Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History

Background and objectives: Esophageal cancer (EC) is the second most common gastrointestinal cancer, and esophageal squamous cell carcinoma (ESCC) is the dominant type of EC in Iran. One of the most important challenges in cancer management is the early diagnosis. As tumor suppressors or oncogenes,...
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Autor*in:	Halime Rahimnia [verfasserIn] Abdolvahab Moradi [verfasserIn] Naemeh Javid [verfasserIn] Yasaman Fateri [verfasserIn] Shabbou Bahramian [verfasserIn] Zahra Roohinejad [verfasserIn] Hossein Sabouri [verfasserIn] Eisa Jorjani [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	esophageal cancer escc lncrna lnc-pou3f3

Übergeordnetes Werk:	In: Journal of Clinical and Basic Research - Golestan University Of Medical Sciences, 2018, 2(2018), 4, Seite 48-53
Übergeordnetes Werk:	volume:2 ; year:2018 ; number:4 ; pages:48-53

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ001924079

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520			\|a Background and objectives: Esophageal cancer (EC) is the second most common gastrointestinal cancer, and esophageal squamous cell carcinoma (ESCC) is the dominant type of EC in Iran. One of the most important challenges in cancer management is the early diagnosis. As tumor suppressors or oncogenes, long non-coding RNAs (lncRNAs) play a vital role in tumor initiation, progression and metastasis. Recent studies have reported dysregulated expression of lncRNAs in different tumor tissues including ESCC, which may indicate its prognostic or diagnostic potential in ESCC. In this study, we investigated expression pattern of lnc-POU3F3 in ESCC. Methods: We performed quantitative real-time polymerase chain reaction to assess lnc-POU3F3 expression pattern in ESCC blood samples from 32 patients with ESCC and age- and sex-matched healthy controls. Results: Lnc-POU3F3 was significantly overexpressed in ESCC blood samples compared to normal samples. In addition, this overexpression had a significant correlation with family history (P=0.03) and TNM stage (P=0.02). Conclusion: According to the findings of the present study, lnc-POU3F3 may be used as a diagnostic biomarker for ESCC. However, studies with a larger sample size should be carried out to confirm this finding.
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allfields	(DE-627)DOAJ001924079 (DE-599)DOAJ9c70c0e8541a4b1896da366b607f03a2 DE-627 ger DE-627 rakwb eng RC31-1245 Halime Rahimnia verfasserin aut Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and objectives: Esophageal cancer (EC) is the second most common gastrointestinal cancer, and esophageal squamous cell carcinoma (ESCC) is the dominant type of EC in Iran. One of the most important challenges in cancer management is the early diagnosis. As tumor suppressors or oncogenes, long non-coding RNAs (lncRNAs) play a vital role in tumor initiation, progression and metastasis. Recent studies have reported dysregulated expression of lncRNAs in different tumor tissues including ESCC, which may indicate its prognostic or diagnostic potential in ESCC. In this study, we investigated expression pattern of lnc-POU3F3 in ESCC. Methods: We performed quantitative real-time polymerase chain reaction to assess lnc-POU3F3 expression pattern in ESCC blood samples from 32 patients with ESCC and age- and sex-matched healthy controls. Results: Lnc-POU3F3 was significantly overexpressed in ESCC blood samples compared to normal samples. In addition, this overexpression had a significant correlation with family history (P=0.03) and TNM stage (P=0.02). Conclusion: According to the findings of the present study, lnc-POU3F3 may be used as a diagnostic biomarker for ESCC. However, studies with a larger sample size should be carried out to confirm this finding. esophageal cancer escc lncrna lnc-pou3f3 Internal medicine Abdolvahab Moradi verfasserin aut Naemeh Javid verfasserin aut Yasaman Fateri verfasserin aut Shabbou Bahramian verfasserin aut Zahra Roohinejad verfasserin aut Hossein Sabouri verfasserin aut Eisa Jorjani verfasserin aut In Journal of Clinical and Basic Research Golestan University Of Medical Sciences, 2018 2(2018), 4, Seite 48-53 (DE-627)1692698583 25383736 nnns volume:2 year:2018 number:4 pages:48-53 https://doaj.org/article/9c70c0e8541a4b1896da366b607f03a2 kostenfrei http://jcbr.goums.ac.ir/article-1-168-en.html kostenfrei https://doaj.org/toc/2538-3736 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2018 4 48-53
spelling	(DE-627)DOAJ001924079 (DE-599)DOAJ9c70c0e8541a4b1896da366b607f03a2 DE-627 ger DE-627 rakwb eng RC31-1245 Halime Rahimnia verfasserin aut Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and objectives: Esophageal cancer (EC) is the second most common gastrointestinal cancer, and esophageal squamous cell carcinoma (ESCC) is the dominant type of EC in Iran. One of the most important challenges in cancer management is the early diagnosis. As tumor suppressors or oncogenes, long non-coding RNAs (lncRNAs) play a vital role in tumor initiation, progression and metastasis. Recent studies have reported dysregulated expression of lncRNAs in different tumor tissues including ESCC, which may indicate its prognostic or diagnostic potential in ESCC. In this study, we investigated expression pattern of lnc-POU3F3 in ESCC. Methods: We performed quantitative real-time polymerase chain reaction to assess lnc-POU3F3 expression pattern in ESCC blood samples from 32 patients with ESCC and age- and sex-matched healthy controls. Results: Lnc-POU3F3 was significantly overexpressed in ESCC blood samples compared to normal samples. In addition, this overexpression had a significant correlation with family history (P=0.03) and TNM stage (P=0.02). Conclusion: According to the findings of the present study, lnc-POU3F3 may be used as a diagnostic biomarker for ESCC. However, studies with a larger sample size should be carried out to confirm this finding. esophageal cancer escc lncrna lnc-pou3f3 Internal medicine Abdolvahab Moradi verfasserin aut Naemeh Javid verfasserin aut Yasaman Fateri verfasserin aut Shabbou Bahramian verfasserin aut Zahra Roohinejad verfasserin aut Hossein Sabouri verfasserin aut Eisa Jorjani verfasserin aut In Journal of Clinical and Basic Research Golestan University Of Medical Sciences, 2018 2(2018), 4, Seite 48-53 (DE-627)1692698583 25383736 nnns volume:2 year:2018 number:4 pages:48-53 https://doaj.org/article/9c70c0e8541a4b1896da366b607f03a2 kostenfrei http://jcbr.goums.ac.ir/article-1-168-en.html kostenfrei https://doaj.org/toc/2538-3736 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2018 4 48-53
allfields_unstemmed	(DE-627)DOAJ001924079 (DE-599)DOAJ9c70c0e8541a4b1896da366b607f03a2 DE-627 ger DE-627 rakwb eng RC31-1245 Halime Rahimnia verfasserin aut Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and objectives: Esophageal cancer (EC) is the second most common gastrointestinal cancer, and esophageal squamous cell carcinoma (ESCC) is the dominant type of EC in Iran. One of the most important challenges in cancer management is the early diagnosis. As tumor suppressors or oncogenes, long non-coding RNAs (lncRNAs) play a vital role in tumor initiation, progression and metastasis. Recent studies have reported dysregulated expression of lncRNAs in different tumor tissues including ESCC, which may indicate its prognostic or diagnostic potential in ESCC. In this study, we investigated expression pattern of lnc-POU3F3 in ESCC. Methods: We performed quantitative real-time polymerase chain reaction to assess lnc-POU3F3 expression pattern in ESCC blood samples from 32 patients with ESCC and age- and sex-matched healthy controls. Results: Lnc-POU3F3 was significantly overexpressed in ESCC blood samples compared to normal samples. In addition, this overexpression had a significant correlation with family history (P=0.03) and TNM stage (P=0.02). Conclusion: According to the findings of the present study, lnc-POU3F3 may be used as a diagnostic biomarker for ESCC. However, studies with a larger sample size should be carried out to confirm this finding. esophageal cancer escc lncrna lnc-pou3f3 Internal medicine Abdolvahab Moradi verfasserin aut Naemeh Javid verfasserin aut Yasaman Fateri verfasserin aut Shabbou Bahramian verfasserin aut Zahra Roohinejad verfasserin aut Hossein Sabouri verfasserin aut Eisa Jorjani verfasserin aut In Journal of Clinical and Basic Research Golestan University Of Medical Sciences, 2018 2(2018), 4, Seite 48-53 (DE-627)1692698583 25383736 nnns volume:2 year:2018 number:4 pages:48-53 https://doaj.org/article/9c70c0e8541a4b1896da366b607f03a2 kostenfrei http://jcbr.goums.ac.ir/article-1-168-en.html kostenfrei https://doaj.org/toc/2538-3736 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2018 4 48-53
allfieldsGer	(DE-627)DOAJ001924079 (DE-599)DOAJ9c70c0e8541a4b1896da366b607f03a2 DE-627 ger DE-627 rakwb eng RC31-1245 Halime Rahimnia verfasserin aut Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and objectives: Esophageal cancer (EC) is the second most common gastrointestinal cancer, and esophageal squamous cell carcinoma (ESCC) is the dominant type of EC in Iran. One of the most important challenges in cancer management is the early diagnosis. As tumor suppressors or oncogenes, long non-coding RNAs (lncRNAs) play a vital role in tumor initiation, progression and metastasis. Recent studies have reported dysregulated expression of lncRNAs in different tumor tissues including ESCC, which may indicate its prognostic or diagnostic potential in ESCC. In this study, we investigated expression pattern of lnc-POU3F3 in ESCC. Methods: We performed quantitative real-time polymerase chain reaction to assess lnc-POU3F3 expression pattern in ESCC blood samples from 32 patients with ESCC and age- and sex-matched healthy controls. Results: Lnc-POU3F3 was significantly overexpressed in ESCC blood samples compared to normal samples. In addition, this overexpression had a significant correlation with family history (P=0.03) and TNM stage (P=0.02). Conclusion: According to the findings of the present study, lnc-POU3F3 may be used as a diagnostic biomarker for ESCC. However, studies with a larger sample size should be carried out to confirm this finding. esophageal cancer escc lncrna lnc-pou3f3 Internal medicine Abdolvahab Moradi verfasserin aut Naemeh Javid verfasserin aut Yasaman Fateri verfasserin aut Shabbou Bahramian verfasserin aut Zahra Roohinejad verfasserin aut Hossein Sabouri verfasserin aut Eisa Jorjani verfasserin aut In Journal of Clinical and Basic Research Golestan University Of Medical Sciences, 2018 2(2018), 4, Seite 48-53 (DE-627)1692698583 25383736 nnns volume:2 year:2018 number:4 pages:48-53 https://doaj.org/article/9c70c0e8541a4b1896da366b607f03a2 kostenfrei http://jcbr.goums.ac.ir/article-1-168-en.html kostenfrei https://doaj.org/toc/2538-3736 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2018 4 48-53
allfieldsSound	(DE-627)DOAJ001924079 (DE-599)DOAJ9c70c0e8541a4b1896da366b607f03a2 DE-627 ger DE-627 rakwb eng RC31-1245 Halime Rahimnia verfasserin aut Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and objectives: Esophageal cancer (EC) is the second most common gastrointestinal cancer, and esophageal squamous cell carcinoma (ESCC) is the dominant type of EC in Iran. One of the most important challenges in cancer management is the early diagnosis. As tumor suppressors or oncogenes, long non-coding RNAs (lncRNAs) play a vital role in tumor initiation, progression and metastasis. Recent studies have reported dysregulated expression of lncRNAs in different tumor tissues including ESCC, which may indicate its prognostic or diagnostic potential in ESCC. In this study, we investigated expression pattern of lnc-POU3F3 in ESCC. Methods: We performed quantitative real-time polymerase chain reaction to assess lnc-POU3F3 expression pattern in ESCC blood samples from 32 patients with ESCC and age- and sex-matched healthy controls. Results: Lnc-POU3F3 was significantly overexpressed in ESCC blood samples compared to normal samples. In addition, this overexpression had a significant correlation with family history (P=0.03) and TNM stage (P=0.02). Conclusion: According to the findings of the present study, lnc-POU3F3 may be used as a diagnostic biomarker for ESCC. However, studies with a larger sample size should be carried out to confirm this finding. esophageal cancer escc lncrna lnc-pou3f3 Internal medicine Abdolvahab Moradi verfasserin aut Naemeh Javid verfasserin aut Yasaman Fateri verfasserin aut Shabbou Bahramian verfasserin aut Zahra Roohinejad verfasserin aut Hossein Sabouri verfasserin aut Eisa Jorjani verfasserin aut In Journal of Clinical and Basic Research Golestan University Of Medical Sciences, 2018 2(2018), 4, Seite 48-53 (DE-627)1692698583 25383736 nnns volume:2 year:2018 number:4 pages:48-53 https://doaj.org/article/9c70c0e8541a4b1896da366b607f03a2 kostenfrei http://jcbr.goums.ac.ir/article-1-168-en.html kostenfrei https://doaj.org/toc/2538-3736 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2018 4 48-53
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source	In Journal of Clinical and Basic Research 2(2018), 4, Seite 48-53 volume:2 year:2018 number:4 pages:48-53
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topic_facet	esophageal cancer escc lncrna lnc-pou3f3 Internal medicine
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container_title	Journal of Clinical and Basic Research
authorswithroles_txt_mv	Halime Rahimnia @@aut@@ Abdolvahab Moradi @@aut@@ Naemeh Javid @@aut@@ Yasaman Fateri @@aut@@ Shabbou Bahramian @@aut@@ Zahra Roohinejad @@aut@@ Hossein Sabouri @@aut@@ Eisa Jorjani @@aut@@
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callnumber-first	R - Medicine
author	Halime Rahimnia
spellingShingle	Halime Rahimnia misc RC31-1245 misc esophageal cancer misc escc misc lncrna misc lnc-pou3f3 misc Internal medicine Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History
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topic_title	RC31-1245 Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History esophageal cancer escc lncrna lnc-pou3f3
topic	misc RC31-1245 misc esophageal cancer misc escc misc lncrna misc lnc-pou3f3 misc Internal medicine
topic_unstemmed	misc RC31-1245 misc esophageal cancer misc escc misc lncrna misc lnc-pou3f3 misc Internal medicine
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title	Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History
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title_full	Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History
author_sort	Halime Rahimnia
journal	Journal of Clinical and Basic Research
journalStr	Journal of Clinical and Basic Research
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author_browse	Halime Rahimnia Abdolvahab Moradi Naemeh Javid Yasaman Fateri Shabbou Bahramian Zahra Roohinejad Hossein Sabouri Eisa Jorjani
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author-letter	Halime Rahimnia
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title_sort	overexpression of long non-coding rna pou3f3 in esophageal squamous cell carcinoma is associated with tnm stage and family history
callnumber	RC31-1245
title_auth	Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History
abstract	Background and objectives: Esophageal cancer (EC) is the second most common gastrointestinal cancer, and esophageal squamous cell carcinoma (ESCC) is the dominant type of EC in Iran. One of the most important challenges in cancer management is the early diagnosis. As tumor suppressors or oncogenes, long non-coding RNAs (lncRNAs) play a vital role in tumor initiation, progression and metastasis. Recent studies have reported dysregulated expression of lncRNAs in different tumor tissues including ESCC, which may indicate its prognostic or diagnostic potential in ESCC. In this study, we investigated expression pattern of lnc-POU3F3 in ESCC. Methods: We performed quantitative real-time polymerase chain reaction to assess lnc-POU3F3 expression pattern in ESCC blood samples from 32 patients with ESCC and age- and sex-matched healthy controls. Results: Lnc-POU3F3 was significantly overexpressed in ESCC blood samples compared to normal samples. In addition, this overexpression had a significant correlation with family history (P=0.03) and TNM stage (P=0.02). Conclusion: According to the findings of the present study, lnc-POU3F3 may be used as a diagnostic biomarker for ESCC. However, studies with a larger sample size should be carried out to confirm this finding.
abstractGer	Background and objectives: Esophageal cancer (EC) is the second most common gastrointestinal cancer, and esophageal squamous cell carcinoma (ESCC) is the dominant type of EC in Iran. One of the most important challenges in cancer management is the early diagnosis. As tumor suppressors or oncogenes, long non-coding RNAs (lncRNAs) play a vital role in tumor initiation, progression and metastasis. Recent studies have reported dysregulated expression of lncRNAs in different tumor tissues including ESCC, which may indicate its prognostic or diagnostic potential in ESCC. In this study, we investigated expression pattern of lnc-POU3F3 in ESCC. Methods: We performed quantitative real-time polymerase chain reaction to assess lnc-POU3F3 expression pattern in ESCC blood samples from 32 patients with ESCC and age- and sex-matched healthy controls. Results: Lnc-POU3F3 was significantly overexpressed in ESCC blood samples compared to normal samples. In addition, this overexpression had a significant correlation with family history (P=0.03) and TNM stage (P=0.02). Conclusion: According to the findings of the present study, lnc-POU3F3 may be used as a diagnostic biomarker for ESCC. However, studies with a larger sample size should be carried out to confirm this finding.
abstract_unstemmed	Background and objectives: Esophageal cancer (EC) is the second most common gastrointestinal cancer, and esophageal squamous cell carcinoma (ESCC) is the dominant type of EC in Iran. One of the most important challenges in cancer management is the early diagnosis. As tumor suppressors or oncogenes, long non-coding RNAs (lncRNAs) play a vital role in tumor initiation, progression and metastasis. Recent studies have reported dysregulated expression of lncRNAs in different tumor tissues including ESCC, which may indicate its prognostic or diagnostic potential in ESCC. In this study, we investigated expression pattern of lnc-POU3F3 in ESCC. Methods: We performed quantitative real-time polymerase chain reaction to assess lnc-POU3F3 expression pattern in ESCC blood samples from 32 patients with ESCC and age- and sex-matched healthy controls. Results: Lnc-POU3F3 was significantly overexpressed in ESCC blood samples compared to normal samples. In addition, this overexpression had a significant correlation with family history (P=0.03) and TNM stage (P=0.02). Conclusion: According to the findings of the present study, lnc-POU3F3 may be used as a diagnostic biomarker for ESCC. However, studies with a larger sample size should be carried out to confirm this finding.
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title_short	Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History
url	https://doaj.org/article/9c70c0e8541a4b1896da366b607f03a2 http://jcbr.goums.ac.ir/article-1-168-en.html https://doaj.org/toc/2538-3736
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author2Str	Abdolvahab Moradi Naemeh Javid Yasaman Fateri Shabbou Bahramian Zahra Roohinejad Hossein Sabouri Eisa Jorjani
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Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History

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