New light on white matter damage of the premature brain: a neonatologist’s point of view

Periventricular leucomalacia (PVL) is traditionally considered a multifactorial lesion related to three main mechanisms: ischemia, inflammation and excitotoxicity. For years it was believed that hypoperfusion, associated with the peculiar vascular anatomy of the premature brain (border zones), was t...
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Gespeichert in:

Autor*in:	Maria Antonietta Marcialis [verfasserIn] Angelica Dessì [verfasserIn] Roberta Irmesi [verfasserIn] Viviana Marinelli [verfasserIn] Maria Cristina Pintus [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Italienisch

Erschienen:	2014

Schlagwörter:	periventricular leucomalacia white matter damage cranial ultrasound very low birth wight outcome neuroprotection

Übergeordnetes Werk:	In: Journal of Pediatric and Neonatal Individualized Medicine - Hygeia Press di Corridori Marinella, 2014, 3(2014), 2, Seite e030237-e030237
Übergeordnetes Werk:	volume:3 ; year:2014 ; number:2 ; pages:e030237-e030237

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.7363/030237

Katalog-ID:	DOAJ001994980

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Proceedings of the International Course on Perinatal Pathology (part of the 10th International Workshop on Neonatology · October 22nd-25th, 2014) · Cagliari (Italy) · October 25th, 2014 · The role of the clinical pathological dialogue in problem solving Guest Editors: Gavino Faa, Vassilios Fanos, Peter Van Eyken</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">periventricular leucomalacia</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">white matter damage</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cranial ultrasound</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">very low birth wight</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">outcome</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">neuroprotection</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield 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topic_title	RJ1-570 New light on white matter damage of the premature brain: a neonatologist’s point of view periventricular leucomalacia white matter damage cranial ultrasound very low birth wight outcome neuroprotection
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title	New light on white matter damage of the premature brain: a neonatologist’s point of view
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title_full	New light on white matter damage of the premature brain: a neonatologist’s point of view
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title_auth	New light on white matter damage of the premature brain: a neonatologist’s point of view
abstract	Periventricular leucomalacia (PVL) is traditionally considered a multifactorial lesion related to three main mechanisms: ischemia, inflammation and excitotoxicity. For years it was believed that hypoperfusion, associated with the peculiar vascular anatomy of the premature brain (border zones), was the conditio sine qua non in the pathogenesis of PVL. More recently this theory has been questioned. Many studies have stressed the importance of the association between inflammation/infection and white matter injury and have supported the multi hit hypothesis according to which several (genetic, hormonal, immune and nutritional) factors may team up in a multi-hit fashion. The emerging concept is that the fetal white cell activation together with the interaction between the innate and adaptive immune system play a main role in white matter damage. Currently there are increasing evidence that PVL is a disease of connectivity. In this article we review the news in the basics of pathogenesis, the incidence, the definition and the diagnosis of PVL. Furthermore, recent follow-up studies and neuroprotective therapies are mentioned. Proceedings of the International Course on Perinatal Pathology (part of the 10th International Workshop on Neonatology · October 22nd-25th, 2014) · Cagliari (Italy) · October 25th, 2014 · The role of the clinical pathological dialogue in problem solving Guest Editors: Gavino Faa, Vassilios Fanos, Peter Van Eyken
abstractGer	Periventricular leucomalacia (PVL) is traditionally considered a multifactorial lesion related to three main mechanisms: ischemia, inflammation and excitotoxicity. For years it was believed that hypoperfusion, associated with the peculiar vascular anatomy of the premature brain (border zones), was the conditio sine qua non in the pathogenesis of PVL. More recently this theory has been questioned. Many studies have stressed the importance of the association between inflammation/infection and white matter injury and have supported the multi hit hypothesis according to which several (genetic, hormonal, immune and nutritional) factors may team up in a multi-hit fashion. The emerging concept is that the fetal white cell activation together with the interaction between the innate and adaptive immune system play a main role in white matter damage. Currently there are increasing evidence that PVL is a disease of connectivity. In this article we review the news in the basics of pathogenesis, the incidence, the definition and the diagnosis of PVL. Furthermore, recent follow-up studies and neuroprotective therapies are mentioned. Proceedings of the International Course on Perinatal Pathology (part of the 10th International Workshop on Neonatology · October 22nd-25th, 2014) · Cagliari (Italy) · October 25th, 2014 · The role of the clinical pathological dialogue in problem solving Guest Editors: Gavino Faa, Vassilios Fanos, Peter Van Eyken
abstract_unstemmed	Periventricular leucomalacia (PVL) is traditionally considered a multifactorial lesion related to three main mechanisms: ischemia, inflammation and excitotoxicity. For years it was believed that hypoperfusion, associated with the peculiar vascular anatomy of the premature brain (border zones), was the conditio sine qua non in the pathogenesis of PVL. More recently this theory has been questioned. Many studies have stressed the importance of the association between inflammation/infection and white matter injury and have supported the multi hit hypothesis according to which several (genetic, hormonal, immune and nutritional) factors may team up in a multi-hit fashion. The emerging concept is that the fetal white cell activation together with the interaction between the innate and adaptive immune system play a main role in white matter damage. Currently there are increasing evidence that PVL is a disease of connectivity. In this article we review the news in the basics of pathogenesis, the incidence, the definition and the diagnosis of PVL. Furthermore, recent follow-up studies and neuroprotective therapies are mentioned. Proceedings of the International Course on Perinatal Pathology (part of the 10th International Workshop on Neonatology · October 22nd-25th, 2014) · Cagliari (Italy) · October 25th, 2014 · The role of the clinical pathological dialogue in problem solving Guest Editors: Gavino Faa, Vassilios Fanos, Peter Van Eyken
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title_short	New light on white matter damage of the premature brain: a neonatologist’s point of view
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