Circulating extracellular vesicles: friends and foes in neurodegeneration

Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological conditions. Via this route, several molecules (e.g., nucleic acids, proteins, metabolites) can be transferred to proximal and distant targets to conve...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Anna Picca [verfasserIn] Flora Guerra [verfasserIn] Riccardo Calvani [verfasserIn] Hélio José Coelho-Junior [verfasserIn] Cecilia Bucci [verfasserIn] Emanuele Marzetti [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	alzheimer’s disease; amyloid protein; exosomes; misfolded proteins; mitochondrial-derived vesicles; neuroinflammation; parkinson’s disease; quality control; tau protein; α-synuclein

Übergeordnetes Werk:	In: Neural Regeneration Research - Wolters Kluwer Medknow Publications, 2014, 17(2022), 3, Seite 534-542
Übergeordnetes Werk:	volume:17 ; year:2022 ; number:3 ; pages:534-542

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.4103/1673-5374.320972

Katalog-ID:	DOAJ002047195

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spelling	10.4103/1673-5374.320972 doi (DE-627)DOAJ002047195 (DE-599)DOAJc29c87aeb20f4aa4ba3e6ed4569af17d DE-627 ger DE-627 rakwb eng RC346-429 Anna Picca verfasserin aut Circulating extracellular vesicles: friends and foes in neurodegeneration 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological conditions. Via this route, several molecules (e.g., nucleic acids, proteins, metabolites) can be transferred to proximal and distant targets to convey specific information. Extracellular vesicle-associated cargo molecules have been proposed as markers of several disease conditions for their potential of tracking down the generating cell. Indeed, circulating extracellular vesicles may represent biomarkers of dysfunctional cellular quality control systems especially in conditions characterized by the accrual of intracellular misfolded proteins. Furthermore, the identification of extracellular vesicles as tools for the delivery of nucleic acids or other cargo molecules to diseased tissues makes these circulating shuttles possible targets for therapeutic development. The increasing interest in the study of extracellular vesicles as biomarkers resides mainly in the fact that the identification of peripheral levels of extracellular vesicle-associated proteins might reflect molecular events occurring in hardly accessible tissues, such as the brain, thereby serving as a “brain liquid biopsy”. The exploitation of extracellular vesicles for diagnostic and therapeutic purposed might offer unprecedented opportunities to develop personalized approaches. Here, we discuss the bright and dark sides of extracellular vesicles in the setting of two main neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). A special focus will be placed on the possibility of using extracellular vesicles as biomarkers for the two conditions to enable disease tracking and treatment monitoring. alzheimer’s disease; amyloid protein; exosomes; misfolded proteins; mitochondrial-derived vesicles; neuroinflammation; parkinson’s disease; quality control; tau protein; α-synuclein Neurology. Diseases of the nervous system Flora Guerra verfasserin aut Riccardo Calvani verfasserin aut Hélio José Coelho-Junior verfasserin aut Cecilia Bucci verfasserin aut Emanuele Marzetti verfasserin aut In Neural Regeneration Research Wolters Kluwer Medknow Publications, 2014 17(2022), 3, Seite 534-542 (DE-627)545785499 (DE-600)2388460-5 18767958 nnns volume:17 year:2022 number:3 pages:534-542 https://doi.org/10.4103/1673-5374.320972 kostenfrei https://doaj.org/article/c29c87aeb20f4aa4ba3e6ed4569af17d kostenfrei http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=3;spage=534;epage=542;aulast=Picca kostenfrei https://doaj.org/toc/1673-5374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2700 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 3 534-542
allfields_unstemmed	10.4103/1673-5374.320972 doi (DE-627)DOAJ002047195 (DE-599)DOAJc29c87aeb20f4aa4ba3e6ed4569af17d DE-627 ger DE-627 rakwb eng RC346-429 Anna Picca verfasserin aut Circulating extracellular vesicles: friends and foes in neurodegeneration 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological conditions. Via this route, several molecules (e.g., nucleic acids, proteins, metabolites) can be transferred to proximal and distant targets to convey specific information. Extracellular vesicle-associated cargo molecules have been proposed as markers of several disease conditions for their potential of tracking down the generating cell. Indeed, circulating extracellular vesicles may represent biomarkers of dysfunctional cellular quality control systems especially in conditions characterized by the accrual of intracellular misfolded proteins. Furthermore, the identification of extracellular vesicles as tools for the delivery of nucleic acids or other cargo molecules to diseased tissues makes these circulating shuttles possible targets for therapeutic development. The increasing interest in the study of extracellular vesicles as biomarkers resides mainly in the fact that the identification of peripheral levels of extracellular vesicle-associated proteins might reflect molecular events occurring in hardly accessible tissues, such as the brain, thereby serving as a “brain liquid biopsy”. The exploitation of extracellular vesicles for diagnostic and therapeutic purposed might offer unprecedented opportunities to develop personalized approaches. Here, we discuss the bright and dark sides of extracellular vesicles in the setting of two main neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). A special focus will be placed on the possibility of using extracellular vesicles as biomarkers for the two conditions to enable disease tracking and treatment monitoring. alzheimer’s disease; amyloid protein; exosomes; misfolded proteins; mitochondrial-derived vesicles; neuroinflammation; parkinson’s disease; quality control; tau protein; α-synuclein Neurology. Diseases of the nervous system Flora Guerra verfasserin aut Riccardo Calvani verfasserin aut Hélio José Coelho-Junior verfasserin aut Cecilia Bucci verfasserin aut Emanuele Marzetti verfasserin aut In Neural Regeneration Research Wolters Kluwer Medknow Publications, 2014 17(2022), 3, Seite 534-542 (DE-627)545785499 (DE-600)2388460-5 18767958 nnns volume:17 year:2022 number:3 pages:534-542 https://doi.org/10.4103/1673-5374.320972 kostenfrei https://doaj.org/article/c29c87aeb20f4aa4ba3e6ed4569af17d kostenfrei http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=3;spage=534;epage=542;aulast=Picca kostenfrei https://doaj.org/toc/1673-5374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2700 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 3 534-542
allfieldsGer	10.4103/1673-5374.320972 doi (DE-627)DOAJ002047195 (DE-599)DOAJc29c87aeb20f4aa4ba3e6ed4569af17d DE-627 ger DE-627 rakwb eng RC346-429 Anna Picca verfasserin aut Circulating extracellular vesicles: friends and foes in neurodegeneration 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological conditions. Via this route, several molecules (e.g., nucleic acids, proteins, metabolites) can be transferred to proximal and distant targets to convey specific information. Extracellular vesicle-associated cargo molecules have been proposed as markers of several disease conditions for their potential of tracking down the generating cell. Indeed, circulating extracellular vesicles may represent biomarkers of dysfunctional cellular quality control systems especially in conditions characterized by the accrual of intracellular misfolded proteins. Furthermore, the identification of extracellular vesicles as tools for the delivery of nucleic acids or other cargo molecules to diseased tissues makes these circulating shuttles possible targets for therapeutic development. The increasing interest in the study of extracellular vesicles as biomarkers resides mainly in the fact that the identification of peripheral levels of extracellular vesicle-associated proteins might reflect molecular events occurring in hardly accessible tissues, such as the brain, thereby serving as a “brain liquid biopsy”. The exploitation of extracellular vesicles for diagnostic and therapeutic purposed might offer unprecedented opportunities to develop personalized approaches. Here, we discuss the bright and dark sides of extracellular vesicles in the setting of two main neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). A special focus will be placed on the possibility of using extracellular vesicles as biomarkers for the two conditions to enable disease tracking and treatment monitoring. alzheimer’s disease; amyloid protein; exosomes; misfolded proteins; mitochondrial-derived vesicles; neuroinflammation; parkinson’s disease; quality control; tau protein; α-synuclein Neurology. Diseases of the nervous system Flora Guerra verfasserin aut Riccardo Calvani verfasserin aut Hélio José Coelho-Junior verfasserin aut Cecilia Bucci verfasserin aut Emanuele Marzetti verfasserin aut In Neural Regeneration Research Wolters Kluwer Medknow Publications, 2014 17(2022), 3, Seite 534-542 (DE-627)545785499 (DE-600)2388460-5 18767958 nnns volume:17 year:2022 number:3 pages:534-542 https://doi.org/10.4103/1673-5374.320972 kostenfrei https://doaj.org/article/c29c87aeb20f4aa4ba3e6ed4569af17d kostenfrei http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=3;spage=534;epage=542;aulast=Picca kostenfrei https://doaj.org/toc/1673-5374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2700 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 3 534-542
allfieldsSound	10.4103/1673-5374.320972 doi (DE-627)DOAJ002047195 (DE-599)DOAJc29c87aeb20f4aa4ba3e6ed4569af17d DE-627 ger DE-627 rakwb eng RC346-429 Anna Picca verfasserin aut Circulating extracellular vesicles: friends and foes in neurodegeneration 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological conditions. Via this route, several molecules (e.g., nucleic acids, proteins, metabolites) can be transferred to proximal and distant targets to convey specific information. Extracellular vesicle-associated cargo molecules have been proposed as markers of several disease conditions for their potential of tracking down the generating cell. Indeed, circulating extracellular vesicles may represent biomarkers of dysfunctional cellular quality control systems especially in conditions characterized by the accrual of intracellular misfolded proteins. Furthermore, the identification of extracellular vesicles as tools for the delivery of nucleic acids or other cargo molecules to diseased tissues makes these circulating shuttles possible targets for therapeutic development. The increasing interest in the study of extracellular vesicles as biomarkers resides mainly in the fact that the identification of peripheral levels of extracellular vesicle-associated proteins might reflect molecular events occurring in hardly accessible tissues, such as the brain, thereby serving as a “brain liquid biopsy”. The exploitation of extracellular vesicles for diagnostic and therapeutic purposed might offer unprecedented opportunities to develop personalized approaches. Here, we discuss the bright and dark sides of extracellular vesicles in the setting of two main neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). A special focus will be placed on the possibility of using extracellular vesicles as biomarkers for the two conditions to enable disease tracking and treatment monitoring. alzheimer’s disease; amyloid protein; exosomes; misfolded proteins; mitochondrial-derived vesicles; neuroinflammation; parkinson’s disease; quality control; tau protein; α-synuclein Neurology. Diseases of the nervous system Flora Guerra verfasserin aut Riccardo Calvani verfasserin aut Hélio José Coelho-Junior verfasserin aut Cecilia Bucci verfasserin aut Emanuele Marzetti verfasserin aut In Neural Regeneration Research Wolters Kluwer Medknow Publications, 2014 17(2022), 3, Seite 534-542 (DE-627)545785499 (DE-600)2388460-5 18767958 nnns volume:17 year:2022 number:3 pages:534-542 https://doi.org/10.4103/1673-5374.320972 kostenfrei https://doaj.org/article/c29c87aeb20f4aa4ba3e6ed4569af17d kostenfrei http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=3;spage=534;epage=542;aulast=Picca kostenfrei https://doaj.org/toc/1673-5374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2700 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 3 534-542
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callnumber-first	R - Medicine
author	Anna Picca
spellingShingle	Anna Picca misc RC346-429 misc alzheimer’s disease; amyloid protein; exosomes; misfolded proteins; mitochondrial-derived vesicles; neuroinflammation; parkinson’s disease; quality control; tau protein; α-synuclein misc Neurology. Diseases of the nervous system Circulating extracellular vesicles: friends and foes in neurodegeneration
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topic_title	RC346-429 Circulating extracellular vesicles: friends and foes in neurodegeneration alzheimer’s disease; amyloid protein; exosomes; misfolded proteins; mitochondrial-derived vesicles; neuroinflammation; parkinson’s disease; quality control; tau protein; α-synuclein
topic	misc RC346-429 misc alzheimer’s disease; amyloid protein; exosomes; misfolded proteins; mitochondrial-derived vesicles; neuroinflammation; parkinson’s disease; quality control; tau protein; α-synuclein misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RC346-429 misc alzheimer’s disease; amyloid protein; exosomes; misfolded proteins; mitochondrial-derived vesicles; neuroinflammation; parkinson’s disease; quality control; tau protein; α-synuclein misc Neurology. Diseases of the nervous system
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title	Circulating extracellular vesicles: friends and foes in neurodegeneration
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title_full	Circulating extracellular vesicles: friends and foes in neurodegeneration
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title_sort	circulating extracellular vesicles: friends and foes in neurodegeneration
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title_auth	Circulating extracellular vesicles: friends and foes in neurodegeneration
abstract	Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological conditions. Via this route, several molecules (e.g., nucleic acids, proteins, metabolites) can be transferred to proximal and distant targets to convey specific information. Extracellular vesicle-associated cargo molecules have been proposed as markers of several disease conditions for their potential of tracking down the generating cell. Indeed, circulating extracellular vesicles may represent biomarkers of dysfunctional cellular quality control systems especially in conditions characterized by the accrual of intracellular misfolded proteins. Furthermore, the identification of extracellular vesicles as tools for the delivery of nucleic acids or other cargo molecules to diseased tissues makes these circulating shuttles possible targets for therapeutic development. The increasing interest in the study of extracellular vesicles as biomarkers resides mainly in the fact that the identification of peripheral levels of extracellular vesicle-associated proteins might reflect molecular events occurring in hardly accessible tissues, such as the brain, thereby serving as a “brain liquid biopsy”. The exploitation of extracellular vesicles for diagnostic and therapeutic purposed might offer unprecedented opportunities to develop personalized approaches. Here, we discuss the bright and dark sides of extracellular vesicles in the setting of two main neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). A special focus will be placed on the possibility of using extracellular vesicles as biomarkers for the two conditions to enable disease tracking and treatment monitoring.
abstractGer	Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological conditions. Via this route, several molecules (e.g., nucleic acids, proteins, metabolites) can be transferred to proximal and distant targets to convey specific information. Extracellular vesicle-associated cargo molecules have been proposed as markers of several disease conditions for their potential of tracking down the generating cell. Indeed, circulating extracellular vesicles may represent biomarkers of dysfunctional cellular quality control systems especially in conditions characterized by the accrual of intracellular misfolded proteins. Furthermore, the identification of extracellular vesicles as tools for the delivery of nucleic acids or other cargo molecules to diseased tissues makes these circulating shuttles possible targets for therapeutic development. The increasing interest in the study of extracellular vesicles as biomarkers resides mainly in the fact that the identification of peripheral levels of extracellular vesicle-associated proteins might reflect molecular events occurring in hardly accessible tissues, such as the brain, thereby serving as a “brain liquid biopsy”. The exploitation of extracellular vesicles for diagnostic and therapeutic purposed might offer unprecedented opportunities to develop personalized approaches. Here, we discuss the bright and dark sides of extracellular vesicles in the setting of two main neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). A special focus will be placed on the possibility of using extracellular vesicles as biomarkers for the two conditions to enable disease tracking and treatment monitoring.
abstract_unstemmed	Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological conditions. Via this route, several molecules (e.g., nucleic acids, proteins, metabolites) can be transferred to proximal and distant targets to convey specific information. Extracellular vesicle-associated cargo molecules have been proposed as markers of several disease conditions for their potential of tracking down the generating cell. Indeed, circulating extracellular vesicles may represent biomarkers of dysfunctional cellular quality control systems especially in conditions characterized by the accrual of intracellular misfolded proteins. Furthermore, the identification of extracellular vesicles as tools for the delivery of nucleic acids or other cargo molecules to diseased tissues makes these circulating shuttles possible targets for therapeutic development. The increasing interest in the study of extracellular vesicles as biomarkers resides mainly in the fact that the identification of peripheral levels of extracellular vesicle-associated proteins might reflect molecular events occurring in hardly accessible tissues, such as the brain, thereby serving as a “brain liquid biopsy”. The exploitation of extracellular vesicles for diagnostic and therapeutic purposed might offer unprecedented opportunities to develop personalized approaches. Here, we discuss the bright and dark sides of extracellular vesicles in the setting of two main neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). A special focus will be placed on the possibility of using extracellular vesicles as biomarkers for the two conditions to enable disease tracking and treatment monitoring.
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title_short	Circulating extracellular vesicles: friends and foes in neurodegeneration
url	https://doi.org/10.4103/1673-5374.320972 https://doaj.org/article/c29c87aeb20f4aa4ba3e6ed4569af17d http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=3;spage=534;epage=542;aulast=Picca https://doaj.org/toc/1673-5374
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author2	Flora Guerra Riccardo Calvani Hélio José Coelho-Junior Cecilia Bucci Emanuele Marzetti
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up_date	2024-07-03T23:39:52.663Z
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