mv	M. J. Zimmerman @@aut@@ G. R. Radford-Smith @@aut@@ D. P. Jewell @@aut@@
publishDateDaySort_date	1998-01-01T00:00:00Z
hierarchy_top_id	320467384
id	DOAJ001883070
language_de	englisch
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callnumber-first	R - Medicine
author	M. J. Zimmerman
spellingShingle	M. J. Zimmerman misc RB1-214 misc InterLeukin-10 misc Transforming Growth Factor β1 misc γ-Interferon misc HLA-DR misc HT29 Cell Culture. misc Pathology The effect of interleukin-10 and transforming growth factor β-1 on HLA-DR expression in colonic epithelial cells
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topic_title	RB1-214 The effect of interleukin-10 and transforming growth factor β-1 on HLA-DR expression in colonic epithelial cells InterLeukin-10 Transforming Growth Factor β1 γ-Interferon HLA-DR HT29 Cell Culture
topic	misc RB1-214 misc InterLeukin-10 misc Transforming Growth Factor β1 misc γ-Interferon misc HLA-DR misc HT29 Cell Culture. misc Pathology
topic_unstemmed	misc RB1-214 misc InterLeukin-10 misc Transforming Growth Factor β1 misc γ-Interferon misc HLA-DR misc HT29 Cell Culture. misc Pathology
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title	The effect of interleukin-10 and transforming growth factor β-1 on HLA-DR expression in colonic epithelial cells
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title_full	The effect of interleukin-10 and transforming growth factor β-1 on HLA-DR expression in colonic epithelial cells
author_sort	M. J. Zimmerman
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author_browse	M. J. Zimmerman G. R. Radford-Smith D. P. Jewell
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title_sort	effect of interleukin-10 and transforming growth factor β-1 on hla-dr expression in colonic epithelial cells
callnumber	RB1-214
title_auth	The effect of interleukin-10 and transforming growth factor β-1 on HLA-DR expression in colonic epithelial cells
abstract	The aim of this study was to assess whether interleukin-10 (IL-10) and/or transforming growth factor β-1 (TGF β1) downregulate HLA-DR expression using the HT29 cell line as a model of colonic epithelial cells. HLA-DR expression was induced in HT29 cells with γ-interferon. The effects of IL-10 alone, TGF β1 alone, and IL-10 and TGF β1 in combination were studied. HLA-DR expression was assessed using flow cytometric analysis. γ-Interferon induced HLA-DR expression in a dose-dependent fashion. In the absence of γ-interferon, neither IL-10 nor TGF β1 induced HLA-DR expression. In isolation, neither IL10 nor TGF β1 downregulated HLA-DR expression. When IL-10 and TGF β1 were added in combination, small (6-30%) statistically significant reductions in HLA-DR expression were seen. The biological significance is unclear.
abstractGer	The aim of this study was to assess whether interleukin-10 (IL-10) and/or transforming growth factor β-1 (TGF β1) downregulate HLA-DR expression using the HT29 cell line as a model of colonic epithelial cells. HLA-DR expression was induced in HT29 cells with γ-interferon. The effects of IL-10 alone, TGF β1 alone, and IL-10 and TGF β1 in combination were studied. HLA-DR expression was assessed using flow cytometric analysis. γ-Interferon induced HLA-DR expression in a dose-dependent fashion. In the absence of γ-interferon, neither IL-10 nor TGF β1 induced HLA-DR expression. In isolation, neither IL10 nor TGF β1 downregulated HLA-DR expression. When IL-10 and TGF β1 were added in combination, small (6-30%) statistically significant reductions in HLA-DR expression were seen. The biological significance is unclear.
abstract_unstemmed	The aim of this study was to assess whether interleukin-10 (IL-10) and/or transforming growth factor β-1 (TGF β1) downregulate HLA-DR expression using the HT29 cell line as a model of colonic epithelial cells. HLA-DR expression was induced in HT29 cells with γ-interferon. The effects of IL-10 alone, TGF β1 alone, and IL-10 and TGF β1 in combination were studied. HLA-DR expression was assessed using flow cytometric analysis. γ-Interferon induced HLA-DR expression in a dose-dependent fashion. In the absence of γ-interferon, neither IL-10 nor TGF β1 induced HLA-DR expression. In isolation, neither IL10 nor TGF β1 downregulated HLA-DR expression. When IL-10 and TGF β1 were added in combination, small (6-30%) statistically significant reductions in HLA-DR expression were seen. The biological significance is unclear.
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title_short	The effect of interleukin-10 and transforming growth factor β-1 on HLA-DR expression in colonic epithelial cells
url	https://doi.org/10.1080/09629359891315 https://doaj.org/article/db7cd60af0c54c57a536f24a2d766b23 http://dx.doi.org/10.1080/09629359891315 https://doaj.org/toc/0962-9351 https://doaj.org/toc/1466-1861
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HLA-DR expression was induced in HT29 cells with γ-interferon. The effects of IL-10 alone, TGF β1 alone, and IL-10 and TGF β1 in combination were studied. HLA-DR expression was assessed using flow cytometric analysis. γ-Interferon induced HLA-DR expression in a dose-dependent fashion. In the absence of γ-interferon, neither IL-10 nor TGF β1 induced HLA-DR expression. In isolation, neither IL10 nor TGF β1 downregulated HLA-DR expression. When IL-10 and TGF β1 were added in combination, small (6-30%) statistically significant reductions in HLA-DR expression were seen. 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The effect of interleukin-10 and transforming growth factor β-1 on HLA-DR expression in colonic epithelial cells

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