Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry)

Introduction Given an increasing use of dipeptidyl peptidase-4 (DPP-4) inhibitors to treat patients with type 2 diabetes mellitus in the real-world setting, we conducted a prospective observational study (Japan-based Clinical Research Network for Diabetes Registry: J-BRAND Registry) to elucidate the safety and efficacy profile of long-term usage of alogliptin.Research design and methods We registered 5969 patients from April 2012 through September 2014, who started receiving alogliptin (group A) or other classes of oral hypoglycemic agents (OHAs; group B), and were followed for 3 years at 239 sites nationwide. Safety was the primary outcome. Symptomatic hypoglycemia, pancreatitis, skin disorders of non-extrinsic origin, severe infections, and cancer were collected as major adverse events (AEs). Efficacy assessment was the secondary outcome and included changes in hemoglobin A1c (HbA1c), fasting blood glucose, fasting insulin and urinary albumin.Results Of the registered, 5150 (group A: 3395 and group B: 1755) and 5096 (3358 and 1738) were included for safety and efficacy analysis, respectively. Group A patients mostly (>90%) continued to use alogliptin. In group B, biguanides were the primary agents, while DPP-4 inhibitors were added in up to ~36% of patients. The overall incidence of AEs was similar between the two groups (42.7% vs 42.2%). Kaplan-Meier analysis revealed the incidence of cancer was significantly higher in group A than in group B (7.4% vs 4.8%, p=0.040), while no significant incidence difference was observed in the individual cancer. Multivariate Cox regression analysis revealed that the imbalanced patient distribution (more elderly patients in group A than in group B), but not alogliptin usage per se, contributed to cancer development. The incidence of other major AE categories was with no between-group difference. Between-group difference was not detected, either, in the incidence of microvascular and macrovascular complications. HbA1c and fasting glucose decreased significantly at the 0.5-year visit and nearly plateaued thereafter in both groups.Conclusions Alogliptin as a representative of DPP-4 inhibitors was safe and durably efficacious when used alone or with other OHAs for patients with type 2 diabetes in the real world setting. Ausführliche Beschreibung

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Autor*in:	Masakazu Kobayashi [verfasserIn] Hirohito Sone [verfasserIn] Haruhiko Osawa [verfasserIn] Daisuke Koya [verfasserIn] Takanori Miura [verfasserIn] Yoshihito Atsumi [verfasserIn] Udai Nakamura [verfasserIn] Eiichi Araki [verfasserIn] Hitoshi Shimano [verfasserIn] Yukio Tanizawa [verfasserIn] Jiro Nakamura [verfasserIn] Yuichiro Yamada [verfasserIn] Nobuya Inagaki [verfasserIn] Atsuko Abiko [verfasserIn] Hideki Katagiri [verfasserIn] Michio Hayashi [verfasserIn] Keiko Naruse [verfasserIn] Shimpei Fujimoto [verfasserIn] Masazumi Fujiwara [verfasserIn] Kenichi Shikata [verfasserIn] Yosuke Okada [verfasserIn] Tsutomu Yamazaki [verfasserIn] Sou Nagai [verfasserIn] Katsuyuki Yanagisawa [verfasserIn] Hiromichi Kijima [verfasserIn] Shinji Taneda [verfasserIn] Shigeyuki Saitoh [verfasserIn] Daisuke Ikeda [verfasserIn] Fuminori Hirano [verfasserIn] Haruhiko Yoshimura [verfasserIn] Mitsutaka Inoue [verfasserIn] Masahiko Katoh [verfasserIn] Osamu Nakagaki [verfasserIn] Chiho Yamamoto [verfasserIn] Akitsuki Morikawa [verfasserIn] Shin Furukawa [verfasserIn] Takeshi Koshiya [verfasserIn] Hajime Sugawara [verfasserIn] Takumi Uchida [verfasserIn] Noe Takakubo [verfasserIn] Yasushi Ishigaki [verfasserIn] Susumu Suzuki [verfasserIn] Takashi Shimotomai [verfasserIn] Naoki Tamasawa [verfasserIn] Jun Matsui [verfasserIn] Takashi Goto [verfasserIn] Toshihide Oizumi [verfasserIn] Shinji Susa [verfasserIn] Makoto Daimon [verfasserIn] Hiroshi Murakami [verfasserIn] Takashi Sugawara [verfasserIn] Hiroaki Akai [verfasserIn] Mari Nakamura [verfasserIn] Yoshiji Ogawa [verfasserIn] Takao Yokoshima [verfasserIn] Tsuyoshi Watanabe [verfasserIn] Michio Shimabukuro [verfasserIn] Kazuhisa Tsukamoto [verfasserIn] Motoei Kunimi [verfasserIn] Jo Satoh [verfasserIn] Atushi Okuyama [verfasserIn] Kazutaka Ogawa [verfasserIn] Hideyuki Eguchi [verfasserIn] Mamoru Kimura [verfasserIn] Hiroshi Kouno [verfasserIn] Yohei Horikawa [verfasserIn] Shin Ikejima [verfasserIn] Masaru Saitoh [verfasserIn] Naoyoshi Minami [verfasserIn] Akihiro Sekikawa [verfasserIn] Toyoyoshi Uchida [verfasserIn] Toshihide Kawai [verfasserIn] Nobuya Fujita [verfasserIn] Ken Tomotsune [verfasserIn] Shigeo Yamashita [verfasserIn] Motoji Naka [verfasserIn] Toru Hiyoshi [verfasserIn] Tomotaka Katoh [verfasserIn] Kumiko Hamano [verfasserIn] Kouichi Inukai [verfasserIn] Takuma Kondo [verfasserIn] Kazuhiro Tsumura [verfasserIn] Yoko Matsuzawa [verfasserIn] Masahiro Mimura [verfasserIn] Masahiko Kawasumi [verfasserIn] Izumi Takei [verfasserIn] Masafumi Matsuda [verfasserIn] Ichiro Tatsuno [verfasserIn] Nobuyuki Banba [verfasserIn] Akihiko Ando [verfasserIn] Masao Toyoda [verfasserIn] Daisuke Suzuki [verfasserIn] Takahiro Iijima [verfasserIn] Yasumichi Mori [verfasserIn] Yutaka Uehara [verfasserIn] Yoshihiko Satoh [verfasserIn] Kazuaki Yahata [verfasserIn] Yoshimasa Asoh [verfasserIn] Koichiro Kuwabara [verfasserIn] Souichi Takizawa [verfasserIn] Yasushi Tanaka [verfasserIn] Koutaroh Yokote [verfasserIn] Masako Tohgo [verfasserIn] Takanobu Itoi [verfasserIn] Shigeru Miyazaki [verfasserIn] Hiroshi Itoh [verfasserIn] Teruo Shiba [verfasserIn] Takahisa Hirose [verfasserIn] Mariko Higa [verfasserIn] Masanobu Yamada [verfasserIn] Osamu Ogawa [verfasserIn] Masatoshi Kuroki [verfasserIn] Shinobu Satoh [verfasserIn] Makoto Ujihara [verfasserIn] Kenjiroh Yamanaka [verfasserIn] Hajime Koyano [verfasserIn] Tadashi Yamakawa [verfasserIn] Kenichiroh Takahashi [verfasserIn] Kazuki Orime [verfasserIn] Tsutomu Hirano [verfasserIn] Jiroh Morimoto [verfasserIn] Takashi Itoh [verfasserIn] Yuzoh Mizuno [verfasserIn] Naoyuki Yamamoto [verfasserIn] Han Miyatake [verfasserIn] Mina Yamaguchi [verfasserIn] Kenji Yamane [verfasserIn] Masahiko Kure [verfasserIn] Satoko Kawabe [verfasserIn] Masahumi Kakei [verfasserIn] Masashi Yoshida [verfasserIn] Hiroyuki Itoh [verfasserIn] Nobuaki Minami [verfasserIn] Kazuki Kobayashi [verfasserIn] Yusuke Fujino [verfasserIn] Makoto Shibuya [verfasserIn] Midori Hosokawa [verfasserIn] Isao Nozaki [verfasserIn] Chigure Nawa [verfasserIn] Tamio Ieiri [verfasserIn] Takayuki Watanabe [verfasserIn] Yoshio Katoh [verfasserIn] Takuyuki Katabami [verfasserIn] Michiko Handa [verfasserIn] Issei Shimada [verfasserIn] Kenichi Ohya [verfasserIn] Yoshihiro Ogawa [verfasserIn] Takanobu Yoshimoto [verfasserIn] Jiroh Nakamura [verfasserIn] Naotsuka Okayama [verfasserIn] Kenro Imaeda [verfasserIn] Syuko Yoshioka [verfasserIn] Masako Murakami [verfasserIn] Takashi Murase [verfasserIn] Yoshihiko Yamada [verfasserIn] Yutaka Yano [verfasserIn] Hiromitsu Sasaki [verfasserIn] Yasuhiro Sumida [verfasserIn] Osamu Yonaha [verfasserIn] Hiroshi Sobajima [verfasserIn] Mitsuyasu Ito [verfasserIn] Atushi Suzuki [verfasserIn] Atsuko Ishikawa [verfasserIn] Takehiko Ichikawa [verfasserIn] Shogo Asano [verfasserIn] Shinobu Goto [verfasserIn] Sakuma Hiroya [verfasserIn] Hiroshi Murase [verfasserIn] Shozo Ogawa [verfasserIn] Hideki Okamoto [verfasserIn] Kotaro Nagai [verfasserIn] Koji Nagayama [verfasserIn] Masanori Yoshida [verfasserIn] Norio Takahashi [verfasserIn] Kazuhisa Takami [verfasserIn] Tsuneo Ono [verfasserIn] Takanobu Morihiro [verfasserIn] Daisuke Tanaka [verfasserIn] Noriko Takahara [verfasserIn] Satoshi Miyata [verfasserIn] Mamiko Tsugawa [verfasserIn] Koichiro Yasuda [verfasserIn] Seiji Muro [verfasserIn] Masanori Emoto [verfasserIn] Ikuo Mineo [verfasserIn] Ichiro Shiojima [verfasserIn] Takeshi Kurose [verfasserIn] Makoto Ohashi [verfasserIn] Yumiko Kawabata [verfasserIn] Mitsushige Nishikawa [verfasserIn] Emiko Nomura [verfasserIn] Yasuyuki Nishimura [verfasserIn] Yasuhiro Ono [verfasserIn] Yasuhisa Yamamoto [verfasserIn] Keigo Naka [verfasserIn] Taizo Yamamoto [verfasserIn] Rika Usuda [verfasserIn] Hiroshi Akahori [verfasserIn] Seika Kato [verfasserIn] Hiroyuki Konya [verfasserIn] Yutaka Umayahara [verfasserIn] Takashi Seta [verfasserIn] Hideki Taki [verfasserIn] Masashi Sekiya [verfasserIn] Shinichi Mogami [verfasserIn] Sumie Fujii [verfasserIn] Toshiyuki Hibuse [verfasserIn] Shingo Tsuji [verfasserIn] Hirofumi Sumi [verfasserIn] Yasuro Kumeda [verfasserIn] Akinori Kogure [verfasserIn] Kenji Furukawa [verfasserIn] Akira Kuroe [verfasserIn] Hideaki Sawaki [verfasserIn] Narihiro Hibiki [verfasserIn] Yoshihiro Kitagawa [verfasserIn] Yukihiro Bando [verfasserIn] Akira Ono [verfasserIn] Rikako Uenaka [verfasserIn] Seitaro Omoto [verfasserIn] Yuki Kita [verfasserIn] Eiko Ri [verfasserIn] Ryutaro Numaguchi [verfasserIn] Sachiko Kawashima [verfasserIn] Ichiro Kisimoto [verfasserIn] Kiminori Hosoda [verfasserIn] Yoshihiko Araki [verfasserIn] Tetsuroh Arimura [verfasserIn] Mitsuru Hashiramoto [verfasserIn] Koumei Takeda [verfasserIn] Akira Matsutani [verfasserIn] Yasushi Inoue [verfasserIn] Fumio Sawano [verfasserIn] Nozomu Kamei [verfasserIn] Yasuo Ito [verfasserIn] Miwa Morita [verfasserIn] Yoshiaki Oda [verfasserIn] Rui Kishimoto [verfasserIn] Katsuhiro Hatao [verfasserIn] Tomoatsu Mune [verfasserIn] Fumiko Kawasaki [verfasserIn] Hiroki Teragawa [verfasserIn] Ken Yaga [verfasserIn] Keita Ishii [verfasserIn] Kyouji Hirata [verfasserIn] Tatsuaki Nakatou [verfasserIn] Yutaka Nitta [verfasserIn] Naoki Fujita [verfasserIn] Masayasu Yoneda [verfasserIn] Masatoshi Tsuru [verfasserIn] Shinichirou Ando [verfasserIn] Toshiaki Kakiba [verfasserIn] Michihiro Toyoshige [verfasserIn] Tsuguka Shiwa [verfasserIn] Hiroaki Miyaoka [verfasserIn] Yasumi Shintani [verfasserIn] Takenori Sakai [verfasserIn] Tetsuji Niiya [verfasserIn] Shinpei Fujimoto [verfasserIn] Hisaka Minami [verfasserIn] Yoshihiko Noma [verfasserIn] Masaaki Tamaru [verfasserIn] Yoshitaka Sayou [verfasserIn] Tomoyo Oyama [verfasserIn] Masamoto Torisu [verfasserIn] Yuichi Fujinaka [verfasserIn] Yoshitaka Kumon [verfasserIn] Shozo Miyauchi [verfasserIn] Morikazu Onji [verfasserIn] Toru Nakamura [verfasserIn] Yousuke Okada [verfasserIn] Toshihiko Yanase [verfasserIn] Kenro Nishida [verfasserIn] Syuji Nakamura [verfasserIn] Kunihisa Kobayashi [verfasserIn] Nobuhiko Wada [verfasserIn] Moritake Higa [verfasserIn] Koji Matsushita [verfasserIn] Yoshihiko Nishio [verfasserIn] Ryoji Fujimoto [verfasserIn] Yasuyuki Kihara [verfasserIn] Shinichiro Mine [verfasserIn] Tadashi Arao [verfasserIn] Hiromi Tasaki [verfasserIn] Yasuto Matsuo [verfasserIn] Hirofumi Matsuda [verfasserIn] Kohei Uriu [verfasserIn] Kazuko Kanda [verfasserIn] Kazuo Ibaraki [verfasserIn] Yoshio Kaku [verfasserIn] Yasuhiro Takaki [verfasserIn] Iwaho Hazekawa [verfasserIn] Kenji Ebihara [verfasserIn] Eiichiro Watanabe [verfasserIn] Iku Sakurada [verfasserIn] Kazuhisa Muraishi [verfasserIn] Tamami Oshige [verfasserIn] Junichi Yasuda [verfasserIn] Toyoshi Iguchi [verfasserIn] Noriyuki Sonoda [verfasserIn] Masahiro Adachi [verfasserIn] Isao Ichino [verfasserIn] Yuko Horiuchi [verfasserIn] Souichi Uekihara [verfasserIn] Shingo Morimitsu [verfasserIn] Mitsuhiro Nakazawa [verfasserIn] Tadashi Seguchi [verfasserIn] Kengo Kaneko [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: BMJ Open Diabetes Research & Care - BMJ Publishing Group, 2016, 9(2021), 1
Übergeordnetes Werk:	volume:9 ; year:2021 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1136/bmjdrc-2020-001787

Katalog-ID:	DOAJ002062054

Internformat


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024	7		\|a 10.1136/bmjdrc-2020-001787 \|2 doi
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041			\|a eng
050		0	\|a RC648-665
100	0		\|a Masakazu Kobayashi \|e verfasserin \|4 aut
245	1	0	\|a Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry)
264		1	\|c 2021
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Introduction Given an increasing use of dipeptidyl peptidase-4 (DPP-4) inhibitors to treat patients with type 2 diabetes mellitus in the real-world setting, we conducted a prospective observational study (Japan-based Clinical Research Network for Diabetes Registry: J-BRAND Registry) to elucidate the safety and efficacy profile of long-term usage of alogliptin.Research design and methods We registered 5969 patients from April 2012 through September 2014, who started receiving alogliptin (group A) or other classes of oral hypoglycemic agents (OHAs; group B), and were followed for 3 years at 239 sites nationwide. Safety was the primary outcome. Symptomatic hypoglycemia, pancreatitis, skin disorders of non-extrinsic origin, severe infections, and cancer were collected as major adverse events (AEs). Efficacy assessment was the secondary outcome and included changes in hemoglobin A1c (HbA1c), fasting blood glucose, fasting insulin and urinary albumin.Results Of the registered, 5150 (group A: 3395 and group B: 1755) and 5096 (3358 and 1738) were included for safety and efficacy analysis, respectively. Group A patients mostly (>90%) continued to use alogliptin. In group B, biguanides were the primary agents, while DPP-4 inhibitors were added in up to ~36% of patients. The overall incidence of AEs was similar between the two groups (42.7% vs 42.2%). Kaplan-Meier analysis revealed the incidence of cancer was significantly higher in group A than in group B (7.4% vs 4.8%, p=0.040), while no significant incidence difference was observed in the individual cancer. Multivariate Cox regression analysis revealed that the imbalanced patient distribution (more elderly patients in group A than in group B), but not alogliptin usage per se, contributed to cancer development. The incidence of other major AE categories was with no between-group difference. Between-group difference was not detected, either, in the incidence of microvascular and macrovascular complications. HbA1c and fasting glucose decreased significantly at the 0.5-year visit and nearly plateaued thereafter in both groups.Conclusions Alogliptin as a representative of DPP-4 inhibitors was safe and durably efficacious when used alone or with other OHAs for patients with type 2 diabetes in the real world setting.
653		0	\|a Diseases of the endocrine glands. Clinical endocrinology
700	0		\|a Hirohito Sone \|e verfasserin \|4 aut
700	0		\|a Haruhiko Osawa \|e verfasserin \|4 aut
700	0		\|a Daisuke Koya \|e verfasserin \|4 aut
700	0		\|a Takanori Miura \|e verfasserin \|4 aut
700	0		\|a Yoshihito Atsumi \|e verfasserin \|4 aut
700	0		\|a Udai Nakamura \|e verfasserin \|4 aut
700	0		\|a Eiichi Araki \|e verfasserin \|4 aut
700	0		\|a Hitoshi Shimano \|e verfasserin \|4 aut
700	0		\|a Yukio Tanizawa \|e verfasserin \|4 aut
700	0		\|a Jiro Nakamura \|e verfasserin \|4 aut
700	0		\|a Yuichiro Yamada \|e verfasserin \|4 aut
700	0		\|a Nobuya Inagaki \|e verfasserin \|4 aut
700	0		\|a Atsuko Abiko \|e verfasserin \|4 aut
700	0		\|a Hideki Katagiri \|e verfasserin \|4 aut
700	0		\|a Michio Hayashi \|e verfasserin \|4 aut
700	0		\|a Keiko Naruse \|e verfasserin \|4 aut
700	0		\|a Shimpei Fujimoto \|e verfasserin \|4 aut
700	0		\|a Masazumi Fujiwara \|e verfasserin \|4 aut
700	0		\|a Kenichi Shikata \|e verfasserin \|4 aut
700	0		\|a Yosuke Okada \|e verfasserin \|4 aut
700	0		\|a Tsutomu Yamazaki \|e verfasserin \|4 aut
700	0		\|a Sou Nagai \|e verfasserin \|4 aut
700	0		\|a Katsuyuki Yanagisawa \|e verfasserin \|4 aut
700	0		\|a Hiromichi Kijima \|e verfasserin \|4 aut
700	0		\|a Shinji Taneda \|e verfasserin \|4 aut
700	0		\|a Shigeyuki Saitoh \|e verfasserin \|4 aut
700	0		\|a Daisuke Ikeda \|e verfasserin \|4 aut
700	0		\|a Fuminori Hirano \|e verfasserin \|4 aut
700	0		\|a Haruhiko Yoshimura \|e verfasserin \|4 aut
700	0		\|a Mitsutaka Inoue \|e verfasserin \|4 aut
700	0		\|a Masahiko Katoh \|e verfasserin \|4 aut
700	0		\|a Osamu Nakagaki \|e verfasserin \|4 aut
700	0		\|a Chiho Yamamoto \|e verfasserin \|4 aut
700	0		\|a Akitsuki Morikawa \|e verfasserin \|4 aut
700	0		\|a Shin Furukawa \|e verfasserin \|4 aut
700	0		\|a Takeshi Koshiya \|e verfasserin \|4 aut
700	0		\|a Hajime Sugawara \|e verfasserin \|4 aut
700	0		\|a Takumi Uchida \|e verfasserin \|4 aut
700	0		\|a Noe Takakubo \|e verfasserin \|4 aut
700	0		\|a Yasushi Ishigaki \|e verfasserin \|4 aut
700	0		\|a Susumu Suzuki \|e verfasserin \|4 aut
700	0		\|a Takashi Shimotomai \|e verfasserin \|4 aut
700	0		\|a Naoki Tamasawa \|e verfasserin \|4 aut
700	0		\|a Jun Matsui \|e verfasserin \|4 aut
700	0		\|a Takashi Goto \|e verfasserin \|4 aut
700	0		\|a Toshihide Oizumi \|e verfasserin \|4 aut
700	0		\|a Shinji Susa \|e verfasserin \|4 aut
700	0		\|a Makoto Daimon \|e verfasserin \|4 aut
700	0		\|a Hiroshi Murakami \|e verfasserin \|4 aut
700	0		\|a Takashi Sugawara \|e verfasserin \|4 aut
700	0		\|a Hiroaki Akai \|e verfasserin \|4 aut
700	0		\|a Mari Nakamura \|e verfasserin \|4 aut
700	0		\|a Yoshiji Ogawa \|e verfasserin \|4 aut
700	0		\|a Takao Yokoshima \|e verfasserin \|4 aut
700	0		\|a Tsuyoshi Watanabe \|e verfasserin \|4 aut
700	0		\|a Michio Shimabukuro \|e verfasserin \|4 aut
700	0		\|a Kazuhisa Tsukamoto \|e verfasserin \|4 aut
700	0		\|a Motoei Kunimi \|e verfasserin \|4 aut
700	0		\|a Jo Satoh \|e verfasserin \|4 aut
700	0		\|a Atushi Okuyama \|e verfasserin \|4 aut
700	0		\|a Kazutaka Ogawa \|e verfasserin \|4 aut
700	0		\|a Hideyuki Eguchi \|e verfasserin \|4 aut
700	0		\|a Mamoru Kimura \|e verfasserin \|4 aut
700	0		\|a Hiroshi Kouno \|e verfasserin \|4 aut
700	0		\|a Yohei Horikawa \|e verfasserin \|4 aut
700	0		\|a Shin Ikejima \|e verfasserin \|4 aut
700	0		\|a Masaru Saitoh \|e verfasserin \|4 aut
700	0		\|a Naoyoshi Minami \|e verfasserin \|4 aut
700	0		\|a Akihiro Sekikawa \|e verfasserin \|4 aut
700	0		\|a Toyoyoshi Uchida \|e verfasserin \|4 aut
700	0		\|a Toshihide Kawai \|e verfasserin \|4 aut
700	0		\|a Nobuya Fujita \|e verfasserin \|4 aut
700	0		\|a Ken Tomotsune \|e verfasserin \|4 aut
700	0		\|a Shigeo Yamashita \|e verfasserin \|4 aut
700	0		\|a Motoji Naka \|e verfasserin \|4 aut
700	0		\|a Toru Hiyoshi \|e verfasserin \|4 aut
700	0		\|a Tomotaka Katoh \|e verfasserin \|4 aut
700	0		\|a Kumiko Hamano \|e verfasserin \|4 aut
700	0		\|a Kouichi Inukai \|e verfasserin \|4 aut
700	0		\|a Takuma Kondo \|e verfasserin \|4 aut
700	0		\|a Kazuhiro Tsumura \|e verfasserin \|4 aut
700	0		\|a Yoko Matsuzawa \|e verfasserin \|4 aut
700	0		\|a Masahiro Mimura \|e verfasserin \|4 aut
700	0		\|a Masahiko Kawasumi \|e verfasserin \|4 aut
700	0		\|a Izumi Takei \|e verfasserin \|4 aut
700	0		\|a Masafumi Matsuda \|e verfasserin \|4 aut
700	0		\|a Ichiro Tatsuno \|e verfasserin \|4 aut
700	0		\|a Nobuyuki Banba \|e verfasserin \|4 aut
700	0		\|a Akihiko Ando \|e verfasserin \|4 aut
700	0		\|a Masao Toyoda \|e verfasserin \|4 aut
700	0		\|a Daisuke Suzuki \|e verfasserin \|4 aut
700	0		\|a Takahiro Iijima \|e verfasserin \|4 aut
700	0		\|a Yasumichi Mori \|e verfasserin \|4 aut
700	0		\|a Yutaka Uehara \|e verfasserin \|4 aut
700	0		\|a Yoshihiko Satoh \|e verfasserin \|4 aut
700	0		\|a Kazuaki Yahata \|e verfasserin \|4 aut
700	0		\|a Yoshimasa Asoh \|e verfasserin \|4 aut
700	0		\|a Koichiro Kuwabara \|e verfasserin \|4 aut
700	0		\|a Souichi Takizawa \|e verfasserin \|4 aut
700	0		\|a Yasushi Tanaka \|e verfasserin \|4 aut
700	0		\|a Koutaroh Yokote \|e verfasserin \|4 aut
700	0		\|a Masako Tohgo \|e verfasserin \|4 aut
700	0		\|a Takanobu Itoi \|e verfasserin \|4 aut
700	0		\|a Shigeru Miyazaki \|e verfasserin \|4 aut
700	0		\|a Hiroshi Itoh \|e verfasserin \|4 aut
700	0		\|a Teruo Shiba \|e verfasserin \|4 aut
700	0		\|a Takahisa Hirose \|e verfasserin \|4 aut
700	0		\|a Mariko Higa \|e verfasserin \|4 aut
700	0		\|a Masanobu Yamada \|e verfasserin \|4 aut
700	0		\|a Osamu Ogawa \|e verfasserin \|4 aut
700	0		\|a Masatoshi Kuroki \|e verfasserin \|4 aut
700	0		\|a Shinobu Satoh \|e verfasserin \|4 aut
700	0		\|a Makoto Ujihara \|e verfasserin \|4 aut
700	0		\|a Kenjiroh Yamanaka \|e verfasserin \|4 aut
700	0		\|a Hajime Koyano \|e verfasserin \|4 aut
700	0		\|a Tadashi Yamakawa \|e verfasserin \|4 aut
700	0		\|a Kenichiroh Takahashi \|e verfasserin \|4 aut
700	0		\|a Kazuki Orime \|e verfasserin \|4 aut
700	0		\|a Tsutomu Hirano \|e verfasserin \|4 aut
700	0		\|a Jiroh Morimoto \|e verfasserin \|4 aut
700	0		\|a Takashi Itoh \|e verfasserin \|4 aut
700	0		\|a Yuzoh Mizuno \|e verfasserin \|4 aut
700	0		\|a Naoyuki Yamamoto \|e verfasserin \|4 aut
700	0		\|a Han Miyatake \|e verfasserin \|4 aut
700	0		\|a Mina Yamaguchi \|e verfasserin \|4 aut
700	0		\|a Kenji Yamane \|e verfasserin \|4 aut
700	0		\|a Masahiko Kure \|e verfasserin \|4 aut
700	0		\|a Satoko Kawabe \|e verfasserin \|4 aut
700	0		\|a Masahumi Kakei \|e verfasserin \|4 aut
700	0		\|a Masashi Yoshida \|e verfasserin \|4 aut
700	0		\|a Hiroyuki Itoh \|e verfasserin \|4 aut
700	0		\|a Nobuaki Minami \|e verfasserin \|4 aut
700	0		\|a Kazuki Kobayashi \|e verfasserin \|4 aut
700	0		\|a Yusuke Fujino \|e verfasserin \|4 aut
700	0		\|a Makoto Shibuya \|e verfasserin \|4 aut
700	0		\|a Midori Hosokawa \|e verfasserin \|4 aut
700	0		\|a Isao Nozaki \|e verfasserin \|4 aut
700	0		\|a Chigure Nawa \|e verfasserin \|4 aut
700	0		\|a Tamio Ieiri \|e verfasserin \|4 aut
700	0		\|a Takayuki Watanabe \|e verfasserin \|4 aut
700	0		\|a Yoshio Katoh \|e verfasserin \|4 aut
700	0		\|a Takuyuki Katabami \|e verfasserin \|4 aut
700	0		\|a Michiko Handa \|e verfasserin \|4 aut
700	0		\|a Issei Shimada \|e verfasserin \|4 aut
700	0		\|a Kenichi Ohya \|e verfasserin \|4 aut
700	0		\|a Yoshihiro Ogawa \|e verfasserin \|4 aut
700	0		\|a Takanobu Yoshimoto \|e verfasserin \|4 aut
700	0		\|a Jiroh Nakamura \|e verfasserin \|4 aut
700	0		\|a Naotsuka Okayama \|e verfasserin \|4 aut
700	0		\|a Kenro Imaeda \|e verfasserin \|4 aut
700	0		\|a Syuko Yoshioka \|e verfasserin \|4 aut
700	0		\|a Masako Murakami \|e verfasserin \|4 aut
700	0		\|a Takashi Murase \|e verfasserin \|4 aut
700	0		\|a Yoshihiko Yamada \|e verfasserin \|4 aut
700	0		\|a Yutaka Yano \|e verfasserin \|4 aut
700	0		\|a Hiromitsu Sasaki \|e verfasserin \|4 aut
700	0		\|a Yasuhiro Sumida \|e verfasserin \|4 aut
700	0		\|a Osamu Yonaha \|e verfasserin \|4 aut
700	0		\|a Hiroshi Sobajima \|e verfasserin \|4 aut
700	0		\|a Mitsuyasu Ito \|e verfasserin \|4 aut
700	0		\|a Atushi Suzuki \|e verfasserin \|4 aut
700	0		\|a Atsuko Ishikawa \|e verfasserin \|4 aut
700	0		\|a Takehiko Ichikawa \|e verfasserin \|4 aut
700	0		\|a Shogo Asano \|e verfasserin \|4 aut
700	0		\|a Shinobu Goto \|e verfasserin \|4 aut
700	0		\|a Sakuma Hiroya \|e verfasserin \|4 aut
700	0		\|a Hiroshi Murase \|e verfasserin \|4 aut
700	0		\|a Shozo Ogawa \|e verfasserin \|4 aut
700	0		\|a Hideki Okamoto \|e verfasserin \|4 aut
700	0		\|a Kotaro Nagai \|e verfasserin \|4 aut
700	0		\|a Koji Nagayama \|e verfasserin \|4 aut
700	0		\|a Masanori Yoshida \|e verfasserin \|4 aut
700	0		\|a Norio Takahashi \|e verfasserin \|4 aut
700	0		\|a Kazuhisa Takami \|e verfasserin \|4 aut
700	0		\|a Tsuneo Ono \|e verfasserin \|4 aut
700	0		\|a Takanobu Morihiro \|e verfasserin \|4 aut
700	0		\|a Daisuke Tanaka \|e verfasserin \|4 aut
700	0		\|a Noriko Takahara \|e verfasserin \|4 aut
700	0		\|a Satoshi Miyata \|e verfasserin \|4 aut
700	0		\|a Mamiko Tsugawa \|e verfasserin \|4 aut
700	0		\|a Koichiro Yasuda \|e verfasserin \|4 aut
700	0		\|a Seiji Muro \|e verfasserin \|4 aut
700	0		\|a Masanori Emoto \|e verfasserin \|4 aut
700	0		\|a Ikuo Mineo \|e verfasserin \|4 aut
700	0		\|a Ichiro Shiojima \|e verfasserin \|4 aut
700	0		\|a Takeshi Kurose \|e verfasserin \|4 aut
700	0		\|a Makoto Ohashi \|e verfasserin \|4 aut
700	0		\|a Yumiko Kawabata \|e verfasserin \|4 aut
700	0		\|a Mitsushige Nishikawa \|e verfasserin \|4 aut
700	0		\|a Emiko Nomura \|e verfasserin \|4 aut
700	0		\|a Yasuyuki Nishimura \|e verfasserin \|4 aut
700	0		\|a Yasuhiro Ono \|e verfasserin \|4 aut
700	0		\|a Yasuhisa Yamamoto \|e verfasserin \|4 aut
700	0		\|a Keigo Naka \|e verfasserin \|4 aut
700	0		\|a Taizo Yamamoto \|e verfasserin \|4 aut
700	0		\|a Rika Usuda \|e verfasserin \|4 aut
700	0		\|a Hiroshi Akahori \|e verfasserin \|4 aut
700	0		\|a Seika Kato \|e verfasserin \|4 aut
700	0		\|a Hiroyuki Konya \|e verfasserin \|4 aut
700	0		\|a Yutaka Umayahara \|e verfasserin \|4 aut
700	0		\|a Takashi Seta \|e verfasserin \|4 aut
700	0		\|a Hideki Taki \|e verfasserin \|4 aut
700	0		\|a Masashi Sekiya \|e verfasserin \|4 aut
700	0		\|a Shinichi Mogami \|e verfasserin \|4 aut
700	0		\|a Sumie Fujii \|e verfasserin \|4 aut
700	0		\|a Toshiyuki Hibuse \|e verfasserin \|4 aut
700	0		\|a Shingo Tsuji \|e verfasserin \|4 aut
700	0		\|a Hirofumi Sumi \|e verfasserin \|4 aut
700	0		\|a Yasuro Kumeda \|e verfasserin \|4 aut
700	0		\|a Akinori Kogure \|e verfasserin \|4 aut
700	0		\|a Kenji Furukawa \|e verfasserin \|4 aut
700	0		\|a Akira Kuroe \|e verfasserin \|4 aut
700	0		\|a Hideaki Sawaki \|e verfasserin \|4 aut
700	0		\|a Narihiro Hibiki \|e verfasserin \|4 aut
700	0		\|a Yoshihiro Kitagawa \|e verfasserin \|4 aut
700	0		\|a Yukihiro Bando \|e verfasserin \|4 aut
700	0		\|a Akira Ono \|e verfasserin \|4 aut
700	0		\|a Rikako Uenaka \|e verfasserin \|4 aut
700	0		\|a Seitaro Omoto \|e verfasserin \|4 aut
700	0		\|a Yuki Kita \|e verfasserin \|4 aut
700	0		\|a Eiko Ri \|e verfasserin \|4 aut
700	0		\|a Ryutaro Numaguchi \|e verfasserin \|4 aut
700	0		\|a Sachiko Kawashima \|e verfasserin \|4 aut
700	0		\|a Ichiro Kisimoto \|e verfasserin \|4 aut
700	0		\|a Kiminori Hosoda \|e verfasserin \|4 aut
700	0		\|a Yoshihiko Araki \|e verfasserin \|4 aut
700	0		\|a Tetsuroh Arimura \|e verfasserin \|4 aut
700	0		\|a Mitsuru Hashiramoto \|e verfasserin \|4 aut
700	0		\|a Koumei Takeda \|e verfasserin \|4 aut
700	0		\|a Akira Matsutani \|e verfasserin \|4 aut
700	0		\|a Yasushi Inoue \|e verfasserin \|4 aut
700	0		\|a Fumio Sawano \|e verfasserin \|4 aut
700	0		\|a Nozomu Kamei \|e verfasserin \|4 aut
700	0		\|a Yasuo Ito \|e verfasserin \|4 aut
700	0		\|a Miwa Morita \|e verfasserin \|4 aut
700	0		\|a Yoshiaki Oda \|e verfasserin \|4 aut
700	0		\|a Rui Kishimoto \|e verfasserin \|4 aut
700	0		\|a Katsuhiro Hatao \|e verfasserin \|4 aut
700	0		\|a Tomoatsu Mune \|e verfasserin \|4 aut
700	0		\|a Fumiko Kawasaki \|e verfasserin \|4 aut
700	0		\|a Hiroki Teragawa \|e verfasserin \|4 aut
700	0		\|a Ken Yaga \|e verfasserin \|4 aut
700	0		\|a Keita Ishii \|e verfasserin \|4 aut
700	0		\|a Kyouji Hirata \|e verfasserin \|4 aut
700	0		\|a Tatsuaki Nakatou \|e verfasserin \|4 aut
700	0		\|a Yutaka Nitta \|e verfasserin \|4 aut
700	0		\|a Naoki Fujita \|e verfasserin \|4 aut
700	0		\|a Masayasu Yoneda \|e verfasserin \|4 aut
700	0		\|a Masatoshi Tsuru \|e verfasserin \|4 aut
700	0		\|a Shinichirou Ando \|e verfasserin \|4 aut
700	0		\|a Toshiaki Kakiba \|e verfasserin \|4 aut
700	0		\|a Michihiro Toyoshige \|e verfasserin \|4 aut
700	0		\|a Tsuguka Shiwa \|e verfasserin \|4 aut
700	0		\|a Hiroaki Miyaoka \|e verfasserin \|4 aut
700	0		\|a Yasumi Shintani \|e verfasserin \|4 aut
700	0		\|a Takenori Sakai \|e verfasserin \|4 aut
700	0		\|a Tetsuji Niiya \|e verfasserin \|4 aut
700	0		\|a Shinpei Fujimoto \|e verfasserin \|4 aut
700	0		\|a Hisaka Minami \|e verfasserin \|4 aut
700	0		\|a Yoshihiko Noma \|e verfasserin \|4 aut
700	0		\|a Masaaki Tamaru \|e verfasserin \|4 aut
700	0		\|a Yoshitaka Sayou \|e verfasserin \|4 aut
700	0		\|a Tomoyo Oyama \|e verfasserin \|4 aut
700	0		\|a Masamoto Torisu \|e verfasserin \|4 aut
700	0		\|a Yuichi Fujinaka \|e verfasserin \|4 aut
700	0		\|a Yoshitaka Kumon \|e verfasserin \|4 aut
700	0		\|a Shozo Miyauchi \|e verfasserin \|4 aut
700	0		\|a Morikazu Onji \|e verfasserin \|4 aut
700	0		\|a Toru Nakamura \|e verfasserin \|4 aut
700	0		\|a Yousuke Okada \|e verfasserin \|4 aut
700	0		\|a Toshihiko Yanase \|e verfasserin \|4 aut
700	0		\|a Kenro Nishida \|e verfasserin \|4 aut
700	0		\|a Syuji Nakamura \|e verfasserin \|4 aut
700	0		\|a Kunihisa Kobayashi \|e verfasserin \|4 aut
700	0		\|a Nobuhiko Wada \|e verfasserin \|4 aut
700	0		\|a Moritake Higa \|e verfasserin \|4 aut
700	0		\|a Koji Matsushita \|e verfasserin \|4 aut
700	0		\|a Yoshihiko Nishio \|e verfasserin \|4 aut
700	0		\|a Ryoji Fujimoto \|e verfasserin \|4 aut
700	0		\|a Yasuyuki Kihara \|e verfasserin \|4 aut
700	0		\|a Shinichiro Mine \|e verfasserin \|4 aut
700	0		\|a Tadashi Arao \|e verfasserin \|4 aut
700	0		\|a Hiromi Tasaki \|e verfasserin \|4 aut
700	0		\|a Yasuto Matsuo \|e verfasserin \|4 aut
700	0		\|a Hirofumi Matsuda \|e verfasserin \|4 aut
700	0		\|a Kohei Uriu \|e verfasserin \|4 aut
700	0		\|a Kazuko Kanda \|e verfasserin \|4 aut
700	0		\|a Kazuo Ibaraki \|e verfasserin \|4 aut
700	0		\|a Yoshio Kaku \|e verfasserin \|4 aut
700	0		\|a Yasuhiro Takaki \|e verfasserin \|4 aut
700	0		\|a Iwaho Hazekawa \|e verfasserin \|4 aut
700	0		\|a Kenji Ebihara \|e verfasserin \|4 aut
700	0		\|a Eiichiro Watanabe \|e verfasserin \|4 aut
700	0		\|a Iku Sakurada \|e verfasserin \|4 aut
700	0		\|a Kazuhisa Muraishi \|e verfasserin \|4 aut
700	0		\|a Tamami Oshige \|e verfasserin \|4 aut
700	0		\|a Junichi Yasuda \|e verfasserin \|4 aut
700	0		\|a Toyoshi Iguchi \|e verfasserin \|4 aut
700	0		\|a Noriyuki Sonoda \|e verfasserin \|4 aut
700	0		\|a Masahiro Adachi \|e verfasserin \|4 aut
700	0		\|a Isao Ichino \|e verfasserin \|4 aut
700	0		\|a Yuko Horiuchi \|e verfasserin \|4 aut
700	0		\|a Souichi Uekihara \|e verfasserin \|4 aut
700	0		\|a Shingo Morimitsu \|e verfasserin \|4 aut
700	0		\|a Mitsuhiro Nakazawa \|e verfasserin \|4 aut
700	0		\|a Tadashi Seguchi \|e verfasserin \|4 aut
700	0		\|a Kengo Kaneko \|e verfasserin \|4 aut
773	0	8	\|i In \|t BMJ Open Diabetes Research & Care \|d BMJ Publishing Group, 2016 \|g 9(2021), 1 \|w (DE-627)768094542 \|w (DE-600)2732918-5 \|x 20524897 \|7 nnns
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856	4	0	\|u https://drc.bmj.com/content/9/1/e001787.full \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/2052-4897 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
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912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 9 \|j 2021 \|e 1

Indexfelder

author_variant	m k mk h s hs h o ho d k dk t m tm y a ya u n un e a ea h s hs y t yt j n jn y y yy n i ni a a aa h k hk m h mh k n kn s f sf m f mf k s ks y o yo t y ty s n sn k y ky h k hk s t st s s ss d i di f h fh h y hy m i mi m k mk o n on c y cy a m am s f sf t k tk h s hs t u tu n t nt y i yi s s ss t s ts n t nt j m jm t g tg t o to s s ss m d md h m hm t s ts h a ha m n mn y o yo t y ty t w tw m s ms k t kt m k mk j s js a o ao k o ko h e he m k mk h k hk y h yh s i si m s ms n m nm a s as t u tu t k tk n f nf k t kt s y sy m n mn t h th t k tk k h kh k i ki t k tk k t kt y m ym m m mm m k mk i t it m m mm i t it n b nb a a aa m t mt d s ds t i ti y m ym y u yu y s ys k y ky y a ya k k kk s t st y t yt k y ky m t mt t i ti s m sm h i hi t s ts t h th m h mh m y my o o oo m k mk s s ss m u mu k y ky h k hk t y ty k t kt k o ko t h th j m jm t i ti y m ym n y ny h m hm m y my k y ky m k mk s k sk m k mk m y my h i hi n m nm k k kk y f yf m s ms m h mh i n in c n cn t i ti t w tw y k yk t k tk m h mh i s is k o ko y o yo t y ty j n jn n o no k i ki s y sy m m mm t m tm y y yy y y yy h s hs y s ys o y oy h s hs m i mi a s as a i ai t i ti s a sa s g sg s h sh h m hm s o so h o ho k n kn k n kn m y my n t nt k t kt t o to t m tm d t dt n t nt s m sm m t mt k y ky s m sm m e me i m im i s is t k tk m o mo y k yk m n mn e n en y n yn y o yo y y yy k n kn t y ty r u ru h a ha s k sk h k hk y u yu t s ts h t ht m s ms s m sm s f sf t h th s t st h s hs y k yk a k ak k f kf a k ak h s hs n h nh y k yk y b yb a o ao r u ru s o so y k yk e r er r n rn s k sk i k ik k h kh y a ya t a ta m h mh k t kt a m am y i yi f s fs n k nk y i yi m m mm y o yo r k rk k h kh t m tm f k fk h t ht k y ky k i ki k h kh t n tn y n yn n f nf m y my m t mt s a sa t k tk m t mt t s ts h m hm y s ys t s ts t n tn s f sf h m hm y n yn m t mt y s ys t o to m t mt y f yf y k yk s m sm m o mo t n tn y o yo t y ty k n kn s n sn k k kk n w nw m h mh k m km y n yn r f rf y k yk s m sm t a ta h t ht y m ym h m hm k u ku k k kk k i ki y k yk y t yt i h ih k e ke e w ew i s is k m km t o to j y jy t i ti n s ns m a ma i i ii y h yh s u su s m sm m n mn t s ts k k kk
matchkey_str	article:20524897:2021----::ogemaeynefccoaolpiap4niioiptetwttp2ibts3errsetvcnrl
hierarchy_sort_str	2021
callnumber-subject-code	RC
publishDate	2021
allfields	10.1136/bmjdrc-2020-001787 doi (DE-627)DOAJ002062054 (DE-599)DOAJ9dc90dc2c997472e81cb2c1c6cd779d5 DE-627 ger DE-627 rakwb eng RC648-665 Masakazu Kobayashi verfasserin aut Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction Given an increasing use of dipeptidyl peptidase-4 (DPP-4) inhibitors to treat patients with type 2 diabetes mellitus in the real-world setting, we conducted a prospective observational study (Japan-based Clinical Research Network for Diabetes Registry: J-BRAND Registry) to elucidate the safety and efficacy profile of long-term usage of alogliptin.Research design and methods We registered 5969 patients from April 2012 through September 2014, who started receiving alogliptin (group A) or other classes of oral hypoglycemic agents (OHAs; group B), and were followed for 3 years at 239 sites nationwide. Safety was the primary outcome. Symptomatic hypoglycemia, pancreatitis, skin disorders of non-extrinsic origin, severe infections, and cancer were collected as major adverse events (AEs). Efficacy assessment was the secondary outcome and included changes in hemoglobin A1c (HbA1c), fasting blood glucose, fasting insulin and urinary albumin.Results Of the registered, 5150 (group A: 3395 and group B: 1755) and 5096 (3358 and 1738) were included for safety and efficacy analysis, respectively. Group A patients mostly (>90%) continued to use alogliptin. In group B, biguanides were the primary agents, while DPP-4 inhibitors were added in up to ~36% of patients. The overall incidence of AEs was similar between the two groups (42.7% vs 42.2%). Kaplan-Meier analysis revealed the incidence of cancer was significantly higher in group A than in group B (7.4% vs 4.8%, p=0.040), while no significant incidence difference was observed in the individual cancer. Multivariate Cox regression analysis revealed that the imbalanced patient distribution (more elderly patients in group A than in group B), but not alogliptin usage per se, contributed to cancer development. The incidence of other major AE categories was with no between-group difference. Between-group difference was not detected, either, in the incidence of microvascular and macrovascular complications. HbA1c and fasting glucose decreased significantly at the 0.5-year visit and nearly plateaued thereafter in both groups.Conclusions Alogliptin as a representative of DPP-4 inhibitors was safe and durably efficacious when used alone or with other OHAs for patients with type 2 diabetes in the real world setting. Diseases of the endocrine glands. Clinical endocrinology Hirohito Sone verfasserin aut Haruhiko Osawa verfasserin aut Daisuke Koya verfasserin aut Takanori Miura verfasserin aut Yoshihito Atsumi verfasserin aut Udai Nakamura verfasserin aut Eiichi Araki verfasserin aut Hitoshi Shimano verfasserin aut Yukio Tanizawa verfasserin aut Jiro Nakamura verfasserin aut Yuichiro Yamada verfasserin aut Nobuya Inagaki verfasserin aut Atsuko Abiko verfasserin aut Hideki Katagiri verfasserin aut Michio Hayashi verfasserin aut Keiko Naruse verfasserin aut Shimpei Fujimoto verfasserin aut Masazumi Fujiwara verfasserin aut Kenichi Shikata verfasserin aut Yosuke Okada verfasserin aut Tsutomu Yamazaki verfasserin aut Sou Nagai verfasserin aut Katsuyuki Yanagisawa verfasserin aut Hiromichi Kijima verfasserin aut Shinji Taneda verfasserin aut Shigeyuki Saitoh verfasserin aut Daisuke Ikeda verfasserin aut Fuminori Hirano verfasserin aut Haruhiko Yoshimura verfasserin aut Mitsutaka Inoue verfasserin aut Masahiko Katoh verfasserin aut Osamu Nakagaki verfasserin aut Chiho Yamamoto verfasserin aut Akitsuki Morikawa verfasserin aut Shin Furukawa verfasserin aut Takeshi Koshiya verfasserin aut Hajime Sugawara verfasserin aut Takumi Uchida verfasserin aut Noe Takakubo verfasserin aut Yasushi Ishigaki verfasserin aut Susumu Suzuki verfasserin aut Takashi Shimotomai verfasserin aut Naoki Tamasawa verfasserin aut Jun Matsui verfasserin aut Takashi Goto verfasserin aut Toshihide Oizumi verfasserin aut Shinji Susa verfasserin aut Makoto Daimon verfasserin aut Hiroshi Murakami verfasserin aut Takashi Sugawara verfasserin aut Hiroaki Akai verfasserin aut Mari Nakamura verfasserin aut Yoshiji Ogawa verfasserin aut Takao Yokoshima verfasserin aut Tsuyoshi Watanabe verfasserin aut Michio Shimabukuro verfasserin aut Kazuhisa Tsukamoto verfasserin aut Motoei Kunimi verfasserin aut Jo Satoh verfasserin aut Atushi Okuyama verfasserin aut Kazutaka Ogawa verfasserin aut Hideyuki Eguchi verfasserin aut Mamoru Kimura verfasserin aut Hiroshi Kouno verfasserin aut Yohei Horikawa verfasserin aut Shin Ikejima verfasserin aut Masaru Saitoh verfasserin aut Naoyoshi Minami verfasserin aut Akihiro Sekikawa verfasserin aut Toyoyoshi Uchida verfasserin aut Toshihide Kawai verfasserin aut Nobuya Fujita verfasserin aut Ken Tomotsune verfasserin aut Shigeo Yamashita verfasserin aut Motoji Naka verfasserin aut Toru Hiyoshi verfasserin aut Tomotaka Katoh verfasserin aut Kumiko Hamano verfasserin aut Kouichi Inukai verfasserin aut Takuma Kondo verfasserin aut Kazuhiro Tsumura verfasserin aut Yoko Matsuzawa verfasserin aut Masahiro Mimura verfasserin aut Masahiko Kawasumi verfasserin aut Izumi Takei verfasserin aut Masafumi Matsuda verfasserin aut Ichiro Tatsuno verfasserin aut Nobuyuki Banba verfasserin aut Akihiko Ando verfasserin aut Masao Toyoda verfasserin aut Daisuke Suzuki verfasserin aut Takahiro Iijima verfasserin aut Yasumichi Mori verfasserin aut Yutaka Uehara verfasserin aut Yoshihiko Satoh verfasserin aut Kazuaki Yahata verfasserin aut Yoshimasa Asoh verfasserin aut Koichiro Kuwabara verfasserin aut Souichi Takizawa verfasserin aut Yasushi Tanaka verfasserin aut Koutaroh Yokote verfasserin aut Masako Tohgo verfasserin aut Takanobu Itoi verfasserin aut Shigeru Miyazaki verfasserin aut Hiroshi Itoh verfasserin aut Teruo Shiba verfasserin aut Takahisa Hirose verfasserin aut Mariko Higa verfasserin aut Masanobu Yamada verfasserin aut Osamu Ogawa verfasserin aut Masatoshi Kuroki verfasserin aut Shinobu Satoh verfasserin aut Makoto Ujihara verfasserin aut Kenjiroh Yamanaka verfasserin aut Hajime Koyano verfasserin aut Tadashi Yamakawa verfasserin aut Kenichiroh Takahashi verfasserin aut Kazuki Orime verfasserin aut Tsutomu Hirano verfasserin aut Jiroh Morimoto verfasserin aut Takashi Itoh verfasserin aut Yuzoh Mizuno verfasserin aut Naoyuki Yamamoto verfasserin aut Han Miyatake verfasserin aut Mina Yamaguchi verfasserin aut Kenji Yamane verfasserin aut Masahiko Kure verfasserin aut Satoko Kawabe verfasserin aut Masahumi Kakei verfasserin aut Masashi Yoshida verfasserin aut Hiroyuki Itoh verfasserin aut Nobuaki Minami verfasserin aut Kazuki Kobayashi verfasserin aut Yusuke Fujino verfasserin aut Makoto Shibuya verfasserin aut Midori Hosokawa verfasserin aut Isao Nozaki verfasserin aut Chigure Nawa verfasserin aut Tamio Ieiri verfasserin aut Takayuki Watanabe verfasserin aut Yoshio Katoh verfasserin aut Takuyuki Katabami verfasserin aut Michiko Handa verfasserin aut Issei Shimada verfasserin aut Kenichi Ohya verfasserin aut Yoshihiro Ogawa verfasserin aut Takanobu Yoshimoto verfasserin aut Jiroh Nakamura verfasserin aut Naotsuka Okayama verfasserin aut Kenro Imaeda verfasserin aut Syuko Yoshioka verfasserin aut Masako Murakami verfasserin aut Takashi Murase verfasserin aut Yoshihiko Yamada verfasserin aut Yutaka Yano verfasserin aut Hiromitsu Sasaki verfasserin aut Yasuhiro Sumida verfasserin aut Osamu Yonaha verfasserin aut Hiroshi Sobajima verfasserin aut Mitsuyasu Ito verfasserin aut Atushi Suzuki verfasserin aut Atsuko Ishikawa verfasserin aut Takehiko Ichikawa verfasserin aut Shogo Asano verfasserin aut Shinobu Goto verfasserin aut Sakuma Hiroya verfasserin aut Hiroshi Murase verfasserin aut Shozo Ogawa verfasserin aut Hideki Okamoto verfasserin aut Kotaro Nagai verfasserin aut Koji Nagayama verfasserin aut Masanori Yoshida verfasserin aut Norio Takahashi verfasserin aut Kazuhisa Takami verfasserin aut Tsuneo Ono verfasserin aut Takanobu Morihiro verfasserin aut Daisuke Tanaka verfasserin aut Noriko Takahara verfasserin aut Satoshi Miyata verfasserin aut Mamiko Tsugawa verfasserin aut Koichiro Yasuda verfasserin aut Seiji Muro verfasserin aut Masanori Emoto verfasserin aut Ikuo Mineo verfasserin aut Ichiro Shiojima verfasserin aut Takeshi Kurose verfasserin aut Makoto Ohashi verfasserin aut Yumiko Kawabata verfasserin aut Mitsushige Nishikawa verfasserin aut Emiko Nomura verfasserin aut Yasuyuki Nishimura verfasserin aut Yasuhiro Ono verfasserin aut Yasuhisa Yamamoto verfasserin aut Keigo Naka verfasserin aut Taizo Yamamoto verfasserin aut Rika Usuda verfasserin aut Hiroshi Akahori verfasserin aut Seika Kato verfasserin aut Hiroyuki Konya verfasserin aut Yutaka Umayahara verfasserin aut Takashi Seta verfasserin aut Hideki Taki verfasserin aut Masashi Sekiya verfasserin aut Shinichi Mogami verfasserin aut Sumie Fujii verfasserin aut Toshiyuki Hibuse verfasserin aut Shingo Tsuji verfasserin aut Hirofumi Sumi verfasserin aut Yasuro Kumeda verfasserin aut Akinori Kogure verfasserin aut Kenji Furukawa verfasserin aut Akira Kuroe verfasserin aut Hideaki Sawaki verfasserin aut Narihiro Hibiki verfasserin aut Yoshihiro Kitagawa verfasserin aut Yukihiro Bando verfasserin aut Akira Ono verfasserin aut Rikako Uenaka verfasserin aut Seitaro Omoto verfasserin aut Yuki Kita verfasserin aut Eiko Ri verfasserin aut Ryutaro Numaguchi verfasserin aut Sachiko Kawashima verfasserin aut Ichiro Kisimoto verfasserin aut Kiminori Hosoda verfasserin aut Yoshihiko Araki verfasserin aut Tetsuroh Arimura verfasserin aut Mitsuru Hashiramoto verfasserin aut Koumei Takeda verfasserin aut Akira Matsutani verfasserin aut Yasushi Inoue verfasserin aut Fumio Sawano verfasserin aut Nozomu Kamei verfasserin aut Yasuo Ito verfasserin aut Miwa Morita verfasserin aut Yoshiaki Oda verfasserin aut Rui Kishimoto verfasserin aut Katsuhiro Hatao verfasserin aut Tomoatsu Mune verfasserin aut Fumiko Kawasaki verfasserin aut Hiroki Teragawa verfasserin aut Ken Yaga verfasserin aut Keita Ishii verfasserin aut Kyouji Hirata verfasserin aut Tatsuaki Nakatou verfasserin aut Yutaka Nitta verfasserin aut Naoki Fujita verfasserin aut Masayasu Yoneda verfasserin aut Masatoshi Tsuru verfasserin aut Shinichirou Ando verfasserin aut Toshiaki Kakiba verfasserin aut Michihiro Toyoshige verfasserin aut Tsuguka Shiwa verfasserin aut Hiroaki Miyaoka verfasserin aut Yasumi Shintani verfasserin aut Takenori Sakai verfasserin aut Tetsuji Niiya verfasserin aut Shinpei Fujimoto verfasserin aut Hisaka Minami verfasserin aut Yoshihiko Noma verfasserin aut Masaaki Tamaru verfasserin aut Yoshitaka Sayou verfasserin aut Tomoyo Oyama verfasserin aut Masamoto Torisu verfasserin aut Yuichi Fujinaka verfasserin aut Yoshitaka Kumon verfasserin aut Shozo Miyauchi verfasserin aut Morikazu Onji verfasserin aut Toru Nakamura verfasserin aut Yousuke Okada verfasserin aut Toshihiko Yanase verfasserin aut Kenro Nishida verfasserin aut Syuji Nakamura verfasserin aut Kunihisa Kobayashi verfasserin aut Nobuhiko Wada verfasserin aut Moritake Higa verfasserin aut Koji Matsushita verfasserin aut Yoshihiko Nishio verfasserin aut Ryoji Fujimoto verfasserin aut Yasuyuki Kihara verfasserin aut Shinichiro Mine verfasserin aut Tadashi Arao verfasserin aut Hiromi Tasaki verfasserin aut Yasuto Matsuo verfasserin aut Hirofumi Matsuda verfasserin aut Kohei Uriu verfasserin aut Kazuko Kanda verfasserin aut Kazuo Ibaraki verfasserin aut Yoshio Kaku verfasserin aut Yasuhiro Takaki verfasserin aut Iwaho Hazekawa verfasserin aut Kenji Ebihara verfasserin aut Eiichiro Watanabe verfasserin aut Iku Sakurada verfasserin aut Kazuhisa Muraishi verfasserin aut Tamami Oshige verfasserin aut Junichi Yasuda verfasserin aut Toyoshi Iguchi verfasserin aut Noriyuki Sonoda verfasserin aut Masahiro Adachi verfasserin aut Isao Ichino verfasserin aut Yuko Horiuchi verfasserin aut Souichi Uekihara verfasserin aut Shingo Morimitsu verfasserin aut Mitsuhiro Nakazawa verfasserin aut Tadashi Seguchi verfasserin aut Kengo Kaneko verfasserin aut In BMJ Open Diabetes Research & Care BMJ Publishing Group, 2016 9(2021), 1 (DE-627)768094542 (DE-600)2732918-5 20524897 nnns volume:9 year:2021 number:1 https://doi.org/10.1136/bmjdrc-2020-001787 kostenfrei https://doaj.org/article/9dc90dc2c997472e81cb2c1c6cd779d5 kostenfrei https://drc.bmj.com/content/9/1/e001787.full kostenfrei https://doaj.org/toc/2052-4897 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 1
spelling	10.1136/bmjdrc-2020-001787 doi (DE-627)DOAJ002062054 (DE-599)DOAJ9dc90dc2c997472e81cb2c1c6cd779d5 DE-627 ger DE-627 rakwb eng RC648-665 Masakazu Kobayashi verfasserin aut Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction Given an increasing use of dipeptidyl peptidase-4 (DPP-4) inhibitors to treat patients with type 2 diabetes mellitus in the real-world setting, we conducted a prospective observational study (Japan-based Clinical Research Network for Diabetes Registry: J-BRAND Registry) to elucidate the safety and efficacy profile of long-term usage of alogliptin.Research design and methods We registered 5969 patients from April 2012 through September 2014, who started receiving alogliptin (group A) or other classes of oral hypoglycemic agents (OHAs; group B), and were followed for 3 years at 239 sites nationwide. Safety was the primary outcome. Symptomatic hypoglycemia, pancreatitis, skin disorders of non-extrinsic origin, severe infections, and cancer were collected as major adverse events (AEs). Efficacy assessment was the secondary outcome and included changes in hemoglobin A1c (HbA1c), fasting blood glucose, fasting insulin and urinary albumin.Results Of the registered, 5150 (group A: 3395 and group B: 1755) and 5096 (3358 and 1738) were included for safety and efficacy analysis, respectively. Group A patients mostly (>90%) continued to use alogliptin. In group B, biguanides were the primary agents, while DPP-4 inhibitors were added in up to ~36% of patients. The overall incidence of AEs was similar between the two groups (42.7% vs 42.2%). Kaplan-Meier analysis revealed the incidence of cancer was significantly higher in group A than in group B (7.4% vs 4.8%, p=0.040), while no significant incidence difference was observed in the individual cancer. Multivariate Cox regression analysis revealed that the imbalanced patient distribution (more elderly patients in group A than in group B), but not alogliptin usage per se, contributed to cancer development. The incidence of other major AE categories was with no between-group difference. Between-group difference was not detected, either, in the incidence of microvascular and macrovascular complications. HbA1c and fasting glucose decreased significantly at the 0.5-year visit and nearly plateaued thereafter in both groups.Conclusions Alogliptin as a representative of DPP-4 inhibitors was safe and durably efficacious when used alone or with other OHAs for patients with type 2 diabetes in the real world setting. Diseases of the endocrine glands. Clinical endocrinology Hirohito Sone verfasserin aut Haruhiko Osawa verfasserin aut Daisuke Koya verfasserin aut Takanori Miura verfasserin aut Yoshihito Atsumi verfasserin aut Udai Nakamura verfasserin aut Eiichi Araki verfasserin aut Hitoshi Shimano verfasserin aut Yukio Tanizawa verfasserin aut Jiro Nakamura verfasserin aut Yuichiro Yamada verfasserin aut Nobuya Inagaki verfasserin aut Atsuko Abiko verfasserin aut Hideki Katagiri verfasserin aut Michio Hayashi verfasserin aut Keiko Naruse verfasserin aut Shimpei Fujimoto verfasserin aut Masazumi Fujiwara verfasserin aut Kenichi Shikata verfasserin aut Yosuke Okada verfasserin aut Tsutomu Yamazaki verfasserin aut Sou Nagai verfasserin aut Katsuyuki Yanagisawa verfasserin aut Hiromichi Kijima verfasserin aut Shinji Taneda verfasserin aut Shigeyuki Saitoh verfasserin aut Daisuke Ikeda verfasserin aut Fuminori Hirano verfasserin aut Haruhiko Yoshimura verfasserin aut Mitsutaka Inoue verfasserin aut Masahiko Katoh verfasserin aut Osamu Nakagaki verfasserin aut Chiho Yamamoto verfasserin aut Akitsuki Morikawa verfasserin aut Shin Furukawa verfasserin aut Takeshi Koshiya verfasserin aut Hajime Sugawara verfasserin aut Takumi Uchida verfasserin aut Noe Takakubo verfasserin aut Yasushi Ishigaki verfasserin aut Susumu Suzuki verfasserin aut Takashi Shimotomai verfasserin aut Naoki Tamasawa verfasserin aut Jun Matsui verfasserin aut Takashi Goto verfasserin aut Toshihide Oizumi verfasserin aut Shinji Susa verfasserin aut Makoto Daimon verfasserin aut Hiroshi Murakami verfasserin aut Takashi Sugawara verfasserin aut Hiroaki Akai verfasserin aut Mari Nakamura verfasserin aut Yoshiji Ogawa verfasserin aut Takao Yokoshima verfasserin aut Tsuyoshi Watanabe verfasserin aut Michio Shimabukuro verfasserin aut Kazuhisa Tsukamoto verfasserin aut Motoei Kunimi verfasserin aut Jo Satoh verfasserin aut Atushi Okuyama verfasserin aut Kazutaka Ogawa verfasserin aut Hideyuki Eguchi verfasserin aut Mamoru Kimura verfasserin aut Hiroshi Kouno verfasserin aut Yohei Horikawa verfasserin aut Shin Ikejima verfasserin aut Masaru Saitoh verfasserin aut Naoyoshi Minami verfasserin aut Akihiro Sekikawa verfasserin aut Toyoyoshi Uchida verfasserin aut Toshihide Kawai verfasserin aut Nobuya Fujita verfasserin aut Ken Tomotsune verfasserin aut Shigeo Yamashita verfasserin aut Motoji Naka verfasserin aut Toru Hiyoshi verfasserin aut Tomotaka Katoh verfasserin aut Kumiko Hamano verfasserin aut Kouichi Inukai verfasserin aut Takuma Kondo verfasserin aut Kazuhiro Tsumura verfasserin aut Yoko Matsuzawa verfasserin aut Masahiro Mimura verfasserin aut Masahiko Kawasumi verfasserin aut Izumi Takei verfasserin aut Masafumi Matsuda verfasserin aut Ichiro Tatsuno verfasserin aut Nobuyuki Banba verfasserin aut Akihiko Ando verfasserin aut Masao Toyoda verfasserin aut Daisuke Suzuki verfasserin aut Takahiro Iijima verfasserin aut Yasumichi Mori verfasserin aut Yutaka Uehara verfasserin aut Yoshihiko Satoh verfasserin aut Kazuaki Yahata verfasserin aut Yoshimasa Asoh verfasserin aut Koichiro Kuwabara verfasserin aut Souichi Takizawa verfasserin aut Yasushi Tanaka verfasserin aut Koutaroh Yokote verfasserin aut Masako Tohgo verfasserin aut Takanobu Itoi verfasserin aut Shigeru Miyazaki verfasserin aut Hiroshi Itoh verfasserin aut Teruo Shiba verfasserin aut Takahisa Hirose verfasserin aut Mariko Higa verfasserin aut Masanobu Yamada verfasserin aut Osamu Ogawa verfasserin aut Masatoshi Kuroki verfasserin aut Shinobu Satoh verfasserin aut Makoto Ujihara verfasserin aut Kenjiroh Yamanaka verfasserin aut Hajime Koyano verfasserin aut Tadashi Yamakawa verfasserin aut Kenichiroh Takahashi verfasserin aut Kazuki Orime verfasserin aut Tsutomu Hirano verfasserin aut Jiroh Morimoto verfasserin aut Takashi Itoh verfasserin aut Yuzoh Mizuno verfasserin aut Naoyuki Yamamoto verfasserin aut Han Miyatake verfasserin aut Mina Yamaguchi verfasserin aut Kenji Yamane verfasserin aut Masahiko Kure verfasserin aut Satoko Kawabe verfasserin aut Masahumi Kakei verfasserin aut Masashi Yoshida verfasserin aut Hiroyuki Itoh verfasserin aut Nobuaki Minami verfasserin aut Kazuki Kobayashi verfasserin aut Yusuke Fujino verfasserin aut Makoto Shibuya verfasserin aut Midori Hosokawa verfasserin aut Isao Nozaki verfasserin aut Chigure Nawa verfasserin aut Tamio Ieiri verfasserin aut Takayuki Watanabe verfasserin aut Yoshio Katoh verfasserin aut Takuyuki Katabami verfasserin aut Michiko Handa verfasserin aut Issei Shimada verfasserin aut Kenichi Ohya verfasserin aut Yoshihiro Ogawa verfasserin aut Takanobu Yoshimoto verfasserin aut Jiroh Nakamura verfasserin aut Naotsuka Okayama verfasserin aut Kenro Imaeda verfasserin aut Syuko Yoshioka verfasserin aut Masako Murakami verfasserin aut Takashi Murase verfasserin aut Yoshihiko Yamada verfasserin aut Yutaka Yano verfasserin aut Hiromitsu Sasaki verfasserin aut Yasuhiro Sumida verfasserin aut Osamu Yonaha verfasserin aut Hiroshi Sobajima verfasserin aut Mitsuyasu Ito verfasserin aut Atushi Suzuki verfasserin aut Atsuko Ishikawa verfasserin aut Takehiko Ichikawa verfasserin aut Shogo Asano verfasserin aut Shinobu Goto verfasserin aut Sakuma Hiroya verfasserin aut Hiroshi Murase verfasserin aut Shozo Ogawa verfasserin aut Hideki Okamoto verfasserin aut Kotaro Nagai verfasserin aut Koji Nagayama verfasserin aut Masanori Yoshida verfasserin aut Norio Takahashi verfasserin aut Kazuhisa Takami verfasserin aut Tsuneo Ono verfasserin aut Takanobu Morihiro verfasserin aut Daisuke Tanaka verfasserin aut Noriko Takahara verfasserin aut Satoshi Miyata verfasserin aut Mamiko Tsugawa verfasserin aut Koichiro Yasuda verfasserin aut Seiji Muro verfasserin aut Masanori Emoto verfasserin aut Ikuo Mineo verfasserin aut Ichiro Shiojima verfasserin aut Takeshi Kurose verfasserin aut Makoto Ohashi verfasserin aut Yumiko Kawabata verfasserin aut Mitsushige Nishikawa verfasserin aut Emiko Nomura verfasserin aut Yasuyuki Nishimura verfasserin aut Yasuhiro Ono verfasserin aut Yasuhisa Yamamoto verfasserin aut Keigo Naka verfasserin aut Taizo Yamamoto verfasserin aut Rika Usuda verfasserin aut Hiroshi Akahori verfasserin aut Seika Kato verfasserin aut Hiroyuki Konya verfasserin aut Yutaka Umayahara verfasserin aut Takashi Seta verfasserin aut Hideki Taki verfasserin aut Masashi Sekiya verfasserin aut Shinichi Mogami verfasserin aut Sumie Fujii verfasserin aut Toshiyuki Hibuse verfasserin aut Shingo Tsuji verfasserin aut Hirofumi Sumi verfasserin aut Yasuro Kumeda verfasserin aut Akinori Kogure verfasserin aut Kenji Furukawa verfasserin aut Akira Kuroe verfasserin aut Hideaki Sawaki verfasserin aut Narihiro Hibiki verfasserin aut Yoshihiro Kitagawa verfasserin aut Yukihiro Bando verfasserin aut Akira Ono verfasserin aut Rikako Uenaka verfasserin aut Seitaro Omoto verfasserin aut Yuki Kita verfasserin aut Eiko Ri verfasserin aut Ryutaro Numaguchi verfasserin aut Sachiko Kawashima verfasserin aut Ichiro Kisimoto verfasserin aut Kiminori Hosoda verfasserin aut Yoshihiko Araki verfasserin aut Tetsuroh Arimura verfasserin aut Mitsuru Hashiramoto verfasserin aut Koumei Takeda verfasserin aut Akira Matsutani verfasserin aut Yasushi Inoue verfasserin aut Fumio Sawano verfasserin aut Nozomu Kamei verfasserin aut Yasuo Ito verfasserin aut Miwa Morita verfasserin aut Yoshiaki Oda verfasserin aut Rui Kishimoto verfasserin aut Katsuhiro Hatao verfasserin aut Tomoatsu Mune verfasserin aut Fumiko Kawasaki verfasserin aut Hiroki Teragawa verfasserin aut Ken Yaga verfasserin aut Keita Ishii verfasserin aut Kyouji Hirata verfasserin aut Tatsuaki Nakatou verfasserin aut Yutaka Nitta verfasserin aut Naoki Fujita verfasserin aut Masayasu Yoneda verfasserin aut Masatoshi Tsuru verfasserin aut Shinichirou Ando verfasserin aut Toshiaki Kakiba verfasserin aut Michihiro Toyoshige verfasserin aut Tsuguka Shiwa verfasserin aut Hiroaki Miyaoka verfasserin aut Yasumi Shintani verfasserin aut Takenori Sakai verfasserin aut Tetsuji Niiya verfasserin aut Shinpei Fujimoto verfasserin aut Hisaka Minami verfasserin aut Yoshihiko Noma verfasserin aut Masaaki Tamaru verfasserin aut Yoshitaka Sayou verfasserin aut Tomoyo Oyama verfasserin aut Masamoto Torisu verfasserin aut Yuichi Fujinaka verfasserin aut Yoshitaka Kumon verfasserin aut Shozo Miyauchi verfasserin aut Morikazu Onji verfasserin aut Toru Nakamura verfasserin aut Yousuke Okada verfasserin aut Toshihiko Yanase verfasserin aut Kenro Nishida verfasserin aut Syuji Nakamura verfasserin aut Kunihisa Kobayashi verfasserin aut Nobuhiko Wada verfasserin aut Moritake Higa verfasserin aut Koji Matsushita verfasserin aut Yoshihiko Nishio verfasserin aut Ryoji Fujimoto verfasserin aut Yasuyuki Kihara verfasserin aut Shinichiro Mine verfasserin aut Tadashi Arao verfasserin aut Hiromi Tasaki verfasserin aut Yasuto Matsuo verfasserin aut Hirofumi Matsuda verfasserin aut Kohei Uriu verfasserin aut Kazuko Kanda verfasserin aut Kazuo Ibaraki verfasserin aut Yoshio Kaku verfasserin aut Yasuhiro Takaki verfasserin aut Iwaho Hazekawa verfasserin aut Kenji Ebihara verfasserin aut Eiichiro Watanabe verfasserin aut Iku Sakurada verfasserin aut Kazuhisa Muraishi verfasserin aut Tamami Oshige verfasserin aut Junichi Yasuda verfasserin aut Toyoshi Iguchi verfasserin aut Noriyuki Sonoda verfasserin aut Masahiro Adachi verfasserin aut Isao Ichino verfasserin aut Yuko Horiuchi verfasserin aut Souichi Uekihara verfasserin aut Shingo Morimitsu verfasserin aut Mitsuhiro Nakazawa verfasserin aut Tadashi Seguchi verfasserin aut Kengo Kaneko verfasserin aut In BMJ Open Diabetes Research & Care BMJ Publishing Group, 2016 9(2021), 1 (DE-627)768094542 (DE-600)2732918-5 20524897 nnns volume:9 year:2021 number:1 https://doi.org/10.1136/bmjdrc-2020-001787 kostenfrei https://doaj.org/article/9dc90dc2c997472e81cb2c1c6cd779d5 kostenfrei https://drc.bmj.com/content/9/1/e001787.full kostenfrei https://doaj.org/toc/2052-4897 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 1
allfields_unstemmed	10.1136/bmjdrc-2020-001787 doi (DE-627)DOAJ002062054 (DE-599)DOAJ9dc90dc2c997472e81cb2c1c6cd779d5 DE-627 ger DE-627 rakwb eng RC648-665 Masakazu Kobayashi verfasserin aut Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction Given an increasing use of dipeptidyl peptidase-4 (DPP-4) inhibitors to treat patients with type 2 diabetes mellitus in the real-world setting, we conducted a prospective observational study (Japan-based Clinical Research Network for Diabetes Registry: J-BRAND Registry) to elucidate the safety and efficacy profile of long-term usage of alogliptin.Research design and methods We registered 5969 patients from April 2012 through September 2014, who started receiving alogliptin (group A) or other classes of oral hypoglycemic agents (OHAs; group B), and were followed for 3 years at 239 sites nationwide. Safety was the primary outcome. Symptomatic hypoglycemia, pancreatitis, skin disorders of non-extrinsic origin, severe infections, and cancer were collected as major adverse events (AEs). Efficacy assessment was the secondary outcome and included changes in hemoglobin A1c (HbA1c), fasting blood glucose, fasting insulin and urinary albumin.Results Of the registered, 5150 (group A: 3395 and group B: 1755) and 5096 (3358 and 1738) were included for safety and efficacy analysis, respectively. Group A patients mostly (>90%) continued to use alogliptin. In group B, biguanides were the primary agents, while DPP-4 inhibitors were added in up to ~36% of patients. The overall incidence of AEs was similar between the two groups (42.7% vs 42.2%). Kaplan-Meier analysis revealed the incidence of cancer was significantly higher in group A than in group B (7.4% vs 4.8%, p=0.040), while no significant incidence difference was observed in the individual cancer. Multivariate Cox regression analysis revealed that the imbalanced patient distribution (more elderly patients in group A than in group B), but not alogliptin usage per se, contributed to cancer development. The incidence of other major AE categories was with no between-group difference. Between-group difference was not detected, either, in the incidence of microvascular and macrovascular complications. HbA1c and fasting glucose decreased significantly at the 0.5-year visit and nearly plateaued thereafter in both groups.Conclusions Alogliptin as a representative of DPP-4 inhibitors was safe and durably efficacious when used alone or with other OHAs for patients with type 2 diabetes in the real world setting. Diseases of the endocrine glands. Clinical endocrinology Hirohito Sone verfasserin aut Haruhiko Osawa verfasserin aut Daisuke Koya verfasserin aut Takanori Miura verfasserin aut Yoshihito Atsumi verfasserin aut Udai Nakamura verfasserin aut Eiichi Araki verfasserin aut Hitoshi Shimano verfasserin aut Yukio Tanizawa verfasserin aut Jiro Nakamura verfasserin aut Yuichiro Yamada verfasserin aut Nobuya Inagaki verfasserin aut Atsuko Abiko verfasserin aut Hideki Katagiri verfasserin aut Michio Hayashi verfasserin aut Keiko Naruse verfasserin aut Shimpei Fujimoto verfasserin aut Masazumi Fujiwara verfasserin aut Kenichi Shikata verfasserin aut Yosuke Okada verfasserin aut Tsutomu Yamazaki verfasserin aut Sou Nagai verfasserin aut Katsuyuki Yanagisawa verfasserin aut Hiromichi Kijima verfasserin aut Shinji Taneda verfasserin aut Shigeyuki Saitoh verfasserin aut Daisuke Ikeda verfasserin aut Fuminori Hirano verfasserin aut Haruhiko Yoshimura verfasserin aut Mitsutaka Inoue verfasserin aut Masahiko Katoh verfasserin aut Osamu Nakagaki verfasserin aut Chiho Yamamoto verfasserin aut Akitsuki Morikawa verfasserin aut Shin Furukawa verfasserin aut Takeshi Koshiya verfasserin aut Hajime Sugawara verfasserin aut Takumi Uchida verfasserin aut Noe Takakubo verfasserin aut Yasushi Ishigaki verfasserin aut Susumu Suzuki verfasserin aut Takashi Shimotomai verfasserin aut Naoki Tamasawa verfasserin aut Jun Matsui verfasserin aut Takashi Goto verfasserin aut Toshihide Oizumi verfasserin aut Shinji Susa verfasserin aut Makoto Daimon verfasserin aut Hiroshi Murakami verfasserin aut Takashi Sugawara verfasserin aut Hiroaki Akai verfasserin aut Mari Nakamura verfasserin aut Yoshiji Ogawa verfasserin aut Takao Yokoshima verfasserin aut Tsuyoshi Watanabe verfasserin aut Michio Shimabukuro verfasserin aut Kazuhisa Tsukamoto verfasserin aut Motoei Kunimi verfasserin aut Jo Satoh verfasserin aut Atushi Okuyama verfasserin aut Kazutaka Ogawa verfasserin aut Hideyuki Eguchi verfasserin aut Mamoru Kimura verfasserin aut Hiroshi Kouno verfasserin aut Yohei Horikawa verfasserin aut Shin Ikejima verfasserin aut Masaru Saitoh verfasserin aut Naoyoshi Minami verfasserin aut Akihiro Sekikawa verfasserin aut Toyoyoshi Uchida verfasserin aut Toshihide Kawai verfasserin aut Nobuya Fujita verfasserin aut Ken Tomotsune verfasserin aut Shigeo Yamashita verfasserin aut Motoji Naka verfasserin aut Toru Hiyoshi verfasserin aut Tomotaka Katoh verfasserin aut Kumiko Hamano verfasserin aut Kouichi Inukai verfasserin aut Takuma Kondo verfasserin aut Kazuhiro Tsumura verfasserin aut Yoko Matsuzawa verfasserin aut Masahiro Mimura verfasserin aut Masahiko Kawasumi verfasserin aut Izumi Takei verfasserin aut Masafumi Matsuda verfasserin aut Ichiro Tatsuno verfasserin aut Nobuyuki Banba verfasserin aut Akihiko Ando verfasserin aut Masao Toyoda verfasserin aut Daisuke Suzuki verfasserin aut Takahiro Iijima verfasserin aut Yasumichi Mori verfasserin aut Yutaka Uehara verfasserin aut Yoshihiko Satoh verfasserin aut Kazuaki Yahata verfasserin aut Yoshimasa Asoh verfasserin aut Koichiro Kuwabara verfasserin aut Souichi Takizawa verfasserin aut Yasushi Tanaka verfasserin aut Koutaroh Yokote verfasserin aut Masako Tohgo verfasserin aut Takanobu Itoi verfasserin aut Shigeru Miyazaki verfasserin aut Hiroshi Itoh verfasserin aut Teruo Shiba verfasserin aut Takahisa Hirose verfasserin aut Mariko Higa verfasserin aut Masanobu Yamada verfasserin aut Osamu Ogawa verfasserin aut Masatoshi Kuroki verfasserin aut Shinobu Satoh verfasserin aut Makoto Ujihara verfasserin aut Kenjiroh Yamanaka verfasserin aut Hajime Koyano verfasserin aut Tadashi Yamakawa verfasserin aut Kenichiroh Takahashi verfasserin aut Kazuki Orime verfasserin aut Tsutomu Hirano verfasserin aut Jiroh Morimoto verfasserin aut Takashi Itoh verfasserin aut Yuzoh Mizuno verfasserin aut Naoyuki Yamamoto verfasserin aut Han Miyatake verfasserin aut Mina Yamaguchi verfasserin aut Kenji Yamane verfasserin aut Masahiko Kure verfasserin aut Satoko Kawabe verfasserin aut Masahumi Kakei verfasserin aut Masashi Yoshida verfasserin aut Hiroyuki Itoh verfasserin aut Nobuaki Minami verfasserin aut Kazuki Kobayashi verfasserin aut Yusuke Fujino verfasserin aut Makoto Shibuya verfasserin aut Midori Hosokawa verfasserin aut Isao Nozaki verfasserin aut Chigure Nawa verfasserin aut Tamio Ieiri verfasserin aut Takayuki Watanabe verfasserin aut Yoshio Katoh verfasserin aut Takuyuki Katabami verfasserin aut Michiko Handa verfasserin aut Issei Shimada verfasserin aut Kenichi Ohya verfasserin aut Yoshihiro Ogawa verfasserin aut Takanobu Yoshimoto verfasserin aut Jiroh Nakamura verfasserin aut Naotsuka Okayama verfasserin aut Kenro Imaeda verfasserin aut Syuko Yoshioka verfasserin aut Masako Murakami verfasserin aut Takashi Murase verfasserin aut Yoshihiko Yamada verfasserin aut Yutaka Yano verfasserin aut Hiromitsu Sasaki verfasserin aut Yasuhiro Sumida verfasserin aut Osamu Yonaha verfasserin aut Hiroshi Sobajima verfasserin aut Mitsuyasu Ito verfasserin aut Atushi Suzuki verfasserin aut Atsuko Ishikawa verfasserin aut Takehiko Ichikawa verfasserin aut Shogo Asano verfasserin aut Shinobu Goto verfasserin aut Sakuma Hiroya verfasserin aut Hiroshi Murase verfasserin aut Shozo Ogawa verfasserin aut Hideki Okamoto verfasserin aut Kotaro Nagai verfasserin aut Koji Nagayama verfasserin aut Masanori Yoshida verfasserin aut Norio Takahashi verfasserin aut Kazuhisa Takami verfasserin aut Tsuneo Ono verfasserin aut Takanobu Morihiro verfasserin aut Daisuke Tanaka verfasserin aut Noriko Takahara verfasserin aut Satoshi Miyata verfasserin aut Mamiko Tsugawa verfasserin aut Koichiro Yasuda verfasserin aut Seiji Muro verfasserin aut Masanori Emoto verfasserin aut Ikuo Mineo verfasserin aut Ichiro Shiojima verfasserin aut Takeshi Kurose verfasserin aut Makoto Ohashi verfasserin aut Yumiko Kawabata verfasserin aut Mitsushige Nishikawa verfasserin aut Emiko Nomura verfasserin aut Yasuyuki Nishimura verfasserin aut Yasuhiro Ono verfasserin aut Yasuhisa Yamamoto verfasserin aut Keigo Naka verfasserin aut Taizo Yamamoto verfasserin aut Rika Usuda verfasserin aut Hiroshi Akahori verfasserin aut Seika Kato verfasserin aut Hiroyuki Konya verfasserin aut Yutaka Umayahara verfasserin aut Takashi Seta verfasserin aut Hideki Taki verfasserin aut Masashi Sekiya verfasserin aut Shinichi Mogami verfasserin aut Sumie Fujii verfasserin aut Toshiyuki Hibuse verfasserin aut Shingo Tsuji verfasserin aut Hirofumi Sumi verfasserin aut Yasuro Kumeda verfasserin aut Akinori Kogure verfasserin aut Kenji Furukawa verfasserin aut Akira Kuroe verfasserin aut Hideaki Sawaki verfasserin aut Narihiro Hibiki verfasserin aut Yoshihiro Kitagawa verfasserin aut Yukihiro Bando verfasserin aut Akira Ono verfasserin aut Rikako Uenaka verfasserin aut Seitaro Omoto verfasserin aut Yuki Kita verfasserin aut Eiko Ri verfasserin aut Ryutaro Numaguchi verfasserin aut Sachiko Kawashima verfasserin aut Ichiro Kisimoto verfasserin aut Kiminori Hosoda verfasserin aut Yoshihiko Araki verfasserin aut Tetsuroh Arimura verfasserin aut Mitsuru Hashiramoto verfasserin aut Koumei Takeda verfasserin aut Akira Matsutani verfasserin aut Yasushi Inoue verfasserin aut Fumio Sawano verfasserin aut Nozomu Kamei verfasserin aut Yasuo Ito verfasserin aut Miwa Morita verfasserin aut Yoshiaki Oda verfasserin aut Rui Kishimoto verfasserin aut Katsuhiro Hatao verfasserin aut Tomoatsu Mune verfasserin aut Fumiko Kawasaki verfasserin aut Hiroki Teragawa verfasserin aut Ken Yaga verfasserin aut Keita Ishii verfasserin aut Kyouji Hirata verfasserin aut Tatsuaki Nakatou verfasserin aut Yutaka Nitta verfasserin aut Naoki Fujita verfasserin aut Masayasu Yoneda verfasserin aut Masatoshi Tsuru verfasserin aut Shinichirou Ando verfasserin aut Toshiaki Kakiba verfasserin aut Michihiro Toyoshige verfasserin aut Tsuguka Shiwa verfasserin aut Hiroaki Miyaoka verfasserin aut Yasumi Shintani verfasserin aut Takenori Sakai verfasserin aut Tetsuji Niiya verfasserin aut Shinpei Fujimoto verfasserin aut Hisaka Minami verfasserin aut Yoshihiko Noma verfasserin aut Masaaki Tamaru verfasserin aut Yoshitaka Sayou verfasserin aut Tomoyo Oyama verfasserin aut Masamoto Torisu verfasserin aut Yuichi Fujinaka verfasserin aut Yoshitaka Kumon verfasserin aut Shozo Miyauchi verfasserin aut Morikazu Onji verfasserin aut Toru Nakamura verfasserin aut Yousuke Okada verfasserin aut Toshihiko Yanase verfasserin aut Kenro Nishida verfasserin aut Syuji Nakamura verfasserin aut Kunihisa Kobayashi verfasserin aut Nobuhiko Wada verfasserin aut Moritake Higa verfasserin aut Koji Matsushita verfasserin aut Yoshihiko Nishio verfasserin aut Ryoji Fujimoto verfasserin aut Yasuyuki Kihara verfasserin aut Shinichiro Mine verfasserin aut Tadashi Arao verfasserin aut Hiromi Tasaki verfasserin aut Yasuto Matsuo verfasserin aut Hirofumi Matsuda verfasserin aut Kohei Uriu verfasserin aut Kazuko Kanda verfasserin aut Kazuo Ibaraki verfasserin aut Yoshio Kaku verfasserin aut Yasuhiro Takaki verfasserin aut Iwaho Hazekawa verfasserin aut Kenji Ebihara verfasserin aut Eiichiro Watanabe verfasserin aut Iku Sakurada verfasserin aut Kazuhisa Muraishi verfasserin aut Tamami Oshige verfasserin aut Junichi Yasuda verfasserin aut Toyoshi Iguchi verfasserin aut Noriyuki Sonoda verfasserin aut Masahiro Adachi verfasserin aut Isao Ichino verfasserin aut Yuko Horiuchi verfasserin aut Souichi Uekihara verfasserin aut Shingo Morimitsu verfasserin aut Mitsuhiro Nakazawa verfasserin aut Tadashi Seguchi verfasserin aut Kengo Kaneko verfasserin aut In BMJ Open Diabetes Research & Care BMJ Publishing Group, 2016 9(2021), 1 (DE-627)768094542 (DE-600)2732918-5 20524897 nnns volume:9 year:2021 number:1 https://doi.org/10.1136/bmjdrc-2020-001787 kostenfrei https://doaj.org/article/9dc90dc2c997472e81cb2c1c6cd779d5 kostenfrei https://drc.bmj.com/content/9/1/e001787.full kostenfrei https://doaj.org/toc/2052-4897 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 1
allfieldsGer	10.1136/bmjdrc-2020-001787 doi (DE-627)DOAJ002062054 (DE-599)DOAJ9dc90dc2c997472e81cb2c1c6cd779d5 DE-627 ger DE-627 rakwb eng RC648-665 Masakazu Kobayashi verfasserin aut Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction Given an increasing use of dipeptidyl peptidase-4 (DPP-4) inhibitors to treat patients with type 2 diabetes mellitus in the real-world setting, we conducted a prospective observational study (Japan-based Clinical Research Network for Diabetes Registry: J-BRAND Registry) to elucidate the safety and efficacy profile of long-term usage of alogliptin.Research design and methods We registered 5969 patients from April 2012 through September 2014, who started receiving alogliptin (group A) or other classes of oral hypoglycemic agents (OHAs; group B), and were followed for 3 years at 239 sites nationwide. Safety was the primary outcome. Symptomatic hypoglycemia, pancreatitis, skin disorders of non-extrinsic origin, severe infections, and cancer were collected as major adverse events (AEs). Efficacy assessment was the secondary outcome and included changes in hemoglobin A1c (HbA1c), fasting blood glucose, fasting insulin and urinary albumin.Results Of the registered, 5150 (group A: 3395 and group B: 1755) and 5096 (3358 and 1738) were included for safety and efficacy analysis, respectively. Group A patients mostly (>90%) continued to use alogliptin. In group B, biguanides were the primary agents, while DPP-4 inhibitors were added in up to ~36% of patients. The overall incidence of AEs was similar between the two groups (42.7% vs 42.2%). Kaplan-Meier analysis revealed the incidence of cancer was significantly higher in group A than in group B (7.4% vs 4.8%, p=0.040), while no significant incidence difference was observed in the individual cancer. Multivariate Cox regression analysis revealed that the imbalanced patient distribution (more elderly patients in group A than in group B), but not alogliptin usage per se, contributed to cancer development. The incidence of other major AE categories was with no between-group difference. Between-group difference was not detected, either, in the incidence of microvascular and macrovascular complications. HbA1c and fasting glucose decreased significantly at the 0.5-year visit and nearly plateaued thereafter in both groups.Conclusions Alogliptin as a representative of DPP-4 inhibitors was safe and durably efficacious when used alone or with other OHAs for patients with type 2 diabetes in the real world setting. Diseases of the endocrine glands. Clinical endocrinology Hirohito Sone verfasserin aut Haruhiko Osawa verfasserin aut Daisuke Koya verfasserin aut Takanori Miura verfasserin aut Yoshihito Atsumi verfasserin aut Udai Nakamura verfasserin aut Eiichi Araki verfasserin aut Hitoshi Shimano verfasserin aut Yukio Tanizawa verfasserin aut Jiro Nakamura verfasserin aut Yuichiro Yamada verfasserin aut Nobuya Inagaki verfasserin aut Atsuko Abiko verfasserin aut Hideki Katagiri verfasserin aut Michio Hayashi verfasserin aut Keiko Naruse verfasserin aut Shimpei Fujimoto verfasserin aut Masazumi Fujiwara verfasserin aut Kenichi Shikata verfasserin aut Yosuke Okada verfasserin aut Tsutomu Yamazaki verfasserin aut Sou Nagai verfasserin aut Katsuyuki Yanagisawa verfasserin aut Hiromichi Kijima verfasserin aut Shinji Taneda verfasserin aut Shigeyuki Saitoh verfasserin aut Daisuke Ikeda verfasserin aut Fuminori Hirano verfasserin aut Haruhiko Yoshimura verfasserin aut Mitsutaka Inoue verfasserin aut Masahiko Katoh verfasserin aut Osamu Nakagaki verfasserin aut Chiho Yamamoto verfasserin aut Akitsuki Morikawa verfasserin aut Shin Furukawa verfasserin aut Takeshi Koshiya verfasserin aut Hajime Sugawara verfasserin aut Takumi Uchida verfasserin aut Noe Takakubo verfasserin aut Yasushi Ishigaki verfasserin aut Susumu Suzuki verfasserin aut Takashi Shimotomai verfasserin aut Naoki Tamasawa verfasserin aut Jun Matsui verfasserin aut Takashi Goto verfasserin aut Toshihide Oizumi verfasserin aut Shinji Susa verfasserin aut Makoto Daimon verfasserin aut Hiroshi Murakami verfasserin aut Takashi Sugawara verfasserin aut Hiroaki Akai verfasserin aut Mari Nakamura verfasserin aut Yoshiji Ogawa verfasserin aut Takao Yokoshima verfasserin aut Tsuyoshi Watanabe verfasserin aut Michio Shimabukuro verfasserin aut Kazuhisa Tsukamoto verfasserin aut Motoei Kunimi verfasserin aut Jo Satoh verfasserin aut Atushi Okuyama verfasserin aut Kazutaka Ogawa verfasserin aut Hideyuki Eguchi verfasserin aut Mamoru Kimura verfasserin aut Hiroshi Kouno verfasserin aut Yohei Horikawa verfasserin aut Shin Ikejima verfasserin aut Masaru Saitoh verfasserin aut Naoyoshi Minami verfasserin aut Akihiro Sekikawa verfasserin aut Toyoyoshi Uchida verfasserin aut Toshihide Kawai verfasserin aut Nobuya Fujita verfasserin aut Ken Tomotsune verfasserin aut Shigeo Yamashita verfasserin aut Motoji Naka verfasserin aut Toru Hiyoshi verfasserin aut Tomotaka Katoh verfasserin aut Kumiko Hamano verfasserin aut Kouichi Inukai verfasserin aut Takuma Kondo verfasserin aut Kazuhiro Tsumura verfasserin aut Yoko Matsuzawa verfasserin aut Masahiro Mimura verfasserin aut Masahiko Kawasumi verfasserin aut Izumi Takei verfasserin aut Masafumi Matsuda verfasserin aut Ichiro Tatsuno verfasserin aut Nobuyuki Banba verfasserin aut Akihiko Ando verfasserin aut Masao Toyoda verfasserin aut Daisuke Suzuki verfasserin aut Takahiro Iijima verfasserin aut Yasumichi Mori verfasserin aut Yutaka Uehara verfasserin aut Yoshihiko Satoh verfasserin aut Kazuaki Yahata verfasserin aut Yoshimasa Asoh verfasserin aut Koichiro Kuwabara verfasserin aut Souichi Takizawa verfasserin aut Yasushi Tanaka verfasserin aut Koutaroh Yokote verfasserin aut Masako Tohgo verfasserin aut Takanobu Itoi verfasserin aut Shigeru Miyazaki verfasserin aut Hiroshi Itoh verfasserin aut Teruo Shiba verfasserin aut Takahisa Hirose verfasserin aut Mariko Higa verfasserin aut Masanobu Yamada verfasserin aut Osamu Ogawa verfasserin aut Masatoshi Kuroki verfasserin aut Shinobu Satoh verfasserin aut Makoto Ujihara verfasserin aut Kenjiroh Yamanaka verfasserin aut Hajime Koyano verfasserin aut Tadashi Yamakawa verfasserin aut Kenichiroh Takahashi verfasserin aut Kazuki Orime verfasserin aut Tsutomu Hirano verfasserin aut Jiroh Morimoto verfasserin aut Takashi Itoh verfasserin aut Yuzoh Mizuno verfasserin aut Naoyuki Yamamoto verfasserin aut Han Miyatake verfasserin aut Mina Yamaguchi verfasserin aut Kenji Yamane verfasserin aut Masahiko Kure verfasserin aut Satoko Kawabe verfasserin aut Masahumi Kakei verfasserin aut Masashi Yoshida verfasserin aut Hiroyuki Itoh verfasserin aut Nobuaki Minami verfasserin aut Kazuki Kobayashi verfasserin aut Yusuke Fujino verfasserin aut Makoto Shibuya verfasserin aut Midori Hosokawa verfasserin aut Isao Nozaki verfasserin aut Chigure Nawa verfasserin aut Tamio Ieiri verfasserin aut Takayuki Watanabe verfasserin aut Yoshio Katoh verfasserin aut Takuyuki Katabami verfasserin aut Michiko Handa verfasserin aut Issei Shimada verfasserin aut Kenichi Ohya verfasserin aut Yoshihiro Ogawa verfasserin aut Takanobu Yoshimoto verfasserin aut Jiroh Nakamura verfasserin aut Naotsuka Okayama verfasserin aut Kenro Imaeda verfasserin aut Syuko Yoshioka verfasserin aut Masako Murakami verfasserin aut Takashi Murase verfasserin aut Yoshihiko Yamada verfasserin aut Yutaka Yano verfasserin aut Hiromitsu Sasaki verfasserin aut Yasuhiro Sumida verfasserin aut Osamu Yonaha verfasserin aut Hiroshi Sobajima verfasserin aut Mitsuyasu Ito verfasserin aut Atushi Suzuki verfasserin aut Atsuko Ishikawa verfasserin aut Takehiko Ichikawa verfasserin aut Shogo Asano verfasserin aut Shinobu Goto verfasserin aut Sakuma Hiroya verfasserin aut Hiroshi Murase verfasserin aut Shozo Ogawa verfasserin aut Hideki Okamoto verfasserin aut Kotaro Nagai verfasserin aut Koji Nagayama verfasserin aut Masanori Yoshida verfasserin aut Norio Takahashi verfasserin aut Kazuhisa Takami verfasserin aut Tsuneo Ono verfasserin aut Takanobu Morihiro verfasserin aut Daisuke Tanaka verfasserin aut Noriko Takahara verfasserin aut Satoshi Miyata verfasserin aut Mamiko Tsugawa verfasserin aut Koichiro Yasuda verfasserin aut Seiji Muro verfasserin aut Masanori Emoto verfasserin aut Ikuo Mineo verfasserin aut Ichiro Shiojima verfasserin aut Takeshi Kurose verfasserin aut Makoto Ohashi verfasserin aut Yumiko Kawabata verfasserin aut Mitsushige Nishikawa verfasserin aut Emiko Nomura verfasserin aut Yasuyuki Nishimura verfasserin aut Yasuhiro Ono verfasserin aut Yasuhisa Yamamoto verfasserin aut Keigo Naka verfasserin aut Taizo Yamamoto verfasserin aut Rika Usuda verfasserin aut Hiroshi Akahori verfasserin aut Seika Kato verfasserin aut Hiroyuki Konya verfasserin aut Yutaka Umayahara verfasserin aut Takashi Seta verfasserin aut Hideki Taki verfasserin aut Masashi Sekiya verfasserin aut Shinichi Mogami verfasserin aut Sumie Fujii verfasserin aut Toshiyuki Hibuse verfasserin aut Shingo Tsuji verfasserin aut Hirofumi Sumi verfasserin aut Yasuro Kumeda verfasserin aut Akinori Kogure verfasserin aut Kenji Furukawa verfasserin aut Akira Kuroe verfasserin aut Hideaki Sawaki verfasserin aut Narihiro Hibiki verfasserin aut Yoshihiro Kitagawa verfasserin aut Yukihiro Bando verfasserin aut Akira Ono verfasserin aut Rikako Uenaka verfasserin aut Seitaro Omoto verfasserin aut Yuki Kita verfasserin aut Eiko Ri verfasserin aut Ryutaro Numaguchi verfasserin aut Sachiko Kawashima verfasserin aut Ichiro Kisimoto verfasserin aut Kiminori Hosoda verfasserin aut Yoshihiko Araki verfasserin aut Tetsuroh Arimura verfasserin aut Mitsuru Hashiramoto verfasserin aut Koumei Takeda verfasserin aut Akira Matsutani verfasserin aut Yasushi Inoue verfasserin aut Fumio Sawano verfasserin aut Nozomu Kamei verfasserin aut Yasuo Ito verfasserin aut Miwa Morita verfasserin aut Yoshiaki Oda verfasserin aut Rui Kishimoto verfasserin aut Katsuhiro Hatao verfasserin aut Tomoatsu Mune verfasserin aut Fumiko Kawasaki verfasserin aut Hiroki Teragawa verfasserin aut Ken Yaga verfasserin aut Keita Ishii verfasserin aut Kyouji Hirata verfasserin aut Tatsuaki Nakatou verfasserin aut Yutaka Nitta verfasserin aut Naoki Fujita verfasserin aut Masayasu Yoneda verfasserin aut Masatoshi Tsuru verfasserin aut Shinichirou Ando verfasserin aut Toshiaki Kakiba verfasserin aut Michihiro Toyoshige verfasserin aut Tsuguka Shiwa verfasserin aut Hiroaki Miyaoka verfasserin aut Yasumi Shintani verfasserin aut Takenori Sakai verfasserin aut Tetsuji Niiya verfasserin aut Shinpei Fujimoto verfasserin aut Hisaka Minami verfasserin aut Yoshihiko Noma verfasserin aut Masaaki Tamaru verfasserin aut Yoshitaka Sayou verfasserin aut Tomoyo Oyama verfasserin aut Masamoto Torisu verfasserin aut Yuichi Fujinaka verfasserin aut Yoshitaka Kumon verfasserin aut Shozo Miyauchi verfasserin aut Morikazu Onji verfasserin aut Toru Nakamura verfasserin aut Yousuke Okada verfasserin aut Toshihiko Yanase verfasserin aut Kenro Nishida verfasserin aut Syuji Nakamura verfasserin aut Kunihisa Kobayashi verfasserin aut Nobuhiko Wada verfasserin aut Moritake Higa verfasserin aut Koji Matsushita verfasserin aut Yoshihiko Nishio verfasserin aut Ryoji Fujimoto verfasserin aut Yasuyuki Kihara verfasserin aut Shinichiro Mine verfasserin aut Tadashi Arao verfasserin aut Hiromi Tasaki verfasserin aut Yasuto Matsuo verfasserin aut Hirofumi Matsuda verfasserin aut Kohei Uriu verfasserin aut Kazuko Kanda verfasserin aut Kazuo Ibaraki verfasserin aut Yoshio Kaku verfasserin aut Yasuhiro Takaki verfasserin aut Iwaho Hazekawa verfasserin aut Kenji Ebihara verfasserin aut Eiichiro Watanabe verfasserin aut Iku Sakurada verfasserin aut Kazuhisa Muraishi verfasserin aut Tamami Oshige verfasserin aut Junichi Yasuda verfasserin aut Toyoshi Iguchi verfasserin aut Noriyuki Sonoda verfasserin aut Masahiro Adachi verfasserin aut Isao Ichino verfasserin aut Yuko Horiuchi verfasserin aut Souichi Uekihara verfasserin aut Shingo Morimitsu verfasserin aut Mitsuhiro Nakazawa verfasserin aut Tadashi Seguchi verfasserin aut Kengo Kaneko verfasserin aut In BMJ Open Diabetes Research & Care BMJ Publishing Group, 2016 9(2021), 1 (DE-627)768094542 (DE-600)2732918-5 20524897 nnns volume:9 year:2021 number:1 https://doi.org/10.1136/bmjdrc-2020-001787 kostenfrei https://doaj.org/article/9dc90dc2c997472e81cb2c1c6cd779d5 kostenfrei https://drc.bmj.com/content/9/1/e001787.full kostenfrei https://doaj.org/toc/2052-4897 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 1
allfieldsSound	10.1136/bmjdrc-2020-001787 doi (DE-627)DOAJ002062054 (DE-599)DOAJ9dc90dc2c997472e81cb2c1c6cd779d5 DE-627 ger DE-627 rakwb eng RC648-665 Masakazu Kobayashi verfasserin aut Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction Given an increasing use of dipeptidyl peptidase-4 (DPP-4) inhibitors to treat patients with type 2 diabetes mellitus in the real-world setting, we conducted a prospective observational study (Japan-based Clinical Research Network for Diabetes Registry: J-BRAND Registry) to elucidate the safety and efficacy profile of long-term usage of alogliptin.Research design and methods We registered 5969 patients from April 2012 through September 2014, who started receiving alogliptin (group A) or other classes of oral hypoglycemic agents (OHAs; group B), and were followed for 3 years at 239 sites nationwide. Safety was the primary outcome. Symptomatic hypoglycemia, pancreatitis, skin disorders of non-extrinsic origin, severe infections, and cancer were collected as major adverse events (AEs). Efficacy assessment was the secondary outcome and included changes in hemoglobin A1c (HbA1c), fasting blood glucose, fasting insulin and urinary albumin.Results Of the registered, 5150 (group A: 3395 and group B: 1755) and 5096 (3358 and 1738) were included for safety and efficacy analysis, respectively. Group A patients mostly (>90%) continued to use alogliptin. In group B, biguanides were the primary agents, while DPP-4 inhibitors were added in up to ~36% of patients. The overall incidence of AEs was similar between the two groups (42.7% vs 42.2%). Kaplan-Meier analysis revealed the incidence of cancer was significantly higher in group A than in group B (7.4% vs 4.8%, p=0.040), while no significant incidence difference was observed in the individual cancer. Multivariate Cox regression analysis revealed that the imbalanced patient distribution (more elderly patients in group A than in group B), but not alogliptin usage per se, contributed to cancer development. The incidence of other major AE categories was with no between-group difference. Between-group difference was not detected, either, in the incidence of microvascular and macrovascular complications. HbA1c and fasting glucose decreased significantly at the 0.5-year visit and nearly plateaued thereafter in both groups.Conclusions Alogliptin as a representative of DPP-4 inhibitors was safe and durably efficacious when used alone or with other OHAs for patients with type 2 diabetes in the real world setting. Diseases of the endocrine glands. Clinical endocrinology Hirohito Sone verfasserin aut Haruhiko Osawa verfasserin aut Daisuke Koya verfasserin aut Takanori Miura verfasserin aut Yoshihito Atsumi verfasserin aut Udai Nakamura verfasserin aut Eiichi Araki verfasserin aut Hitoshi Shimano verfasserin aut Yukio Tanizawa verfasserin aut Jiro Nakamura verfasserin aut Yuichiro Yamada verfasserin aut Nobuya Inagaki verfasserin aut Atsuko Abiko verfasserin aut Hideki Katagiri verfasserin aut Michio Hayashi verfasserin aut Keiko Naruse verfasserin aut Shimpei Fujimoto verfasserin aut Masazumi Fujiwara verfasserin aut Kenichi Shikata verfasserin aut Yosuke Okada verfasserin aut Tsutomu Yamazaki verfasserin aut Sou Nagai verfasserin aut Katsuyuki Yanagisawa verfasserin aut Hiromichi Kijima verfasserin aut Shinji Taneda verfasserin aut Shigeyuki Saitoh verfasserin aut Daisuke Ikeda verfasserin aut Fuminori Hirano verfasserin aut Haruhiko Yoshimura verfasserin aut Mitsutaka Inoue verfasserin aut Masahiko Katoh verfasserin aut Osamu Nakagaki verfasserin aut Chiho Yamamoto verfasserin aut Akitsuki Morikawa verfasserin aut Shin Furukawa verfasserin aut Takeshi Koshiya verfasserin aut Hajime Sugawara verfasserin aut Takumi Uchida verfasserin aut Noe Takakubo verfasserin aut Yasushi Ishigaki verfasserin aut Susumu Suzuki verfasserin aut Takashi Shimotomai verfasserin aut Naoki Tamasawa verfasserin aut Jun Matsui verfasserin aut Takashi Goto verfasserin aut Toshihide Oizumi verfasserin aut Shinji Susa verfasserin aut Makoto Daimon verfasserin aut Hiroshi Murakami verfasserin aut Takashi Sugawara verfasserin aut Hiroaki Akai verfasserin aut Mari Nakamura verfasserin aut Yoshiji Ogawa verfasserin aut Takao Yokoshima verfasserin aut Tsuyoshi Watanabe verfasserin aut Michio Shimabukuro verfasserin aut Kazuhisa Tsukamoto verfasserin aut Motoei Kunimi verfasserin aut Jo Satoh verfasserin aut Atushi Okuyama verfasserin aut Kazutaka Ogawa verfasserin aut Hideyuki Eguchi verfasserin aut Mamoru Kimura verfasserin aut Hiroshi Kouno verfasserin aut Yohei Horikawa verfasserin aut Shin Ikejima verfasserin aut Masaru Saitoh verfasserin aut Naoyoshi Minami verfasserin aut Akihiro Sekikawa verfasserin aut Toyoyoshi Uchida verfasserin aut Toshihide Kawai verfasserin aut Nobuya Fujita verfasserin aut Ken Tomotsune verfasserin aut Shigeo Yamashita verfasserin aut Motoji Naka verfasserin aut Toru Hiyoshi verfasserin aut Tomotaka Katoh verfasserin aut Kumiko Hamano verfasserin aut Kouichi Inukai verfasserin aut Takuma Kondo verfasserin aut Kazuhiro Tsumura verfasserin aut Yoko Matsuzawa verfasserin aut Masahiro Mimura verfasserin aut Masahiko Kawasumi verfasserin aut Izumi Takei verfasserin aut Masafumi Matsuda verfasserin aut Ichiro Tatsuno verfasserin aut Nobuyuki Banba verfasserin aut Akihiko Ando verfasserin aut Masao Toyoda verfasserin aut Daisuke Suzuki verfasserin aut Takahiro Iijima verfasserin aut Yasumichi Mori verfasserin aut Yutaka Uehara verfasserin aut Yoshihiko Satoh verfasserin aut Kazuaki Yahata verfasserin aut Yoshimasa Asoh verfasserin aut Koichiro Kuwabara verfasserin aut Souichi Takizawa verfasserin aut Yasushi Tanaka verfasserin aut Koutaroh Yokote verfasserin aut Masako Tohgo verfasserin aut Takanobu Itoi verfasserin aut Shigeru Miyazaki verfasserin aut Hiroshi Itoh verfasserin aut Teruo Shiba verfasserin aut Takahisa Hirose verfasserin aut Mariko Higa verfasserin aut Masanobu Yamada verfasserin aut Osamu Ogawa verfasserin aut Masatoshi Kuroki verfasserin aut Shinobu Satoh verfasserin aut Makoto Ujihara verfasserin aut Kenjiroh Yamanaka verfasserin aut Hajime Koyano verfasserin aut Tadashi Yamakawa verfasserin aut Kenichiroh Takahashi verfasserin aut Kazuki Orime verfasserin aut Tsutomu Hirano verfasserin aut Jiroh Morimoto verfasserin aut Takashi Itoh verfasserin aut Yuzoh Mizuno verfasserin aut Naoyuki Yamamoto verfasserin aut Han Miyatake verfasserin aut Mina Yamaguchi verfasserin aut Kenji Yamane verfasserin aut Masahiko Kure verfasserin aut Satoko Kawabe verfasserin aut Masahumi Kakei verfasserin aut Masashi Yoshida verfasserin aut Hiroyuki Itoh verfasserin aut Nobuaki Minami verfasserin aut Kazuki Kobayashi verfasserin aut Yusuke Fujino verfasserin aut Makoto Shibuya verfasserin aut Midori Hosokawa verfasserin aut Isao Nozaki verfasserin aut Chigure Nawa verfasserin aut Tamio Ieiri verfasserin aut Takayuki Watanabe verfasserin aut Yoshio Katoh verfasserin aut Takuyuki Katabami verfasserin aut Michiko Handa verfasserin aut Issei Shimada verfasserin aut Kenichi Ohya verfasserin aut Yoshihiro Ogawa verfasserin aut Takanobu Yoshimoto verfasserin aut Jiroh Nakamura verfasserin aut Naotsuka Okayama verfasserin aut Kenro Imaeda verfasserin aut Syuko Yoshioka verfasserin aut Masako Murakami verfasserin aut Takashi Murase verfasserin aut Yoshihiko Yamada verfasserin aut Yutaka Yano verfasserin aut Hiromitsu Sasaki verfasserin aut Yasuhiro Sumida verfasserin aut Osamu Yonaha verfasserin aut Hiroshi Sobajima verfasserin aut Mitsuyasu Ito verfasserin aut Atushi Suzuki verfasserin aut Atsuko Ishikawa verfasserin aut Takehiko Ichikawa verfasserin aut Shogo Asano verfasserin aut Shinobu Goto verfasserin aut Sakuma Hiroya verfasserin aut Hiroshi Murase verfasserin aut Shozo Ogawa verfasserin aut Hideki Okamoto verfasserin aut Kotaro Nagai verfasserin aut Koji Nagayama verfasserin aut Masanori Yoshida verfasserin aut Norio Takahashi verfasserin aut Kazuhisa Takami verfasserin aut Tsuneo Ono verfasserin aut Takanobu Morihiro verfasserin aut Daisuke Tanaka verfasserin aut Noriko Takahara verfasserin aut Satoshi Miyata verfasserin aut Mamiko Tsugawa verfasserin aut Koichiro Yasuda verfasserin aut Seiji Muro verfasserin aut Masanori Emoto verfasserin aut Ikuo Mineo verfasserin aut Ichiro Shiojima verfasserin aut Takeshi Kurose verfasserin aut Makoto Ohashi verfasserin aut Yumiko Kawabata verfasserin aut Mitsushige Nishikawa verfasserin aut Emiko Nomura verfasserin aut Yasuyuki Nishimura verfasserin aut Yasuhiro Ono verfasserin aut Yasuhisa Yamamoto verfasserin aut Keigo Naka verfasserin aut Taizo Yamamoto verfasserin aut Rika Usuda verfasserin aut Hiroshi Akahori verfasserin aut Seika Kato verfasserin aut Hiroyuki Konya verfasserin aut Yutaka Umayahara verfasserin aut Takashi Seta verfasserin aut Hideki Taki verfasserin aut Masashi Sekiya verfasserin aut Shinichi Mogami verfasserin aut Sumie Fujii verfasserin aut Toshiyuki Hibuse verfasserin aut Shingo Tsuji verfasserin aut Hirofumi Sumi verfasserin aut Yasuro Kumeda verfasserin aut Akinori Kogure verfasserin aut Kenji Furukawa verfasserin aut Akira Kuroe verfasserin aut Hideaki Sawaki verfasserin aut Narihiro Hibiki verfasserin aut Yoshihiro Kitagawa verfasserin aut Yukihiro Bando verfasserin aut Akira Ono verfasserin aut Rikako Uenaka verfasserin aut Seitaro Omoto verfasserin aut Yuki Kita verfasserin aut Eiko Ri verfasserin aut Ryutaro Numaguchi verfasserin aut Sachiko Kawashima verfasserin aut Ichiro Kisimoto verfasserin aut Kiminori Hosoda verfasserin aut Yoshihiko Araki verfasserin aut Tetsuroh Arimura verfasserin aut Mitsuru Hashiramoto verfasserin aut Koumei Takeda verfasserin aut Akira Matsutani verfasserin aut Yasushi Inoue verfasserin aut Fumio Sawano verfasserin aut Nozomu Kamei verfasserin aut Yasuo Ito verfasserin aut Miwa Morita verfasserin aut Yoshiaki Oda verfasserin aut Rui Kishimoto verfasserin aut Katsuhiro Hatao verfasserin aut Tomoatsu Mune verfasserin aut Fumiko Kawasaki verfasserin aut Hiroki Teragawa verfasserin aut Ken Yaga verfasserin aut Keita Ishii verfasserin aut Kyouji Hirata verfasserin aut Tatsuaki Nakatou verfasserin aut Yutaka Nitta verfasserin aut Naoki Fujita verfasserin aut Masayasu Yoneda verfasserin aut Masatoshi Tsuru verfasserin aut Shinichirou Ando verfasserin aut Toshiaki Kakiba verfasserin aut Michihiro Toyoshige verfasserin aut Tsuguka Shiwa verfasserin aut Hiroaki Miyaoka verfasserin aut Yasumi Shintani verfasserin aut Takenori Sakai verfasserin aut Tetsuji Niiya verfasserin aut Shinpei Fujimoto verfasserin aut Hisaka Minami verfasserin aut Yoshihiko Noma verfasserin aut Masaaki Tamaru verfasserin aut Yoshitaka Sayou verfasserin aut Tomoyo Oyama verfasserin aut Masamoto Torisu verfasserin aut Yuichi Fujinaka verfasserin aut Yoshitaka Kumon verfasserin aut Shozo Miyauchi verfasserin aut Morikazu Onji verfasserin aut Toru Nakamura verfasserin aut Yousuke Okada verfasserin aut Toshihiko Yanase verfasserin aut Kenro Nishida verfasserin aut Syuji Nakamura verfasserin aut Kunihisa Kobayashi verfasserin aut Nobuhiko Wada verfasserin aut Moritake Higa verfasserin aut Koji Matsushita verfasserin aut Yoshihiko Nishio verfasserin aut Ryoji Fujimoto verfasserin aut Yasuyuki Kihara verfasserin aut Shinichiro Mine verfasserin aut Tadashi Arao verfasserin aut Hiromi Tasaki verfasserin aut Yasuto Matsuo verfasserin aut Hirofumi Matsuda verfasserin aut Kohei Uriu verfasserin aut Kazuko Kanda verfasserin aut Kazuo Ibaraki verfasserin aut Yoshio Kaku verfasserin aut Yasuhiro Takaki verfasserin aut Iwaho Hazekawa verfasserin aut Kenji Ebihara verfasserin aut Eiichiro Watanabe verfasserin aut Iku Sakurada verfasserin aut Kazuhisa Muraishi verfasserin aut Tamami Oshige verfasserin aut Junichi Yasuda verfasserin aut Toyoshi Iguchi verfasserin aut Noriyuki Sonoda verfasserin aut Masahiro Adachi verfasserin aut Isao Ichino verfasserin aut Yuko Horiuchi verfasserin aut Souichi Uekihara verfasserin aut Shingo Morimitsu verfasserin aut Mitsuhiro Nakazawa verfasserin aut Tadashi Seguchi verfasserin aut Kengo Kaneko verfasserin aut In BMJ Open Diabetes Research & Care BMJ Publishing Group, 2016 9(2021), 1 (DE-627)768094542 (DE-600)2732918-5 20524897 nnns volume:9 year:2021 number:1 https://doi.org/10.1136/bmjdrc-2020-001787 kostenfrei https://doaj.org/article/9dc90dc2c997472e81cb2c1c6cd779d5 kostenfrei https://drc.bmj.com/content/9/1/e001787.full kostenfrei https://doaj.org/toc/2052-4897 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 1
language	English
source	In BMJ Open Diabetes Research & Care 9(2021), 1 volume:9 year:2021 number:1
sourceStr	In BMJ Open Diabetes Research & Care 9(2021), 1 volume:9 year:2021 number:1
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Diseases of the endocrine glands. Clinical endocrinology
isfreeaccess_bool	true
container_title	BMJ Open Diabetes Research & Care
authorswithroles_txt_mv	Masakazu Kobayashi @@aut@@ Hirohito Sone @@aut@@ Haruhiko Osawa @@aut@@ Daisuke Koya @@aut@@ Takanori Miura @@aut@@ Yoshihito Atsumi @@aut@@ Udai Nakamura @@aut@@ Eiichi Araki @@aut@@ Hitoshi Shimano @@aut@@ Yukio Tanizawa @@aut@@ Jiro Nakamura @@aut@@ Yuichiro Yamada @@aut@@ Nobuya Inagaki @@aut@@ Atsuko Abiko @@aut@@ Hideki Katagiri @@aut@@ Michio Hayashi @@aut@@ Keiko Naruse @@aut@@ Shimpei Fujimoto @@aut@@ Masazumi Fujiwara @@aut@@ Kenichi Shikata @@aut@@ Yosuke Okada @@aut@@ Tsutomu Yamazaki @@aut@@ Sou Nagai @@aut@@ Katsuyuki Yanagisawa @@aut@@ Hiromichi Kijima @@aut@@ Shinji Taneda @@aut@@ Shigeyuki Saitoh @@aut@@ Daisuke Ikeda @@aut@@ Fuminori Hirano @@aut@@ Haruhiko Yoshimura @@aut@@ Mitsutaka Inoue @@aut@@ Masahiko Katoh @@aut@@ Osamu Nakagaki @@aut@@ Chiho Yamamoto @@aut@@ Akitsuki Morikawa @@aut@@ Shin Furukawa @@aut@@ Takeshi Koshiya @@aut@@ Hajime Sugawara @@aut@@ Takumi Uchida @@aut@@ Noe Takakubo @@aut@@ Yasushi Ishigaki @@aut@@ Susumu Suzuki @@aut@@ Takashi Shimotomai @@aut@@ Naoki Tamasawa @@aut@@ Jun Matsui @@aut@@ Takashi Goto @@aut@@ Toshihide Oizumi @@aut@@ Shinji Susa @@aut@@ Makoto Daimon @@aut@@ Hiroshi Murakami @@aut@@ Takashi Sugawara @@aut@@ Hiroaki Akai @@aut@@ Mari Nakamura @@aut@@ Yoshiji Ogawa @@aut@@ Takao Yokoshima @@aut@@ Tsuyoshi Watanabe @@aut@@ Michio Shimabukuro @@aut@@ Kazuhisa Tsukamoto @@aut@@ Motoei Kunimi @@aut@@ Jo Satoh @@aut@@ Atushi Okuyama @@aut@@ Kazutaka Ogawa @@aut@@ Hideyuki Eguchi @@aut@@ Mamoru Kimura @@aut@@ Hiroshi Kouno @@aut@@ Yohei Horikawa @@aut@@ Shin Ikejima @@aut@@ Masaru Saitoh @@aut@@ Naoyoshi Minami @@aut@@ Akihiro Sekikawa @@aut@@ Toyoyoshi Uchida @@aut@@ Toshihide Kawai @@aut@@ Nobuya Fujita @@aut@@ Ken Tomotsune @@aut@@ Shigeo Yamashita @@aut@@ Motoji Naka @@aut@@ Toru Hiyoshi @@aut@@ Tomotaka Katoh @@aut@@ Kumiko Hamano @@aut@@ Kouichi Inukai @@aut@@ Takuma Kondo @@aut@@ Kazuhiro Tsumura @@aut@@ Yoko Matsuzawa @@aut@@ Masahiro Mimura @@aut@@ Masahiko Kawasumi @@aut@@ Izumi Takei @@aut@@ Masafumi Matsuda @@aut@@ Ichiro Tatsuno @@aut@@ Nobuyuki Banba @@aut@@ Akihiko Ando @@aut@@ Masao Toyoda @@aut@@ Daisuke Suzuki @@aut@@ Takahiro Iijima @@aut@@ Yasumichi Mori @@aut@@ Yutaka Uehara @@aut@@ Yoshihiko Satoh @@aut@@ Kazuaki Yahata @@aut@@ Yoshimasa Asoh @@aut@@ Koichiro Kuwabara @@aut@@ Souichi Takizawa @@aut@@ Yasushi Tanaka @@aut@@ Koutaroh Yokote @@aut@@ Masako Tohgo @@aut@@ Takanobu Itoi @@aut@@ Shigeru Miyazaki @@aut@@ Hiroshi Itoh @@aut@@ Teruo Shiba @@aut@@ Takahisa Hirose @@aut@@ Mariko Higa @@aut@@ Masanobu Yamada @@aut@@ Osamu Ogawa @@aut@@ Masatoshi Kuroki @@aut@@ Shinobu Satoh @@aut@@ Makoto Ujihara @@aut@@ Kenjiroh Yamanaka @@aut@@ Hajime Koyano @@aut@@ Tadashi Yamakawa @@aut@@ Kenichiroh Takahashi @@aut@@ Kazuki Orime @@aut@@ Tsutomu Hirano @@aut@@ Jiroh Morimoto @@aut@@ Takashi Itoh @@aut@@ Yuzoh Mizuno @@aut@@ Naoyuki Yamamoto @@aut@@ Han Miyatake @@aut@@ Mina Yamaguchi @@aut@@ Kenji Yamane @@aut@@ Masahiko Kure @@aut@@ Satoko Kawabe @@aut@@ Masahumi Kakei @@aut@@ Masashi Yoshida @@aut@@ Hiroyuki Itoh @@aut@@ Nobuaki Minami @@aut@@ Kazuki Kobayashi @@aut@@ Yusuke Fujino @@aut@@ Makoto Shibuya @@aut@@ Midori Hosokawa @@aut@@ Isao Nozaki @@aut@@ Chigure Nawa @@aut@@ Tamio Ieiri @@aut@@ Takayuki Watanabe @@aut@@ Yoshio Katoh @@aut@@ Takuyuki Katabami @@aut@@ Michiko Handa @@aut@@ Issei Shimada @@aut@@ Kenichi Ohya @@aut@@ Yoshihiro Ogawa @@aut@@ Takanobu Yoshimoto @@aut@@ Jiroh Nakamura @@aut@@ Naotsuka Okayama @@aut@@ Kenro Imaeda @@aut@@ Syuko Yoshioka @@aut@@ Masako Murakami @@aut@@ Takashi Murase @@aut@@ Yoshihiko Yamada @@aut@@ Yutaka Yano @@aut@@ Hiromitsu Sasaki @@aut@@ Yasuhiro Sumida @@aut@@ Osamu Yonaha @@aut@@ Hiroshi Sobajima @@aut@@ Mitsuyasu Ito @@aut@@ Atushi Suzuki @@aut@@ Atsuko Ishikawa @@aut@@ Takehiko Ichikawa @@aut@@ Shogo Asano @@aut@@ Shinobu Goto @@aut@@ Sakuma Hiroya @@aut@@ Hiroshi Murase @@aut@@ Shozo Ogawa @@aut@@ Hideki Okamoto @@aut@@ Kotaro Nagai @@aut@@ Koji Nagayama @@aut@@ Masanori Yoshida @@aut@@ Norio Takahashi @@aut@@ Kazuhisa Takami @@aut@@ Tsuneo Ono @@aut@@ Takanobu Morihiro @@aut@@ Daisuke Tanaka @@aut@@ Noriko Takahara @@aut@@ Satoshi Miyata @@aut@@ Mamiko Tsugawa @@aut@@ Koichiro Yasuda @@aut@@ Seiji Muro @@aut@@ Masanori Emoto @@aut@@ Ikuo Mineo @@aut@@ Ichiro Shiojima @@aut@@ Takeshi Kurose @@aut@@ Makoto Ohashi @@aut@@ Yumiko Kawabata @@aut@@ Mitsushige Nishikawa @@aut@@ Emiko Nomura @@aut@@ Yasuyuki Nishimura @@aut@@ Yasuhiro Ono @@aut@@ Yasuhisa Yamamoto @@aut@@ Keigo Naka @@aut@@ Taizo Yamamoto @@aut@@ Rika Usuda @@aut@@ Hiroshi Akahori @@aut@@ Seika Kato @@aut@@ Hiroyuki Konya @@aut@@ Yutaka Umayahara @@aut@@ Takashi Seta @@aut@@ Hideki Taki @@aut@@ Masashi Sekiya @@aut@@ Shinichi Mogami @@aut@@ Sumie Fujii @@aut@@ Toshiyuki Hibuse @@aut@@ Shingo Tsuji @@aut@@ Hirofumi Sumi @@aut@@ Yasuro Kumeda @@aut@@ Akinori Kogure @@aut@@ Kenji Furukawa @@aut@@ Akira Kuroe @@aut@@ Hideaki Sawaki @@aut@@ Narihiro Hibiki @@aut@@ Yoshihiro Kitagawa @@aut@@ Yukihiro Bando @@aut@@ Akira Ono @@aut@@ Rikako Uenaka @@aut@@ Seitaro Omoto @@aut@@ Yuki Kita @@aut@@ Eiko Ri @@aut@@ Ryutaro Numaguchi @@aut@@ Sachiko Kawashima @@aut@@ Ichiro Kisimoto @@aut@@ Kiminori Hosoda @@aut@@ Yoshihiko Araki @@aut@@ Tetsuroh Arimura @@aut@@ Mitsuru Hashiramoto @@aut@@ Koumei Takeda @@aut@@ Akira Matsutani @@aut@@ Yasushi Inoue @@aut@@ Fumio Sawano @@aut@@ Nozomu Kamei @@aut@@ Yasuo Ito @@aut@@ Miwa Morita @@aut@@ Yoshiaki Oda @@aut@@ Rui Kishimoto @@aut@@ Katsuhiro Hatao @@aut@@ Tomoatsu Mune @@aut@@ Fumiko Kawasaki @@aut@@ Hiroki Teragawa @@aut@@ Ken Yaga @@aut@@ Keita Ishii @@aut@@ Kyouji Hirata @@aut@@ Tatsuaki Nakatou @@aut@@ Yutaka Nitta @@aut@@ Naoki Fujita @@aut@@ Masayasu Yoneda @@aut@@ Masatoshi Tsuru @@aut@@ Shinichirou Ando @@aut@@ Toshiaki Kakiba @@aut@@ Michihiro Toyoshige @@aut@@ Tsuguka Shiwa @@aut@@ Hiroaki Miyaoka @@aut@@ Yasumi Shintani @@aut@@ Takenori Sakai @@aut@@ Tetsuji Niiya @@aut@@ Shinpei Fujimoto @@aut@@ Hisaka Minami @@aut@@ Yoshihiko Noma @@aut@@ Masaaki Tamaru @@aut@@ Yoshitaka Sayou @@aut@@ Tomoyo Oyama @@aut@@ Masamoto Torisu @@aut@@ Yuichi Fujinaka @@aut@@ Yoshitaka Kumon @@aut@@ Shozo Miyauchi @@aut@@ Morikazu Onji @@aut@@ Toru Nakamura @@aut@@ Yousuke Okada @@aut@@ Toshihiko Yanase @@aut@@ Kenro Nishida @@aut@@ Syuji Nakamura @@aut@@ Kunihisa Kobayashi @@aut@@ Nobuhiko Wada @@aut@@ Moritake Higa @@aut@@ Koji Matsushita @@aut@@ Yoshihiko Nishio @@aut@@ Ryoji Fujimoto @@aut@@ Yasuyuki Kihara @@aut@@ Shinichiro Mine @@aut@@ Tadashi Arao @@aut@@ Hiromi Tasaki @@aut@@ Yasuto Matsuo @@aut@@ Hirofumi Matsuda @@aut@@ Kohei Uriu @@aut@@ Kazuko Kanda @@aut@@ Kazuo Ibaraki @@aut@@ Yoshio Kaku @@aut@@ Yasuhiro Takaki @@aut@@ Iwaho Hazekawa @@aut@@ Kenji Ebihara @@aut@@ Eiichiro Watanabe @@aut@@ Iku Sakurada @@aut@@ Kazuhisa Muraishi @@aut@@ Tamami Oshige @@aut@@ Junichi Yasuda @@aut@@ Toyoshi Iguchi @@aut@@ Noriyuki Sonoda @@aut@@ Masahiro Adachi @@aut@@ Isao Ichino @@aut@@ Yuko Horiuchi @@aut@@ Souichi Uekihara @@aut@@ Shingo Morimitsu @@aut@@ Mitsuhiro Nakazawa @@aut@@ Tadashi Seguchi @@aut@@ Kengo Kaneko @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	768094542
id	DOAJ002062054
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ002062054</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309165407.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1136/bmjdrc-2020-001787</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ002062054</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ9dc90dc2c997472e81cb2c1c6cd779d5</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC648-665</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Masakazu Kobayashi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction Given an increasing use of dipeptidyl peptidase-4 (DPP-4) inhibitors to treat patients with type 2 diabetes mellitus in the real-world setting, we conducted a prospective observational study (Japan-based Clinical Research Network for Diabetes Registry: J-BRAND Registry) to elucidate the safety and efficacy profile of long-term usage of alogliptin.Research design and methods We registered 5969 patients from April 2012 through September 2014, who started receiving alogliptin (group A) or other classes of oral hypoglycemic agents (OHAs; group B), and were followed for 3 years at 239 sites nationwide. Safety was the primary outcome. Symptomatic hypoglycemia, pancreatitis, skin disorders of non-extrinsic origin, severe infections, and cancer were collected as major adverse events (AEs). Efficacy assessment was the secondary outcome and included changes in hemoglobin A1c (HbA1c), fasting blood glucose, fasting insulin and urinary albumin.Results Of the registered, 5150 (group A: 3395 and group B: 1755) and 5096 (3358 and 1738) were included for safety and efficacy analysis, respectively. Group A patients mostly (&gt;90%) continued to use alogliptin. In group B, biguanides were the primary agents, while DPP-4 inhibitors were added in up to ~36% of patients. The overall incidence of AEs was similar between the two groups (42.7% vs 42.2%). Kaplan-Meier analysis revealed the incidence of cancer was significantly higher in group A than in group B (7.4% vs 4.8%, p=0.040), while no significant incidence difference was observed in the individual cancer. Multivariate Cox regression analysis revealed that the imbalanced patient distribution (more elderly patients in group A than in group B), but not alogliptin usage per se, contributed to cancer development. The incidence of other major AE categories was with no between-group difference. Between-group difference was not detected, either, in the incidence of microvascular and macrovascular complications. HbA1c and fasting glucose decreased significantly at the 0.5-year visit and nearly plateaued thereafter in both groups.Conclusions Alogliptin as a representative of DPP-4 inhibitors was safe and durably efficacious when used alone or with other OHAs for patients with type 2 diabetes in the real world setting.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the endocrine glands. Clinical endocrinology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hirohito Sone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Haruhiko Osawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daisuke Koya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takanori Miura</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yoshihito Atsumi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Udai Nakamura</subfield><subfield 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Inagaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Atsuko Abiko</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hideki Katagiri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michio Hayashi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Keiko Naruse</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shimpei Fujimoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masazumi Fujiwara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenichi Shikata</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yosuke Okada</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tsutomu Yamazaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sou Nagai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katsuyuki Yanagisawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiromichi Kijima</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shinji Taneda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shigeyuki Saitoh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daisuke Ikeda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fuminori Hirano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Haruhiko Yoshimura</subfield><subfield code="e">verfasserin</subfield><subfield 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Suzuki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takashi Shimotomai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Naoki Tamasawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jun Matsui</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takashi Goto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Toshihide Oizumi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield 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code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Toshihide Kawai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nobuya Fujita</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ken Tomotsune</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shigeo Yamashita</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Motoji Naka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Toru 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code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yasushi Tanaka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Koutaroh Yokote</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masako Tohgo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takanobu Itoi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shigeru Miyazaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiroshi Itoh</subfield><subfield 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Kuroki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shinobu Satoh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Makoto Ujihara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenjiroh Yamanaka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hajime Koyano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tadashi Yamakawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenichiroh Takahashi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kazuki Orime</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tsutomu Hirano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jiroh Morimoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takashi Itoh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yuzoh Mizuno</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Naoyuki Yamamoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Han Miyatake</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mina Yamaguchi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenji Yamane</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masahiko Kure</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Satoko Kawabe</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masahumi Kakei</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masashi Yoshida</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiroyuki Itoh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nobuaki Minami</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kazuki Kobayashi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yusuke Fujino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Makoto Shibuya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Midori Hosokawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Isao Nozaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chigure Nawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tamio Ieiri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takayuki Watanabe</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yoshio Katoh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takuyuki Katabami</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michiko Handa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Issei Shimada</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenichi Ohya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yoshihiro Ogawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takanobu Yoshimoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jiroh Nakamura</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Naotsuka Okayama</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenro Imaeda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Syuko Yoshioka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masako Murakami</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takashi Murase</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yoshihiko Yamada</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yutaka Yano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiromitsu Sasaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yasuhiro Sumida</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Osamu Yonaha</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiroshi Sobajima</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mitsuyasu Ito</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Atushi Suzuki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Atsuko Ishikawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takehiko Ichikawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shogo Asano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shinobu Goto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sakuma Hiroya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiroshi Murase</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shozo Ogawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hideki Okamoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kotaro Nagai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Koji Nagayama</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masanori Yoshida</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Norio Takahashi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kazuhisa Takami</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tsuneo Ono</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takanobu Morihiro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daisuke Tanaka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Noriko Takahara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Satoshi Miyata</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mamiko Tsugawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Koichiro Yasuda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Seiji Muro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masanori Emoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ikuo Mineo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ichiro Shiojima</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takeshi Kurose</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Makoto Ohashi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yumiko Kawabata</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mitsushige Nishikawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emiko Nomura</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yasuyuki Nishimura</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yasuhiro Ono</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yasuhisa Yamamoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Keigo Naka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Taizo Yamamoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rika Usuda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiroshi Akahori</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Seika Kato</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiroyuki Konya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yutaka Umayahara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takashi Seta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hideki Taki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masashi Sekiya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shinichi Mogami</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sumie Fujii</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Toshiyuki Hibuse</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shingo Tsuji</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hirofumi Sumi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yasuro Kumeda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Akinori Kogure</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenji Furukawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Akira Kuroe</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hideaki Sawaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Narihiro Hibiki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yoshihiro Kitagawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yukihiro Bando</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Akira Ono</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rikako Uenaka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Seitaro Omoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yuki Kita</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eiko Ri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ryutaro 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callnumber-first	R - Medicine
author	Masakazu Kobayashi
spellingShingle	Masakazu Kobayashi misc RC648-665 misc Diseases of the endocrine glands. Clinical endocrinology Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry)
authorStr	Masakazu Kobayashi
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author_role	aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut
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callnumber-label	RC648-665
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issn	20524897
topic_title	RC648-665 Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry)
topic	misc RC648-665 misc Diseases of the endocrine glands. Clinical endocrinology
topic_unstemmed	misc RC648-665 misc Diseases of the endocrine glands. Clinical endocrinology
topic_browse	misc RC648-665 misc Diseases of the endocrine glands. Clinical endocrinology
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title	Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry)
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title_full	Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry)
author_sort	Masakazu Kobayashi
journal	BMJ Open Diabetes Research & Care
journalStr	BMJ Open Diabetes Research & Care
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author_browse	Masakazu Kobayashi Hirohito Sone Haruhiko Osawa Daisuke Koya Takanori Miura Yoshihito Atsumi Udai Nakamura Eiichi Araki Hitoshi Shimano Yukio Tanizawa Jiro Nakamura Yuichiro Yamada Nobuya Inagaki Atsuko Abiko Hideki Katagiri Michio Hayashi Keiko Naruse Shimpei Fujimoto Masazumi Fujiwara Kenichi Shikata Yosuke Okada Tsutomu Yamazaki Sou Nagai Katsuyuki Yanagisawa Hiromichi Kijima Shinji Taneda Shigeyuki Saitoh Daisuke Ikeda Fuminori Hirano Haruhiko Yoshimura Mitsutaka Inoue Masahiko Katoh Osamu Nakagaki Chiho Yamamoto Akitsuki Morikawa Shin Furukawa Takeshi Koshiya Hajime Sugawara Takumi Uchida Noe Takakubo Yasushi Ishigaki Susumu Suzuki Takashi Shimotomai Naoki Tamasawa Jun Matsui Takashi Goto Toshihide Oizumi Shinji Susa Makoto Daimon Hiroshi Murakami Takashi Sugawara Hiroaki Akai Mari Nakamura Yoshiji Ogawa Takao Yokoshima Tsuyoshi Watanabe Michio Shimabukuro Kazuhisa Tsukamoto Motoei Kunimi Jo Satoh Atushi Okuyama Kazutaka Ogawa Hideyuki Eguchi Mamoru Kimura Hiroshi Kouno Yohei Horikawa Shin Ikejima Masaru Saitoh Naoyoshi Minami Akihiro Sekikawa Toyoyoshi Uchida Toshihide Kawai Nobuya Fujita Ken Tomotsune Shigeo Yamashita Motoji Naka Toru Hiyoshi Tomotaka Katoh Kumiko Hamano Kouichi Inukai Takuma Kondo Kazuhiro Tsumura Yoko Matsuzawa Masahiro Mimura Masahiko Kawasumi Izumi Takei Masafumi Matsuda Ichiro Tatsuno Nobuyuki Banba Akihiko Ando Masao Toyoda Daisuke Suzuki Takahiro Iijima Yasumichi Mori Yutaka Uehara Yoshihiko Satoh Kazuaki Yahata Yoshimasa Asoh Koichiro Kuwabara Souichi Takizawa Yasushi Tanaka Koutaroh Yokote Masako Tohgo Takanobu Itoi Shigeru Miyazaki Hiroshi Itoh Teruo Shiba Takahisa Hirose Mariko Higa Masanobu Yamada Osamu Ogawa Masatoshi Kuroki Shinobu Satoh Makoto Ujihara Kenjiroh Yamanaka Hajime Koyano Tadashi Yamakawa Kenichiroh Takahashi Kazuki Orime Tsutomu Hirano Jiroh Morimoto Takashi Itoh Yuzoh Mizuno Naoyuki Yamamoto Han Miyatake Mina Yamaguchi Kenji Yamane Masahiko Kure Satoko Kawabe Masahumi Kakei Masashi Yoshida Hiroyuki Itoh Nobuaki Minami Kazuki Kobayashi Yusuke Fujino Makoto Shibuya Midori Hosokawa Isao Nozaki Chigure Nawa Tamio Ieiri Takayuki Watanabe Yoshio Katoh Takuyuki Katabami Michiko Handa Issei Shimada Kenichi Ohya Yoshihiro Ogawa Takanobu Yoshimoto Jiroh Nakamura Naotsuka Okayama Kenro Imaeda Syuko Yoshioka Masako Murakami Takashi Murase Yoshihiko Yamada Yutaka Yano Hiromitsu Sasaki Yasuhiro Sumida Osamu Yonaha Hiroshi Sobajima Mitsuyasu Ito Atushi Suzuki Atsuko Ishikawa Takehiko Ichikawa Shogo Asano Shinobu Goto Sakuma Hiroya Hiroshi Murase Shozo Ogawa Hideki Okamoto Kotaro Nagai Koji Nagayama Masanori Yoshida Norio Takahashi Kazuhisa Takami Tsuneo Ono Takanobu Morihiro Daisuke Tanaka Noriko Takahara Satoshi Miyata Mamiko Tsugawa Koichiro Yasuda Seiji Muro Masanori Emoto Ikuo Mineo Ichiro Shiojima Takeshi Kurose Makoto Ohashi Yumiko Kawabata Mitsushige Nishikawa Emiko Nomura Yasuyuki Nishimura Yasuhiro Ono Yasuhisa Yamamoto Keigo Naka Taizo Yamamoto Rika Usuda Hiroshi Akahori Seika Kato Hiroyuki Konya Yutaka Umayahara Takashi Seta Hideki Taki Masashi Sekiya Shinichi Mogami Sumie Fujii Toshiyuki Hibuse Shingo Tsuji Hirofumi Sumi Yasuro Kumeda Akinori Kogure Kenji Furukawa Akira Kuroe Hideaki Sawaki Narihiro Hibiki Yoshihiro Kitagawa Yukihiro Bando Akira Ono Rikako Uenaka Seitaro Omoto Yuki Kita Eiko Ri Ryutaro Numaguchi Sachiko Kawashima Ichiro Kisimoto Kiminori Hosoda Yoshihiko Araki Tetsuroh Arimura Mitsuru Hashiramoto Koumei Takeda Akira Matsutani Yasushi Inoue Fumio Sawano Nozomu Kamei Yasuo Ito Miwa Morita Yoshiaki Oda Rui Kishimoto Katsuhiro Hatao Tomoatsu Mune Fumiko Kawasaki Hiroki Teragawa Ken Yaga Keita Ishii Kyouji Hirata Tatsuaki Nakatou Yutaka Nitta Naoki Fujita Masayasu Yoneda Masatoshi Tsuru Shinichirou Ando Toshiaki Kakiba Michihiro Toyoshige Tsuguka Shiwa Hiroaki Miyaoka Yasumi Shintani Takenori Sakai Tetsuji Niiya Shinpei Fujimoto Hisaka Minami Yoshihiko Noma Masaaki Tamaru Yoshitaka Sayou Tomoyo Oyama Masamoto Torisu Yuichi Fujinaka Yoshitaka Kumon Shozo Miyauchi Morikazu Onji Toru Nakamura Yousuke Okada Toshihiko Yanase Kenro Nishida Syuji Nakamura Kunihisa Kobayashi Nobuhiko Wada Moritake Higa Koji Matsushita Yoshihiko Nishio Ryoji Fujimoto Yasuyuki Kihara Shinichiro Mine Tadashi Arao Hiromi Tasaki Yasuto Matsuo Hirofumi Matsuda Kohei Uriu Kazuko Kanda Kazuo Ibaraki Yoshio Kaku Yasuhiro Takaki Iwaho Hazekawa Kenji Ebihara Eiichiro Watanabe Iku Sakurada Kazuhisa Muraishi Tamami Oshige Junichi Yasuda Toyoshi Iguchi Noriyuki Sonoda Masahiro Adachi Isao Ichino Yuko Horiuchi Souichi Uekihara Shingo Morimitsu Mitsuhiro Nakazawa Tadashi Seguchi Kengo Kaneko
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author-letter	Masakazu Kobayashi
doi_str_mv	10.1136/bmjdrc-2020-001787
author2-role	verfasserin
title_sort	long-term safety and efficacy of alogliptin, a dpp-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (j-brand registry)
callnumber	RC648-665
title_auth	Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry)
abstract	Introduction Given an increasing use of dipeptidyl peptidase-4 (DPP-4) inhibitors to treat patients with type 2 diabetes mellitus in the real-world setting, we conducted a prospective observational study (Japan-based Clinical Research Network for Diabetes Registry: J-BRAND Registry) to elucidate the safety and efficacy profile of long-term usage of alogliptin.Research design and methods We registered 5969 patients from April 2012 through September 2014, who started receiving alogliptin (group A) or other classes of oral hypoglycemic agents (OHAs; group B), and were followed for 3 years at 239 sites nationwide. Safety was the primary outcome. Symptomatic hypoglycemia, pancreatitis, skin disorders of non-extrinsic origin, severe infections, and cancer were collected as major adverse events (AEs). Efficacy assessment was the secondary outcome and included changes in hemoglobin A1c (HbA1c), fasting blood glucose, fasting insulin and urinary albumin.Results Of the registered, 5150 (group A: 3395 and group B: 1755) and 5096 (3358 and 1738) were included for safety and efficacy analysis, respectively. Group A patients mostly (>90%) continued to use alogliptin. In group B, biguanides were the primary agents, while DPP-4 inhibitors were added in up to ~36% of patients. The overall incidence of AEs was similar between the two groups (42.7% vs 42.2%). Kaplan-Meier analysis revealed the incidence of cancer was significantly higher in group A than in group B (7.4% vs 4.8%, p=0.040), while no significant incidence difference was observed in the individual cancer. Multivariate Cox regression analysis revealed that the imbalanced patient distribution (more elderly patients in group A than in group B), but not alogliptin usage per se, contributed to cancer development. The incidence of other major AE categories was with no between-group difference. Between-group difference was not detected, either, in the incidence of microvascular and macrovascular complications. HbA1c and fasting glucose decreased significantly at the 0.5-year visit and nearly plateaued thereafter in both groups.Conclusions Alogliptin as a representative of DPP-4 inhibitors was safe and durably efficacious when used alone or with other OHAs for patients with type 2 diabetes in the real world setting.
abstractGer	Introduction Given an increasing use of dipeptidyl peptidase-4 (DPP-4) inhibitors to treat patients with type 2 diabetes mellitus in the real-world setting, we conducted a prospective observational study (Japan-based Clinical Research Network for Diabetes Registry: J-BRAND Registry) to elucidate the safety and efficacy profile of long-term usage of alogliptin.Research design and methods We registered 5969 patients from April 2012 through September 2014, who started receiving alogliptin (group A) or other classes of oral hypoglycemic agents (OHAs; group B), and were followed for 3 years at 239 sites nationwide. Safety was the primary outcome. Symptomatic hypoglycemia, pancreatitis, skin disorders of non-extrinsic origin, severe infections, and cancer were collected as major adverse events (AEs). Efficacy assessment was the secondary outcome and included changes in hemoglobin A1c (HbA1c), fasting blood glucose, fasting insulin and urinary albumin.Results Of the registered, 5150 (group A: 3395 and group B: 1755) and 5096 (3358 and 1738) were included for safety and efficacy analysis, respectively. Group A patients mostly (>90%) continued to use alogliptin. In group B, biguanides were the primary agents, while DPP-4 inhibitors were added in up to ~36% of patients. The overall incidence of AEs was similar between the two groups (42.7% vs 42.2%). Kaplan-Meier analysis revealed the incidence of cancer was significantly higher in group A than in group B (7.4% vs 4.8%, p=0.040), while no significant incidence difference was observed in the individual cancer. Multivariate Cox regression analysis revealed that the imbalanced patient distribution (more elderly patients in group A than in group B), but not alogliptin usage per se, contributed to cancer development. The incidence of other major AE categories was with no between-group difference. Between-group difference was not detected, either, in the incidence of microvascular and macrovascular complications. HbA1c and fasting glucose decreased significantly at the 0.5-year visit and nearly plateaued thereafter in both groups.Conclusions Alogliptin as a representative of DPP-4 inhibitors was safe and durably efficacious when used alone or with other OHAs for patients with type 2 diabetes in the real world setting.
abstract_unstemmed	Introduction Given an increasing use of dipeptidyl peptidase-4 (DPP-4) inhibitors to treat patients with type 2 diabetes mellitus in the real-world setting, we conducted a prospective observational study (Japan-based Clinical Research Network for Diabetes Registry: J-BRAND Registry) to elucidate the safety and efficacy profile of long-term usage of alogliptin.Research design and methods We registered 5969 patients from April 2012 through September 2014, who started receiving alogliptin (group A) or other classes of oral hypoglycemic agents (OHAs; group B), and were followed for 3 years at 239 sites nationwide. Safety was the primary outcome. Symptomatic hypoglycemia, pancreatitis, skin disorders of non-extrinsic origin, severe infections, and cancer were collected as major adverse events (AEs). Efficacy assessment was the secondary outcome and included changes in hemoglobin A1c (HbA1c), fasting blood glucose, fasting insulin and urinary albumin.Results Of the registered, 5150 (group A: 3395 and group B: 1755) and 5096 (3358 and 1738) were included for safety and efficacy analysis, respectively. Group A patients mostly (>90%) continued to use alogliptin. In group B, biguanides were the primary agents, while DPP-4 inhibitors were added in up to ~36% of patients. The overall incidence of AEs was similar between the two groups (42.7% vs 42.2%). Kaplan-Meier analysis revealed the incidence of cancer was significantly higher in group A than in group B (7.4% vs 4.8%, p=0.040), while no significant incidence difference was observed in the individual cancer. Multivariate Cox regression analysis revealed that the imbalanced patient distribution (more elderly patients in group A than in group B), but not alogliptin usage per se, contributed to cancer development. The incidence of other major AE categories was with no between-group difference. Between-group difference was not detected, either, in the incidence of microvascular and macrovascular complications. HbA1c and fasting glucose decreased significantly at the 0.5-year visit and nearly plateaued thereafter in both groups.Conclusions Alogliptin as a representative of DPP-4 inhibitors was safe and durably efficacious when used alone or with other OHAs for patients with type 2 diabetes in the real world setting.
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title_short	Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry)
url	https://doi.org/10.1136/bmjdrc-2020-001787 https://doaj.org/article/9dc90dc2c997472e81cb2c1c6cd779d5 https://drc.bmj.com/content/9/1/e001787.full https://doaj.org/toc/2052-4897
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author2	Hirohito Sone Haruhiko Osawa Daisuke Koya Takanori Miura Yoshihito Atsumi Udai Nakamura Eiichi Araki Hitoshi Shimano Yukio Tanizawa Jiro Nakamura Yuichiro Yamada Nobuya Inagaki Atsuko Abiko Hideki Katagiri Michio Hayashi Keiko Naruse Shimpei Fujimoto Masazumi Fujiwara Kenichi Shikata Yosuke Okada Tsutomu Yamazaki Sou Nagai Katsuyuki Yanagisawa Hiromichi Kijima Shinji Taneda Shigeyuki Saitoh Daisuke Ikeda Fuminori Hirano Haruhiko Yoshimura Mitsutaka Inoue Masahiko Katoh Osamu Nakagaki Chiho Yamamoto Akitsuki Morikawa Shin Furukawa Takeshi Koshiya Hajime Sugawara Takumi Uchida Noe Takakubo Yasushi Ishigaki Susumu Suzuki Takashi Shimotomai Naoki Tamasawa Jun Matsui Takashi Goto Toshihide Oizumi Shinji Susa Makoto Daimon Hiroshi Murakami Takashi Sugawara Hiroaki Akai Mari Nakamura Yoshiji Ogawa Takao Yokoshima Tsuyoshi Watanabe Michio Shimabukuro Kazuhisa Tsukamoto Motoei Kunimi Jo Satoh Atushi Okuyama Kazutaka Ogawa Hideyuki Eguchi Mamoru Kimura Hiroshi Kouno Yohei Horikawa Shin Ikejima Masaru Saitoh Naoyoshi Minami Akihiro Sekikawa Toyoyoshi Uchida Toshihide Kawai Nobuya Fujita Ken Tomotsune Shigeo Yamashita Motoji Naka Toru Hiyoshi Tomotaka Katoh Kumiko Hamano Kouichi Inukai Takuma Kondo Kazuhiro Tsumura Yoko Matsuzawa Masahiro Mimura Masahiko Kawasumi Izumi Takei Masafumi Matsuda Ichiro Tatsuno Nobuyuki Banba Akihiko Ando Masao Toyoda Daisuke Suzuki Takahiro Iijima Yasumichi Mori Yutaka Uehara Yoshihiko Satoh Kazuaki Yahata Yoshimasa Asoh Koichiro Kuwabara Souichi Takizawa Yasushi Tanaka Koutaroh Yokote Masako Tohgo Takanobu Itoi Shigeru Miyazaki Hiroshi Itoh Teruo Shiba Takahisa Hirose Mariko Higa Masanobu Yamada Osamu Ogawa Masatoshi Kuroki Shinobu Satoh Makoto Ujihara Kenjiroh Yamanaka Hajime Koyano Tadashi Yamakawa Kenichiroh Takahashi Kazuki Orime Tsutomu Hirano Jiroh Morimoto Takashi Itoh Yuzoh Mizuno Naoyuki Yamamoto Han Miyatake Mina Yamaguchi Kenji Yamane Masahiko Kure Satoko Kawabe Masahumi Kakei Masashi Yoshida Hiroyuki Itoh Nobuaki Minami Kazuki Kobayashi Yusuke Fujino Makoto Shibuya Midori Hosokawa Isao Nozaki Chigure Nawa Tamio Ieiri Takayuki Watanabe Yoshio Katoh Takuyuki Katabami Michiko Handa Issei Shimada Kenichi Ohya Yoshihiro Ogawa Takanobu Yoshimoto Jiroh Nakamura Naotsuka Okayama Kenro Imaeda Syuko Yoshioka Masako Murakami Takashi Murase Yoshihiko Yamada Yutaka Yano Hiromitsu Sasaki Yasuhiro Sumida Osamu Yonaha Hiroshi Sobajima Mitsuyasu Ito Atushi Suzuki Atsuko Ishikawa Takehiko Ichikawa Shogo Asano Shinobu Goto Sakuma Hiroya Hiroshi Murase Shozo Ogawa Hideki Okamoto Kotaro Nagai Koji Nagayama Masanori Yoshida Norio Takahashi Kazuhisa Takami Tsuneo Ono Takanobu Morihiro Daisuke Tanaka Noriko Takahara Satoshi Miyata Mamiko Tsugawa Koichiro Yasuda Seiji Muro Masanori Emoto Ikuo Mineo Ichiro Shiojima Takeshi Kurose Makoto Ohashi Yumiko Kawabata Mitsushige Nishikawa Emiko Nomura Yasuyuki Nishimura Yasuhiro Ono Yasuhisa Yamamoto Keigo Naka Taizo Yamamoto Rika Usuda Hiroshi Akahori Seika Kato Hiroyuki Konya Yutaka Umayahara Takashi Seta Hideki Taki Masashi Sekiya Shinichi Mogami Sumie Fujii Toshiyuki Hibuse Shingo Tsuji Hirofumi Sumi Yasuro Kumeda Akinori Kogure Kenji Furukawa Akira Kuroe Hideaki Sawaki Narihiro Hibiki Yoshihiro Kitagawa Yukihiro Bando Akira Ono Rikako Uenaka Seitaro Omoto Yuki Kita Eiko Ri Ryutaro Numaguchi Sachiko Kawashima Ichiro Kisimoto Kiminori Hosoda Yoshihiko Araki Tetsuroh Arimura Mitsuru Hashiramoto Koumei Takeda Akira Matsutani Yasushi Inoue Fumio Sawano Nozomu Kamei Yasuo Ito Miwa Morita Yoshiaki Oda Rui Kishimoto Katsuhiro Hatao Tomoatsu Mune Fumiko Kawasaki Hiroki Teragawa Ken Yaga Keita Ishii Kyouji Hirata Tatsuaki Nakatou Yutaka Nitta Naoki Fujita Masayasu Yoneda Masatoshi Tsuru Shinichirou Ando Toshiaki Kakiba Michihiro Toyoshige Tsuguka Shiwa Hiroaki Miyaoka Yasumi Shintani Takenori Sakai Tetsuji Niiya Shinpei Fujimoto Hisaka Minami Yoshihiko Noma Masaaki Tamaru Yoshitaka Sayou Tomoyo Oyama Masamoto Torisu Yuichi Fujinaka Yoshitaka Kumon Shozo Miyauchi Morikazu Onji Toru Nakamura Yousuke Okada Toshihiko Yanase Kenro Nishida Syuji Nakamura Kunihisa Kobayashi Nobuhiko Wada Moritake Higa Koji Matsushita Yoshihiko Nishio Ryoji Fujimoto Yasuyuki Kihara Shinichiro Mine Tadashi Arao Hiromi Tasaki Yasuto Matsuo Hirofumi Matsuda Kohei Uriu Kazuko Kanda Kazuo Ibaraki Yoshio Kaku Yasuhiro Takaki Iwaho Hazekawa Kenji Ebihara Eiichiro Watanabe Iku Sakurada Kazuhisa Muraishi Tamami Oshige Junichi Yasuda Toyoshi Iguchi Noriyuki Sonoda Masahiro Adachi Isao Ichino Yuko Horiuchi Souichi Uekihara Shingo Morimitsu Mitsuhiro Nakazawa Tadashi Seguchi Kengo Kaneko
author2Str	Hirohito Sone Haruhiko Osawa Daisuke Koya Takanori Miura Yoshihito Atsumi Udai Nakamura Eiichi Araki Hitoshi Shimano Yukio Tanizawa Jiro Nakamura Yuichiro Yamada Nobuya Inagaki Atsuko Abiko Hideki Katagiri Michio Hayashi Keiko Naruse Shimpei Fujimoto Masazumi Fujiwara Kenichi Shikata Yosuke Okada Tsutomu Yamazaki Sou Nagai Katsuyuki Yanagisawa Hiromichi Kijima Shinji Taneda Shigeyuki Saitoh Daisuke Ikeda Fuminori Hirano Haruhiko Yoshimura Mitsutaka Inoue Masahiko Katoh Osamu Nakagaki Chiho Yamamoto Akitsuki Morikawa Shin Furukawa Takeshi Koshiya Hajime Sugawara Takumi Uchida Noe Takakubo Yasushi Ishigaki Susumu Suzuki Takashi Shimotomai Naoki Tamasawa Jun Matsui Takashi Goto Toshihide Oizumi Shinji Susa Makoto Daimon Hiroshi Murakami Takashi Sugawara Hiroaki Akai Mari Nakamura Yoshiji Ogawa Takao Yokoshima Tsuyoshi Watanabe Michio Shimabukuro Kazuhisa Tsukamoto Motoei Kunimi Jo Satoh Atushi Okuyama Kazutaka Ogawa Hideyuki Eguchi Mamoru Kimura Hiroshi Kouno Yohei Horikawa Shin Ikejima Masaru Saitoh Naoyoshi Minami Akihiro Sekikawa Toyoyoshi Uchida Toshihide Kawai Nobuya Fujita Ken Tomotsune Shigeo Yamashita Motoji Naka Toru Hiyoshi Tomotaka Katoh Kumiko Hamano Kouichi Inukai Takuma Kondo Kazuhiro Tsumura Yoko Matsuzawa Masahiro Mimura Masahiko Kawasumi Izumi Takei Masafumi Matsuda Ichiro Tatsuno Nobuyuki Banba Akihiko Ando Masao Toyoda Daisuke Suzuki Takahiro Iijima Yasumichi Mori Yutaka Uehara Yoshihiko Satoh Kazuaki Yahata Yoshimasa Asoh Koichiro Kuwabara Souichi Takizawa Yasushi Tanaka Koutaroh Yokote Masako Tohgo Takanobu Itoi Shigeru Miyazaki Hiroshi Itoh Teruo Shiba Takahisa Hirose Mariko Higa Masanobu Yamada Osamu Ogawa Masatoshi Kuroki Shinobu Satoh Makoto Ujihara Kenjiroh Yamanaka Hajime Koyano Tadashi Yamakawa Kenichiroh Takahashi Kazuki Orime Tsutomu Hirano Jiroh Morimoto Takashi Itoh Yuzoh Mizuno Naoyuki Yamamoto Han Miyatake Mina Yamaguchi Kenji Yamane Masahiko Kure Satoko Kawabe Masahumi Kakei Masashi Yoshida Hiroyuki Itoh Nobuaki Minami Kazuki Kobayashi Yusuke Fujino Makoto Shibuya Midori Hosokawa Isao Nozaki Chigure Nawa Tamio Ieiri Takayuki Watanabe Yoshio Katoh Takuyuki Katabami Michiko Handa Issei Shimada Kenichi Ohya Yoshihiro Ogawa Takanobu Yoshimoto Jiroh Nakamura Naotsuka Okayama Kenro Imaeda Syuko Yoshioka Masako Murakami Takashi Murase Yoshihiko Yamada Yutaka Yano Hiromitsu Sasaki Yasuhiro Sumida Osamu Yonaha Hiroshi Sobajima Mitsuyasu Ito Atushi Suzuki Atsuko Ishikawa Takehiko Ichikawa Shogo Asano Shinobu Goto Sakuma Hiroya Hiroshi Murase Shozo Ogawa Hideki Okamoto Kotaro Nagai Koji Nagayama Masanori Yoshida Norio Takahashi Kazuhisa Takami Tsuneo Ono Takanobu Morihiro Daisuke Tanaka Noriko Takahara Satoshi Miyata Mamiko Tsugawa Koichiro Yasuda Seiji Muro Masanori Emoto Ikuo Mineo Ichiro Shiojima Takeshi Kurose Makoto Ohashi Yumiko Kawabata Mitsushige Nishikawa Emiko Nomura Yasuyuki Nishimura Yasuhiro Ono Yasuhisa Yamamoto Keigo Naka Taizo Yamamoto Rika Usuda Hiroshi Akahori Seika Kato Hiroyuki Konya Yutaka Umayahara Takashi Seta Hideki Taki Masashi Sekiya Shinichi Mogami Sumie Fujii Toshiyuki Hibuse Shingo Tsuji Hirofumi Sumi Yasuro Kumeda Akinori Kogure Kenji Furukawa Akira Kuroe Hideaki Sawaki Narihiro Hibiki Yoshihiro Kitagawa Yukihiro Bando Akira Ono Rikako Uenaka Seitaro Omoto Yuki Kita Eiko Ri Ryutaro Numaguchi Sachiko Kawashima Ichiro Kisimoto Kiminori Hosoda Yoshihiko Araki Tetsuroh Arimura Mitsuru Hashiramoto Koumei Takeda Akira Matsutani Yasushi Inoue Fumio Sawano Nozomu Kamei Yasuo Ito Miwa Morita Yoshiaki Oda Rui Kishimoto Katsuhiro Hatao Tomoatsu Mune Fumiko Kawasaki Hiroki Teragawa Ken Yaga Keita Ishii Kyouji Hirata Tatsuaki Nakatou Yutaka Nitta Naoki Fujita Masayasu Yoneda Masatoshi Tsuru Shinichirou Ando Toshiaki Kakiba Michihiro Toyoshige Tsuguka Shiwa Hiroaki Miyaoka Yasumi Shintani Takenori Sakai Tetsuji Niiya Shinpei Fujimoto Hisaka Minami Yoshihiko Noma Masaaki Tamaru Yoshitaka Sayou Tomoyo Oyama Masamoto Torisu Yuichi Fujinaka Yoshitaka Kumon Shozo Miyauchi Morikazu Onji Toru Nakamura Yousuke Okada Toshihiko Yanase Kenro Nishida Syuji Nakamura Kunihisa Kobayashi Nobuhiko Wada Moritake Higa Koji Matsushita Yoshihiko Nishio Ryoji Fujimoto Yasuyuki Kihara Shinichiro Mine Tadashi Arao Hiromi Tasaki Yasuto Matsuo Hirofumi Matsuda Kohei Uriu Kazuko Kanda Kazuo Ibaraki Yoshio Kaku Yasuhiro Takaki Iwaho Hazekawa Kenji Ebihara Eiichiro Watanabe Iku Sakurada Kazuhisa Muraishi Tamami Oshige Junichi Yasuda Toyoshi Iguchi Noriyuki Sonoda Masahiro Adachi Isao Ichino Yuko Horiuchi Souichi Uekihara Shingo Morimitsu Mitsuhiro Nakazawa Tadashi Seguchi Kengo Kaneko
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doi_str	10.1136/bmjdrc-2020-001787
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up_date	2024-07-03T23:43:40.474Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ002062054</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309165407.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1136/bmjdrc-2020-001787</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ002062054</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ9dc90dc2c997472e81cb2c1c6cd779d5</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC648-665</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Masakazu Kobayashi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction Given an increasing use of dipeptidyl peptidase-4 (DPP-4) inhibitors to treat patients with type 2 diabetes mellitus in the real-world setting, we conducted a prospective observational study (Japan-based Clinical Research Network for Diabetes Registry: J-BRAND Registry) to elucidate the safety and efficacy profile of long-term usage of alogliptin.Research design and methods We registered 5969 patients from April 2012 through September 2014, who started receiving alogliptin (group A) or other classes of oral hypoglycemic agents (OHAs; group B), and were followed for 3 years at 239 sites nationwide. Safety was the primary outcome. Symptomatic hypoglycemia, pancreatitis, skin disorders of non-extrinsic origin, severe infections, and cancer were collected as major adverse events (AEs). Efficacy assessment was the secondary outcome and included changes in hemoglobin A1c (HbA1c), fasting blood glucose, fasting insulin and urinary albumin.Results Of the registered, 5150 (group A: 3395 and group B: 1755) and 5096 (3358 and 1738) were included for safety and efficacy analysis, respectively. Group A patients mostly (&gt;90%) continued to use alogliptin. In group B, biguanides were the primary agents, while DPP-4 inhibitors were added in up to ~36% of patients. The overall incidence of AEs was similar between the two groups (42.7% vs 42.2%). Kaplan-Meier analysis revealed the incidence of cancer was significantly higher in group A than in group B (7.4% vs 4.8%, p=0.040), while no significant incidence difference was observed in the individual cancer. Multivariate Cox regression analysis revealed that the imbalanced patient distribution (more elderly patients in group A than in group B), but not alogliptin usage per se, contributed to cancer development. The incidence of other major AE categories was with no between-group difference. Between-group difference was not detected, either, in the incidence of microvascular and macrovascular complications. HbA1c and fasting glucose decreased significantly at the 0.5-year visit and nearly plateaued thereafter in both groups.Conclusions Alogliptin as a representative of DPP-4 inhibitors was safe and durably efficacious when used alone or with other OHAs for patients with type 2 diabetes in the real world setting.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the endocrine glands. Clinical endocrinology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hirohito Sone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Haruhiko Osawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daisuke Koya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takanori Miura</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yoshihito Atsumi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Udai Nakamura</subfield><subfield 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Inagaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Atsuko Abiko</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hideki Katagiri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michio Hayashi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Keiko Naruse</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shimpei Fujimoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masazumi Fujiwara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenichi Shikata</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yosuke Okada</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tsutomu Yamazaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sou Nagai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katsuyuki Yanagisawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiromichi Kijima</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shinji Taneda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shigeyuki Saitoh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daisuke Ikeda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fuminori Hirano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Haruhiko Yoshimura</subfield><subfield code="e">verfasserin</subfield><subfield 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Suzuki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takashi Shimotomai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Naoki Tamasawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jun Matsui</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takashi Goto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Toshihide Oizumi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield 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code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yasushi Tanaka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Koutaroh Yokote</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masako Tohgo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takanobu Itoi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shigeru Miyazaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiroshi Itoh</subfield><subfield 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Kuroki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shinobu Satoh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Makoto Ujihara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenjiroh Yamanaka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hajime Koyano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tadashi Yamakawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenichiroh Takahashi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kazuki Orime</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tsutomu Hirano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jiroh Morimoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takashi Itoh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yuzoh Mizuno</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Naoyuki Yamamoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Han Miyatake</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mina Yamaguchi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenji Yamane</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masahiko Kure</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Satoko Kawabe</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masahumi Kakei</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masashi Yoshida</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiroyuki Itoh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nobuaki Minami</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kazuki Kobayashi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yusuke Fujino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Makoto Shibuya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Midori Hosokawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Isao Nozaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chigure Nawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tamio Ieiri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takayuki Watanabe</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yoshio Katoh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takuyuki Katabami</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michiko Handa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Issei Shimada</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenichi Ohya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yoshihiro Ogawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takanobu Yoshimoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jiroh Nakamura</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Naotsuka Okayama</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenro Imaeda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Syuko Yoshioka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masako Murakami</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takashi Murase</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yoshihiko Yamada</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yutaka Yano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiromitsu Sasaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yasuhiro Sumida</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Osamu Yonaha</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiroshi Sobajima</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mitsuyasu Ito</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Atushi Suzuki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Atsuko Ishikawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takehiko Ichikawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shogo Asano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shinobu Goto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sakuma Hiroya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiroshi Murase</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shozo Ogawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hideki Okamoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kotaro Nagai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Koji Nagayama</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masanori Yoshida</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Norio Takahashi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kazuhisa Takami</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tsuneo Ono</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takanobu Morihiro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daisuke Tanaka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Noriko Takahara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Satoshi Miyata</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mamiko Tsugawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Koichiro Yasuda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Seiji Muro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masanori Emoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ikuo Mineo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ichiro Shiojima</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takeshi Kurose</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Makoto Ohashi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yumiko Kawabata</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mitsushige Nishikawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emiko Nomura</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yasuyuki Nishimura</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yasuhiro Ono</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yasuhisa Yamamoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Keigo Naka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Taizo Yamamoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rika Usuda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiroshi Akahori</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Seika Kato</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hiroyuki Konya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yutaka Umayahara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Takashi Seta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hideki Taki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masashi Sekiya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shinichi Mogami</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sumie Fujii</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Toshiyuki Hibuse</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shingo Tsuji</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hirofumi Sumi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yasuro Kumeda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Akinori Kogure</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenji Furukawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Akira Kuroe</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hideaki Sawaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Narihiro Hibiki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yoshihiro Kitagawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yukihiro Bando</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Akira Ono</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rikako Uenaka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Seitaro Omoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yuki Kita</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eiko Ri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ryutaro 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Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry)

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